Dr. Dania Movia
Adjunct Assistant Professor, Radiation Therapy
Biography
Dr. Dania Movia is a dynamic Assistant Professor in Biomedical & Health Services at the Department of Biology, Maynooth University. She also serves as Principal Investigator at the Kathleen Lonsdale Institute for Human Health Research, where her groundbreaking work continues to advance the respiratory research field. In addition, Dr Movia holds the position of Adjunct Assistant Professor at the Discipline of Radiation Therapy, Trinity College Dublin, Ireland, further solidifying her presence in the academic and research communities.
Dr Movia's academic journey began with a degree in Chemistry and Pharmaceutical Technologies, which she earned from the University of Trieste, Italy, in 2007. She went on to obtain her PhD from Trinity College Dublin in 2012. Trinity College later conferred upon her a Special Purpose Certificate in Academic Practice in 2018, and a Master of Arts (jure officii) in 2023 as a recognition of her ongoing contributions to the College.
A dedicated member of numerous esteemed professional organizations, Dr Movia plays a key role in shaping the future of cancer research and alternatives to animal testing. Her affiliations include the Irish Lung Cancer Alliance (ILCA), Cancer Trials Ireland, the European Association for Cancer Research (EACR), and the European Society for Alternatives to Animal Testing (EUSAAT), the European 3Rs Society that actively promotes the implementation of the 3Rs Principle (Reduce, Refine and Replace) in animal research. She also lends her expertise to the scientific advisory panels of Animal-Free Research UK and FRAME-UK and contributes to the COST Action CA21139 initiative - "3Rs Concepts to Improve the Quality of Biomedical Science (IMPROVE)."
With over 50 peer-reviewed publications to her name, Dr. Movia is a prolific contributor to scientific literature. In her editorial roles, she has served as Guest Editor for Animals (MDPI) and Frontiers in Bioengineering and Biotechnology, and she co-edited the book Cancer Cell Culture in the renowned Methods in Molecular Biology series published by Springer Nature. This work, featuring contributions from 38 international experts, stands as a testament to her collaborative spirit and leadership in the field. She currently serves as an Associate Editor for Frontiers in Pharmacology, continuing to influence and guide cutting-edge research.
Dr Movia's commitment to scientific excellence, her diverse roles, and her dedication to fostering innovation through sustainable animal-free research make her a leader in the biomedical field.
Publications and Further Research Outputs
Peer-Reviewed Publications
Ripoll-Viladomiu, I. and Prina-Mello, A. and Movia, D. and Marignol, L., Extracellular vesicles and the â six Rsâ in radiotherapy, Cancer Treatment Reviews, 129, (102799), 2024
Soliman, M.G. and Trinh, D.N. and Ravagli, C. and Meleady, P. and Henry, M. and Movia, D. and Doumett, S. and Cappiello, L. and Prina-Mello, A. and Baldi, G. and Monopoli, M.P., Development of a fast and simple method for the isolation of superparamagnetic iron oxide nanoparticles protein corona from protein-rich matrices, Journal of Colloid and Interface Science, 659, 2024, p503-519
Movia, D. and Prina-Mello, A., A Method for Culturing 3D Tumoroids of Lung Adenocarcinoma Cells at the Airâ"Liquid Interface, Methods in Molecular Biology, 2645, 2023, p173-178
Mullen, S. and Movia, D., The role of extracellular vesicles in non-small-cell lung cancer, the unknowns, and how new approach methodologies can support new knowledge generation in the field, European Journal of Pharmaceutical Sciences, 188, (106516), 2023
Galligioni, V. and Movia, D. and Ruiz-Perez, D. and Sanchez-Morgado, J.M. and Prina-Mello, A., The Case for Modernizing Biomedical Research in Ireland through the Creation of An Irish 3Rs Centre, Animals, 12, (9), 2022
