Dr. Andrew Maree
Clinical Associate Professor, Clinical Medicine
Clinical Associate Professor, School Office - Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
L Brandon, N Connolly, M Hensey, S O'Connor, I Cruz-Gonzalez, RA Kenny, AO Maree, Cardiovascular Autonomic Dysfunction and its Association with Aortic Stenosis, Medicine Research Archives, 11, (1), 2023
Percutaneous Approach to Pericardial Disease Management in, editor(s)Alexander Berezin , Pericarditis - Diagnosis and Management Challenges, IntechOpen, IntechOpen, 2023, [Jack Hartnett, Richard Armstrong, Lisa Brandon, Igor Palacios, Hani Jneid, Andrew O. Maree]
Jack Laffan, Alexandra Foley, Charles McCreery, Peter Kearney, Gavin Blake, Tom Kiernan, James Crowley, Andrew Maree, Mark Kennedy, Robert A. Byrne, Long-Term Survival for Deferring Revascularization of Delayed-Presentation STEMI Patients, J Am Coll Cardiol Intv. 2023 Feb, 16 (4_Supplement) S5, Cardiovascular Research Technologies 2023, Washington DC, USA, 25-28th February 202, 4_supplement, American College of Cardiology, 2023, ppS5-
Anthony J. Buckley MB, BCh, BAO, Mark Hensey MB, BCh, BAO, Stephen O'Connor MD, Andrew Maree MB, MSc, PhD, Dental screening prior to transcatheter versus surgical aortic valve replacement: International Survey of Current Practices, Catheterisation and Cardiovascular Interventions, 2023, p1 - 2
Coyle M, King G, Bennett K, Maree A, Hensey M, O'Connor S, Daly C, Murphy G, Murphy RT, The use of deformation imaging in the assessment of patients pre and post transcatheter aortic valve implantation., Echo Research and Practice, 10, (1), 2023, p3-
Jack Laffan, Alexandra Foley, Charles McCreery, Peter Kearney, Gavin Blake, Andrew Maree, Tom Kiernan, James Crowley, Mark Kennedy, Robert A. Byrne, Long-Term Survival of Irish STEMI Patients Treated With Primary PCI via Femoral Versus Radial Arterial Access, J Am Coll Cardiol Intv. , Cardiovascular Research Technologies 2023, Washington DC, USA, 25-28th Feb 2023, 4_supplement, American College of Cardiology, 2023, ppS43-
G Murphy, A Naughton, R Murphy, C McCaughey, A Maree, A CT coronary angiography first strategy in patients determined to have an indication for invasive coronary angiogram, Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland , 6-8 October 2022, 108, (Suppl 3), BMJ Publishing Group Ltd and British Cardiovascular Society, 2022, ppA11 - A12
L Brandon, R Armstrong, B Kerr, C Finucane, M Afonso Shirsath, M Hensey, S O'Connor, RA Kenny, A Maree, Heart rate recovery following active stand test in patients with versus without severe aortic stenosis , Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland , 6-8 October 2022, 108, (Suppl 3), BMJ Publishing Group Ltd and British Cardiovascular Society, 2022, ppA15 - A15
R Armstrong and P Wheen and L Brandon and A Maree and R -A Kenny, Heart rate: control mechanisms, pathophysiology and assessment of the neurocardiac system in health and disease, QJM: An International Journal of Medicine, 115, (12), 2022, p806 - 812
J Laffan, A Foley, G Blake, A Maree, J Crowley, C McCreery, P Kearney, T Kiernan, P Owens, M Kennedy, RA Byrne, Survival of patients from the south-east region of Ireland following ST-elevation myocardial infarction compared with the rest of Ireland , Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland , 6-8 October 2022, 108, (Suppl 3), BMJ Publishing Group Ltd and British Cardiovascular Society, 2022, ppA54 - A55
R Bourke, S Perez, AZ Mogollo, C Finucane, M Leenders, F Roberts, G Morren, A Maree, M De Melis, RA Kenny, T Foran, MONITORING FALLS RISK IN THE COMMUNITY USING AN IMPLANTABLE CARDIAC MONITOR WITH EMBEDDED ACCELEROMETER, Age and Ageing, 51, (Suppl 3), Publisher Oxford University Press, 2022, ppafac218. 2-
Buckley AJ, McCormick JP, Carey J, Armstrong R, Maree A, Hensey M, O'Connor S, Murphy R, Daly C, Cosgrave J, Pearson , Intravascular lithotripsy-assisted PCI for severely calcified coronary lesions: evaluating the impact on quality of life and outcomes, Irish Journal of Medical Science, 2022
McGovern L, Maree AO, Look before you Leap, EuroPCR 2021, Paris, France, 18th - 21st May 2021, (A27762LM), 2021
A Buckley, J McCormick, J Carey, R Armstrong, A Maree, M Hensey, S O'Connor, R Murphy, C Daly, J Cosgrave, I Pearson, Intravascular lithotripsy-assisted PCI for severe calcific coronary disease: evaluating the impact on quality of life and outcomes, Heart, British Cardiovascular Society, 2021/10/1, 107, (Suppl2), BMJ Publishing Group Ltd and British Cardiovascular Society, 2021, ppA30 - A31
Ryan P, Edgar JD, Conlon NP, Maree AO, Delayed Hypersensitivity Reactions to Structurally Dissimilar Adenosine Diphosphate P2Y12 Platelet Receptor Inhibitors, European Heart Journal Case Reports, 2021
Richard Armstrong, Peter Wheen, Ross Murphy, Lars Nolke, Kevin Walsh, Andrew O. Maree, Atrial Septal Aneurysm Masquerading as Cor Triatriatum , European Heart Journal Case Reports, 2021
Jack Hartnett, Lisa Brandon, Deirdre Waterhouse, Ross T Murphy, Kevin P Walsh, Mark S Spence, Andrew O Maree, Case Report of Ventricular Septal Defect complicating Transcatheter Aortic Valve Implant for Aortic Regurgitation: Novel Complication and Technical Considerations , Volume 5, Issue 10, European Heart Journal Case Reports, October, 2021, https://doi.org/10.1093/ehjcr/
Bajrangee A, Cox D, Maree AO, Galectin-3 as a marker of unstable coronary plaque in chest pains patients, Atherosclerosis, 2021
