Professor Declan Mc Loughlin
Research Professor of Psychiatry, Psychiatry
Research Professor of Psychiatry, Trinity Inst. of Neurosciences (TCIN)
Biography
Declan M McLoughlin PhD MRCPI MRCPsych FTCD is Research Professor of Psychiatry in St Patrick's University Hospital and Trinity College Dublin, Ireland.
He qualified in Medicine from University College Dublin in 1986. After training in general medicine, he trained in Psychiatry, firstly in Dublin and then at the Maudsley Hospital and Institute of Psychiatry (IOP) in London. He obtained an Alzheimer's Society Training Fellowship (1994-1997) in the Dept of Neuroscience at the IOP, followed by a Wellcome Advanced Fellowship (1997-2000), during which time he was awarded a PhD in Molecular Neuroscience for his work on Alzheimer's disease APP-interacting proteins. After this he was appointed as a clinical Senior Lecturer and Consultant in Old Age Psychiatry in the Maudsley Hospital.
In 2007 he took up the new post of Research Professor of Psychiatry in Trinity College Dublin and St Patrick's University Hospital, where he is also a consultant in Old Age Psychiatry.
Recent research activities include: randomised controlled trials of ECT (EFFECT-Dep Study) and ketamine (KEEP-WELL, KARMA-Dep, KARMA-Dep 2) in severe depression; systematic reviews and meta-analyses; molecular biomarkers (e.g. mRNA, miRNA, telomere length) for depression; molecular mechanisms of action of ECT; and studies on the impact of the covid-19 pandemic on the well-being of health care workers (COWORKER). His work has been supported by the Alzheimer's Society, Wellcome Trust, NHS Health Technology Assessment Programme, NARSAD, and the Health Research Board.
Publications and Further Research Outputs
Peer-Reviewed Publications
Doody MRCPsych, Eimear, Ryan, Karen M., O'Toole MRCPsych, Clare, McLoughlin, Declan M., Telomere length in patients with anorexia nervosa, Psychiatry Research Communications, 2, (1), 2022, p100022
Meechan CF, Laws KR, Young AH, McLoughlin DM, Jauhar S., A critique of narrative reviews of the evidence-base for ECT in depression., Epidemiology and psychiatric sciences, 31, 2022, pe10
Rimmerman N, Verdiger H, Goldenberg H, Naggan L, Robinson E, Kozela E, Gelb S, Reshef R, Ryan KM, Ayoun L, Refaeli R, Ashkenazi E, Schottlender N, Ben Hemo-Cohen L, Pienica C, Aharonian M, Dinur E, Lazar K, McLoughlin DM, Zvi AB, Yirmiya R., Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation., Molecular psychiatry, 2021
Bauer M, Glenn T, Achtyes ED, Alda M, Agaoglu E, Alt"nba" K, Andreassen OA, Angelopoulos E, Ardau R, Vares EA, Aydin M, Ayhan Y, Baethge C, Bauer R, Baune BT, Balaban C, Becerra-Palars C, Behere AP, Behere PB, Belete H, Belete T, Belizario GO, Bellivier F, Belmaker RH, Benedetti F, Berk M, Bersudsky Y, Bicakci ", Birabwa-Oketcho H, Bjella TD, Brady C, Cabrera J, Cappucciati M, Castro AMP, Chen WL, Cheung EYW, Chiesa S, Crowe M, Cuomo A, Dallaspezia S, Del Zompo M, Desai P, Dodd S, Donix M, Etain B, Fagiolini A, Fellendorf FT, Ferensztajn-Rochowiak E, Fiedorowicz JG, Fountoulakis KN, Frye MA, Geoffroy PA, Gonzalez-Pinto A, Gottlieb JF, Grof P, Haarman BCM, Harima H, Hasse-Sousa M, Henry C, Høffding L, Houenou J, Imbesi M, Isometsä ET, Ivkovic M, Janno S, Johnsen S, Kapczinski F, Karakatsoulis GN, Kardell M, Kessing LV, Kim SJ, König B, Kot TL, Koval M, Kunz M, Lafer B, Landén M, Larsen ER, Lenger M, Lewitzka U, Licht RW, Lopez-Jaramillo C, MacKenzie A, Madsen HØ, Madsen SAKA, Mahadevan J, Mahardika A, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Martiny K, Mashima Y, McLoughlin DM, Meesters Y, Melle I, Meza-Urzúa F, Ming MY, Monteith S, Moorthy M, Morken G, Mosca E, Mozzhegorov AA, Munoz R, Mythri SV, Nacef F, Nadella RK, Nakanotani T, Nielsen RE, O'Donovan C, Omrani A, Osher Y, Ouali U, Pantovic-Stefanovic M, Pariwatcharakul P, Petite J, Pfennig A, Ruiz YP, Pilhatsch M, Pinna M, Pompili M, Porter R, Quiroz D, Rabelo-da-Ponte FD, Ramesar R, Rasgon N, Ratta-Apha W, Ratzenhofer M, Redahan M, Reddy MS, Reif A, Reininghaus EZ, Richards JG, Ritter P, Rybakowski JK, Sathyaputri L, Scippa ÂM, Simhandl C, Severus E, Smith D, Smith J, Stackhouse PW, Stein DJ, Stilwell K, Strejilevich S, Su KP, Subramaniam M, Sulaiman AH, Suominen K, Tanra AJ, Tatebayashi Y, Teh WL, Tondo L, Torrent C, Tuinstra D, Uchida T, Vaaler AE, Veeh J, Vieta E, Viswanath B, Yoldi-Negrete M, Yalcinkaya OK, Young AH, Zgueb Y, Whybrow PC., Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder., International journal of bipolar disorders, 9, (1), 2021, p26
Gallagher B, Neiman A, Slattery MC, McLoughlin DM., Online news media reporting of ketamine as a treatment for depression from 2000 to 2017., Irish journal of psychological medicine, 2021, p1-9
Loughran O, Finnegan M, Dud I, Galligan T, Kennedy M, McLoughlin DM., Decision-making Capacity for Treatment After Electroconvulsive Therapy for Depression., The journal of ECT, 2021
