Dr. Dominic Trepel
Assistant Professor, Psychiatry
Assistant Professor, Trinity Inst. of Neurosciences (TCIN)
Biography
Dominic Trépel (PhD) joined Trinity in 2017 as an Assistant Professor of Economics and is jointly appointed as faculty for the Global Brain Health Institute (www.gbhi.org) and Trinity School of Medicine. Trépel is also primary investigator in Trinity College Institute of Neuroscience (TCIN) where he directs Trépel lab (www.healtheconomics.ie). Trépel has been an academic health economics for over 15 years, has published over 100 research articles and much of this research efforts are dedicated to the study of dementia, brain health and ageing. Trépel lab currently includes ten PhDs and Postdoctoral researchers working on grants funded by: Health Research Board (HRB), Irish Research Council (Ireland), Research Collaborative in Quality and Patient Safety (RCQPS), Health and Social Care Northern Ireland (R&D Division), Global Brain Health Institute, Brainlat and National Health and Medical Research Council (NHMRC).
Trépel has previously held Senior Research Fellowships with leading centres in health economics including University of York and the Academic Unit for Health Economics (AUHE) at University of Leeds. His PhD examined the 'Economics of Dementia in Ireland and Europe' was supported by the prestigious Government of Ireland Scholarship (IRCHSS) and a Cochrane Fellowship (HRB), and outputs were presented to members of the Irish Parliament.
Trépel is a member of the International Health Economics Association (iHEA), and the Campbell and Cochrane Economics Methods Group (CCEMG). He was part of the scientific committee for the joint meeting of the Coèllge des Economistes de la Santé (CES) and the Health Economists' Study Group (HESG). He also serves on the Editorial Board for Alzheimer's and Dementia Journal, is an associate editor for Frontiers in Health Services and further peer-reviews research for, amongst others the Health Economics Journal, Social Science in Medicine, National Institute for Health Research (NIHR) Library. Trépel has also reviewed research funding applications for NIHR, Medical Research Council (MRC), GBHI Pilot program, US Alzheimer's Association and the EU Joint Programme " Neurodegenerative Disease Research (JPND). Trépel also serves on the management committee of "Dementia Research Network Ireland".
Through his international doctoral training in health economics (from the Swiss School of Public Health (SSPH+)) and from working in a number of leading research centres, Trepél offers a broad technical skillset which includes: Applied Microeconometrics, Statistical Analysis, Health Service Research, Research Design, Economic Evaluation, Cost-Effectiveness Analysis, Health Technology Assessment, Randomised Control Trials, Decision-Analytic Modelling, Health Financing, Analysis of Health Expenditures, Critical Appraisal of Decision Models, Evidence Based Medicine, Systematic Review, Meta-analysis, Medical Decision Making, Outcomes Research, Reimbursement Mechanisms and Productivity Analysis.
Publications and Further Research Outputs
Peer-Reviewed Publications
Mostert, Cyprian M and Nesic, Olivera and Udeh-Momoh, Chi and Khan, Murad and Thesen, Thomas and Bosire, Edna and Trepel, Dominic and Blackmon, Karen and Kumar, Manasi and Merali, Zul, Who should pay the bill for the mental health crisis in Africa?, Public Health in Practice, 7, 2024
Edwards, S. and Trepel, D. and Ritchie, C. and Hahn-Pedersen, J. H. and Robinson, D. E. and Chan, M. S. and Bray, B. D. and Clark, A. and Ivkovic, M. and Michalak, W. and Wichmann, C. A. and Evans, M., Real world outcomes, healthcare utilisation and costs of Alzheimer's disease in England, Aging and Health Research, 4, (1), 2024, p100180
Brogaard, Niels Juul and Hahn-Pedersen, Julie Hviid and Gundgaard, Jens and Polavieja, Pepa and Bray, Benjamin D and Chan, Mei Sum and Hoang, Men and Araya, Daniel and Trepel, Dominic, Mapping between the Mini-Mental State Examination and the Clinical Dementia Rating scale for Patients with Alzheimer's disease: An External Validation Study, Alzheimer's Association International Conference, Alzheimer's Association International Conference, Krakow, Poland, 24-26 April 2024, ALZ, 2024
Dominic Trépel, Manuel Ruiz-Adame, Marica Cassarino, Elayne Ahern, Collette Devlin, Katie Robinson, Íde O'Shaughnessy, Gerard McCarthy, Cian Corcoran, Rose Galvin, The cost effectiveness of early assessment and intervention by a dedicated health and social care professional team for older adults in the emergency department compared to treatment-as-usual: Economic evaluation of the OPTI-MEND trial, PloS one, 19, (6), 2024, pe0298162
Iracema Leroi, Helena Dolphin, Rachel Dinh, Tony Foley, Sean Kennelly, Irina Kinchin, Rónán O'Caoimh, Sean O'Dowd, Laura O'Philbin, Susan O'Reilly, Dominic Trepel & Suzanne Timmons, Navigating the future of Alzheimer's Care in Ireland-a service model for disease-modifying therapies in small and medium-sized healthcare systems, BMC Health Services Research, 24, (1), 2024, p705
Edwards, Sophie and Trepel, Dominic and Ritchie, Craig W and Hahn-Pedersen, Julie Hviid and Chan, Mei Sum and Bray, Benjamin D and Clark, Alice and Wichmann, Christian Ahmad and Evans, Marc, Characterising subpopulations of patients with Alzheimer's disease dementia who have high healthcare utilisation and costs, Alzheimer's Association International Conference, Alzheimer's Association International Conference, Philadelphia, USA, July 28-Aug. 1, 2024, ALZ, 2024
Verma, Aparna and Saha, Sanjib and Jarl, Johan and Conlon, Ellen and McGuinness, Bernadette and Trépel, Dominic, An overview of systematic reviews and meta-analyses on the effect of medication interventions targeting polypharmacy for frail older adults, Journal of Clinical Medicine, 12, (4), 2023, p1379
Comans, Tracy and Nguyen, Kim and Gray, Len and Flicker, Leon and Williamson, Paula and Dodd, Susanna and Kearney, Anna and Cunningham, Colm and Morris, Thomas and Nunn, Jack, Measuring the success of programmes of care for people living with dementia: a protocol for consensus building with consumers to develop a set of Core Outcome Measures for Improving Care (COM-IC), BMJ open, 13, (12), 2023, pe073884
Nguyen, Kim Huong, Comans, Tracy, Saha, Sanjib and Trepel, Dominic, Core outcome set for economic evaluation of dementia interventions: A consensus exercise with health economists who incorporate economic evaluations into dementia trial, 19, 2023, ppe080163
Trepel, D and Edwards, S and Ritchie, C and Hahn-Pedersen, JH and Kettle, J and Chan, MS and Bray, BD and Clark, A and Ivkovic, M and Wichmann, CA, MSR71 Projecting the Potential Impact of Disease Modifying Therapy on the Future Health and Social Costs of Alzheimer's disease, Value in Health, 26, (12), 2023, pS406
Mairéad Conneely, Aoife Leahy, Margaret O'Connor, Louise Barry, Gillian Corey, Anne Griffin, Íde O'Shaughnessy, Ida O'Carroll, Siobhán Leahy, Dominic Trépel, Damian Ryan, Katie Robinson & Rose Galvin, A physiotherapy-led transition to home intervention for older adults following emergency department discharge: a pilot feasibility randomised controlled trial (ED PLUS), Clinical Interventions in Aging, 2023, p1769-1788
