Publications and Further Research Outputs
Peer-Reviewed Publications
Bertrand A, Sugrue J, Lou T, Bourke N.M, Quintana-Murci L, Saint-André V, O'Farrelly C, Duffy D, Impact of socioeconomic status on healthy immune responses in humans, Immunology and Cell Biology, 2024
Laura Morrison, Adam H Dyer, Helena Dolphin, Isabelle Killane, Nollaig M Bourke, Matthew Widdowson, Conor P Woods, James Gibney, Richard B Reilly, Sean P Kennelly, Discrete Relationships between Spatiotemporal Gait Characteristics and Domain-Specific Neuropsychological Performance in Midlife, Sensors, 2024
L Morrison, AH Dyer, H Dolphin, I Batten, C Reddy, M Widdowson, CP Woods, J Gibney, NM Bourke, SP Kennelly, Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes, Brain, Behavior, & Immunity - Health, 41, (November), 2024, p100862-
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Aoife Fallon, Sean O'Dowd, Nollaig M Bourke, Sean P Kennelly, Performance of plasma p-tau217 for the detection of amyloid-ß positivity in a memory clinic cohort using an electrochemiluminescence immunoassay, Alzheimer's Research & Therapy, 2024
Fung Ka Yee, de Geus Eveline D, Ying Le, Cumming Helen, Bourke Nollaig, Foster Samuel C, Hertzog Paul J, Expression of Interferon Epsilon in Mucosal Epithelium is Regulated by Elf3 , Molecular and cellular biology , 44 , (8 ), 2024, p334 - 343
Dyer AH, Dolphin H, McElheron M, Bourke NM, Kennelly SP, Moving from "vulnerability" to "inter-individual variability" in defining a place for the biology of ageing in geriatric medicine., European geriatric medicine, 2023
Marks Zoe R C, Campbell Nicole K, Mangan Niamh E, Vandenberg Cassandra J, Gearing Linden J, Matthews Antony Y, Gould Jodee A, Tate Michelle D, Wray-McCann Georgie, Ying Le, Rosli Sarah, Brockwell Natasha, Parker Belinda S, Lim San S, Bilandzic Maree, Christie Elizabeth L, Stephens Andrew N, de Geus Eveline, Wakefield Matthew J, Ho Gwo-Yaw, McNally Orla, =Australian Ovarian Cancer Study, McNeish Iain A, Bowtell David D L, de Weerd Nicole A, Scott Clare L, Bourke Nollaig M, Hertzog Paul J, Interferon-" is a tumour suppressor and restricts ovarian cancer , Nature , 620 , (7976 ), 2023, p1063 - 1070
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023
Gordon Greville, Sinead Cremen, Shauna O'Neill, Sarah Azarian, Gareth Brady, William McCormack, Adam H Dyer, Nollaig M Bourke, Olivier Touzelet, David Courtney, Ultan F Power, Paul Dowling, Tom K Gallagher, Connor G G Bamford, Mark W Robinson, Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis, Clin Exp Immunol ., 2023
Laird Eamon, O'Halloran Aisling M, Molloy Anne M, Healy Martin, Bourke Nollaig, Kenny Rose Anne, Vitamin D status & associations with inflammation in older adults , PloS one , 18 , (6 ), 2023, pe0287169 -
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Emily Killeen, Conal Gallagher, Naomi Davey, Eimear Connolly, Shane Lyons, Conor Young, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Nollaig M Bourke, Aoife Fallon, Sean O'Dowd, Sean P Kennelly, Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration, BMJ Open, 2023
Caron, Barthelemy and Patin, Etienne and Rotival, Maxime and Charbit, Bruno and Albert, Matthew L and Quintana-Murci, Lluis and Duffy, Darragh and Rausell, Antonio and {Milieu Intérieur Consortium, Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes, Genome medicine, 14, (1), 2022, p28
Dyer AH, Batten I, Reddy C, Townsend L, Woods CP, O'Neill D, Gibney J, Kennelly SP, Bourke NM, Neuropsychological Decrements in Midlife Type-2 Diabetes are Not Associated with Peripheral NLRP3 Inflammasome Responsiveness, Frontiers in Immunology, 2022
