Professor Laure Marignol
Professor In, Radiation Therapy
Biography
Laure Marignol, PhD is Professor in Radiation Biology at the Discipline of Radiation Therapy in the School of Medicine. She is an Elected Fellow of the University. Head of Research for her Discipline, she drove the creation of the Applied Radiation Therapy Trinity (ARTT) research group, while leading her Translational Radiobiology and Molecular Oncology research laboratory. Dr. Marignol has worked for over 12 years on the problem of the selective destruction of cancer cells with ionising radiation, through the design in vitro models, the molecular classification of disease, and innovations in therapeutic approaches. Her work mostly focused on prostate cancer owing to her close relationship with the Urology Department at St James's Hospital. With close to 100 peer-reviewed research works, she is best known for her earlier work on understanding the molecular impact of oxygenation levels on the response of prostate tumours to radiation. Her research also focuses on novel approaches to improving cell lethality by radiation. She is serving as Chair of the Irish Radiation Research Society and advisor to the Environmental Protection Agency (EPA). She sits on the Radiobiology committee of the European Society for Radiotherapy and Oncology (ESTRO) and joined the Faculty of their course in Basic Clinical Radiobiology. She holds an editorial position with Nature Scientific Reports. Recipient of the highly competitive St Luke's Young Investigator Award of the Royal Irish Academy of Medicine, she was awarded grant funding from the Irish Cancer Society and Science Foundation Ireland. Dr. Marignol is also known for her ability to train students and Health Care Professionals on the research process. She received a Teaching Award from the Dean of the Faculty of Health Sciences to develop her 5-step research guide into the online Trinity Research Education Environment (TREE). Priding herself in being fair, a value most appreciated by her students and peers, Dr. Marignol has developed her career through the combination of a love of learning, a need to be challenged and an awareness that kindness is key to progress. She believes in embracing the possibility of a second chance and takes pleasure in exploring a hunch, in hearing the perspective of others and in encouraging the scientific community to continue to explore her field. She lives near Dublin with her husband and three young children. She regularly visits her family in Avignon, France.
Publications and Further Research Outputs
Peer-Reviewed Publications
Townsend, L. and Dunne, J. and Sui, J. and Sanchez Perez, C. and McElheron, M. and Reid, C. and McCormack, W. and Bergin, C. and Fleming, C. and O'Farrelly, C. and Brady, G. and Conlon, N., Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants, Clinical Immunology, (110371), 2024
Ward M.E., Geary U., Brennan R., Vining R., McKenna L., O'Connell B., Bergin C., Byrne D., Creagh D., Fogarty M., Healy U., McDonald G., Ebiele M., Crane M., Pham M.-K., Bendechache M., Bezbradica M., Liang J., Doyle B., Guilfoyle J., Shuhaiber A., McDonald N., A systems approach to managing the risk of healthcare acquired infection in an acute hospital setting supported by human factors ergonomics, data science, data governance and AI, Ergonomics, 2024
McDermott A., Murphy N., Reddin C., Bergin C., The experiences of individuals living with HIV in Ireland attending out-patient physiotherapy, AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 36, (3), 2024, p368 - 373, p368-373
Collier, R. and Leech, M. and Marignol, L. and Gaffney, J. and Leijenaar, R. and Malone, C., Creating a 3D-printed pelvic phantom to explore the impact of Magnetic Resonance (MR) scanner noise in radiomics analysis, a technical note., Annals of 3D Printed Medicine, 13, (100143), 2024
Ripoll-Viladomiu, I. and Prina-Mello, A. and Movia, D. and Marignol, L., Extracellular vesicles and the â six Rsâ in radiotherapy, Cancer Treatment Reviews, 129, (102799), 2024
SK Zazzera , C Poole & L Marignol, Investigating the Needs and Concerns of Lesbian, Gay, Bisexual, Transgender, Queer, or Questioning Cancer Patients, Journal of Homosexuality, 2024
Marignol, L. and McMahon, S.J., Research Trends in the Study of the Relative Biological Effectiveness: A Bibliometric Study, Radiation Research, 202, (2), 2024, p177-184
Marignol, L. and Pugh, C.W., Time, location and function of hypoxia-inducible factors are critical to therapeutic tumour response, BMJ Oncology, 3, (1), 2024
Grimes, D.R. and Rassamegevanon, T. and Marignol, L., In silico analysis of overall survival with YBX1 in male and female solid tumours, Scientific Reports, 14, (1), 2024
Hughes G., Cunney R., Mockler D., Talento A.F., Leary A.O., Bergin C., Use of complexity theory to inform antimicrobial stewardship: a scoping review, Journal of Hospital Infection, 2024
O'Brien K.K., Erlandson K.M., Brown D.A., Carusone S.C., Vera J.H., Bergin C., Avery L., Bayoumi A.M., Hanna S.E., Harding R., Solomon P., Clair-Sullivan N.S., O'Shea N., Murray C., Boffito M., Da Silva G., Torres B., McDuff K., Davis A.M., Episodic disability questionnaire (EDQ) measurement properties among adults living with HIV in Canada, Ireland, United Kingdom, and United States, BMC Infectious Diseases, 24, (1), 2024
Harris E, Marignol L., Prehabilitation for Patients with Cancer Undergoing Radiation Therapy: a Scoping Review., Clinical oncology (Royal College of Radiologists (Great Britain)), 36, (4), 2024, p254-264
Vens, C. and van Luijk, P. and Vogelius, R.I. and El Naqa, I. and Humbert-Vidan, L. and von Neubeck, C. and Gomez-Roman, N. and Bahn, E. and Brualla, L. and Böhlen, T.T. and Ecker, S. and Koch, R. and Handeland, A. and Pereira, S. and Possenti, L. and Rancati, T. and Todor, D. and Vanderstraeten, B. and Van Heerden, M. and Ullrich, W. and Jackson, M. and Alber, M. and Marignol, L., A joint physics and radiobiology DREAM team vision â" Towards better response prediction models to advance radiotherapy, Radiotherapy and Oncology, 196, (110277), 2024
