Biography
Adam Dyer is an ICAT fellow and SpR in Geriatric Medicine/GIM (2021-28). Adam graduated from Medicine (TCD) in 2017 and holds Masters degrees in Neuroscience (Intercalated MSc) and Medical Gerontology (Research MSc) in addition to a Postgraduate Certificate in Statistics. Adam has published over 60 journal papers and his translational immunology research focuses on exploring the impact of age and frailty on immune system variability and how this variability influences the pathogenesis and progression of age-related disease - in particular cognitive impairment and dementia due to alzheimer disease.
Publications and Further Research Outputs
Peer-Reviewed Publications
Helena Dolphin, Adam H Dyer, Laura Morrison, Susan D Shenkin, Tomas Welsh, Sean P Kennelly, New horizons in the diagnosis and management of Alzheimer"s Disease in older adults, Age and Ageing, 53, (2), 2024
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Aoife Fallon, Sean O'Dowd, Nollaig M Bourke, Sean P Kennelly, Performance of plasma p-tau217 for the detection of amyloid-ß positivity in a memory clinic cohort using an electrochemiluminescence immunoassay, Alzheimer's Research & Therapy, 2024
Laura Morrison, Adam H Dyer, Helena Dolphin, Isabelle Killane, Nollaig M Bourke, Matthew Widdowson, Conor P Woods, James Gibney, Richard B Reilly, Sean P Kennelly, Discrete Relationships between Spatiotemporal Gait Characteristics and Domain-Specific Neuropsychological Performance in Midlife, Sensors, 2024
Adam H Dyer, Helene McNulty, Aoife Caffrey, Shane Gordon, Eamon Laird, Leane Hoey, Catherine F Hughes, Mary Ward, J J Strain, Maurice O'Kane, Fergal Tracey, Anne M Molloy, Conal Cunningham, Kevin McCarroll, Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study, Neurobiol Aging, 2024
Belinda Hernández, Adam H Dyer, Ciaran Finucane, Bernardo Nipoti, Roman Romero-Ortuno, Richard Reilly, Rose Anne Kenny, The Impact of Type 2 Diabetes on Peripheral and Cerebral Haemodynamic Responses to Active Stand, The Journals of Gerontology: Series A, 2024
Adam H Dyer, Claire Murphy, Helena Dolphin, Laura Morrison, Robert Briggs, Brian Lawlor, Sean P Kennelly; NILVAD Study Group, Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer's disease, European Geriatric Medicine, 2024
Emma J Leacy 1, Jia Wei Teh 2, Aoife M O'Rourke 3, Gareth Brady 1, Siobhan Gargan 4, Niall Conlon 5, Jennifer Scott 1, Jean Dunne 5, Thomas Phelan 1, Matthew D Griffin 2 6, Julie Power 7, Aoife Mooney 5, Aifric Naughton 5, Rachel Kiersey 5, Mary Gardiner 5, Caroline O'Brien 5, Ronan Mullan 4 8, Rachael Flood 4 8, Michael Clarkson 9, Liam Townsend 10, Michelle O'Shaughnessy 2 9, Adam H Dyer 11, Barry Moran 3, Jean M Fletcher 3, Lina Zgaga 12, Mark A Little 1; RITA Ireland Vasculitis Biobank, Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination, 2024
L Morrison, AH Dyer, H Dolphin, I Batten, C Reddy, M Widdowson, CP Woods, J Gibney, NM Bourke, SP Kennelly, Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes, Brain, Behavior, & Immunity - Health, 41, (November), 2024, p100862-
Dyer AH, Dolphin H, Welsh T, Soysal P, Roitto HM, Religa D, Kennelly SP, EuGMS Special Interest Group in Dementia, Emerging Disease Modifying Therapies for Older Adults with Alzheimer Disease: Perspectives from the EuGMS Special Interest Group in Dementia, EUROPEAN GERIATRIC MEDICINE, 2023
Murphy C, Dyer AH, Lawlor B, Kennelly SP, for the NILVAD study group, What is the impact of ongoing statin use on cognitive decline and dementia progression in older adults with mild-moderate Alzheimer disease?, PLoS ONE, 2023
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Emily Killeen, Conal Gallagher, Naomi Davey, Eimear Connolly, Shane Lyons, Conor Young, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Nollaig M Bourke, Aoife Fallon, Sean O'Dowd, Sean P Kennelly, Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration, BMJ Open, 2023
