Publications and Further Research Outputs
Peer-Reviewed Publications
Garrett, A., Allen, S., Durkie, M., Burghel, G.J., Robinson, R., Callaway, A., Field, J., Frugtniet, B., Palmer-Smith, S., Grant, J., Pagan, J., McDevitt, T., Rowlands, C.F., McVeigh, T., Hanson, H., Turnbull, C., Turnbull, C., Garrett, A., Loong, L., Choi, S., Torr, B., Allen, S., Durkie, M., Callaway, A., Drummond, J., Burghel, G.J., Robinson, R., Berry, I.R., Wallace, A.J., Eccles, D.M., Tischkowitz, M., Ellard, S., Hanson, H., Baple, E., Evans, D.G., Woodward, E., Lalloo, F., Samant, S., Lucassen, A., Znaczko, A., Shaw, A., Ansari, A., Kumar, A., Donaldson, A., Murray, A., Ross, A., Taylor-Beadling, A., Taylor, A., Innes, A., Brady, A., Kulkarni, A., Hogg, A.C., Bowden, A.R., Hadonou, A., Coad, B., McIldowie, B., Speight, B., DeSouza, B., Mullaney, B., McKenna, C., Brewer, C., Olimpio, C., Clabby, C., Crosby, C., Jenkins, C., Armstrong, C., Bowles, C., Brooks, C., Byrne, C., Maurer, C., Baralle, D., Chubb, D., Stobo, D., Moore, D., O'Sullivan, D., Donnelly, D., Randhawa, D., Halliday, D., Atkinson, E., Rauter, E., Johnston, E., Maher, E., Sofianopoulou, E., Petrides, E., McRonald, F., Pelz, F., Frayling, I., Corbett, G., Rea, G., Clouston, H., Powell, H., Williamson, H., Carley, H., Thomas, H.J.W., Tomlinson, I., Cook, J., Hoyle, J., Tellez, J., Whitworth, J., Williams, J., Murray, J., Campbell, J., Tolmie, J., Field, J., Mason, J., Burn, J., Bruty, J., Callaway, J., Grant, J., Del Rey Jimenez, J., Pagan, J., VanCampen, J., Barwell, J., Monahan, K., Tatton-Brown, K., Ong, K.R., Murphy, K., Andrews, K., Mokretar, K., Cadoo, K., Smith, K., Baker, K., Brown, K., Reay, K., McKay Bounford, K., Bradshaw, K., Russell, K., Stone, K., Snape, K., Crookes, L., Reed, L., Taggart, L., Yarram, L., Cobbold, L., Walker, L., Walker, L., Hawkes, L., Busby, L., Izatt, L., Kiely, L., Hughes, L., Side, L., Sarkies, L., Greenhalgh, K.-L., Shanmugasundaram, M., Duff, M., Bartlett, M., Watson, M., Owens, M., Bradford, M., Huxley, M., Slean, M., Ryten, M., Smith, M., Ahmed, M., Roberts, N., O'Brien, C., Middleton, O., Tarpey, P., Logan, P., Dean, P., May, P., Brace, P., Tredwell, R., Harrison, R., Hart, R., Kirk, R., Martin, R., Nyanhete, R., Wright, R., Martin, R., Davidson, R., Cleaver, R., Talukdar, S., Butler, S., Sampson, J., Ribeiro, S., Dell, S., Mackenzie, S., Hegarty, S., Albaba, S., McKee, S., Palmer-Smith, S., Heggarty, S., MacParland, S., Greville-Heygate, S., Daniels, S., Prapa, S., Abbs, S., Tennant, S., Hardy, S., MacMahon, S., McVeigh, T., Foo, T., Bedenham, T., Cranston, T., McDevitt, T., Clowes, V., Tripathi, V., McConnell, V., Woodwaer, N., Wallis, Y., Kemp, Z., Mullan, G., Pierson, L., Rainey, L., Joyce, C., Timbs, A., Reuther, A.-M., Frugtniet, B., DeSouza, B., Husher, C., Lawn, C., Corbett, C., Nocera-Jijon, D., Reay, D., Cross, E., Ryan, F., Lindsay, H., Oliver, J., Dring, J., Spiers, J., Harper, J., Ciucias, K., Connolly, L., Tsang, M., Brown, R., Shepherd, S., Begum, S., Daniels, S., Tadiso, T., Linton-Willoughby, T., Heppell, H., Sahan, K., Worrillow, L., Allen, Z., Watt, C., Hegarty, M., Mitchell, R., Coles, R., Nickless, G., Cojocaru, E., Doal, I., Sava, F., McCarthy, C., Jeeneea, R., Goudie, D., McConachie, M., Botosneanu, S., Kavanaugh, G., Russell, K., Sherlaw, C., Tsoulaki, O., Forde, C., Petley, E., Jones, A.