Professor Marina Annetta Lynch
Fellow Emeritus, Physiology
Biography
Qualifications: BSc (NUI), PhD (TCD)
1981-1983 Pharmacology Department, King's College, London.
1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience
Publications and Further Research Outputs
Peer-Reviewed Publications
Lynch, M.A., A case for seeking sex-specific treatments in Alzheimerâ s disease, Frontiers in Aging Neuroscience, 16, (1346621), 2024
Mela, V. and Gaban, A.S. and Shatz, P.M. and Guillot-Sestier, M.-V. and Lynch, M.A., Acute Stress, Induced by IFNγ + Aβ, and Chronic Stress, Induced by Age, Affect Microglia in a Sex-Specific Manner, Molecular Neurobiology, 60, (6), 2023, p3044-3053
Mela, V. and Gaban, A.S. and Oâ neill, E. and Bechet, S. and Walsh, A. and Lynch, M.A., The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific, Cells, 11, (4), 2022
Paolicelli, R.C. and Sierra, A. and Stevens, B. and Tremblay, M.-E. and Aguzzi, A. and Ajami, B. and Amit, I. and Audinat, E. and Bechmann, I. and Bennett, M. and Bennett, F. and Bessis, A. and Biber, K. and Bilbo, S. and Blurton-Jones, M. and Boddeke, E. and Brites, D. and BrÎne, B. and Brown, G.C. and Butovsky, O. and Carson, M.J. and Castellano, B. and Colonna, M. and Cowley, S.A. and Cunningham, C. and Davalos, D. and De Jager, P.L. and de Strooper, B. and Denes, A. and Eggen, B.J.L. and Eyo, U. and Galea, E. and Garel, S. and Ginhoux, F. and Glass, C.K. and Gokce, O. and Gomez-Nicola, D. and González, B. and Gordon, S. and Graeber, M.B. and Greenhalgh, A.D. and Gressens, P. and Greter, M. and Gutmann, D.H. and Haass, C. and Heneka, M.T. and Heppner, F.L. and Hong, S. and Hume, D.A. and Jung, S. and Kettenmann, H. and Kipnis, J. and Koyama, R. and Lemke, G. and Lynch, M. and Majewska, A. and Malcangio, M. and Malm, T. and Mancuso, R. and Masuda, T. and Matteoli, M. and McColl, B.W. and Miron, V.E. and Molofsky, A.V. and Monje, M. and Mracsko, E. and Nadjar, A. and Neher, J.J. and Neniskyte, U. and Neumann, H. and Noda, M. and Peng, B. and Peri, F. and Perry, V.H. and Popovich, P.G. and Pridans, C. and Priller, J. and Prinz, M. and Ragozzino, D. and Ransohoff, R.M. and Salter, M.W. and Schaefer, A. and Schafer, D.P. and Schwartz, M. and Simons, M. and Smith, C.J. and Streit, W.J. and Tay, T.L. and Tsai, L.-H. and Verkhratsky, A. and von Bernhardi, R. and Wake, H. and Wittamer, V. and Wolf, S.A. and Wu, L.-J. and Wyss-Coray, T., Microglia states and nomenclature: A field at its crossroads, Neuron, 110, (21), 2022, p3458-3483
Lynch, M.A., Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine, Frontiers in Aging Neuroscience, 14, (868448), 2022
Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O'Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA., Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease., Commun Biol, 4, (1), 2021, p711
Lynch, M.A., Can the emerging field of immunometabolism provide insights into neuroinflammation?, Progress in Neurobiology, 184, (101719), 2020
Mela, V. and Mota, B.C. and Milner, M. and McGinley, A. and Mills, K.H.G. and Kelly, Ã .M. and Lynch, M.A., Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells, Brain, Behavior, and Immunity, 87, 2020, p413-428
Finucane O.M, Sugrue J, Rubio-Araiz A, Guillot-Sestier M.-V, Lynch M.A, The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages, Scientific Reports, 9, (1), 2019
McIntosh A, Mela V, Harty C, Minogue AM, Costello DA, Kerskens C, Lynch MA., Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice., Brain Pathology, 2019, p10.1111/bpa.12704.
Wolfe H, Rivas VM, Minogue AM, Miller AM, McGuigan C, Williams L, Lohan D, Lawlor BA, Lynch MA., Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming., Neuroscience Research, 2019, p1-
Wolfe, H. and Minogue, A.M. and Rooney, S. and Lynch, M.A., Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice, Mechanisms of Ageing and Development, 173, 2018, p84-91
Rubio-Araiz, A. and Finucane, O.M. and Keogh, S. and Lynch, M.A., Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid, Journal of Neuroinflammation, 15, (1), 2018, p247-
Holland, R. and McIntosh, A.L. and Finucane, O.M. and Mela, V. and Rubio-Araiz, A. and Timmons, G. and McCarthy, S.A. and Gun'ko, Y.K. and Lynch, M.A., Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice, Brain, Behavior, and Immunity, 2018, p183-196-
Wolfe H, Hannigan C, O'Sulivan M, Carrol, LB, Brennan S, Lawlor, R, Robertson, IH, Lynch, M, A shift to glycolysis accompanies the inflammatory changes in PBMCs from Individuals with an IQ-discrepant memory, Journal of Neuroimmunology, 317, 2018, p24 - 31
Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243
McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12
Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 54, (7), 2017, p5730 - 5739
C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316
Andreasson K.I, Bachstetter A.D, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee D.C, Low D, Lynch M.A, Monsonego A, O'Banion M.K, Pekny M, Puschmann T, Russek-Blum N, Sandusky L.A, Selenica M.-L.B, Takata K, Teeling J, Town T, Van Eldik L.J, Targeting innate immunity for neurodegenerative disorders of the central nervous system, Journal of Neurochemistry, 2016, p653 - 693
Drechsler S, Lynch M.A, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro R.E, Vandenbroucke R.E, Osuchowski M, Potter P.K, With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions, Mechanisms of Ageing and Development, 160, 2016, p54 - 68
McHugh Power, J.E., Carney, S., Hannigan, C., Brennan, S., Wolfe, H., Lynch, M., Kee, F. and Lawlor, B.A., Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort, Journal of Health Psychology, 2016
Costello D.A, Keenan K, McManus R.M, Falvey A, Lynch M.A, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function, Neurobiology of Aging, 43, 2016, p140 - 148
McHugh Power, J.E., Carney, S., Hannigan, C., Brennan, S., Wolfe, H., Lynch, M., Kee, F. and Lawlor, B.A., , Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort, Journal of Health Psychology, 2016
McDonald C.L, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, Reilly M, Lynch M.A, Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease, Brain, Behavior, and Immunity, 58, 2016, p191 - 200
Costello DA, Keenan K, McManus RM, Falvey A, Lynch MA, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function., Neurobiology of aging, 43, 2016, p140-8
Lynch, MA, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair, Current Opinion in Pharmacology, 26, 2015, p67 - 73
Barrett J., Minogue A., Falvey A., Lynch M., Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages, Experimental Cell Research, 335, (2), 2015, p258-268
Barrett J., Costello D., O'Sullivan J., Cowley T., Lynch M., Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli, Journal of Neuroinflammation, 12, (1), 2015, p67
Marina A Lynch, Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β, Brain Research, 2015
Lynch, MA, Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli., Journal of Alzheimers Disease, 44 , (3), 2015, p949-962
Bryson KJ, Lynch MA, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair., Current opinion in pharmacology, 26, 2015, p67-73
Lynch, MA, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR. , Brain Behaviour Immunity, 46, 2015, p70-79
Raasay S. Jones, Aedín M. Minogue, Orla Fitzpatrick, Marina A. Lynch, Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice, Experimental Cell Research, 36, (10), 2015, p2716-2724
Costello D.A, Carney D.G, Lynch M.A, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR, Brain, Behavior, and Immunity, 46, 2015, p70 - 79
Raasay S. Jones and Marina A. Lynch, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 96, (A), 2015, p3-10
Karen Bryson and Marina Lynch, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair, Curr Opin Pharmacol. , 26,, 2015, 67-73.
McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, 10, (4), 2015, p547-560
McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121
Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17
Murphy, N., Grehan, B., Lynch, M.A., Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10, NeuroMolecular Medicine, 16, (1), 2014, p205-215
Distrutti E, O'Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S, Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP., PloS one, 9, (9), 2014, pe106503
Aedín M. Minogue, Raasay S. Jones, Ronan J. Kelly, Claire L. McDonald, Thomas J. Connor and Marina A. Lynch., Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice, Neurobiology of Aging , 2014, p1-30
Denieffe S, Kelly RJ, McDonald C, Lyons A, Lynch MA, Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells., Brain, behavior, and immunity, 34, 2013, p86-97
McGuckin CP, Jurga M, Miller AM, Sarnowska A, Wiedner M, Boyle NT, Lynch MA, Jablonska A, Drela K, Lukomska B, Domanska-Janik K, Kenner L, Moriggl R, Degoul O, Perruisseau-Carrier C, Forraz N, Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction., Archives of biochemistry and biophysics, 534, (1-2), 2013, p88-97
Lynch MA, The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease., Immunology, 141, (3), 2013, p292-301
Cowley TR, González-Reyes RE, Richardson JC, Virley D, Upton N, Lynch MA, The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon., Neurochemical research, 38, (6), 2013, p1190-5
Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51
Jones RS, Minogue AM, Connor TJ, Lynch MA, Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8, (1), 2013, p301-311
Cox FF, Berezin V, Bock E, Lynch MA, The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner., Neuroscience, 235, 2013, p141-148
Downer EJ, Johnston DG, Lynch MA, Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia., Molecular and cellular neurosciences, 56C, 2013, p148-158
Eric J. Downer, Raasay S. Jones, Claire L. McDonald, Eleonora Greco, Sabina Brennan, Thomas J. Connor, Ian H. Robertson, Marina A. Lynch, Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory, Plos One, 8, (5), 2013, ppe63194
Ojo B, Gabbott PL, Rezaie P, Corbett N, Medvedev NI, Cowley TR, Lynch MA, Stewart MG, An NCAM Mimetic, FGL, Alters Hippocampal Cellular Morphometry in Young Adult (4 Month-Old) Rats., Neurochemical research, 38, (6), 2013, p1208-1218
Derek A. Costello, and Marina A. Lynch., Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β, Hippocampus, 23, (8), 2013, p696-707
Kelly RJ, Minogue AM, Lyons A, Jones RS, Browne TC, Costello DA, Denieffe S, O'Sullivan C, Connor TJ, Lynch MA, Glial Activation in AßPP/PS1 Mice is Associated with Infiltration of IFN"-Producing Cells., Journal of Alzheimer's disease : JAD, 37, (1), 2013, p63-75
Gallagher JJ, Minogue AM, Lynch MA, Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aß accumulation and microglial activation., Neuro-degenerative diseases, 11, (1), 2013, p33-41
Bunmi Ojo, Payam Rezaie, Paul L. Gabbott, Heather Davies, Frances Colyer, Thelma R. Cowley, Marina Lynch, Michael G. Stewart, Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL, Brain, Behavior, and Immunity, 26, (5), 2012, p778-88
Blau CW, Cowley TR, O'Sullivan J, Grehan B, Browne TC, Kelly L, Birch A, Murphy N, Kelly ÁM, Kerskens CM, Lynch MA, The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability., Neurobiology of aging, 33, (5), 2012, p1005.e23-35
F. Fionnuala Cox, Donal Carney, Anne-Marie Miller, Marina A. Lynch, CD200 fusion protein decreases microglial activation in the hippocampus of aged rats, Brain, Behavior, and Immunity, 26, (5), 2012, p789-796
Murphy N, Lynch MA, Activation of the P2X" receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1., Journal of neurochemistry, 123, (5), 2012, p761-770
Minogue AM, Barrett JP, Lynch MA, LPS-induced release of IL-6 from glia modulates production of IL-1ß in a JAK2-dependent manner., Journal of neuroinflammation, 9, 2012, p126
Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA, The neuroprotective effect of a specific P2X" receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells., Brain pathology (Zurich, Switzerland), 22, (3), 2012, p295-306
Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation., Journal of neuroinflammation, 9, 2012, p79
Cowley TR, O'Sullivan J, Blau C, Deighan BF, Jones R, Kerskens C, Richardson JC, Virley D, Upton N, Lynch MA, Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP., Neurobiology of aging, 33, (1), 2012, p162-75
Marina A. Lynch, Rodney W. Johnson, The impact of aging on the brain - risk, resilience and repair, Brain, Behavior, and Immunity, 26, (5), 2012, p714-716
Lyons A, Downer EJ, Costello DA, Murphy N, Lynch MA, Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia., Journal of neuroinflammation, 9, 2012, p107
O'Reilly JA, Lynch M, Rosiglitazone improves spatial memory and decreases insoluble Aß(1-42) in APP/PS1 mice., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7, (1), 2012, p140-4
Lyons A, Murphy KJ, Clarke R, Lynch MA, Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain, Journal of Neuroinflammation, 8, (27), 2011
Bunmi Ojo, Payam Rezaie, Paul L. Gabbott, Thelma R. Cowely, Nikolay I. Medvedev, Marina A. Lynch, Michael G. Stewart, A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus, Experimental Neurology, 232, (2), 2011, p318-328
Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA, Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction., Journal of Neurochemistry, 117, (1), 2011, p100-111
Costello DA, Lyons A, Browne T, Denieffe S, Cox FF, Lynch MA, Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation., The Journal of Biological Chemistry, 286, (40), 2011, p34722-34732
Marina A. Lynch and Kingston H.G. Mills, Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases, Brain, Behavior, and Immunity, 26, (1), 2011, p1-10
J. Kevin Murphy, Anne-Marie Miller, R. Thelma, F. Cowley, Fionnuala Cox and Marina A. Lynch, The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation, Neurochemistry International, 58, (2), 2011, p161-168
Murphy KJ, Miller AM, Thelma R, Cowley F, Cox FF, Lynch MA, The age- and amyloid-ß-related increases in Nogo B contribute to microglial activation., Neurochemistry international, 58, (2), 2011, p161-168