Adam. H Dyer, Helena Dolphin, Matt McElheron, Nollaig M Bourke, Sean P Kennelly, Moving from "Vulnerability" to "Variability" in Defining a Place for the Biology of Aging in Geriatric Medicine. , European Geriatric Medicine, 2023
Dolphin H, Dyer AH, McHale C, O'Dowd S, Kennelly SP, An Update on Apathy in Alzheimer's Disease, Geriatrics (Basel), 2023
Gordon Greville, Sinead Cremen, Shauna O'Neill, Sarah Azarian, Gareth Brady, William McCormack, Adam H Dyer, Nollaig M Bourke, Olivier Touzelet, David Courtney, Ultan F Power, Paul Dowling, Tom K Gallagher, Connor G G Bamford, Mark W Robinson, Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis, Clin Exp Immunol ., 2023
Dolphin H, Dyer AH, Dukelow T, Finucane C, Commins S, Kennelly SP, Safety and Feasibility of Transcutaneous Vagus Nerve Stimulation in Mild Cognitive Impairment: VINCI-AD Study Protocol, BMC Neurology, 2023
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236
Garcia L, Woudenberg T, Rosado J, Dyer AH, Donnadieu F, Planas D, Bruel T, Schwartz O, Prazuck T, Velay A, Fafi-Kremer S, Batten I, Reddy C, Connolly E, McElheron M, Kennelly SP, Bourke NM, White MT, Pelleau S, Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination, Viruses, 2022
STARSurg Collaborative and EuroSurg Collaborative., Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery. , BJS Open, 6, (1), 2022, pzrab150
Dyer AH, Laird E, Hoey L, Hughes CF, McNulty H, Ward M, Strain JJ, O'Kane M, Tracey F, Molloy AM, Cunningham C, Sexton DJ, McCarroll K, Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults, International Journal of Geriatric Psychiatry, 2022
Herings PMR, Dyer AH, Kennelly SP, Reid S, Killane I, McKenna L, Bourke NM, Woods CP, O'Neill D, Gibney J, Reilly RB, Gait Characteristics and Cognitive Function in Middle-Aged Adults with and without Type 2 Diabetes Mellitus: Data from ENBIND, Sensors, 2022
Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Cian Mangan, Fergal Howley, Siobhan O'Regan, Noor Adeebah Mohamed Razif, Ciara Conlan, Ruth Argue, Samuel Holohan, Adam Dyer, Fara Salleh, Liam Townsend, Gerard Hughes, Colm Kerr, Derval Reidy, Alberto Sanz, Emma Connolly, Andrea Kelly, Emma Leacy, Conor Reddy, Siobhan Gargan, Eamon Breen, Heike Hawerkamp, Jean Dunne, Ignacio Martin-Loeches, Anne Marie McLaughlin, Aideen Long, Orla Shiels, Padraic Fallon, Martina Hennessy, Roman Romero-Ortuno, Ciaran Bannan, Anna Rose Prior, Ana Rakovac, William McCormack, Ross McManus, Seamus Donnelly, Colm Bergin, Mark Little, Clíona Ní Cheallaigh, Niall Conlon, Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19, HRB Open Research, 2022
Dyer AH, Batten I, Reddy C, Townsend L, Woods CP, O'Neill D, Gibney J, Kennelly SP, Bourke NM, Neuropsychological Decrements in Midlife Type-2 Diabetes are Not Associated with Peripheral NLRP3 Inflammasome Responsiveness, Frontiers in Immunology, 2022
Dyer AH, Noonan C, McElheron M, Batten I, Reddy C, Connolly E, Pierpoint R, Murray C, Leonard A, Higgins C, Reilly P, Boran G, Phelan T, McCormack W, O'Neill D, Fallon A, Brady G, O'Farrelly C, Bourke NM, Kennelly SP., Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents, Journal of the American Medical Directors Association, 2022
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari FS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Erikstrup C, Condino-Neto A, Prando C, Bondarenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest Group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CP-COVID-19 Group, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement Français du Sang Study group, Anderson MS, Boisson B, Béziat V, Zhang SY, Andreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Burdet C, Bouadma L, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Casanova JL, Abel L, Cobat A., The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies., Proceedings of the National Academy of Sciences of the United States of America, 119, (21), 2022, pe2200413119