Sugrue JA, Posseme C, Tan Z, Pou C, Charbit B, Bondet V, Bourke NM, Brodin P, Duffy D, O'Farrelly C, Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort., Cell reports. Medicine, 2022
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari FS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Erikstrup C, Condino-Neto A, Prando C, Bondarenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest Group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CP-COVID-19 Group, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement Français du Sang Study group, Anderson MS, Boisson B, Béziat V, Zhang SY, Andreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Burdet C, Bouadma L, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Casanova JL, Abel L, Cobat A., The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies., Proceedings of the National Academy of Sciences of the United States of America, 119, (21), 2022, pe2200413119
Dyer A, Noonan C, Pierpoint R, Leonard A, Boran G, Brady G, Fallon A, O'Farrelly C, Bourke N, Kennelly, 953 PREVIOUS SARS-COV2 INFECTION, AGE AND FRAILTY PREDICT 6-MONTH BNT162B2 VACCINE-INDUCED ANTIBODY TITRE IN NURSING HOME RESIDENTS, Age and ageing, 2022
Bourke NM, Achilles SL, Huang SU, Cumming HE, Lim SS, Papageorgiou I, Gearing LJ, Chapman R, Thakore S, Mangan NE, Mesiano S, Hertzog PJ, Spatiotemporal regulation of human IFN" and innate immunity in the female reproductive tract., JCI insight, 2022
Bergstedt J, Azzou SAK, Tsuo K, Jaquaniello A, Urrutia A, Rotival M, Lin DTS, MacIsaac JL, Kobor MS, Albert ML, Duffy D, Patin E, Quintana-Murci L, Milieu Intérieur Consortium, The immune factors driving DNA methylation variation in human blood., Nature communications, 2022
Posseme, Celine and Llibre, Alba and Charbit, Bruno and Bondet, Vincent and Rouilly, Vincent and Saint-André, Violaine and Boussier, Jeremy and Bergstedt, Jacob and Smith, Nikaïa and Townsend, Liam and Sugrue, Jamie A and Nà Cheallaigh, ClÃona and Conlon, Niall and Rotival, Maxime and Kobor, Michael S and Mottez, Estelle and Pol, Stanislas and Patin, Etienne and Albert, Matthew L and Quintana-Murci, Lluis and Duffy, Darragh and {Milieu Intérieur Consortium, Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation, Cell reports, 39, (13), 2022, p110989
Bourke, Nollaig M and Achilles, Sharon L and Huang, Stephanie U-Shane and Cumming, Helen E and Lim, San S and Papageorgiou, Irene and Gearing, Linden J and Chapman, Ross and Thakore, Suruchi and Mangan, Niamh E and Mesiano, Sam and Hertzog, Paul J, Spatiotemporal regulation of human IFNε and innate immunity in the female reproductive tract, JCI insight, 2022, pe135407
Dyer AH, Noonan C, McElheron M, Batten I, Reddy C, Connolly E, Pierpoint R, Murray C, Leonard A, Higgins C, Reilly P, Boran G, Phelan T, McCormack W, O'Neill D, Fallon A, Brady G, O'Farrelly C, Bourke NM, Kennelly SP., Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents, Journal of the American Medical Directors Association, 2022
Duffy D, SMITH N, Possémé C, Bondet V, Sugrue J, Townsend L, Charbit B, Rouilly V, Saint-André V, Dott T, Pozo AR, Yatim N, Schwartz O, Bourke N, Defective type I interferon immunity is associated with increasing COVID-19 severity, 2022
Smith N, Possémé C, Bondet V, Sugrue J, Townsend L, Charbit B, Rouilly V, Saint-André V, Dott T, Pozo AR, Yatim N, Schwartz O, Cervantes-Gonzalez M, Ghosn J, Bastard P, Casanova JL, Szwebel TA, Terrier B, Conlon N, O'Farrelly C, Cheallaigh CN, Bourke NM, Duffy D., Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity., Nature communications, 13, (1), 2022, p7254