Armstrong R, Wheen P, Brandon L, Maree A, Kenny RA., Share Heart Rate: Control Mechanisms, Pathophysiology and Assessment of the Neurocardiac System in Health and Disease., QJM An International Journal of Medicine, 2021
Helen O'Donnell, MPharm, MSc; Lea Trela-Larsen, PhD; Andrew Maree, PhD; Laura McCullagh, PhD; Michael Barry, PhD, Bridging the Data Gap: Mapping a National Longitudinal Study to the EQ-5D-3L, PharmacoEconomics, 2021
Tanner R, Cronin M, Macken L, Murphy R, Maree AO, Ullah I, Cosgrave J, O'Connor S, Daly C, Share Real-World Experience With Antiplatelet Agents After Percutaneous Coronary Intervention in Patients With an Indication for an Oral Anticoagulant., Journal of Cardiovascular Pharmacology, 77, (4), 2021, p501 - 507
R Armstrong, P Wheen, L Brandon, RA Kenny, A Maree, Assessment of speed of heart rate recovery as a modifiable risk factor through cardiac rehabilitation, Heart, Irish Cardiac Society Annual Scientific Meeting & AGM , Virtual, October 7th - 9th 20, 107, (Suppl2), BMJ Publishing Group Ltd and British Cardiovascular Society, 2021, ppA29 - A30
Armstrong R, Wheen P, Brandon L, Finucane C, Kenny RA, Maree A., Impaired autonomic function after incomplete revascularisation., Open Heart, (2), 2021
L McGovern, N McEniff, S Walsh, J Cosgrave, A Maree, LIMA Jeopardy CABG and Aorto-Iliac Disease, EuroIntervention, EuroPCR 2020, Paris, France, 25-27 june, 2020
R Armstrong, P Wheen, J Cosgrave, RA Kenny, A Maree, Impaired autonomic function after incomplete revascularisation., Heart, Irish Cardiac Society Annual Scientific Meeting, Virtual, 106 , (Suppl 4), BMJ Publishing Group Ltd, 2020, ppA26 - A26
A Bajrangee, S Mahabir, W Khalifa, A O Maree, B McAdam, QT Prolongation in Non-Telemetered Hospitalized Elderly Patients, Journal of Electrocardiology , 55, 2019, p91 - 96
Wheen P, Armstrong R, Maree A, O'Connor S, Late Ventricular Standstill Following an Elective TAVI, British Medical Journal Case Reports, 10, (1136), 2019, p1136-
Pericardiocentesis in, editor(s)Eric Eeckhout, Patrick W. Serruys, William Wijns, Alec Vahanian, Marc Van Sambeek, Rodney De Palma , The PCR - EAPCI Textbook Percutaneous Interventional Cardiovascular Medicine, PCR on line, PCR Publishing, 2019, [Richard Armstrong, John D. Groarke, Igor F. Palacios, Andrew O. Maree]
R Tanner, M Cronin, L Macken, S Matiullah, S O'Connor, I Ullah, J Cosgrave, A Maree, R Murphy, B Foley, C Daly, Real world experience with anti-thrombotics after percutaneous intervention in patients with an indication for an oral anticoagulant, Heart, Irish Cardiac Society Annual Scientific Meeting, Galway, Ireland, 2019/10/1, 105, (Suppl7), BMJ Publishing Group Ltd, 2019, ppA42 - A42
C T O'Connor, S O'Rourke, A Buckley, R Murphy, P Crean, B Foley, A Maree, R Ryan, M Tolan, V Young, B O'Connell, C Daly, Infective Endocarditis: A Retrospective Cohort Study, QJM An International Journal of Medicine, 112, (9), 2019, p663 - 667
B Hennessey, I Yearoo, R Murphy, S Teehan, N Connolly, S O'Connor, B Kerr, N Fitzpatrick, L Brandon, M Ali, B Foley, A Brennan, P Crean, A Maree, A single centre experience of vascular access complications of transcatheter aortic valve replacement procedures, Irish Cardiac Society Annual Scientific Meeting, Galway, Ireland, 9-2018, 104, (Issue Supp 7), 2018
A single centre experience of vascular access complications of transcatheter aortic valve replacement procedures, B Hennessey, I Yearoo, R Murphy, S Teehan, N Connolly, S O'Connor, B Kerr, N Fitzpatrick, L Brandon, M Ali, B Foley, A Brennan, P Crean, A Maree, Heart, Irish Cardiac Society Annual Scientific Meeting, 2018/10/1, 104, (Suppl7), 2018, ppA18 - A19
BRENNAN A, HENNESSEY B, FITZPATRICK N, YEAROO I, KERR B., ALI M., MAREE A., FOLEY B, CREAN P, O'CONNOR S. , Comparison of rates of pacemaker implantation between balloon-expandable and self-expanding transcatheter aortic valve prostheses, EuroIntervention, London Valves, London, England, 31-08-2018, 2018
Bajrangee A, Coughlan JJ, Teehan S, O'Connor C, Murphy RT, Foley B, Daly C, Burke D, Maree AO, Crean PA., Early and mid-term outcomes after transcatheter aortic valve implantation (TAVI) in Ireland., International journal of cardiology. Heart & vasculature, 16, 2017, p1-3
A Bajrangee, S Mahabir, M Brennan, D Cox, AO Maree, Novel inflammatory biomarkers of coronary plaque instability and rupture , Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland, 9-2017, 103, (Issue Supp 6), 2017
Bajrangee, Amrit, Coughlan JJ, Maree A, Crean P, Conscious sedation as the default anaesthetic approach for TAVI, EuroIntervention, EUROPCR 2017 , Paris, France, 16/19-05-2017, (Euro17A-POS0087), 2017
B Srinivas Prakash, V Sullivan, B Gibson, J Cosgrave, P Crean, A Maree, R Murphy, One-year outcome of multi-vessel pci versus staged pci in st elevated myocardial infarction , Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland, 9-2017, 103, (Issue Supp 6), 2017
NB Fitzpatrick, B Dalton, AO Maree, The who, the where, and the what of the irish cardiology higher specialist training scheme 1998-2017 , Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland, 9-2017, 103, (Issue Supp 6), 2017
Bajrangee A, Ryan N, Vangjeli C, Brennan M, Cox D, Shields DC, Fitzgerald D, Maree A., Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin., Thrombosis research, 146, 2016, p51-55