Derek A. Costello, Melanie B. Watson, Thelma R. Cowley, Niamh Murphy, Ciarán Murphy Royal, Cecilia Garlanda & Marina A. Lynch, IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice , Journal of Neuroscience, 31, (10), 2011, p3871-3879
Gallagher JJ, Finnegan ME, Grehan B, Dobson J, Collingwood JF, Lynch MA, Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress., Journal of Alzheimer's disease : JAD, 28, (1), 2011, p147-161
Kelly, L. , Grehan, B. , Chiesa, A.D. , O'Mara, S.M. , Downer, E. , Sahyoun, G. , Massey, K.A. , Nicolaou, A. , Lynch, M.A, The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat, Neurobiology of Aging, 32, (12), 2011, p2318.e1-2318.e15
Watson, M.B., Costello, D.A., Carney, D.G., McQuillan, K., Lynch, M.A., SIGIRR modulates the inflammatory response in the brain , Brain, Behavior, and Immunity, 24, (6), 2010, p985-995
Mc Quillan, KL, Lynch MA, and Mills KH., Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607
Downer, E.J., Cowley, T.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E., Lynch, M.A. , A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , Neurobiology of Aging , 31, (1), 2010, p118 - 128
Lynch MA, Age-related neuroinflammatory changes negatively impact on neuronal function., Frontiers in Aging Neuroscience, 2010, p1-6
Murphy, AC, Lalor, SJ, Lynch, MA and Mills, KH, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607
Piazza A and Lynch MA, Neuroinflammatory changes increase the impact of stressors on neuronal function., Biochemical Society Transactions, 37, (1), 2009, p303-307
Schmid AW, Lynch MA, Herron CE., The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo., Hippocampus, 19, (7), 2009, p670-676
Lyons, A, McQuillan, K, Deighan, BF, O'Reilly, JA, Downer, EJ, Murphy, AC, Watson, M, Piazza, A, O'Connell, F, Griffin, R, Mills, KH, Lynch, MA, Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide., Brain, Behavior, and Immunity, 23, (7), 2009, p1020 - 1027
Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995
Martin, DS, Walsh M, Miller AM, Skerrett HE, Byrne P, Mandel A, Bolton AE and Lynch MA, A novel phospholipid-based drug formulation, VP025, modulates age- and LPS-induced microglial activity in the rat, Neuroimmunomodulation, 16, 2009, p400-410
Gallagher, JJ, Tekoriute, R, O'Reilly, JA, Kerskens, C, Gun'ko, YK, Lynch, M, Bimodal magnetic-fluorescent nanostructures for biomedical applications, Journal of Materials Chemistry, 19, 2009, p4081 - 4084
Loane DJ, Deighan BF, Clarke RM, Griffin RJ, Lynch AM, Lynch MA., Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiology of Aging, 30 , (6), 2009, p920 - 931
Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro., Journal of Neurochemistry, 110, (5), 2009, p1547 - 1556
Miller AM, Piazza A, Martin DS, Walsh M, Mandel A, Bolton AE and Lynch MA , The deficit in long-term potentiation induced by chronic administration of amyloid-beta is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025., Experimental Gerontology, 44, (4), 2009, p300-304
Lynch MA., The multifaceted profile of activated microglia., Molecular Neurobiology, 40, (2), 2009, p139-156
Popov VI, Medvedev NI, Kraev IV, Gabbott PL, Davies H, Lynch MA, Cowley T,, A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study, Eur J Neurosci, 27, (2), 2008, p301-314
Clarke RM, Lyons A, O'Connell F, Deighan BF, Barry CE, Anyakoha NG, Nicolaou A, Lynch MA, A pivotal role for IL-4 in atorvastatin-associated, J Biol Chem., 283, (4), 2008, p1808-1817
Corr, S.A., Byrne, S.J., Tekoriute, R., Meledandri, C.J., Brougham, D.F., Lynch, M., Kerskens, C, O'Dwyer, L, Gun'ko, Y.K. , Linear assemblies of magnetic nanoparticles as MRI contrast agents , Journal of the American Chemical Society , 130, (13), 2008, p4214-4215
Lynch, Marina A , The risky business of ageing. , Brain Behav Immun, 22, 2008, p299 - 300
Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969
Moore M, Piazza A, Nolan Y, Lynch MA., Treatment with dexamethasone and vitamin D(3) attenuates neuroinflammatory age-related changes in rat hippocampus., Synapse, 61, (10), 2007, p851-61
Little SJ, Lynch MA, Manku M and Nicolaou A, Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: A lipidomic analysis., Prostaglandins Leukot Essent Fatty Acids, 77, (3-4), 2007, p155-162
Lyons A., Griffin R, Costelloe C, Clarke RM and Lynch MA , IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro, Journal of Neurochemistry, 101, (3), 2007, p771-781
Clarke RM, O'Connell, F. Lyons A and Lynch MA , The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β in rat hippocampus. The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β in rat hippocampus. , Neuropharmacology , 52 , 2007, p136 - 145
Griffin R, Nally R, Nolan Y, McCartney Y, Linden J and Lynch MA , The age-related attenuation in LTP is associated with microglial activation, Journal of Neurochemistry, 99, (44), 2007, p1263 - 1272
Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA., CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., Journal of Neuroscience, 27, (31), 2007, p8309 - 8313
Minogue AM, Lynch AM, Loane DJ, Herron CE, Lynch MA., Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid., Journal of Neurochemistry, 2007
Loane DJ, Deighan, BF, Clarke RM, Lynch AM, Lynch MA, Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiol Aging., 2007
Maher FO, Clarke RM, Kelly A, Nally RE, Lynch MA, Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation , JOURNAL OF NEUROCHEMISTRY , 96, 6, (MAR), 2006, p1560 - 1571
Lynch MA, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O'connell F, Lynch MA, Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus, Neurobiol Aging, (May 19), 2006
Moore ME, Piazza A, McCartney Y, Lynch MA, Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus, Biochemical Society Transactions, 33, (4), 2005, p1628 - 1633
Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA, Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus , Journal of Neurochemistry, 93, (1), 2005, p221 - 231
Lynch MA, Inflammatory changes in regulation of hippocampal synaptic plasticity in the aged hippocampus , JOURNAL OF NEUROCHEMISTRY , 94, Suppl. 2, (Aug), 2005, pp11
