Dr. Nigel John Stevenson
Associate Professor, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Jeremiah, S.S. and Das, P. and Venkatesan, M. and Albinzayed, R. and Ahmed, A. and Stevenson, N.J. and Corbally, M. and Alqahtani, M. and Al-Wedaie, F. and Farid, E. and Hejres, S., Humoral and Innate Immunological Profile of Paediatric Recipients of Pfizer-BioNTech BNT162b2 mRNA Vaccine, Microorganisms, 12, (7), 2024
Efstathiou, C. and Zhang, Y. and Kandwal, S. and Fayne, D. and Molloy, E.J. and Stevenson, N.J., Respiratory syncytial virus NS1 inhibits anti-viral Interferon-α-induced JAK/STAT signaling, by limiting the nuclear translocation of STAT1, Frontiers in Immunology, 15, (1395809), 2024
Ashraf, M.A. and Mustafa, B.E. and Wahaab, A. and Batool, H. and Ashraf, M. and Said, M.B. and Sevinc, F. and Stevenson, N.J., Conventional and molecular diagnosis of parasites, 2023, 56-72pp
Herrera-Uribe J, Naylor P, Rajab E Coskuner G, Jassim MS Jassim, Al-Qahtani M & Stevenson NJ., Long term detection and quantification of SARS-CoV-2 RNA in wastewater in Bahrain., Journal of Hazardous Material Advances, 7, 2022, p1 - 9, p1-9
McKenna, E. and Wubben, R. and Isaza-Correa, J.M. and Melo, A.M. and Mhaonaigh, A.U. and Conlon, N. and Oâ Donnell, J.S. and NÃ Cheallaigh, C. and Hurley, T. and Stevenson, N.J. and Little, M.A. and Molloy, E.J., Neutrophils in COVID-19: Not Innocent Bystanders, Frontiers in Immunology, 13, (864387), 2022
Zhang, Y. and Gargan, S. and Roche, F.M. and Frieman, M. and Stevenson, N.J., Inhibition of the IFN-α JAK/STAT Pathway by MERS-CoV and SARS-CoV-1 Proteins in Human Epithelial Cells, Viruses, 14, (4), 2022
Wahaab, A. and Mustafa, B.E. and Hameed, M. and Stevenson, N.J. and Anwar, M.N. and Liu, K. and Wei, J. and Qiu, Y. and Ma, Z., Potential role of flavivirus ns2b-ns3 proteases in viral pathogenesis and anti-flavivirus drug discovery employing animal cells and models: A review, Viruses, 14, (1), 2022
Farid, E. and Herrera-Uribe, J. and Stevenson, N.J., The Effect of Age, Gender and Comorbidities Upon SARS-CoV-2 Spike Antibody Induction After Two Doses of Sinopharm Vaccine and the Effect of a Pfizer/BioNtech Booster Vaccine, Frontiers in Immunology, 13, (817597), 2022
Gargan, S. and Stevenson, N.J., Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease, Viruses, 13, (11), 2021
The interplay between the immune system and viruses in, 2021, pp1-15 , [Wubben, R. and Efstathiou, C. and Stevenson, N.J.]
McKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, Kelly LA, Stevenson NJ, Little MA, Molloy EJ, Neutrophils: Need for Standardized Nomenclature., Frontiers in immunology, 2021
Alqahtani, M. and Mallah, S.I. and Stevenson, N. and Doherty, S., Vaccine trials during a pandemic: potential approaches to ethical dilemmas, Trials, 22, (1), 2021
Almadhi, M.A. and Abdulrahman, A. and Sharaf, S.A. and AlSaad, D. and Stevenson, N.J. and Atkin, S.L. and AlQahtani, M.M., The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19, International Journal of Infectious Diseases, 105, 2021, p656-661
Zhang, Y. and Gargan, S. and Lu, Y. and Stevenson, N.J., An overview of current knowledge of deadly covs and their interface with innate immunity, Viruses, 13, (4), 2021
Efstathiou C, Abidi SH, Harker J and Stevenson NJ., Revisiting Respiratory Syncytial Virus's Interaction with Host Immunity, Towards Novel Therapeutics, Cellular and Molecular Life Sciences, 2020
Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C and Stevenson NJ, The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3, The FASEB Journal, 33, (8), 2019, p8732 - 8744
Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216
Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight à , Stevenson NJ., Control of HIV infection by IFN-alpha: implications for latency and a cure., Cellular and molecular life sciences : CMLS, 75, (5), 2018, p775-783
Raftery N and Stevenson NJ, Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway., Cellular and Molecular Life Sciences, 74, (14), 2017, p2525-2535
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764
Mahony R, Ahmed S, Diskin C, Stevenson NJ, SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?, Cellular and Molecular Life Sciences, 73, (17), 2016, p3323 - 3336
Lui PY, Jin DY, Stevenson NJ., MicroRNA: master controllers of intracellular signaling pathways., Cellular and Molecular Life Sciences, 72, (18), 2015, p3531 - 3542