-B., Oprych, K., Pry, Classification of variants of reduced penetrance in high-penetrance cancer susceptibility genes: Framework for genetics clinicians and clinical scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK), Genetics in Medicine, 27, (2), 2025
O'Brien H, Murray J, Orfali N, Fahy RJ., Pulmonary complications of bone marrow transplantation., Breathe (Sheffield, England), 20, (3), 2024, p240043
Heeney A, Wu R, Fitzgerald C, Orfali N, Akasheh N, Magee C., VEXAS syndrome as a cause for multifocal, relapsing head and neck inflammation., Clinical case reports, 12, (7), 2024, pe9126
Guinan E., Heuston C., Sheill G., Ní Chonghaile M., Orfali N, Health professionals" perceptions of prehabilitation before haematopoietic cell transplantation to optimise candidacy in older adults, Supportive Care in cancer, 32, (465), 2024
Jimenez-Chillon, C., Othman, J., Taussig, D., Jimenez-Vicente, C., Martinez-Roca, A., Tiong, I.S., Jain, M., Aries, J., Cakmak, S., Knapper, S., Kristensen, D.T., Murthy, V., Galani, J.Z., Kallmeyer, C., Ngu, L., Veale, D., Bolam, S., Orfali, N., Parker, A., Manson, C., Parker, J., Erblich, T., Richardson, D., Mokretar, K., Potter, N., Overgaard, U.M., Roug, A.S., Wei, A.H., Esteve, J., Jädersten, M., Russell, N., Dillon, R., Venetoclax-based low intensity therapy in molecular failure of NPM1-mutated AML, Blood Advances, 8, (2), 2024, p343-352
Helen O'Brien, John Murray, Nina Orfali, Ruairi J. Fahy, Pulmonary complications of bone marrow transplantation, Breathe, 20, (3), 2024, p240043
Aoife Heeney, Rachael Wu, Fitzgerald C, Orfali N, Akasheh N, Magee C, VEXAS syndrome as a cause for multifocal, relapsing head and neck inflammation., Clinical case reports, 12, (7), 2024
Millar, S.R., Mohamed, M.B., Mykytiv, V., McMorrow, R., Donnelly, C., O"Leary, E., Orfali, N., Murphy, P., Browne, P.V., Quinn, J., O"Gorman, P., Ryan, M.F., Clifford, R., Hassadi, E.E., O"Shea, D., Gilligan, O., Krawczyk, J., O"Dwyer, M.E., Szegezdi, E., Cahill, M.R., Blood Cancer Network Ireland (BCNI) and National Cancer Registry Ireland (NCRI) collaboration: challenges and utility of an Enhanced Blood Cancer Outcomes Registry (EBCOR) pilot, Irish Journal of Medical Science, 193, (6), 2024, p2615-2623
Rowlands, C.F., Garrett, A., Allen, S., Durkie, M., Burghel, G.J., Robinson, R., Callaway, A., Field, J., Frugtniet, B., Palmer-Smith, S., Grant, J., Pagan, J., Mcdevitt, T., Mcveigh, T.P., Hanson, H., Whiffin, N., Jones, M., Turnbull, C., Turnbull, C., Garrett, A., Loong, L., Choi, S., Torr, B., Allen, S., Durkie, M., Callaway, A., Drummond, J., Burghel, G.J., Robinson, R., Berry, I.R., Wallace, A.J., Eccles, D.M., Tischkowitz, M., Ellard, S., Hanson, H., Baple, E., Evans, D.G., Woodward, E., Lalloo, F., Samant, S., Lucassen, A., Znaczko, A., Shaw, A., Ansari, A., Kumar, A., Donaldson, A., Murray, A., Ross, A., Taylor-Beadling, A., Taylor, A., Innes, A., Brady, A.F., Kulkarni