Maree AO, Margey RJ, Selzer F, Bajrangee A, Jneid H, Marroquin OC, Mulukutla SR, Laskey WK, Jacobs AK., Renal insufficiency, bleeding and prescription of discharge medication in patients undergoing percutaneous coronary intervention in the National Heart, Lung, and Blood Institute (NHLBI) Dynamic Registry., Cardiovascular revascularization medicine : including molecular interventions, 17, (5), 2016, p302-307
A Bajrangee, S Mahabir, L Arkins, A Lopez, M Brennan, D Cox, AO Maree, Galectin-3 as a Novel Biomarker of Unstable Coronary Plaque, Circulation, American Heart Association Annual Scientific Session, New Orleans, Louisiana, USA, Nov 12 -16 2016, 134, (1), 2016
A Bajrangee, S Mahabir, A Tierney, R Flood, JJ Coughlan, C Hickie, FA Murray, B Gorna, P Srinivas, I Ullah, V Sullivan, AO Maree, Neutrophil to lymphocyte ratio as a predictor of outcomes and plaque burden in ST segment elevation myocardial infraction (STEMI), Heart, Irish Cardiac Society Annual Scientific Meeting, 2016/10/01, 102, (Suppl9), BMJ Publishing Group Ltd, 2016, ppA20 - A21
Reed GW, Kumar A, Guo J, Aranki S, Shekar P, Agnihotri A, Maree AO, McLean DS, Rosenfield K, Cannon CP., Point-of-care platelet function testing predicts bleeding in patients exposed to clopidogrel undergoing coronary artery bypass grafting: Verify pre-op TIMI 45--a pilot study., Clinical cardiology, 38, (2), 2015, p92-98
Ryan N, Bajrangee A, Vangjeli C, Brennan M, Crean P, Kenny RA, Cox D, Shields DC, Fitzgerald DJ, Maree AO. , Impact of Genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin. , European Heart Journal, European Society of Cardiology Annual Scientific Session. Eur Heart J (2014), Barcelona, Spain, 30/08/14 - 03/09/14, (35 ), 2014, pp1167-
, An unexpected case of ventricular fibrillation cardiac arrest in a Caucasian female., BMJ case reports, 2014
Cruz-Gonzalez I, Perez-Rivera A, Lopez-Jimenez R, Rodriguez-Collado J, Martín-Moreiras J, Cascon M, Arribas A, Gomez JC, Maree AO, Martin-Luengo C., Significance of the learning curve in left atrial appendage occlusion with two different devices., Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 83, (4), 2014, p642-646
Cruz-Gonzalez I, Semigram MJ, Inglessis-Azuaje I, Sanchez-Ledesma M, Martin-Moreiras J, Jneid H, Rengifo-Moreno P, Cubeddu RJ, Maree AO, Sanchez PL, Sanchez PL, Palacios IF., Effect of elevated pulmonary vascular resistance on outcomes after percutaneous mitral valvuloplasty., The American journal of cardiology, 112, (4), 2013, p580-584
Groarke J, O'Brien J, Go G, Susanto M, Owens P, Maree AO., Cost burden of non-specific chest pain admissions., Ir J Med Sci, 182, (1), 2013, p57-61
, Pericardial Tamponade, Critical Care Medicine: Diagnosis and Management in the Adult, 2013
, Pericardiocentesis, Percutaneous Interventional Cardiovascular Medicine: The PCR-EAPCI Textbook , 2012
Percutaneous Balloon Pericardiotomy for Patients with Pericardial Effusion and Tamponade in, editor(s)Moliterno DJ, Saw J, Mukherjee D. , 1001 Questions: An Interventional Cardiology Board Review, Lippincott Williams & Wilkins, 2011, pp111 - 119, [Andrew O. Maree, Hani Jneid, Igor F. Palacios]
Cruz-Gonzalez I, Jneid H, Sanchez-Ledesma M, Cubeddu RJ, Martin-Moreiras J, Rengifo-Moreno P, Diaz TA, Kiernan TJ, Inglessis-Azuaje I, Maree AO, Sanchez PL, Sanchez PL, Palacios IF., Difference in outcome among women and men after percutaneous mitral valvuloplasty., Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 77, (1), 2011, p115-120
Maree AO, Vangjeli C, Jneid H, Ryan J, Cox D, Cannon CP, Shields DC, Fitzgerald DJ., G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial., Journal of thrombosis and haemostasis : JTH, 8, (5), 2010, p934-941
Joglar F, Kabutey NK, Maree A, Farber A., The role of stent grafts in the management of traumatic tibial artery pseudoaneurysms: case report and review of the literature., Vascular and endovascular surgery, 44, (5), 2010, p407-409
Cruz-Gonzalez I, Sanchez-Ledesma M, Sanchez PL, Sanchez PL, Martin-Moreiras J, Jneid H, Rengifo-Moreno P, Inglessis-Azuaje I, Maree AO, Palacios IF., Predicting success and long-term outcomes of percutaneous mitral valvuloplasty: a multifactorial score., The American journal of medicine, 122, (6), 2009, p581.e11-9
Maree, A.O., Fitzgerald, G.A., A roadmap for the twilight zone: Navigating United States cardiovascular career development for international trainees, Circulation, 120, (15), 2009, p1542-1549
Cubeddu RJ, Jneid H, Don CW, Witzke CF, Cruz-Gonzalez I, Gupta R, Rengifo-Moreno P, Maree AO, Inglessis I, Palacios IF., Retrograde versus antegrade percutaneous aortic balloon valvuloplasty: immediate, short- and long-term outcome at 2 years., Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 74, (2), 2009, p225-231
, Moyamoya disease with peripheral pulmonary artery stenoses and coronary artery fistulae., Case reports in medicine, 2009
Rodriguez, A.E., Maree, A., Tarragona, S., Fernandez-Pereira, C., Santaera, O., Rodriguez Granillo, A.M., Rodriguez-Granillo, G.A., Russo-Felssen, M., Kukreja, N., Antoniucci, D., Palacios, I.F., Serruys, P.W., Percutaneous coronary intervention with oral sirolimus and bare metal stents has comparable safety and efficacy totreatment with drug eluting stents, but with significant cost saving: Long-term follow-up results from the randomised, controlled ORAR III (Oral Rapamycin in ARgentina) study, EuroIntervention, 5, (2), 2009, p255-264
Patel, P.M., Eisenberg, J., Islam, M.A., Maree, A.O., Rosenfield, K.A., Percutaneous revascularization of persistent renal artery in-stent restenosis, Vascular Medicine, 14, (3), 2009, p259-264