Jelovac A, Kolshus E, McLoughlin DM., Relapse following bitemporal and high-dose right unilateral electroconvulsive therapy for major depression., Acta psychiatrica Scandinavica, 144, (3), 2021, p218-229
Ryan KM, Finnegan M, Harkin A, McLoughlin DM., PBMC telomerase activity in depression and the response to electroconvulsive therapy., European archives of psychiatry and clinical neuroscience, 271, (7), 2021, p1297-1307
Fenton C, McLoughlin DM., Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy., PloS one, 16, (11), 2021, pe0259861
Luykx JJ, Loef D, Lin B, van Diermen L, Nuninga JO, van Exel E, Oudega ML, Rhebergen D, Schouws SNTM, van Eijndhoven P, Verwijk E, Schrijvers D, Birkenhager TK, Ryan KM, Arts B, van Bronswijk SC, Kenis G, Schurgers G, Baune BT, Arns M, van Dellen EE, Somers M, Sommer IEC, Boks MP, Gülöksüz S, McLoughlin DM, Dols A, Rutten BPF., Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness., Biological psychiatry, 2021
Kirov G, Jauhar S, Sienaert P, Kellner CH, McLoughlin DM., Electroconvulsive therapy for depression: 80 years of progress., The British journal of psychiatry : the journal of mental science, 219, (5), 2021, p594-597
Celine A. Fox, Declan M. McLoughlin, Speed of electroconvulsive therapy for depression: Effects of electrode placement, Acta Psychiatrica Scandinavica, 2021
Brady C, Fenton C Loughran O, Higgins A, McLoughlin D, Nursing home staff mental health during the Covid-19 pandemic in the Republic of Ireland, International Journal of Geriatric Psychiatry, 37, (1), 2021
Thekiso TB, McLoughlin DM, Hartnett Y, Casey S, Orji A, Heron EA, Rush G, Kennedy N., Outcome of First-admission Depression Treated in a Specialized Mood Disorders Service., Journal of psychiatric practice, 26, (6), 2020, p461-471
Alexander, Lauren, Kelly, Louisa, Doody, Eimear, Brady, Shane, Roddy, Darren, Counihan, Eimear, Delaney, Liam, McLoughlin, Declan, Malone, Kevin, Over the Cuckoo"s Nest, The Journal of ECT, 36, (3), 2020, p172-179
Bronagh Gallagher, Meabh Foley, Claire M. Slattery, Gabriele Gusciute, Enda Shanahan, Declan M. McLoughlin, Ketamine as an adjunctive therapy for major depression - a randomised controlled pragmatic pilot trial (Karma-Dep Trial), HRB Open Research, 3, 2020, p90
Short B, Dong V, Gálvez V, Vulovic V, Martin D, Bayes AJ, Zarate CA, Murrough JW, McLoughlin DM, Riva-Posse P, Schoevers R, Fraguas R, Glue P, Fam J, McShane R, Loo CK., Development of the Ketamine Side Effect Tool (KSET)., Journal of affective disorders, 266, 2020, p615-620
Ryan K.M., and Allers K.A. and Harkin A. and McLoughlin D.M. , Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy, Brain, Behavior and Immunity Health, 2020
Colbert SA, McCarron S, Ryan G, McLoughlin DM., Immediate Impact of Coronavirus Disease 2019 on Electroconvulsive Therapy Practice., The journal of ECT, 36, (2), 2020, p86-87
Ryan KM, Allers KA, McLoughlin DM, Harkin A., Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy., Brain, Behavior and Immunity, 83, 2020, p153 - 162
McGrory CL, Ryan KM, Gallagher B, McLoughlin DM., Vascular endothelial growth factor and pigment epithelial-derived factor in the peripheral response to ketamine., Journal of affective disorders, 273, 2020, p380-383
Alexander L, Kelly L, Doody E, Brady S, Roddy D, Counihan E, Delaney L, McLoughlin D, Malone K., Over the Cuckoo's Nest: Does Experiencing Electroconvulsive Therapy Change Your Mind? A Mixed Methods Study of Attitudes and Impact of Electroconvulsive Therapy on Patients and Their Relatives., The journal of ECT, 36, (3), 2020, p172-179
Read J, Cunliffe S, Jauhar S, McLoughlin DM., Should we stop using electroconvulsive therapy?, BMJ (Clinical research ed.), 364, 2019, pk5233
Ryan KM, Poelz L, McLoughlin DM., Low Circulating Levels of GR, FKBP5, and SGK1 in Medicated Patients With Depression Are Not Altered by Electroconvulsive Therapy., The journal of ECT, 2019
Ryan KM, McLoughlin DM., Telomere length in depression and association with therapeutic response to electroconvulsive therapy and cognitive side-effects., Psychological medicine, 2019, p1-11
Karen M. Ryan, Declan M. McLoughlin, Peripheral blood GILZ mRNA levels in depression and following electroconvulsive therapy, Psychoneuroendocrinology, 2019
Hartnett Y, Drakeford C, Dunne L, McLoughlin DM, Kennedy N., Physician, heal thyself: a cross-sectional survey of doctors' personal prescribing habits., Journal of medical ethics, 2019
Soda T, McLoughlin DM, Clark SR, Oltedal L, Kessler U, Haavik J, Bousman C, Smith DJ, Bioque M, Clements CC, Loo C, Vila-Rodriguez F, Minelli A, Mickey BJ, Milev R, Docherty AR, Langan Martin J, Achtyes ED, Arolt V, Redlich R, Dannlowski U, Cardoner N, Clare E, Craddock N, Di Florio A, Dmitrzak-Weglarz M, Forty L, Gordon-Smith K, Husain M, Ingram WM, Jones L, Jones I, Juruena M, Kirov G, Landén M, Müller DJ, Nordensköld A, Pålsson E, Paul M, Permoda A, Pliszka B, Rea J, Schubert KO, Sonnen JA, Soria V, Stageman W, Takamiya A, Urretavizacaya M, Watson S, Zavorotny M, Young AH, Vieta E, Rybakowski JK, Gennarelli M, Zandi PP, Sullivan PF, Baune BT., International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)., European archives of psychiatry and clinical neuroscience, 2019
