Professor Keith Tipton
Fellow Emeritus, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Martignoni M; Benedetti M; Davey GP; Tipton KF; McDonald A, Degradation of thymic humoral factor
Kennedy, C. Brewer, L. Williams, D., Drug interactions, Drug Metabolism Reviews, 48, (7), 2020, p450 - 455
McDonald A.G., Tipton K.F. and Davey G.P., A mechanism for bistability in glycosylation, PLOS Computational Biology, 14, (8), 2018, pe1006348-
McDonald, A.G, Tipton, K.F. and Davey, G.P. , A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts, PLOS Computational Biology, 12, (4), 2016, pe1004844-
Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203
Andrew G. McDonald and Keith F. Tipton, The effects of tyramine and 4-aminophenol on the oscillating peroxidase-oxidase reaction, The Journal of Physical Chemistry B, 118, (1), 2014, p18 - 25
McDonald, A.G., Hayes, J.M., Bezak, T., Głuchowska, S.A., Cosgrave, E.F.J., Struwe, W.B., Stroop, C.J.M., Kok, H., van den Lar, T., Rudd, P.M., Tipton, K.F. and Davey, G.P., Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation, Journal of Cell Science, 127, 2014, p5014 - 5026
Monitoring extracellular amino acid neurotransmitters and hROS by in vivo microdialysis in rats: a practical approach. in, G Giovanni & V. Di Matteo , Microdialysis Techniques in Neuroscience, Neuromethods, New York, USA, Humana Press, 2013, pp225-248 , [M.A. Colivicchi, C. Stefanini, W. Freinbichler, C. Ballini, L. Bianchi, K.F. Tipton and L. Della Corte.]
Andrew G. McDonald and Keith F. Tipton, Fifty-five years of Enzyme classification: advances and difficulties, FEBS Journal, 2013
Enzymes: Irreversible Inhibition. in, A.G. McDonald and K.F. Tipton, Keith F. , Encyclopedia of the Life Sciences (eLS)., Chichester., John Wiley & Sons, Ltd, 2012, [A.G. McDonald and K.F. Tipton.]
Olivieri A, Tipton K, O'Sullivan J, Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine., Biochimica et biophysica acta, 1820, (4), 2012, p482-487
Olivieri A, Rico D, Khiari Z, Henehan G, O'Sullivan J, Tipton K, From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase., Journal of neural transmission (Vienna, Austria : 1996), 118, (7), 2011, p1079-1089
Robert A. Alberty, Athel Cornish Bowden, Robert N. Goldberg, Gordon G. Hammes, Keith Tipton, Hans V. Westerhoff, Recommendations for terminology and databases for biochemical thermodynamics, Biophysical Chemistry, 155, (2-3), 2011, p89-103
Tipton KF, Davey GP, McDonald AG, Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead., International review of neurobiology, 100, 2011, p43-64
Freinbichler W, Colivicchi MA, Stefanini C, Bianchi L, Ballini C, Misini B, Weinberger P, Linert W, Vare"lija D, Tipton KF, Della Corte L, Highly reactive oxygen species: detection, formation, and possible functions., Cellular and molecular life sciences : CMLS, 68, (12), 2011, p2067-2079
Olivieri, A., Tipton. K., Inhibition of bovine plasma semicarbazide-sensitive amine oxidase by caffeine. , Journal of Biochemical and Molecular Toxicology, 25, 2011, p26 - 27
Roberta J Ward, Frederic Lallemand, Philippe de Witte, Robert R Crichton, Jacques Piette, Keith Tipton, Karl Hemmings, Arnaud Pitard, Mike Page, Laura Della Corte, Deanna Taylor, David Dexter, Anti-inflammatory actions of a taurine analogue; ethane β-sultam; in phagocytic cells; in vivo and in vitro, Biochemical Pharmacology, 81, 2011, p743 - 751
Olivieri A, O'Sullivan J, Fortuny LR, Vives IL, Tipton KF, Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions., Biochimica et biophysica acta, 1804, 2010, p941 - 947
Aldo Olivieri, Jeff O'Sullivan, Luis Raimon Alvarez Fortuny, Itziar Larrauri Vives, Keith F. Tipton, Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions, BBA - Proteins and Proteomics, 1804, (4), 2010, p941-947
McDonald, A.G., Tipton, K.F., Stroop, C.J., Davey G.P., GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources., BMC Research Notes, 18, (3), 2010, p1-7
Apweiler, R. Armstrong, R., Bairoch, A., Cornish-Bowden, A., Halling, P.J. Hofmeyr, J.H., Kettner, C... Leyh, T.S., Rohwer J., D. Schomburg, D. Steinbeck C., K. Tipton K., A large-scale protein-function database., Nature Chemical Biology, 6, 2010, p785 - 785
McDonald AG, Tipton KF, Computer-controlled system for the study of oxidase reactions: application to the peroxidase-oxidase oscillator., The Journal of Physical Chemistry. B, 114, (49), 2010, p16244-52
Effects of pH on enzymes in, editor(s)D.L Purich , Enzyme Kinetics and Mechanism, New York, USA, Academic Pres, 2009, pp124 - 178, [Tipton, K.F., McDonald, A.G., Dixon, H.B.F.]
