Publications and Further Research Outputs
Peer-Reviewed Publications
Ryan, Emer and Kelly, Lynne and Melo, Ashanty and Morgan, Cian and Bates, Mark and Huggard, Dean and Stacey, Catherine and Duff, Eimear and Leonard, Ann and Boran, Gerard and Doherty, Dermot and Crimmins, Darach and Bolger, Turlough and Molloy, Eleanor, Altered Inflammasome and Immune activation in Paediatric Traumatic Brain Injury, 2024, -
Allen J, Isaza-Correa J, Kelly L, Melo A, Mahony A, McDonald D, Molloy EJ., Severe neurological impairment and immune function: altered neutrophils, monocytes, T lymphocytes, and inflammasome activation., Pediatric research, 2024
Eliwan HO, Watson WRG, Melo AM, Kelly LA, Omer M, Jafar A, O'Hare FM, Downey P, Mooney EE, O'Neill A, Blanco A, Regan I, Philbin B, O'Rourke M, Nolan B, Smith O, Molloy EJ., Selective modulation of monocyte and neutrophil responses with activated protein C in preterm infants., J Matern Fetal Neonatal Med, 36, (1), 2023, p2183467
Kelly, Lynne A and Branagan, Aoife and Semova, Gergana and Molloy, Eleanor J, Sex differences in neonatal brain injury and inflammation, Frontiers in immunology, 14, 2023, p1243364
Isaza-Correa J, Ryan L, Kelly L, Allen J, Melo A, Jones J, Huggard D, Ryan E, Ó Maoldomhnaigh C, Geoghehan S, Gavin P, Leahy TR, Butler K, Freyne B, Molloy EJ., Innate immune dysregulation in multisystem inflammatory syndrome in children (MIS-C)., Scientific reports, 13, (1), 2023, p16463
Aslam, Saima and O'Dea, Mary and Kelly, Lynne A and O'Neill, Amanda and McKenna, Ellen and Hurley, Tim and Branagan, Aoife and O'Driscoll, David and Normile, Caoimhe and Saleemi, Shahid and Sweetman, Deirdre and Vavasseur, Claudine and Murphy, John and Donoghue, Veronica and Watson, William and Molloy, Eleanor J, Melatonin Alters Innate Immune Function in Infants with Neonatal Encephalopathy, Neonatology, 120, (3), 2023, p325â"333
Ní Bhroin M, Kelly L, Sweetman D, Aslam S, O'Dea MI, Hurley T, Slevin M, Murphy J, Byrne AT, Colleran G, Molloy EJ, Bokde ALW., Relationship Between MRI Scoring Systems and Neurodevelopmental Outcome at Two Years in Infants With Neonatal Encephalopathy., Pediatr Neurol, (126), 2022, p35 - 42
Hassan Eliwan and Murwan Omer and Ellen McKenna and Lynne A. Kelly and Beatrice Nolan and Irene Regan and Eleanor J. Molloy, Protein C Pathway in Paediatric and Neonatal Sepsis, Frontiers in Pediatrics, 9, 2022
Huggard D, Kelly L, Worrall A, Gallagher G, Fallah L, Yoo LL, McGrane F, Lagan N, .Roche E, Balfe J, Doherty DG, Molloy EJ, Melatonin as an immunomodulator in children with Down syndrome, Pediatric Research, 2022
Zakharchenko, Lyudmyla and El-Khuffash, Afif and Hurley, Tim and Kelly, Lynne and Melo, Ashanti and Padden, Maureen and Franklin, Orla and Molloy, Eleanor J, Infants with Down syndrome and congenital heart disease have altered peri-operative immune responses, Pediatric research, 92, (6), 2022, p1716â"1723
D Sweetman, T Strickland, E Isweisi, L Kelly, M Slevin, V Donoghue, J Meehan, GB Boylan, JF Murphy, A El"Khuffash, EJ Molloy, Multi"Organ Dysfunction Scoring in Neonatal Encephalopathy (MODE Score) and Neurodevelopmental Outcomes, Acta Paediatrica, 2021
Sweetman DU, Strickland T, Melo AM, Kelly LA, Onwuneme C, Watson WR, Murphy JFA, Slevin M, Donoghue V, O'Neill A, Molloy EJ., Neonatal Encephalopathy is associated with altered Interleukin-8 and Granulocyte-Macrophage colony-stimulating factor (GMCSF) which correlates with outcomes., Frontiers in Pediatrics, 2021
Edward Beamer, Mary Isabel O'Dea, Aisling A Garvey, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Andreea Pave, Sean Quinlan, Mariana Alves, Eva M Jimenez-Mateos, Faming Tian, Eugene Dempsey, Nicholas Dale, Deirdre M Murray, Geraldine B Boylan, Eleanor J Molloy, Tobias Engel , Novel point-of-care diagnostic method for Neonatal Encephalopathy using purine nucleosides, Frontiers in Molecular Neuroscience, 2021
, Gender and Immune Function in Newborn Infants: The Role of Estrogen, Authorea Preprints, 2021
McKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, Kelly LA, Stevenson NJ, Little MA, Molloy EJ, Neutrophils: Need for Standardized Nomenclature., Frontiers in immunology, 2021