Andrew Harkin, Declan M. McLoughlin, Ketamine and depression: A special kase for kynurenic acid?, Brain, Behavior, and Immunity, 2019
O'Reilly H, Hagerty A, O'Donnell S, Farrell A, Hartnett D, Murphy E, Kehoe E, Agyapong V, McLoughlin DM, Farren C., Alcohol Use Disorder and Comorbid Depression: A Randomized Controlled Trial Investigating the Effectiveness of Supportive Text Messages in Aiding Recovery., Alcohol and alcoholism (Oxford, Oxfordshire), 54, (5), 2019, p551-558
Karen M. Ryan, Ross Dunne, Declan M. McLoughlin, BDNF plasma levels and genotype in depression and the response to electroconvulsive therapy, Brain Stimulation, 2018
Martha Finnegan, Stephanie O'Connor, Declan M. McLoughlin, Involuntary and voluntary electroconvulsive therapy: A case-control study, Brain Stimulation, 2018
Ryan KM, Patterson I, McLoughlin DM., Peroxisome proliferator-activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy., Psychological medicine, 2018, p1-10
Finnegan, M., Galligan, T., Ryan, K., Shanahan, E., Harkin, A., Daly, L., McLoughlin, DM., Ketamine versus midazolam for depression relapse prevention following successful electroconvulsive therapy: a randomized controlled pilot trial., Journal of ECT, 2018
Declan M McLoughlin, I know not `seems", Australian & New Zealand Journal of Psychiatry, 2018, p000486741877290
Finnegan M, Bayazit H, Cronin T, Guler K, Galligan T, Karababa FI, McLoughlin DM, Towards International Standards: East Meets West., The journal of ECT, 2018
Claire L. McGrory, Karen M. Ryan, Erik Kolshus, Martha Finnegan, Declan M. McLoughlin, Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy, European Neuropsychopharmacology, 28, (9), 2018, p1015--1023
Kolshus E, Jelovac A, McLoughlin DM, Bitemporal v. high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomized controlled trials - CORRIGENDUM., Psychological medicine, 2018
A.P. Allen, M. Naughton, J. Dowling, A. Walsh, R. O'Shea, G. Shorten, L. Scott, D.M. McLoughlin, J.F. Cryan, G. Clarke, T.G. Dinan, Kynurenine pathway metabolism and the neurobiology of treatment-resistant depression: Comparison of multiple ketamine infusions and electroconvulsive therapy, Journal of Psychiatric Research, 100, 2018, p24--32
Ryan KM, McLoughlin DM., From molecules to mind: mechanisms of action of electroconvulsive therapy., Acta psychiatrica Scandinavica, 138, (3), 2018, p177-179
Kolshus E, Jelovac A, McLoughlin DM, Bitemporal v. high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomized controlled trials., Psychological medicine, 2017
Ryan KM, Glaviano A, O'Donovan SM, Kolshus E, Dunne R, Kavanagh A, Jelovac A, Noone M, Tucker GM, Dunn MJ, McLoughlin DM, Electroconvulsive therapy modulates plasma pigment epithelium-derived factor in depression: a proteomics study., Translational psychiatry, 2017
Brennan S, McLoughlin DM, O'Connell R, Bogue J, O'Connor S, McHugh C, Glennon M, Anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex enhances emotion recognition in depressed patients and controls., Journal of clinical and experimental neuropsychology, 39, (4), 2017, p384-395
Ito M, Bolati K, Kinjo T, Ichimura K, Furuta A, McLoughlin DM, Suzuki T, Arai H, Electroconvulsive stimulation transiently enhances the permeability of the rat blood-brain barrier and induces astrocytic changes., Brain research bulletin, 2017
Kolshus E, Jelovac A, McLoughlin DM, Letter to the Editor: Electrode placement in electroconvulsive therapy - bilateral is still the 'gold standard' for some patients: a reply., Psychological medicine, 2017
Finnegan M, Ryan K, Shanahan E, Harkin A, Daly L, McLoughlin DM, Ketamine for depression relapse prevention following electroconvulsive therapy: protocol for a randomised pilot trial (the KEEP-WELL trial)., Pilot and Feasibility Studies, 2016
Gururajan A, Naughton ME, Scott KA, O'Connor RM, Moloney G, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG, MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c., Translational Psychiatry, 2016
Agyapong VI, Osei A, Mcloughlin DM, McAuliffe E., Task shifting-perception of stake holders about adequacy of training and supervision for community mental health workers in Ghana., Health policy and planning, 31, (5), 2016, p645-655
Gururajan A, Naughton M, Scott K, Moloney G, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin D, Dinan T, Cryan J, PS193. MicroRNAs as biomarkers for treatment-resistant depression., The international journal of neuropsychopharmacology, 2016
McLoughlin DM, Response to Kellner and Farber: Addressing Crossover of High-Dose Right Unilateral ECT to Bitemporal ECT., The American journal of psychiatry, 2016