Temperley H.C., Mac Curtain B.M., O'Sullivan N.J., Mulhall C., Temperley T.S., Mehigan B.J., Larkin J.O., McCormick P.H., Kerr C., Gallagher D., Bergin C., Gillham C., Kelly M.E., Factors Influencing Outcomes and Survival in Anal Cancer, Current Oncology, 31, (9), 2024, p5151 - 5163, p5151-5163
Leech, M. and Leijenaar, R.T.H. and Hompland, T. and Gaffney, J. and Lyng, H. and Marignol, L., Exploring Hypoxia in Prostate Cancer With T2-weighted Magnetic Resonance Imaging Radiomics and Pimonidazole Scoring, Anticancer Research, 43, (1), 2023, p351-357
Marignol L., Generation of Radioresistant Prostate Cancer Cells., Methods in molecular biology (Clifton, N.J.), 2645, 2023, p129-138
Liu T, Dahle MA, Lystad MH, Marignol L, Karlsen M, Redalen KR., In vitro and in vivo characterization of [64Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors., European journal of nuclear medicine and molecular imaging, 50, (12), 2023, p3576-3588
Forde E, Robert C, Leech M, Marignol L., Spatial Resampling Combined with Intensity Discretization Improves Reproducibility of Radiomic Features of the Parotid Gland. (e-poster #604, European Congress of Medical Physics, Dublin, Ireland, August 2022, 2022
Radio-resistant in vitro models for cancer research in, editor(s)Adriele Prina-Mello Dania Movia , Methods in Cancer Cell Culture, Springer Nature, 2022, [Laure Marignol]
Forde E, Leech M, Robert C, Heron E, Marignol L, Influence of Inter-Observer Delineation Variability on Radiomic Features of the Parotid Gland, Physica Medica, (82), 2021, p240 - 248
Leech M, Leijenaar R, Hompland T, Gaffney J, Lyng H, Marignol L, Exploring hypoxia in prostate cancer with T2-weighted MRI radiomics and pimonidazole scoring, Radiotherapy and Oncology, ESTRO 2021, Madrid, Spain, 161, Elsevier, 2021, ppS1526 - S1527
Adrian Fuentes-Bonachera, Darragh Waters, A. Meunier, Rustom P. Manecksha, Laure Marignol, Thomas H. Lynch, Sex in Bladder cancer research: an overview, SN Comprehensive Clinical Medicine, 2021
Armelle Meunier, Laure Marignol, The radiotherapy cancer patient: female inclusive, but male dominated, International Journal of Radiation Biology, 2020, p1--21
Michelle Leech, Sarah Osman, Suneil Jain, Laure Marignol, Mini review: Personalization of the radiation therapy management of prostate cancer using MRI-based radiomics, Cancer Letters, 2020
Bates, Mark, Boland, Anna, McDermott, Niamh, Marignol, Laure, YB-1: The key to personalised prostate cancer management?, Cancer Letters, 2020
Sarah Barrett, Michelle Leech, Dr Laure Marignol, Time trend analysis of target volume auto-contouring in locally advanced NSCLC over the course of RT, ESTRO 2020, Vienna, Austria, 2020
Darragh Waters , Adrian Fuentes-Bonachera , Armelle Meunier , Rustom P. Manecksha, Laure Marignol and Thomas H. Lynch, Kidney Cancer Research: Sex-Inclusive but Sex-Unspecific, Clinical Oncology and Research, 2020
Clerkin, James and Connor, Kate and Sweeney, Kieron and White, Kieron and Shiels, Liam and Maher, Stephen and Marignol, Laure and Prehn, Jochen H. M. and O'Brien, David and Byrne, Annette, ESTABLISHING A CLINICALLY RELEVANT MODEL OF MESENCHYMAL GLIOBLASTOMA (GBM) TO STUDY RESPONSE TO STANDARD OF CARE TREATMENT AND IMMUNE CHECKPOINT INHIBITION (ICI)., 25th Virtual Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), ELECTR NETWORK, NOV 19-21, 2020, 22, (2), 2020, pp230
James Clerkin, Kate Connor, Kieron Sweeney, Kieron White, Stephen G. Maher, Laure Marignol, Jochen Prehn , David O'Brien, Annette T. Byrne, Establishing a clinically relevant model of Glioblastoma in young and aged mice, encompassing standard of care treatment and immune checkpoint inhibition (ICI, Irish Association for Cancer Research , Galway, February 2020, 2020
Barrett S , Simpkin AJ , Walls G , Leech M , Marigno Ll , Geometric and dosimetric evaluation of a commercially available auto-segmentation tool for gross tumour volume delineation in locally advanced Non-Small Cell Lung Cancer: a feasibility study, Journal of Clinical Oncology, 2020
Wei Ang, Laure Marignol, Pro-con of proton: dosimetric advantages of intensity-modulation over passive scatter for thoracic malignancies , Technical Innovations & Patient Support in Radiation Oncology, 2020
Elizabeth Forde, Michelle Leech, Charlotte Robert, Elizabeth Heron, Laure Marignol, Influence of Inter-Observer Delineation Variability on Radiomic Features of the Parotid Gland, Radiotherapy and Oncology, ESTRO2020, Online, August 2020, 2020
Laure Marignol, Radiobiology of particles therapy: principles and latest advances, ESTRO meets Asia , Singapore, 2019, European Society for Radiotherapy and Oncology
S Inder, M Bates, N Ni Labhrai, N McDermott, J Schneider, G Erdmann, T Jamerson, AN Flores, A Prina-Mello, P Thirion, PR Manecksha, D Cormican, S Finn, T Lynch, L Marignol, Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance, Scientific Reports, 9, 2019, p1 - 12
Laure Marignol, Molecular radiation response of breast cancer: advances and clinical potential, ESTRO meets Asia , Singapore, 6-8th December, 2019, European Society for Radiotherapy and Oncology
Barrett S, Thirion P, Harper D, Simpkin A, Leech M, Hickey K, Ryan L, Marignol L, Dosimetric impact of uncorrected systematic yaw rotation in VMAT for peripheral lung SABR, . Reports of Practical Oncology & Radiotherapy, 24, (6), 2019, p520 - 527
Marignol L., Predicting Treatment Outcomes: The Case for Hypoxia Gene Signatures., EBioMedicine, 2018
Sarah Barrett, Gerard G. Hanna, Laure Marignol, An overview on personalisation of radiotherapy prescriptions in locally advanced non-small cell lung cancer: Are we there yet?, Radiotherapy and Oncology, 128, (3), 2018, p520 - 533
Griffin F., Marignol L., Therapeutic potential of melatonin for breast cancer radiation therapy patients, International Journal of Radiation Biology, 94, (5), 2018, p472 - 477