Armstrong ME, Lavelle EC, Loscher CE, Lynch MA, Mills KHG, Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines, Journal of Infectious Diseases, 192, (9), 2005, p1628 - 1633
Nolan Y, Maher FO, Clarke RM, Brady MT, Bolton AE, Mills KHG, Lynch MA, Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus., Journal of Biological Chemistry, 280, (10), 2005, p9354 - 9362
Maher FO, Nolan Y, Lynch MA, Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat., Neurobiology of Aging, 26, (5), 2005, p717 - 728
Nolan Y, Campbell VA, Bolton AE, Lynch MA, Evidence of an anti-inflammatory role for Vasogen's immune modulation therapy, Neuroimmunomodulation, 12, (2), 2005, p113 - 116
Maher FO, Martin DS, Lynch MA, Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase., Neurobiology of Aging, 25, (6), 2004, p705 - 806
Gooney, M., Messaoudi, E., Maher, F.O., Bramham, C.R. and Lynch, M.A., BDNF-induced LTP is associated with enhanced release of endogenous BDNF and glutamate and presynaptic activation of CREB: analysis of deficits in aged rats, Neurobiol. Aging, 25, (10), 2004, p1323-1331
Lynch AM, Walsh C, Delaney A, Nolan Y, Campbell VA, Lynch MA , Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?, Journal of Neurochemistry, 88, (3), 2004, p635 - 646
Dhanrajan TM, Lynch MA, Kelly Á, Popov VI, Rusakov DA , Stewart MG., Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high frequency stimulation alone, Hippocampus, 14, (2), 2004, p255 - 264
Lonergan PE, Martin DSD, Horrobin DF, Lynch MA, Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus, Journal of Neurochemistry, 91, (1), 2004, p20 - 29
Dietrich WD, Pearse DD, Lo TP, Cho KS, Lynch MA, Gorg MS, Marcillo AE, Sanchez AR, Bunge MB, Experimental graded cervical contusion in rats using spinal cord displacement: Pathology and behavioral recovery, JOURNAL OF NEUROTRAUMA , 21, (9), 2004, p1346
Nolan, Y., Martin, D.S.D., Campbell, V.A., and Lynch, M.A., Evidence of a protective effect of phosphatidylserine on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus, J. Neuroimmunol., 151, (Issues 1-2,), 2004, p12-23
Kavanagh, T., Lonergan, P.E. and Lynch, M.A., Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation, Prostaglandins Leukot. Essent. Fatty Acids, 70, 2004, p391 - 397
Lonergan PE, Martin DS, Horrobin DF, Lynch MA, Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus, Journal of Neurochemistry, 91, (1), 2004, p20 - 29
Lynch, M.A., Long-Term Potentiation and memory, Physiol. Rev., 84, 2004, p87 - 136
Minogue, A.M., Schmid, A.W., Fogarty, M.F., Moore, A.C., Campbell, V.A. and Herron, C.E., Activation of the JNK signalling cascade mediates the effect of A beta on LTP and cell death in hippocampus: a role for IL-1 beta, J. Biol. Chem., 278, (30), 2003, p27971 - 27980
Armstrong, M.E., Loscher, C.E., Lynch, M.A. and Mills, K.H.G., IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, (1-2), 2003, p25 - 33
Loscher, C.E., Mills, K.H., Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, J. Neuroimmunol., 137, 2003, p117 - 124
Kelly Á, Vereker E, Brady M. Barry C, Loscher C, Mills KHG, Lynch MA., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462
Lynch, A.M., Moore, M., Craig, S. Lonergan, P.E., Martin, D.S., Lynch, M.A., Analysis of IL-1beta -induced cell signalling activation in rat hippocampus following exposure to gamma irradiation: protective effect of eicosapentaenoic acid, J. Biol. Chem., 278, (51), 2003, p51075 - 51084
Maher, F.O. and Lynch, M.A., Age-related downregulation in neurotrophin-induced signaling and upregulation of interleukin-1 beta-induced signaling combine to decrease synaptic function in rat cortex, Neurobiol. Aging, 2003, p794 - 804
Nolan, Y., Vereker, E., Lynch, A.M., and Lynch, M.A., Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygene species and activation of p38 in rat cortex and hippocampus, Exp. Neurol., 184, (2), 2003, p794 - 804
Loscher, C.E., Mills, K.H.G. and Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type iota receptor, J. Neuroimmunol., 137, (1-2), 2003, p117 - 124
Davies HA, Kelly Á, Dhanrajan TM, Lynch MA, Rodriguez JJ, Stewart MG., Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats, Brain Res., 986, ((1-2):), 2003, p191 - 195
Armstrong, M.E., Loscher, C.E., Lynch, M.A., Mills, K.H., IL-beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, 2003, p25 - 33
Martina Gooney, M. A. Lynch , LONG-TERM POTENTIATION IN AGED RATS IS RESTORED WHEN THE AGE-RELATED DECREASE IN POLYUNSATURATED FATTY ACID CONCENTRATION IS REVERSED, PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 67, (5), 2002, p121 - 130
M. Casey, C. Maguire, Á. Kelly, M.A. Gooney, M.A. Lynch, ANALYSIS OF THE PRESYNAPTIC SIGNALING MECHANISMS UNDERLYING THE INHIBITION OF LTP IN RAT DENTATE GYRUS BY THE TYROSINE KINASE INHIBITOR, GENISTEIN, HIPPOCAMPUS, 12, (3), 2002, p377 - 385
Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch, Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's immune modulation therapy, Neuroimmunomodulation, 10, (1), 2002, p40 - 46
Lynch AM, Lynch MA, The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation., European Journal of Neuroscience, 15, (11), 2002, p1779 - 1788
Gooney M, Shaw K, Kelly Á, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA., Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: evidence for a role for brain-derived neurotrophic factor., Behavioural Neuroscience, 116, (3), 2002, p455 - 463
MURPHY, KJ, NEUROPLASTIC EVENTS REQUIRED-FOR LTP AND AVOIDANCE LEARNING ARE IMPAIRED BY OPIATE ADDICTION, unknown, 2001, 134, ISI Web of Science, 2002, ppU80 - U80
LYNCH, MA , LIPOIC ACID CONFERS PROTECTION AGAINST OXIDATIVE INJURY IN NON-NEURONAL AND NEURONAL TISSUE, NUTRITIONAL NEUROSCIENCE, 4, 2002
HAUSS-WEGRZYNIAK, B, CHRONIC BRAIN INFLAMMATION RESULTS IN CELL LOSS IN THE ENTORHINAL CORTEX AND IMPAIRED LTP IN PERFORANT PATH-GRANULE CELL SYNAPSES, EXPERIMENTAL NEUROLOGY, 176, 2002, p336 - 341
Darren S. D. Martin, Peter E. Lonergan, Barry Boland, Marie P. Fogarty, Marcella Brady, David F. Horrobin, Veronica A. Campbell, and Marina A. Lynch, Apoptotic changes in the aged brain are triggered by interleukin-1 beta-induced activation of P38 and reversed by treatment with eicosapentaenoic acid, Journal of Biological Chemistry, 277, (37), 2002, p34239 - 34246