, Non-coronary sinus of Valsalva aneurysm rupture., BMJ case reports, 2009
Jneid H, Cruz-Gonzalez I, Sanchez-Ledesma M, Maree AO, Cubeddu RJ, Leon ML, Rengifo-Moreno P, Otero JP, Inglessis I, Sanchez PL, Sanchez PL, Palacios IF., Impact of pre- and postprocedural mitral regurgitation on outcomes after percutaneous mitral valvuloplasty for mitral stenosis., The American journal of cardiology, 104, (8), 2009, p1122-1127
Cruz-Gonzalez I, Cubeddu RJ, Sanchez-Ledesma M, Cury RC, Coggins M, Maree AO, Palacios IF., Left atrial appendage exclusion using an Amplatzer device., International journal of cardiology, 134, (1), 2009, pe1-3
O'Halloran AM, Patterson CC, Horan P, Maree A, Curtin R, Stanton A, McKeown PP, Shields DC., Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2)., Journal of Thrombosis and Thrombolysis, 27, (2), 2009, p175 - 184
Islam, M.A., Rosenfield, K., Maree, A.O., Patel, P.M., Jaff, M.R., Percutaneous revascularization of occluded renal arteries in the setting of acute renal failure, Vascular Medicine, 14, (4), 2009, p365-369
Jneid, H., Maree, A.O., Palacios, I.F., Pericardial Tamponade: Clinical Presentation, Diagnosis, and Catheter-Based Therapies, Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 2008, p85-92
Jneid, H., Fonarow, G.C., Cannon, C.P., Hernandez, A.F., Palacios, I.F., Maree, A.O., Wells, Q., Bozkurt, B., LaBresh, K.A., Liang, L., Hong, Y., Newby, L.K., Fletcher, G., Peterson, E., Wexler, L., Sex differences in medical care and early death after acute myocardial infarction, Circulation, 118, (25), 2008, p2803-2810
Jneid, H., Maree, A.O., Palacios, I.F., Acute pericardial disease: Pericardiocentesis and percutaneous pericardiotomy, Acute Heart Failure, 2008, p255-265
Coronary Artery Perforation and Pericardial Intervention in, editor(s)David J. Moliterno; American College of Cardiology Foundation , CathSAP III Cardiac Catheterisation and Interventional Cardiology Self Assessment Program, 2008, pp23 - 31, [Andrew O. Maree, Vishal Gupta, Igor F. Palacios]
Meliga, E., Garcia-Garcia, H.M., Valgimigli, M., Chieffo, A., Biondi-Zoccai, G., Maree, A.O., Gonzalo, N., Cook, S., Cruz-Gonzalez, I., Marra, S., De Servi, S., Palacios, I.F., Windecker, S., Van Domburg, R., Colombo, A., Sheiban, I., Serruys, P.W., Diabetic patients treated for unprotected left main coronary artery disease with drug eluting stents: A 3-year clinical outcome study. The Diabetes and Drug Eluting stent for LeFT main registry (D-Delft), EuroIntervention, 4, (1), 2008, p77-83
Jneid, H., Fonarow, G.C., Cannon, C.P., Palacios, I.F., Kilic, T., Moukarbel, G.V., Maree, A.O., LaBresh, K.A., Liang, L., Newby, L.K., Fletcher, G., Wexler, L., Peterson, E., Impact of time of presentation on the care and outcomes of acute myocardial infarction, Circulation, 117, (19), 2008, p2502-2509
Sanchez-Ledesma M, Cruz-Gonzalez I, Sanchez PL, Sanchez PL, Martin-Moreiras J, Jneid H, Rengifo-Moreno P, Cubeddu RJ, Inglessis I, Maree AO, Palacios IF., Impact of concomitant aortic regurgitation on percutaneous mitral valvuloplasty: Immediate results, short-term, and long-term outcome., American heart journal, 156, (2), 2008, p361-366
Complications during Percutaneous Intervention in, editor(s)Ziyad M. Hijazi MD, MPH, Ted Feldman MD, John P Cheatham MD , Congenital and Structural heart Disease, 2008, pp101 - 109, [Andrew O. Maree, Igor F. Palacios]
, Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction., Journal of cellular and molecular medicine, 2008
Meliga E, Garcia-Garcia HM, Valgimigli M, Chieffo A, Biondi-Zoccai G, Maree AO, Cook S, Reardon L, Moretti C, De Servi S, Palacios IF, Windecker S, Colombo A, van Domburg R, Sheiban I, Serruys PW, DELFT (Drug Eluting stent for LeFT main) Registry., Longest available clinical outcomes after drug-eluting stent implantation for unprotected left main coronary artery disease: the DELFT (Drug Eluting stent for LeFT main) Registry., Journal of the American College of Cardiology, 51, (23), 2008, p2212-2219
Rodriguez, A.E., Maree, A.O., Palacios, I.F., Quality of life with PCI versus medical therapy in stable coronary disease [6], New England Journal of Medicine, 359, (21), 2008, p2290
Maree AO, Cox D, Fitzgerald DJ., Drug insight: aspirin resistance-fact or fashion?, Nature clinical practice. Cardiovascular medicine, 4, (3), 2007, pE1; author reply E2
Fitzgerald DJ, Maree A., Aspirin and clopidogrel resistance., Hematology. American Society of Hematology. Education Program, 2007, p114-120
Maree, A.O., Islam, M.A., Snuderl, M., Lamuraglia, G.M., Stone, J.R., Olmsted, K., Rosenfield, K.A., Jaff, M.R., External iliac artery endofibrosis in an amateur runner: Hemodynamic, angiographic, histopathological evaluation and percutaneous revascularization, Vascular Medicine, 12, (3), 2007, p203-206
Maree, A.O., Rosenfield, K.A., Endarterectomy versus stenting for carotid stenosis [3], New England Journal of Medicine, 356, (3), 2007, p306
Cruz-Gonzalez I, Martin-Herrero F, Gonzalez-Santos JM, Gutierrez-Diez JA, Sanchez-Ledesma M, Maree AO., Images in cardiovascular medicine. Anaphylaxis and recurrent hydatid disease., Circulation, 115, (25), 2007, pe643-5
Cruz-Gonzalez, I., Martin-Herrero, F., Gonzalez-Santos, J.M., Gutierrez-Diez, J.A., Sanchez-Ledesma, M., Maree, A.O., Anaphylaxis and recurrent hydatid disease, Circulation, 115, (25), 2007
