Asst. Prof. Shigeki Nakagome
Assistant Professor, Psychiatry
- Research Institute:
Department of Psychiatry, Trinity Translational Medicine Institute (TTMI)
- Contact e-mail:
- Research Area(s):
BAYESIAN COMPUTATION; Bioinformatics; Evolution; Evolutionary Biology; Evolutionary genetics; GENE POLYMORPHISMS; GENE REGULATION; GENE-EXPRESSION; Genomes, Genomics; Genomic structure and function, molecular approaches to gene function; Genomics; Host-pathogen interaction; Human Evolution; Human Population Genetics; INFLAMMATORY BOWEL DISEASE; microbiome; MOLECULAR EVOLUTION; POPULATION GENETICS.
Research Description:
Our research team aims to understand the nature and function of host immune repertoires that provide the ability to discriminate pathogenic from symbiotic bacteria. Outcomes from our research will not only yield deeper insights into the host-microbiota crosstalk in IBD, but also pioneer personalized and targeted interventions to control this interaction for prevention and treatment of IBD. Taking advantage of our expertise in quantitative genetics and its application to high-throughput sequencing, we develop statistical and computational approaches to immunogenomics profiling on patients affected by IBD. Our research aims to describe (i) the patterns of inter-individual variation in the host immunity and bacterial activity, (ii) the processes of immune development that ends up with the breakdown of host tolerance to gut bacteria, and (iii) the impacts of past selective pressures during human evolution on an individual's ability to adapt to its own intestinal environments.