Murray C1, Griffin ÉW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A, Cunningham C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C., Brain, Behaviour and Immunity,, 48, 2015, p274 - 286
Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63
Collins, A.S. Ahmed, S. Napoletano, S. Schroeder, M. Johnston, J.A. Hegarty, J.E. O'Farrelly, C. Stevenson, N.J., Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-- responses, Journal of Leukocyte Biology, 96, (2), 2014, p255 - 263
HCV Immune Evasion in, Hepatitis C Virus: Molecular Pathways and Treatments, OMICS group, 2014, [Napoletano S, Bannan C, Bergin C and Stevenson NJ]
Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-
Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090
Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578
Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866
Ryan, E.J., Stevenson, N.J., Hegarty, J.E., O'Farrelly, C., Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation, Journal of Viral Hepatitis , 18, (12), 2011, p840-851
De La Vega, M., Kelvin, A.A., Dunican, D.J., McFarlane, C., Burrows, J.F., Jaworski, J., Stevenson, N.J., Dib, K., Rappoport, J.Z., Scott, C.J., Long, A., Johnston, J.A., The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility, Nature Communications, 2, (1), 2011, p259
Ryan, E.J., Dring, M., Ryan, C.M., McNulty, C., Stevenson, N.J., Lawless, M.W., Crowe, J., Nolan, N., Hegarty, J.E., O'Farrelly, C., Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832
Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474
Stevenson, N.J., Addley, M.R., Ryan, E.J., Boyd, C.R., Carroll, H.P., Paunovic, V., Bursill, C.A., Miller, H.C., Channon, K.M., McClurg, A.E., Armstrong, M.A., Coulter, W.A., Greaves, D.R., Johnston, J.A., CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression, Journal of Leukocyte Biology, 85, (2), 2009, p289-297
Elliott, J., Lynch, O.T., Suessmuth, Y., Qian, P., Boyd, C.R., Burrows, J.F., Buick, R., Stevenson, N.J., Touzelet, O., Gadina, M., Power, U.F., Johnston, J.A., Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase, Journal of Virology, 81, (7), 2007, p3428-3436
The Role of the Immune System in Cancer. in, Infection in the cancer patient., Oxford University Press, 2006, pp19 - 41, [Stevenson NJ and Johnston JA. ]
Sommer, U., Schmid, C., Sobota, R.M., Lehmann, U., Stevenson, N.J., Johnston, J.A., Schaper, F., Heinrich, P.C., Haan, S., Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation: Contributions of Src- and receptor-tyrosine kinases, Journal of Biological Chemistry, 280, (36), 2005, p31478-31488
Stevenson, Nigel, Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation, The Journal of Biological Chemistry, 280, (36), 2005, p31478 - 31488
Stevenson, N.J., Haan, S., McClurg, A.E., McGrattan, M.J., Armstrong, M.A., Heinrich, P.C., Johnston, J.A., The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression, Journal of Immunology, 173, (5), 2004, p3243-3249
Non-Peer-Reviewed Publications
Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744
Kelly A, Fahey R, Keogh C, Stevenson NJ, CarrollA , Siddachari R, Geoghegan J, Hegarty JE, Ryan EJ, O'Farrelly C, Cd141+ (bdca-3+) interferon lambda (ifn-λ)-producing dendritic cells are depleted in hepatitis C virus-infected liver, Immunology, 2011, 135, 2011, pp111
Stevenson NJ, Ryan EJ, Keogh CA, Lloyd AT, Cormican P, Hegarty JE, O'Farrelly C. , Hepatitis C virus (HCV) regulates signal transducer and activator of transcription (STAT) protein expression to escape interferon-alpha (IFN-alpha) responses. , Immunology, 125, (1), 2008, pp71
Armstrong MA, McClurg AE, Stevenson NJ, Hawkins SA, Johnston JA. , Timing of exposure to interferon beta can alter conventional dendritic cell precursor cell differentiation by upregulating IKBzeta and downregulating NFkB2/p52. , Immunology, 120, (1), 2007, pp36
Stevenson NJ, Addely M, Greaves D, Johnston J. , Chemokines regulate innate immunity and chemotaxis through Suppressor Of Cytokine Signalling (SOCS) proteins., Clinical Immunology, 2006, ppS127
Stevenson NJ, Haan S, McClurg A, Armstrong MA, Heinrich P, Johnston JA. , The chemoattractants IL-8 and fMLP regulate G-CSF signalling by inducing suppressor of cytokine signalling (SOCS)-1 expression., Immunology, 116, (1), 2005, pp73
Stevenson NJ, Haan S, McClurg AE, McGrattan MJ, Armstrong MA, Heinrich PC, JA Johnston, The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine, Journal of Immunology, 173, (5), 2004, pp3243 - 3249