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Dr. Heike Hawerkamp
Research Fellow, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Dwivedi, A. and Mhaonaigh, A.U. and Carroll, M. and Khosravi, B. and Batten, I. and Ballantine, R.S. and Phelan, S.H. and O†Doherty, L. and George, A.M. and Sui, J. and Hawerkamp, H.C. and Fallon, P.G. and Noppe, E. and Mason, S. and Conlon, N. and Cheallaigh, C.N. and Finlay, C.M. and Little, M.A., Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19, JCI Insight, 9, (17), 2024 Journal Article, 2024 DOI

Roberts J, Chevalier A, Hawerkamp HC, Yeow A, Matarazzo L, Schwartz C, Hams E, Fallon PG., Retinoic Acid-Related Orphan Receptor " Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation., Journal of immunology (Baltimore, Md. : 1950), 211, (4), 2023, p626-632 Journal Article, 2023 DOI

Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023 Journal Article, 2023

Mylonas A, Hawerkamp HC, Wang Y, Chen J, Messina F, Demaria O, Meller S, Homey B, Di Domizio J, Mazzolai L, Hovnanian A, Gilliet M, Conrad C., Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea., JCI insight, 8, (4), 2023, pe151846 Journal Article, 2023 DOI

Schwartz C, Schmidt V, Deinzer A, Hawerkamp HC, Hams E, Bayerlein J, Röger O, Bailer M, Krautz C, El Gendy A, Elshafei M, Heneghan HM, Hogan AE, O'Shea D, Fallon PG., Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity., Science translational medicine, 14, (635), 2022, peabj6879 Journal Article, 2022 DOI

Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Cian Mangan, Fergal Howley, Siobhan O'Regan, Noor Adeebah Mohamed Razif, Ciara Conlan, Ruth Argue, Samuel Holohan, Adam Dyer, Fara Salleh, Liam Townsend, Gerard Hughes, Colm Kerr, Derval Reidy, Alberto Sanz, Emma Connolly, Andrea Kelly, Emma Leacy, Conor Reddy, Siobhan Gargan, Eamon Breen, Heike Hawerkamp, Jean Dunne, Ignacio Martin-Loeches, Anne Marie McLaughlin, Aideen Long, Orla Shiels, Padraic Fallon, Martina Hennessy, Roman Romero-Ortuno, Ciaran Bannan, Anna Rose Prior, Ana Rakovac, William McCormack, Ross McManus, Seamus Donnelly, Colm Bergin, Mark Little, Clíona Ní Cheallaigh, Niall Conlon, Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19, HRB Open Research, 2022 Journal Article, 2022 DOI

Hawerkamp HC, Fallon PG., Expelliarmus helminthus! Harry Helminth and the Goblet of Alarmins. , Immunity, 2022, p575- Journal Article, 2022

Drakeford, C. and Aguila, S. and Roche, F. and Hokamp, K. and Fazavana, J. and Cervantes, M.P. and Curtis, A.M. and Hawerkamp, H.C. and Dhami, S.P.S. and Charles-Messance, H. and Hackett, E.E. and Chion, A. and Ward, S. and Ahmad, A. and Schoen, I. and Breen, E. and Keane, J. and Murphy, R. and Preston, R.J.S. and O†Sullivan, J.M. and Sheedy, F.J. and Fallon, P. and O†Donnell, J.S., von Willebrand factor links primary hemostasis to innate immunity, Nature Communications, 13, (1), 2022 Journal Article, 2022 DOI

Hawerkamp HC, Fahy CMR, Fallon PG, Schwartz C, Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis, Skin Health Diseases, (16), 2022, p99- Journal Article, 2022

Bone R, Fennell BJ, Tam A, Sheldon R, Nocka K, Varghese S, Chang CS, Hawerkamp HC, Yeow A, Saunders SP, Hams E, Walsh PT, Cunningham O, Fallon PG, Discovery and multi-parametric optimization of a high-affinity antibody against Interleukin-25 with neutralizing activity in a mouse model of skin inflammation. , Antibody Therapeutics, 29, 2022, p258 - 267 Journal Article, 2022

Hawerkamp HC, Domdey A, Radau L, Sewerin P, Oláh P, Homey B, Meller S., Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation., Arthritis research & therapy, 23, (1), 2021, p144 Journal Article, 2021 DOI

Hawerkamp HC, van Geelen L, Korte J, Di Domizio J, Swidergall M, Momin AA, Guzmán-Vega FJ, Arold ST, Ernst J, Gilliet M, Kalscheuer R, Homey B, Meller S., Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis., Scientific reports, 10, (1), 2020, p17178 Journal Article, 2020 DOI

Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T, Homey B, Meller S., Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events., Allergy, 74, (12), 2019, p2437-2448 Journal Article, 2019 DOI

Palm AK, Friedrich HC, Kleinau S., Nodal marginal zone B cells in mice: a novel subset with dormant self-reactivity., Scientific reports, 6, 2016, p27687 Journal Article, 2016 DOI

Palm AK, Friedrich HC, Mezger A, Salomonsson M, Myers LK, Kleinau S., Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis., Cellular & molecular immunology, 12, (4), 2015, p493-504 Journal Article, 2015 DOI

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M., T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26., Nature immunology, 16, (9), 2015, p970-979 Journal Article, 2015 DOI

Non-Peer-Reviewed Publications

, 2022 International Women's Day - yEFIS highlights outstanding women vaccine researchers., European journal of immunology, 52, (4), 2022, p537-540 Journal Article, 2022 DOI

Ali N, Baumann C, de Castro Kroner J, Do NN, Friedrich HC, Haas K, Klaeschen AS, Pfaff C, Plesser K, Pollet M, Schmidt J, Schneeweiss M, Siewert MM, Stock M, Sucker N, Üstün Y, Vollmer V, Wachsmuth E, Wang J, Schilling B, Fabri M, Loser K, Eming SA., Round Table - new concept of the Arbeitsgemeinschaft Dermatologische Forschung to foster regional exchange between young clinician scientists in dermatology., Experimental dermatology, 25, (10), 2016, p827-828 Journal Article, 2016 DOI

Research Expertise

Keywords

Adaptive Immunity; Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis); DERMATOLOGY; HAEMOPHILIA; IMMUNOLOGY; Infection and immunity; Innate immunology; TB immunology