, A., Hogg, A.C., Bowden, A.R., Hadonou, A., Coad, B., McIldowie, B., Speight, B., DeSouza, B., Mullaney, B., McKenna, C., Brewer, C., Olimpio, C., Clabby, C., Crosby, C., Jenkins, C., Armstrong, C., Bowles, C., Brooks, C., Byrne, C., Maurer, C., Baralle, D., Chubb, D., Stobo, D., Moore, D., O'Sullivan, D., Donnelly, D., Randhawa, D., Halliday, D., Atkinson, E., Rauter, E., Johnston, E., Maher, E., Sofianopoulou, E., Petrides, E., McRonald, F., Pelz, F., Frayling, I., Corbett, G., Rea, G., Clouston, H., Powell, H., Williamson, H., Carley, H., Thomas, H.J.W., Tomlinson, I., Cook, J., Hoyle, J., Tellez, J., Whitworth, J., Williams, J., Murray, J., Campbell, J., Tolmie, J., Field, J., Mason, J., Burn, J., Bruty, J., Callaway, J., Grant, J., Del Rey Jimenez, J., Pagan, J., VanCampen, J., Barwell, J., Monahan, K., Tatton-Brown, K., Ong, K.R., Murphy, K., Andrews, K., Mokretar, K., Cadoo, K., Smith, K., Baker, K., Brown, K., Reay, K., Bounford, K.M., Bradshaw, K., Russell, K., Stone, K., Snape, K., Crookes, L., Reed, L., Taggart, L., Yarram-Smith, L., Cobbold, L., Walker, L., Walker, L., Hawkes, L., Busby, L., Izatt, L., Kiely, L., Hughes, L., Side, L., Sarkies, L., Greenhalgh, K.-L., Shanmugasundaram, M., Duff, M., Bartlett, M., Watson, M., Owens, M., Bradford, M., Huxley, M., Slean, M., Ryten, M., Smith, M., Ahmed, M., Roberts, N., O'Brien, C., Middleton, O., Tarpey, P., Logan, P., Dean, P., May, P., Brace, P., Tredwell, R., Harrison, R., Hart, R., Kirk, R., Martin, R., Nyanhete, R., Wright, R., Martin, R., Davidson, R., Cleaver, R., Talukdar, S., Butler, S., Sampson, J., Ribeiro, S., Dell, S., Mackenzie, S., Hegarty, S., Albaba, S., McKee, S., Palmer-Smith, S., Heggarty, S., MacParland, S., Greville-Heygate, S., Daniels, S., Prapa, S., Abbs, S., Tennant, S., Hardy, S., MacMahon, S., McVeigh, T., Foo, T., Bedenham, T., Cranston, T., McDevitt, T., Clowes, V., Tripathi, V., McConnell, V., Woodwaer, N., Wallis, Y., Kemp, Z., Mullan, G., Pierson, L., Rainey, L., Joyce, C., Timbs, A., Reuther, A.-M., Frugtniet, B., DeSouza, B., Husher, C., Lawn, C., Corbett, C., Nocera-Jijon, D., Reay, D., Cross, E., Ryan, F., Lindsay, H., Oliver, J., Dring, J., Spiers, J., Harper, J., Ciucias, K., Connolly, L., Tsang, M., Brown, R., Shepherd, S., Begum, S., Daniels, S., Tadiso, T., Linton-Willoughby, T., Heppell, H., Sahan, K., Worrillow, L., Allen, Z., Watt, C., Hegarty, M., Mitchell, R., Coles, R., Nickless, G., Cojocaru, E., Doal, I., Sava, F., McCarthy, C., Jeeneea, R., Goudie, D., McConachie, M., Botosneanu, S., Kavanaugh, G., Russell, K., Sherlaw, C., Tsoulaki, O., Forde, C., Petley, E.,, The PS4-likelihood ratio calculator: flexible allocation of evidence weighting for case-control data in variant classification, Journal of Medical Genetics, 61, (10), 2024, p983-991
Chris Armstrong, Au WY, Ma ESK, Wong SHM, Orfali N, Sustained spontaneous remission in KMT2A-MLLT3 mutated myeloid sarcoma., Annals of hematology, 102, (5), 2023, p1271-1274
Armstrong C, Au WY, Ma ESK, Wong SHM, Orfali N., Sustained spontaneous remission in KMT2A-MLLT3 mutated myeloid sarcoma., Annals of hematology, 102, (5), 2023, p1271-1274