, Non-coronary sinus of Valsalva aneurysm rupture., Heart (British Cardiac Society), 2007
Rodriguez AE, Maree AO, Mieres J, Berrocal D, Grinfeld L, Fernandez-Pereira C, Curotto V, Rodriguez-Granillo A, O'Neill W, Palacios IF., Late loss of early benefit from drug-eluting stents when compared with bare-metal stents and coronary artery bypass surgery: 3 years follow-up of the ERACI III registry., European heart journal, 28, (17), 2007, p2118-2125
, Acute pericardial disease, The Textbook Acute Heart Failure Syndromes., 2007
Dodd, J.D., Maree, A., Palacios, I., De Moor, M.M., Mooyaart, E.A.Q., Shapiro, M.D., Ferencik, M., Brady, T., Abbara, S., Cury, R.C., Hoffmann, U., Left main coronary artery compression syndrome: Evaluation with 64-slice cardiac multidetector computed tomography, Circulation, 115, (1), 2007
Maree AO, Jneid H, Palacios IF, Rosenfield K, MacRae CA, Fitzgerald DJ., Growth arrest specific gene (GAS) 6 modulates platelet thrombus formation and vascular wall homeostasis and represents an attractive drug target., Current pharmaceutical design, 13, (26), 2007, p2656-2661
Maree, A.O., Fitzgerald, D.J., Variable platelet response to aspirin and clopidogrel in atherothrombotic disease, Circulation, 115, (16), 2007, p2196-2207
Cox D, Maree AO, Dooley M, Conroy R, Byrne MF, Fitzgerald DJ., Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers., Stroke, 37, (8), 2006, p2153-2158
Maree AO, Jneid H, Fitzgerald DJ., Aspirin resistance and atherothrombotic disease., Journal of the American College of Cardiology, 48, (4), 2006, p846-7; author reply 847
Jneid H, Maree AO, Palacios IF., Drug-eluting stents in primary PCI., The New England journal of medicine, 355, (23), 2006, p2483-4; author reply 2484-6
Maree, A., Walsh, K., Coronary stent insertion into a 20-year-old Blalock-Taussig Shunt, Irish Medical Journal, 99, (7), 2006
Maree AO, Jneid H, Palacios IF., Percutaneous closure of a post-infarction ventricular septal defect that recurred after surgical repair., European heart journal, 27, (13), 2006, p1626
Pericardial Tamponade - Clinical Presentation, Diagnosis and Catheter-based Therapies in, editor(s)Joseph Parrillo R. Phillip Dellinger Imprint: Published Date: 12th November 2018 Page Count: 1346 , Critical Care Medicine: Principles of Diagnosis & Management in the Adult , Elsevier, 2006, pp85 - 92, [Jneid, H., Maree, A.O., Palacios, I.F.,]
Maree A, Palacios IF, Lago RM., Transcatheter closure of atrial septal defects in adults using two devices: an angiographic overview., Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 68, (6), 2006, p946-947
Levine GN, Berger PB, Cohen DJ, Maree AO, Rosenfield K, Wiggins BS, Spinler SA., Newer pharmacotherapy in patients undergoing percutaneous coronary interventions: a guide for pharmacists and other health care professionals., Pharmacotherapy, 26, (11), 2006, p1537-1556
Percutaneous Balloon Pericardiotomy for Patients with Pericardial Effusion and Tamponade in, editor(s)Debabrata Mukherjee; Leslie Cho; David J. Moliterno , Interventional Cardiology, 2006, pp262 - 269, [Andrew O. Maree, Hani Jneid, Igor F. Palacios]
Maree AO, Curtin RJ, Dooley M, Conroy RM, Crean P, Cox D, Fitzgerald DJ., Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease., Journal of the American College of Cardiology, 46, (7), 2005, p1258-1263
Maree AO, Curtin RJ, Chubb A, Dolan C, Cox D, O'Brien J, Crean P, Shields DC, Fitzgerald DJ., Cyclooxygenase-1 haplotype modulates platelet response to aspirin., Journal of thrombosis and haemostasis : JTH, 3, (10), 2005, p2340-2345
Maree AO, Cox D., Thrombosis and nitric oxide donor drugs., Thrombosis and haemostasis, 91, (5), 2004, p848-850
Maree AO, Fitzgerald DJ., Aspirin and coronary artery disease., Thrombosis and haemostasis, 92, (6), 2004, p1175-1181
Maree A, Fitzgerald DJ., Glycoprotein IIb/IIIa antagonists in acute coronary syndromes: where are we now?, Seminars in vascular medicine, 3, (4), 2003, p385-390
Maree A, Hillmann A, McRedmond J, Fitzgerald DJ., Homo sapiens growth arrest-specific 6 (GAS6) gene, exons 1 and 2 and partial, National Centre for Biotechnology Information. GenBank Submission (Accession No. AY170372) - 2002
Maree A, Fitzgerald D., PAR2 is partout and now in the heart., Circulation research, 90, (4), 2002, p366-368
Maree A, Fitzgerald D., Glycoprotein IIb/IIIa antagonists in acute coronary syndromes., Haematologica, 86, (11 suppl 2), 2001, p45-48
Mahon NG, Maree A, McKenna P, McCann HA, Sugrue DD., Emergency coronary angioplasty and stenting following acute myocardial infarction during pregnancy., The Journal of invasive cardiology, 11, (4), 1999, p233-236
Non-Peer-Reviewed Publications
JLaffan, A Foley, G Blake, A Maree, J Crowley, C McCreery, P Kearney, T Kiernan, M Kennedy, RA Byrne, Long-term survival in patients with ST-elevation myocardial infarction treated with timely PCI, delayed PCI, or a pharmaco-invasive strategy , Heart, Irish Cardiac Society Annual Scientific Meeting, Cork, Ireland , 6-8 October 2022, 108, (Suppl 3), BMJ Publishing Group Ltd and British Cardiovascular Society, 2022
MacAvin MJ, Maree AO, Barry M, Drug Induced QT Interval Prolongation, NMIC Bulletin, 2021
MacAvin MJ, Maree AO, Barry M, Drug Induced QT Interval Prolongation, Volume 21, 6, National Medicines Information Centre Bulletin, NIMC Bulletin, 2015
Maree A, Cardiac Rehabilitation and Secondary prevention, 8th World Congress of Cardiology; Published in Heartwise 7/'04, 2004