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, St"pnik M, Soba"ska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H., The Rise of Three Rs Centres and Platforms in Europe., Alternatives to laboratory animals : ATLA, 50, (2), 2022, p90-120
Tutty, M.A. and Movia, D. and Prina-Mello, A., Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials, Drug Delivery and Translational Research, 2022
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Spielmann H, The Current Status and Work of Three Rs Centres and Platforms in Europe., Alternatives to laboratory animals : ATLA, 2022
Singh, B. and Abdelgawad, M.E. and Ali, Z. and Bailey, J. and Budyn, E. and Civita, P. and Clift, M.J.D. and Connelly, J.T. and Constant, S. and Hittinger, M. and Kandarova, H. and Kearns, V.R. and Kiuru, T. and Kostrzewski, T. and Kress, S. and Durban, V.M. and Lehr, C.-M. and McMillan, H. and Metz, J.K. and Monteban, V. and Movia, D. and Neto, C. and Owen, C. and Paasonen, L. and Palmer, K.A. and Pilkington, G.J. and Pilkington, K. and Prina-Mello, A. and Roper, C. and Sheard, J. and Smith, S. and Turner, J.E. and Roy, I. and Tutty, M.A. and Velliou, E. and Wilkinson, J.M., Towards more predictive, physiological and animal-free in vitro models: Advances in cell and tissue culture 2020 conference proceedings, ATLA Alternatives to Laboratory Animals, 49, (3), 2021, p93-110
Special Issue "Replacing Animal Testing in Research"A Scientific and Regulatory Perspective of Current Efforts Towards the 1R", Animals (MDPI), 2021-2022
Prina-Mello, A. and Bonacina, L. and Staedler, D. and Movia, D., Editorial: Use of 3D Models in Drug Development and Precision Medicine - Advances and Outlook, 1826, 2021, -
Dania Movia, Maroua Benhaddada, Jolanda Spadavecchia, Adriele Prina-Mello, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies , Precision Nanomedicine, 3, (2), 2020, p495 - 524
Special Issue "Use of 3D Models in Drug Development and Precision Medicine: Advances and Outlook", Frontiers in Bioengineering and Biotechnology, 2020-2021
Movia D, Prina-Mello A., Preclinical Development of Orally Inhaled Drugs (OIDs)-Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?, Animals : an open access journal from MDPI, 10, (8), 2020
Movia D, Bruni-Favier S, Prina-Mello A., In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective., Frontiers in bioengineering and biotechnology, 8, 2020, p549
Haddada MB, Movia D, Prina-Mello A, Spadavecchia J., Docetaxel gold complex nanoflowers: A chemo-biological evaluation for their use as nanotherapeutics., Colloids and surfaces. B, Biointerfaces, 194, 2020, p111172
Moustaoui H, Saber J, Djeddi I, Liu Q, Movia D, Prina-Mello A, Spadavecchia J, Lamy de la Chapelle M, Djaker N., A protein corona study by scattering correlation spectroscopy: a comparative study between spherical and urchin-shaped gold nanoparticles., Nanoscale, 11, (8), 2019, p3665-3673
Dania Movia, Despina Bazou, Adriele Prina-Mello, ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance, BMC Cancer, 19, (1), 2019
Adriele Prina-Mello and Dania Movia and Despina Bazou and Yuri Volkov and Adriele Prina-Mello, Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs, Scientific Reports, 2018, p12920-
Luisana Di Cristo, Sarah Mc Carthy, Keith Paton, Dania Movia, Adriele Prina-Mello, Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages, 2D Materials, 2018
Hutchinson D, Muller J, McCarthy JE, Gun'ko YK, Verma NK, Bi X, Di Cristo L, Kickham L, Movia D, Prina-Mello A, Volkov Y, Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease, International Journal of Chronic Obstructive Pulmonary Disease , 13, 2018, p441 - 449
Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids in, editor(s)Ferreira de Castro Gomes Andreia, Sárria Pereira Passos Marisa. , Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications, InTech, 2018, [Movia D., Prina-Mello A.]