LYNCH, MA, INTERLEUKIN-1 BETA EXERTS A MYRIAD OF EFFECTS IN THE BRAIN AND IN PARTICULAR IN THE HIPPOCAMPUS: ANALYSIS OF SOME OF THESE ACTIONS, VITAMINS AND HORMONES-ADVANCES IN RESEARCH AND APPLICATIONS, 64, 2002
Lynch, M.A., IL-1beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions, Vitamins and Hormones, 64, 2002, p185 - 219
Peter E. Lonergan, Darren S. D. Martin, David F. Horrobin, and Marina A. Lynch, NEUROPROTECTIVE EFFECT OF EICOSAPENTAENOIC ACID IN HIPPOCAMPUS OF RATS EXPOSED TO GAMMA-IRRADIATION, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, (23), 2002, p20804 - 20811
Sheila Donnelly, Christine E. Loscher, Marina A. Lynch, and Kingston H. G. Mills, Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination, Infection and Immunity, 69, (7), 2001, p4217 - 4223
LYNCH, MA, THE ROLE OF STRESS-ACTIVATED PROTEIN KINASES IN THE INHIBITION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT HIPPOCAMPUS INDUCED BY IL-1, unknown, 2001, 77, ISI Web of Science, 2001, pp18 - 18
Kelly Á, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA. , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572
Vereker, Emily and O'Donnell, Eamonn and Lynch, Ailenn and Nolan, Yvonne and Lynch, Marina A., Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus, European Journal of Neuroscience, 14, (11), 2001, p1809 - 1819
Martina Gooney, M. A. Lynch, LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT HIPPOCAMPUS IS ACCOMPANIED BY BRAIN-DERIVED NEUROTROPHIC FACTOR-INDUCED ACTIVATION OF TRKB, JOURNAL OF NEUROCHEMISTRY, 77, (5), 2001, p1198 - 1207
Lynch, M.A., Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue, Nut. Neurosci, 4, 2001, p419 - 438
Kelly Á, Mullany PM, Lynch MA., Protein synthesis in entorhinal cortex and long-term potentiation in dentate gyrus., Hippocampus, 10, (49), 2000, p431 - 437
CAMPBELL, V, INTRAPERITONEAL ADMINISTRATION OF LIPOPOLYSACCHARIDE INDUCES APOPTOSIS IN RAT ENTORHINAL CORTEX, unknown, 2000, 523, ISI Web of Science, 2000, pp189P - 189P
SHAW, K, STRESS: HOW IT AFFECTS SPATIAL LEARNING AND BDNF EXPRESSION, unknown, 2000, 12, ISI Web of Science, 2000, pp330 - 330
E. Vereker, E. O'Donnell, and M. A. Lynch, The Inhibitory Effect of Interleukin-1b on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases, JOURNAL OF NEUROSCIENCE, 20, (18), 2000, p6811 - 6819
Christine E. Loscher, Sheila Donnelly, Marina A. Lynch Kingston H. G. Mills, Induction of inflammatory cytokines in the brain following respiratory infection with bordetella pertussis, Journal of Neuroimmunology, 102, (2), 2000, p172 - 181
MURPHY, KJ, OPIATE ADDICTION IMPAIRS NEUROPLASTIC EVENTS ASSOCIATED WITH MEMORY FORMATION, unknown, 2000, 12, ISI Web of Science, 2000, pp206 - 206
OMARA, SM, THE EFFECTS OF THE ENDOTOXIN LIPOPOLYSACCHARIDE ON SYNAPTIC TRANSMISSION AND PLASTICITY IN THE CA1-SUBICULUM PATHWAY IN VIVO, unknown, 2000, 12, ISI Web of Science, 2000, pp250 - 250
Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, Marina A. Lynch, INTERLEUKIN-1 BETA-DEPENDENT CHANGES IN THE HIPPOCAMPUS FOLLOWING PARENTERAL IMMUNIZATION WITH A WHOLE CELL PERTUSSIS VACCINE, JOURNAL OF NEUROIMMUNOLOGY, 111, 2000, p68 - 76
Campbell, V. and Lynch, M.A , The role of ceramide in the interleukin-1ß-mediated modulation of [Ca2+]i in rat cortical synaptosomes., Cytokine, 12, (5), 2000, p487 - 490
Vereker E, Campbell V, Roche E, McEntee E, Lynch MA., Lipoplysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1, Journal of Biological Chemistry, 275, (34), 2000, p26252 - 26258
VEREKER, E, LIPOPOLYSACCHARIDE INHIBITS LONG-TERM POTENTIATION AND GLUTAMATE RELEASE IN RAT DENTATE GYRUS, unknown, 2000, 523, ISI Web of Science, 2000, pp188P - 189P
Kelly Á, Maguire C, Lynch MA., Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus, Neuroscience, 95, (2), 2000, p359 - 365
CAMPBELL, V, INTRACEREBROVENTRICULAR ADMINISTRATION OF A CASPASE-1 INHIBITOR BLOCKS THE MODULATORY EFFECTS OF LIPOPOLYSACCHARIDE ON LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS, unknown, 2000, 526, ISI Web of Science, 2000, pp59P - 59P
Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, and Marina A. Lynch, Interleukin-1â-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine , Journal of Neuroimmunology, 111, (1-2), 2000, p68 - 76
Eamonn O'Donnell, Emily Vereker, M. A. Lynch, Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms , EUROPEAN JOURNAL OF NEUROSCIENCE, 12, (1), 2000, p345 - 352
Kelly Á, Lynch MA., Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin, Neuropharmacology, 39, (49), 2000, p643 - 651
Veronica Campbell and Marina A. Lynch , The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1beta in rat cortical synaptosomes, Cytokine, 12, (5), 2000, p487 - 490
MARTIN, DSD, Lynch, MA, A DIET ENRICHED IN ALPHA-LIPOIC ACID REVERSES THE AGE-RELATED COMPROMISE IN ANTIOXIDANT DEFENCES IN RAT CORTICAL TISSUE, NUTRITIONAL NEUROSCIENCE, 3, 2000, p193 - 206
LYNCH, MA, WHAT IS THE BIOLOGICAL SIGNIFICANCE OF AN AGE-RELATED INCREASE IN IL-1 BETA IN HIPPOCAMPUS?, MOLECULAR PSYCHIATRY, 4, 1999, 15 - 18
Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina, GLYCEROL-INDUCED SEIZURE: INVOLVEMENT OF IL-1 BETA AND GLUTAMATE, NEUROREPORT, 10, (9), 1999, p1821 - 1825
McGahon BM, Martin DS, Horrobin DF, Lynch MA., Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids., NEUROSCIENCE, 94, (1), 1999, p305 - 314
C.A. Murray, M.P. Clements & M.A. Lynch, Interleukin-1 Induces Lipid Peroxidation and Membrane Changes in Rat Hippocampus: An Age-Related Study, Gerontology, 45, 1999, p136 - 142
Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina , Glycerol-induced seizure: Involvement of IL-1[beta] and glutamate, NEUROREPORT, 10, (9), 1999, p1821 - 1825
Elizabeth Whittaker, Emily Vereker and M. A. Lynch, Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus , Brain Research , 827, 1999, p229 - 233
B. M. McGahon, C. A. Murray, D. F. Horrobin and M. A. Lynch, Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, NEUROBIOLOGY OF AGING, 20, (6), 1999, p643 - 653
McGahon B, Maguire C, Kelly Á, Lynch MA., Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes., NEUROSCIENCE, 90, (4), 1999, p1167 - 1175