Rogan, Carol and Rock, Bernadette and Begley, Emer and Boland, Barry and Brazil, Kevin and Diaz-Orueta, Unai and Donnelly, Sarah and Foley, Michael and Foley, Tony and Hannigan, Caoimhe, Dementia research in Ireland: What should we prioritise?, HRB Open Research, 6, 2023
Ruiz-Adame, M., Ibanez, A., Mollayeva, T. and Trépel, D., Association Between Neuroticism and Dementia on Healthcare Use: A Multi-Level Analysis Across 27 Countries from The Survey of Health, Ageing and Retirement in Europe (SHARE), Journal of Alzheimers Disease, 95, (1), 2023, p181-193
Lyons, Shane and Trépel, Dominic and Lynch, Tim and Walsh, Richard and O'Dowd, Sean, The prevalence and incidence of progressive supranuclear palsy and corticobasal syndrome: a systematic review and meta-analysis, Journal of Neurology, 270, (9), 2023, p1-15
Seghers P. A. L, Alibhai Shabbir M. H, Battisti Nicolò Matteo Luc, Kanesvaran Ravindra, Extermann Martin, O' Donovan Anita, Pilleron Sophi, Mislang Anna Rachell, Musolino Naji, Cheung Kwok-Leun, Staines Anthon, Girvalaki Chari, Soubeyran Pierr, Portielje Johanneke E. A, Rostoft Sir, Hamaker Marije E, Trépel Dominic, O'Hanlon Shan, Geriatric assessment for older people with cancer: policy recommendations, Global Health Research and Policy, 8, (1), 2023, p37-
Kenney, D., Comans, T., Nguyen, K., Gray, L., Flicker, L., Williamson, P, Dodd,S, Kearney, A, Cunningham,C, Morris, T, Nunn, J, Trepel, D, Almeida, O, Welch,A, Lowthian, J, Quinn, J, Petrie, G, Dao-Tran, T-H, Manchha, A, and Kurrle, S, Ethical considerations for participatory action research involving people with potential cognitive impairment, Alzheimer's and Dementia, Alzheimer's Association International Conference 2023, Amsterdam, Netherlands, 16-20 July 2023, 19, 2023, ppe073876
Corcoran, Cian and Ruiz-Adame, Manuel and Trépel, Dominic, Early assessment and intervention by a dedicated health and social care professional team in the emergency department in older adults compared to treatment-as-usual: Health Economic Analysis Plan for within-trial cost effectiveness analysis, HRB Open Research, 6, (22), 2023, p22
Conneely, M and Leahy, S and Trépel, D and Robinson, K and Boland, F and Moriarty, F and Galvin, R, 1298 The Impact of Acute Healthcare Utilisation on Functional Decline in Older Adults over Time: A Population-Based Cohort Study, 52, (Supplement_1), 2023, ppafac322. 046
Conneely, Mairead, Leahy, Aoife, O'Connor, Margaret, Barry, Louise, Corey, Gillian, Griffin, Anne, O'Shaughnessy, Íde. O'Carroll, Ida, Leahy, Siobhán, Trepel, Dominic, Ryan, Damian; Robinson, Katie, Galvin, Rose, A physiotherapy-led transition to home intervention for older adults following emergency department discharge: protocol for a pilot feasibility randomised controlled trial, Pilot and feasibility studies, 8, (1), 2022, p1--14
Mitchell, Eileen and Ahern, Elayne and Saha, Sanjib and McGettrick, Grainne and Trepel, Dominic, The Value of Nonpharmacological Interventions for People With an Acquired Brain Injury: A Systematic Review of Economic Evaluations, Value in Health, 2022, p10.1016/j.jval.2022.03.014
Saldanha, Ian J and Dodd, Susanna and Fish, Rebecca and Gorst, Sarah L and Hall, Deborah A and Jacobsen, Pamela and Kirkham, Jamie J and Trepel, Dominic and Williamson, Paula R, Comparison of published core outcome sets with outcomes recommended in regulatory guidance from the US Food and Drug Administration and European Medicines Agency: cross sectional analysis, BMJ Medicine, 1, (1), 2022
Conneely, M and Leahy, S and Dore, L and Trépel, D and Robinson, K and Jordan, F and Galvin, R, 1075 The Effectiveness of Interventions to Reduce Adverse Outcomes Among Older Adults Following Emergency Department Discharge, 51, (Supplement_2), 2022, ppafac126. 082
Kinchin, Irina and Edwards, Layla and Hosie, Annmarie and Agar, Meera and Mitchell, Eileen and Trepel, Dominic, Cost-effectiveness of clinical interventions for delirium: A systematic literature review of economic evaluations, Acta Psychiatrica Scandinavica, 2022
Persson, Sofie and Saha, Sanjib and Gerdtham, Ulf-G and Toresson, Hakan, Healthcare costs of dementia diseases before, during and after diagnosis: Longitudinal analysis of 17 years of Swedish register data, Alzheimer's & Dementia, 2022
Mairéad Conneely, Siobhán Leahy, Dominic Trépel, Katie Robinson, Fiona Boland, Frank Moriarty, Rose Galvin, Is there evidence of an association between acute healthcare utilisation and function in older adults over time? A Population-Based Cohort Study, Innovation in Aging, 2022
Ritchie, CW and Waymont, JMJ and Pennington, C and Draper, K and Borthwick, A and Fullerton, N and Chantler, M and Porteous, ME and Danso, SO and Green, A and others, The Scottish Brain Health Service Model, The Journal of Prevention of Alzheimer's Disease volume, 2022
Conneely, Mairead, Leahy, Siobhan, Dore, Liz, Trépel, Dominic, Robinson, Katie, Jordan, Fionnuala, & Galvin, Rose, The effectiveness of interventions to reduce adverse outcomes among older adults following Emergency Department discharge: umbrella review, BMC geriatrics, 22, (1), 2022, p1--23
Conneely, M and Holmes, A and O'Connor, M and Leahy, A and Gabr, A and Saleh, A and Okpaje, B and Corey, G and Barry, L and Griffin, A and others, 265 A PHYSIOTHERAPY-LED TRANSITION TO HOME INTERVENTION FOR OLDER ADULTS FOLLOWING EMERGENCY DEPARTMENT DISCHARGE: A PILOT FEASIBILITY RANDOMISED-CONTROLLED TRIAL, 51, (Supplement_3), 2022, ppafac218--233
Trépel, Dominic, A Compendium of Two Decades of Economic Evaluations in Dementia and a Critique of the Implied Use of Resources, Alzheimer's Association International Conference, AAIC 2022, 2022
Kinchin, I., Mitchell, E., Agar, M., Trépel, D., The economic cost of delirium: A systematic review and quality assessment, Alzheimer's & Dementia, 2021
Mitchell, Eileen and Saha, Sanjib and Conlon, Ellen and Walshe, Fiona and MacGearail, Finn and Mockler, David and Trépel, Dominic, An overview of systematic reviews for older people who become frail, 2021
Forster, Anne and Godfrey, Mary and Green, John and McMaster, Nicola and Airlie, Jennifer and Cundill, Bonnie and Lawton, Rebecca and Hawkins, Rebecca and Hulme, Claire and Birch, Karen and others, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, 2021
Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trépel D, Ibanez A., Dementia in Latin America: Paving the way toward a regional action plan, Alzheimer's & Dementia, 2021
John Cullinan, Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding, Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE), Medicina, 57, (3), 2021, p208
Rentz DM, Wessels AM, Annapragada AV, Berger AK, Edgar CJ, Gold M, Miller DS, Randolph C, Ryan JM, Wunderlich G, Zoschg MC, Trépel D, Knopman DS, Staffaroni AM, Bain LJ, Carrillo MC, Weber CJ., Building clinically relevant outcomes across the Alzheimer's disease spectrum., Alzheimer's & dementia (New York, N. Y.), 7, (1), 2021, pe12181
Ritchie, Craig W and Waymont, Jennifer MJ and Pennington, Catherine and Draper, Kristy and Borthwick, Anna and Fullerton, Neil and Chantler, M and Porteous, Mary E and Danso, SO and Green, Alison and others, The Scottish Brain Health Service Model: Rationale and Scientific Basis for a National Care Pathway of Brain Health Services in Scotland, The Journal of Prevention of Alzheimer's Disease, 2021, p1--11