Semkovska M, Landau S, Dunne R, Kolshus E, Kavanagh A, Jelovac A, Noone M, Carton M, Lambe S, McHugh C, McLoughlin DM., Bitemporal Versus High-Dose Unilateral Twice-Weekly Electroconvulsive Therapy for Depression (EFFECT-Dep): A Pragmatic, Randomized, Non-Inferiority Trial., The American journal of psychiatry, 173, (4), 2016, p408-417
Jelovac A, O"Connor S, McCarron S, McLoughlin DM., Autobiographical Memory Specificity in Major Depression Treated With Electroconvulsive Therapy., The journal of ECT, 32, (1), 2016, p38-43
Hester L, O'Doherty LJ, Schnittger R, Skelly N, O'Donnell M, Butterly L, Browne R, Frorath C, Morgan C, McLoughlin DM, Fearon P., SEQUenCE: a service user-centred quality of care instrument for mental health services., International journal for quality in health care : journal of the International Society for Quality in Health Care, 27, (4), 2015, p284-290
Allen AP, Naughton M, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG, Clarke G., Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT., Journal of affective disorders, 186, 2015, p306-311
Semkovska M, Lambe S, Lonargáin DÓ, McLoughlin DM., Neurocognitive Remediation Therapy for Depression: A Feasibility Study and Randomized Controlled Pilot Protocol Testing., The Journal of nervous and mental disease, 203, (8), 2015, p609-616
O'Donovan SM, O'Mara S, Dunn MJ, McLoughlin DM , The persisting effects of electroconvulsive stimulation on the hippocampal proteome, Brain Research , 1593, 2014, p106 - 116
Noone M, Semkovska M, Carton M, Dunne R, Horgan JP, O'Kane B, McLoughlin DM , Construction and updating of a public events questionnaire for repeated measures longitudinal studies, Front Psychol, 5:230., 2014
Smith KJ, Mullally S, McLoughlin D, O'Mara SM , Validation of the Face-Name Pairs Task in Major Depression: Impaired recall but not recognition. , Frontiers in Psychology , Feb 12;5:92. , 2014
Kolshus E, Dalton VS, Ryan KM, McLoughlin DM, When less is more - microRNAs and psychiatric disorders., Acta psychiatrica Scandinavica, 129, (4), 2014, p241 - 256
Glaviano A, O'Donovan SM, Ryan KM, O'Mara S, Dunn MJ, McLoughlin DM , Acute phase plasma proteins are altered by electroconvulsive stimulation, J Psychopharmacol , 28, (12), 2014, p1125 - 1134
O'Donovan S*, Dalton VS*, Harkin A, McLoughlin DM; * joint first author, Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression. , International Journal of Neuropsychopharmacology. DOI: 10.1017/S1461145714000500, 17, (9), 2014, p1477 - 1486
Dalton, VS, Kolshus, E, McLoughlin, DM, Epigenetics and depression: return of the repressed, Journal of Affective Disorders , 155, (1), 2014, p1-12
Lambe S, Mogg A, Eranti A, Pluck G, Hastilow S, McLoughlin DM, Trends in use of electroconvulsive therapy in South London from 1949 to 2006, J ECT, 30, (4), 2014, p309 - 314
Agyapong V.I.O., Singh K., Savage M., Thekiso B.T., Finn M, Farren C.K. McLoughlin D.M., Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply. , Irish Journal of Psychological Medicine, 30, (01), 2013, p7 - 12
Agyapong, V.I.O., McLoughlin, D.M., Farren, C.K., Six-months outcomes of a randomised trial of supportive text messaging for depression and comorbid alcohol use disorder, Journal of Affective Disorders, 151, (1), 2013, p100-104
Ryan, K.M., O'Donovan, S.M., McLoughlin, D.M., Electroconvulsive stimulation alters levels of BDNF-associated microRNAs, Neuroscience Letters , 549, 2013, p125-129
Agyapong VI, Milnes J, McLoughlin DM, Farren CK, Perception of patients with alcohol use disorder and comorbid depression about the usefulness of supportive text messages., Technology and health care : official journal of the European Society for Engineering and Medicine, 21, (1), 2013, p31-39
Ryan KM, O'Donovan SM, McLoughlin DM, Electroconvulsive stimulation alters levels of BDNF-associated microRNAs., Neuroscience letters, 549, 2013, p125-9
Semkovska M, McLoughlin DM, Measuring Retrograde Autobiographical Amnesia Following Electroconvulsive Therapy: Historical Perspective and Current Issues., The journal of ECT, 29, (2), 2013, p127-133
Skelly N, Schnittger RI, Butterly L, Frorath C, Morgan C, McLoughlin DM, Fearon P, Quality of care in psychosis and bipolar disorder from the service user perspective., Qualitative health research, 23, (12), 2013, p1672-85
Thekiso, T.B., Heron, E.A., Masood, B., Murphy, M., McLoughlin, D.M., Kennedy, N., Mauling of the "celtic Tiger": Clinical characteristics and outcome of first-episode depression secondary to the economic recession in Ireland, Journal of Affective Disorders, 151, (2), 2013, p455-460
Jelovac, A., Kolshus, E., McLoughlin, D.M., Relapse following successful electroconvulsive therapy for major depression: A meta-analysis, Neuropsychopharmacology, 38, (12), 2013, p2467-2474
Practical administration of ECT in, editor(s)A. Easton , The ECT Handbook., London, Royal College of Psychiatrists, 2013, [Dunne, R., McLoughlin, D.M.]