Wall V, Marignol L, ElBeltagi N., Image-Guided Radiotherapy in Paediatrics: A Survey of International Patterns of Practice., Journal of medical imaging and radiation sciences, 49, (3), 2018, p265-269
Elbeltagi M.N., Wall V., Marignol L., Planning target volume (PTV) margin practice patterns in adults and paediatrics among the Paediatric Radiation Oncology Society (PROS) members: An international survey, Journal of Radiotherapy in Practice, 17, (4), 2018, p373 - 376
Glynn A, Marignol L, Forde E, Focal therapy: A treatment option for localized prostate cancer? , Advances in Modern Oncology Research, 2018
Mascan, B. and Marignol, L., Aspirin in the management of patients with prostate cancer undergoing radiotherapy: Friend or Foe?, Anticancer Research, 38, (4), 2018, p1897-1902
Mascan, B., Marignol, L., Aspirin in the management of patients with prostate cancer undergoing radiotherapy: Friend or Foe?, Anticancer Research, 38, (4), 2018, p1897-1902
Elbeltagi, M.N., Wall, V., Marignol, L., Planning target volume (PTV) margin practice patterns in adults and paediatrics among the Paediatric Radiation Oncology Society (PROS) members: An international survey, Journal of Radiotherapy in Practice, 17, (4), 2018, p373-376
Inder, S, Bates, M, McDermott, N, Saluzzo, J, Ni Labhrai, N , Schneider, J, Erdmann, G, Lynch, , Marignol, L, Lessons from isogenic models of radioresistant prostate cancer cells, 37th Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO), Barcelona, SPAIN, 2018
Fiona Griffin, Laure Marignol, Therapeutic potential of melatonin for breast cancer radiation therapy patients, International Journal of Radiation Biology, 2018, p1--6
Wall, V., Marignol, L., ElBeltagi, N., Image-Guided Radiotherapy in Paediatrics: A Survey of International Patterns of Practice, Journal of Medical Imaging and Radiation Sciences, 49, (3), 2018, p265-269
Sarah Caufield, Laure Marignol, Gerard Menezes, Claire Poole, Nomograms are key decision making tools in prostate cancer radiation therapy, Urologic Oncology: Seminars and Original Investigations, 36, (6), 2018, p283 - 292
McDermott N, Inder S, Schneider J, Erdmann G,Meunier A., Lynch T, Marignol L, Radioresistance profiling identifies Notch-3 signalling as a molecular switch to molecular radiation response of prostate cancer cells , 15th International Wolfsberg Meeting, Switzerland, 2017
Inder, S., O'Rourke, S., McDermott, N., (...), Lynch, T., Marignol, L. , The Notch-3 receptor: A molecular switch to tumorigenesis?, Cancer treatment reviews, 60, 2017, p69-76
Fitzpatrick C, Lynch O, Marignol L., 68Ga-PSMA-PET/CT Has a Role in Detecting Prostate Cancer Lesions in Patients with Recurrent Disease., Anticancer research, 37, (6), 2017, p2753-2760
McDermott, N. and Meunier, A. and Jameson, T. and Mansour, A. and Haynes, C. and Flores, A. and O'Callaghan, A. and Marignol, L., Novel molecular radiobiology for personalised prostate cancer radiotherapy, RADIOTHERAPY AND ONCOLOGY, 123, (1), 2017, pS200
Haruna, F., Lipsett, A., Marignol, L. , Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis., Anticancer research, 37, (10), 2017, p5343-5353
McDermott, N., Meunier, A., Wong, S., Buchete, V., Marignol, L., Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs, Clinical and Translational Radiation Oncology, 2, 2017, p63-68
McDermott N,Inder S, Schneider J, Erdmann G, Meunier A., Lynch T, Marignol L, Identifying a novel molecular switch of the radiation response of prostate cancer cells, Radiation Research Society Annual Meeting, Cancun, Mexico, October 15-18, 2017
Inder, S. and Bates, M. and McDermott, N. and Domad, J. and Schneider, J. and Erdmann, G. and Finn, S. and Manecksha, R. P. and Lynch, T. H. and Marignol, L., Profiling of radioresistant prostate cancer cells identifies deregulation of key protein, BJU INTERNATIONAL, 120, (2, SI), 2017, p24
Fitzpatrick, C., Lynch, O., Marignol, L., 68Ga-PSMA-PET/CT has a role in detecting prostate cancer lesions in patients with recurrent disease, Anticancer Research, 37, (6), 2017, p2753-2760
Hutchinson, J., Marignol, L. , Clinical Potential of Statins in Prostate Cancer Radiation Therapy., Anticancer research, 37, (10), 2017, p5363-5372
Laure Marignol, Gene editing: How this technique can be used to study radiation responses?, 2017, S1 - S1pp
O'Brien, R. and Marignol, L., The Notch-1 receptor in prostate tumorigenesis, Cancer Treatment Reviews, 56, 2017, p36-46
Marignol, L., Notch signalling: The true driver of small cell lung cancer?, Translational Cancer Research, 6, 2017, pS1191-S1196
McDermott N., Meunier A., Wong S., Buchete V., Marignol L., Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs, Clinical and Translational Radiation Oncology, 2, 2017, p63 - 68
Samsuri, N.A.B. and Leech, M. and Marignol, L., Metformin and improved treatment outcomes in radiation therapy â" A review, Cancer Treatment Reviews, 55, 2017, p150-162
Inder, S. and Bates, M. and McDermott, N. and Domad, J. and Schneider, J. and Erdmann, G. and Finn, S. and Manecksha, R. P. and Lynch, T. H. and Marignol, L., Identification of a protein signature of radioresistance in a prostate cancer model, The British Association for Urological Surgeons, 120, 2017, pp24-24
Devine, A. and Marignol, L., Meta-analysis: can amifostine reduce chemoradiotherapy and radiotherapy toxicity in advanced NSCLC?, RADIOTHERAPY AND ONCOLOGY, 119, (1), 2016, pS964
McDermott, N.; Meunier, A.; Haynes, C.; Flores, A.; O'Callaghan, A.; Marignol, L., Therapeutic potential of the YB-1/Notch-3 interaction in prostate cancer, 35th Scientific Meeting of the European Society for Radiotherapy and Oncology (ESTRO), Turin, Italy, 2016
Michelle Leech, John Gaffney, Laure Marignol, Improving non-invasive detection of prostate cancer using diffusion-weighted MRI, Advances in Modern Oncology Research , 2, (6), 2016
Meunier A., Flores A., McDermott N., Rivera-Figueroa K., Perry A., Lynch T., Redalen K., Marignol L., Hypoxia regulates Notch-3 mRNA and receptor activation in prostate cancer cells, Heliyon, 2, (5), 2016
