Dr. Anne Molloy
Fellow Emeritus, Clinical Medicine
Fellow Emeritus, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
O'Connor DMA, Laird EJ, Carey D, O'Halloran AM, Clarke R, Kenny RA, Molloy AM., Plasma concentrations of vitamin B12 and folate and global cognitive function in an older population: Cross-sectional findings from The Irish Longitudinal Study on Ageing (TILDA)., The British journal of nutrition, 2020, p1-25
Stevelink R, Pangilinan F, Jansen FE, Braun KPJ, International League Against Epilepsy Consortium on Complex Epilepsies, Molloy AM, Brody LC, Koeleman BPC., Assessing the genetic association between vitamin B6 metabolism and genetic generalized epilepsy., Molecular genetics and metabolism reports, 21, 2019, p100518
O'Halloran AM, Laird EJ, Feeney J, Healy M, Moran R, Beatty S, Nolan FM, Molloy AM, Kenny RA. , Circulating micronutrient biomarkers are associated with three measures of frailty: Evidence from The Irish Longitudinal Study on Ageing (TILDA). , JAMDA, 2019
Laird EJ, McNicholas T, O'Halloran AM, Healy M, Molloy AM, Carey D, O'Connor D, McCarroll K, Kenny RA., Vitamin D Status Is Not Associated With Orthostatic Hypotension in Older Adults., Hypertension (Dallas, Tex. : 1979), 74, (3), 2019, p639-644
McNulty H, Rollins M, Cassidy T, Caffrey A, Marshall B, Dornan J, McLaughlin M, McNulty BA, Ward M, Strain JJ, Molloy AM, Lees-Murdock DJ, Walsh CP, Pentieva K., Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)., BMC medicine, 17, (1), 2019, p196
Porter KM, Ward M, Hughes CF, O'Kane M, Hoey L, McCann A, Molloy AM, Cunningham C, Casey MC, Tracey F, Strain S, McCarroll K, Laird E, Gallagher AM, McNulty H., Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults., The Journal of clinical endocrinology and metabolism, 104, (10), 2019, p4837-4847
Cawley S, O'Malley EG, Kennedy RAK, Reynolds CME, Molloy AM, Turner MJ., The relationship between maternal plasma homocysteine in early pregnancy and birth weight., J Matern Fetal Neonatal Med, 2019, p1-5
Moore K, Hughes CF, Hoey L, Ward M, Cunningham C, Molloy AM, Strain JJ, McCarroll K, Casey MC, Tracey F, Laird E, O'Kane M, McNulty H., B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study., Journal of the American Medical Directors Association, 2019, p551-557.e1
Brosnan, J.T. and Mills, J.L. and Ueland, P.M. and Shane, B. and Fan, R. and Chiu, C.-Y. and Pangilinan, F. and Brody, L.C. and Brosnan, M.E. and Pongnopparat, T. and Molloy, A.M., Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults, American Journal of Clinical Nutrition, 107, (3), 2018, p345-354
Laird, E. and O'Halloran, A.M. and Carey, D. and Healy, M. and O'Connor, D. and Moore, P. and Shannon, T. and Molloy, A.M. and Kenny, R.A., The Prevalence of Vitamin D Deficiency and the Determinants of 25(OH)D Concentration in Older Irish Adults: Data from the Irish Longitudinal Study on Ageing (TILDA), Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73, (4), 2018, p519-525
Höller, U. and Bakker, S.J.L. and DÌsterloh, A. and Frei, B. and Köhrle, J. and Konz, T. and Lietz, G. and McCann, A. and Michels, A.J. and Molloy, A.M. and Murakami, H. and Rein, D. and Saris, W.H.M. and Schmidt, K. and Shimbo, K. and Schumacher, S. and Vermeer, C. and Kaput, J. and Weber, P. and Eggersdorfer, M. and Rezzi, S., Micronutrient status assessment in humans: Current methods of analysis and future trends, TrAC - Trends in Analytical Chemistry, 102, 2018, p110-122
Ntlholang O, McCarroll K, Laird E, Molloy AM, Ward M, McNulty H, Hoey L, Hughes CF, Strain JJ, Casey M, Cunningham C, The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study., The British journal of nutrition, 2018
O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM., The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites., Molecular genetics and metabolism reports, 16, 2018, p20-22
Shane B, Pangilinan F, Mills JL, Fan R, Gong T, Cropp CD, Kim Y, Ueland PM, Bailey-Wilson JE, Wilson AF, Brody LC, Molloy AM., The 677C"T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population., The American journal of clinical nutrition, 108, (6), 2018, p1334-1341
Laird EJ, O'Halloran AM, Carey D, O'Connor D, Kenny RA, Molloy AM, Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA)., The British journal of nutrition, 2018, p111 - 120
Molloy AM, Mills JL., Fortifying food with folic acid to prevent neural tube defects: are we now where we ought to be?, The American journal of clinical nutrition, 107, (6), 2018, p857-858
Molloy AM., Should vitamin B12 status be considered in assessing risk of neural tube defects?, Annals of the New York Academy of Sciences, 2018, p109-125
Bernard DJ, Pangilinan FJ, Cheng J, Molloy AM, Brody LC., Mice lacking the transcobalamin-vitamin B12 receptor, CD320, suffer from anemia and reproductive deficits when fed vitamin B12-deficient diet., Human molecular genetics, 27, (20), 2018, p3627-3640
International League Against Epilepsy Consortium on Complex Epilepsies., Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies., Nature communications, 9, (1), 2018, p5269
Mills JL, Molloy AM, Reynolds EH., Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12 deficiency?, BMJ (Clinical research ed.), 360, 2018, pk724
McCann A, McNulty H, Rigby J, Hughes CF, Hoey L, Molloy AM, Cunningham CJ, Casey MC, Tracey F, O'Kane MJ, McCarroll K, Ward M, Moore K, Strain JJ, Moore A., Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults., Journal of the American Geriatrics Society, 2018, p1 - 7
O'Malley EG, Cawley S, Kennedy RAK, Reynolds CME, Molloy A, Turner MJ., Maternal anaemia and folate intake in early pregnancy., Journal of public health (Oxford, England), 2018, pdy013-
Molloy AM, Pangilinan F, Brody LC., Genetic Risk Factors for Folate-Responsive Neural Tube Defects., Annual review of nutrition, 37, 2017, p269-291
Cawley S, McCartney D, Woodside JV, Sweeney MR, McDonnell R, Molloy AM, Turner MJ., Optimization of folic acid supplementation in the prevention of neural tube defects., Journal of public health (Oxford, England), 2017, p1-8
Green R, Allen L.H, BjÃ"rke-Monsen A.-L, Brito A, Guéant J.-L, Miller J.W, Molloy A.M, Nexo E, Stabler S, Toh B.-H, Ueland P.M, Yajnik C, Vitamin B
Murphy M.M, Fernandez-Ballart J.D, Molloy A.M, Canals J, Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4months and 6years after birth., Maternal & Child Nutrition, 13, (12), 2017, pe12289-
Laird E, O'Halloran AM, Carey D, Healy M, O'Connor D, Moore P, Shannon T, Molloy AM, Kenny RA., The prevalence of vitamin D deficiency and the determinants of 25(OH)D concentration in older Irish adults: Data from The Irish Longitudinal Study on Ageing (TILDA)., The journals of gerontology. Series A, Biological sciences and medical sciences, 2017
Mossey, P.A. and Little, J. and Steegers-Theunissen, R. and Molloy, A. and Peterlin, B. and Shaw, W.C. and Johnson, C. and FitzPatrickd, D.R. and Franceschelli, P. and Rubini, M., Genetic interactions in nonsyndromic orofacial clefts in Europe-EUROCRAN Study, Cleft Palate-Craniofacial Journal, 54, (6), 2017, p623-630
Velkova A, Diaz JEL, Pangilinan F, Molloy AM, Mills JL, Shane B, Sanchez E, Cunningham C, McNulty H, Cropp CD, Bailey-Wilson JE, Wilson AF, Brody LC., The FUT2 secretor variant p.Trp154Ter influences serum vitamin B12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation., Human molecular genetics, 26, (24), 2017, p4975-4988
Hughes C.F, Ward M, Tracey F, Hoey L, Molloy A.M, Pentieva K, McNulty H, B-vitamin intake and biomarker status in relation to cognitive decline in healthy older adults in a 4-year follow-up study, Nutrients, 9, (1), 2017, p53-
Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GL., The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland., Scientific reports, 7, (1), 2017, p17199
Laird E, Molloy A.M, McNulty H, Ward M, McCarroll K, Hoey L, Hughes C.F, Cunningham C, Strain J.J, Casey M.C, Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults, Osteoporosis International, 28, (8), 2017, p2409 - 2419
Neural Tube defects: Mechanisms of Folate in, editor(s)C.D. Karakochuk, K.C. Whitfield, T.J. Green and K. Kraemer , The Biology of the First 1000 Days, CRC Press, Taylor and Francis Group, 2017, pp123 - 136, [Molloy Annw M]
O'Sullivan F, Laird E, Kelly D, van Geffen J, van Weele M, McNulty H, Hoey L, Healy M, McCarroll K, Cunningham C, Casey M, Ward M, Strain JJ, Molloy AM, Zgaga L., Ambient UVB Dose and Sun Enjoyment Are Important Predictors of Vitamin D Status in an Older Population., Journal of Nutrition, 147, (5), 2017, p858-868.