McDonald AG, Tipton KF and Davey GP, Mathematical modelling of metabolism, The Biochemist, 31, 2009, p24 - 27
McDonald, A., Boyce, S., and Tipton, K.F. , ExplorEnz: the primary source of the IUBMB enzyme list, Nucleic Acids Research, 37, (Database Issue), 2009, pD593 - D597
McDonald, Andrew G., Tipton, Keith F. and Boyce, Sinéad, Tracing metabolic pathways from enzyme data , BBA - Proteins & Proteomics, 1794, (9), 2009, p1364-1371
Nomenclature and potential functions of copper amine oxidases. in, editor(s)G. Floris & B. Mondovi , Copper Amine Oxidases, Boca Raton, FL, USA , CRC Press, 2009, pp5 - 17, [S. Boyce, K.F. Tipton, M.I. O'Sullivan, G.P. Davey. M. Motherway Gildea, A.G. McDonald, A. Olivieri, and J. O'Sullivan]
Black WJ, Stagos D, Marchitti SA, Nebert DW, Tipton KF, Bairoch A and Vasilio V., Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature., Pharmocogenetics and Genomica, 2009
Freinbichler, W., Tipton, K.F., Della Corte, L. and Linert, W. , Mechanistic aspects of the Fenton reaction under conditions approximated to the extracellular fluid. , Journal of Inorganic Biochemistry, 103, (1), 2009, p28 - 34
From the enzyme list to pathways and back again in, editor(s)M.G. Hicks & C. Kettner , Proceedings of the 3rd International Beilstein Workshop on Experimental Standard Conditions of Enzyme Characterizations, Frankfurt, Germany, Beilstein Institut, 2008, pp109 - 122, [McDonald, A.G., Tipton, K.F. and Boyce, S. ]
Ballini, C., Della Corte, L., Pazzagli, M., M.A, Colivicchi, M.A., Pepeu, G.. Tipton, K.F. and Giovannini, M.G. , Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory avoidance response in the rat, Journal of Neurochemistry, 106, (3), 2008, p1035 - 1043
Kotera, M., McDonald, A.G., Boyce, S. and Tipton, K.F. , Functional Group and Substructure Searching as a Tool in Metabolomics, PLoS ONE , 3, (2, e1537), 2008, p1-8
Sanz, E., Quintana, A., Battaglia, V., Toninello, A., Hidalgo, J., Ambrosio, S., Valoti, M., Marco, J.L., Tipton, K.F., Unzeta, M.. ., Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP(+)-treated SH-SY5Y human dopaminergic cells, Journal of Neurochemistry, 105, (6), 2008, p2404 - 2417
Kotera, M., McDonald, A.G., Boyce, S. and Tipton, K.F. , Eliciting possible reaction equations and metabolic pathways involving orphan metabolites. , Journal of Chemical Information and Modeling. , 48, (12), 2008, p2335 - 2349
Taylor, C.F., Field, D., Sansone, S.A., Aerts, J., Apweiler, R., Ashburner, M., Ball, C.A., Binz, P.A., Bogue, M., Booth, T., Brazma, A., Brinkman, R.R., Clark, M.A., Deutsch, E.W., Fiehn, O., Fostel, J., Ghazal, P., Gibson, F., Gray, T., Grimes, G., Hancock, J.M., Hardy, N.W., Hermjakob, H., Julian, R.K. Kane, M., Kettner, C., Kinsinger, C., Kolker, E., Kuiper, M., Novère N.L., Leebens-Mack, J., Lewis, S.E., Lord, P., Mallon, A.M., Marthandan, N., Masuya, H., McNally, R., Mehrle, A., Morrison, N., Orchard, S., Quackenbush, J., Reecy, J.M., Robertson, D.G., Rocca-Serra, P., Rodriguez, H., Rosenfelder, H., Santoyo-Lopez, J., Scheuermann, R.H., Schober, D., Smith, B., Snape, J., Stoeckert, C.J., Tipton, K.F., Sterk, P., Untergasser, A., Vandesompele, J. and Wiemann, S. , Promoting coherent minimum reporting requirements for biological and biomedical investigations: The MIBBI project, Nature Biotechnology, 26, (8), 2008, p889 - 896