Wall, V. and Marignol, L. and Elbeltagi, M. N., Radiotherapy in Paediatrics: A Survey of International Patterns of Practice of Image Guided Radiation Therapy and Planning Target Volume, 63, 2016, ppS64-S64
Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397
Devine A, Marignol L, Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis., Anticancer research, 36, (1), 2016, p5-12
McDermott N., Meunier A., Mooney B., Nortey G., Hernandez C., Hurley S., Hurley S., Lynam-Lennon N., Barsoom S., Bowman K., Marples B., Jones G., Marignol L., Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells, Scientific Reports, 6, 2016
Lawlor H, Meunier A, McDermott N, Lynch TH, Marignol L, Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells., Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36, (8), 2015, p6019-28
Moran DC, Marignol L, Fagan AJ, Dunne R, Perry AS, O'Driscoll D, Gaffney E, Lynch TH, Meaney JFM, Hollywood DH, Threshold-based parametric analysis of diffusion-weighted magnetic resonance imaging at 3.0 Tesla to identify men with prostate cancer, Adv Mod Oncol Res , 1, (2), 2015, p141 - 150
McDermott, N. and Meunier, A. and Hernandez, C. and Bowman, K. J. and Jones, G. D. and Marignol, L., Identification of a miRNAs signature of radioresistance in a prostate cancer model, 75, 2015
Lim D, Quah DS, Leech M, Marignol L, Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer., Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015
Dullea A, Marignol L, MGMT testing allows for personalised therapy in the temozolomide era., Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015
McDermott, N. and Meunier, A. and Hernandez, C. and Bowman, K. J. and Jones, G. D. and Marignol, L., Identification of MiRNAs associated with radioresistance in a prostate cancer model, RADIOTHERAPY AND ONCOLOGY, 115, (1), 2015, pS670
, A novel Interactive Health Communication Application (IHCA) for parents of children with long-term conditions: development, implementation and feasibility assessment, Inform Health Soc Care, 2015
Floyd, R. and McDermott, N. and Meunier, A. and Marignol, L., Radiosensitisation properties of PI3K/AKT inhibitor GDC-0941 in prostate cancer cells, RADIOTHERAPY AND ONCOLOGY, 115, (1), 2015, pS572
McLaughlin, J., Marignol, L., Radiotherapy scheduling using prime numbers, Journal of Radiotherapy in Practice , 13, (3), 2014, p317-321
Marignol, L., Targeting notch in prostate cancer - Combination is the key, 11, (7), 2014
Kelada O, Marignol L, Erythropoietin-stimulating agents and clinical outcomes in metastatic breast cancer patients with chemotherapy-induced anemia: a closed debate?, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35, (6), 2014, p5095-100
Martin, L.M., Marples, B., Lynch, T.H., Hollywood, D., Marignol, L., Erratum to Exposure to low dose ionizing radiation: Molecular and clinical consequences [Cancer Lett. 338 (2) (2013) 209-218], 349, (1), 2014
Flores AN, McDermott N, Meunier A, Marignol L, NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer., Nature reviews. Urology, 11, (9), 2014, p499-507
Scientific Report, Nature, [eds.], 2014
Azmi A, Dillon RA, Borghesi S, Dunne M, Power RE, Marignol L, O'Neill BD, Active surveillance for low-risk prostate cancer: diversity of practice across Europe., Irish journal of medical science, 2014
Martin LM, Marples B, Davies AM, Atzberger A, Edwards C, Lynch TH, Hollywood D, Marignol L, DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells., Cancer letters, 2013
Vajda A, Marignol L, Barrett C, Madden SF, Lynch T, Hollywood D, Perry AS, Gene expression in prostate cancer: the importance of the endogenous control. , The Prostate, 2013
McDermott N, Meunier A, Lynch T, Hollywood D, Marignol L, Isogenic radiation resistant cell lines: Development and Validation strategies., International journal of radiation biology, 2013
Perry, A.S. and O'Hurley, G. and Raheem, O.A. and Brennan, K. and Wong, S. and O'Grady, A. and Kennedy, A.M. and Marignol, L. and Murphy, T.M. and Sullivan, L. and Barrett, C. and Loftus, B. and Thornhill, J. and Hewitt, S.M. and Lawler, M. and Kay, E. and Lynch, T. and Hollywood, D., Erratum: Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer (International Journal of Cancer (2013) 132:8 (1771-80) DOI: 10.1002/ijc.27798)), International Journal of Cancer, 132, (11), 2013
Bolton, E. M. and Moran, D. and Meunier, A. and Vajda, A. and O'Kelly, F. and Thurman, J. and O'Connor, R. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A. S., Epigenetic profiling in urine for the detection of aggressive prostate cancer, 100, 2013, pp63-63
Martin LM, Marples B, Lynch TH, Hollywood D, Marignol L, Exposure to Low Dose Ionizing Radiation: Molecular and Clinical Consequences., Cancer letters, 2013
Davies, A.M., Vajda, A., Ryan, S.L., Marignol, L., New approaches to cell based assays for high content screening and analysis, 18, (3), 2013, p23-28
Marignol L, Rivera-Figueroa K, Lynch T, Hollywood D, Hypoxia, notch signalling, and prostate cancer., Nature reviews. Urology, 10, (7), 2013, p405-13
Bolton, E. M. and Moran, D. C. and Meunier, A. and O'Kelly, F. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A. S., Real time expression analysis of a microRNA signature of prostate cancer in prostate cell lines and tissue specimens, 100, 2013, pp63-63
Schoenherr D, Krueger SA, Martin L, Marignol L, Wilson GD, Marples B, Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: A cell line study in four glioblastoma multiforme (GBM) cell lines., International journal of radiation biology, 2013
Mongan, A. M. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J. N. and Reynolds, J. V., Obesity and radiosensitivity status influence genomic instability events: Anaphase bridge formation and spindle assembly checkpoint gene expression in oesophageal cancer, 100, 2013, pp48-48
Røe K, Bratland A, Vlatkovic L, Ragnum HB, Saelen MG, Olsen DR, Marignol L, Ree AH, Hypoxic Tumor Kinase Signaling Mediated by STAT5A in Development of Castration-Resistant Prostate Cancer., PloS one, 8, (5), 2013, pe63723