Cristina Multari, Marta Miola, Sara Ferraris, Dania Movia, Kristina Žužek Rožman, Nina Kostevšek, Antonia Follenzi, Enrica Verné, Adriele Prina-Mello, Synthesis and characterization of silica-coated superparamagnetic iron oxide nanoparticles and interaction with pancreatic cancer cells, International Journal of Applied Ceramic Technology, 2018
Adriele Prina-Mello, Namrata Jain, Baiyun Liu, Jason I. Kilpatrick, Melissa A. Tutty, Alan P. Bell, Suzanne P Jarvis, Yuri Volkova, Dania Movia, Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D, Tissue and Cell, 50, 2018, p15 - 30
Di Cristo, L. and Maguire, C.M. and Mc Quillan, K. and Aleardi, M. and Volkov, Y. and Movia, D. and Prina-Mello, A., Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials, International Journal of Environmental Research and Public Health, 15, (4), 2018
Movia D., Di Cristo L., Alnemari R., McCarthy J. E., Moustaoui H., Lamy de la Chapelle M., Spadavecchia J., Volkov Y., Prina-Mello A., The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles, Journal of Interdisciplinary Nanomedicine, 2, (2), 2017, p110 - 130
Moore C., Movia D., Smith R., Hanlon D., Lebre F., Lavelle E., Byrne H., Coleman J., Volkov Y., McIntyre J., Industrial grade 2D molybdenum disulphide (MoS2): an in vitro exploration of the impact on cellular uptake, cytotoxicity, and inflammation, 2D Materials, 4, (2), 2017
Multilayered nanoparticles for personalized medicine: translation into clinical markets in, editor(s)Raj Bawa, Gerald F. Audette, Israel Rubinstein , Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications, Pan Stanford Publishing, 2016, pp299 - 318, [Dania Movia, Craig Poland, Lang Tran, Yuri Volkov, Adriele Prina-Mello]
Spadavecchia J, Movia D, Moore C, Maguire CM, Moustaoui H, Casale S, Volkov Y, Prina-Mello A, Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies., International journal of nanomedicine, 11, 2016, p791-822
Moustaoui H, Movia D, Dupont N, Bouchemal N, Casale S, Djaker N, Savarin P, Prina-Mello A, De La Chapelle M.L, Spadavecchia J, Tunable Design of Gold(III)-Doxorubicin Complex-PEGylated Nanocarrier. the Golden Doxorubicin for Oncological Applications, ACS Applied Materials and Interfaces, 8, (31), 2016, p19946 - 19957
Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, Janer G, Fuentes N, Vázquez-Campos S, Borges T, Silva MJ, Prina-Mello A, Movia D, Nesslany F, Ribeiro AR, Leite PE, Groenewold M, Cassee FR, Sips AJ, Dijkzeul A, van Teunenbroek T, Wijnhoven SW, Towards a nanospecific approach for risk assessment., Regulatory toxicology and pharmacology : RTP, 80, 2016, p46-59
Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E, Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences, 150, (1), 2016, p40-53
Bianca M Rotoli, Rita Gatti, Dania Movia, Massimiliano G Bianchi, Luisana Di Cristo, Ivana Fenoglio, Fabio Sonvico, Enrico Bergamaschi, Adriele Prina-Mello, Ovidio Bussolati, Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay, Nanotoxicology, 9, (2), 2015, p230-241
Mahfoud, O.K., Rakovich, T.Y., Prina-Mello, A., Movia, D., Alves, F., Volkov, Y., Detection of ErbB2: Nanotechnological solutions for clinical diagnostics, RSC Advances, 4, (7), 2014, p3422-3442
Catherine A Schütz, Davide Staedler, Kieran Crosbie-Staunton, Dania Movia, Catherine Chapuis Bernasconi, Blanka Halamoda Kenzaoui, Adriele Prina-Mello, Lucienne Juillerat-Jeannere, Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles, International Journal of Nanomedicine, 9, 2014, p3481 - 3498
Movia, D., Gerard, V., Maguire, C.M., Jain, N., Bell, A.P., Nicolosi, V., O'Neill, T., Scholz, D., Gun'ko, Y., Volkov, Y., Prina-Mello, A., A safe-by-design approach to the development of gold nanoboxes as carriers for internalization into cancer cells, Biomaterials, 35, (9), 2014, p2543-2557
Toxicity of carbon nanotubes in, Handbook of Green Chemistry - Green Processes (- Green Nanoscience), Germany, Wiley - VCH, 2013, pp175 - 216 , [Movia D. and Giordani S.]