Catena A, Muñoz-Machicao JA, Torres-Espínola FJ, Martínez-Zaldívar C, Diaz-Piedra C, Gil A, Haile G, Györei E, Molloy AM, Decsi T, Koletzko B, Campoy C, Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial., American Journal of Clinical Nutrition, 103, (1), 2016, p115-127
Bueno O, Molloy AM, Fernandez-Ballart JD, García-Minguillán CJ, Ceruelo S, Ríos L, Ueland PM, Meyer K, Murphy MM, Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status., Journal of Nutrition, 146, (1), 2016, p1-8
Pentieva K, Selhub J, Paul L, Molloy A.M, McNulty B, Ward M, Marshall B, Dornan J, Reilly R, Parle-McDermott A, Bradbury I, Ozaki M, Scott J.M, McNulty H, Evidence from a randomized trial that exposure to supplemental folic acid at recommended levels during pregnancy does not lead to increasedunmetabolized folicacid concentrations in maternal or cord blood, Journal of Nutrition, 146, (3), 2016, p494 - 500
Ozel A.B, Mcgee B, Siemieniak D, Jacobi P.M, Haberichter S.L, Brody L.C, Mills J.L, Molloy A.M, Ginsburg D, Li J.Z, Desch K.C, Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance, Journal of Thrombosis and Haemostasis, 14, (9), 2016, p1888-1898
SobczyÅ"ska-Malefora A, Pangilinan F, Plant G.T, Velkova A, Harrington D.J, Molloy A.M, Brody L.C, Association of a transcobalamin II genetic variant with falsely low results for the holotranscobalamin immunoassay, European Journal of Clinical Investigation, 46, (5), 2016, p434 - 439
Vaish S, White M, Daly L, Molloy AM, Staines A, Sweeney MR, Synthetic folic acid intakes and status in children living in Ireland exposed to voluntary fortification., American Journal of Clinical Nutrition, 103, (2), 2016, p512-518
O'Reilly S.L, McGlynn A.P, McNulty H, Reynolds J, Wasson G.R, Molloy A.M, Strain J.J, Weir D.G, Ward M, McKerr G, Scott J.M, Downes C.S, Folic acid supplementation in postpolypectomy patients in a randomized controlled trial increases tissue folate concentrations and reduces aberrant DNA biomarkers in colonic tissues adjacent to the former polyp site, Journal of Nutrition, 146, (5), 2016, p933 - 939
Szymczak S, Holzinger E, Dasgupta A, Malley J.D, Molloy A.M, Mills J.L, Brody L.C, Stambolian D, Bailey-Wilson J.E, r2VIM: A new variable selection method for random forests in genome-wide association studies, BioData Mining, 9, (1), 2016, p7
Coen RF, McCarroll K, Casey M, McNulty H, Laird E, Molloy AM, Ward M, Strain JJ, Hoey L, Hughes C, Cunningham CJ, The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders., Journal of geriatric psychiatry and neurology, 29, (6), 2016, p338-343
Vandermeer J.E, Carter T.C, Pangilinan F, Mitchell A, Kurnat-Thoma E, Kirke P.N, Troendle J.F, Molloy A.M, Munger R.G, Feldkamp M.L, Mansilla M.A, Mills J.L, Murray J.C, Brody L.C, Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts, American Journal of Medical Genetics, Part A, 170, (4), 2016, p1007 - 1016
E. Laird, M. C. Casey, M. Ward, L. Hoey, C. F. Hughes, K. Mccarroll, C. Cunningham, J. J. Strain, H. Mcnulty, A. M. Molloy, Dairy intakes in older Irish adults and effects on vitamin micronutrient status: Data from the TUDA study, The journal of nutrition, health & aging, 2016, p1-8
Molloy A.M, Pangilinan F, Mills J.L, Shane B, O'Neill M.B, McGaughey D.M, Velkova A, Abaan H.O, Ueland P.M, McNulty H, Ward M, Strain J.J, Cunningham C, Casey M, Cropp C.D, Kim Y, Bailey-Wilson J.E, Wilson A.F, Brody L.C, A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin, American Journal of Human Genetics, 98, (5), 2016, p869 - 882
Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun O, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM, Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults, J Nutr, 146, (9), 2016, p1801 - 1806
Keaveney E.M, Price R.K, Hamill L.L, Wallace J.M.W, McNulty H, Ward M, Strain J.J, Ueland P.M, Molloy A.M, Piironen V, Von Reding W, Shewry P.R, Ward J.L, Welch R.W, Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread, British Journal of Nutrition, 113, (3), 2015, p445 - 453
Bailey L.B, Stover P.J, McNulty H, Fenech M.F, Gregory J.F, Mills J.L, Pfeiffer C.M, Fazili Z, Zhang M, Ueland P.M, Molloy A.M, Caudill M.A, Shane B, Berry R.J, Bailey R.L, Hausman D.B, Raghavan R, Raiten D.J, Biomarkers of nutrition for development-Folate review, Journal of Nutrition, 145, (7), 2015, p1636S - 1680S
Clarke M, Ward M, Dickey W, Hoey L, Molloy A.M, Waldron L, Varghese A, McCann A, Blayney J.K, McNulty H, B-vitamin status in relation to bone mineral density in treated celiac disease patients, Scandinavian Journal of Gastroenterology, 50, (8), 2015, p975 - 984
Hopkins S.M, Gibney M.J, Nugent A.P, McNulty H, Molloy A.M, Scott J.M, Flynn A, Strain J.J, Ward M, Walton J, McNulty B.A, Impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults, American Journal of Clinical Nutrition, 101, (6), 2015, p1163 - 1172
McCarroll K, Beirne A, Casey M, McNulty H, Ward M, Hoey L, Molloy A, Laird E, Healy M, Strain JJ, Cunningham C, Determinants of 25-hydroxyvitamin D in older Irish adults., Age and Ageing, 44, (5), 2015, p847-853
, 18th Meeting of the Irish Society of Human Genetics, Friday 4th September 2015: Dublin City University., 2015
Ozaki M, Molloy AM, Mills JL, Fan R, Wang Y, Gibney ER, Shane B, Brody LC, Parle-McDermott A, The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake., Journal of Nutrition, 145, (10), 2015, 2207-2211
Carter T.C, Pangilinan F, Molloy A.M, Fan R, Wang Y, Shane B, Gibney E.R, Midttun Ø, Ueland P.M, Cropp C.D, Kim Y, Wilson A.F, Bailey-Wilson J.E, Brody L.C, Mills J.L, Common variants at putative regulatory sites of the tissue nonspecific alkaline phosphatase gene influence circulating pyridoxal 5'-phosphate concentration in healthy adults, Journal of Nutrition, 145, (7), 2015, p1386 - 1393
Deac O.M, Mills J.L, Shane B, Midttun O, Ueland P.M, Brosnan J.T, Brosnan M.E, Laird E, Gibney E.R, Fan R, Wang Y, Brody L.C, Molloy A.M, Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults, Journal of Nutrition, 145, (4), 2015, p701 - 707
Crider, KS, Devine, O, Hao, L, Dowling, NF, Li, S, Molloy, AM, Li, Z, Zhu, JH, Berry, RJ, Population red blood cell folate concentrations for prevention of neural tube defects: bayesian model, BMJ-BRITISH MEDICAL JOURNAL, 349, 2014, pg4554-
Nzila A, Okombo J, Molloy AM, Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate., Journal of Antimicrobial Chemotherapy, 69, (2), 2014, p323 - 330