Gomez-Arteaga, A., Orfali, N., Pasciolla, M., Baptiste, A., Guindine, I., Hsu, J., Lin, J., Mayer, S.A., Phillips, A.A., Shore, T.B., Simonson, P.D., DiCarlo, E., Yoon, S., Muthukumar, T., van Besien, K., Haploidentical allogeneic stem cell transplantation with post-transplant cyclophosphamide and subsequent kidney transplant for patients with severe sickle cell disease with end-stage kidney disease (ESKD), Bone Marrow Transplantation, 58, (7), 2023, p835-838
Elhadad S, Amy Chadburn, Magro C, Koen van Besien, Elisha D.O. Roberson, John Atkinson, Terry H, Greenberg J, Reid W, Chapin J, Dennis C. Copertino Jr, Geramfard S, Rodriguez LB, Orfali N, Gerghis U, Tsiporah Shore, Mayer S, Ahamed J, Jeffrey Laurence, C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy., Bone marrow transplantation, 57, (9), 2022, p1445-1447
Armstrong, Chris, Conneally, Eibhlin, Flynn, Catherine M., Gardiner, Nicola, Foy-Stones, Hayley, Kelly, Aidan, Chonghaile, Mairead Ni, Orfali, Nina, The Easix Score Predicts Overall Survival and Late Relapse in Patients Undergoing Reduced Intensity Conditioned Allogeneic Stem Cell Transplantation for Myeloid Disease, Blood, 140, (Supplement 1), 2022, p12900-12901
Benjamin DN, O'Donovan TR, Laursen KB, Orfali N, Cahill MR, Nigel Mongan, Gudas LJ, McKenna SL, All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism., Frontiers in oncology, 2022
James Dillon, Vitaliy Mykytiv, Catriona Keenan, Brendan Mullaney, Nina Orfali, Kevin Ryan, Cleona Duggan, Maeve P. Crowley, Management of a patient with acute myeloid leukaemia with a diagnosis of type 2 von Willebrand disease and a novel variant within the von Willebrand factor (VWF) gene, British Journal of Haematology, 199, (2), 2022
Chandni Patel, Michelle Pasciolla, Abramova R, David Salerno, Gomez-Arteaga A, Shore TB, Orfali N, Mayer S, Hsu J, Phillips AA, Chaekal OK, Satlin MJ, Soave R, Kodiyanplakkal RPL, Drelick A, Plate M, Besien KV, Pre-Hematopoietic Stem Cell Transplantation Rituximab for Epstein-Barr Virus and Post-Lymphoproliferative Disorder Prophylaxis in Alemtuzumab Recipients., Transplantation and cellular therapy, 29, (2), 2022, p132.e1-132.e5
Mohamed, Bakri Mohamed, Millar, Sean R., Mykytiv, Vitaliy, McMorrow, Rose, Donnelly, Conan, Walsh, Paul M., O'Leary, Eamonn, Orfali, Nina, Murphy, Philip, Browne, Paul V., Quinn, John, O'Gorman, Peter, Clifford, Ruth, El Hassadi, Ezzat, Gilligan, Oonagh, Krawczyk, Janusz, O'Dwyer, Michael E., Szegezdi, Eva, Cahill, Mary R., Examining the Usefulness of the Charlson Comorbidity Index to Predict Early Mortality in Patients with Acute Myeloid Leukaemia, Blood, 138, (Supplement 1), 2021, p1218-1218
Chaekal OK, Soave R, Zhengming Chen, Shore T, Mayer S, Phillips A, Mei Hsu J, ALEXANDRA GOMEZ-ARTEAGA, Rennert H, Drelick A, Orfali N, Walsh TJ, Small CB, RosyPriya Kodiyanplakkal, Plate M, Satlin MJ, van Besien K, Adenovirus viremia after in vivo T-cell depleted allo-transplant in adults: low lymphocyte counts are associated with uncontrolled viremia and fatal outcomes., Leukemia & lymphoma, 63, (2), 2021, p435-442