Maguire C, Casey M, Kelly Á, Mullany PM. Lynch MA. , Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus, Hippocampus, 9, (5), 1999, p519 - 526
Bernadette M. McGahon, Donen S. D. Martin, David F. Horrobin and Marina A. Lynch, Age-related changes in LTP and antioxidant defenses are reversed by an á-lipoic acid-enriched diet, NEUROBIOLOGY OF AGING, 20, (6), 1999, p655 - 664
McGahon, B.M., Murray, C.A., Horrobin, D.F. and Lynch, M.A., Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, Neurobiol. Aging, 20, (6), 1999, p643 - 653
V. A. Campbell, R. Segurado and M. A. Lynch, Regulation of intracellular Ca2+ concentration by interleukin-1â in rat cortical synaptosomes: an age-related study , Neurobiology of Aging, 19, (6), 1998, p575 - 579
MCGAHON, B, LYNCH, MA, ANALYSIS OF THE INTERACTION BETWEEN ARACHIDONIC ACID AND METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION REVEALS THAT PHOSPHOLIPASE C ACTS AS A COINCIDENCE DETECTOR IN THE EXPRESSION OF LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS, HIPPOCAMPUS, 8, 1998, p48 - 56
LYNCH, MA, AGE-RELATED IMPAIRMENT IN LONG-TERM POTENTIATION IN HIPPOCAMPUS: A ROLE FOR THE CYTOKINE, INTERLEUKIN-1 BETA?, PROGRESS IN NEUROBIOLOGY, 56, 1998
LYNCH, MA, ANALYSIS OF THE MECHANISMS UNDERLYING THE AGE-RELATED IMPAIRMENT IN LONG-TERM POTENTIATION IN THE RAT, REVIEWS IN THE NEUROSCIENCES, 9, 1998, p169 - 201
Campbell, V. and Lynch, M.A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1ß in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, Neuroreport , 9, (9), 1998, p1923 - 1927
Murray, C A , Lynch, M A, Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1 Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation, JOURNAL OF NEUROSCIENCE, 18, (8), 1998, p2974 - 2981
Kelly Á, Lynch MA., LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD, Neuroreport, 9, (18), 1998, p4087 - 4091
Loscher CE, Donnelly S, McBennett S, Lynch MA, Mills KH., Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine., Annals of the New York Academy of Sciences, 856, 1998, p274 - 277
MCGAHON, B, MURRAY, CA, CLEMENTS, MP, LYNCH, MA, ANALYSIS OF THE EFFECT OF MEMBRANE ARACHIDONIC ACID CONCENTRATION ON MODULATION OF GLUTAMATE RELEASE BY INTERLEUKIN-1: AN AGE-RELATED STUDY, EXPERIMENTAL GERONTOLOGY, 33, 1998, p343 - 354
CAMPBELL, VA, BIPHASIC MODULATION OF [CA2+](1) BY INTERLEUKIN-1 BETA IN RAT CORTICAL SYNAPTOSOMES, unknown, 1998, 509P, ISI Web of Science, 1998, pp55P - 55P
[DEPT. PHYSIOLOGY PUBLICATION] Campbell V.A. and Segurado R. and Lynch M. A., Regulation of intracellular Ca2+ concentration by interleukin-1beta in rat cortical synaptosomes: an age-related study, Neurobiology of Aging, 19, (6), 1998, p575 - 579
Campbell, Veronica; Lynch, Marina A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1[beta] in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, NEUROREPORT, 9, (9), 1998, p1923 - 1927
Ciara A. Murray and Marina A. Lynch , DIETARY SUPPLEMENTATION WITH VITAMIN E REVERSES THE AGE-RELATED DEFICIT IN LONG TERM POTENTIATION IN DENTATE GYRUS, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, (20), 1998, p12161 - 12168
Mullany PM, Lynch MA., Evidence for a role for synaptophysin in expression of long-term potentiation in rat dentate gyrus., NEUROREPORT, 9, (11), 1998, p2489 - 2494
DHANRAJAN, TM, PLASTICITY OF DENDRITIC SPINES IN HIPPOCAMPUS OF YOUNG AND AGED RATS 45 MIN AFTER LTP INDUCTION., unknown, 1998, 10, ISI Web of Science, 1998, pp391 - 391
E. O'Donnell and M. A. Lynch, DIETARY ANTIOXIDANT SUPPLEMENTATION REVERSES AGE-RELATED NEURONAL CHANGES, NEUROBIOLOGY OF AGING, 19, (5), 1998, p461 - 467
Kelly Á, Conroy S, Lynch MA., Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus., Neuropharmacology, 37, (4-5), 1998, p561 - 570
Murray, C. and Lynch, M.A., Analysis of the mechanism by which dietary supplementation with vitamin E and vitamin C restores ability of aged animals to sustain long-term potentiation in dentate gyrus, J. Biol. Chem., 273, (20), 1998, p12161 - 12168
KELLY, A, EVIDENCE INDICATING A ROLE FOR NERVE GROWTH FACTOR IN LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT, unknown, 1997, 501P, ISI Web of Science, 1997, ppP89 - P89
McGahon B, Holscher C, McGlinchey L, Rowan MJ, Lynch MA., Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus., Learning and Memory, 3, (4), 1997, p296 - 304
MCGAHON, B, EVIDENCE THAT LONG-TERM POTENTIATION IN RAT DENTATE GYRUS UTILIZES PHOSPHOLIPASE C AS A COINCIDENCE DETECTOR: INVESTIGATION OF THE INTERACTION BETWEEN ARACHIDONIC ACID AND THE METABOTROPIC GLUTAMATE RECEPTOR AGONIST, 1-AMINO-CYCLOPENTANE-1,3-DICARBOXYLATE, unknown, 1997, 501P, ISI Web of Science, 1997, ppP88 - P88
MULLANY, P, INDUCTION OF LONG-TERM POTENTIATION IN VIVO IN RAT DENTATE GYRUS IS ACCOMPANIED BY AN INCREASE IN PHOSPHORYLATION OF RECEPTOR TYROSINE KINASE, unknown, 1997, 501P, ISI Web of Science, 1997, ppP87 - P88
Murray CA, McGahon B, McBennett S, Lynch MA., Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats., NEUROBIOLOGY OF AGING, 18, (3), 1997, p343 - 348
MURRAY, CA, IMPAIRED ABILITY OF AGED RATS TO SUSTAIN LONG-TERM POTENTIATION MAY RESULT FROM INCREASED HIPPOCAMPAL EXPRESSION OF INTERLEUKIN-1 BETA, unknown, 1997, 501P, ISI Web of Science, 1997, ppP87 - P87
McGahon B, Clements MP, Lynch MA., The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed., NEUROSCIENCE, 81, (1), 1997, p9 - 16
LYNCH, MA, AGE-RELATED CHANGES IN SYNAPTIC PLASTICITY IN RAT HIPPOCAMPUS, unknown, 1997, 501P, ISI Web of Science, 1997, ppS5 - S6
P. Mullany and M. A. Lynch , CHANGES IN PROTEIN SYNTHESIS AND SYNTHESIS OF THE SYNAPTIC VESICLE PROTEIN, SYNAPTOPHYSIN, IN ENTORHINAL CORTEX FOLLOWING INDUCTION OF LONG-TERM POTENTIATION IN DENTATE GYRUS: AN AGE-RELATED STUDY IN THE RAT, NEUROPHARMACOLOGY, 36, (7), 1997, p973 - 980
McGahon B, Lynch MA., THE SYNERGISM BETWEEN ACPD AND ARACHIDONIC ACID ON GLUTAMATE RELEASE IN HIPPOCAMPUS IS AGE-DEPENDENT, EUROPEAN JOURNAL OF PHARMACOLOGY, 309, (3), 1996, p323 - 326
Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ., Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro., Neuroscience Letters, 203, (1), 1996, p17 - 20