Dyer AH, Fallon A, Noonan C, Dolphin H, O'Farrelly C, Bourke NM, O'Neill D, Kennelly SP, Managing The Impact Of COVID-19 in Nursing Homes and Long-Term Care Facilities: An Update, Journal of the American Medical Directors Association, 2022
A Dyer; C Noonan; R Pierpoint; A Leonard; G Boran; G Brady; A Fallon; Cliona O'Farrelly; N Bourke; S Kennelly, Previous SARS-CoV2 Infection, Age and Frailty Predict 6-Month BNT162b Vaccine-Induced Antibody Titre in Nursing Home Residents: Data from NH-COVAIR, British Geriatrics Society Spring Meeting, London, April 2022, 2022
Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021
Dyer AH, Briggs R, Laird E, Hoey L, Hughes CF, McNulty H, Ward M, Strain JJ, Molloy AM, Cunningham C, McCarroll K., Glycated Haemoglobin (HbA1c), Diabetes and Neuropsychological Performance in Community-Dwelling Older Adults, Diabetic Medicine, 2021
Adam Dyer, Claire Noonan , Matt McElheron , Isabella Batten , Conor Reddy , Emma Connolly , Rachel Pierpoint , Caroline Murray , Ann Leonard, Gerard Boran , Cliona O'Farrelly , Thomas Phelan , Aoife Fallon , Gareth Brady , Nollaig Bourke , Sean Kennelly, Declining antibody response to SARS-CoV-2 at 6 months following vaccination in nursing home residents: data from NHCOVAIR, European Union Geriatric Medicine Society, Athens, Greece, September 2021, 2021
Townsend L, Dowds J, O'Brien K, Sheill G, Dyer AH, O'Kelly B, Hynes JP, Mooney A, Dunne J, Ni Cheallaigh C, O'Farrelly C, Bourke NM, Conlon N, Martin-Loeches I, Bergin C, Nadarajan P, Bannan C., Persistent Poor Health Post-COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity., Annals of the American Thoracic Society, 2021
Adam H Dyer, Eamon Laird, Leane Hoey, Catherine F Hughes, Helene McNulty, Mary Ward, JJ Strain, Anne Molloy, Conal Cunningham, Kevin McCarroll, Long-Term Anticholinergic, Benzodiazepine and Z-Drug Use in Community-Dwelling Older Adults: What is the impact on Cognitive and Neuropyschological Performance? , International Journal of Geriatric Psychiatry, 2021
P Claffey, L Pérez-Denia, A Dyer, T McNicholas, R Briggs, C Finucane, R A Kenny, Is Orthostatic Hypotension Associated with Altered Cerebral Perfusion During Active Standing , Irish Gerontological Society Annual Scientific Meeting, 2021
Dyer AH, Murphy C, Lawlor B, Kennelly SP, For The Nilvad Study Group., Long-term antipsychotic use and cognitive decline in community-dwelling older adults with mild-moderate Alzheimer disease: Data from NILVAD., International journal of geriatric psychiatry, 36, (11), 2021, p1708-1721
Liam Townsend, Adam H Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig Bourke, Niall Conlon, Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health, Frontiers In Immunology, 2021
Geriatric Medicine Research Collaborative , Covid Collaborative , Carly Welch, Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study, Age and Ageing, 2021, p617-630
A Dyer, L Townsend, A Naughton, R Kiersey, D Holden, M Gardiner, J Dunne, C O'Farrelly, C N Cheallaigh, N Conlon, and N Bourke, EXPLORING THE IMPACT OF AGE AND FRAILTY STATUS ON THE IMMUNE RESPONSE TO COVID-19 ILLNESS USING DETAILED IMMUNO-PHENOTYPING, Irish Gerontological Society Annual Meeting, 18th November 2021, 2021
Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Manry, Jérémy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina, Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G., Lagier, Jean-Christophe, Gentile, Stéphanie, Rosen, Lindsey B., Shaw, Elana, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis, Sene, Damien, Stepanian, Alain, Megarbane, Bruno, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R., Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa, Biondi, Andrea, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M., Zhang, Yu, Snow, Andrew L., Holland, Steven M., Biggs, Catherine, Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M., Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L., Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A., El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina, Metz, Christine N., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A., Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G., Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y., Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C., Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H., Kennelly, Sean P., Bourke, Nollaig M., Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jérome, Sedkaoui, Souad Mehlal, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C., Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bonradenko, Anastasiia, Spaan, András N., Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P., Mane, Shrikant, Anderson, Mark S., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Vandreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H., Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Vasse, Marc, Gregersen, Peter K., Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D., Su, Helen C., Kisand, Kai, Okada, Satoshi, Puel, Anne, Jouanguy, Emmanuelle, Rice, Charles M., Tiberghien, Pierre, Zhang, Qian, Cobat, Aurélie, Abel, Laurent, Casanova, Jean-Laurent, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Science Immunology, 6, (62), 2021, peabl4340
Kennelly SP, Dyer AH, Noonan C, Kennelly SM, Martin A, O'Neill D, Fallon A, Asymptomatic carriage rates and case-fatality of SARS-CoV-2 infection in residents and staff in Irish nursing homes, Age and Ageing, 50, (1), 2021, p49 - 54
Liam Townsend, Adam H. Dyer, Patrick McCluskey, Kate O"Brien, Joanne Dowds, Eamon Laird, Ciaran Bannan, Nollaig M. Bourke, Cliona Ní Cheallaigh, Declan G. Byrne, Rose Anne Kenny, Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection, Nutrients, 13, (7), 2021, p2430
Liam Townsend, Adam H Dyer, Karen Jones, Jean Dunne, Rachel Kiersey, Fiona Gaffney, Laura O'Connor, Aoife Mooney, Deirdre Leavy, Katie Ridge, Catherine King, Fionnuala Cox, Kate O'Brien, Joanne Dowds, Jamie Sugrue, David Hopkins, Patricia Byrne, Tara Kingston, Cliona Ni Cheallaigh, Parthiban Nadarajan, Anne Marie McLaughlin, Nollaig M Bourke, Colm Bergin, Cliona O'Farrelly, Ciaran Bannan, Niall Conlon, Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection, PloS One, 2020
Dyer AH, Murphy C, Briggs R, Lawlor B, Kennelly SP, NILVAD Study Group, Antidepressant use and orthostatic hypotension in older adults living with mild-to-moderate Alzheimer disease., International journal of geriatric psychiatry, 2020
Dyer A, McKenna L, Gamage G, Bourke N, Killane I, Widdowson M, Woods C, Gibney J, Reilly R, O'Neill D, Kennelly S. , Cognitive performance in midlife type 2 diabetes: results from the ENBIND study, Diabetic Medicine, 2020
Dyer AH, Murphy C, Lawlor B, Kennelly SP, NILVAD StudyGroup, Sedative Load in Community-Dwelling Older Adults with Mild-Moderate Alzheimer's Disease: Longitudinal Relationships with Adverse Events, Delirium and Falls., Drugs & aging, 2020
Floyd R, Dyer AH, Kennelly SP, Non-pharmacological interventions for cognitive impairment in women with breast cancer post-chemotherapy: A systematic review., Journal of geriatric oncology, 2020
Dyer AH, Murphy C, Lawlor B, Kennelly SP, Study Group For The Nilvad, Social networks in mild-to-moderate Alzheimer disease: longitudinal relationships with dementia severity, cognitive function, and adverse events. , Aging & mental health, 2020
