Professor Joseph Keane
Professor of Medicine 1955, Clinical Medicine
Professor of Medicine 1955, School Office - Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
Yennemadi AS, Jordan N, Diong S, Keane J, Leisching G., The link between dysregulated immunometabolism and vascular damage: Implications for the development of atherosclerosis in SLE and other rheumatic diseases., The Journal of rheumatology, 2024, pjrheum.2023-0833
Roche SM, Ottewill C, Mulpeter R, Brown K, Grant C, Fraughen DD, Dolan L, Gleeson LE, McLaughlin AM, Keane J., Delayed Tuberculosis Paradoxical Reaction Associated with TNF Inhibitors., American journal of respiratory and critical care medicine, 2024
Jameson G, Walsh A, Woods R, Batten I, Murphy DM, Connolly SA, Duffin E, O'Gallchobhair O, Nadarajan P, O'Connell F, Gleeson LE, Keane J, Basdeo SA., Human tissue-resident NK cells in the lung have a higher glycolytic capacity than non-tissue-resident NK cells in the lung and blood., Proceedings of the National Academy of Sciences of the United States of America, 121, (42), 2024, pe2412489121
Leisching G, Yennemadi A, Gogan K, Keane J., Interferon " and ß induce differential transcriptional and functional metabolic phenotypes in human macrophages and blunt glycolysis in response to antigenic stimuli., European journal of immunology, 2024, pe2451032
Keane B, Hayes C, Roycroft E, Fitzgibbon M, O Beirne S, Lyng P, Dolan L, McLaughlin AM, Keane J., Zoonotic tuberculosis and pathogen whole genome sequencing., Irish medical journal, 117, (2), 2024, p922
Auld SC, Sheshadri A, Alexander-Brett J, Aschner Y, Barczak AK, Basil MC, Cohen KA, Dela Cruz C, McGroder C, Restrepo MI, Ridge KM, Schnapp LM, Traber K, Wunderink RG, Zhang D, Ziady A, Attia EF, Carter J, Chalmers JD, Crothers K, Feldman C, Jones BE, Kaminski N, Keane J, Lewinsohn D, Metersky M, Mizgerd JP, Morris A, Ramirez J, Samarasinghe AE, Staitieh BS, Stek C, Sun J, Evans SE., Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report., Annals of the American Thoracic Society, 21, (9), 2024, p1219-1237
Murphy DM, Walsh A, Stein L, Petrasca A, Cox DJ, Brown K, Duffin E, Jameson G, Connolly SA, O'Connell F, O'Sullivan J, Basdeo SA, Keane J, Phelan JJ., Human Macrophages Activate Bystander Neutrophils' Metabolism and Effector Functions When Challenged with Mycobacterium tuberculosis., International journal of molecular sciences, 25, (5), 2024, p2898
Yennemadi AS, Jameson G, Glass M, De Pasquale C, Keane J, Bianchi M, Leisching G., Chronic IFN" treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring., Cellular immunology, 390, 2023, p104741
Cheng GS, Crothers K, Aliberti S, Bergeron A, Boeckh M, Chien JW, Cilloniz C, Cohen K, Dean N, Dela Cruz CS, Dickson RP, Greninger AL, Hage CA, Hohl TM, Holland SM, Jones BE, Keane J, Metersky M, Miller R, Puel A, Ramirez J, Restrepo MI, Sheshadri A, Staitieh B, Tarrand J, Winthrop KL, Wunderink RG, Evans SE., Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report., Annals of the American Thoracic Society, 20, (3), 2023, p341-353
Ottewill C, Dolan L, Bailén EL, Roycroft E, Fitzgibbon M, Donohue EO, McLaughlin AM, McGrath G, Keane J., Immunosuppressed Pets as a Conduit for Zoonotic Tuberculosis., American journal of respiratory and critical care medicine, 208, (6), 2023, p732-733
Murphy, D.M., Cox, D.J., Connolly, S.A., Breen, E.P., Brugman, A.A.I., Phelan, J.J., Keane, J., Basdeo, S.A., Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine, Journal of Clinical Investigation, 133, (2), 2023
Anjali S. Yennemadi, Joseph Keane, Gina Leisching, Mitochondrial bioenergetic changes in systemic lupus erythematosus immune cell subsets: Contributions to pathogenesis and clinical applications, Lupus, 2023, p096120332311646
Bedard M, van der Niet S, Bernard EM, Babunovic GH, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB., A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages., The Journal of clinical investigation, 2023, pe161944
Triglia D, Gogan KM, Keane J, O'Sullivan MP., Glucose metabolism and its role in the maturation and migration of human CD1c+ dendritic cells following exposure to BCG., Frontiers in cellular and infection microbiology, 13, 2023, p1113744