Laird E, McNulty H, Ward M, Hoey L, McSorley E, Wallace JM, Carson E, Molloy AM, Healy M, Casey MC, Cunningham C, Strain JJ., Vitamin D deficiency is associated with inflammation in older irish adults., Journal of Clinical and Endocrinology Metabolism, 99, (5), 2014, p1807 - 1815
Ma Q, Ozel A.B, Ramdas S, McGee B, Khoriaty R, Siemieniak D, Li H.-D, Guan Y, Brody L.C, Mills J.L, Molloy A.M, Ginsburg D, Li J.Z, Desch K.C, Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels, Blood, 124, (20), 2014, p3155 - 3164
Devalia V, Hamilton MS, Molloy AM;the British Committee for Standards in Haematology, Guidelines for the diagnosis and treatment of cobalamin and folate disorders., British Journal of Haematology, 166, (4), 2014, p496-513
García-Minguillán C.J, Fernandez-Ballart J.D, Ceruelo S, Ríos L, Bueno O, Berrocal-Zaragoza M.I, Molloy A.M, Ueland P.M, Meyer K, Murphy M.M, Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine, Genes and Nutrition, 9, (6), 2014, p435-
Ludwig KU, Böhmer AC, Rubini M, Mossey PA, Herms S, Nowak S, Reutter H, Alblas MA, Lippke B, Barth S, Paredes-Zenteno M, Muñoz-Jimenez SG, Ortiz-Lopez R, Kreusch T, Hemprich A, Martini M, Braumann B, Jäger A, Pötzsch B, Molloy A, Peterlin B, Hoffmann P, Nöthen MM, Rojas-Martinez A, Knapp M, Steegers-Theunissen RP, Mangold E., Strong association of variants around FOXE1 and orofacial clefting., Journal of Dental Research, 93, (4), 2014, p376 - 378
Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Kay DM,Browne ML, McGrath EC, Abaan H, Sutton M, Kirke PN, Caggana M, Shane B, Scott JM, Brody LC. , Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects., BMC Medical Genetics , 15, (1), 2014, p102-
Mills J.L, Fan R, Brody L.C, Liu A, Ueland P.M, Wang Y, Kirke P.N, Shane B, Molloy A.M, Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects, American Journal of Clinical Nutrition, 100, (4), 2014, p1069 - 1074
Molloy AM, Einri CN, Jain D, Laird E, Fan R, Wang Y, Scott JM, Shane B, Brody LC, Kirke PN, Mills JL.., Is low iron status a risk factor for neural tube defects?, Birth Defects Research A Clinical and Molecular Teratology., 100, (2), 2014, p100 - 106
McNulty B, McNulty H, Marshall B, Ward M, Molloy AM, Scott JM, Dornan J, Pentieva K., Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters., American Journal of Clinical Nutrition , 98, (1), 2013, p92 - 98
Böhmer AC, Mangold E, Tessmann P, Mossey PA, Steegers-Theunissen RP, Lindemans J, Bouwman-Both M, Rubini M, Franceschelli P, Aiello V, Peterlin B, Molloy AM, Nöthen MM, Knapp M, Ludwig KU., Analysis of susceptibility loci for nonsyndromic orofacial clefting in a European trio sample., American Journal of Medical Genetics, 161, (10), 2013, p2545 - 2549
Desch KC, Ozel AB, Siemieniak D, Kalish Y, Shavit JA, Thornburg CD, Sharathkumar AA, McHugh CP, Laurie CC, Crenshaw A, Mirel DB, Kim Y, Cropp CD, Molloy AM, Kirke PN, Bailey-Wilson JE, Wilson AF, Mills JL, Scott JM, Brody LC, Li JZ, Ginsburg D, Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association., Proceedings of the National Academy of Sciences of the United States of America, 110, (2), 2013, p588-93
McGlynn AP, Wasson GR, O'Reilly SL, McNulty H, Downes CS, Chang CK, Hoey L, Molloy AM, Ward M, Strain JJ, McKerr G, Weir DG, Scott JM, Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum., The Journal of nutrition, 143, (1), 2013, p27-33
Scott JM, Molloy AM, The discovery of vitamin B(12)., Annals of nutrition & metabolism, 61, (3), 2012, p239-45
Molloy AM, Kappen C, Papers from the 7th International Neural Tube Defects Conference., Birth defects research. Part A, Clinical and molecular teratology, 94, (10), 2012, p747-8
Minguzzi S, Molloy AM, Peadar K, Mills J, Scott JM, Troendle J, Pangilinan F, Brody L, Parle-McDermott A, Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland., BMC medical genetics, 13, 2012, p29
Molloy AM, Genetic aspects of folate metabolism., Sub-cellular biochemistry, 56, 2012, p105-30
Wallace JM, McCormack JM, McNulty H, Walsh PM, Robson PJ, Bonham MP, Duffy ME, Ward M, Molloy AM, Scott JM, Ueland PM, Strain JJ, Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women., The British journal of nutrition, 108, (7), 2012, p1264-71
Lamarre SG, Molloy AM, Reinke SN, Sykes BD, Brosnan ME, Brosnan JT, Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration., American journal of physiology. Endocrinology and metabolism, 302, (1), 2012, pE61-7
O'Luanaigh C, O'Connell H, Chin AV, Hamilton F, Coen R, Walsh C, Walsh JB, Coakley D, Molloy A, Scott J, Cunningham CJ, Lawlor BA, Loneliness and vascular biomarkers: the Dublin Healthy Ageing Study., International journal of geriatric psychiatry, 27, (1), 2012, p83-8
Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Signore C, O'Leary VB, Chines P, Seay JM, Geiler-Samerotte K, Mitchell A, VanderMeer JE, Krebs KM, Sanchez A, Cornman-Homonoff J, Stone N, Conley M, Kirke PN, Shane B, Scott JM, Brody LC, Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects., BMC medical genetics, 13, 2012, p62
Scott J, Valente E, Molloy A, Holotranscobalamin: Not Ready for Prime Time., Clinical chemistry, 2012
Elizabeth A Yetley, Christine M Pfeiffer, Karen W Phinney, Regan L Bailey, Sheena Blackmore, Jay L Bock, Lawrence C Brody, Ralph Carmel, L Randy Curtin, Ramo"n A Durazo-Arvizu, John H Eckfeldt, Ralph Green, Jesse F Gregory III, Andrew N Hoofnagle, Donald W Jacobsen, Paul F Jacques, David A Lacher, Anne M Molloy, Joseph Massaro, James L Mills, Ebba Nexo, Jeanne I Rader, Jacob Selhub, Christopher Sempos, Barry Shane, Sally Stabler, Patrick Stover, Tsunenobu Tamura, Alison Tedstone, Susan J Thorpe, Paul M Coates, Clifford L Johnson, and Mary Frances Picciano, Biomarkers of vitamin B-12 status in NHANES: a roundtable summary 1-6, American Journal of Clinical Nutrition, 94, (1), 2011, p313S-321S
Murphy LE, Mills JL, Molloy AM, Qian C, Carter TC, Strevens H, Wide-Swensson D, Giwercman A, Levine RJ, Folate and vitamin B12 in idiopathic male infertility., Asian journal of andrology, 13, (6), 2011, p856-61
McNulty B, Pentieva K, Marshall B, Ward M, Molloy AM, Scott JM, McNulty H, Women's compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects., Human reproduction (Oxford, England), 26, (6), 2011, p1530-6
Robinson DJ, O'Luanaigh C, Tehee E, O'Connell H, Hamilton F, Chin AV, Coen R, Molloy AM, Scott J, Lawlor BA, Cunningham CJ, Vitamin B12 status, homocysteine and mortality amongst community-dwelling Irish elders., Irish journal of medical science, 180, (2), 2011, p451-5
Mills JL, Carter TC, Scott JM, Troendle JF, Gibney ER, Shane B, Kirke PN, Ueland PM, Brody LC, Molloy AM. , Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status? , American Journal of Clinical Nutrition, 94, (2), 2011, p495 - 500