EuroSurg Collaborative., Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery., The British journal of surgery, 107, (2), 2020, pe161-e169
Murphy C, Dyer AH, Lawlor B, Kennelly SP, NILVAD Study Group, Potentially inappropriate medication use in older adults with mild-moderate Alzheimer's disease: prevalence and associations with adverse events., Age and ageing, 2020
Dyer AH, Lawlor B, Kennelly SP, NILVAD Study Group., Gait speed, cognition and falls in people living with mild-to-moderate Alzheimer disease: data from NILVAD., BMC geriatrics, 20, (1), 2020, p117
Dyer AH, Lawlor B, Kennelly SP, NILVAD Study Group, Sexual dimorphism in the association of APOE "4 genotype with cognitive decline and dementia progression in mild-to-moderate Alzheimer disease., International journal of geriatric psychiatry, 2020
Dyer AH, Murphy C, Lawlor B, Kennelly SP, NILVAD Study Group., Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD., Journal of the American Medical Directors Association, 21, (2), 2020, p194-200
Dyer AH, McKenna L, Batten I, Jones K, Widdowson M, Dunne J, Conlon N, Reilly R, Woods CP, O'Neill D, Gibney J, Bourke NM, Kennelly SP., Peripheral Inflammation and Cognitive Performance in Middle-Aged Adults With and Without Type 2 Diabetes: Results From the ENBIND Study, Front. Aging Neurosci, 12, 2020
Dyer AH, Murphy C, Lawlor B, Kennelly SP, NILVAD Study Group"", Long-term proton-pump inhibitor use in older adults with mild-to-moderate Alzheimer's disease: Are there cognitive consequences?, European journal of internal medicine, 2020
EuroSurg Collaborative., Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study., Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 22, (12), 2020, p2288-2297
L. Aljohmani (EuroSurg Collaborative member), Safety of Hospital Discharge Before Return of Bowel Function After Elective Colorectal Surgery, BRITISH JOURNAL OF SURGERY, 2020
Claire Murphy, Adam H Dyer, Brian Lawlor, Sean P Kennelly, Potentially Inappropriate Medications in Patients with Alzheimer's Disease: Data from NILVAD, Irish Gerontological Society Annual Scientific Meeting, Cork, 2019
Dyer AH, Murphy C, Segurado R, Lawlor B, Kennelly SP, NILVAD Study Group, Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?, The journals of gerontology. Series A, Biological sciences and medical sciences, 2019
Adam Dyer, Isabella Batten, Liam Townsend, James Gibney, Conor Woods, Nollaig M Bourke, Sean P Kennelly, Common Pathological Pathways Between Type 2 Diabetes and Dementia: Investigating the Role of the Innate Immune System, British Neuroscience Association Festival of Neuroscience, Dublin, 2019
Adam Dyer, Isabella Batten, Isabelle Killane,Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Nollaig Bourke, Sean Kennelly, LINKING DIABETES AND DEMENTIA RISK:A ROLE FOR Aβ-42 INDUCED ACTIVATION OF THE NLRP3 INFLAMMASOME? RESULTS FROM THE ENBIND STUDY, Irish Endocrine Society Annual Scientific Meeting, Galway, 2019
Dyer A, Killane I, Bourke N, Woods C, Gibney J, O'Neill D, Reilly R, Kennelly S, Does Dual-Task Gait Speed Predict Cognitive Performance in Midlife Type 2 Diabetes? Baseline Results from the ENBIND Study, Age and Ageing, Irish Gerontoloppgical Society 67th Annual Scientific Meeting, Cork, 27-28 Sept 2019, 48, (Suppl 3), 2019, ppiii3-4
Dyer AH, Briggs R, Mockler D, Gibney J, Kennelly SP, Non-Pharmacological Interventions for Cognition in Patients with Type 2 Diabetes Mellitus: A Systematic Review., Quarterly Journal Medicine, 2019
Fallon A, Kilbane L, Briggs R, Dyer A, Nabeel S, McElwaine P, Collins DR, Coughlan T, O'Neill D, RyanD, Kennelly SP, Screening for frailty in older emergency department patients: The utility of the Survey of Health, Ageing and Retirement in Europe Frailty Instrument (SHARE-FI) , QJM, 2018
Dyer AH, Foley T, O'Shea B, Kennelly SP, Dementia Diagnosis and Referral in General Practice: A Representative Survey of Irish General Practitioners, 2018