Sinead O'Donovan, Mark Kennedy, Blaithin Guinan, Shane O'Mara, Declan M. McLoughlin, A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour, Progress in Neuropsychopharmacology & Biological Psychiatry, 37, (1), 2012, p147-52
O'Donovan S, Kennedy M, Guinan B, O'Mara S, McLoughlin DM, A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour., Progress in neuro-psychopharmacology & biological psychiatry, 37, (1), 2012, p147-52
Hao Y, Chai KH, McLoughlin DM, Chan HY, Lau KF, Promoter characterization and genomic organization of the human X11ß gene APBA2., Neuroreport, 23, (3), 2012, p146-51
Frodl T, Carballedo A, Hughes MM, Saleh K, Fagan A, Skokauskas N, McLoughlin DM, Meaney J, O'Keane V, Connor TJ, Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder., Translational psychiatry, 2, 2012, pe88
Electroconvulsive therapy, brain stimulation and neurosurgery for mental illness in, editor(s)P. Wright , Core Psychiatry, London, Elsevier, 2012, [Dunne, R., McLoughlin, D.M.]
Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ, Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation., Brain, behavior, and immunity, 26, (6), 2012, p979-987
Agyapong VI, McLoughlin D, Promoting psychiatry as a career option for Ghanaian medical students through a public-speaking competition., Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, 36, (3), 2012, p229-32
Semkovska M, Noone M, Carton M, McLoughlin DM, Measuring consistency of autobiographical memory recall in depression., Psychiatry research, 197, (1-2), 2012, p41-8
Chai KH, McLoughlin DM, Chan TF, Chan HY, Lau KF, Genomic organization and promoter cloning of the human X11" gene APBA1., DNA and cell biology, 31, (5), 2012, p651-9
Dunne RA, McLoughlin DM, Systematic review and meta-analysis of bifrontal electroconvulsive therapy versus bilateral and unilateral electroconvulsive therapy in depression., The World Journal of Biological Psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 13, (4), 2012, p248-258
Agyapong VI, Ahern S, McLoughlin DM, Farren CK, Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial., Journal of affective disorders, 141, (2-3), 2012, p168-76
Eranti SV, Thirthalli J, Pattan V, Mogg A, Pluck G, Velayudhan L, Chan J, Gangadhar BN, McLoughlin DM, Comparison of electroconvulsive therapy practice between London and Bengaluru., The journal of ECT, 27, (4), 2011, p275-80
Ross A. Dunne, Declan M. McLoughlin, Regional Variation in Electroconvulsive Therapy Use, Irish Medical Journal, 104, (3), 2011, p84 - 87
Dunne R, McLoughlin DM, Regional variation in electroconvulsive therapy use., Irish medical journal, 104, (3), 2011, p84-7
Maria Semkovska, Deborah Keane, Oyemi Babalola, Declan M. McLoughlin, Unilateral brief-pulse electroconvulsive therapy and cognition: Effects of electrode placement, stimulus dosage and time, Journal of Psychiatric Research, 45, (6), 2011, p770-780
Semkovska M, Keane D, Babalola O, McLoughlin DM, Unilateral brief-pulse electroconvulsive therapy and cognition: effects of electrode placement, stimulus dosage and time., Journal of psychiatric research, 45, (6), 2011, p770-80
Manser C, Guillot F, Vagnoni A, Davies J, Lau KF, McLoughlin DM, De Vos KJ, Miller CC, Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo., Oncogene, 2011
Wassif, WS, McLoughlin, DM, Vincent, RP, Conroy, S, Russell, GFM, Taylor, NF, Steroid metabolism and excretion in severe anorexia nervosa: effects of refeeding, AMERICAN JOURNAL OF CLINICAL NUTRITION, 93, 2011
Agyapong V.I.O., Farren C.K. and McLoughlin D, Mobile phone text message interventions in psychiatry- what are the possibilities?, Current Psychiatry Reviews, 7, (1), 2011, p1 - 7
Semkovska M, McLoughlin DM , Cognitive effects of electroconvulsive therapy for depression: a systematic review and meta-analysis., Biological Psychiatry, 2010
Yu HT, Chan WW, Chai KH, Lee CW, Chang RC, Yu MS, McLoughlin DM, Miller CC, Lau KF, Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1., Journal of Cellular Biochemistry, 109, (4), 2010, p782-93
Jacqueline C. Mitchell, Michael S. Perkinton, Darran M. Yates, Kwok-Fai Lau, Boris Rogelj, Christopher C.J. Miller, Declan M. McLoughlin, Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease, Journal of Alzheimer's Disease, 20, (1), 2010, p31-36