Drakeford, C. and Aguila, S. and Roche, F. and Hokamp, K. and Fazavana, J. and Cervantes, M.P. and Curtis, A.M. and Hawerkamp, H.C. and Dhami, S.P.S. and Charles-Messance, H. and Hackett, E.E. and Chion, A. and Ward, S. and Ahmad, A. and Schoen, I. and Breen, E. and Keane, J. and Murphy, R. and Preston, R.J.S. and Oâ Sullivan, J.M. and Sheedy, F.J. and Fallon, P. and Oâ Donnell, J.S., von Willebrand factor links primary hemostasis to innate immunity, Nature Communications, 13, (1), 2022
Mansfield M, McLaughlin AM, Roycroft E, Montgomery L, Keane J, Fitzgibbon MM, Rogers TR., Diagnostic Performance of Xpert MTB/RIF Ultra Compared with Predecessor Test, Xpert MTB/RIF, in a Low TB Incidence Setting: a Retrospective Service Evaluation., Microbiology spectrum, 10, (3), 2022, pe0234521
Gaffney E, Murphy D, Walsh A, Connolly S, Basdeo SA, Keane J, Phelan JJ, Defining the role of neutrophils in the lung during infection: Implications for tuberculosis disease., Frontiers in immunology, 2022
Bahlool AZ, Fattah S, O'Sullivan A, Cavanagh B, MacLoughlin R, Keane J, O'Sullivan MP, Cryan SA., Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis., Pharmaceutics, 14, (8), 2022, p1745
Bahlool AZ, Grant C, Cryan SA, Keane J, O'Sullivan MP., All trans retinoic acid as a host-directed immunotherapy for tuberculosis., Curr Res Immunol, 3, 2022, p54-72
Jarsberg LG, Kedia K, Wendler J, Wright AT, Piehowski PD, Gritsenko MA, Shi T, Lewinsohn DM, Sigal GB, Weiner MH, Smith RD, Keane J, Jacobs JM, Nahid P., Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region., PloS one, 16, (5), 2021, pe0250586
Ó Maoldomhnaigh C, Cox DJ, Phelan JJ, Malone FD, Keane J, Basdeo SA., The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages., Frontiers in immunology, 12, 2021, p657261
Phelan JJ, O'Leary S, Keane J., Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy., The Journal of clinical investigation, 131, (15), 2021
Fitzgibbon MM, Roycroft E, Sheehan G, Mc Laughlin AM, Quintyne KI, Brabazon E, O'Meara M, Flanagan PR, Seagar AL, Laurenson IF, Keane J, Rogers TR., False detection of rifampicin resistance using Xpert® MTB/RIF Ultra assay due to an A451V mutation in Mycobacterium tuberculosis., JAC Antimicrob Resist, 3, (3), 2021, pdlab101
Cahill C, O'Connell F, Gogan KM, Cox DJ, Basdeo SA, O'Sullivan J, Gordon SV, Keane J, Phelan JJ., The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG., International journal of molecular sciences, 22, (6), 2021
Fennelly M, Keane J, Dolan L, Plant BJ, O'Connor D, Sodeau J, Prentice MB., Containment of Procedure-Associated Aerosols by an Extractor Tent: effect on nebulised drug particle dispersal., The Journal of hospital infection, 2021
Cilian Ó Maoldomhnaigh, Donal J Cox, James Joseph Phelan, Karl M. Gogan, Kate McQuaid, Amy Martina Coleman, Sharee Ann Basdeo and Joseph Keane., Lactate alters metabolism in human macrophages and improves their ability to kill Mycobacterium tuberculosis, Frontiers in Immunology, 2021
O'Leary S, Bahlool AZ, O'Connor G, Cryan SA, Keane JM, O'Sullivan MP., An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis., Journal of visualized experiments : JoVE, (174), 2021
Christina Cahill, Dónal J. Cox, Fiona O'Connell, Sharee A. Basdeo, Karl M. Gogan, Cilian Ó'Maoldomhnaigh, Jacintha O'Sullivan, Joseph Keane and James J. Phelan., The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis, International Journal of Molecular Sciences, 2021
Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4
Cox, D.J., Coleman, A.M., Gogan, K.M., Phelan, J.J., Maoldomhnaigh, C., Dunne, P.J., Basdeo, S.A. and Keane, J., Inhibiting histone deacetylases in human macrophages promotes glycolysis, IL-1β and T helper cell responses to Mycobacterium tuberculosis, Frontiers in Immunology, 2020
Cahill, C.*, Phelan, J.J.* and Keane, J, Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics, Frontiers in Cellular and Infection Microbiology, 2020
Leisching G, Keane J., Bystander Macrophage Metabolic Shift after Mycobacterium tuberculosis Infection., American journal of respiratory cell and molecular biology, 63, (6), 2020, p863-865
Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020
Waqas S, Dunne K, Talento AF, Wilson G, Martin-Loeches I, Keane J, Rogers TR., Prospective observational study of respiratory Aspergillus colonization or disease in patients with various stages of chronic obstructive pulmonary disease utilizing culture versus nonculture techniques., Medical mycology, 2020
O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European Journal of Pharmaceutics and Biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165