Dyer AH, Fallon A, Noonan C, Dolphin H, O'Farrelly C, Bourke NM, O'Neill D, Kennelly SP, Managing The Impact Of COVID-19 in Nursing Homes and Long-Term Care Facilities: An Update, Journal of the American Medical Directors Association, 2022
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236
Townsend L, Dowds J, O'Brien K, Sheill G, Dyer AH, O'Kelly B, Hynes JP, Mooney A, Dunne J, Ni Cheallaigh C, O'Farrelly C, Bourke NM, Conlon N, Martin-Loeches I, Bergin C, Nadarajan P, Bannan C., Persistent Poor Health Post-COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity., Annals of the American Thoracic Society, 2021
Liam Townsend, Adam H Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig Bourke, Niall Conlon, Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health, Frontiers In Immunology, 2021
Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021
Dyer A, Townsend L, Naughton A, Kiersey R, Holden D, Gardiner M, Dunne J, O'Farrelly C, Cheallaigh C, Conlon N, Bourke N, 42 EXPLORING THE IMPACT OF AGE AND FRAILTY STATUS ON THE IMMUNE RESPONSE TO COVID-19 ILLNESS USING DETAILED IMMUNO-PHENOTYPING, Age and ageing, 2021
Liam Townsend, Adam H. Dyer, Patrick McCluskey, Kate O"Brien, Joanne Dowds, Eamon Laird, Ciaran Bannan, Nollaig M. Bourke, Cliona Ní Cheallaigh, Declan G. Byrne, Rose Anne Kenny, Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection, Nutrients, 13, (7), 2021, p2430
Jamie A. Sugrue, Megan Smith, Celine Posseme, Bruno Charbit, Nollaig M. Bourke, Darragh Duffy, Cliona O"Farrelly, Rhesus negative males have an enhanced IFN"-mediated immune response to influenza A virus, 2021
Batten I., Robinson M. W., White A., Walsh C., Fazekas B., Wyse J., Buettner A., D'Arcy S., Greenan E., Murphy C. C., Wigston Z., Gabhann-Dromgoole J. N., Vital E. M., Little M. A., Bourke N. M., Investigation of type I interferon responses in ANCA-associated vasculitis., Scientific reports, 11, (1), 2021, p8272
Bastard, Paul and Gervais, Adrian and Le Voyer, Tom and Rosain, Jérémie and Philippot, Quentin and Manry, Jérémy and Michailidis, Eleftherios and Hoffmann, Hans-Heinrich and Eto, Shohei and Garcia-Prat, Marina and Bizien, Lucy and Parra-MartÃnez, Alba and Yang, Rui and HaljasmÀgi, Liis and Migaud, Mélanie and SÀrekannu, Karita and Maslovskaja, Julia and de Prost, Nicolas and Tandjaoui-Lambiotte, Yacine and Luyt, Charles-Edouard and Amador-Borrero, Blanca and Gaudet, Alexandre and Poissy, Julien and Morel, Pascal and Richard, Pascale and Cognasse, Fabrice and Troya, Jesus and Trouillet-Assant, Sophie and Belot, Alexandre and Saker, Kahina and Garçon, Pierre and RiviÚre, Jacques G and Lagier, Jean-Christophe and Gentile, Stéphanie and Rosen, Lindsey B and Shaw, Elana and Morio, Tomohiro and Tanaka, Junko and Dalmau, David and Tharaux, Pierre-Louis and Sene, Damien and Stepanian, Alain and Megarbane, Bruno and Triantafyllia, Vasiliki and Fekkar, Arnaud and Heath, James R and Franco, José Luis and Anaya, Juan-Manuel and Solé-Violán, Jordi and Imberti, Luisa and Biondi, Andrea and Bonfanti, Paolo and Castagnoli, Riccardo and Delmonte, Ottavia M and Zhang, Yu and Snow, Andrew L and Holland, Steven M and Biggs, Catherine and Moncada-Vélez, Marcela and Arias, Andrés Augusto and Lorenzo, Lazaro and Boucherit, Soraya and Coulibaly, Boubacar and Anglicheau, Dany and Planas, Anna M and Haerynck, Filomeen and Duvlis, Sotirija and Nussbaum, Robert L and Ozcelik, Tayfun and Keles, Sevgi and Bousfiha, Ahmed A and El Bakkouri, Jalila and Ramirez-Santana, Carolina and Paul, Stéphane and Pan-Hammarström, Qiang and Hammarström, Lennart and Dupont, Annabelle and Kurolap, Alina and Metz, Christine N and Aiuti, Alessandro and Casari, Giorgio and Lampasona, Vito and