Freinbichler, W., Bianchi, L., Colivicchi, M.A., Ballini, C., Tipton, K.F., Linert, W. and Della Corte, L. , The detection of hydroxyl radicals in vivo, Journal of Inorganic Biochemistry, 102, (5-6), 2008, p1329 - 1333
Kilbride, S.M., Telford, J.E., Tipton, K.F. and Davey, G.P., Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from depolarized synaptosomesPartial inhibition of complex I activity increases Ca2+-independent glutamate release rates from depolarized synaptosomes, Journal of Neurochemistry, 106, (2), 2008, p826 - 834
Freinbichler, W., Colivicchi, M.A., Fattori, M., Ballini, C., Tipton, K.F., Linert, W. and Della Corte, L., Validation of a robust and sensitive method for detecting hydroxyl radical formation together with evoked neurotransmitter release in brain microdialysis, Journal of Neurochemistry, 105, (3), 2008, p738 - 749
Cornally, D., Mee, B., MacDonaill, C., Tipton, K.F., Kelleher, D., Windle, H.J. and Henehan, G.T.M., Aldo-keto reductase from Helicobacter pylori - role in adaptation to growth at acid pH, FEBS Journal, 275, (12), 2008, p3041 - 3050
Healy, J. and Tipton, K.F., Ceruloplasmin and what it might do., Journal of Neural Transmission, 114, (6), 2007, p777 - 781
Hernandez-Guillamon, M., Bolea, I., Sole, M., Boada, M., Tipton, K.F. and Unzeta, M., Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro. , Journal of Biochemistry (Tokyo), 142, (5), 2007, p571 - 576
Strolin Benedetti, M., Tipton, K.F. and Whomsley., R. , Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?, Fundamamental and Clinical Pharmacology, 21, (5), 2007, p467 - 480
Strolin Benedetti, M., Tipton, K.F., Whomsley, R. and Baltes, E., Factors affecting the relative importance of amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans. , Journal of Neural Transmission, 114, (6), 2007, p787 - 791
G. A. Scalabrino, N. Hogan, K.M.O'Boyle, G.R. Slator, D.J.Gregg, C.M.Fitchett, S.M.Draper, G.W. Bennet, P.M.Hinkle, K.Bauer, Discovery of a Dual Action, First-in-class Peptide that mimics and enhances CNS-mediated actions of Thyrotropin-releasing Hormone , Neuropharmacology, 52, (7), 2007, p1472 - 1481
McDonald, AG., Tipton, K.F., O'Sullivan, J., Olivieri, A., Davey, G. P., Coonan, A.M. and Fu, W., , Modelling the roles of MAO and SSAO in glucose transport., Journal of Neural Transmission, 114, (6), 2007, p783 - 786
McDonald, A.G., Boyce, S., Moss, G.P., Dixon, H.B.F. and Tipton, K.F. , ExplorEnz: a MySQL database of the IUBMB enzyme nomenclature, BMC Biochemistry, 27, (8:14), 2007, p1-7
Boomsma, F. and Tipton, K.F. , Renalase, a catecholamine-metabolising enzyme? , Journal of Neural Transmission, 114, (6), 2007, p775 - 775
Ben Ramadan, Z., Wrang, M.L. and Tipton, K.F. , Species Differences in the Selective Inhibition of Monoamine Oxidase (1-methyl-2-phenylethyl)hydrazine and its Potentiation by Cyanide., Neurochemical Research, 32, (10), 2007, p1783 - 1790
O'Sullivan, J., Davey, G.P., O'Sullivan, M. I. and Tipton, K.F, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase., Journal of Neural Transmission, 114, (6), 2007, p751 - 756
Olivieri, A., Tipton, K. and O'Sullivan, J., L-lysine as a recognition molecule for the VAP-1 function of SSAO., Journal of Neural Transmission, 114, (6), 2007, p747 - 749