Gleeson LE, O'Leary SM, Ryan D, McLaughlin AM, Sheedy FJ, Keane JM., Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium Tuberculosis Infection., American journal of respiratory cell and molecular biology, 2018
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR., Molecular epidemiology of multi- and extensively-drug-resistant mycobacterium tuberculosis in ireland, 2001-2014., The Journal of infection, 76, (1), 2018, p55-67
Schwander, S. and Keane, J., Cause or effect? the elusive role of regulatory t cells in tuberculosis, American Journal of Respiratory and Critical Care Medicine, 198, (1), 2018, p11-12
Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156-
Coleman MM, Basdeo SA, Coleman AM, Cheallaigh CN, Peral de Castro C, McLaughlin AM, Dunne PJ, Harris J, Keane J., All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection., American journal of respiratory cell and molecular biology, 59, (5), 2018, p548-556
Phelan JJ, Basdeo SA, Tazoll SC, McGivern S, Saborido JR and Keane J, Modulating Iron for Metabolic Support of TB Host Defense, Frontiers in Immunology, 2018
Chong SG, McLaughlin AM, Keane J., Response: Disseminated tuberculosis., QJM : monthly journal of the Association of Physicians, 110, (5), 2017, p333
Cambier CJ, O'Leary SM, O'Sullivan MP, Keane J, Ramakrishnan L., Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages., Immunity, 47, (3), 2017, p552 - 565
Chong Sy Giin, Herron Malcolm, Dorman Anthony, Little Mark, Donnelly Seamas C, Keane Joseph, McLaughlin Anne Marie, Renal amyloidosis complicating multidrug-resistant tuberculosis , The International Journal of Tuberculosis and Lung Disease , 21 , (4 ), 2017, p476 - 477
Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379
Chong SG, Herron M, Dolan L, McDonald C, O'Donnell R, Fahy RJ, Keane J, McLaughlin AM, TB osteomyelitis , QJM , 2016, phcw166 -
Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885
Buckley A, McDonnell C, Keane J, McLaughlin AM, First Case of Multidrug Resistant Spinal TB in Ireland. , Irish medical journal , 109 , (9 ), 2016, p473 -
Judge E., Ahmed M., Fitzgibbon M., McLaughlin A., Keane J., Mycobacterium avium complex pulmonary disease: Characteristics and treatment in an Irish patient cohort, Irish Medical Journal, 109, (4), 2016, p398
Branagan P, Moran B, Fitzgibbon M, Reid V, McMenamin M, Kane M, Kelly F, Barnes L, McLaughlin A, Keane J, Inoculation site leprosy in a tattoo as a paradoxical reaction following tuberculosis treatment., The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 20, (5), 2016, p706-8
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449
Lewinsohn David M, Leonard Michael K, LoBue Philip A, Cohn David L, Daley Charles L, Desmond Ed, Keane Joseph, Lewinsohn Deborah A, Loeffler Ann M, Mazurek Gerald H, Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children , Clinical Infectious Diseases , 2016, pciw694 -
O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J, Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery., Advanced Drug Delivery Reviews, 102, 2016, p33 - 54
Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP, Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF"B and Autophagy Dependent Bacillary Killing., PloS one, 11, (2), 2016, pe0149167
O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J, Cigarette Smoking Impairs Human Pulmonary Immunity to Mycobacterium tuberculosis., American journal of respiratory and critical care medicine, 190, (12), 2015, p1430-1436
Gleeson, L.E., Varghese, C., Ryan, E., Kane, M., Mcdonald, C., Gleeson, N., McLaughlin, A.-M., Butler, K., Gavin, P., Keane, J., Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis, QJM, 108, (11), 2015, p899-901
Gleeson LE, Varghese C, Ryan E, Kane M, McDonald C, Gleeson N, McLaughlin AM, Butler K, Gavin P, Keane J, Untreated Chronic Tuberculous Salpingitis followed by successful IVF Conception and Congenital Tuberculosis., QJM : monthly journal of the Association of Physicians, 2015
Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347
Dunne, P.J., Richard, G., Keane, J., Commercially available, FDA-approved epigenetic modifiers as therapeutic agents in bacterial infection, Clinical Anti-Inflammatory and Anti-Allergy Drugs, 2, (1), 2015, p79-88
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80