Tighe P, Ward M, McNulty H, Finnegan O, Dunne A, Strain J, Molloy AM, Duffy M, Pentieva K, Scott JM, A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy, American Journal of Clinical Nutrition, 1-2, 2011, p1-8
Pfeiffer CM, Zhang M, Lacher DA, Molloy AM, Tamura T, Yetley EA, Picciano MF, Johnson CL. , Comparison of serum and red blood cell folate microbiologic assays for national population surveys. , Journal of Nutrition, 141, (7), 2011, p1402 - 1409
Sutton M, Mills JL, Molloy AM, Troendle JF, Brody LC, Conley M, Mc Donnell R, Scott JM, Kirke PN., Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects. , Birth Defects Research A: Clinical and Molecular Teratology, 91, (7), 2011, p610 - 615
Elizabeth A Yetley, Christine M Pfeiffer, Karen W Phinney, Zia Fazili, David A Lacher, Regan L Bailey, Sheena Blackmore, Jay L Bock, Lawrence C Brody, Ralph Carmel, L Randy Curtin, Ramo"n A Durazo-Arvizu, John H Eckfeldt, Ralph Green, Jesse F Gregory III, Andrew N Hoofnagle, Donald W Jacobsen, Paul F Jacques, Anne M Molloy, Joseph Massaro, James L Mills, Ebba Nexo, Jeanne I Rader, Jacob Selhub, Christopher Sempos, Barry Shane, Sally Stabler, Patrick Stover, Tsunenobu Tamura, Alison Tedstone, Susan J Thorpe, Paul M Coates, Clifford L Johnson, and Mary Frances Picciano, Biomarkers of folate status in NHANES: a roundtable summary 1-6, American Journal of Clinical Nutrition, 94, (1), 2011, 303S-312S
Stone N, Pangilinan F, Molloy AM, Shane B, Scott JM, Ueland PM, Mills JL, Kirke PN, Sethupathy P, Brody LC, Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes., PloS One, 6, (7), 2011, pe21851
Riedel BM, Molloy AM, Meyer K, Fredriksen A, Ulvik A, Schneede J, Nexø E, Hoff G, Ueland PM, Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women., The Journal of nutrition, 141, (10), 2011, p1784-90
Campoy C, Escolano-Margarit MV, Ramos R, Parrilla-Roure M, Csábi G, Beyer J, Ramirez-Tortosa MC, Molloy AM, Decsi T, Koletzko BV, Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age., The American journal of clinical nutrition, 94, (6 Suppl), 2011, p1880S-1888S
Robinson DJ, O'Luanaigh C, Tehee E, O'Connell H, Hamilton F, Chin AV, Coen R, Molloy AM, Scott J, Cunningham CJ, Lawlor BA, Associations between holotranscobalamin, vitamin B12, homocysteine and depressive symptoms in community-dwelling elders., International journal of geriatric psychiatry, 26, (3), 2011, p307-13
Valente E, Scott JM, Ueland PM, Cunningham C, Casey M, Molloy AM, Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B12 status in the elderly. , Clinical Chemistry, 57, (6), 2011, p856 - 863
Carter TC, Pangilinan F, Troendle JF, Molloy AM, VanderMeer J, Mitchell A, Kirke PN, Conley MR, Shane B, Scott JM, Brody LC, Mills JL, Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population., American journal of medical genetics. Part A, 155A, (1), 2011, p14-21
Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, Redett RA, Raymond G, Schwender H, Jin SC, Cooper ME, Dunnwald M, Mansilla MA, Leslie E, Bullard S, Lidral AC, Moreno LM, Menezes R, Vieira AR, Petrin A, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou YH, Chen PK, Wang H, Ye X, Huang S, Yeow V, Chong SS, Jee SH, Shi B, Christensen K, Melbye M, Doheny KF, Pugh EW, Ling H, Castilla EE, Czeizel AE, Ma L, Field LL, Brody L, Pangilinan F, Mills JL, Molloy AM, Kirke PN, Scott JM, Scott JM, Arcos-Burgos M, Scott AF, A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4., Nature Genetics, 42, (6), 2010, p525-529
Folate-Vitamin B12 Interrelationships: Links to Disease Risk in, editor(s)L.B. Bailey , Folate in Health and Disease, Second Edition, Boca Raton, FL, Taylor & Francis, 2010, pp381 - 408, [A.M. Molloy]
Carter TC, Molloy AM, Pangilinan F, Troendle JF, Kirke PN, Conley MR, Orr DJ, Earley M, McKiernan E, Lynn EC, Doyle A, Scott JM, Brody LC, Mills JL, Testing reported associations of genetic risk factors for oral clefts in a large Irish study population., Birth defects research. Part A, Clinical and molecular teratology, 88, (2), 2010, p84-93
Pangilinan F, Mitchell A, Vandermeer J, Molloy AM, Troendle J, Conley M, Kirke PN, Sutton M, Sequeira JM, Quadros EV, Scott JM, Mills JL, Brody LC, Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects., Journal of Medical Genetics, 47, (10), 2010, p677 - 685
N. Carroll , F. Pangilinan, A.M. Molloy, J. Troendle, J.L. Mills, P.N. Kirke, L.C. Brody, J.M. Scott, A. Parle-McDermott. , Analysis of the MTHFD1 promoter and risk of neural tube defects., Human Genetics, 125, (3), 2009, p247 - 256
Mitchell, A., Pangilinan, F., Van der Meer, J., Molloy, A.M., Troendle, J., Conley, M., Kirke, P.N., Scott, J.M., Brody, L.C., Mills, J.L., Uncoupling protein 2 polymorphisms as risk factors for NTDs, Birth Defects Research Part A: Clinical and Molecular Teratology, 85, (2), 2009, p156 - 160
Carroll, N., Pangilinan, F., Molloy, A.M., Troendle, J., Mills, J.L., Kirke, P.N., Brody, L.C., Scott, J.M., Parle-McDermott, A., Analysis of the MTHFD1 promoter and risk of neural tube defects, Human Genetics, 125, (3), 2009, p247 - 256
L. Hoey, H. McNulty, E.M. McCann, K.J. McCracken, J.M. Scott, B.B. Marc, A.M. Molloy, C. Graham, K.Pentieva, , Laying hens can convert high doses of folic acid added to the feed into natural folates in eggs providing a novel source of food folate, British Journal of Nutrition , 101, (2), 2009, p206 - 212
Molloy, A.M., Kirke, P.N., Troendle, J.F., Burke, H., Sutton, M., Brody, L.C., Scott, J.M., Mills, J.L., Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification, Pediatrics, 123, (3), 2009, p917 - 923
Molloy AM, Quadros EV, Sequeira JM, Troendle JF, Scott JM, Kirke PN, Mills JL., Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects, New England Journal of Medicine, 361, (2), 2009, p152-160
Parle-McDermott A, Pangilinan F, O'Brien KK, Mills JL, Magee AM, Troendle J, Sutton M, Scott JM, Kirke PN, Molloy AM, Brody LC., A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency, Human Mutation, 30, (12), 2009, p1650-1656
A. Mitchell, F. Pangilinan, J.Van der Meer, A.M. Molloy, J. Troendle, M. Conley , P.N. Kirke, J.M. Scott, L.C. Brody, J.L. Mills , Uncoupling protein 2 polymorphisms as risk factors for NTDs, Birth Defects Research Part A Clinical and Molecular Teratology, 85, (2), 2009, p156 - 160
Molloy, A.M., Brody, L.C., Mills, J.L., Scott, J.M., Kirke, P.N., The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects, Birth Defects Research (Part A), 85, (4), 2009, p285 - 294
