Personnel

Dr Brian D Green

• Position: Senior Lecturer in Molecular Nutrition
• Contact details: Queen’s University Belfast
• Email: b.green@qub.ac.uk
• Telephone: 44-2890-97-6541

Research Interests

My interests are in the development and application of metabolomics platforms for the study of human metabolic and neurodegenerative diseases. The rapidly emerging field of metabolomics establishes disease specific signatures describing perturbations in hundreds of metabolites and it reflects how biochemical pathways and networks are affected. I am particularly interested in identifying and elucidating biochemical pathways that are disrupted in Alzheimer’s disease (AD), and in furthering the use of this technology for AD diagnostics.

Publications

Graham SF, Chevallier OP, Roberts D, Hölscher C, Elliott CT, Green BD. Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease. Anal Chem. 2013 Feb 5;85(3):1803-11.

Graham SF, Hölscher C, McClean PL, Elliott CT, Green BD. 1H NMR metabolomics investigation of an Alzheimer’s disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma. Metabolomics. 2013, Oct

Graham SF, Holscher C, Green BD. Metabolic signatures of human Alzheimer’s disease (AD): 1H NMR analysis of the polar metabolome of post-mortem brain tissue. Metabolomics 2013 (In press).

Research Funding

Alzheimer’s Research UK, Pilot Grant, Development of novel “omics” approaches for early detection investigation of human Alzheimer’s disease.

Alzheimer’s Research UK, Network Cooperation Grant, A multi-centre study using a validated high resolution metabolomics methodology to investigate Alzheimer's disease (AD).

Alzheimer’s Research UK, Network Centre, Northern Ireland

Invest Northern Ireland, Proof of Concept, Development of a metabolomics blood test for the pre-symptomatic diagnosis of Alzheimer’s disease.

Relevant Links

https://www.researchgate.net/profile/Brian_Green5/ 
http://www.qub.ac.uk/alzheimers
http://www.alzheimersresearchuk.org