Bashir Mustafa Mohamed, Dania Movia, Anton Knyazev, Dominique Langevin, Anthony Mitchell Davies, Adriele Prina-Mello, Yuri Volkov, Citrullination as early-stage indicator of cell response to Single-Walled Carbon Nanotubes, Scientific Reports, 3, (1124), 2013, p1 - 7
Singh, M., Movia, D., Mahfoud, O.K., Volkov, Y., Prina-Mello, A., Silver nanowires as prospective carriers for drug delivery in cancer treatment: An in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts, European Journal of Nanomedicine, 5, (4), 2013, p195-204
Del Canto E., Natali M., Movia D. and Giordani S., Photo-controlled Uptake and Release of Zinc Metal Ions by Spiropyran receptors anchored to Single-Walled Carbon Nanotubes, Phys. Chem. Chem. Phys. , 14, (17), 2012, p6034 - 6043
Anja Schinwald, Fiona A Murphy, Adriele Prina-Mello, Craig A Poland, Fiona Byrne, Dania Movia, James R Glass, Janet C Dickerson, David A Schultz, Chris E Jeffree, William Macnee, Ken Donaldson, The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma, Toxicological Sciences, 128, (2), 2012, p461 - 470
Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, p502386
Del Canto, E., Flavin, K., Movia, D., Navio, C., Bittencourt, C., Giordani, S., Critical investigation of defect site functionalization on single-walled carbon nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74
Del Canto E., Flavin K., Movia D., Navio C., Bittencourt C., Giordani S., A Critical Investigation of Defect Site Functionalization on Single Walled Carbon Nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74
Movia D, Prina-Mello A, Bazou D, Volkov Y, Giordani S, Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models., ACS Nano, 5, (11), 2011, p9278-9290
Del Canto E., Flavin K., Movia D., Giordani S., Oxidized Single-Walled Carbon Nanotubes: removal of carbonaceous functionalized material by washing with solvents or base, MRS Proceedings, 1362, 2011, pmrss11-1362-qq09-44
Movia, D., Prina-Mello, A. , Volkov, Y. , Giordani, S, Determination of spiropyran cytotoxicity by high content screening and analysis for safe application in bionanosensing, Chemical Research in Toxicology , 23, (9), 2010, p1459 - 1466
Movia D., Del Canto E., Giordani S., Purified and Oxidized Single Walled Carbon Nanotubes as Robust Near IR Fluorescent Probes for Molecular Imaging, Journal of Physical Chemistry C, 114, (43), 2010, p18407-18413
Preface in, editor(s)Raquel de Pedro Ricoy, Isabelle Perez and Christine Wilson , Interpreting and Translating in Public Service Settings Policy, Practice, Pedagogy, Manchester, St. Jerome, 2009, ppvii - viii, [Lorraine Leeson ]
Movia D., Del Canto E. and Giordani S., Spectroscopy of Single-Walled Carbon Nanotubes in Aqueous Surfactant Dispersion, physica status solidi (b), 246, (11-12), 2009, p2704 - 2707
Non-Peer-Reviewed Publications
Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016
Gavigan-Imedio J.D., Movia D., Volkov Y., Prina-Mello A., Nanomedicine translational oncology: a perspective to cancer treatment, EuroNanoForum, Dublin, Ireland, June 2013, 2013
Movia D., Del Canto E., Giordani S., Purified and Oxidized SWNTs: potential NIR fluorescence probes for molecular imaging, ChemOnTubes 2010, Arcachon, France, 11-15/04/2010, 2010
Research Expertise
Description
Dr Dania Movia is a passionate advocate for transforming biomedical research by reducing and replacing animal testing through sustainable research and the education of young scientists on new preclinical technologies. Her work is driven by a commitment to advancing science in a more sustainable direction, focusing on the development of New Approach Methodologies (NAMs) designed to replace animal studies in the fields of lung cancer and lung toxicity research. As the founder and lead of the Humane Biomedical Research Group, Dr Movia has established Ireland's first wet-lab dedicated entirely to animal-free respiratory research. The lab's groundbreaking mission is to accelerate the translation of preclinical data into effective clinical treatments for patients with respiratory diseases - without the use of animal