Molloy, A.M., Quadros, E.V., Sequeira, J.M., Troendle, J.F., Scott, J.M., Kirke, P.N., Mills, J.L., Lack of association between folate-receptor autoantibodies and neural-tube defects, Obstetrical and Gynecological Survey, 64, (11), 2009, p716-718
A.M. Molloy, P.N. Kirke, L.C. Brody, J.M. Scott, J.L. Mills , Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development, Food and Nutrition Bulletin , 29, (2 Suppl), 2008, pS101 - S111
B. Bekaert, M.L. Cooper, F.R. Green, H. McNulty, K. Pentieva, J.M. Scott, A.M. Molloy, M.P. Rayman. , Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly., Molecular Nutrition and Food Research., 52, (11), 2008, p1324 - 1333
J.M. Wallace , M.P. Bonham , J. Strain , E.M. Duffy , P.J. Robson , M. Ward , H. McNulty , P.W.Davidson , G.J. Myers , C.F. Shamlaye , T.W. Clarkson, A.M. Molloy, J.M. Scott, P.M. Ueland. , Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study., American Journal of Clinical Nutrition, 87, (2), 2008, p391 - 397
F. Pangilinan, K. Geiler, J. Dolle, J. Troendle, D.A. Swanson, A.M. Molloy, M. Sutton, M. Conley , P.N. Kirke, J.M. Scott, J.L. Mills, L.C. Brody. , Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population., American Journal of Medical Genetics A. , 146A, (20), 2008, p2617 - 2625
R. Clarke , P. Sherliker, H. Hin, A.M. Molloy, E. Nexo, P.M. Ueland, K. Emmens, J.M. Scott, J.G. Evans. , Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK., British Journal of Nutrition, 100, (5), 2008, p1054 - 1059
J. Little, M. Gilmour, P.A. Mossey, D. Fitzpatrick, A. Cardy, J. Clayton-Smith, A. Hill, S.J. Duthie, A.E. Fryer, A.M. Molloy, J.M. Scott; ITS MAGIC Collaboration. , Folate and clefts of the lip and palate--a U.K.-based case-control study: Part II: Biochemical and genetic analysis, Cleft Palate Craniofacial Journal, 45, (4), 2008, p428 - 438
A.V. Chin, D.J. Robinson, H. O'Connell, F. Hamilton , I. Bruce, R. Coen, B. Walsh, D. Coakley, A. Molloy, J. Scott, B.A. Lawlor, C.J. Cunningham. , Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study. , Age and Ageing , 37, (5), 2008, p559 - 564
J.L. Mills, A.M. Molloy, A. Parle-McDermott, J.F. Troendle, L.C. Brody, M.R. Conley, C. Cox, F. Pangilinan, D.J. Orr, M. Earley, E. McKiernan, E.C. Lynn, A. Doyle, J.M. Scott, P.N. Kirke. , Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate., Birth Defects Research Part A Clinical and Molecular Teratology. , 82, (9), 2008, p636 - 643
Mary Rose Sweeney, Joseph McPartlin, and John Scott, Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum, BMC Public Health, 7, (41), 2007
L. Hoey, H. McNulty, N. Askin, A. Dunne, M. Ward, K. Pentieva, J. Strain, A.M. Molloy, C.A. Flynn, J.M. Scott. , Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults., American Journal of Clinical Nutrition, 86, (5), 2007, p1405 - 1413
A. Parle-McDermott, F. Pangilinan, J.L. Mills, P.N. Kirke, E.R. Gibney, J. Troendle, V.B. O'leary, A.M. Molloy, M. Conley, J.M. Scott, L.C. Brody. , The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population., American Journal of Medical Genetics A , 143, (11), 2007, p1174 - 1180
R. Clarke, P. Sherliker, H. Hin, E. Nexo, A.M. Hvas, J. Schneede, J. Birks, P.M. Ueland, K. Emmens, J.M. Scott, A.M. Molloy, J.G. Evans. , Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. , Clinical Chemistry , 53, (5), 2007, p963 - 970
M.M. Murphy, A.M. Molloy, P.M. Ueland, J.D. Fernandez-Ballart, J. Schneede, V. Arija, J.M. Scott. , Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring., Journal of Nutrition, 137, (8), 2007, p1863 - 1867
Molloy, A.M., Nutrition and metabolism, 2007, - 372-374
R. Clarke, J. Birks, E. Nexo, P.M. Ueland, J. Schneede, J. Scott, A. Molloy, J.G. Evans. , Low vitamin B-12 status and risk of cognitive decline in older adults., American Journal of Clinical Nutrition, 86, (5), 2007, p1384 - 1391
A. Parle-McDermott, P.N. Kirke, J.L.Mills, A.M. Molloy, C.Cox, VB. O'leary, F. Pangilinan, M. Conley, L. Cleary, L.C. Brody, J.M. Scott. , Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. , European Journal of Human Genetics , 14, (6), 2006, p768 - 772
V.B. O'Leary, F. Pangilinan, C. Cox, A. Parle-McDermott, M. Conley, A.M. Molloy, P.N. Kirke, J.L. Mills, L.C. Brody, J.M. Scott, Reduced folate carrier polymorphisms and neural tube defect risk. , Molecular and Genetic Metabolism. , 87, (4), 2006, p364 - 369
Molloy, A.M., Nutrition and metabolism, 2006, - 477-479
H. Hin, R. Clarke, P. Sherliker, W. Atoyebi, K. Emmens, J. Birks, J. Schneede, P.M. Ueland, E. Nexo, J. Scott, A. Molloy, M. Donaghy, C. Frost, J.G. Evans. , Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. , Age and Ageing, 35, (4), 2006, p416 - 422
M. Klingler, A. Blaschitz, C. Campoy, A. Cano, A.M. Molloy, J.M. Scott, G. Dohr, H. Demmelmair, B. Koletzko, G. Desoye. , The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. , British Journal of Nutrition, 96, (1), 2006, p182 - 190
H.McNulty, le R.C. Dowey, J.J. Strain, A. Dunne, M. Ward M, A.M. Molloy, L.B. McAnena, J.P. Hughes, M.Hannon-Fletcher, J.M. Scott. , Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism., Circulation, 113, (1), 2006, p74 - 80
P.M. Finglas, K. de Meer, A. Molloy, P. Verhoef, K. Pietrzik, H.J. Powers, D. van der Straeten, M. Jagerstad, G. Varela-Moreiras, T. van Vliet, R. Havenaar, J. Buttriss, A.J. Wright. , Research goals for folate and related B vitamin in Europe., European Journal of Clinical Nutrition, 60, (2), 2006, p287 - 294
Parle-McDermott, A., Kirke, P.N., Mills, J.L., Molloy, A.M., Cox, C., O'Leary, V.B., Pangilinan, F., Conley, M., Cleary, L., Brody, L.C., Scott, J.M., , Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population., European Journal of Human Genetics, 14, (6), 2006, p768 - 772
M.A. Mohammad, A. Molloy, J. Scott, L. Hussein. , Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yoghurt matrix. , International Journal of Food Science and Nutrition , 57, (7-8), 2006, p470 - 480
McNulty, H., Dowey, L.R.C., Strain, J.J., Ward, M., McAnena, L.B., Hughes, J.P., Hannon-Fletcher, M., (...), Scott, J.M., Response to letter regarding article, "riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism" [2] , 2006, - e66
A. Parle-McDermott, J.L. Mills, A.M. Molloy, N. Carroll, P.N. Kirke, C. Cox, M.R. Conley, F.J. Pangilinan, L.C. Brody, J.M. Scott. , The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels. , Molecular Genetics and Metabolism , 88, (3), 2006, p290 - 294