Scalabrino, G.A., Hogan, N., O'Boyle, K.M., Slator, G.R., Gregg, D.J., Fitchett, C.M., Draper, S.M., Bennett, G.W., Hinkle, P.M., Bauer, K., Williams, C.H., Tipton, K.F. and Kelly, J.A., Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone. , Neuropharmacology, 52, (7), 2007, p1472 - 1481
Youdim, M.B.H., Edmondson, D. and Tipton, K.F., The therapeutic potential of monoamine oxidase inhibitors., Nature Reviews in Neuroscience, 7, (4), 2006, p295 - 309
O'Sullivan, J., O'Sullivan, M. I., Tipton, K.F. and Davey, G, P., Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine., Journal of Neural Transmission (suppl.), 71, 2006, p105 - 112
J.A. Kelly, G.A. Scalabrino, G.R. Slator, A.A. Cullen, J.F. Gilmer, D.G. Lloyd, G.W. Bennett, K. Bauer, K.F. Tipton and C.H. Williams., Structure-activity studies with high affinity inhibitors of pyroglutamyl-peptidase II., Biochemical Journal, 389, 2005, p569 - 576
B Mee, D Kelleher, J Frias, R Malone, KF Tipton, GT Henehan, HJ Windle, Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme, FEBS J, 272, (5), 2005, p1255 - 1264
Amine Oxidases and Drug Metabolism. in, editor(s)F. Oesch , Proc 15th Int Symp Microsomes and Drug Oxidations, Mainz Germany. , Bologna, Italy , Merimond S.r.l., 2005, pp47 - 54, [K.F. Tipton and M. Strolin Benedetti]
Mee, B., Kelleher, D., Frias, J., Malone, R., Tipton, K.F., Henehan ,G.T. and Windle,H.J., Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori., FEBS JOURNAL, 272, (5), 2005, p1255 - 1264
Apweiler, R., Cornish-Bowden, A., Hofmeyr, J.H., Kettner, C., Leyh, T.S., Schomburg, D. and Tipton, K.F. , The importance of uniformity in reporting protein-function data. , Trends in Biochemical Sciences, 30, 2005, p11 - 12
Enzyme Classification and Nomenclature , Encyclopedia of the Life Sciences, Chichester, John Wiley & Sons, Ltd,, 2005, pp14 pp , [Tipton, K. F. and Boyce, S.]
O'Sullivan, J., Unzeta, M., Healy, J., O'Sullivan, M. I., Davey, G., and Tipton, K. F.,, Semicarbazide-Sensitive Amine Oxidases: Enzymes with Quite a Lot to Do, Neurotoxicology, 25, 2004, p303 - 315
Monoamine oxidases (MAO): Functions in the nervous system. in, editor(s)G. Adelman and B. Smith , Encyclopedia of Neuroscience, 3rd Edition, Amsterdam, Elsevier Science BV, 2004, pp1-17 , [Tipton, K.F., O'Sullivan, J. and Youdim, M.B.H.]
Boyce, S., Tipton, K.F. and McDonald, A.G., Extending enzyme classification with metabolic and kinetic data: Some difficulties to be resolved. , 1st International Beilstein Workshop on Experimental Standard Conditions of Enzyme Characterizations. , Beilstein Institut, Frankfurt, Germany , 5-8 October 2003, edited by M.G. Hicks and C. Kettner , 2004, pp17 - 43
Colivicchi, M.A., Raimondi, L., Bianchi, L., Tipton, K.F., Pirisino, R. and Della Corte, L., Taurine prevents streptozotocin impairment of hormone-stimulated glucose uptake in rat adipocytes. , EUROPEAN JOURNAL OF PHARMACOLOGY, 495, (2-3), 2004, p209 - 215
Tipton, K.F., Boyce, S., O'Sullivan, J., Davey, G.P. and Healy, J., Monoamine oxidases: certainties and uncertainties , Current Medicinal Chemistry , 11, 2004, p1965 - 1982
The effects of two salsolinol derivatives on mitochondrial respiration and the likely nature of any endogenous parkinsonism-inducing toxin. in, editor(s)T.L..Török & I. Klebovich , Design of Monoamine oxidase Inhibitors and their role in neurotransmission (drug development). , Budapest, Medicina Publishing House Co, 2004, pp55 - 77, [Farmer, M.K., Tipton, K.F. and Davey, G.P.]