Mongan, A. M. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and O'Farrell, N. J. and Pidgeon, G. and O'Sullivan, J. and Reynolds, J. V., Obesity fuels genomic instability and radioresistance in oesophageal cancer, 182, 2013, ppS38-S38
Mongan, A. M. and Reynolds, J. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J., Obesity Status Influence Nuclear Instability Events: Anaphase Bridge Formation and Spindle Assembly Checkpoint Gene Expression in Oesophageal Cancer, 181, 2012, ppS152-S153
James C. Forde, Laure Marignol, Ophelia Blake, Ted McDermott, Ronald Grainger, Vivien E. Crowley, Thomas H. Lynch, Standardization of assay methods reduces variability of total PSA measurements: an Irish study, 2012
Azmi, Aini and Dillon, Ruth and Marignol, Laure and Borghesi, Simona and Dunne, Mary and Power, Richard and O'Neill, Brian, Active surveillance for low-risk prostate cancer: Practice across Europe, Journal of Clinical Oncology, 30, (5), 2012
O'Kelly F, Marignol L, Meunier A, Lynch TH, Perry AS, Hollywood D, MicroRNAs as putative mediators of treatment response in prostate cancer., Nature reviews. Urology, 2012
Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, Barrett C, Loftus B, Thornhill J, Hewitt SM, Lawler M, Kay E, Lynch T, Hollywood D, Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer., International journal of cancer. Journal international du cancer, 2012
Roe, K. and Mikalsen, L. T. G. and van der Kogel, A. J. and Bussink, J. and Lyng, H. and Ree, A. H. and Marignol, L. and Olsen, D. R., DCEMRI IN ASSESSMENT OF TUMOR NEOVASCULARIZATION AFTER ANDROGEN-DEPRIVATION IN EXPERIMENTAL PROSTATE CANCER: CORRELATION TO QUANTITATIVE IMMUNOHISTOCHEMISTRY, RADIOTHERAPY AND ONCOLOGY, 102, (1), 2012, pS68
O'Kelly, F. and Perry, A. S. and Meunier, A. and Wong, S. and Hollywood, D. and Marignol, L. and Lynch, T. H., Over-expression of a novel microRNA, miR-24, affects prostate cancer cell growth and proliferation, and contributes to radio-senstivity of prostate cancer cells in vitro, 11, (1), 2012, ppE849-U790
Røe K, Mikalsen LT, van der Kogel AJ, Bussink J, Lyng H, Ree AH, Marignol L, Olsen DR, Vascular responses to radiotherapy and androgendeprivation therapy in experimental prostate cancer., Radiation oncology (London, England), 7, (1), 2012, p75
Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012
Bolton, E. and Moran, D. and Meunieur, A. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A., Real Time Expression Analysis of a Microrna Signature of Prostate Cancer in Prostate Cell Lines and Tissue Specimens, 181, 2012, ppS169-S170
Lynam-Lennon, Niamh and Reynolds, John V. and Marignol, Laure and Sheils, Orla M. and Pidgeon, Graham P. and Maher, Stephen G., miR-31 modulates tumor sensitivity to radiation in esophageal cancer by regulation of DNA repair genes, CANCER RESEARCH, 71, (8), 2011
Hennessey, D. and Coffey, M. and Lynch, T. and Lawler, M. and Hollywood, D. and Marignol, L., Adaptation to low oxygenation levels modify the radioresponse of prostate cancer cells in vitro, 98, (6), 2011, ppE8-E8
Forde JC, Maginn EN, McNamara G, Martin LM, Campiani G, Williams DC, Zisterer D, McElligott AM, Lawler M, Lynch TH, Hollywood D, Marignol L, Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro., Cancer biology & therapy, 11, (4), 2011, p421-8
Forde, J. C. and Perry, A. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L., Downregulation of HIF-1 A and lowered TUBB3 expression levels leads to preferential sensitivity of hypoxic prostate cancer cells tol docetaxel, 98, (6), 2011, ppE8-E8
Hennessey D, Martin LM, Atzberger A, Lynch TH, Hollywood D, Marignol L, Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells., Urologic oncology, 1, 2011
Moran, D. and Marignol, L. and Fagan, A. and Hollywood, D. and Meaney, J. and Lynch, T., Functional endorectal MRI at 3 Tesla for the detection and staging of prostate cancer: Correlation with prostatectomy specimens, 180, 2011, ppS269-S270
Foley R, Marignol L, Keane JP, Lynch TH, Hollywood D., Androgen hypersensitivity in prostate cancer: molecular perspectives on androgen deprivation therapy strategies, Prostate, 71, (5), 2011
Forde, James and Blake, Ophelia and Marignol, Laure and McDermott, T. E. D. and Grainger, Ronald and Crowley, Vivion and Lynch, Thomas, DEMONSTRATION OF THE VARIABILITY OF THE DIFFERENT TOTAL PSA ASSAYS CURRENTLY IN USE THROUGHOUT IRISH HOSPITALS, JOURNAL OF UROLOGY, 185, (4, S), 2011, pE817
Forde, J. C. and Maginn, E. and McElligott, A. M. and Martin, L. M. and Williams, D. C. and Zisterer, D. and Lawler, M. and Hollywood, D. and Lynch, T. H. and Marignol, L., AN IN VITRO INVESTIGATION OF THE CYTOTOXIC AND RADIO-SENSITISING PROPERTIES OF A NOVEL MICROTUBULE TARGETING AGENT, PBOX-15, IN HYPOXIC PROSTATE CANCER CELL LINES, European Urology Supplements, EAU, 10, (2), 2011, pp292-292
Lennon, N. Lynam and Reynolds, J. V. and Marignol, Laura and Sheils, O. M. and Pidgeon, G. P. and Maher, S. G., MiR-31 modulates tumour sensitivity to radiation in oesophageal cancer, 180, 2011, ppS276-S276
Mongan, A. M. and Reynolds, J. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J., Levels of obesity influences a nuclear instability event: Anaphase bridge formation in oesophageal cancer, 180, 2011, ppS262-S262
Vajda A, Marignol L, Foley R, Lynch TH, Lawler M, Hollywood D, Clinical potential of gene-directed enzyme prodrug therapy to improve radiation therapy in prostate cancer patients., Cancer treatment reviews, 37, (8), 2011, p643-54
Forde, J. C. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L. and Marignol, L., Investigation of the cytotoxic properties of a novel microtubule-targeting compound, PBOX-15, in hypoxic prostate cancer cell lines, Bju International, 106, (1), 2010, pp52-53
Foley R, Marignol L, Keane JP, Lynch TH, Hollywood D, Comment on "Androgen-hypersensitive preclinical model of prostate cancer" by Kawata et al., The Prostate, 71, (6), 2010, p559 - 560