M. Cochrane, E. Mitchell, W. Hollingworth, E. Crawley, D. Trépel, Cost-effectiveness of Interventions for Chronic Fatigue Syndrome or Myalgic Encephalomyelitis: A Systematic Review of Economic Evaluations, Applied Health Economics and Health Policy, 2021
Phillips, Nicola and Ahern, Elayne and Mockler, David and McGettrick, Grainne and Fitzpatrick, Kyle and Trépel, Dominic, The Effectiveness of Community Neurorehabilitation for Persons with an Acquired Brain Injury: Protocol for a Systematic Review and Meta-Analysis, 2021
Bell, Phaedra and Allen, Isabel Elaine and Vega, Yvette and Lanata, Serggio and Power, Joanna McHugh and Trepel, Dominic and Perissinotto, Carla and Yaffe, Kristine and Miller, Bruce L and Lawlor, Brian, Effects of COVID-19 Adaptations for Older Participants in Multimodal Intergenerational Social Contact Intervention for Creative Engagement (MISCI-CE), 2021 Alzheimer's Association International Conference, 2021
Mairéad Conneely, Katie Robinson, Siobhán Leahy, Dominic Trépel, Fionnuala Jordan, Rose Galvin, Effectiveness of interventions to reduce adverse outcomes among older adults following emergency department discharge: Protocol for an overview of systematic reviews, HRB Open Research, 2021
Eileen Mitchell, Elayne Ahern, Sanjib Saha, Dominic Trepel, Neuropsychological rehabilitation interventions for people with an acquired brain injury. A protocol for a systematic review of economic evaluation, HRB Open Research, 2020
Mairéad Conneely, Pauline Boland, Aoife O'Neill, David Byrne, Sinéad Cronin, Dominic Quinn, Dominic Trépel, Siobhán Leahy, Jon Salsberg, Rose Galvin, Katie Robinson, A protocol for the establishment and evaluation of an older adult stakeholder panel for health services research, HRB Open Research, 3, 2020, p1
Derek Pheby, Diana Arleaaja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig Hughes, Rachael Hunter, Dominic Trepel, Xia Wang-Steverding, A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE), Healthcare, 2020
Derek F.H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A Hughes, Rachael M Hunter, Dominic Trepel, Xia Wang-Steverding, The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE), Healthcare, 8, (2), 2020, p88
Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding, A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE), Medicina, 57, (1), 2020, p7
Dominic Trépel, Shehzad Ali, Simon Gilbody, Alfonso Leiva, Dean Mcmillan, Ferran Bejarano, Ermengol Sempere, Caterina Vicens, Cost-effectiveness of brief structured interventions to discontinue long-term benzodiazepine use: an economic analysis alongside a randomised controlled trial, HRB Open Research, 3, 2020, p33
McRobbie, H., Hajek, P., Peerbux, S., Kahan, B.C., Eldridge, S., Trépel, D., Parrott, S., Griffiths, C., Snuggs, S., Smith, K.M., Randomised controlled trial and economic evaluation of a task-based weight management group programme, BMC Public Health, 19, (1), 2019
Walsh, D., Belton, S., Meegan, S., Bowers, K., Corby, D., Staines, A., McVeigh, T., McKeon, M., Hoey, E., Trépel, D., Griffin, P., Sweeney, M.R., A comparison of physical activity, physical fitness levels, BMI and blood pressure of adults with intellectual disability, who do and do not take part in Special Olympics Ireland programmes: Results from the SOPHIE study, Journal of Intellectual Disabilities, 22, (2), 2018, p154-170
Graham, L., Cicero, R., Clarke, D., Cundill, B., Ellwood, A., Farrin, A., Fisher, J., Goodwin, M., Hawkins, R., Hull, K., Hulme, C., Trépel, D., Williams, R., Forster, A., PATCH: Posture and mobility training for care staff versus usual care in care homes: Study protocol for a randomised controlled trial 11 Medical and Health Sciences 1117 Public Health and Health Services, Trials, 19, (1), 2018
The economics of preventing dementia in, editor(s)Kate Irving, Eef Hogervorst, Deborah Oliveira, Miia Kivipelto , New Developments in Dementia Prevention Research: State of the Art and Future Possibilities, Routledge, 2018, pp156 - 169, [Trepel]
White, P.C.L., Wyatt, J., Chalfont, G., Bland, J.M., Neale, C., Trepel, D., Graham, H., Exposure to nature gardens has time-dependent associations with mood improvements for people with mid- and late-stage dementia: Innovative practice, Dementia, 17, (5), 2018, p627-634
Simon Gilbody, Helen Lewis, Joy Adamson, Katie Atherton, Della Bailey, Jacqueline Birtwistle, Katharine Bosanquet, Emily Clare, Jaime Delgadillo, David Ekers, Deborah Foster, Rhian Gabe, Samantha Gascoyne, Lesley Haley, Jahnese Hamilton, Rebecca Hargate, Catherine Hewitt, John Holmes, Ada Keding, Amanda Lilley-Kelly, Shaista Meer, Natasha Mitchell, Karen Overend, Madeline Pasterfield, Jodi Pervin, David A. Richards, Karen Spilsbury, Gemma Traviss-Turner, Dominic Trépel, Rebecca Woodhouse, Friederike Ziegler, Dean McMillan, Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial, JAMA, 2017
Wright, B., Tindall, L., Littlewood, E., Allgar, V., Abeles, P., Trépel, D., Ali, S., Computerised cognitive-behavioural therapy for depression in adolescents: Feasibility results and 4-month outcomes of a UK randomised controlled trial, BMJ Open, 7, (1), 2017
Poston, Lucilla and Bell, Ruth and Briley, Annette L and Godfrey, Keith M and Nelson, Scott M and Oteng-Ntim, Eugene and Sandall, Jane and Sanders, Thomas AB and Sattar, Naveed and Seed, Paul T and others, The UK Pregnancies Better Eating and Activity trial: phase 3--randomised controlled trial, NIHR Journals Library, 2017
Bosanquet, K., Adamson, J., Atherton, K., Bailey, D., Baxter, C., Beresford-Dent, J., Birtwistle, J., Chew-Graham, C., Clare, E., Delgadillo, J., Ekers, D., Foster, D., Gabe, R., Gascoyne, S., Haley, L., Hamilton, J., Hargate, R., Hewitt, C., Holmes, J., Keding, A., Lewis, H., McMillan, D., Meer, S., Mitchell, N., Nutbrown, S., Overend, K., Parrott, S., Pervin, J., Richards, D.A., Spilsbury, K., Torgerson, D., Traviss-Turner, G., Trépel, D., Woodhouse, R., Gilbody, S., Collaborative care for screen-positive elders with major depression (CASPER plus): A multicentred randomized controlled trial of clinical effectiveness and cost-effectiveness, Health Technology Assessment, 21, (67), 2017, p1-251
Lewis, H., Adamson, J., Atherton, K., Bailey, D., Birtwistle, J., Bosanquet, K., Clare, E., Delgadillo, J., Ekers, D., Foster, D., Gabe, R., Gascoyne, S., Haley, L., Hargate, R., Hewitt, C., Holmes, J., Keding, A., Lilley-Kelly, A., Maya, J., McMillan, D., Meer, S., Meredith, J., Mitchell, N., Nutbrown, S., Overend, K., Pasterfield, M., Richards, D., Spilsbury, K., Torgerson, D., Traviss-Turner, G., Trépel, D., Woodhouse, R., Ziegler, F., Gilbody, S., Collaborative care and active surveillance for screen-positive EldeRs with subthreshold depression (CASPER): A multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness, Health Technology Assessment, 21, (8), 2017, p1-196
Hull, K and Forster, A and Farrin, A and Hulme, C and Fisher, J and Ellwood, A and Graham, L and Goodwin, M and Cicero, R and Trepel, D and others, From seed to sampling: growing the evidence, Physiotherapy, 103, 2017, pe124--e125
Cost-effectiveness of interventions for the treatment of dementia disorders in, Mental Health Economics, 2017, pp339-352 , [Trépel, D.]