1. C. Keogh, G. Pini, A. H. Dyer, S. Bigoni, P. DiMarco, I. Gemo,, R. Reilly, D. Tropea, Clinical and Genetic Rett Syndrome Variants are Defined by Stable Electrophysiological Profiles, BMC Pediatrics, 18, (1), 2018, p333 - 348
Dyer AH, Ryan D, O'Callaghan S., 'Acopia' and 'inability to cope' remain unhelpful and pejorative labels for complexity in older adults presenting to the acute hospital., Age and ageing, 47, (3), 2018, p488
Adam Dyer, Robert Briggs, Sean Kennelly, What are the Effects of Lifestyle Interventions for Type II Diabetes Mellitus on Cognition ? A Systematic Review, Royal Academy of Medicine in Ireland Section of Interns Study Day, Dublin, January 2018, 2018
Dyer AH, Foley T, O'Shea B, Kennelly SP. , Cognitive assessment of older adults in general practice: the collateral history , Ir J Med Sci. , 2018
Adam Dyer, Shamis Nabeel, Robert Briggs, Desmond O'Neill, Sean Kennelly, Investigating Cognitive Impairment in the Emergency Department: The Role of the Informant History, Irish Gerontological Society Annual Scientific Meeting, Killarney, September 2016, 2016
Dyer A.H, Vahdatpour C, Sanfeliu A, Tropea D, The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity, Neuroscience, 325, 2016, p89 - 99
Pini G, Congiu L, Benincasa A, DiMarco P, Bigoni S, Dyer AH, Mortimer N, Della-Chiesa A, O'Leary S, McNamara R, Mitchell KJ, Gill M, Tropea D., Illness Severity, Social and Cognitive Ability, and EEG Analysis of Ten Patients with Rett Syndrome Treated with Mecasermin (Recombinant Human IGF-1)., Autism research and treatment, 2016, 2016, p5073078
Dyer AH, Nabeel S, Briggs R, O'Neill D, Kennelly SP, Cognitive assessment of older adults at the acute care interface: the informant history., Postgraduate medical journal, 2016
Vahdatpour C, Dyer A.H, Tropea D, Insulin-like growth factor 1 and related compounds in the treatment of childhood-onset neurodevelopmental disorders, Frontiers in Neuroscience, 10, (SEP), 2016
Dyer AH, Briggs R, Nabeel S, O'Neill D, Kennelly SP, The Abbreviated Mental Test 4 for cognitive screening of older adults presenting to the Emergency Department., European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2016
Briggs R, Dyer A, Nabeel S, Collins R, Doherty J, Coughlan T, O'Neill D, Kennelly SP, Dementia in the Acute Hospital: The prevalence and clinical outcomes of acutely unwell patients with dementia., QJM : monthly journal of the Association of Physicians, 2016
Non-Peer-Reviewed Publications
R Penfold, AH Dyer, Editor's View: June 2023, AGE AND AGEING, 2023
Midlife Diabetes and the Risk of Dementia: Understanding the Link in, editor(s)Colin R. Martin, Victor R. Preedy , The Neuroscience of Dementia, Elsevier, 2020, [Sean Kennelly, Adam H Dyer]
Research Expertise
Projects
- Title
- Defining the Role of Viral Infections in Early Alzheimer Disease (DRIVE-AD)
- Summary
- Alzheimer Disease (AD) affects >60,000 individuals in Ireland and is characterised by remarkable variation in clinical presentation and disease outcomes. There is an urgent need to understand the biological determinants of this variability so personalised approaches for AD prevention and treatment can be developed. Despite strong circumstantial evidence over the past two decades that viral infections (influenza, herpesviruses, viral pneumonia) increase AD risk, definitive real-world evidence is lacking. DRIVE-AD will deploy a high-throughput, low-cost assay to determine prior exposure to 50 common viral infections " several previously implicated in AD. DRIVE-AD aims to provide the first large-scale definitive evidence linking viral exposures to AD in humans to inform potential vaccination and anti-viral treatment strategies in older adults at risk of, or living with Alzheimer Disease