Maree A, Sugrue D, C.R.P and Statins for All, Irish Medical News., 2002
Maree A, Sugrue D, The evolving relationship of C-Reactive protein and coronary heart disease, Hospital Doctor and Modern Medicine., 2001
Research Expertise
Projects
- Title
- Heart Rate Recovery Velocity as a predictor of Morbidity in Moderate Aortic Stenosis
- Summary
- Introduction: Heart-rate recovery time between 10 and 20 seconds post-orthostatic challenge (HRRT10-20) correlates with all-cause mortality and is a direct marker of autonomic function (McCrory et al, Circ Res.2016). Preliminary analysis of patients with severe symptomatic aortic stenosis (AS) shows impaired HRRT10-20 in this cohort who have a very high untreated mortality. Moderate AS is also associated with increased mortality but current practice is to wait until patients develop symptoms or severe AS. Hypothesis: Patients with moderate AS will have evidence of autonomic dysfunction when compared to age and sex matched controls and a lesser degree of autonomic dysfunction than patients with severe AS. Increased autonomic dysfunction may identify those at highest risk who should be considered for earlier valve replacement. Methods: Active project prospectively comparing patients with moderate aortic stenosis with age and sex matched controls.
- Funding Agency
- Royal City of Dublin Hospital Trust
- Date From
- 07-2023
- Date To
- 06-2025
- Title
- Cardiovascular Autonomic Function and Response to Aortic Valve Replacement
- Summary
- We hypothesise that cardiovascular autonomic function improves following aortic valve replacement and represents a measurable predictor of procedural outcome and thereby mortality benefit. We also hypothesize that patients post transcatheter aortic valve implantation (TAVI) have comparable cardiovascular autonomic function outcomes to patients post surgical aortic valve replacement (SAVR). Ongoing research project with ethics approval and grant funding in place but pending completion therefore methodology withheld.
- Funding Agency
- Royal City of Dublin Hospital Trust
- Date From
- 08-2021
- Date To
- 07-2023
- Title
- Assessment of Speed of Heart Rate Recovery as a Modifiable Risk Factor Post Coronary Intervention and Cardiac Surgery
- Summary
- Ongoing research, enrolement completed and data analysis ongoing. Part published but final publication in preparation therefore methodology withheld.
- Funding Agency
- Royal City of Dublin Hospital Trust
- Date From
- 7/2019
- Date To
- 6/2021
- Title
- Novel Markers of Plaque Rupture in Patients with Chest Pain
- Summary
- Despite extensive research cardiovascular disease remains the leading cause of death in developed countries. Thus, its primary and secondary prevention remain a public health priority. Non-traumatic chest pain presentation to the accident and emergency department accounts for between 6-10% of patients' seen and management of these patients is challenging. An assay that detects patients with chest pain who are at risk of plaque rupture and in whom coronary thrombosis and myocardial injury have not yet occurred would provide for pre-emptive treatment and thereby also diminish the risk of progression to chronic cardiovascular disease would be extremely useful. This is the basis of our novel serum biomarker study. We will evaluate patients who present with chest pain and screen them for novel serum biomarkers of coronary plaque instability. We will also develop assays for measuring these proteins and ultimately develop a blood test that will identify patients at high risk of MI. The aim is that when a patient presents to A&E with chest pain a series of point of care serum marker assay will facilitate rapid stratification as cardiac or non-cardiac chest pain. This will allow for early treatment or discharge. We have been working with collaborators in Bristol who have developed a mouse model of atherosclerosis (Research Frontiers Programme funded by SFI). Using this ApoE mouse model of atherosclerosis and a protein array we have already identified a number of serum proteins (biomarkers) where changes in their levels predict plaque rupture. We collected serum from mice both before and after plaque rupture and analysed the levels of different proteins in the serum of these mice. Plaque rupture was determined by histological analysis of the brachiocephalic artery. We identified a number of novel proteins that were present at significantly high levels in the serum prior to plaque rupture and may be predictive of higher risk of rupture. A number of these proteins have never been shown to be associated with plaque rupture previously. Although we provided evidence that these serum proteins have the potential to act as biomarkers of plaque rupture we did so in an artificial animal model of plaque rupture and therefore needed to confirm that the same protein pattern occurred in humans. We therefore conducted a preliminary pilot study of 40 patients who presented with chest pain. We identified similar markers of plaque rupture in patients presenting with unstable angina. While these biomarker proteins were clearly expressed in mice we needed to confirm that the same proteins were expressed in humans. To achieve this we enrolled a small number of patients at Waterford Regional Hospital in 2013 and repeated the same protein biomarker assays confirming that these markers were present in human serum and detectable by ELISA.
