Prof. Orla Sheils
Professor in Molecular Diagnostics, Histopathology
- Research Institute:
Discipline of Histopathology; Trinity Translational Medicine Institute (TTMI)
- Contact e-mail:
- Research Area(s):
Autoimmunity; Bioinformatics; Biomedical ethics; Cancer genetics and cell biology including metastasis; Cervical cancer; Commercialisation of scientific research; Diagnostics; Endocrine function and disease; Environmental Carcinogenesis; Foetal, maternal and neonatal physiology; Gene transcription in human cancer; Gynaecology oncology; HASHIMOTO THYROIDITIS; Immunochemistry and immunogenetics; Inflammatory bowel disease; Intra and intercellular signalling; Medical Law; Medical Sciences, Research; Membrane and protein trafficking; Oncogenes, apoptosis and tumour development; Oral diseases and Oral medicine; Oral pathology; Pathophysiology; Prostate cancer; Quantitative and molecular genetics; Regulatory methods of gene expression; RET ONCOGENE ACTIVATION; RNA processing, stability and degradation; Role of oestrogens in age related urogenital diseases; SIGNAL TRANSDUCTION; TAQMAN RT-PCR; Thyroid Cancer; Tumour immunology and immunotherapy; TYROSINE PHOSPHORYLATION; Virology and viral pathogenesis.
Research Description:
My research focuses on elucidating the underlying mechanisms of human disease with a focus on cancer and metastasis of solid tumors. This work is translated into novel assays for better diagnosis and prognostication of patients' disease. I have made seminal discoveries into the pathobiology of cancers including thyroid and cervix, which have resulted in major changes to the way patients are treated. I am a founder member of several international consortia working to establish novel sequencing technologies as routine diagnostic testing regimens in clinical laboratories. My research has been published in international journals at the highest levels and has been incorporated into fundamental pathology textbooks.