Bridge, M.H., Williams, E., Lyons, M.E., Tipton, K.F. and Linert. W., Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases., BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1690, (1), 2004, p77 - 84
Bianchi, L., De Micheli, E., Bricolo, A., Ballini, C., Fattori, M., Venturi, C., Pedata, F., Tipton, K. F. and Della Corte, L., Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study, NEUROCHEMICAL RESEARCH, 29, (1), 2004, p325 - 334
Irwin, J. A. and Tipton, K. F., Affinity precipitation methods, Methods Mol Biol, 244, 2004, p205 - 224
Fleischmann, A., Darsow, M., Degtyarenko, K., Fleischmann, W., Boyce, S., Axelsen, K. B., Bairoch, A., Schomburg, D., Tipton, K. F. and Apweiler, R., IntEnz, the integrated relational enzyme database, Nucleic Acids Res, 32, 2004, pD434 - 477
Joyce, O. J. P., Farmer, M. K., Tipton, K. F. and Porter, R. K., Oxidative phosphorylation by in situ synaptosomal mitochondria from whole brain of young and old rats, JOURNAL OF NEUROCHEMISTRY, 86, (4), 2003, p1032 - 1041
O'Sullivan, M., MacDougall, M. B., Unzeta, M., Lizcano J. M. and Tipton K. F., Semicarbazide-sensitive amine oxidases in pig dental pulp, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1647, (1-2), 2003, p333 - 336
Kinetics of Catalyzed Reactions ' Biological in, editor(s)I.T. Horváth , Encyclopedia of Catalysis , John Wiley & Sons, Inc, 2003, pp395 - 471 , [McDonald, A. G. and Tipton, K. F.]
Dalfo, E., Hernandez, M., Lizcano, J. M., Tipton, K. F. and Unzeta, M., Activation of human lung semicarbazide sensitive amine oxidase by a low molecular weight component present in human plasma. , BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1638, (3), 2003, p278 - 286
O'Sullivan, J., O'Sullivan, M., Tipton, K. F., Unzeta, M., Del Mar Hernandez, M. and Davey, G. P., The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1647, (1-2), 2003, p367 - 371
Seymour, C. B., Mothersill, C., Mooney, R., Moriarty, M. and Tipton, K. F., Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity, BRITISH JOURNAL OF CANCER, 89, (10), 2003, p1979 - 1986
Tipton, K. F., O'Sullivan, M. P., Davey, G. P. and O'Sullivan, J. , It can be a complicated life being an enzyme, Biochem. Soc. Trans, 31, 2003, p711 - 715
Fitzgerald, D. H. and K. F. Tipton, K. F., Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO). , J. Neural Transm, 109, 2002, p251-265
Principles of enzyme assay and kinetic studies in, editor(s)R, Eisenthal and M.J. Danson , Enzyme Assays: A Practical Approach , Oxford University Press , 2002, pp1 - 47, [K.F. Tipton]
O'Sullivan, M., Tipton, K. F. and McDevitt, W. E. , Immunolocalization of semicarbazide-sensitive amine oxidase in human dental pulp and its activity towards serotonin, Oral Biol, 47, 2002, p399 - 406
Youdim, M. B. H. and K.F. Tipton, K. F., Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. , Parkinsonism Relat. Disord, 8, 2002, p247 - 253
Principles of enzyme assay and kinetic studies in, editor(s)R, Eisenthal and M.J. Danson , Enzyme Assays: A Practical Approach , Oxford University Press , 2002, pp1 - 47, [K.F. Tipton]
O'Byrne, M. B. and Tipton, K. F. , Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP+) toxicity in vitro, J. Neural Transm, 109, 2002, p585 - 596
Quinlan, C.A., O'Sullivan, M.I., Zisterer, D.M. & Tipton, K.F., In vitro cytotoxicity of a composite resin and compomer., International Endodontic Journal, 35, (1), 2002, p47 - 55
Youdim, M. B. H. and Tipton, K. F., Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. , Parkinsonism Relat. Disord, 8, 2002, p247 - 253
Biogenic amines. diet and the properties of amine oxidases in, editor(s)D. M. L. Morgan, T. Hirvi, G. Dandrifosse, P. Deloyer and A. White , Biogenically Active Amines in Food, Brussels, Belgium , European Communities Publication Office, , 2002, pp117 - 121, [Tipton, K. F.]