- Funding Agency
- Royal City of Dublin Hospital Trust
- Date From
- 7/2014
- Date To
- 6/2017
- Title
- Platelet Proteome and Thromboxane Synthesis in Coronary Artery Disease
- Summary
- B) Proteomic Analysis Many types of CVD have a platelet component in their pathogenesis. These include atherosclerosis leading to coronary artery disease (platelet secretion contributes to atherosclerosis, thrombotic events leading to myocardial infarction (platelets are central to thrombosis); and potentially atrial fibrillation leading to stroke (there is evidence of platelet activation in atrial fibrillation that may contribute to thrombosis leading to embolism and stroke. For this arm of our study we hypothesize that biomarkers may be identified in platelet samples that are associated with risk of developing various forms of CVD, or with suboptimal responses to antithrombotic therapy (bleeding, or continued risk of thrombosis). Furthermore, it is hypothesised that these markers are present chronically, not just at the time of acute events, and could be used to diagnose disease or predict treatment response. Proteomics offers a way to transform how platelets are analysed by determining the composition of platelet proteins and their changes upon stimulation and in disease. Proteomics can be used to explore the differences in protein profiles between different cardiovascular disease (CVD) populations, using information from multiple proteins to identify shared features of patient groups. Such a 'signature' of disease may have several future applications. Firstly, it may ultimately be used in the prediction of outcomes in CVD. Secondly, it may be used to monitor treatments of CVD, to determine if treatment normalises the signature. Thirdly, variations in the signature may identify subcategories and stratifications in CVD populations, and may be used to determine the type and extent of treatment suitable for individual patients. As part of a research and development programme in platelet biomarkers, Java Clinical Research in University College Dublin (UCD) has developed a method to analyse platelet samples for protein markers that may predict risk of thrombosis and response to antiplatelet drugs. Platelets are an excellent source of biomarkers for this, since they play a role in many types of CVD, including atherogenesis, thrombosis and bleeding. Furthermore, platelets are readily sampled from peripheral blood, and Java has developed streamlined methods to process and analyse them for biomarkers that reflect the donor's status and the impact of genetic variation, disease and drug treatment. The study was withdrawn due to closure of the Java Clinical Research in University College Dublin (UCD) and inability to perform proteomic analysis shortly after funding awarded.
- Funding Agency
- Royal City of Dublin Hospital Trust
- Date From
- 2016
- Date To
- 2016
- Title
- (K123 HL083781). P I: Joseph A Vita: Boston University Medical Center Leadership Program in Vascular
- Funding Agency
- NIH
- Date From
- 2008
- Title
- Peripheral Arterial Vascular closure with Starclose Device.
- Summary
- Clinical trail of StarClose Device use in PAD patients
- Funding Agency
- Abbott Laboratories
- Date From
- 2006
- Date To
- 2007
- Title
- Aspirin responsiveness testing predicts bleeding during coronary artery bypass grafting: The Verify Pre-Op TIMI 45 Study
- Summary
- Introduction: Many patients receive aspirin prior to coronary artery bypass grafting (CABG), despite its association with perioperative bleeding and variable effectiveness among individuals. Hypothesis: We assessed the hypothesis that point-of-care aspirin responsiveness testing predicts bleeding and ischemic events during CABG. Methods: Verify Pre-Op [[Unable to Display Character: -]] TIMI 45 was a prospective study of 38 patients on aspirin who underwent CABG. VerifyNow Aspirin Reaction Units (ARU) (Accumetrics, San Diego, CA) were measured < 24 hours before CABG, with higher ARU indicating more reactive platelets. Endpoints were decrease in hemoglobin (Hgb) and hematocrit (HCT), platelet transfusion, major bleeding (≥ 5 red blood cell units transfused or > 2 L chest tube output), and myocardial infarction < 24 hours after surgery. Endpoints were analyzed by ARU tertiles, and the cut-point for the lowest tertile (ARU 412), reported as mean ± SD. Results: Mean ARU was 472 ± 85. There was less bleeding across tertiles of higher ARU (p=0.039 for Hgb; p=0.028 for HCT) (Figure). Decrease in Hgb was greater in patients with ARU < 412 (5.4 ± 2.3 g/dL v. 3.4 ± 2.0 g/dL, p=0.011). Decrease in HCT was also greater in those with ARU < 412 (16.3 ± 6.9% v. 10.2 ± 6.2%, p=0.008). As a continuous variable, higher platelet reactivity (ARU) correlated with less of a decrease in Hgb and HCT (Spearman r=0.422, p=0.008 for Hgb; r=0.426, p=0.008 for HCT). Patients with ARU < 412 were more likely to have at least one platelet transfusion (53.9% v. 8.7%, p=0.005), and more units transfused (2.3 ± 3.8 units v. 0.2 ± 0.6 units, p=0.003). Major bleeding was more frequent in those with ARU < 412 (25% v. 0%, p=0.026). There was no difference in myocardial infarction, though there were few events (n=3). Conclusion: Aspirin responsiveness testing predicts bleeding in patients exposed to aspirin undergoing CABG. An ARU ≥ 412 was predictive of less bleeding, less need for platelet transfusion, and was not associated with increased ischemic risk.