Forde, J. C. and Maginn, E. and McElligott, A. M. and Martin, L. M. and Williams, D. C. W. and Zisterer, D. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L., RADIOSENSITIZATION OF HYPOXIC PROSTATE CANCER CELL LINES USING A NOVEL MICROTUBULE TARGETING AGENT: PBOX-15, Irish Journal of Medical Science, IACR, 179, 2010, ppS372-S372
Hennessey, D. and Martin, L. and Hollywood, D. and Lynch, T. H. and Marignol, L., EXPOSURE TO REDUCED OXYGENATION FOLLOWING RADIATION EXPOSURE ENHANCES THE SURVIVAL OF PROSTATE CANCER CELLS IN VITRO: IMPLICATIONS FOR RADIATION THERAPY DELIVERY, Irish Medical Science Journal , IACR, 179, 2010, ppS351-S351
Marignol, L., 5-STEP GUIDE TO THE MANAGEMENT OF A RESEARCH PROJECT, RADIOTHERAPY AND ONCOLOGY, 96, (1), 2010, pS164
Martin L, Coffey M, Lawler M, Hollywood D, Marignol L, DNA mismatch repair and the transition to hormone independence in breast and prostate cancer., Cancer letters, 291, (2), 2010, p142-9
Martin LM, Marples B, Coffey M, Lawler M, Lynch TH, Hollywood D, Marignol L, DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data., Cancer treatment reviews, 36, (7), 2010, p518-27
Keane, J. P. and Foley, R. and Marignol, L. and Hollywood, D. and Lynch, T. H., THE EFFECT OF CALPAIN ACTIVATION IN THE 22Rv1 PROSTATE CANCER CELL LINE, 179, 2010, ppS350-S350
Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG, Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma., Radiation research, 174, (6), 2010, p703 - 711
Kelada, O. J. and Marignol, L., DOES THE USE OF ERYTHROPOIETIN-STIMULATING AGENTS IN BREAST CANCER PATIENTS WITH CHEMOTHERAPY-INDUCED ANAEMIA IMPACT ON CLINICAL OUTCOMES ? A CRITICAL REVIEW OF THE LITERATURE, RADIOTHERAPY AND ONCOLOGY, 96, (1), 2010, pS578
Forde JC, Perry AS, Brennan K, Martin LM, Lawler MP, Lynch TH, Hollywood D, Marignol L, Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells., Urologic oncology, 1, 2010
Forde, J. C. and Blake, O. and Casey, R. G. and Marignol, L. and McDermott, T. E. and Grainger, R. and Crowley, V. E. and Lynch, T. H., THE INTER-HOSPITAL VARIABILITY OF 6 DIFFERENT PSA ASSAY KITS CURRENTLY IN USE THROUGHOUT IRELAND, Irish Journal of Medical Science, IACR, 179, 2010, ppS372-S372
Marignol, L. and Martin, L. and Coffey, M. and Lawler, M. and Lynch, T. and Hollywood, D., REDUCED OXYGENATION DOES NOT PROTECT ALL PRO STATE CANCER CELLS FROM RADIATION: A NEW ROLE FOR HYPOXIA IN RADIATION THERAPY?, RADIOTHERAPY AND ONCOLOGY, 96, (1), 2010, pS596
Perry, Antoinette S. and O'Hurley, Gillian and Raheem, Omer A. and O'Grady, Anthony and Kennedy, Anne -Marie and Barrett, Ciara and Marignol, Laure and Murphy, Therese M. and Sullivan, Linda and Loftus, Barbara and Hewitt, Stephen M. and Kay, Elaine and Lawler, Mark, Epigenetic discovery screen identifies SFRP2 as a novel biomarker of high grade prostate cancer, CANCER RESEARCH, 70, (8), 2010
Thomas, A. Z. and Foley, R. and Marignol, L. and Hollywood, D. and Lynch, T. and Lawlor, M., The effect of the HIF-1 alpha C1772T heterozygous genotype on prostate cancer risk and HIF-1 alpha expression in prostate tissue, 97, 2010, pp3-4
Raheem, O. A. and Perry, A. S. and Kennedy, A. M. and Murphy, T. M. and Foley, R. and Marignol, L. and Suillvan, L. and Loftus, B. and Lawler, M. and Lynch, T. H., INVESTIGATING PROMOTER METHYLATION OF WNT SIGNALLING ANTAGONISTS IN PROSTATE CANCER, EUROPEAN UROLOGY SUPPLEMENTS, 9, (2), 2010, p310
Marignol, L., Foley, R., Southgate, T.D., Coffey, M., Hollywood, D., Lawler, M., Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro., The Journal of Gene Medicine , 11, (2), 2009, p169-179
Raheem, O. A. and Powell, A. and Kennedy, A. M. and Murphy, T. and Foley, R. and Marignol, L., Investigation into methylation of the Secreted Frizzled Related Proteins (SFRP) family of Wnt antagonists in prostate cancer, 103, 2009, pp19-20
Lynn Martin, Brian Marples, Mary Coffey, Mark Lawler, Donal Hollywood, Laure Marignol, Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity., Radiation Research, 172, (4), 2009, p405 - 413
Foley R, Marignol L, Thomas AZ, Cullen IM, Perry AS, Tewari P, O'Grady A, Kay E, Dunne B, Loftus B, Watson WR, Fitzpatrick JM, Woodson K, Lehman T, Hollywood D, Lynch TH, Lawler M, The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers., Cancer biology & therapy, 8, (2), 2009, p118-24
Vajda, Alice and Marignol, Laure and Foley, Ruth and Hollywood, Donal and Lawler, Mark, Hypoxia, androgen and radiation-inducible suicide gene therapy for the treatment of prostate cancer, 20, (11), 2009, pp1519-1519
D'Arcy, F. and Foley, R. and Perry, A. and Marignol, L. and Lawler, M. and Gaffney, E. and Watson, R. G. W. and Fitzpatrick, J. M. and Lynch, T. H., No evidence of XMRV in irish prostate cancer patients with the R462q mutation, 7, (3), 2008, pp271-271
Marignol L, Coffey M, Lawler M, Hollywood D., Hypoxia in prostate cancer: a powerful shield against tumour destruction?, Cancer Treatment Reviews, 34, (4), 2008, p313-327
Marignol L, Robson T, McCarthy HO, Worthington J, Murray MM, Hollywood D, Lawler M, Hirst DG., The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?, Journal of Gene Medicine, 10, (9), 2008, p1032-1038
Marignol, L. and Foley, R. and Southgate, T. D. and Coffey, M. and Hollywood, D. and Lawler, M., Hypoxia-inducible suicide gene therapy approach radiosensitises prostate cancer cells, 100, 2007, pp32-32
Thomas, A. Z. and Marignol, L. and Foley, R. and Perry, A. and Tewari, P. and O'Grady, T. and Kay, E. and Dunne, B. and Loftus, B. and Hollywood, D. and Lynch, T. and Lawler, M., Enhanced expression of hypoxia markers in cell lines and in clinical specimens of malignant prostate tissue: A factor in disease progression?, 100, 2007, pp40-41
D'Arcy, F. and Foley, R. and Perry, A. and Marignol, L. and Gaffney, E. and Dunne, B. and Lawler, M. P. and Watson, R. W. G. and Fitzpatrick, J. M. and Lynch, T. H., RNASEL and its role in Irish prostate cancer patients, 100, 2007, pp12-13