A. Parle-McDermott, J.L. Mills, P.N. Kirke, C. Cox, C.C. Signore, S. Kirke, A.M. Molloy, V.B. O'Leary, F.J. Pangilinan, C. O'Herlihy, L.C. Brody, J.M. Scott., MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruption placentae., American Journal of Medical Genetics A., 132, 2005, p365 - 368
V.B. O'Leary, J.L. Mills, A. Parle-McDermott, F. Pangilinan, A.M. Molloy, C. Cox, A. Weiler, M. Conley, P.N. Kirke, J.M. Scott, L.C. Brody; Birth Defects Research Group. , Screening for new MTHFR polymorphisms and NTD risk., American Journal of Medical Genetics A, 138, (2), 2005, p99 - 106
A. Parle-McDermott, F. Pangilinan, J.L. Mills, C.C. Signore, A.M. Molloy, A. Cotter, M. Conley, C. Cox, P.N. Kirke, J.M. Scott, L.C. Brody., A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss., Molecular Human Reproduction, 11, 2005, p477 - 480
S. Daly, A. Cotter, A. Molloy, J. Scott. , Homocysteine and folic acid: implications for pregnancy., Seminars in Vascular Medicine., 5, (2), 2005, p190-200
Molloy, A.M., The role of folic acid in the prevention of neural tube defects , Trends in Food Science and Technology, 16, (6-7), 2005, p241-245
V.B. O'Leary, J.L. Mills, F. Pangilinan, P.N. Kirke, C. Cox, M. Conley, A. Weiler, K. Peng, B. Shane, J.M. Scott, A. Parle-McDermott, A.M. Molloy, L.C. Brody; Members of the Birth Defects Research Group, Analysis of methionine synthase reductase polymorphisms for neural tube defects, Molecular Genetics and Metabolism, 85, (3), 2005, p220 - 227
D.A. Swanson, F. Pangilinan, J.L. Mills,P.N. Kirke, M. Conley, A. Weiler, T. Frey, A. Parle-McDermott, V.B. O'Leary, R.R. Seltzer, K.A. Moynihan, A.M. Molloy, H. Burke, J.M. Scott, L.C. Brody. , Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population., Birth Defects Research A: Clinical and Molecular Teratology , 73, (4), 2005, p239 - 244
A.M. Molloy, J.L. Mills, C. Cox, S.F. Daly, M. Conley, L.C. Brody, P.N. Kirke, J.M. Scott, P.M. Ueland. , Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery., American Journal of Clinical Nutrition , 82, (4), 2005, p836 - 842
A.L. Morkbak, R.M. Heimdal, K. Emmens, A. Molloy, A.M. Hvas, J. Schneede, R. Clarke, J.M. Scott, P.M. Ueland, E. Nexo. , Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project., Clinical Chemistry and Laboratory Medicine, 43, (10), 2005, p1058 - 1064
M.P. Hannon-Fletcher, N.C. Armstrong, J.M. Scott, K. Pentieva, I. Bradbury, M. Ward, J.J. Strain, A.A. Dunn, A.M. Molloy, M.A. Kerr, H. McNulty, Determining bioavailability of food folates in a controlled intervention study, American Journal of Clinical Nutrition, 80, 2004, p911 - 918
M.M. Murphy, J.M. Scott, V. Arija, A.M. Molloy, J.D. Fernandez-Ballart., Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight., Clinical Chemistry., 50, 2004, p1406 - 1412
A.M. Molloy, Genetic variation and nutritional requirements, World Review of Nutrition and Dietetics, 93, 2004, p153-63
P.N. Kirke, J.L. Mills, A.M. Molloy, L.C. Brody, V.B. O'Leary, L. Daly, S. Murray, M. Conley, P.D. Mayne, O. Smith, J.M. Scott. , Impact of the MTHFR C677T polymorphism on risk of neural tube defects:case-control study, British Medical Journal, 328, 2004, p1535 - 1536
A.M. Molloy , Folate and Homocysteine Interrelationships including genetics of the relevant enzymes., Current Opinions in Lipidology, 15, 2004, p49-57.
Pentieva K, McNulty H, Reichert R, Ward M, Strain JJ, McKillop DJ, McPartlin JM, Connolly E, Molloy A, Kramer K, Scott JM., The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men., Journal of Nutrition , 134, (3), 2004, p580 - 585
A. Parle-McDermott, E. J. McManus, J. L. Mills, V. B. O'Leary, F. Pangilinan, C. Cox, A. Weiler, A. M. Molloy, M. Conley, D. Watson, J. M. Scott, L. C. Brody and P. N. Kirke, Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects, Molecular Genetics and Metabolism, 80, (4), 2003, p463-8
A. M. Cotter, A. M. Molloy, J. M. Scott and S. F. Daly, Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia, American Journal of Obstetrics and Gynecology, 189, (2), 2003, p391-394
A. Parle-McDermott, J. L. Mills, P. N. Kirke, V. B. O'Leary, D. A. Swanson, F. Pangilinan, M. Conley, A. M. Molloy, C. Cox, J. M. Scott and L. C. Brody, Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects, Journal of Human Genetics, 48, (4), 2003, p190-193
V. B. O'Leary, J. L. Mills, P. N. Kirke, A. Parle-McDermott, D. A. Swanson, A. Weiler, F. Pangilinan, M. Conley, A. M. Molloy, M. Lynch, C. Cox, J. M. Scott and L. C. Brody, Analysis of the human folate receptor beta gene for an association with neural tube defects, Molecular genetics and metabolism, 79, (2), 2003, p129-133
L. C. Brody, M. Conley, C. Cox, P. N. Kirke, M. P. McKeever, J. L. Mills, A. M. Molloy, V. B. O'Leary, A. Parle-McDermott, J. M. Scott and D. A. Swanson, A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group, American Journal of Human Genetics, 71, (5), 2002, p1207-1215
V. B. O'Leary, A. Parle-McDermott, A. M. Molloy, P. N. Kirke, Z. Johnson, M. Conley, J. M. Scott and J. L. Mills, MTRR and MTHFR polymorphism: link to Down syndrome?, American Journal of Medical Genetics, 107, (2), 2002, p151-155
Molloy, A.M, Folate bioavailability and health, International Journal for Vitamin and Nutrition Research , 72, (1), 2002, 46-52
A. M. Molloy, J. L. Mills, J. McPartlin, P. N. Kirke, J. M. Scott and S. Daly, Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C-->T variant, American journal of obstetrics and gynecology, 186, (3), 2002, p499-503
S. Daly, J. L. Mills, A. M. Molloy, M. Conley, J. McPartlin, Y. J. Lee, P. B. Young, P. N. Kirke, D. G. Weir and J. M. Scott, Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age, QJM - Monthly Journal of the Association of Physicians , 95, (11), 2002, p733-740
A. M. Molloy and J. M. Scott, Folates and prevention of disease, Public Health Nutrition, 4, (2B), 2001, p601-609
Molloy, A.M., Role of genetic variation in establishing nutritional requirements: folate, a case in point., World Review of Nutrition and Dietetics, 89, 2001, p68-75
A. M. Cotter, A. M. Molloy, J. M. Scott and S. F. Daly, Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia, American journal of obstetrics and gynecology, 185, (4), 2001, p781-5
B. M. Ryan, A. M. Molloy, R. McManus, Q. Arfin, D. Kelleher, J. M. Scott and D. G. Weir, The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression, International journal of gastrointestinal cancer, 30, (3), 2001, p105-111