Orfali N., Jhanwar Y., Koo C., Pasciolla M., Baldo M., Cuvilly E., Furman R., Gergis U., Greenberg J., Guarneri D., Hsu J.-M., Leonard J.P., Mark T., Mayer S., Maignan K., Martin P., Opong A., Pearse R., Phillips A., Rossi A., Ruan J., Rutherford S.C., Ryan J., Suhu G., Van Besien K., Shore T., Sequential intensive chemotherapy followed by autologous or allogeneic transplantation for refractory lymphoma, Leukemia and Lymphoma, 2021
Nina Orfali and Mei-Jie Zhang and Mariam Allbee-Johnson and Jaap Jan Boelens and Andrew S. Artz and Claudio G. Brunstein and Ian K. McNiece and Filippo Milano and Muhammed B. Abid and Lynette Chee and Miguel A. Diaz and Michael R. Grunwald and Peiman Hematti and Jingmei Hsu and Hillard M. Lazarus and Pashna N. Munshi and Timothy Prestidge and Olle Ringden and David Rizzieri and Marcie L. Riches and Sachiko Seo and Melhem Solh and Scott Solomon and David Szwajcer and Jean Yared and Koen van Besien and Mary Eapen, Planned granulocyte-colony stimulating factor adversely impacts survival after allogeneic hematopoietic cell transplantation performed with Thymoglobulin for myeloid malignancy, Transplantation and Cellular Therapy, 2021
Orfali, Nina, Mokhtar, Asmaa E., Guarneri, Danielle, Hsu, Jingmei, Phillips, Adrienne, Gergis, Usama, Shore, Tsiporah B., Mayer, Sebastian, Van Besien, Koen, Seven Years of Haplo-Cord Transplantation: Immune Reconstitution and Outcomes Using Anti-Thymocyte Globulin, Biology of Blood and Marrow Transplantation, 26, (3), 2020, pS309
Salvatore M., Laplante J.M., Soave R., Orfali N., Plate M., van Besien K., St. George K., Baloxavir for the treatment of Influenza in allogeneic hematopoietic stem cell transplant recipients previously treated with oseltamivir, Transplant Infectious Disease, 22, (4), 2020
Orfali N., O'Donovan T.R., Cahill M.R., Benjamin D., Nanus D.M., McKenna S.L., Gudas L.J., Mongan N.P., All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL), European Journal of Haematology, 104, (3), 2020, p236 - 250, p236-250
Brian J. Chernak and Emily Coskun and Nina Orfali and Yuqing Qiu and Rosemary Soave and Tsiporah B. Shore and Koen van Besien and Mirella Salvatore, Clinical Characteristics and Risk Factors for Adverse Outcomes of Influenza Infections in Hematopoietic Stem Cell Transplant Recipients, Blood, 136, (Supplement 1), 2020, p22--22
Orfali N., Shan-Krauer D., O'Donovan T.R., Mongan N.P., Gudas L.J., Cahill M.R., Tschan M.P., McKenna S.L., Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells, Molecular Oncology, 14, (6), 2020, p1297 - 1309, p1297-1309
Chaekal O.-K., Scaradavou A., Frenet E.M., Albano M.S., Cushing M., Desai P., Dobrila L., Gergis U., Guarneri D., Hsu J.-M., Lee S., Mayer S.A., Phillips A.A., Orfali N., Ritchie E.K., Roboz G.J., Romeo C., Samuel M.S., Shore T., van Besien K., Adoptive immunotherapy with CB following chemotherapy for patients with refractory myeloid malignancy: chimerism and response, Blood Advances, 4, (20), 2020, p5146 - 5156, p5146-5156
Van Besien K., Orfali N., Shore T., Allogeneic Transplant Conditioning Regimens for Patients with Non-Hodgkin Lymphoma, JAMA Oncology, 6, (12), 2020, p1980-