Martin, L. and Marignol, L., Sequence effect on the survival of prostate cancer cells may potentiate daily radiation therapy delivery, 84, 2007, ppS281-S281
Foley, R. and Marignol, L. and Lawler, M., Prodrug activation therapy kills prostate cancer cells in a three-dimensional culture model, 100, 2007, pp24-24
Thomas, A. Z. and Marignol, L. and Foley, R. and Perry, A. and Tewari, P. and O'Grady, T. and Kay, E. and Dunne, B. and Loftus, B. and Hollywood, D. and Lynch, T. and Lawler, M., Enhanced expression of hypoxia markers in cell lines and in clinical specimens of malignant prostate tissue: A factor in disease progression?, 100, 2007, pp40-41
Marignol L, Coffey M, Hollywood D, Lawler M., Radiation to Control Transgene Expression in Tumors., Cancer Biological Therapy, 6, (7), 2007, p1005 - 1012
Traynor, S. and Gilham, C. and Foley, R. and Fairbairn, L. J. and Southgate, T. D. and Worthington, J. and Coffey, M. and Hollywood, D. and Lawler, M. and Marignol, L., Utilising a hypoxia-inducible suicide gene therapy strategy in combination with radiation to target prostate cancer cells, 81, 2006, ppS477-S477
Marignol L, Lawler M, Coffey M, Hollywood D., Achieving Hypoxia-Inducible Gene Expression in Tumors., Cancer Biological Therapy, 4, (4), 2005, p359-364.
Research Expertise
Description
Radiobiology is a field of science that emerged from our ability to treat diseases with ionising radiation. I am intrigued by the complexity of the biological effects of radiation and feel compelled to pick at the puzzle. Cancer patients will never meet me, but I rejoice in the opportunity to help radiation Oncologists solve their challenges in ensuring that each patient can receive the best treatment for their disease. Radiobiology's pillars were defined by a few great and I feel privileged to have brought this field to Trinity and to both disseminate its legacy and contribute to its future in Ireland and internationally. I have extensively studied the impact of tumour microenvironmental factors on the biology of prostate tumours. My PhD work demonstrated that hypoxia could enable control therapeutic gene expression and has enabled others to purse this approach. My subsequent participation in the debate on the protective effect of hypoxia after radiation exposure, and its ability to affect the efficacy of commonly used chemotherapeutic agents shaped my transformation into an independent PI. My first grant selected for radioresistant prostate cancer cells, establishing a unique model to characterise the molecular mechanisms of the radiation response. I tested the prognostic potential of miRNAs, small, non-coding RNAs that negatively regulate gene expression, and identified novel miRNAs regulating radioresistance in prostate cancer cells. I proposed that the signalling pathways that regulate several cancer cells capabilities such as Notch and YB-1 as key to the survival of cancer cells to radiation, and identified deregulation of the Notch-3 receptor across cell line models of advancing disease stages and in patient specimens of high grade disease. My second grant examined the commercial potential of these findings for the development of a novel diagnostic test. Along the way, I have learnt that heterogeneity will prevail, and diversity in approaches is essential. I pushed the boundaries, investigating physical properties (functional imaging), learning the practical challenges of delivering radiotherapy, enabling my colleagues at the Discipline of Radiation Therapy to progress their research in the process. Together, we have demonstrated that molecular imaging techniques, such as magnetic resonance imaging (MRI), can advance our ability to assess prostate cancer; we have explored the impact of patient rotation on the treatment of lung cancer patient with radiotherapy. More recently I have questioned the potential impact of the differences between male and female biology. My next research objective is to enable my discoveries to inform both the prediction of clinical outcome to a radiotherapy treatment and the optimisation of a radiotherapy protocol to best treat tumours. To do so, next propose to devise a novel strategy for the selective generation of a large amount of DNA damage in single cancer cells. I have already, amongst others, demonstrated increased cell survival capacity in response to radiation exposure is associated with both reduced induction of DNA DSB and increased DNA repair capacity. While efforts to modify the DNA damage response are yielding encouraging results, this work will leverage my expertise and network, generate new opportunities while maintain the reputation of my unique, internationally recognised radiobiology lab and extended research group.Projects
- Title
- Tumours have a sex: impact on the response of bladder cancer to therapy.
- Summary
- Years of experience with ionising radiation and/or chemical poisons has taught us that damaging the genome - cutting the DNA molecule that it consists of - can block the development of cancer and delay death. This project will investigate sex as a biological variable affecting the ability of bladder cancer to overcome these cuts and escape destruction. This work will compare the presence of the tools required to repair this damage in female and male bladder cancer patients, experimentally manipulate their availability and test their relationship with the cancer development process in laboratory models.
- Funding Agency
- PhD Provost Award 2021
- Date From
- October 2021
- Date To
- October 2025
- Title
- Creating the next-generation Cancer cell DNA damaging agent
- Summary
- Our insufficient, biologically challenged or poorly targeted ability to generate fatal DNA damage in cancer cells is recognised as an underlying major limiting factor to therapeutic efficacy of current cancer treatments. While efforts to modify the DNA damage response are yielding encouraging results, few novel anti-cancer DNA damaging agents are emerging. This project aims to create the next generation cancer cell DNA damaging agent.