Plummer F, Manea L, Trepel D, McMillan D., Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis., General hospital psychiatry, 39, 2016, p24-31
David Marshall, Barry Wright, Victoria Allgar, Joy Adamson, Christine Williams, Hannah Ainsworth, Liz Cook, Danielle Varley, Lisa Hackney, Paul Dempster, Shehzad Ali, Dominic Trepel, Danielle Collingridge Moore, Elizabeth Littlewood, Dean McMillan, Social Stories in mainstream schools for children with autism spectrum disorder: a feasibility randomised controlled trial, BMJ Open, 6, (8), 2016
Amanda Perry, Rebecca Woodhouse, Matthew Neilson, Marrissa Martyn St James, Julie Glanville, Catherine Hewitt, Dominic Trépel, Are Non-Pharmacological Interventions Effective in Reducing Drug Use and Criminality? A Systematic and Meta-Analytical Review with an Economic Appraisal of These Interventions, International Journal of Environmental Research and Public Health, 13, (10), 2016, p966
McRobbie, H., Hajek, P., Peerbux, S., Kahan, B.C., Eldridge, S., Trépel, D., Parrott, S., Griffiths, C., Snuggs, S., Smith, K.M., Tackling obesity in areas of high social deprivation: Clinical effectiveness and cost-effectiveness of a task-based weight management group programme " A randomised controlled trial and economic evaluation, Health Technology Assessment, 20, (79), 2016
Overend, K., Lewis, H., Bailey, D., Bosanquet, K., Chew-Graham, C., Ekers, D., Gascoyne, S., Hems, D., Holmes, J., Keding, A., McMillan, D., Meer, S., Meredith, J., Mitchell, N., Nutbrown, S., Parrott, S., Richards, D., Traviss, G., Trépel, D., Woodhouse, R., Gilbody, S., Erratum to: CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): Study protocol for a randomised controlled trial. [Trials. (2014), 15, 451.], Trials, 17, (1), 2016
Staines, Anthony and Walsh, Denise and Corby, Deirdre and Bowers, Kirsty and Belton, Sarahjane and McVeigh, Treasa and McKeon, Michael and Trepel, Dominic and Griffin, Peter and Sweeney, Mary Rose, Edel Hoey, Journal of Intellectual Disabilities, 1, 2016, p20
McRobbie, H., Hajek, P., Peerbux, S., Kahan, B.C., Eldridge, S., Trépel, D., Parrott, S., Griffiths, C., Snuggs, S., Myers Smith, K., Tackling obesity in areas of high social deprivation: clinical effectiveness and cost-effectiveness of a task-based weight management group programme - a randomised controlled trial and economic evaluation, Health technology assessment (Winchester, England), 20, (79), 2016, p1-150
Arri Coomarasamy, Helen Williams, Ewa Truchanowicz, Paul T Seed, Rachel Small, Siobhan Quenby, Pratima Gupta, Feroza Dawood, Yvonne E Koot, Ruth Bender Atik, Kitty WM Bloemenkamp, Rebecca Brady, Annette Briley, Rebecca Cavallaro, Ying C Cheong, Justin Chu, Abey Eapen, Holly Essex, Ayman Ewies, Annemieke Hoek, Eugenie M Kaaijk, Carolien A Koks, Tin-Chiu Li, Marjory MacLean, Ben W Mol, Judith Moore, Steve Parrott, Jackie A Ross, Lisa Sharpe, Jane Stewart, Dominic Trépel, Nirmala Vaithilingam, Roy G Farquharson, Mark David Kilby, Yacoub Khalaf, Mariëtte Goddijn, Lesley Regan, Rajendra Rai., PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation., Health technology assessment (Winchester, England), 2016
Wright, Barry and Marshall, David and Adamson, Joy and Ainsworth, Hannah and Ali, Shehzad and Allgar, Victoria and Moore, Danielle Collingridge and Cook, Elizabeth and Dempster, Paul and Hackney, Lisa and others, Qualitative analysis of the views of Social Story users, Health Technology Assessment, 2016
Edel Hoey Anthony Staines Denise Walsh Deirdre Corby Kirsty Bowers Sarahjane Belton Sarah Meegan Treasa McVeigh Michael McKeon Dominic Trépel Peter Griffin Mary Rose Sweeney, An examination of the nutritional intake and anthropometric status of individuals with intellectual disabilities: Results from the SOPHIE study, Journal of Intellectual Disabilities, 2016
Richardson, Rachel and Trepel, Cost-effectiveness of methods to identify and treat mental health difficulties in young people who have offended, 2015
Melvin, Cathie and Miller, Vivien and Slade, Pauline and Spiby, Helen and Trepel, Dominic and Weeks, Andrew and Whorwell, Peter and Williamson, Maria, The feasibility and acceptability of using the Mother-Generated Index (MGI) as a Patient Reported Outcome Measure in a randomised controlled trial of maternity care, 2015
Kirsty Bowers Deidre Corby Veronica Lambert Anthony Staines Treasa McVeigh Michael McKeon Edel Hoey Sarahjane Belton Sarah Meegan Denise Walsh Dominic Trépel Peter Griffin Mary Rose Sweeney, People with intellectual disability and their families perspectives of Special Olympics Ireland: Qualitative findings from the SOPHIE study, Journal of Intellectual Disabilities, 2015
, Clinical effectiveness and cost-effectiveness of parenting interventions for children with severe attachment problems: a systematic review and meta-analysis., Health technology assessment (Winchester, England), 2015
S Downe, K Finlayson, C Melvin, H Spiby, S Ali, P Diggle, G Gyte, S Hinder, V Miller, P Slade, D Trepel, A Weeks, P Whorwell, M Williamson, Self-hypnosis for intrapartum pain management in pregnant nulliparous women: a randomised controlled trial of clinical effectiveness, BJOG: An International Journal of Obstetrics & Gynaecology, 2015
Rachel Richardson, Dominic Trépel, Amanda Perry, Shehzad Ali, Steven Duffy, Rhian Gabe, Simon Gilbody, Julie Glanville, Catherine Hewitt, Laura Manea, Stephen Palmer, Barry Wright, Dean McMillan, Screening for psychological and mental health difficulties in young people who offend: a systematic review and decision model, Health Technol Assess, 2015
Dominic Trépel, An Economic Analysis of Home Care Services for People with Dementia [Executive Summary], 2015
Wright, Barry and Barry, Melissa and Hughes, Ellen and Trepel, Dominic, Supplementary systematic review 2: studies of severe attachment problems with a follow-up of 10 years or longer, Clinical effectiveness and cost-effectiveness of parenting interventions for children with severe attachment problems: a systematic review and meta-analysis, 2015
Overend, Karen and Lewis, Helen and Bailey, Della and Bosanquet, Kate and Chew-graham, Carolyn and Ekers, David and Mitchell, Natasha and Nutbrown, Sarah and Parrott, Steve and Richards, David and others, STUDY PROTOCOL Open Access CASPER plus (CollAborative care in Screen-Positive versus usual GP care alone. The primary clinical outcome, depression severity, will be measured with the TRIALS, 2014