- Funding Agency
- Meath Foundation; Dean's Research Initiative
- Date From
- January 2024
- Date To
- July 2025
- Title
- Exploring Novel Biomarkers of Brain Health in Diabetes (ENBIND)
- Summary
- Explores the relationship of novel bioengineering (e.g spatiotemporal gait analysis) and immunology (e.g circulating pro-inflammatory cytokines, peripheral blood immune cell responses to pathogenic amyloid ß-42) markers with cognitive function in midlife type 2 diabetes. Wave 1 (N = 150) completed; Wave 2 currently underway 2022-24 (ENBIND-II) seeking to examine the relationship between these markers and longitudinal cognitive trajectories in middle-aged adults with type 2 diabetes
- Funding Agency
- Meath Foundation
- Date From
- 2019
- Date To
- 2024
- Title
- COVID-19 in Nursing Home Residents: Predicting Disease Severity, Outcomes and Antiviral Immune Responses (NH-COVAIR & NH-IMMUNE Studies)
- Summary
- Examines anti-viral immune responses in older nursing home residents including in vitro (PBMC stimulations in lab) and in vivo (SARS-CoV2 vaccine) responses. In addition to advancing understanding of the pathogenesis of viral infection in severely frail older adults, these insights offer to inform vaccine development/deployment strategies; biological sampling completed at baseline, 5 weeks & 6 months post-vaccine
- Funding Agency
- Meath Foundation
- Date From
- 2020
- Date To
- 2025
- Title
- Translating Inflammatory Biomarkers to Predict Disease Progression and Adverse Events in Mild-Moderate Alzheimer Disease (TIDE-AD)
- Summary
- Will examine the ability of systemic inflammatory biomarkers to predict clinical progression and adverse events over 18 months in older adults with mild-moderate Alzheimer Disease. TIDE-AD will also examine the impact of systemic inflammatory events to result in persistent immune dysregulation in older adults with mild-moderate Alzheimer Disease by assessing over >1,000 individual plasma and CSF samples from older 534 older adults with subjective memory complaints, mild cognitive impairment due to Alzheimer Disease and mild-moderate dementia due to Alzheimer Disease
- Funding Agency
- Meath Foundation
- Date From
- 2021
- Date To
- 2023
- Title
- Investigating the Impact of Age and Frailty on Innate Immune Responses (FRAIL-INNATE
- Summary
- Explores innate Anti-Viral immune responses in older adults living with frailty; examines how increasing frailty states are associated with alterations in innate immune responses to various agonists using whole blood immunomonitoring; recruitment based in St James's Hospital & Tallaght University Hospital
- Funding Agency
- TCD & TTMI Building Engagements in Health Research
- Date From
- 2021
- Date To
- 2023
Recognition
Representations
SpR Representative, Irish Gerontological Society (IGS) National Executive Committee (NEC)
Editorial Fellow, Age & Ageing (Journal)
Editorial Board Member, BMC Geriatrics
Awards and Honours
Presidents Prize, Irish Gerontological Society
Stefania Maggi Award, European Geriatric Medicine Society
OMorain Research Medal & Bursary (TUH)
Presidents Prize, Irish Gerontological Society
Connolly Norman Medal in Mental Disease (TCD)
John Fleetwood Medal in Gerontology
De Renzy Prize in Public Healthy and Primary Care
George Mullet Prize in Clinical Psychiatry
Novartis Prize in Neuroscience
Amulree Prize in Geriatric Medicine, Runner Up
Sheppard Memorial Prize in General Practice
Mary Ward Prize in Traffic Medicine
Health Research Board Student Scholar
Walter Smith Prize in Pharmacology & Therapeutics
British Pharmacological Society Undergraduate Prize
William Fearon Medal in Biochemistry
Scholar of Trinity College Dublin
Henry Hutchinson Medical Scholarship
John Purser Medal in Physiology and Biochemistry
Memberships
British Geriatrics Society
Irish Gerontological Society