Gleeson LE, Keane J, First Steps in Biomarker Assessment for Reactivation Risk in Latent Tuberculosis Infection., American journal of respiratory and critical care medicine, 192, (5), 2015, p534-5
Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A, A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer., The New England journal of medicine, 373, (3), 2015, p243-51
Lyons J, Vandenberghe E, Fahy R, McDonnell C, Keane J, McLaughlin AM, An unusual lung mass post stem cell transplantation., Transplant infectious disease : an official journal of the Transplantation Society, 16, (4), 2014, p672-675
Hoefsloot W, van Ingen J, Andrejak C, Angeby K, Bauriaud R, Bemer P, Beylis N, Boeree MJ, Cacho J, Chihota V, Chimara E, Churchyard G, Cias R, Dasa R, Daley CL, Dekhuijzen PN, Domingo D, Drobniewski F, Esteban J, Fauville-Dufaux M, Folkvardsen DB, Gibbons N, Gómez-Mampaso E, Gonzalez R, Hoffmann H, Hsueh PR, Indra A, Jagielski T, Jamieson F, Jankovic M, Jong E, Keane J, ... Winthrop K, Wagner D, The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 42, (6), 2013, p1604-1613
Kane M, Korn B, Saukkonen J, McDonald C, Walsh C, Waters R, McLaughlin AM, Keane J, Barriers to accepting and completing latent tuberculosis infection treatment., Irish medical journal, 106, (7), 2013, p200-4
Ní Cheallaigh C, Fitzgerald I, Grace J, Jagjit Singh G, El-Eraki N, Gibbons N, Keane J, Rogers TR, Clarke S, Bergin C, Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country., PloS one, 8, (1), 2013, pe53330
Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80
Doherty AM, Kelly J, McDonald C, O'Dywer AM, Keane J, Cooney J, A review of the interplay between tuberculosis and mental health., General hospital psychiatry, 35, (4), 2013, p398-406
Coleman, M.M., Finlay, C.M., Moran, B., Keane, J., Dunne, P.J., Mills, K.H., The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis, FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413-424
Coleman, M.M., Finlay, C.M., Moran, B., Keane, J., Dunne, P.J., Mills, K.H., The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis, FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413-424
McLaughlin AM, Gibbons N, Fitzgibbon M, Power JT, Foley SC, Hayes JP, Rogers T, Keane J, Primary Isoniazid Resistance in Mycobacterium bovis Disease: A Prospect of Concern., American Journal of Respiratory and Critical Care Medicine, 186, (1), 2012, p110-1
Lawlor C, O'Sullivan MP, Rice B, Dillon P, Gallagher PJ, O'Leary S, Shoyele S, Keane J, Cryan SA, Therapeutic aerosol bioengineering of targeted, inhalable microparticle formulations to treat Mycobacterium tuberculosis (MTb)., Journal of Materials Science. Materials in Medicine, 23, (1), 2012, p89 - 98
Macdonald SH, Woodward E, Coleman MM, Dorris ER, Nadarajan P, Chew WM, McLaughlin AM, Keane J, Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis., PloS one, 7, (6), 2012, pe38488
Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424
Lawlor C, Kelly C, O'Leary S, O'Sullivan M, Gallagher PJ, Keane J Cryan SA, Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of tuberculosis, Tuberculosis, 91, (1), 2011, p93 - 97
Ní Cheallaigh C, Keane J, Lavelle EC, Hope JC, Harris J., Autophagy in the immune response to tuberculosis: clinical perspectives., Clinical and Experimental Immunology, 164, (3), 2011, p291 - 300
Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs, Roswita Streich, Caroline Breysach, Dirk Raddatz, Septimia Oniga, Teresa Peccerella, Peter Findeisen, Julia Kzhyshkowska, Alexei Gratchev, Stefan Schweyer, Bernadette Saunders, Johannes T. Wessels, Wiebke Möbius, Joseph Keane, Heinz Becker, Arnold Ganser, Michael Neumaier, Wolfgang E. Kaminski, A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis, PLoS Pathogens, 7, (11, e1002375), 2011
Kennedy B, Connor B, Korn B, Gibbons N, O'Connor T, Keane J, Multi-drug resistant tuberculosis: experiences of two tertiary referral centres., Irish medical journal, 104, (6), 2011, p182-5
Lawlor, C., O'Sullivan, M.P., Sivadas, N., O'Leary, S., Gallagher, P.J., Keane, J., Cryan, S.-A., The application of high-content analysis in the study of targeted particulate delivery systems for intracellular drug delivery to alveolar macrophages, Molecular Pharmaceutics, 8, (4), 2011, p1100-1112