Ciceri, Fabio and Barreiros, Lucila A and Dominguez-Garrido, Elena and Vidigal, Mateus and Zatz, Mayana and van de Beek, Diederik and Sahanic, Sabina and Tancevski, Ivan and Stepanovskyy, Yurii and Boyarchuk, Oksana and Nukui, Yoko and Tsumura, Miyuki and Vidaur, Loreto and Tangye, Stuart G and Burrel, Sonia and Duffy, Darragh and Quintana-Murci, Lluis and Klocperk, Adam and Kann, Nelli Y and Shcherbina, Anna and Lau, Yu-Lung and Leung, Daniel and Coulongeat, Matthieu and Marlet, Julien and Koning, Rutger and Reyes, Luis Felipe and Chauvineau-Grenier, Angélique and Venet, Fabienne and Monneret, Guillaume and Nussenzweig, Michel C and Arrestier, Romain and Boudhabhay, Idris and Baris-Feldman, Hagit and Hagin, David and Wauters, Joost and Meyts, Isabelle and Dyer, Adam H and Kennelly, Sean P and Bourke, Nollaig M and Halwani, Rabih and Sharif-Askari, Narjes Saheb and Dorgham, Karim and Sallette, Jérome and Sedkaoui, Souad Mehlal and AlKhater, Suzan and Rigo-Bonnin, Raúl and Morandeira, Francisco and Roussel, Lucie and Vinh, Donald C and Ostrowski, Sisse Rye and Condino-Neto, Antonio and Prando, Carolina and Bonradenko, Anastasiia and Spaan, András N and Gilardin, Laurent and Fellay, Jacques and Lyonnet, Stanislas and Bilguvar, Kaya and Lifton, Richard P and Mane, Shrikant and {HGID Lab, Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths, Science immunology, 6, (62), 2021, peabl4340
Sugrue JA, Bourke NM, O'Farrelly C., Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature., Frontiers in immunology, 12, 2021, p757249
Dyer A, McKenna L, Gamage G, Bourke N, Killane I, Widdowson M, Woods C, Gibney J, Reilly R, O'Neill D, Kennelly S. , Cognitive performance in midlife type 2 diabetes: results from the ENBIND study, Diabetic Medicine, 2020
Dyer AH, McKenna L, Batten I, Jones K, Widdowson M, Dunne J, Conlon N, Reilly R, Woods CP, O'Neill D, Gibney J, Bourke NM, Kennelly SP., Peripheral Inflammation and Cognitive Performance in Middle-Aged Adults With and Without Type 2 Diabetes: Results From the ENBIND Study, Front. Aging Neurosci, 12, 2020
Liam Townsend, Adam H Dyer, Karen Jones, Jean Dunne, Rachel Kiersey, Fiona Gaffney, Laura O'Connor, Aoife Mooney, Deirdre Leavy, Katie Ridge, Catherine King, Fionnuala Cox, Kate O'Brien, Joanne Dowds, Jamie Sugrue, David Hopkins, Patricia Byrne, Tara Kingston, Cliona Ni Cheallaigh, Parthiban Nadarajan, Anne Marie McLaughlin, Nollaig M Bourke, Colm Bergin, Cliona O'Farrelly, Ciaran Bannan, Niall Conlon, Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection, PloS One, 2020
Adam Dyer, Isabella Batten, Isabelle Killane, Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Nollaig Bourke, Sean Kennelly, 85 Linking Diabetes and Dementia Risk: A Role for Aß-42 Induced Activation of the NLRP3 Inflammasome? Results from the ENBIND Study, 48, (Supplement{\_), 2019, ppiii17--iii65
Jennifer K. Dowling, Michelle D. Tate, Sarah Rosli, Nollaig M. Bourke, Natalie Bitto, Mario A. Lauterbach, Shane Cheung, Thomas Ve, Bostjan Kobe, Douglas Golenbock, Ashley Mansell, The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses, The Journal of Immunology, 2019, pji1800501
Adam Dyer, Isabelle Killane, Nollaig Bourke, Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Sean Kennelly, 84 Does Dual-Task Gait Speed Predict Cognitive Performance in Midlife Type 2 Diabetes? Baseline Results from the ENBIND Study, 48, (Supplement{\_), 2019, ppiii1--iii16
Layte, R. and McCrory, C., Ni Cheallaigh, C., Bourke, N., Kivimaki, M., Ribeiro, A.I, Stringhini, S. and Vineis, P., A Comparative Analysis of the Status Anxiety Hypothesis of Socio-Economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies, Scientific Reports, Online, 2019, p1 - 6