Semkovska M, McLoughlin DM, Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis., Biological psychiatry, 68, (6), 2010, p568-77
Tracy DK, O'Daly O, Joyce DW, Michalopoulou PG, Basit BB, Dhillon G, McLoughlin DM, Shergill SS, An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers., Neuropsychologia, 48, (1), 2010, p270-7
Lau KF, Perkinton MS, Rodriguez L, McLoughlin DM, Miller CC, An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter., NeuroReport, 21, (11), 2010, p1-6
Tudor EL, Galtrey CM, Perkinton MS, Lau KF, De Vos KJ, Mitchell JC, Ackerley S, Hortobágyi T, Vámos E, Leigh PN, Klasen C, McLoughlin DM, Shaw CE, Miller CC, Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology., Neuroscience, 167, (3), 2010, p774-785
Eranti, SV, Mogg, AJ, Pluck, GC, Landau, S, McLoughlin, DM, Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study., Journal of Affective Disorders, 113, (1-2), 2009, p165 - 171
Mitchell JC, Ariff BB, Yates DM, Lau KF, Perkinton MS, Rogelj B, Stephenson JD, Miller CC, McLoughlin DM., X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice., Human Molecular Genetics, 18, (23), 2009, p4492-4500
McLoughlin DM, Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of major depression. , Evidence Based Mental Health., 12, (3), 2009, p80-81
Yates, DM, Manser, C, De Vos, KJ, Shaw, CE, McLoughlin, DM, Miller, CC, Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments., European Journal of Cell Biology, 88, (4), 2009, p193 - 202
Kelly, B.D., McLoughlin, D.M., Physician-assisted suicide and psychiatry, Psychiatry, 8, (7), 2009, p276-279
Nicholson TRJ, Pariante C, McLoughlin D, Stendhal syndrome: a case of cultural overload., BMJ Case Reports, 2009
Stevenson A, Yates DM, Manser C, De Vos KJ, Vagnoni A, Leigh PN, McLoughlin DM, Miller CCJ, Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. , Neuroscience Letters, 454, (2), 2009, p161-164
Dunne R, Kavanagh A, McLoughlin DM, Electroconvulsive therapy, capacity and the law in Ireland., Irish Journal of Psychological Medicine, 26, 2009, p3-5
Transcranial magnetic stimulation. in, editor(s)Gelder M, Andrreasen, Lopez-Ibor J, Geddes J , New Oxford Textbook of Psychiatry, Oxford University Press, 2009, [McLoughlin D, Mogg A]
Knapp, M, Romeo, R, Mogg, A, Eranti, S, Pluck, G, Purvis, R, Brown, RG, Howard, R, Philpot, M, Rothwell, J, Edwards, D, McLoughlin, DM, Cost-effectiveness of transcranial magnetic stimulation vs. electroconvulsive therapy for severe depression: a multi-centre randomised controlled trial., Journal of Affective Disorders, 109, (3), 2008, p273 - 285
Hotopf M, Laird B, Singh I, Churchill R, David AS, McLoughlin DM, Richardson G, Szmukler G, Capacity, consent and electroconvulsive therapy: A qualitative and cross-sectional study, Journal of Mental Health, 17, (3), 2008, p315-325
Yates D, McLoughlin DM, The molecular pathology of Alzheimer's disease, Psychiatry, 7, (1), 2008, p1-5
McLoughlin DM, Vagus rules still apply., Psychological Medicine, 38, 2008, p625-627
Manser, C, Stevenson, A, Banner, S, Davies, J, Tudor, EL, Ono, Y, Leigh, PN, McLoughlin, DM, Shaw, CE, Miller, CC, Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport., FEBS Letters, 582, (15), 2008, p2303 - 2308
Lau, KF, Chan, WM, Perkinton, MS, Tudor, EL, Chang, RC, Chan, HY, McLoughlin, DM, Miller, CC, Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription., The Journal of Biological Chemistry, 283, (50), 2008, p34728 - 34737
Mogg, A, Pluck, G, Eranti, SV, Landau, S, Purvis, R, Brown, RG, Curtis, V, Howard, R, Philpot, M, McLoughlin, DM, A randomized controlled trial with 4-month follow-up of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression., Psychological Medicine, 38, (3), 2008, p323 - 333
Dunne R, McLoughlin DM, Physical treatments., Medicine, 36, (9), 2008, p499-500
McLoughlin, DM, Miller, CC, The FE65 proteins and Alzheimer's disease., Journal of Neuroscience Research, 86, (4), 2008, p744 - 754
Mogg, A, Purvis, R, Eranti, S, Contell, F, Taylor, JP, Nicholson, T, Brown, RG, McLoughlin, DM, Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: a randomized controlled pilot study., Schizophrenia Research, 93, (1-3), 2007, p221 - 228
McLoughlin DM , Repetitive Transcranial Magnetic Stimulation Versus Electroconvulsive Therapy: Efficacy of Treatment in Nonpsychotic Patients With Depression , 2007, - 1118-1119.