Barry Wright, David Marshall, Danielle Collingridge Moore, Hannah Ainsworth, Lisa Hackney, Joy Adamson, Shehzad Ali, Victoria Allgar, Liz Cook, Lisa Dyson, Elizabeth Littlewood, Rebecca Hargate, Anne McLaren, Dean McMillan, Dominic Trépel, Jo Whitehead, Chris Williams, Autism Spectrum Social Stories In Schools Trial (ASSSIST): study protocol for a feasibility randomised controlled trial analysing clinical and cost-effectiveness of Social Stories in mainstream schools., BMJ Open, 2014
Karen Overend, Helen Lewis, Della Bailey, Kate Bosanquet, Carolyn Chew-Graham, David Ekers, Samantha Gascoyne, Deborah Hems, John Holmes, Ada Keding, Dean McMillan, Shaista Meer, Natasha Mitchell, Sarah Nutbrown, Steve Parrott, David Richards, Gemma Traviss, Dominic Trépel, Rebecca Woodhouse & Simon Gilbody, CASPER plus (CollAborative care in Screen-Positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial, Trials, 2014
Fenn, B and Trepel, D and Dolan, C and Shoham, J and Sibson, V, Seasonal unconditional cash transfers and wasting in Niger, Annals of Nutrition and Metabolism, 63, 2013, p1002
Dominic Trépel, Shehzad Ali, Health-related Quality of Life Measures in Economic Evaluations of Child and Adolescence Mental Health Interventions: A Systematic Review, JOURNAL OF MENTAL HEALTH POLICY AND ECONOMICS, 2012
Trepel, Dominic, Financing Dementia-What money is available, what does dementia need and will the required resources be received?, 2012
Trepel, D., An update on the economics of dementia care in Ireland, Irish Medical Journal, 105, (2), 2012
Dominic Trépel, An economic perspective of dementia care in Ireland: maximising benefits and maintaining cost efficiency, 2011
Dominic Trépel, Economic analyses of dementia care in Ireland and Europe- perception of services and care, the market value of informal care and changes in service utilisation attributed to comorbid depression, 2011
Dominic Trépel, Informal cost of dementia care - a proxy-good valuation in Ireland, Economic and Social Review, 2011
Trepel, Dominic, Dementia-Specific Informal Care-Replacement Costs in Ireland, Irish Journal of Medical Science, 180, (Suppl 10), 2011, pS341
Trepel, Dominic, An economic perspective of dementia care in Ireland, 2011
Trepel, D, An Economic Perspective of Dementia Care in Ireland: Executive Summary, 2010
Non-Peer-Reviewed Publications
Hoang, Men and Zenker, Alina and Saha, Sanjib and Trepel, Dominic, Economic Evaluations of Strategies Targeting Pre-diagnosis Dementia: A Systematic Review, PROSPERO, CRD42024521521, 2024
Yigezu, Amanuel and Trépel, Dominic and Kibret, Solomon, Health Technology assessment-based Principles to Redesign the Health Insurance Benefits Package in Ethiopia: a Systematic Review, PROSPERO, CRD42024522605, 2024
Mikael Äijälä, Iracema Leroi, Dominic Trépel, Cost-effectiveness of hearing and vision support for residents with dementia in long-term care in Ireland: A Health Economic Analysis Plan (HEAP) for a simulation model for the SENSE-Cog Care feasibility trial, HRB Open Research, 2024
Yigezu, Amanuel and Galvin, Rose and Trépel, Dominic, Economic Evaluation of Comprehensive Geriatric Assessment: a Systematic Review, PROSPERO, CRD42023492586, 2023
Connelly JP, Boland Erin, Buckley Brenda, Curley Niall, Refaie Amr El, Galvin Miriam, Gibb Matthew, Graham Liz, Lennon Brendan, Valdes Alejandro Lopez, Mullally Anne-Michelle, Muller Nicole, Nolan-Palmer Janice, O'Nolan Gerald, O'Reilly Ciara, Rezk Valeria Raaft, Rochford-Brennan Helen, Tobin Katy, Tormey Helen, Trepel Dominic, Leroi Iracema, SENSE-Cog Residential Care: Hearing and vision support for residents with dementia in long-term care in Ireland: Protocol for a pilot cluster randomised controlled trial, 2023, -
Conneely, M and Leahy, S and Trepel, D, 267 What is the Impact of Acute Healthcare Utilisation on Functional Decline in Older Adults Over Time? A Population-Based Cohort Study, British Geriatrics Society Spring conference 2022, Online, 6-8 Apr 2022, 51, (Supplement_3), NIHR Journals Library, 2022, ppafac218--235
Saha, Sanjib and Thant, Poe Eindra and Jarl, Johan and Gerdtham, Ulf and Trepel, Dominic, A systematic review of inappropriate medication use and related consequences among patients with dementia, PROSPERO, CRD42022312570, 2022
Conneely, Mairead and Galvin, Rose and Robinson, Katie and Leahy, Siobhan and Trepel, Dominic and Devane, Declan and Jordan, Fionnuala, The impact of emergency department interventions to improve outcomes among older adults following Emergency Department discharge: Protocol for an Overview of Systematic Reviews, PROSPERO, CRD42020145315, 2020
Trepel, Dominic and Ahern, Elayne and Philips, Nicola and Mockler, David and McGettrick, Grainne and Fitzpatrick-Naidoo, Kyle, The effectiveness of community neurorehabilitation for persons with an acquired brain injury, PROSPERO, CRD42020148604, 2020
Mitchell, Eileen and Saha, Sanjib and Ahern, Elayne and Philips, Nicola and Mockler, David and McGettrick, Grainne and Trépel, Dominic, Economic evaluations of acquired brain injury (ABI) rehabilitation interventions: a systematic review, PROSPERO, CRD42020187469, 2020
Kinchin, Irina and Agar, Meera and Trepel, Dominic, Delirium: a review of cost of illness and economic evaluation studies, PROSPERO, CRD42020188487, 2020
Howlin, Claire and Tobin, Katy and O'Brien, Séan and Mockler, David and Trepel, Dominic, A systematic overview of systematic reviews examining the overall effectiveness of music interventions across all healthcare contexts in terms of physical, emotional, and cognitive outcomes, PROSPERO, CRD42020161762, 2019
Trends in healthcare cover and healthcare use for older adults in Ireland during the in, editor(s)Niall Turner, Orna Donoghue, Rose Anne Kenny , Publication Preview Source Wellbeing and Health in Ireland's over 50s 2009-2016, Trinity College Dublin, 2018, pp151 - 174, [Roe, Lorna and Thomas, Steve and Trépel, Dominic]
Plummer, Faye and McMillan, Dean and Trepel, Dominic and Manea, Laura, Diagnostic test accuracy of the GAD-7 and GAD-2 questionnaires when used as a screen for anxiety disorders, PROSPERO, CRD42014006494, 2014
Research Expertise
Projects
- Title
- A Cognitive Occupation-Based programme for people with Multiple Sclerosis: definitive trial (COB-MS)
- Summary