- Date From
- October 2020
- Date To
- Present
- Title
- Tumours have a sex: Impact on disease development and treatment response.
- Summary
- The issue of sex bias or sex dismorphism in science is rapidly gaining momentum. Sex is a variable that affects several biological functions including both the innate and adaptive immune systems, the mode of stress-induced cell death and pain responses. Sex-specific studies have highlighted that drugs may affect males and females differently. But the impact of sex on the radiation response remains largely unstudied. Our lab investigates the impact of sex as a biological variable in the response to anti-cancer treatment. This work would involve the generation of in vitro survival curves using both female and male cancer cell lines, the review of published and recorded clinical data, and a solid evaluation of the potential sex-specific differences in the behaviour of cancer cells.
- Date From
- October 2019
- Date To
- Ongoing
- Title
- Development of a Companion diAgnostic teSt for radiotheraPy prostAte canceR patients (CASPAR)
- Summary
- There is an unmet need to develop companion diagnostic tests that can guide patients and their clinicians through the treatment decision process. This project propose assesses a novel protein for its prognostic and therapeutic potential in high risk radiotherapy prostate cancer patients. The long-term focus of CASPAR is to develop a novel companion diagnostic test and therapeutic combination that can allow personalized prescription of radiotherapy for these patients.
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/01/2017
- Date To
- 31/128/2017
- Title
- Prognosis potential of miRNAs in high risk radiotherapy prostate cancer patients
- Summary
- Failure to identify tumours with a radioresistant phenotype in the 1,000+ Irish prostate cancer patients/year receiving radiation therapy (RT) is associated with recurrence and decreased overall survival in approximatively 300-400 of these men, particularly those with localised Gleason 8-10 prostate carcinoma. This study aims to identify a miRNA panel that can be detected in diagnostic tissue biopsy specimen from high-risk patients, which will assist the identification of the 30-50% who are at greater risk of biochemical failure following RT.
- Funding Agency
- Irish Cancer Society
- Date From
- 01 December 2012
- Date To
- 01 December 2016
- Title
- Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?
- Summary
- Oxygen is essential for optimal cytotoxicity of radiation therapy. In the absence of oxygen at the time of radiation exposure, cell survival is commonly expected to increase by up to three-fold. We proposed that the proportion of cells completely deprived of oxygen within tumours may not be sufficiently large to be clinically significant and hypothesised that the surrounding hypoxic cells in fact may govern tumour response to radiotherapy. To test this hypothesis, this study proposed to re-examine the radioresponse of hypoxic prostate cancer cells and determine the consequences of these potentially clinically relevant oxygen levels.
Recognition
Representations
Specialist Examiner (Radiobiology), Royal College of Radiologists FRCR examinations, UK
Member, History Committee, Radiation Research Society (USA).
Prostate Cancer Research UK. Invited member, Research Advisory committee.
Editor, Clinical and Translational Radiation Oncology (Elsevier)
Invited member, The Advisory Committee for Radiation Oncology Practice (ACROP) committee.
Clinical and Translational Radiation Oncology, Editorial Board Member.
Environmental Protection Agency (EPA) Advisory Committee (Ireland) ( Minister Appointed Radiobiology advisor)
Cancers (Special Issue Invited Guest Editor)
European Society for Radiotherapy and Oncology, ESTRO 2021 Conference Scientific Advisory Group (Radiobiology Symposium development, Session chair, Abstract Reviewer)
Basic Radiobiology Teaching Course, European Society for Radiotherapy and Oncology (Faculty member)
University of Manchester, UK (PhD external Examiner)
Royal College of Surgeons in Ireland, Faculty of Radiologists, FRCR Radiobiology Examination Preparation course (Radiation Oncology Registrars) (Radiobiology Course development, Instructor (Radiobiology); Tutor (Statistics))
University College Dublin, School of Medicine. Professional Certificate in Radiation Safety. (Curriculum developer, Instructor).
Protocol for treatment interruption Compensation, Lung Radiation Therapy due to COVID-19 (Radiobiology Advisor)
European Society for Radiotherapy and Oncology, ESTRO 2020 Conference Scientific Advisory Group (Radiobiology Symposium development, Session chair, Abstract Reviewer)
Irish Radiation Research Society (Chair)
European Society for Radiotherapy and Oncology, Radiobiology Committee (Invited Member)
St Luke's Radiation Oncology Network - Radiobiology Steering Committee (Invited member)
Nature Scientific Reports (Editor)
Journal Reviewer - Molecular Biology Reports Urology Advances in Radiation Oncology Experimental and Therapeutic Medicine Physics and Imaging in Radiation Oncology technical innovations and patient support in radiation oncology International Journal of Molecular Medicine Cancers
The Wellcome - HRB Irish Clinical Academic Training Programme (Supervisor)
Grant Reviewer - Medical Research Council (UK), COST Action (European Commission), EIT Health COVID Rapid response (European Commission), ERA PerMed (European Commission)
Journal reviewer - Frontiers Oncology Clinical breast cancer Journal of Clinical Medicine Cells Molecular Oncology Oncology reports Oncology letters Oncotarget
GANIL (Grand Accélérateur d'Ions Lourds) - Application Reviewing Committee member
Queen's University Belfast, Northern Ireland (PhD external examiner)
Irish Radiation Research Society (Deputy Chair)
Irish Radiation Research Society (Secretary)
Grant Reviewer - Leading Fellows Postdoc Programme (The Netherlands)
University of Cape Town, South Africa (PhD external examiner)
Irish Radiation Research Society (Treasurer)
International Exchange, Global Health Disparities Research Training Program, Division of Public Health, Icahn School of Medicine at Mount Sinai, New York, USA. (Invited Mentor)
University of New South Wales, Australia (PhD external examiner)
Awards and Honours
Election to Fellowship, Trinity College Dublin
Faculty of Health Sciences, Dean's Research Award
Cancer Immunology Stimulus Award
GANIL (Grand Accélérateur d'Ions Lourds) Beam Access Award
Faculty of Health Sciences, Dean's Teaching Award
Science Foundation Ireland, TIDA
Early Career Investigator Award, Radiation Research Society (USA)
Irish Cancer Society, Prostate Cancer Project Grant
Travel Award, Radiation Research Society, USA
6th St Lukes Young Investigator Award
Early investigator award, Association for Radiation Research (UK)
Memberships
Irish Radiation Research Society
European Society for Radiotherapy and Oncology (ESTRO)
Radiation Research Society (USA)
Irish Association for Cancer Research