Cryan, S.-A., Hibbitts, A., Yadav, A., Kelly, C., Jefferies, C., Greene, C., McElvaney, N.G., O'sullivan, M., Keane, J., Lawlor, C., Barlow, J., Therapeutic aerosol bioengineering for targeted delivery in the lungs, 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011
Hassan TM, Keane J, McLaughlin AM., Paradoxical reaction causing tuberculous arthritis and soft-tissue abscess in a non-HIV infected, lymphopenic, vitamin D deficient patient with disseminated tuberculosis. A coincidence or an immunological conundrum?, Joint Bone Spine, 78, (3), 2011, p322 - 323
Hassan, T.M., Keane, J., McLaughlin, A.M., Paradoxical response involving tuberculous arthritis with soft tissue abscess in a female patient with disseminated tuberculosis, non-HIV infection, lymphopenia and vitamin D deficiency. Coincidence or immunological enigma? | Réaction paradoxale entraînant une arthrite tuberculeuse avec abcès des parties molles chez une patiente atteinte d'une tuberculose disséminée, non infectée par le VIH, lymphopénique et carencée en vitamine D. Coïncidence ou énigme immunologique?, Revue du Rhumatisme (Edition Francaise), 78, (2), 2011, p197-198
Lawlor C, Kelly C, O'Leary S, O'Sullivan MP, Gallagher PJ, Keane J, Cryan SA., Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of MTb., Tuberculosis, 91, (1), 2011, p93 - 97
S O'Leary, M O'Sullivan, J Keane, IL-10 blocks phagosome maturation in Mycobacterium tuberculosis-infected human macrophages, American Journal of Respiratory Cell and Molecular Biology, 45, (1), 2011, p172 - 180
Kiely B, McLaughlin AM, Lynch TH, Keane J., Intravesical bacille Calmette-Guérin-induced multiorgan failure after treatment for transitional cell carcinoma., Scand J Urol Nephrol, 45, (4), 2011, p278 - 280
Anandaiah A, Dheda K, Keane J, Koziel H, Moore DA, Patel NR, Novel Developments in the Epidemic of HIV and TB Co-Infection., Am J Respir Crit Care Med, 183, (8), 2011, p987 - 997
T Hassan, AM McLaughlin, F O'Connell, N Gibbons, S Nicholson, J Keane, EBUS-TBNA performs well in the diagnosis of isolated thoracic tuberculous lymphadenopathy, American Journal of Respiratory and Critical Care Medicine , 183, (1), 2011, p136 - 137
Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA., The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages., Mol Pharm, 8, (4), 2011, p1100 - 1112
Anandaiah, A., Dheda, K., Keane, J., Koziel, H., Moore, D.A.J., Patel, N.R., Novel developments in the epidemic of human immunodeficiency virus and tuberculosis coinfection, American Journal of Respiratory and Critical Care Medicine, 183, (8), 2011, p987-997
Ryan RC, O'Sullivan MP, Keane J, Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells., BMC Microbiology, 11, 2011, p237-
Cahill KC, Conroy FJ, Brown A, Dunlop RL, Eadie P, Keane J, Tuberculous dactylitis in the setting of low serum vitamin D - A case report., J Plast Reconstr Aesthet Surg, 64, (12), 2011, p321 - 324
Siddiqui UA, O'Toole M, Kabir Z, Qureshi S, Gibbons N, Kane M, Keane J, Smoking prolongs the infectivity of patients with tuberculosis., Irish medical journal, 103, (9), 2010, p278-80
Coleman, M.M., Keane, J., Mills, K.H.G., Editorial: Tregs and BCG - Dangerous liaisons in TB, Journal of Leukocyte Biology, 88, (6), 2010, p1067-1069
Chan, E.D. Keane, J., Iseman, M.D, Should cigarette smoke exposure be a criterion to treat latent tuberculous infection?, American Journal of Respiratory and Critical Care Medicine, 182, 2010, p990 - 992
Coleman MM, Keane J, Mills KH., Tregs and BCG--dangerous liaisons in TB., Journal of Leukocyte Biology, 88, (6), 2010, p1067 - 1069
Martin J, Walsh C, Gibbs A, McDonnell T, Fearon U, Keane J, Codd MB, Dodd JD, Veale D, Fitzgerald O, Bresnihan B., Comparison of interferon-gamma-release assays and conventional screening tests before tumour necrosis factor-alfa blockade in patients with inflammatory arthritis, Annals of Rheumatological Diseases, 69, (1), 2010, p181 - 185
Harris J, Keane J, How TNF Blockers Interfere with TB Immunity, Clinical and Experimental Immunology , 161, (1), 2010, p1 - 9
James Harris, Joseph Keane, How tumour necrosis factor blockers interfere with tuberculosis immunity., Clinical and Experimental Immunology, 161, (1), 2010, p1 - 9
Lee C.L., Doran, M, Keane J., Tuberculosis associated with tumor necrosis factor blocker therapy despite following guidelines, 2009
Harris, J., Master, S.S., De Haro, S.A., Delgado, M., Roberts, E.A., Hope, J.C., Keane, J., Deretic, V. , Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages, Veterinary Immunology and Immunopathology , 128, (1-3), 2009, p37-43