D. C. Shields, D. Ramsbottom, C. Donoghue, E. Pinjon, P. N. Kirke, A. M. Molloy, Y. H. Edwards, J. L. Mills, L. Mynett-Johnson, D. G. Weir, J. M. Scott and A. S. Whitehead, Association between historically high frequencies of neural tube defects and the human T homologue of mouse T (Brachyury), American Journal of Medical Genetics, 92, (3), 2000, p206-211
Weir DG, Molloy AM., Microvascular disease and dementia in the elderly: Are they related to hyperhomocysteinemia, 2000, - 859-860
Molloy, A.M., Is impaired folate absorption a factor in neural tube defects? Editorial, 2000, - 3-4
L. C. Brody, P. J. Baker, P. S. Chines, A. Musick, A. M. Molloy, D. A. Swanson, P. N. Kirke, S. Ghosh, J. M. Scott and J. L. Mills, Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects, Molecular Genetics and Metabolism, 67, (4), 1999, p324-333
A. M. Molloy, J. L. Mills, P. N. Kirke, D. G. Weir and J. M. Scott, Folate status and neural tube defects, BioFactors (Oxford, England), 10, (2-3), 1999, p291-294
J. L. Mills, P. N. Kirke, A. M. Molloy, H. Burke, M. R. Conley, Y. J. Lee, P. D. Mayne, D. G. Weir and J. M. Scott, Methylenetetrahydrofolate reductase thermolabile variant and oral clefts, American Journal of Medical Genetics, 86, (1), 1999, p71-74
D. C. Shields, P. N. Kirke, J. L. Mills, D. Ramsbottom, A. M. Molloy, H. Burke, D. G. Weir, J. M. Scott and A. S. Whitehead, The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother, American Journal of Human Genetics, 64, (4), 1999, p1045-1055
A. M. Molloy, D. G. Weir and J. M. Scott, Homocysteine, folate enzymes and neural tube defects, Haematologica, 84 Suppl , (EHA-4), 1999, p53-56
N. Mahmud, A. Molloy, J. McPartlin, R. Corbally, A. S. Whitehead, J. M. Scott and D. G. Weir, Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications, Gut, 45, (3), 1999, p389-94
A. S. Whitehead, A. M. Molloy, D. Ramsbottom, D. G. Weir, P. N. Kirke, J. L. Mills, P. M. Gallagher and J. M. Scott, Gene-gene interactions and neural tube defects, Clinical Genetics, 55, (2), 1999, p133-134
S. F. Daly, A. M. Molloy, J. L. Mills, Y. J. Lee, M. Conley, P. N. Kirke, D. G. Weir and J. M. Scott, The influence of 5,10 methylenetetrahydrofolate reductase genotypes on enzyme activity in placental tissue, British Journal of Obstetrics and Gynaecology, 106, (11), 1999, p1214-1218
A. M. Molloy, J. L. Mills, P. N. Kirke, A. S. Whitehead, D. G. Weir and J. M. Scott, Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: differences between the radioassay and microbiological assays, Clinical Chemistry, 44, (1), 1998, p186-188
Wald, N.J., Law, M., Jordan, R., Schorah, C.J., Daly, S., Mills, J., Molloy, A., (...), Scott, J., Folic acid food fortification to prevent neural tube defects (multiple letters) [6], 1998, - 834-835
A. M. Molloy, J. L. Mills, P. N. Kirke, D. Ramsbottom, J. M. McPartlin, H. Burke, M. Conley, A. S. Whitehead, D. G. Weir and J. M. Scott, Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor, American Journal of Medical Genetics, 78, (2), 1998, p155-159
A. M. Molloy, S. Daly, J. L. Mills, P. N. Kirke, A. S. Whitehead, D. Ramsbottom, M. R. Conley, D. G. Weir and J. M. Scott, Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations, Lancet, 349, (9065), 1997, p1591-3
S. Daly, J. L. Mills, A. M. Molloy, M. Conley, Y. J. Lee, P. N. Kirke, D. G. Weir and J. M. Scott, Minimum effective dose of folic acid for food fortification to prevent neural-tube defects, Lancet, 350, (9092), 1997, p1666-1669
A. M. Molloy and J. M. Scott, Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method, Methods in enzymology, 281, 1997, p43-53
D. Ramsbottom, J. M. Scott, A. Molloy, D. G. Weir, P. N. Kirke, J. L. Mills, P. M. Gallagher and A. S. Whitehead, Are common mutations of cystathionine beta-synthase involved in the aetiology of neural tube defects?, Clinical Genetics, 51, (1), 1997, p39-42
P. B. Young, S. Kennedy, A. M. Molloy, J. M. Scott, D. G. Weir and D. G. Kennedy, Lipid peroxidation induced in vivo by hyperhomocysteinaemia in pigs, Atherosclerosis, 129, (1), 1997, p67-71
J. L. Mills, J. M. Scott, P. N. Kirke, J. M. McPartlin, M. R. Conley, D. G. Weir, A. M. Molloy and Y. J. Lee, Homocysteine and neural tube defects, The Journal of nutrition, 126, (3), 1996, p756S-760S
P. N. Kirke, L. E. Daly, A. Molloy, D. G. Weir and J. M. Scott, Maternal folate status and risk of neural tube defects, Lancet, 348, (9019), 1996, p67-8
P. N. Kirke, J. L. Mills, A. S. Whitehead, A. Molloy and J. M. Scott, Methylenetetrahydrofolate reductase mutation and neural tube defects, Lancet, 348, (9033), 1996, p1037-8
A. S. Whitehead, P. Gallagher, J. L. Mills, P. N. Kirke, H. Burke, A. M. Molloy, D. G. Weir, D. C. Shields and J. M. Scott, A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects, QJM, 88, (11), 1995, p763-766
P. B. Young, S. Kennedy, A. M. Molloy, J. M. Scott, D. G. Weir and D. G. Kennedy, Effect of N2O treatment/vitamin B12 deficiency in pigs on tissue concentrations of odd-numbered, branched-chain fatty acids, International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition, 65, (4), 1995, p255-60
D. G. Kennedy, P. B. Young, S. Kennedy, J. M. Scott, A. M. Molloy, D. G. Weir and J. Price, Cobalt-vitamin B12 deficiency and the activity of methylmalonyl CoA mutase and methionine synthase in cattle, International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition, 65, (4), 1995, p241-247
M. McKeever, A. Molloy, P. Young, S. Kennedy, D. G. Kennedy, J. M. Scott and D. G. Weir, Demonstration of hypomethylation of proteins in the brain of pigs (but not in rats) associated with chronic vitamin B12 inactivation, Clinical science, 88, (4), 1995, p471-477
L. E. Daly, P. N. Kirke, A. Molloy, D. G. Weir and J. M. Scott, Folate levels and neural tube defects. Implications for prevention, JAMA, 274, (21), 1995, p1698-702
M. McKeever, A. Molloy, D. G. Weir, P. B. Young, D. G. Kennedy, S. Kennedy and J. M. Scott, An abnormal methylation ratio induces hypomethylation in vitro in the brain of pig and man, but not in rat, Clinical science , 88, (1), 1995, p73-79
J. M. Scott, A. M. Molloy, D. G. Kennedy, S. Kennedy and D. G. Weir, Effects of the disruption of transmethylation in the central nervous system: an animal model, Acta neurologica Scandinavica Supplementum, 154, 1994, p27-31
D. G. Kennedy, S. Kennedy, W. J. Blanchflower, J. M. Scott, D. G. Weir, A. M. Molloy and P. B. Young, Cobalt-vitamin B12 deficiency causes accumulation of odd-numbered, branched-chain fatty acids in the tissues of sheep, The British Journal of Nutrition, 71, (1), 1994, p67-76
J. M. Scott, D. G. Weir, A. Molloy, J. McPartlin, L. Daly and P. Kirke, Folic acid metabolism and mechanisms of neural tube defects, Ciba Foundation symposium, 181, 1994, p180-187
