Professor Mark Cunningham
Professor of Neurophysiology of Epilepsy, Physiology
Publications and Further Research Outputs
Peer-Reviewed Publications
Spedding, M. and Sebban, C. and Jay, T.M. and Rocher, C. and Tesolin-Decros, B. and Chazot, P. and Schenker, E. and Sz{\'e, Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile, Cells, 11, (7), 2022
Cunningham MO., Cross Talk proposal: Human-derived brain tissue is a better epilepsy model than animal-based approaches., The Journal of physiology, 600, (21), 2022, p4569-4574
Zaaimi B, Turnbull M, Hazra A, Wang Y, Gandara C, McLeod F, McDermott EE, Escobedo-Cousin E, Idil AS, Bailey RG, Tardio S, Patel A, Ponon N, Gausden J, Walsh D, Hutchings F, Kaiser M, Cunningham MO, Clowry GJ, LeBeau FEN, Constandinou TG, Baker SN, Donaldson N, Degenaar P, O'Neill A, Trevelyan AJ, Jackson A., Closed-loop optogenetic control of the dynamics of neural activity in non-human primates., Nature biomedical engineering, 2022
Morris, G. and Langa, E. and Fearon, C. and Conboy, K. and Lau E-How, K. and Sanz-Rodriguez, A. and O{', MicroRNA inhibition using antimiRs in acute human brain tissue sections, Epilepsia, 63, (8), 2022, pe92-e99
Brito da Silva, A. and Pennifold, J. and Henley, B. and Chatterjee, K. and Bateman, D. and Whittaker, R.W. and Joshi, A. and Kumar, H. and Nicholson, C. and Baker, M.R. and Greenhill, S.D. and Walsh, R. and Seri, S. and Jones, R.S.G. and Woodhall, G.L. and Cunningham, M., The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia, Epilepsia Open, 7, (3), 2022, p488-495
Nogueira, G.O. and Garcez, P.P. and Bardy, C. and Cunningham, M.O. and Sebollela, A., Modeling the Human Brain With ex vivo Slices and in vitro Organoids for Translational Neuroscience, Frontiers in Neuroscience, 16, 2022
Lopez-Rodriguez, A.B. and Hennessy, E. and Murray, C.L. and Nazmi, A. and Delaney, H.J. and Healy, D. and Fagan, S.G. and Rooney, M. and Stewart, E. and Lewis, A. and de Barra, N. and Scarry, P. and Riggs-Miller, L. and Boche, D. and Cunningham, M.O. and Cunningham, C., Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction, Alzheimer's and Dementia, 17, (10), 2021, p1735-1755
Morris G and Rowell R and Cunningham M, Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?, ALTEX, 2021
Chan F, Lax NZ, Voss CM, Aldana BI, Whyte S, Jenkins A, Nicholson C, Nichols S, Tilley E, Powell Z, Waagepetersen HS, Davies CH, Turnbull DM, Cunningham MO, The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction, Brain, 142, (2), 2019, p391 - 411
Sánchez RG, Parrish RR, Rich M, Webb WM, Lockhart RM, Nakao K, Ianov L, Buckingham SC, Broadwater DR, Jenkins A, de Lanerolle NC, Cunningham M, Eid T, Riley K, Lubin FD., Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity., Neurobiology of disease, 124, 2019, p531-543
Stone TJ, Rowell R, Jayasekera BAP, Cunningham MO, Jacques TS, Review: Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE)., Neuropathology and applied neurobiology, 2018
Augustin K, Williams S, Cunningham M, Devlin AM, Friedrich M, Jayasekera A, Hussain MA, Holliman D, Mitchell P, Jenkins A, Chen PE, Walker MC, Williams RSB., Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures., Epilepsia, 59, (11), 2018, pe172-e178
Simpson AJ, Cunningham MO, Baker MR, Electrodiagnostic applications of somatosensory evoked high-frequency EEG oscillations: Technical considerations., Brain research bulletin, 2018
Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA, Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike-and-wave-like electrographic events in vitro., Journal of neurophysiology, 2018
Ramezani R, Liu Y, Dehkhoda F, Soltan A, Haci D, Zhao H, Firfilionis D, Hazra A, Cunningham MO, Jackson A, Constandinou TG, Degenaar P, On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation., IEEE transactions on biomedical circuits and systems, 2018
Serrats J, Cunningham MO, Davies CH, GABAB receptor modulation-to B or not to be B a pro-cognitive medicine?, Current opinion in pharmacology, 2017
Dheerendra P, Lynch NM, Crutwell J, Cunningham MO, Smulders TV, In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick., The European journal of neuroscience, 2017
Felix Chan, Nichola Z. Lax, Ceri H. Davies, Douglass M. Turnbull, Mark O. Cunningham, Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?, Neuropharmacology, 102, 2016, p48--58
Jones RS, da Silva AB, Whittaker RG, Woodhall GL, Cunningham MO, Human brain slices for epilepsy research: Pitfalls, solutions and future challenges., Journal of neuroscience methods, 2016
Lax NZ, Grady J, Laude A, Chan F, Hepplewhite PD, Gorman G, Whittaker RG, Ng Y, Cunningham MO, Turnbull DM, Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease., Neuropathology and applied neurobiology, 2016
Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Kheirollahi-Chadegani M, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Elliott DJ, A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior., Cell reports, 2016