- Cognitive difficulties can have significant impacts on daily function and quality of life of people with multiple sclerosis (MS). Although a common symptom of MS, it is often not treated in clinical care, despite the potential for devastating impacts. When treated, occupational therapists are the healthcare professionals most commonly responsible for the assessment and management of cognitive symptoms in MS. Despite this, no cognitive rehabilitation intervention has been developed that is measured by and taught through an occupational participation perspective. The Cognitive Occupation-Based programme for people with MS (COB-MS) was developed to address the clinical treatment deficit. The COB-MS is a personalised, patient-centred, holistic, occupational therapy, cognitive rehabilitation intervention. It is aimed at improving daily life functioning for people with MS who are experiencing cognitive difficulties. The COB-MS has undergone extensive feasibility testing and has been found to be both feasible and acceptable by clinicians and participants with MS. The aim of this research is to estimate the clinical and cost-effectiveness of the COB-MS intervention relative to a treatment-asusual control group. This study is a single-blind, three-arm, pragmatic randomised trial with two SWATs. We will establish the effectiveness of both online and in-person delivery of the COB-MS, relative to control condition. This will be achieved through five separate work packages (WP), and follow FAIR data management principles: " WP1: Internal Pilot Phase. " WP2: Evaluation of the clinical effectiveness of the COB-MS through quantitative and qualitative outcomes. " WP3: COB-MS cost-effectiveness analysis. " WP4: Process Evaluation. " WP4: Two SWATs focused on core outcome set development and retention to be carried out in conjunction with the main trial. This definitive trial, and associated SWATs, are led by the needs of the MS community at national and international levels and have a strong PPI-focus throughout. This research is innovative and very timely and links with priority research areas in multiple sclerosis rehabilitation, occupational therapy, and trial methodology, ensuring the international relevance of the research to the MS rehabilitation research community, knowledge-users, and those living with MS. The COB-MS team consists of experts in multiple disciplines, trial methodology, health economics, statistics, health service research, and related disciplines.
- Funding Agency
- Health Research Board (HRB) (Dublin, IE)
- Date From
- 01 May 2025
- Date To
- 30 April 2029
- Title
- Personalised Exercise Rehabilitation in Cancer Survivorship (PERCS) 2.0 " Developing an Evidence-Informed National Implementation Strategy
- Funding Agency
- Health Research Board (HRB)
- Date From
- tbc
- Date To
- tbc
- Title
- Multi-National Implementation of Multimodal Strategies to promote Healthy Brain Ageing in Sub-Saharan Africa (The AFRICA-FINGERS Project)
- Summary
- Given unprecedented expansions in aged populations globally, cognitive impairment and dementia present significant challenges for healthy longevity. More than half of all dementia patients (>60%) are living in low- and middle-income countries (LMICs). LMICs, like Sub-Saharan Africa (SSA) are fast-aging societies facing the dementia epidemic already, with cases projected to rise to 357% in the next two decades. The burden will be insurmountable in the coming years if preventive measures are not found and applied. Encouraging reports from the Lancet Commission on Dementia Prevention, Intervention, and Care estimates up to 40% of dementia as preventable. Risk reduction strategies simultaneously targeting multiple risk factors have been proposed by the World Health Organization (WHO) as optimal prevention approaches. One such successful strategy is the landmark Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multimodal lifestyle modification trial that demonstrated improvements in cognitive and health outcomes 2-years post-intervention. Researchers globally are adapting and implementing this approach, within a World-Wide network (led by study co-CI, with the international efforts for bio-specimen repository led by this study's CI), but not yet in Africa. Therefore, we propose a multi-national collaboration towards brain health promotion in SSA: The AFRICA FINGERS Program. AFRICA-FINGERS represents the first attempt to coordinate and implement culturally informed multidomain dementia-risk reduction interventions across SSA, with sustainability goals embedded within the initiative. The overarching aim of our proposal is to reduce cognitive impairment and promote healthy aging in African populations by optimizing the management of core modifiable risk factors identified by the Lancet Commission on prevention, the WHO policy for addressing NCDs and, by members of our teams working within these indigenous populations as well as, crucially, the indigenous community members themselves. Here we propose two primary objectives: A) To co-design with local stakeholders a bespoke personalized multidomain lifestyle dementia risk-modification protocol, and collect data on intervention effectiveness, bio-mechanisms and cost-effectiveness. We are proposing to identify and test solutions that are contextually and culturally appropriate, economically viable, and sustainable. B) To promote sustained efficacy of the intervention and scalability via community-wide implementation and harmonize methods for adoption in partner countries and across similar demographics. AFRICA-FINGERS is a multinational brain health promotion initiative (at-risk adults >50years, n=600) set within established academic research infrastructures with already-phenotyped cohorts in Kenya and Nigeria. The program will be nested within the WW-FINGERS framework, with the central hub at the Brain and Mind Institute (BMI), Aga Khan University in Nairobi, Kenya. The BMI addresses acute and rising gaps in research capacity and interventions for mental and neurological conditions in Kenya. Given the BMI Vision and Values, diverse and relevant expertise of its members, its location and connections, including a registered Clinical Trials Unit, Lab facility and Imaging core; the BMI is ideally suited as the central hub for AFRICA FINGERS and its primary site. The secondary sites are Department of Public Health, Kilifi county, Kenya; University of Lagos, Nigeria and The Research Centre for Ageing Cognition and Psychological Health, Nnamdi Azikiwe University (NAU) Awka, Nigeria; all conducting dementia clinical studies. Guided by the MRC/NIHR framework for complex interventions, this collaborative project will partner with WW-FINGERS, Davos Alzheimer's Collaborative, Global-Brain-Health-Institute, Global-Dementia-Prevention-Program, Neurovision, Oasis Diagnostics, Alzheimer's Disease Data Initiative and Alzheimer's Disease International.