G. O'Connor, A. M. Molloy, L. Daly and J. M. Scott, Deriving a useful packed cell volume estimate from haemoglobin analysis, Journal of Clinical Pathology, 47, (1), 1994, p78-79
D. G. Kennedy, P. B. Young, W. J. Blanchflower, J. M. Scott, D. G. Weir, A. M. Molloy and S. Kennedy, Cobalt-vitamin B12 deficiency causes lipid accumulation, lipid peroxidation and decreased alpha-tocopherol concentrations in the liver of sheep, International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition, 64, (4), 1994, p270-276
K. C. Trimble, A. M. Molloy, J. M. Scott and D. G. Weir, The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage, Hepatology , 18, (4), 1993, p984-989
K. C. Trimble, M. G. Goggins, A. M. Molloy, F. Mulcahy, J. M. Scott and D. G. Weir, Vitamin B12 deficiency is not a cause of HIV-associated neuropathy, AIDS (London, England), 7, (8), 1993, p1132-1133
P. N. Kirke, A. M. Molloy, L. E. Daly, H. Burke, D. G. Weir and J. M. Scott, Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects, The Quarterly Journal of Medicine, 86, (11), 1993, p703-708
J. M. Scott, J. McPartlin, A. Molloy, H. McNulty, A. Halligan, M. Darling and D. G. Weir, Folate metabolism in pregnancy, Advances in experimental medicine and biology, 338, 1993, p727-32
A. M. Molloy, B. Orsi, D. G. Kennedy, S. Kennedy, D. G. Weir and J. M. Scott, The relationship between the activity of methionine synthase and the ratio of S-adenosylmethionine to S-adenosylhomocysteine in the brain and other tissues of the pig, Biochemical pharmacology, 44, (7), 1992, p1349-55
D. G. Kennedy, W. J. Blanchflower, J. M. Scott, D. G. Weir, A. M. Molloy, S. Kennedy and P. B. Young, Cobalt-vitamin B-12 deficiency decreases methionine synthase activity and phospholipid methylation in sheep, The Journal of Nutrition, 122, (7), 1992, p1384-1390
D. G. Weir, A. M. Molloy, J. N. Keating, P. B. Young, S. Kennedy, D. G. Kennedy and J. M. Scott, Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain, Clinical Science, 82, (1), 1992, p93-97
M. P. McKeever, D. G. Weir, A. Molloy and J. M. Scott, Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat, Clinical Science, 81, (4), 1991, p551-556
A. M. Molloy, D. G. Weir, G. Kennedy, S. Kennedy and J. M. Scott, A new high performance liquid chromatographic method for the simultaneous measurement of S-adenosylmethionine and S-adenosylhomocysteine. Concentrations in pig tissues after inactivation of methionine synthase by nitrous oxide, Biomedical Chromatography, 4, (6), 1990, p257-260
D. G. Weir, S. Keating, A. Molloy, J. McPartlin, S. Kennedy, J. Blanchflower, D. G. Kennedy, D. Rice and J. M. Scott, Methylation deficiency causes vitamin B12-associated neuropathy in the pig, Journal of Neurochemistry, 51, (6), 1988, p1949-1952
Molloy AM, Kirke P, Hillary I, Weir DG, Scott JM., Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects., Archives of disease in childhood, 60, (7), 1985, p660-665
Molloy AM, Ardill J, Tomkin GH., The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects., Diabetologia, 19, (2), 1980, p93-96
Molloy AM, Tomkin GH., Altered bile in diabetic diarrhoea., British Medical Journal, 2, (6150), 1978, p1462-1463
Non-Peer-Reviewed Publications
Molloy AM, Pentieva K, McNulty B, McNulty H., Reply to SW D'Souza et al, American Journal of Clinical Nutrition, 98, (6), 2013, p1598 - 1598
A.M. Molloy, J.M. Scott., Nutrition and metabolism., Current Opinions in Lipidology , 16, (4), 2005, p494-496
Research Expertise
Description
. The role of folate and vitamin B12 in pregnancy: This incorporates two principal areas; (1) the cause of folate responsive neural tube defects, in particular the nutritional, biochemical and genetic parameters associated with these disorders and (2) the effects of inadequate folate or vitamin B12 nutrition on complications of pregnancy and adverse pregnancy outcomes. The role of these vitamins in other congenital disorders including oro-facial clefts and congenital heart disease is an extension of this area of interest. . The uptake and utilisation of folates in normal and deficient states: A particular area of interest is the effect of genetic variants in folate related enzymes on folate status and metabolism. Research methods include cell culture studies and studies on nutritional status in human subjects, stratified according to a genotype of interest. . The development and application of new techniques in the analysis of folates and folate related metabolites. including HPLC methods, amino acid analysis, radioisotope methods, microbiological assays and cell culture technology. . Links between folate and vitamin B12; specifically, the influence of folate and vitamin B12 status on methylation reactions and s-adenosylmethionine metabolism.Recognition
Representations
Folic acid Review Group, organized by Food Safety authority of Ireland, Ireland
Expert Advisor WHO guideline development meeting on 'Optimal blood folate concentrations in women of reproductive age for prevention on Folate and Vitamin B12 deficiencies'
Research Ethics Committee, Coombe womens' Hospital
Editorial Board, British Journal of Nutrition
Expert Advisor at the Biomarkers of Nutrition for Development (BOND) Vitamin B12 Consultation, Office of Dietary Supplements, NIH, Washington,
Expert Advisor at the Biomarkers of Nutrition for Development (BOND) Vitamin B12 Consultation, Office of Dietary Supplements, NIH, Washington,
Expert Panel for the project "Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid" organized by the Office of Health Assessment and Translation, (NIEHS and ODS, National Institutes of Health, USA)
WHO Technical Consultant on Folate and Vitamin B12 Deficiencies
Expert advisor at the NHANES Folate and Vitamin B12 Assessment Round-Table meeting hosted by the Office of Dietary Supplements, NIH, Washington, 15th -16th July
Meeting Chair and Expert advisor at the World health Organization/Centers for Disease Control (WHO/CDC) Technical Consultation on "Optimal blood folate concentrations in women of reproductive age for prevention of neural tube defects" Atlanta, Georgia, USA .
Member of the planning committee (coordinator Professor Lindsay Allen, University of California, Davis) for Track 2 of the Micronutrient Forum Conference, held in Addis Ababa, Ethiopia, June 2014
Awards and Honours
Fellow, Trinity College Dublin
Global Experts Network on Spina Bifida and Hydrocephalus
Memberships
The Biochemical Society
The Nutrition Society
American society of Nutrition