Tomsett RJ, Ainsworth M, Thiele A, Sanayei M, Chen X, Gieselmann MA, Whittington MA, Cunningham MO, Kaiser M, Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue., Brain structure & function, 2015
Tsintsadze V, Minlebaev M, Suchkov D, Cunningham MO, Khazipov R, Ontogeny of kainate-induced gamma oscillations in the rat CA3 hippocampus in vitro., Frontiers in cellular neuroscience, 2015
Alfonsa H, Merricks EM, Codadu NK, Cunningham MO, Deisseroth K, Racca C, Trevelyan AJ, The contribution of raised intraneuronal chloride to epileptic network activity., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015
Whittaker RG, Devine HE, Gorman GS, Schaefer AM, Horvath R, Ng Y, Nesbitt V, Lax NZ, McFarland R, Cunningham MO, Taylor RW, Turnbull DM, Epilepsy in adults with mitochondrial disease: A cohort study., Annals of neurology, 2015
Cowie CJ, Cunningham MO, Peritumoral epilepsy: relating form and function for surgical success., Epilepsy & behavior : E&B, 2014
Tomsett RJ, Ainsworth M, Thiele A, Sanayei M, Chen X, Gieselmann A, Whittington MA, Cunningham MO, Kaiser M, Modelling spatially realistic local field potentials in spiking neural networks using the VERTEX simulation tool., BMC neuroscience, 2014
Tomsett RJ, Ainsworth M, Thiele A, Sanayei M, Chen X, Gieselmann A, Whittington MA, Cunningham MO, Kaiser M, Modelling local field potential features during network gamma oscillations., BMC neuroscience, 2014
Traub RD, Cunningham MO, Whittington MA, What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain., Advances in experimental medicine and biology, 2014
Simon A, Traub RD, Vladimirov N, Jenkins A, Nicholson C, Whittaker RG, Schofield I, Clowry GJ, Cunningham MO, Whittington MA, Gap junction networks can generate both ripple-like and fast ripple-like oscillations., The European journal of neuroscience, 2014
Carracedo LM, Kjeldsen H, Cunnington L, Jenkins A, Schofield I, Cunningham MO, Davies CH, Traub RD, Whittington MA, A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013
Sedley W, Cunningham MO, Do cortical gamma oscillations promote or suppress perception? An under-asked question with an over-assumed answer., Frontiers in human neuroscience, 2013
Cunningham MO, Roopun A, Schofield IS, Whittaker RG, Duncan R, Russell A, Jenkins A, Nicholson C, Whittington MA, Traub RD, Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance., Epilepsia, 2012
Ainsworth M, Lee S, Cunningham MO, Traub RD, Kopell NJ, Whittington MA, Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks., Neuron, 2012
Randall FE, Whittington MA, Cunningham MO, Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro., The European journal of neuroscience, 2011
Whittaker RG, Turnbull DM, Whittington MA, Cunningham MO, Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons., Brain : a journal of neurology, 2011
Simonotto JD, Kaiser M, Whittington MA, Cunningham MO, Network properties of control and epileptic human slice recordings., BMC neuroscience, 2011
Ainsworth M, Lee S, Cunningham MO, Roopun AK, Traub RD, Kopell NJ, Whittington MA, Dual " rhythm generators control interlaminar synchrony in auditory cortex., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011
Cunningham MO, Chinnery PF, Mitochondria and cortical gamma oscillations: food for thought?, Brain : a journal of neurology, 2011
Whittington MA, Cunningham MO, LeBeau FE, Racca C, Traub RD, Multiple origins of the cortical " rhythm., Developmental neurobiology, 2011
Traub RD, Cunningham MO, Whittington MA, Chemical synaptic and gap junctional interactions between principal neurons: partners in epileptogenesis., Neural networks : the official journal of the International Neural Network Society, 2011
Traub RD, Duncan R, Russell AJ, Baldeweg T, Tu Y, Cunningham MO, Whittington MA, Spatiotemporal patterns of electrocorticographic very fast oscillations (> 80 Hz) consistent with a network model based on electrical coupling between principal neurons., Epilepsia, 2010
Roopun AK, Simonotto JD, Pierce ML, Jenkins A, Nicholson C, Schofield IS, Whittaker RG, Kaiser M, Whittington MA, Traub RD, Cunningham MO, A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex., Proceedings of the National Academy of Sciences of the United States of America, 2010
Roopun AK, Lebeau FE, Rammell J, Cunningham MO, Traub RD, Whittington MA, Cholinergic neuromodulation controls directed temporal communication in neocortex in vitro., Frontiers in Neural Circuits, 2010
Roopun AK, Traub RD, Baldeweg T, Cunningham MO, Whittaker RG, Trevelyan A, Duncan R, Russell AJ, Whittington MA, Detecting seizure origin using basic, multiscale population dynamic measures: preliminary findings., Epilepsy & behavior : E&B, 2009
Roopun AK, Cunningham MO, Racca C, Alter K, Traub RD, Whittington MA, Region-specific changes in gamma and beta2 rhythms in NMDA receptor dysfunction models of schizophrenia., Schizophrenia Bulletin, 2008