Eranti S, Mogg A, Pluck G, Landau S, Purvis R, Brown RG, Howard R, Knapp M, Philpot M, Rabe-Hesketh S, Romeo R, Rothwell J, Edwards D, McLoughlin DM, A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression , American Journal of Psychiatry, 164, 2007, p73-81
McLoughlin, DM, Mogg, A, Eranti, S, Pluck, G, Purvis, R, Edwards, D, Landau, S, Brown, R, Rabe-Heskith, S, Howard, R, Philpot, M, Rothwell, J, Romeo, R, Knapp, M, The clinical effectiveness and cost of repetitive transcranial magnetic stimulation versus electroconvulsive therapy in severe depression: a multicentre pragmatic randomised controlled trial and economic analysis., Health Technology Assessment (Winchester, England), 11, (24), 2007, p1 - 54
De Vos, KJ, Chapman, AL, Tennant, ME, Manser, C, Tudor, EL, Lau, KF, Brownlees, J, Ackerley, S, Shaw, PJ, McLoughlin, DM, Shaw, CE, Leigh, PN, Miller, CC, Grierson, AJ, Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content., Human Molecular Genetics, 16, (22), 2007, p2720 - 2728
Rogelj, B, Mitchell, JC, Miller, CC, McLoughlin, DM, The X11/Mint family of adaptor proteins., Brain Research Reviews, 52, (2), 2006, p305 - 315
Miller, CC, McLoughlin, DM, Lau, KF, Tennant, ME, Rogelj, B, The X11 proteins, Abeta production and Alzheimer's disease., Trends in Neurosciences, 29, (5), 2006, p280 - 285
Kelly BD, McLoughlin DM, Physician-assisted suicide and psychiatry, Psychiatry, 5, (8), 2006, p289-291
Tudor, EL, Perkinton, MS, Schmidt, A, Ackerley, S, Brownlees, J, Jacobsen, NJ, Byers, HL, Ward, M, Hall, A, Leigh, PN, Shaw, CE, McLoughlin, DM, Miller, CC, ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth., The Journal of Biological Chemistry, 280, (41), 2005, p34735 - 34740
Mineur YS, McLoughlin D, Crusio WE, Sluyter F, Genetic mouse models of Alzheimer's disease., Neural Plast, 12, (4), 2005, p299-310
Uher, R, Yoganathan, D, Mogg, A, Eranti, SV, Treasure, J, Campbell, IC, McLoughlin, DM, Schmidt, U, Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving., Biological Psychiatry, 58, (10), 2005, p840 - 842
Is ECT given in bipolar disorder and does TMS offer more? in, editor(s)McDonald C, Schulz K, Murray RM, Tohen M , Bipolar Disorder: The Upswing in Research and Treatment., London, Parthenon Publishing, 2005, [Mogg A, Erranti S, Pluck G, McLoughlin DM. ]
Lee J-H, Lau K-F, Perkinton MS, Standen CL, Rogelj B, Falinska A, McLoughlin DM, Miller CCJ, The Neuronal Adaptor Protein X11beta Reduces Amyloid beta-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice*, Journal of Biological Chemistry, 279, 2004, p49099-49104
Perkinton, MS, Standen, CL, Lau, KF, Kesavapany, S, Byers, HL, Ward, M, McLoughlin, DM, Miller, CC, The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling., The Journal of Biological Chemistry, 279, (21), 2004, p22084 - 22091
McLoughlin DM, Review: repetitive transcranial magnetic stimulation is of unknown effectiveness in people with depression., Evidence Based Mental Health, 6, (4), 2003, p118
Lee, JH, Lau, KF, Perkinton, MS, Standen, CL, Shemilt, SJ, Mercken, L, Cooper, JD, McLoughlin, DM, Miller, CC, The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice., The Journal of Biological Chemistry, 278, (47), 2003, p47025 - 47029
Kesavapany, S, Lau, KF, Ackerley, S, Banner, SJ, Shemilt, SJ, Cooper, JD, Leigh, PN, Shaw, CE, McLoughlin, DM, Miller, CC, Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase., The Journal of Neuroscience, 23, (12), 2003, p4975 - 4983
Eranti SV, McLoughlin DM, Electroconvulsive therapy - state of the art, British Journal of Psychiaty, 182, 2003, p8 - 9
Eranti SV, McLoughlin DM. , Changing use of ECT, 2003, - 173
Kelly, B.D., McLoughlin, D.M., Euthanasia, assisted suicide and psychiatry: a Pandora's box, Journal of Psychiatry, 181, (4), 2002, p278-279
Lau, KF, Howlett, DR, Kesavapany, S, Standen, CL, Dingwall, C, McLoughlin, DM, Miller, CC, Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability., Molecular and Cellular Neurosciences, 20, (1), 2002, p13 - 20
Kesavapany, S, Banner, SJ, Lau, KF, Shaw, CE, Miller, CC, Cooper, JD, McLoughlin, DM, Expression of the Fe65 adapter protein in adult and developing mouse brain., Neuroscience, 115, (3), 2002, p951 - 960
Lovestone, S, McLoughlin, DM, Protein aggregates and dementia: is there a common toxicity?, Journal of Neurology, Neurosurgery, and Psychiatry, 72, (2), 2002, p152 - 161
Lyons, D, McLoughlin, DM, Recent advances: Psychiatry., BMJ (Clinical research ed.), 323, (7323), 2001, p1228 - 1231
McLoughlin, DM, Standen, CL, Lau, KF, Ackerley, S, Bartnikas, TP, Gitlin, JD, Miller, CC, The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity., The Journal of Biological Chemistry, 276, (12), 2001, p9303 - 9307
Standen, CL, Brownlees, J, Grierson, AJ, Kesavapany, S, Lau, KF, McLoughlin, DM, Miller, CC, Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3)., Journal of Neurochemistry, 76, (1), 2001, p316 - 320
Kesavapany S, Lau K-F, McLoughlin DM, Brownlees J, Ackerley S, Leigh NP, Shaw CE, Miller CCJ, p35/cdk5 binds and phosphorylates β-catenin and regulates β-catenin/presenilin-1 interaction, European Journal of Neuroscience, 13, (2), 2001, p241-247
Lau K-F, McLoughlin DM, Standen C, Irving NG, Miller CCJ, Fe65 and X11beta co-localise with and compete for binding to the amyloid precursor protein. , Neuroreport, 11, (16), 2000, p3607-3610
Lau K-F, McLoughlin DM, Standen C, Miller CCJ, X11α and X11β Interact with Presenilin-1 via Their PDZ Domains , Molecular Cell Neuroscience, 16, (5), 2000, p555-563
Morton J, McLoughlin DM, Whiting S, Russell GFM, Carnitine levels in patients with skeletal myopathy due to anorexia nervosa before and after refeeding., International Journal of Eating Disorders, 26, 1999, p341-344
McLoughlin DM, Irving NG, Brownlees J, Brion J-P, Leroy K, Miller CCJ, Mint2/X11-like co-localises with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease., European Journal of Neuroscience, 11, (6), 1999, p1988-1994
Physical disorders and psychiatric illness. in, editor(s)Wheatley D, Smith D , Psychopharmacology of Cognitive and Psychiatric Disorders in the Elderly., London, Chapman & Hall, 1998, [Krasucki C, McLoughlin DM.]