Marks ZRC, Campbell N, deWeerd NA, Lim SS, Gearing LJ, Bourke NM, Hertzog PJ., PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON., Seminars in immunology, 2019, p101328
Cathal McCrory, Giovanni Fiorito, Sinead McLoughlin, Silvia Polidoro, Cliona Ni Cheallaigh, Nollaig Bourke, Piia Karisola, Harri Alenius, Paolo Vineis, Richard Layte, Rose Anne Kenny, Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological ageing, Journal of Gerontology: Biological Sciences, 2019
Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight à , Stevenson NJ., Control of HIV infection by IFN-alpha: implications for latency and a cure., Cellular and molecular life sciences : CMLS, 75, (5), 2018, p775-783
Cumming HE, Bourke NM, Type I IFNs in the female reproductive tract: The first line of defense in an ever-changing battleground., Journal of leukocyte biology, 2018
Nollaig M Bourke, Sharon L Achilles, Stephanie U Huang, Helen E Cumming, Irene Papageorgio, Linden J Gearing, Suruchi Thakore, Niamh E Mangan, Sam Mesiano, Paul J Hertzog, Human IFN": Spaciotemporal expression, hormone regulation and innate immunity in the female reproductive tract, 2018
de Weerd NA, Matthews AY, Pattie PR, Bourke NM, Lim SS, Vivian JP, Rossjohn J, Hertzog PJ., A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling., The Journal of Biological Chemistry, 292, (18), 2017, p7554 - 7565
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764
New Interferons in, editor(s)Michael J. H. Ratcliffe , Encyclopedia of Immunobiology, Elsevier, 2016, pp501 - 508, [Paul J. Hertzog, Nollaig M. Bourke, Nicole A. de Weerd, Niamh E. Mangan]
Klionsky et al, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)., Autophagy, 12, (1), 2016, p1 - 122
Niamh E Mangan, Nollaig Bourke, Caroline Gargett, Paul J. Hertzog, 125, 70, (1), 2014, pp58
Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437
Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-
Niamh E. Mangan, Nollaig Bourke, Ka Yee Fung, Sebastian Stifter, Caroline Gargett, Paul J. Hertzog, 175, 63, (3), 2013, pp284
Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578
Leonie Unterholzner, Rebecca P. Sumner, Marcin Baran, Hongwei Ren, Daniel S. Mansur, Nollaig M. Bourke, Felix Randow, Geoffrey L. Smith, Andrew G. Bowie, Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7, PLoS Pathogens, 7, (9, e1002247), 2011
Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866
Non-Peer-Reviewed Publications
Ann Monaghan, Nollaig Bourke, Aisling O'Halloran, Mark Ward, Feng Xue, Glenn Jennings, Rose Anne Kenny and Roman Romero-Ortuno, New self-reported exhaustion during the COVID-19 Pandemic, TILDA Report, 2021
De Looze, C., Ward, M., McDowell, C., Bourke, N., Kenny R.A., Preparing for COVID-19 vaccination: important learnings from the Irish Longitudinal Study on Ageing (TILDA), Dublin, TILDA, December, 2020
Research Expertise
Description
My research focuses on understanding how the immune system changes with age and the role immune dysregulation plays in age-related disease initiation and pathology. In particular, I am interested in investigating how the initiation and regulation of innate immune responses, such as inflammation and anti-viral immunity, change with age, with a focus on how these processed are related to biological ageing and age-associated physiological decline.Recognition
Memberships
Irish Society of Immunology
Society for Mucosal Immunology
International Cytokine and Interferon Society (ICIS)
Victorian Infection and Immunity Network, Australia
Australian Centre for HIV and Hepatitis Virology Research (ACH2)