Patricia Mullany, Shane Connolly and Marina A. Lynch, Ageing is associated with changes in glutamate release, protein tyrosine kinase and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus , EUROPEAN JOURNAL OF PHARMACOLOGY, 309, (3), 1996, p311 - 315
B. McGahon and M. A. Lynch, The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus , NEUROSCIENCE, 72, (3), 1996, p847 - 855
Cunningham, A.J., Murray, C.A., O'Neill, L.A.J., Lynch, M.A. and O'Connor, J.J., Interleukin-1â (IL-1â) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro, Neurosci. Letts., 203, (1), 1996, p17 - 20
MCGAHON, B, THE SYNERGISM BETWEEN ARACHIDONIC-ACID AND ACPD ON GLUTAMATE RELEASE IN DENTATE GYRUS IS OCCLUDED BY INDUCTION OF LONG-TERM POTENTIATION, unknown, 1995, 489P, ISI Web of Science, 1995, ppP6 - P7
Lynch, M.A., Voss, K.L., Rodriguez, J. and Bliss, T.V.P., Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus, Neuroscience, 60, (1), 1994, p1 - 5
Lynch, M.A., Jaques-Berg, W., Lawson, P.R., Voss, K.L. and Bliss, T.V.P., The effect of arachidonic acid on uptake in cortical and hippocampal preparations, Neurosci. Res. Comm., 14, 1994, p53 - 61
Lynch MA, Voss KL., Membrane Arachidonic Acid Concentration Correlates with Age and Induction of Long-term Potentiation in the Dentate Gyrus in the Rat, EUROPEAN JOURNAL OF NEUROSCIENCE, 6, (6), 1994, p1008 - 1014
Lynch MA, Voss KL, Gower AJ., Impaired spatial memory in aged rats is associated with alterations in inositol phospholipid metabolism., NEUROREPORT, 5, (12), 1994, p1493 - 1497
McGahon B, Lynch MA., A STUDY OF THE SYNERGISM BETWEEN METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION AND ARACHIDONIC-ACID IN THE RAT HIPPOCAMPUS, NEUROREPORT, 5, (17), 1994, p2353 - 2357
Williams, J.H., Errington, M.L., Li, Y-G., Lynch, M.A. and Bliss, T.V.P., The search for retrograde messangers in long-term potentiation, Seminars in the neurosciences, 5, 1993, p149 - 158
Clements, M.P., Bliss, T.V.P. and Lynch, M.A., Increase in arachidonic acid concentration in a postsynaptic density fraction following the induction of long-term potentiation in the dentate gyrus, Neuroscience, 45, (2), 1991, p379 - 389
Lynch, M.A., Clements, M.P., Voss, K.L., Bramham, C.R. and Bliss, T.V.P., Is arachidonic acid a retrograde messanger inlong-term potentiation?, Biochem. Soc. Trans., 19, 1991, p391 - 386
Jeffreys, J.G.R., Mitchell, P., O'Hara, L., Tiley, C., Hardy, J., Jordan, S.J., Lynch, M.A. and Wandsworth, J., Ex vivo release of GABA from tetanus toxin induced chronic epileptic foci decreased during active seizure phase, Neurochem. Int., Int., (18), 1991, p373 - 379
Lynch, M.A. and Voss, K.L., Presynaptic changes in long-term potentiation: elevated synaptosomal calcium concentration and basal phosphoinositide turnover in dentate gyrus, J. Neurochem., 56, (1), 1991, p113 - 118
Lynch, M.A. and Voss, K.L., Arachidonic acid increases inositol phospholipid metabolims and glutamate release in synaptosomes prepared from hippocampal tissue, J. Neurochem., 55, (1), 1990, p215 - 221
Lynch, M.A., Errington, M.L., Celements, M.P., Bliss, T.V.P., Redini Del Negro, C. and Laroche, S., Increases in glutamate and phosphoinositide metabolism associated with long-term potentiation and classical conditioning, Progr. Brain Res., 83, 1990, p251 - 256
Bliss, T.V., Errington, M.L., Lynch, M.A., Long-term potentiation in the dentate gyrus in vivo is associated with a sustained increase in extracellular glutamate, Adv. Exp. Med. Biol., 268, 1990, p269 - 278
Laroche, R., Redini-Del Negro, C., Clements, M.P., and Lynch, M.A., Long-term activation of phosphoinositide turnover associated with increased release of amino acides in the dentate gyrus and the hippocampus following classical conditioning in the rat., European J. Neurosci., 2, (6), 1990, p534 - 543
Clements, M.P., Errington, M.L., Bliss, T.V.P. and Lynch, M.A., Time-related changes in basal phosphoinositide turnover after induction of long-term potentiation in the dentate gyrus are blocked by commissural stimulation, Eur. J. Neurosci., 2, (4), 1990, p383 - 387
Bliss, T.V.P., Clements, M.P., Errington, M.L., Lynch, M.A. and Williams, J.H., Presynaptic changes associated with long-term potentiation in the dentate gyrus, Semin. Neurosci., 2, 1990
Williams, J.H., Errington, M.L., Lynch, M.A. and Bliss, T.V.P., Arachidonic acid induces a long-term, activity-dependent enhancement of synaptic transmission in the hippocampus, Nature, 341, (6244), 1989, p739 - 742
Lynch, M.A., Mechanisms underlying induction and maintenance of long-term potentiation in the hippocampus, Bioessays, 10, (2-3), 1989, p85 - 90
Lynch, M.A.., Errington, M.L. and Bliss, T.V.P., The increase in [3H]glutamate release associated with long-term potentiation in the dentate gyrus is blocked by commissural stimulation, Neuroscience Letters, 103, (3), 1989, p191 - 197
Lynch, M.A., Errington, M.L. and Bliss, T.V.P., Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat., Neuroscience, 30, (3), 1989, p693 - 701
Lynch, M.A., Clements, M.P., Errington, M.L. and Bliss, T.V.P., Increased hydrolysis of phosphatidylinositol-4,5-bisphosphate in long-term potentiation , Neurosci. Letts., 84, (3), 1988, p291 - 296
Clements, M.P., Lynch, M.A. and Bliss, T.V.P., The increase in phosphoinositide turnover associated with long-term potentiation may be mediated through a GTP binding protein, Neuroscience Research Communnications, 3, 1988, p11 - 19
Errington, M.L., Lynch, M.A., and Bliss, T.V.P., Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)amino-phosphonovalerate, Neuroscience, 20, (1), 1987, p279 - 284
Bliss, T.V.P., Errington, M.L., Laroche, S. and Lynch, M.A., Increase in K+-stimulated, Ca2+-dependent release of [3H]glutamate from rat dentate gyrus three days after induction of long-term potentiation, Neurosci. Letts., 83, (1-2), 1987, p107 - 112
Laroche, S., Errington, M.L., Lynch, M.A., and Bliss, T.V.P., Increase in (3)H glutamate release from slices of dentate gyrus and hippocampus following classical conditioning in the rat, Behavioural Brain Res., 25, (1), 1987, p23 - 29
Spencer, P., Lynch, M. and Bliss, T.V.P., In vitro release of (14)C glutamate from dentate gyrus in modulated by GABA, J. Pharm. Pharmacol., 38, (5), 1986, p393 - 395