O'Dea MI, Kelly L, McKenna E, Melo AM, Ni Bhroin M, Hurley T, Byrne AT, Colleran G, Vavasseur C, El-Khuffash A, Miletin J, Murphy J, Hickey F, Molloy EJ, Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia., Frontiers in pediatrics, 2021
Nawal A B Taher, Lynne A Kelly, Alhanouf I Al-Harbi, Mary I O'Dea, Zunera Zareen, Emer Ryan, Eleanor J Molloy, Derek G Doherty, Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy, Journal of Neuroimmunology, 2021
Lynne A. Kelly, Mary I. O"Dea, Zunera Zareen, Ashanty M. Melo, Ellen McKenna, Tammy Strickland, Victoria Mc Eneaney, Veronica Donoghue, Geraldine Boylan, Deirdre Sweetman, John Butler, Claudine Vavasseur, Jan Miletin, Afif F.El"Khuffash, Luke A.J. O"Neill, John J. O"Leary, Eleanor J. Molloy, Altered Inflammasome activation in Neonatal Encephalopathy persists in Childhood, Clinical & Experimental Immunology, 2021
Ryan E, Kelly L, Stacey C, Duff E, Huggard D, Leonard A, Boran G, McCollum D, Doherty D, Bolger T, Molloy EJ, Traumatic Brain Injury in Children: Glial fibrillary Acidic Protein and Clinical Outcomes., Pediatric emergency care, 2021
Ni Bhroin Megan, Kelly Lynn A, Sweetman Deirdre, Aslam Saima, Hurley Tim, Slevin Marie, Murphy John, Byrne Angela T, Colleran Gabrielle, Molloy Eleanor J, Bokde Arun LW, A Comparison of MRI Scoring Systems Predictive Ability for Two-Year Neurodevelopmental Outcome in Neonatal Encephalopathy, SSRN Electronic Journal, 2021
Zunera Zareen, John Allen, Lynne A. Kelly, Denise McDonald, Deirdre Sweetman, Eleanor J. Molloy, An observational study of sleep in childhood post"neonatal encephalopathy, Acta Paediatrica, 2021
Ryan E, Kelly L, Stacey C, Huggard D, Duff E, McCollum D, Leonard A, Boran G, Doherty DR, Bolger T, Molloy EJ., Mild To Severe Traumatic Brain Injury In Children: Altered Cytokines Reflect Severity, 2021
O'Dea M. I., Kelly L. A., McKenna E., Strickland T., Hurley T. P., Butler J., Vavasseur C., El-Khuffash A. F., Miletin J., Fallah L., White A., Wyse J., Molloy E. J., Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes., Frontiers in pediatrics, 9, 2021, p734540
Zareen Z, Zareen Z, Strickland T, Eneaney VM, Kelly LA, McDonald D, Sweetman D, Molloy EJ, Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy, 2020
Omer M, Melo AM, Kelly L, Mac Dermott EJ, Leahy TR, Killeen O, Saugstad OD, Savani RC, Molloy EJ., Emerging Role of the NLRP3 Inflammasome and Interleukin-1ß in Neonates., Neonatology, 117, (5), 2020, p545-554
Dietrick B, Molloy E, Massaro AN, Strickland T, Zhu J, Slevin M, Donoghue V, Sweetman D, Kelly L, O'Dea M, McGowan M, Vezina G, Glass P, Vaidya D, Everett AD, Plasma and Cerebrospinal Fluid Candidate Biomarkers of Neonatal Encephalopathy Severity and Neurodevelopmental Outcomes., The Journal of pediatrics, 2020
Zareen Z, Strickland T, Fallah L, McEneaney V, Kelly L, McDonald D, Molloy EJ., Cytokine dysregulation in children with cerebral palsy, Developmental Medicine & Child Neurology, 2020
Deirdre U. Sweetman, Lynne Kelly, Tim Hurley, Chike Onwuneme, R. William Gordon Watson, John F. A. Murphy, Marie Slevin, Veronica Donoghue, Eleanor J. Molloy, Troponin T correlates with MRI results in neonatal encephalopathy, Acta Paediatrica, 2020
Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938
O'Dea M, Sweetman D, Bonifacio SL, El-Dib M, Austin T, Molloy EJ, Management of Multi Organ Dysfunction in Neonatal Encephalopathy., Frontiers in pediatrics, 2020
Sweetman DU, Strickland T, Melo AM, Kelly LA, Onwuneme C, Watson WR, Murphy JFA, Slevin M, Donoghue V, O'Neill A, Molloy EJ, Neonatal Encephalopathy Is Associated With Altered IL-8 and GM-CSF Which Correlates With Outcomes., Frontiers in pediatrics, 2020
, GP124 IL1-$ß$ levels at presentation correlate with symptom burden at 2 weeks in paediatric mild traumatic brain injury, 2019
Sweetman D, Kelly LA, Zareen Z, Nolan B, Murphy J, Boylan G, Donoghue V, Molloy EJ., Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy., Frontiers in pediatrics, 2019
, GP98 IL1-$ß$ levels at presentation with paediatric mild traumatic brain injury are higher in children with previous mild traumatic head injuries, 2019
, GP191 Dysregulation of the inflammasome in children with Down syndrome, 2019
Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ., Altered Toll-Like Receptor Signalling in Children with Down Syndrome., Mediators of inflammation, 2019, 2019, p4068734
Tewari P, White C, Kelly L, Pilkington L, Keegan H, D'Arcy T, Toole SO, Sharp L, O'Leary JJ, Martin CM., Clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay in the management of women referred to colposcopy with minor cytological abnormalities., Diagnostic cytopathology, 46, (12), 2018, p987-992
Varga N, Mózes J, Keegan H, White C, Kelly L, Pilkington L, Benczik M, Zsuzsanna S, Sobel G, Koiss R, Babarczi E, Nyíri M, Kovács L, Attila S, Kaltenecker B, Géresi A, Kocsis A, O'Leary J, Martin CM, Jeney C., The Value of a Novel Panel of Cervical Cancer Biomarkers for Triage of HPV Positive Patients and for Detecting Disease Progression., Pathology oncology research : POR, 23, (2), 2017, p295-305
Varga N, Mózes J, Keegan H, White C, Kelly L, Pilkington L, Benczik M, Zsuzsanna S, Sobel G, Koiss R, Babarczi E, Nyíri M, Kovács L, Attila S, Kaltenecker B, Géresi A, Kocsis A, O'Leary J, Martin CM, Jeney C., The value of a novel panel of cervical cancer biomarkers for triage of HPV positive patients and for detecting disease progression, Pathology & Oncology Research, 2017
, Application of Triage Markers for Management of HPV Positive Women Presenting at Colposcopy with Minor Cytological Abnormalities, United States & Canadian Academy of Pathology 105th Annual Meeting, 2016
Rayman, M.P., Searle, E., Kelly, L., Johnsen, S., Bodman-Smith, K., Bath, S.C., Mao, J., Redman, C.W.G., Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: A randomised, controlled pilot trial, British Journal of Nutrition, 112, (1), 2014, p99-111
Kelly LA, Seidlova-Wuttke D, Wuttke W, O'Leary JJ, Norris LA, Estrogen receptor alpha augments changes in hemostatic gene expression in HepG2 cells treated with estradiol and phytoestrogens. , Phytomedicine , 21, (2), 2014, p155 - 158
Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103
Brosnan JF, Sheppard BL, Kelly LA, O'Leary JJ, Norris LA, Norethisterone acetate alters coagulation gene expression in vitro in human cell culture., Thrombosis research, 131, (1), 2013, p72 - 77
, Haemostatic and Angiogenic Dysregulation in Preeclampsia, REPRODUCTIVE SCIENCES, 2012
Lynne Kelly, Shanthi Muttukrishna, Lucy Norris, John Higgins, P10. Placental expression of haemostatic and angiogenic markers in preeclampsia, Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 1, (3-4), 2011, p277
Kelly LA, O'Leary JJ, Seidlova-Wuttke D, Wuttke W, Norris LA, Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens, Thrombosis and Haemostasis, 104, (6), 2010, p1083-1289
Laios A, O'Toole S, Flavin R, Martin C, Kelly L, Ring M, Finn SP, Barrett C, Loda M, Gleeson N, D'Arcy T, McGuinness E, Sheils O, Sheppard B, O' Leary J, Potential role of miR-9 and miR-223 in recurrent ovarian cancer., Molecular cancer, 7, 2008, p35
Deirdre Una Sweetman and Tammy Strickland and Eman Isweisi and Lynne Kelly and Marie Therese Slevin and Veronica Donoghue and Judith Meehan and Geraldine Boylan and John Finbar Anthony Murphy and Afif El-Khuffash and Eleanor J. Molloy, Multi-organ dysfunction scoring in neonatal encephalopathy ({MODE, Acta Paediatrica, 111, (1), p93--98
Barbara D. Friedes and Eleanor Molloy and Tammy Strickland and Jie Zhu and Marie Slevin and Veronica Donoghue and Deirdre Sweetman and Lynne Kelly and Mary O'Dea and Aurelie Roux and Robert Harlan and Gregory Ellis and Cedric Manlhiot and David Graham and Frances Northington and Allen D. Everett, Neonatal encephalopathy plasma metabolites are associated with neurodevelopmental outcomes, Pediatric Research, 92, (2), p466--473
Murwan Omer and Ashanty Maggvie Melo and Lynne Kelly and Emma Jane Mac Dermott and Timothy Ronan Leahy and Orla Killeen and Ola Didrik Saugstad and Rashmin C. Savani and Eleanor J. Molloy, Emerging Role of the {NLRP, Neonatology, 117, (5), p545--554
Non-Peer-Reviewed Publications
Phytoestrogens activate the estrogen receptor in HepG2 cells in, Methods in Molecular Biology, 2017, [Kelly, LA]
Robertson IH, Traumatic Brain Injury, Baycrest Conference, Toronto, March, 1999