- Funding Agency
- Medical Research Council: GB
- Date From
- 30 April 2024
- Date To
- 29 April 2029
- Title
- A randomised controlled pilot trial of psilocybin with psychological support for cocaine use disorder
- Summary
- Background: Cocaine use disorder has a detrimental impact on the individual, their families, and society. Psilocybin with psychological support, a synergistic combination of pharmacology and psychological support, is emerging as a multi-modal treatment paradigm that is showing therapeutic benefits for substance use disorders. Psilocybin activates cortical 5-HT2A receptors, induces transient alterations of brain connectivity in humans, and promotes synaptogenesis and neural plasticity in rodents. It is not yet known whether psilocybin with psychological support will play a therapeutic anti-addictive role in cocaine use disorder. Aim: Assess trial procedures to inform a future definitive trial of psilocybin with psychological support for cocaine use disorder. Methods: A 15-week randomised double-blind placebo-controlled pilot feasibility study of a single dose of oral psilocybin (25mg) or diphenhydramine 100mg (1:1) and 6 sessions of psychological support (3 preparation, 3 integration) will be conducted in 24 participants meeting DSM-5 criteria for cocaine use disorder (at least moderate severity) and who are seeking treatment. Participants will require a score of "4 on the Severity of Dependence Scale and self-reported cocaine use in the past month. Underpinned by the Medical Research Council Framework, the primary outcomes of this feasibility study will assess trial procedures to inform a definitive trial, determined by recruitment rates, adherence, retention, incidents/adverse events, and acceptability. Progression criteria, including a traffic light system of `stop", `change` and `go" thresholds will be used to facilitate decision-making for the definitive trial. The exploratory secondary outcomes will be cocaine use measured by the Timeline Follow-Back method (percentage days abstinent, complete/sustained abstinence, number of days to first use of cocaine after the drug administration session) verified by urine toxicology, selfreported cocaine craving assessed by the Cocaine Craving Questionnaire-Brief, and cocaine withdrawal using the Cocaine Selective Severity Assessment. Further exploratory measures will assess mood, anxiety, psychedelic experience, social connectedness and functionality using reliable and validated clinical measures. Conclusion: We envisage that this study will provide the necessary information to launch a definitive trial to determine whether psilocybin with psychological support can reduce cocaine use and craving and improve outcomes in treatment seeking adults with moderate to severe DSM-5 cocaine use disorder.
- Funding Agency
- Health Research Board
- Date From
- 01 December 2023
- Date To
- 30 November 2026
- Title
- Dementia Research Network Ireland (DRNI)
- Summary
- DRNI links leading researchers across several disciplines in the areas of dementia and ND, it is novel in its multi-disciplinary focus and strategic in its objective to enhance research co-operation and co-ordination across the island of Ireland. By facilitating collaborative consensus and policy based projects and supporting knowledge exchange and public patient events DRNI seeks to improve our understanding of the causes and mechanisms of dementia and neurodegeneration, the effectiveness of different models of care and the policy changes required to improve the quality of life for persons with dementia and neurodegenerative conditions and their caregivers. The inter-disciplinary nature of the network is highly innovative and reflects the emerging international evidence of the role of multi-modal influences on dementia and neurodegeneration. It reflects the network members" belief that the integration of knowledge and practice from diverse research traditions has the potential to radically improve our understanding of dementia and ND, in relation to prevention, care and quality of life. To further network objectives DRNI works collaboratively with the Structured Population and Health Services Research Education (SPHeRE) network which strives to increase cross-disciplinary interaction and collaboration in the area of population health and health services research. Combined the networks serve to act as a conduit to link researchers in the field of dementia and ND with statutory and non-statutory bodies, including, funding agencies, government, patient advocacy, charities, health service organisations, industries, and philanthropic organisations.
- Funding Agency
- Health Research Board
- Date From
- 2022
- Date To
- 2024
- Title
- Development and evaluation of the utility of video tutorials in dissemination and implementation of trial reporting guidelines
- Summary
- The HRB-funded project 'Development and evaluation of the utility of video tutorials in dissemination and implementation of trial reporting guidelines' builds on an MRC funded project to develop extensions of the CONSORT and SPIRIT checklist for randomized controlled trials using surrogate endpoints as primary outcomes (led by Taylor and Ciani & managed by Manyara). Having completed the scoping review, e-Delphi study, and consensus meeting in March 2023, we anticipate the completion and availability of the two surrogate outcome extensions in June 2023. In spite of the development of a number of methodological guidelines, there remains a question as to how best to improve the use and uptake of methodological guidance in health research. Some interventions (including training, translation, encouraging and checking adherence) to improve the uptake and adherence to reporting methodological guidelines have been developed (Blanco et al 2019). However, there remains a limited evidence base around both theoretical basis of these interventions and their effectiveness. One approach is training on the use of reporting guidelines, increasing understanding, encouraging adherence among other interventions (Blanco et al 2019). However, most of the current interventions aimed at training and improving understanding have not been evaluated (Blanco et al 2019) nor have they considered other creative strategies such using audio-visuals. There is evidence to suggest that using audio-visuals, such as video abstracts, improves research dissemination, understanding of findings, and impact (Zong et al 2019, Bredbenner and Simon 2019). Leveraging on the MRC funded project and availability of our new extension we seek to: develop and evaluate the impact of video tutorials as strategies of disseminating and supporting implementation of the guidelines; evaluate the utility of the video tutorials in increasing knowledge and skills in use of the guidelines; explore utility of video tutorials in wider knowledge translation efforts of health reporting guidelines; provide a timely opportunity for future collaboration between Dublin, Glasgow and Bocconi university groups in trial methodology research. The project objectives are: 1. To co-develop with stakeholders (including trialists, journal editors, methodologists, patients) video tutorials to assist the understanding of the importance of surrogate outcomes in trials and how to apply the CONSORT and SPIRIT extensions for trials with surrogate primary outcome. (Work Package 1). 2. To evaluate knowledge, attitudes, and skills of stakeholders (trialists, journal editors, methodologists, patients) before and after viewing the video tutorials using (Work Package 2) 3. To explore perceptions and experiences of users of video tutorials to inform wider knowledge translation in terms of the uptake and use of health reporting guidelines (Work Package 2)
- Funding Agency
- Health Research Board: IE
- Date From
- 1 May 2023
- Date To
- 30 November 2024
- Title
- SENSE-Cog Care: A feasibility study of hearing and vision support to improve quality of life in care home residents with dementia
- Summary
- Of the 55,000 people with dementia in Ireland, nearly 17,000 live in nursing homes (Irish care homes). Over 90% of these residents have significant hearing and vision problems that are frequently undetected or under-corrected. Poor sensory function can worsen quality of life for residents with dementia (RwD) by making communication more difficult and increasing confusion and challenging behaviour. The study aims to ascertain the feasibility of delivery, acceptability and tolerability of a sensory support intervention in Irish nursing homes. To explore whether the sensory support intervention may be effective in improving quality of life and other outcomes for RwD and nursing home staff. To explore what Care as Usual looks like in nursing homes, and lastly, to evaluate cost-effectiveness parameters of the intervention. The findings from this study will inform progression to a definitive trial and contribute to emerging evidence of care home research methodology.