Lynch, M. and Bliss, T.V.P., On the mechanism of enhanced release on (14)C glutamate in hippocampal long-term potentiation, Brian Res., 369, (1-2), 1986, p405-408
Lynch, M. and Bliss, T.V.P., Noradrenaline modulates release of (14)C glutamate from dentate but not from CAI/CA3 slices of rat hippocampus, Neuropharmacology, 25, (5), 1986, p493 - 498
Bliss, T.V.P., Douglas, R.M., Errington, M.L. and Lynch, M., Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats, J. Physiol., 377, 1986, p391 - 408
Lynch, M.A.and Bliss, T.V.P., Long-term potentiation of synaptic transmission in CA3: effect of calmodulin and OAG on release of (3)H glutamate, Neurosci. Letts., 65, (2), 1986, p171 - 176
Lynch, M., Archer, E.R.and Littleton, J.M., Increased sensitivity of transmitter release to calcium in ethanol tolerance, Biochem. Pharmacol., 35, (7), 1986, p1207 - 1209
Lynch, M., Errington, M.L. and Bliss, T.V.P., Long-term potentiation of synaptic transmission in dentate gyrus increased of (14)C glutamate without an increase in receptor binding, Neurosci. Letts., 65, (1), 1986, p123 - 129
LYNCH, MA, LOW-DOSES OF T3 INDUCE A RAPID METABOLIC RESPONSE IN YOUNG LAMBS, HORMONE AND METABOLIC RESEARCH, 17, (2), 1985, p63 - 66
Feasey, K.J., Lynch, M.A., and Bliss, T.V.P., Long-term potentiation is associated with an increase in calcium-dependent, potassium-stimulated release of (14)C glutamate from hippocampla slices: an ex vivo study in the rat, Brain Res., 364, 1985, p39 - 44
Lynch, M.A. and Littleton, J.M., Enhanced (3)H noradrenaline release in synaptosomes from ethanol-tolerant animals: the role of nerve terminal Ca(2+), Alcohol and Alcoholism, 20, 1985, p5 - 11
LYNCH, MA, ADMINISTRATION OF LOW-DOSES OF TSH RESULT IN A RAPID INCREASE IN THE METABOLIC-RATE OF YOUNG LAMBS, HORMONE AND METABOLIC RESEARCH, 17, (3), 1985, p136 - 140
M. A. Lynch, J. D. Bruton, J. F. Andrews and R. E. Moore , THE RAPID METABOLIC RESPONSE OF YOUNG LAMBS TO LOW-DOSES OF T3 - INTERACTION WITH RT3, JOURNAL OF THERMAL BIOLOGY, 10, (2), 1985, p71 - 77
Lynch, M., Pagonis, C., Samuel, D. and Littleton, J.M., Alterations in Ca(2+) - dependent and Ca(2+) independent release of catecholamines in preparations of rat brain produced by ethanol treatment in vivo, Alcohol, 2, (1), 1985, p139 - 144
Lynch, M., Littleton, J.M., McKernan, R.M., Durcan, M.J., McMillan, J. and Campbell, I.C., Alpha-adrenoceptor number and function in rat cortex after ethanol and immobilization stress, Brain . Res., 288, (1-2), 1983, p145 - 149
Caberos, L.P., Lynch, M., Leroy, C., Fenn, G.C. and Littleton J.M., Interaction of ethanol with ionophore A23187 in human platelets and erythrocytes and in rat brain slices, Biochem. Pharmacol., 32, (14), 1983, p2211-2216
Lynch, M. and Littleton, J.M.,, Possible association of alcohol tolerance with increased synaptic Ca2+ sensitivity, Nature, 303, 1983, p175 - 177
SAMUEL, D., LYNCH, M. and LITTLETON, J.M., Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum, Neuropharmacology, 22, (12), 1983, p1413-1415
FENN, G.C., LYNCH, M., NHAMBURO, P.T., CABEROS, L.P. and LITTLETON, J.M., A comparison of effects of ethanol on platelet function and synaptic trasmission, Pharmacology, Biochemisty and Behaviour, 18, Supplement 1., 1983, p37-43
KENNY, M., LYNCH, M. and LEONARD, B.E., Induction of two distinct behavioural responses by chronic treatment with apomorphine, Journal of Neuroscience Research, 5, (1), 1980, p35-42
LYNCH, M. and LEONARD, B.E., Changes in brain gamma aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression., Biochemical Pharmocology, 27, (14), 1978, p1853-1855
LYNCH, M., KENNY, M. and LEONARD, B.E., Effect of D-amphetamine on the behaviour of rats in the "open field": interaction with 4 neuroleptics and changes in biogenic amine metabolism in discrete brain regions., Irish Journal of Medical Science, 147, (10), 1978, p337-350
LYNCH, M. and LEONARD, B.E., Effect of chronic amphetamine administration on the behaviour of rats in the "open field" apparatus: reversal of post-withdrawl depression by 2 antidepressants, J Pharm Pharmacol. , 30, (12), 1978, p798-799
LYNCH, M., KENNY, M. and LEONARD, B.E., Changes in the catecholamine content in 4 regions of the rat brain following acute ampetamine treatment: antagonistic effect of chlorpromazine, I.C.R.S. Med.Sci., 5, 1977, p561
LYNCH, M., KENNY, M. and LEONARD, B.E., Changes in behaviour in rats in the "open field" apparatus after chronic amphetamine administration: acute effects of 3 antidepressants, I.C.R.S. Med. Sci., 5, 1977, pp.571
LYNCH, M., KENNY, M. and LEONARD, B.E., The effect of chronic administration of D-amphetamine on regional changes in catecholamines in the rat brain., Journal of Neuroscience Research, 3, 1977, p.295
Research Expertise
Description
RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.Projects
- Summary
- Current projects are as follows: 1. Analysis of the role of TLR2 activation in driving inflammation and the impact of decreasing activation on cognitive function, glial activation and amyloid pathology in APP/PS1 mice. 2. Investigation of the effects of a small molecule inhibitor of the NLRP3 inflammasome on glial and neuronal function in APP/PS1 mice. 3. Assessment of the impact of infiltrating IFNγ-producing peripheral cells on neuroinflammation and investigation of consequences of inhibiting cell infiltration by FTY720. 4. Investigation of the role of SLAM (Signalling lymphocyte activation molecule) on microglial function. 5. Identification of the metabolic and functional signatures of different microglial phenotypes
Recognition
Representations
2001-2005: Member of Irish government-appointed Commission on Assisted Human Reproduction; Workgroup Chair & member of drafting group for the final report. 2001-2009: Member of Board of Trinity College Institute of Neuroscience 2005-2008: Member of Board of Trinity College Dublin 2006-2009: Director, Trinity College Institute of Neuroscience
Awards and Honours
Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient
Elected to membership of the Royal Irish Academy
Recipient of Tom Connor Distinguished Researcher Award In Neuroscience
Recipient of the Irish Area Section of the Biochemical Society Silver Medal
Elected Fellow of Trinity College, Dublin
Memberships
British Neuroscience Association