- Funding Agency
- Accumetrics Inc
- Date From
- 2006
- Date To
- 2007
- Title
- Genetics of GAS6: A Novel Target in Coronary Thrombosis and Atherosclerosis.
- Summary
- Since 2001 I have been investigating the impact of platelet genetic variation on signal transduction and drug response. GAS6 is implicated in vascular remodelling, inflammation and atherothrombosis and is a novel antiplatelet drug target (Maree et al., 2007 Curr Pharm Des.) (Maree et al., 2002 GAS6 Nucleotide Sequence (AY170372) EMBL/GenBank/DDBJ databases). This work was performed in collaboration with Prof Desmond Fitzgerald and Prof Denis Shields and was supported by grants from the Irish Heart Foundation and the Higher Education Authority, Ireland.
- Funding Agency
- Irish Heart Foundation
- Date From
- 2001
- Date To
- 2004
- Title
- "The effect of Genetic Variation and Platelet Receptor expression on the Antiplatelet response to Aspirin."
- Summary
- Abstract Background: Serotonin (5-HT) induces platelet aggregation by activating its 5-HT2A receptor. Platelet uptake is mediated by the 5-HT transporter (5-HTT). A common 5-HTT promoter (5-HTTLPR) splice variant results in long (L) and short (S) alleles. 5-HTTLPR genotype has been associated with increased platelet activation and risk of MI. Variation within HTR2A gene (C1354T) that encodes the 5-HT2A receptor has also been associated with enhanced platelet aggregation. We hypothesised that 5-HTT and/or HTR2A variation may influence platelet response to aspirin in patients with stable CAD. Methods: Patients (n=144) with stable cardiovascular disease taking aspirin were genotyped for the 5-HTTLPR and HTR2A variants. Platelet inhibition was assessed by serum thromboxane and arachidonic acid-induced platelet aggregation assay. Results: 5-HTT genotype (LL vs *S) was a significant determinant of serum TX level (8.9±2.6ng/ml vs 6.0±1.6ng/ml respectively; p<0.02) and 5-HTT LL genotype predicted an incomplete aspirin response (serum TXB2>2.2ng/ml) (p=0.04; OR=2.22, CI=1.03-4.79). Odds ratio of the effect of LL genotype on TX elevation was 3.8 (95% CI 1.2-11.6) in younger patients (under 64) compared to 1.0 (95% CI=0.3-3.8) in older subjects. LL genotype did not influence AA aggregation (p=0.83, OR=1.2, CI=0.3-4.1). The HTR2A variant had no effect on TX generation (p=0.70; OR=1.22, CI=0.45-3.26) nor AA aggregation (p=0.99; OR=1.0, CI=0.2-4.9). Conclusions: In younger patients with stable CAD 5HTT LL genotype carried by almost one third of our cohort is associated with a diminished response to aspirin that may increase cardiovascular risk. Genotypic variation in platelet activation may be a contributing mechanism. Keywords: Aspirin; Coronary disease; Genetic; Serotonin.
- Funding Agency
- Irish Heart Foundation Research Grant
- Date From
- 2002
- Date To
- 2004
- Title
- "The effect of Genetic Variation and Platelet Receptor expression on the Antiplatelet response to Aspirin."
- Funding Agency
- Irish Heart Foundation Research Grant
- Date From
- 2002
- Date To
- 2004
Recognition
Representations
Session Co-chair American College of Cardiology Annual Scientific Sessions Meeting
Invited Panelist American College of Cardiology Annual Scientific Meeting. Caring for the Patient with STEMI in 2021
National Office of Clinical Audit: Members of the ACS Audit Governance Committee
American Heart Association Annual Scientific Meeting. Invited Faculty
International Meeting on Structural Heart Disease Intervention. Salamanca, Spain. Invited Faculty
Board Member Irish Heart Foundation
The CoMPPAS Career Development Advisory Forum: The Royal College of Surgeons in Ireland
2009- National Acute Coronary Syndrome Program committee
2012 - Treasurer Irish Cardiac Society
2013- Member RCPI Policy Group on Obesity
Dublin Midlands Hospital Network Clinical lead, National ACS programme
Awards and Honours
American College of Cardiology Annual Scientific Meeting, Young Investigator Award (Physiology, Pathology, Pharmacology)
European Society of Cardiology Annual Scientific Meeting, Young Investigator Award in Thrombosis
European Society of Cardiology Annual Scientific Meeting, Young Investigator Award in Thrombosis (Non-presenting co-primary investigator)
American Heart Association, second author on winning Laennec Clinical Case Competition
Irish Association of Internal Medicine "Brian Lemass" Gold Medal for research
Irish Board for Training in Cardiovascular Medicine Specialist Registrar in Cardiology Research Prize
Irish Cardiac Society Young Investigator Medal
Royal College of Physicians of Ireland "William Stokes Award" for Research
Irish Association of Internal Medicine "Brian Lemass" Gold Medal for research
Irish Board for Training in Cardiovascular Medicine / Bristol-Myers Squibb College Inaugural Travelling Fellowship
Irish Cardiac Society, 1st Placed Moderated Poster
Beaumont Hospital Sheppard Prize - 1st placed research poster presentation
Distinctions in Final examinations - Medicine/Surgery/Paediatrics/Obstetrics/Gynaecology/ Ophthalmology honours.
Memberships
Collegiate Member Royal College of Physicians in Ireland
Member of the American Heart Association, Council on Atherosclerosis, Thrombosis and Vascular Biology
Member AHA Interdisciplinary working group in Functional Genomics and Translational Biology.
2004 - Member of the European Society of Cardiology
Member of the Irish Cardiac Society
Member of the American College of Cardiology
Fellow of the American Heart Association
Fellow of the Royal College of Physicians in Ireland
Treasurer Irish Cardiac Society
Board Member Irish Heart Foundation