Keane, Joseph, Regulatory Role of CD4+, 2009, -
Harris, J., Hope, J. C., Keane, J., Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis, Journal of Infectious Diseases, 198, (12), 2008, p1842 - 1850
Meade KG, Gormley E, O'Farrelly C, Park SD, Costello E, Keane J, Zhao Y, Machugh DE., Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC Genomics, 29, (9), 2008, p447-
Keane, J and Bresnihan, B, Tuberculosis reactivation during immunosuppressive therapy in rheumatic diseases: Diagnostic and therapeutic strategies, Current Opinions in Rheumatology , 20, (4), 2008, p443 - 449
Kelly, D. ten Bokum, AM.C., O'Leary, S., O'Sullivan, M., Keane, J., Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection, Infection and Immunity , Jan;76, (1), 2008, p351 - 360
Kelly, DM, ten Bokum, AM, O'Leary, SM, O'Sullivan, MP, Keane, J, Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection., Infection and Immunity, 76, (1), 2008, p351 - 360
Harris, J., Hope, JC. and Keane, J., Tumor-necrosis factor blockers influence macrophage responses to M. tuberculosis, The Journal of Infectious Diseases , 198, (12), 2008, p1842-1850
Kennedy B, Lyons O, McLoughlin AM, Gibbons N, O'Flanagan D, Keane J., Extensively drug-resistant tuberculosis: first report of a case in Ireland., EUROSURVEILLANCE, 13, (30), 2008, ppii=18935
McLaughlin AM, Donnell RA, Nicolson S, Keane J, Young VK, A pulmonary mass with invasion into the heart., International Seminars in Surgical Oncology, 5, (1), 2008, particle no 24
Bothamley GH, Ditiu L, Migliori GB, Lange C; TBNET contributors., Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey., European Respiratory Journal, 32, (4), 2008, p1023-1030
Molloy D, Sayana MK, Keane J, Mehigan B., Anal fistula: an unusual presentation of tuberculosis in a migrant health care professional., Irish Journal of Medical Science, 2008, p1-3
Sopp P, Coad M, Hewinson G, Howard CJ, Cheallaigh CN, Keane J, Harris J, Hope JC., Development of a simple, sensitive, rapid test which discriminates BCG vaccinated from Mycobacterium bovis-infected cattle, Vaccine, 26, (43), 2008, p5470-5476
Keane J, Ní Cheallaigh C., Making tumor necrosis factor blockers safer: a prescriber's consumptive challenge, Journal of Rheumatology, 35, (7), 2008, p1238 - 1239
McLaughlin A, Keane J, Donnell RA, Dysphagia caused by lymphadenopathy - what is the differential diagnosis?, The Clinical Respiratory Journal , Dec; 1, (2), 2007, p122 - 124
O'Sullivan, MP, O'Leary, S, Kelly, DM, Keane, J, A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection., Infection and Immunity, 75, (4), 2007, p1984 - 1993
McLaughlin, A.M., McMahon, C.J., Fitzpatrick, A., Keane, J., O'Donnell, R.A., Educational case: dysphagia caused by lymphadenopathy--what is the differential diagnosis?, The clinical respiratory journal, 1, (2), 2007, p122-124
O'Sullivan, M., Kelly, D., O'Leary, S., Keane, J., Macrophage cell death in response to M.tuberculosis infection is mediated by a caspase-independent pathway, Infection and Immunity, 75, (4), 2007, p1984 - 1993
A. Spira, J. Beane V. Shah G. Liu, K Steiling, F Schembri S Gilman, M Dumas, P Sebastiani Sriram Sridhar, X Yang, P Calner, J Beamis, J Keane, M Lenburg, JS Brody, Airway Epithelial Gene Expression in the Diagnostic Evaluation of Smokers with Suspect Lung Cancer, Nature Medicine, Mar; 13, (3), 2007, p361 - 366
Harris, J., De Haro, S.A., Master, S.S., Keane, J., Roberts, E.A., Delgado, M., Deretic, V., T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis (DOI:10.1016/j.immuni.2007.07.022), Immunity, 27, (4), 2007
Meade KG, Gormley E, Doyle MB, Fitzsimons T, O' Farrelly C, Costello E, Keane J, Zhao Y, MacHugh DE, Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease, BMC Genomics, Oct 31; 8, (1: 400), 2007
McLaughlin A, Meaney JF, Keane J, Donnell RA, Left atrial invasion by pulmonary adenocarcinoma, Eur J Cardiothorac Surg., Mar 9, 2007, p936
Harris, J., De Haro, SA., Master,SS., Keane J, Roberts EA, Delgado, M and Deretic V, T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis, Immunity , Sep;27, (3), 2007, p505 - 517
Meade KG, Gormley E, Park SD, Fitzsimons T, Rosa GJ, Costello E, Keane J, Coussens PM, Machugh DE., Gene expression profiling of peripheral blood mononuclear cells (PBMC) from Mycobacterium bovis infected cattle after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD)., Veterinary Immunology and Immunopathology , 113, (1-2), 2006, p73-89