Gomez-Arteaga A., Orfali N., Guarneri D., Cushing M.M., Gergis U., Hsu J., Hsu Y.-M.S., Mayer S.A., Phillips A.A., Chase S.A., Mokhtar A.E., Shore T.B., Van Besien K., Cord blood transplants supported by unrelated donor CD34+ progenitor cells, Bone Marrow Transplantation, 55, (12), 2020, p2298 - 2307, p2298-2307
Van Besien K.W., Orfali N., Alternative donor transplantation for lymphoid malignancies: How far we have come, Journal of Clinical Oncology, 38, (14), 2020, p1501 - 1504, p1501-1504
Orfali N., van Besien K., Combining haplo-identical and cord blood stem cell grafts"might the whole be greater than the sum of its parts?, Leukemia and Lymphoma, 61, (4), 2020, p753 - 756, p753-756
Alexandra Gomez-Arteaga and Nina Orfali and Danielle Guarneri and Usama Gergis and Sebastian A. Mayer and Jingmei Hsu and Adrienne A. Phillips and Tsiporah B. Shore and Koen Van Besien, Disease Risk Index (DRI) and Age but Not HCT Comorbidity Index (HCT-CI) Are Predictive of Overall Survival after Cord Blood Transplantation Supported By Haplo-CD34+ progenitor Cells, Blood, 134, (Supplement{\_), 2019, p2040--2040
Nina Orfali and Alexandra Gomez-Arteaga and Danielle Guarneri and Jingmei Hsu and Adrienne A. Phillips and Usama Gergis and Tsiporah B. Shore and Sebastian A. Mayer and Koen Van Besien, Haplo-Cord Transplantation with Anti-Thymocyte Globulin: Comparative Clinical Outcomes with or without Routine G-CSF Administration, Blood, 134, (Supplement{\_), 2019, p2000--2000
Orfali N., Jeyapalan J.N., Woodcock C.L., O'Donovan T.R., Benjamin D., Cahill M., McKenna S., Gudas L.J., Mongan N.P., Lentiviral-Mediated shRNA Approaches: Applications in Cellular Differentiation and Autophagy, Methods in Molecular Biology, 2019, 2019, p33 - 49, p33-49
Orfali N., O'Donovan T.R., Nyhan M.J., Britschgi A., Tschan M.P., Cahill M.R., Mongan N.P., Gudas L.J., McKenna S.L., Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation, Experimental Hematology, 43, (9), 2015, p781 - 793.e2, p781-793.e2
Orfali N., McKenna S.L., Cahill M.R., Gudas L.J., Mongan N.P., Retinoid receptor signaling and autophagy in acute promyelocytic leukemia, Experimental Cell Research, 324, (1), 2014, p1 - 12, p1-12
Orfali, Nina M., Mongan, Nigel P., Cahill, Mary R., McKenna, Sharon L., Gudas, Lorraine J., ATRA-Induced Activation of the Autophagy Regulator Tfeb Regulates Myeloid Differentiation in Acute Promyelocytic Leukemia, Blood, 124, (21), 2014, p1057-1057
Nyhan, M., Elzinga, B., Crowley, L., O'Donovan, T., Orfali, N., O'Sullivan, G. C., Cahill, M., McKenna, S. L., Induction of Autophagy by Imatinib Sequesters BCR-ABL in Autophagosomes and Reduces BCR-ABL Expression, European Journal of Cancer, 48, 2012, p30
Orfali, Nina M., O'Donovan, Tracey, Nyhan, Michelle, Mongan, Nigel P, Gudas, Lorraine J, Cahill, Mary R, McKenna, Sharon, Autophagy As a Target for Differentiation Therapy in Acute Myeloid Leukemia., Blood, 120, (21), 2012, p2464-2464
Kloesel B., Musibay E.D., Pedersen K., Orfali N., Mattingley J., Vassallo R., A 64-year-old man with progressive dyspnea and cough productive of copious amounts of clear sputum, Chest, 141, (6), 2012, p1622 - 1625, p1622-1625