- Funding Agency
- Health Research Board
- Date From
- 2022
- Date To
- 2024
- Title
- Developing a Regional Capacity in Health Economics for BrainLat: A cross-sectional study to inform economic evaluations on dementia in Chile
- Summary
- In Chile, there are currently over 200,000 persons living with dementia (PLWD) and, by 2050, this number is forecasted to exceed half a million. The associated national cost of dementia is $183 Million per annum and, by 2050, this will reach $457 Million. Given the implications of dementia, the Chilean Ministry of Health launched `Plan Nacional de Demencia: 2017-2025" (cost: $12.5 Million) and, to support implementation, this project will enhance dementia-specific Health Economics capacity for Chile (and for the wider BrainLat region). This BrainLat Seed Research Grant aims to estimate stage-specific Quality-Adjusted LifeYears (QALYs), and relevant costs, to allow adaptation of international economic models to inform resource allocation decisions in Chile. By providing proof-of-concept, this initiative also lays foundations to scale up dementia-specific health economic capacity to benefit the wider RedLat region. Further information: https://brainlat.uai.cl/research-and-networking-projects/seed-grants/developing-a-regional-capacity-in-health-economics-for-brainlat-a-cross-sectional-study-to-inform-economic-evaluations-on-dementia-in-chile/
- Funding Agency
- BrainLat
- Date From
- 2021
- Date To
- 2023
- Title
- ValueCare: The VALUE of unpaid CARE in Ireland, and how economic consequence varies by social, economic and health condition
- Summary
- Family carers are lauded as the backbone of care provision in Ireland and are an essential complement to formal healthcare. Yet their contribution is not explicitly valued and can commonly be overlooked by decision-makers. Drawing on responses of over 1,400 Irish carers surveyed this year, this Civil Society Partner proposes will estimate of the economic value of unpaid caring activity and, for the first time, will disaggregate the monetary value of carer contribution by social and economic situation of the carer and the condition of the cared-for person. The outputs will be influential many ongoing high-level policy and legislative discussions.
- Funding Agency
- Irish Research Council
- Date From
- 2022
- Date To
- 2023
- Title
- The Economics of Brain Health: A state-of-the-art decision analytic framework to compare a range of potential alternative investments to prevent, treat or care for dementia
- Summary
- By 2030, there will be 65.7 million people with dementia worldwide and associated costs will reach €2 trillion per year. With no clinically meaningful treatment yet available, policymakers remain uncertain on how best to allocate resources to tackle dementia. Future health program allocation decisions will ideally account for evolving needs and opportunities. Potential intervention will span prevention, treatment, and care. The toolkit is expected to expand over time as research discovers new intervention options. Optimal investment portfolios will reflect local epidemiology and resources, as well as up-to-date estimates of intervention costs and effectiveness. The goal of this 3-year project (2022 " 2025) is to provide practical analytic tools to support health intervention policy, programming, and funding decisions related to Brain Health and Dementia.
- Funding Agency
- Global Brain Health Institute
- Date From
- 2022
- Date To
- 2025
- Title
- Alignment, Harmonisation, and Results: translating Core Outcome Measures to Improve Care (COM-IC) for People Living with Dementia
- Summary
- The Core Outcome Measures for Improving Care (COM-IC) project aims to identify a suite of outcome measures that are aligned with stakeholder goals; and develop guidelines for implementation that ensure Australia"s efforts to improve the lives of people living with dementia are unequivocally realised. The COM-IC Project will use a participatory co-design strategy to incorporate practical knowledge, experience and preferences of all stakeholders as inputs in each step of the process. The participatory co-design framework will ensure the suite of core outcomes identified and recommended to evaluate dementia interventions and care delivery model are important, relevant, authentic and practical for each stakeholder group. Research objectives Primary Objective: Development of a comprehensive and appropriate suite of core outcome measures accompanied by guidelines (developed according to NHMRC guideline methodology) to monitor and evaluate impacts of care delivery models at individual, organisation and system levels, that are informed by all stakeholders. Secondary Objectives 1. To understand, report and collectively prioritise multiple stakeholders" preferences on core outcome measures to evaluate success of interventions and care delivery models for people living with dementia 2. To map the core outcome sets for dementia into the indicators that are routinely collected in the Australian health and aged care systems To achieve consensus of what to recommend as a suite of core outcome measures for dementia. 3. To determine best practices in measuring, collecting, curating, evaluating, reporting and translating the recommended suite of core outcome measures for dementia. 4. To develop methods to monitor the delivery of Commonwealth and State, Health and Aged Care services at the level of Local Hospital Networks.
- Funding Agency
- National Health and Medical Research Council (NHMRC)
- Date From
- 2022
- Date To
- 2024
- Title
- Towards an integrated model of care for older adults transitioning from the Emergency Department to the community
- Summary
- Ireland like many other countries has seen a steady increase in life expectancy and has an ageing population. Internationally, health and social care systems are recognising that sustainable healthcare strategies for older adults need to move from acute, episodic care to longitudinal, coordinated and integrated care models. International evidence demonstrates that older adults account for up to 25% of all emergency department (ED) attendances and experience high rates of adverse outcomes following emergency care such as unscheduled ED return, unplanned hospital admission and functional decline. Given the significant incidence of adverse events in this population, there is very little research conducted to explore how integrated care may improve outcomes among those who are discharged from the ED. The overall aim of this programme of research is to develop and examine an evidence-based model of integrated care for older people following ED index visit that is planned around their needs and choices, to support them to live well in their own homes and communities. This aim will be realised through collaboration and meaningful engagement by the research team with service users, advocacy groups, health-decision makers and health-practitioners. The objectives include qualitative and quantitative syntheses of international evidence, analysis of local and national routine health data and meaningful engagement with stakeholders to inform the design, delivery and evaluation of an integrated model of care to improve patient, process, clinical and economic outcomes post ED index visit. This programme of work responds to and resonates with key priorities identified in national ageing, emergency and integrated care strategies relating to the development and delivery of a continuum of high quality care services and supports that are responsive to the changing needs and preferences of older adults. The proposal also aligns with key objectives of the WHO Guidelines on Integrated Care for Older People (2017).
- Funding Agency
- Health Research Board
- Date From
- 2021
- Date To
- 2026
- Title
- Health Economic Partnership between Trinity College Dublin and Public Health Agency Northern Ireland
- Summary
- In collaboration between the Public Health Agency Northern Ireland (PHA-NI) and Trinity College Dublin (TCD), a partnership has been established that aims to appraise the current basis for public health policy for older people who become frail. To achieve this aim, the central objectives of Phase 1 are to: (1) Critically appraise current evidence that support PHA-NI frailty policy; (2) Identify evidence gaps in knowledge on appropriate intervention strategies and agree appropriate searches to obtain best available evidence on effective strategies, and; (3) Develop a framework to determine the most efficient design of services across NI. In Phase 2, the best available evidence gathered during Phase 1, is incorporated into a decision analytic model that simulates the relative cost effectiveness of public health interventions for frail older people and ultimately aims to inform future public health policy for Northern Ireland.
- Funding Agency
- Health and Social Care Northern Ireland (R&D Division)
- Date From
- 2020
- Date To
- 2023
- Title
- "Right Care": a programme of research to enhance safe and appropriate care for older patients in Ireland
- Funding Agency
- Health Research Board
- Date From
- 2018
- Date To
- 2023
- Title
- An Economic evaluation of Acquired Brain Injury Rehabilitation Models: Developing evidence to inform the Irish Health System
- Funding Agency
- Irish Research Council
- Date From
- 2020
- Date To
- 2022
- Title
- The Frail Brain and the Frail Body: Impact of FRAILty and COGnitive impairment on trajectories, patterns and costs in care in old age
- Funding Agency
- Health Research Board
- Date From
- 2019
- Date To
- 2024
Recognition
Representations
I am serving as on scientific panner for 'The Research Foundation " Flanders' - locaaly know as Dutch: Fonds voor Wetenschappelijk Onderzoek (FWO)" Vlaanderen.
Editorial board of Alzheimers and Dementia Journal Since my last application to TCD senior promotions committee, I have been promoted within the journal to Senior Associate Editor.
Scientific review committee, EU Joint Program for Neurogenerative Research (JPND)