Ali S, Chew N, Manning P, Noonan N, Keane J and Bergin C. , The prevalence of Latent Pulmonary Tuberculosis (LTBI) in a Normal and High Risk Population Group. , 2005, - 397S-a
Keane, J., TNF-blocking agents and tuberculosis: New drugs illuminate an old topic, Rheumatology, 44, (6), 2005, p714-720
Keane, J., TNF blocking agents and tuberculosis: new drugs illuminate an old topic, Rheumatology, Jun; 44, (6), 2005, p714 - 720
A. Bella, A.M.C. ten Bokum, N. Noonan, J. Rothel, P Kelly ,J. Keane , The Evaluation of the QuantiFERON TB test for the Diagnosis of Tuberculosis Disease and Latent Tuberculosis Infection (LTBI) in the Irish Population: Preliminary Results, Irish Journal of Medical Science , 173, (1), 2004, p33-
Programmed cell death in tuberculosis in, editor(s)William N. Rom and Stuart M.Garay, with foreword by Barry R. Bloom. , Tuberculosis , Philadelphia , Lippincott Williams & Wilkins, 2004, [Joseph Keane and Hardy Kornfeld ]
Keane, J., Tumor Necrosis Factor Blockers and Reactivation of Latent Tuberculosis, Clinical Infectious Disease, 39, (3), 2004, p300 - 302
Tuberculosis and apoptosis in, editor(s)William N. Rom and Stuart M.Garay , Tuberculosis, Philadelphia , Lippincott Williams & Wilkins, 2004, [J Keane]
A.M.C. ten Bokum, M. O'Sullivan, J. Keane, Apoptosis of uninfected "bystander" macrophages in the presence of macrophages infected with Mycobacterium tuberculosis, Irish Journal of Medical Science , 173, (1), 2004, p56-
A. Bella, A.M.C. ten Bokum, N. Noonan, J. Rothel, P Kelly ,J. Keane , The Evaluation of the QuantiFERON TB test for the Diagnosis of Tuberculosis Disease and Latent Tuberculosis Infection (LTBI) in the Irish Population: Preliminary Results, 2004, - 33
Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld K, Keane J, Apoptosis Genes in Human Alveolar Macrophages Infected with Virulent or Attenuated M. tuberculosis; A pivotal role for TNF, American Journal of Respiratory Cell and Molecular Biology, November; 29, (5), 2003, p545 - 551
Berk J, Keane J, Seldin DC, Sanchorawala V, Koyama J, Dember L, Falk R, Persistent pleural effusions in primary systemic amyloidosis: etiology and prognosis, Chest, 124, (3), 2003, p969 - 977
Spira, A., Carroll, J.D., Liu, G., Aziz, Z., Shah, V., Kornfeld, H., Keane, J., Apoptosis Genes in Human Alveolar Macrophages Infected with Virulent or Attenuated Mycobacterium tuberculosis: A Pivotal Role for Tumor Necrosis Factor, American Journal of Respiratory Cell and Molecular Biology, 29, (5), 2003, p545-551
J J Saukkonen, B Bazydlo, M Thomas, RM. Strieter, J Keane, H Kornfeld, ß-Chemokines Are Induced by Mycobacterium tuberculosis and Inhibit Its Growth, Infection and Immunity, Apr; 70, (4), 2002, p1684 - 1693
Reid, V.A., Keane, J. , Images in clinical medicine. Tuberculous mastoiditis and cerebral tuberculoma. , The New England Journal of Medicine, 347, (23-24), 2002, pe6
Saukkonen, J.J., Bazydlo, B., Thomas, M., Strieter, R.M., Keane, J., Kornfeld, H., ß-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth, Infection and Immunity, 70, (4), 2002, p1684-1693
Reid V and Keane J, Tuberculosis Mastoiditis and Cerebral Tuberculoma, New England Journal of Medicine, 347, (e6), 2002
Lim, W.S., Powell, R.J., Johnston, I.D., Zhang, Z., Correa, H., Bégué, R.E., De Rosa, F.G., Bonora, S., Di Perri, G., Myers, A., Clark, J., Foster, H., Riminton, S., Pearce, N., Basten, A., Keane, J., Gershon, S.K., Braun, M.M., Tuberculosis and treatment with infliximab [2] (multiple letters), New England Journal of Medicine, 346, (8), 2002, p623-626
Keane J, Shurtleff B, Kornfeld H, TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-g independent manner, Tuberculosis, 82, (2-3), 2002, p55-61
Lucey EC, Keane J, Kuang PP, Snider GL, Goldstein RH, Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1ß receptor-deficient mice, Laboratory Investigation, Jan; 82, (1), 2002, p79 - 85
Keane J., Gershon S.K., Braun M.M., Tuberculosis and Treatment with Infliximab, New England Journal of Medicine, 346, (8), 2002, p623 - 626
Keane, J., Gershon, S., Wise, R.P., Mirabile-Levens, E., Kasznica, J., Schwieterman, W.D., Siegel, J.N., Braun, M.M., Tuberculosis associated with infliximab, a tumor necrosis factor "-neutralizing agent, New England Journal of Medicine, 345, (15), 2001, p1098-1104
Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel, JN, Braun MM , Tuberculosis Associated With Infliximab, a TNF a-Neutralizing Agent, New England Journal of Medicine , 345, (15), 2001, p1098 - 1104
Akalin E, Chandrakantan A, Keane J, Hamburger RJ, Normouricemia in the Syndrome of Inappropriate Antidiuretic Hormone Secretion., American Journal of Kidney Diseases, 37, (1), 2001, pE8
Means TK, Jones BW, Schromm AB, Shurtleff BA, Smith JA, Keane J, Golenbock DT, Vogel SN, Fenton MJ, Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses , Journal of Immunology, 166, (6), 2001, p4074-4082
Carroll JD, Wallace RC, Keane J, Remold HG, Arbeit RD , Identification of Mycobacterium avium DNA sequences that encode exported proteins by using phoA gene fusions. , Tubercle and Lung Disease, 80, (3), 2000, p117-130
Keane J, Remold H, Kornfeld H, Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages, Journal of Immunology, 164, (4), 2000, p2016-2020
Fratazzi C, Arbeit RD, Carini C, B-Sablinska MK, Keane J, et al., Macrophage apoptosis in mycobacterial infections, Journal of Leukocyte Biology, 66, (5), 1999, p763-764
Keane, J., Gochuico, B., Kasznica, J.M., Kornfeld, H., Usual interstitial pneumonitis responsive to corticosteroids following varicella pneumonia, Chest, 113, (1), 1998, p249-251
Sablinska M, Keane J, Remold HG, & Kornfeld H , Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha., Journal of Immunology, 161, (5), 1998, p2636-2641
Keane J, Gochuico B, Kasnica JM & Kornfeld H., (Cryptogenic fibrosing alveolitis) Usual Interstitial Pneumonitis Responsive to Corticosteroids following Varicella pneumonia , Chest, 113, (1), 1998, p249-251
Keane J, Cruikshank WW Center D & Kornfeld H et al., Conservation of Structure and Function between Human and Murine Interleukin-16, Journal of Immunology, 160, (12), 1998, p5945-5954
Keane J, Sablinska M, Remold HG, & Kornfeld H et al., Infection by Mycobacterium tuberculosis Promotes Human Alveolar Macrophage Apoptosis., Infection & Immunity, 65, (1), 1997, p298-304
Cruikshank WW, Kornfeld H, Berman J, Keane J, Center D., Biological activity of Interleukin-16, Nature, 381, (6589), 1996, p29-30
O'Conner C, Gaffney K Keane J, & FitzGerald MX et al., alpha1-Proteinase Inhibitor, Elastase activity, and Lung Disease Severity in Cystic Fibrosis, American Review of Respiratory Diseases, 148, 1993, p1665-1670
Keane J, Chan F, Over J & Finucane P., Respiratory Failure in the Elderly Hospitalized Patient , Journal of the Hong Kong Geriatric Society , 3, (1), 1992, p32-34
Keane J & Finucane P., "Whose bed is it anyway?" , Care of the Elderly, 1992, p158
Donal Cox and Joseph Keane, Platelets and Tuberculosis: Small Cells, Not So Innocent Bystanders, American Journal of Respiratory and Critical Care Medicine, 0, (ja), 0, pnull
Non-Peer-Reviewed Publications
Keane, Joseph, Tuberculosis Guidelines: National TB Advisory Committee, 2008
Keane, Joseph, American Thoracic Society - Programme committee, In:American Thoracic Society Conference, 2005
Keane, Joseph, Institute of Molecular Medicine: Programme committee , 2004 - present, 2004
Keane, Joseph, International Conference on Cytokine Medicine , 2004 - present, 2004
Keane, Joseph, TNF blockade and opportunistic infection -A position paper
Keane, Joseph, Diagnostic Standards & Classification of Tuberculosis in Adults and Children
Research Expertise
Description
THE HOST RESPONSE TO TUBERCULOSIS- The genetic basis of lung cancer: At St. James's we see 25% of the Irish lung cancer patients. My lab is collaborating with Boston University who are looking at the genetic profile of cells from these patients to address the questions 'Why do some smoker get lung cancer, and some smokers do not'. It is hope that this transcriptomics approach will allow for early detection for this disease that is almost always lethal because it presents late.
- The accurate staging of lung cancer using whole body MRI or PET
Recognition
Representations
Director: TB Immunology Lab, School of Medicine
Director: Clinical TB services, St. James's Supraregional Centre
Program Chair: American Thoracic Society, MTPI Assembly
Awards and Honours
Health Research Board: Clinical Scientist Award
Memberships
TBNET, STOP TB Partnership, International Union Against Tuberculosis and Lung Disease
Royal College of Physicians
American Thoracic Society
Irish Thoracic Society