Middleton S, Jalics J, Kispersky T, Lebeau FE, Roopun AK, Kopell NJ, Whittington MA, Cunningham MO, NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex., Proceedings of the National Academy of Sciences of the United States of America, 2008
Stanger HL, Alford R, Jane DE, Cunningham MO, The role of GLU K5-containing kainate receptors in entorhinal cortex gamma frequency oscillations., Neural Plasticity, 2008
Middleton SJ, Racca C, Cunningham MO, Traub RD, Monyer H, Knöpfel T, Schofield IS, Jenkins A, Whittington MA, High-frequency network oscillations in cerebellar cortex., Neuron, 2008
Fuchs EC, Zivkovic AR, Cunningham MO, Middleton S, Lebeau FE, Bannerman DM, Rozov A, Whittington MA, Traub RD, Rawlins JN, Monyer H, Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior., Neuron, 2007
Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, LeBeau FE, Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)., The European journal of neuroscience, 2007
Cunningham MO, Hunt J, Middleton S, LeBeau FE, Gillies MJ, Davies CH, Maycox PR, Whittington MA, Racca C, Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006
Roopun AK, Middleton SJ, Cunningham MO, LeBeau FE, Bibbig A, Whittington MA, Traub RD, A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex., Proceedings of the National Academy of Sciences of the United States of America, 2006
Pervouchine DD, Netoff TI, Rotstein HG, White JA, Cunningham MO, Whittington MA, Kopell NJ, Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus., Neural computation, 2006
Cunningham MO, Pervouchine DD, Racca C, Kopell NJ, Davies CH, Jones RS, Traub RD, Whittington MA, Neuronal metabolism governs cortical network response state., Proceedings of the National Academy of Sciences of the United States of America, 2006
Traub RD, Bibbig A, LeBeau FE, Cunningham MO, Whittington MA, Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model., The Journal of physiology, 2005
Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FE, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA, Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts., Journal of neurophysiology, 2005
Cunningham MO, Woodhall GL, Thompson SE, Dooley DJ, Jones RS, Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro., The European journal of neuroscience, 2004
Cunningham MO, Halliday DM, Davies CH, Traub RD, Buhl EH, Whittington MA, Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro., The Journal of physiology, 2004
Cunningham MO, Whittington MA, Bibbig A, Roopun A, LeBeau FE, Vogt A, Monyer H, Buhl EH, Traub RD, A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro., Proceedings of the National Academy of Sciences of the United States of America, 2004
Cunningham MO, Woodhall GL, Jones RS, Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro., Neuropharmacology, 2003
Roger D. Traub and Miles A. Whittington and Mark O. Cunningham, Simulation of oscillatory dynamics induced by an approximation of grid cell output, Reviews in the Neurosciences, 0, (0)
Stephen Hall and Karen Hawkins and Grace Laws and Thomas Akitt and Anna Simon and Ceri H. Davies and Miles A. Whittington and Mark O. Cunningham, Cross-fostering in rodents causes region-specific alterations in entorhinal cortical gamma rhythms associated with {NMDA
Richard G. Sanchez and R. Ryley Parrish and Megan Rich and William M. Webb and Roxanne M. Lockhart and Kazuhito Nakao and Lara Ianov and Susan C. Buckingham and Mark Cunningham and Devin R. Broadwater and Alistar Jenkins and Nihal C De Lanerolle and Tore Eid and Kristen Riley and Farah D. Lubin, Human and Rodent Temporal Lobe Epilepsy is Characterized by Changes in O-{GLCNAC
Research Expertise
Projects
- Title
- Gene Therapy approaches for brain tumour related epilepsy
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/11/21
- Date To
- 31/10/25
- Title
- Chicken Stress
- Funding Agency
- European Union Horizon 2020
- Date From
- 01/05/19
- Date To
- 30/04/23
- Title
- An examination of the impact of perampanel (Fycompa) on experimental models of cortical rhythms in vitro
- Funding Agency
- Eisai
- Date From
- 20/02/2020
- Date To
- 20/02/2024
- Title
- FutureNeuro Funded Investigator
- Funding Agency
- SFI
- Date From
- 20/02/2020
- Date To
- 20/02/2024
- Title
- Decoding the neuroinflammatory effects on neuronal circuits at the interface of dementia and delirium
- Funding Agency
- TCD
- Date From
- 01/09/2019
- Date To
- 31/08/2023
Recognition
Representations
Editorial Board member for Neuropharmacology (Elsevier)
Editorial Board member for Brain Research Bulletins (Elsevier)
Member of Scientific Advisory Committee for Epilepsy Resarch UK
Member of the Biomedical Resource and Technology Development Committee at the Wellcome Trust
Awards and Honours
EMBO Long-term fellowship
RCUK Academic Fellowship
Memberships
Membership of the British Neuroscience Association
Membership of The Physiological Society (UK)
Membership of the International League against Epilepsy (UK Chapter)