McLoughlin DM, Irving NG, Miller CCJ, The Fe65 and X11 families of proteins: proteins that interact with the Alzheimer's disease amyloid precursor protein., Biochemical Society Transactions, 26, 1998, p497-500
Dementia: Basic Neurosciences. in, editor(s)Brocklehurst J, Tallis R, Flint H , Brocklehurst's Textbook of Geriatric Medicine & Gerontology, Edinburgh, Churchill Livingstone, 1998, [Carter J, McLoughlin DM.]
McLoughlin DM, Spargo T, Wassif W, Newham D, Peters TJ, Lantos P, Russell GFM, Structural and functional changes in skeletal muscle in anorexia nervosa., Acta Neuropathologica, 95, (6), 1998, p632-640
Guidato S, McLoughlin DM, Grierson A, Miller CCJ., Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity., Journal of Neurochemistry, 70, (1), 1998, p335-340
Blanco G, Brown SDM, Irving N, Miller CCJ, McLoughlin DM. , Mapping of the human and murine X11-like genes, the murine Fe65 gene and the human Fe65-like gene: genes encoding for phosphotyrosine binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein., Mammalian Genome, 9, (6), 1998, p473-475
Holmes C, McLoughlin D, Powell J, Lovestone S., Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease, 1997, - 274
Substance misuse in the elderly in, Norman IJ, Redfern SJ , Mental Health Care for Elderly People. , London, Churchill Livingstone, 1997, [McLoughlin DM, Farrell M.]
McLoughlin D, Levy R., The differential diagnosis of dementia. , Acta Neurologica Scandinavica, S165, 1996, p92-100
Holmes C, Levy R, McLoughlin DM, Powell JF, Lovestone S. , Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease., Journal of Neurology, Neurosurgery, and Psychiatry , 61, 1996, p580-583
McLoughlin DM, Cooney C, Holmes C, Levy R. , Carer informants for dementia sufferers: carer awareness of cognitive impairment in an elderly-community resident sample., Age and Ageing, 25, (5), 1996, p367-371
McLoughlin D., A Palpable Hit (review of the movie "Trainspotting") , 1996, - 585
McLoughlin DM, Miller CCJ. , The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosisine-binding domain proteins in the yeast two-hybrid system. , FEBS Letters, 397, (2-3), 1996, p197-200
McLoughlin D, Natural Born Killers, 1995, - 499-500
Richards M, McLoughlin D, Levy R. , The relationship between extrapyramidal signs and cognitive function in patients with moderate to severe Alzheimer's disease., International Journal of Geriatric Psychiatry, 10, (5), 1995, p395-399
McLoughlin D, Realism about mental illness (review of the television documentary series "Minders")., 1995, - 1205
McLoughlin D, Carter J., Conference Report: The Fourth International Conference on Alzheimer's Disease and Related Disorders, International Journal of Geriatric Psychiatry, 9, 1994, pp1003-1004
McLoughlin D, Lucey J, Dinan T., Central serotonergic hyperresponsivity in late-onset Alzheimer's disease. , American Journal of Psychiatry, 151, (11), 1994, p1701-1703
McLoughlin D, Lovestone S., Alzheimer's disease: recent advances in molecular pathology and genetics., International Journal of Geriatric Psychiatry, 9, (6), 1994, p431-444
Farren C, McLoughlin D, Clare A. , Procedures for involuntary admission to public and private psychiatric facilities. , Irish Journal of Psychological Medicine, 9, (2), 1992, p96-100
O'Keane V, McLoughlin D, Dinan T. , D-fenfluramine-induced prolactin and cortisol release in major depression: response to treatment., Journal of Affective Disorders, 26, (3), 1992, p143-150.
McLoughlin D, McKeon P., Bipolar disorder and cerebral sarcoidosis., British Journal of Psychiatry, 158, 1991, p410-413
McLoughlin D, Priest R., Halcyon days over for our favourite hypnotic, 1991, - 13
McLoughlin D, Priest R., Life after Halcion: what are the remaining options?, 1991, - 13-15
Non-Peer-Reviewed Publications
Semkovska M, McLoughlin DM , Retrograde autobiographical amnesia following ECT: on the difficulty of finding the baby and clearing murky bathwater, J ECT, 30, (3), 2014, p187 - 188
Dunne RA, McLoughlin DM, Physical treatments, Medicine , 40, 2012, p672 - 673
McLoughlin, DM, Vagus rules still apply., Psychological Medicine, 38, (5), 2008, p625 - 627
McLoughlin, DM, Review: repetitive transcranial magnetic stimulation is of unknown effectiveness in people with depression., Evidence-Based Mental Health, 6, (4), 2003, p118 - 118
Cigeroglu YB, McLoughlin D., Psychotherapy training in Turkey, 1994, - 650-651
Lovestone S, McLoughlin D., Alzheimer's disease: molecular biology and the quest for a treatment. , Care of the Elderly, 6, 1994, p149-152