experimentation. Through this pioneering initiative, Dr Movia aims to foster long-term therapeutic responses, ensuring that innovations in research directly benefit patient care. Her efforts have garnered international recognition and substantial financial support, with over €23 million in research funding, including more than €2 million allocated directly to her as Principal Investigator. This funding comes from a wide array of prestigious national, European, and international organizations, including the Irish Research Council, Science Foundation Ireland, the Johns Hopkins Center for Alternatives to Animal Testing, Animal-Free Research UK, and the European Commission. Dr Movia's leadership in humane science is not only advancing the field but is also shaping the future of biomedical research by setting a new standard for ethical, innovative, and sustainable approaches to disease treatment. Research areas: 1. In vitro New Approach Methodologies (NAMs) 2. Alternatives to animal research and 3Rs principle 3. Lung cancer research 4. Inhalation toxicology 5. Oncological nanomedicine 6. Risk assessment of nanomaterials 7. Nanotechnology An up-to-date list of her publications can be found at: https://scholar.google.com/citations?user=T60uEacAAAAJ&hl=en&oi=aoProjects
- Title
- Extracellular vesicles in Non-Small-Cell Lung Cancer - Finding allies among the enemies
- Funding Agency
- Science Foundation Ireland
- Date From
- 2022
- Date To
- 2026
- Title
- Developing novel inhaled bioengineered Extracellular Vesicle RNA based advanced therapeutics, delivered by tailored aerosol delivery technology for the treatment of lung cancer (INSPIRE)
- Funding Agency
- European Commission
- Date From
- 2022
- Date To
- 2025
- Title
- Towards a kinder yet impactful way to conduct lung cancer research
- Funding Agency
- School of Medicine, Trinity College Dublin
- Date From
- 2022
- Date To
- 2023
- Title
- Risk Management of Biomaterials (BIORIMA)
- Funding Agency
- European Union
- Date From
- 2017
- Date To
- 2022
- Title
- Pre-clinical models for predicting the toxicity, absorption and biodistribution of inhaled nanomaterials in humans
- Funding Agency
- Johns Hopkins University Center for Alternatives to Animal Testing (CAAT)
- Date From
- 2018
- Date To
- 2020
- Title
- Developing in vitro non-animal methods (NAMs) for mimicking human lung tumour complexity
- Funding Agency
- Enterprise Ireland
- Date From
- 2020
- Date To
- 2021
- Title
- Capturing human tumour complexity in 3D lung cancer models for predicting drugs' efficacy in patient
- Funding Agency
- Enterprise Ireland
- Date From
- 2018
- Date To
- 2018
- Title
- INEDITED - Improve NanomEDIcine Translation into clinical lung cancEr Drugs
- Funding Agency
- Irish Research Council
- Date From
- 2015
- Date To
- 2017
- Title
- Photochromic Network Polymers and Supramolecular Modification of Single-Walled Carbon Nanotubes
- Funding Agency
- Irish Research Council
- Date From
- 2008
- Date To
- 2012
Recognition
Representations
Scientific Advisory Panel member, FRAME UK
Scientific Advisory Panel member, Animal-Free Research UK.
Topic Editor for the Frontiers in Bioengineering and Biotechnology journal (Topic: Use of 3D Models in Drug Development and Precision Medicine: Advances and Outlook).
Review Editor, Predictive Toxicology, specialty section of the Frontiers in Pharmacology journal.
Reviewer for several international scientific journals. A list is available at: http://www.webofscience.com/wos/author/record/T-6552-2018
Guest Editor, Animals (MDPI) journal - Topic title: Replacing Animal Testing in Research"A Scientific and Regulatory Perspective of Current Efforts Towards the 1R.
Awards and Honours
Research Award in recognition for the publication of an internationally peer-reviewed publication of the highest quality.
Best Material Science Poster, 33rd Annual Microscopy Society of Ireland (MSI) meeting
Paper of the Year 2012, Society of Toxicology Board
Memberships
EACR (European Association for Cancer Research) membership
Irish Lung Cancer Alliance (ILCA) member
Cancer Trials Ireland membership