Della Corte, L., Crichton, R. R., Duburs, G., Nolan, K., Tipton, K. F., Tirzitis, G. and R.J, The use of taurine analogues to investigate taurine functions and their potential therapeutic applications, Amino Acids , 23, 2002, p367 - 379
Hayes, J. P. and Tipton, K. F., Interactions of the neurotoxin 6-hydroxydopamine with glyceraldehyde-3-phosphate dehydrogenase, Toxicology Letters , 128, 2002, p197-206
Quinlan, C. A., Zisterer, D. M., Tipton, K. F. and O'Sullivan, M. I., A study of the in vitro cytotoxicity of a composite resin and compomer , Int. Endod. J., 35, 2002, p47 - 55
Hayes, J., Tipton, K. F., Bianchi, L. and Della Corte, L., Complexities in the neurotoxic actions of 6-hydroxydopamine in relation to thecytoprotective properties of taurine, Brain Research Bulletin, 55, 2001, p239-245
M. Marangolo, M. M. McGee, K. F. Tipton, D. C. Williams and D. M. Zisterer, Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B, Neurotox Research, 3, (4), 2001, p397-409
McDonald, A. G., Boyce, S., Connolly, J., Kazic, T., Wise, W. and Tipton, K. F., Metabolic systems and the behaviour of neuronal systems, Proceedings of the First World Congress of Neuroinfomatics, Vienna, Austria, edited by F. Rattay , Argesima/ASIM Verlag, 2001, pp308 - 316
Marangolo, M., Tipton, K. F., McGee, M. M., Williams D. C. and Zisterer, D. M., Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinase and nuclear factor kappa B, Neurotoxicity Res, 3, 2001, p397 - 409
Cunningham, C. and Strolin Benedetti, M. , Oxidative stress and radical detection, Food Antioxidants and Human Health (EC FAIR Conference)., Siena, Italy , edited by G. Sgaragli and M. Valoti , Casa Editrice I Mori, 2001, pp47 - 56
Alcohol and Alcoholism , (2001), Tipton, K. F., [Chief ed.], 1996-2001
Amine Oxidases and the metabolism of xenobiotics in, editor(s)C. Ioannides , Enzyme Systems that Metabolise Drugs and Other Xenobiotics, Chichester, UK , John Wiley & Sons, Ltd, 2001, pp95 -146 , [Tipton, K. F. and Strolin Benedetti, M.]
Lizcano, J. M., Unzeta. M. and Tipton, K. F., Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes, 351, 2000, p789 - 794
Monoamine oxidase assays. in, editor(s)S.J. Enna, M. Willias , J. W. Ferkany, T, Kenakin, R. E. Porsolt and J.P. Sullivan , Current Protocols in Pharmacology, New York , John Wiley , 2000, pp3.6.1 - 3.6.42 , [Tipton, K. F., Davey, G. and Motherway, M.]
O'Byrne, M. B., Bolam, J. P., Hanley, J. J. and Tipton, K. F. , Tyrosine-hydroxylase immuno-reactive cells in the rat striatum following treatment with MPP+. , Advances in Experimental Medicine and Biology, 483, 2000, p369 - 374
Lizcano, J. M., Unzeta, M. and Tipton, K. F., A spectrophotometric method for determining the oxidative deamination of methylamine by the amine oxidases, Analyt. Biochem, 286, 2000, p75 - 79
Cunningham, C. M. and Tipton, K. F., Metabolism of taurine to sulphoacetaldehyde during oxidative stress, Advances in Experimental Medicine and Biology, 483, 2000, p383 - 388
Capodarca, S., Cunningham, C. M., Bartolini, P., Tipton, K. F., Della Corte, L., Bianchi, L., Ward, R. J., Dachour, A., Quertemont, E., Lallemand, F. and De Witte, P., Effects of ethanol and glutamate agonist infusion on the outflow of sulphoacetaldehyde: Microdialysis studies, Advances in Experimental Medicine and Biology, 483, 2000, p397 - 304
Palmi, M., Youmbi, G., Sgaragli, G. P., Meini, A., Benocci, A., Fusi, F., Frosini, M., Della Corte, L., Davey, L. and K.F. Tipton, K. F., The mitochondrial permeability transition and taurine, Advances in Experimental Medicine and Biology, 483, 2000, p87 - 96
O'Byrne, M. B. and Tipton, K. F., Taurine-induced attenuation of MPP+ neurotoxicity in vitro: a possible role for the GABA(A) subclass of GABA receptors, J. Neurochem, 74, 2000, p2087 - 2093
Kelly, J. A., Slator, G. R., Tipton, K. F., Williams, C. H. and Bauer, K., Kinetic Investigation of the Specificity of Porcine Brain Thyrotropin-releasing Hormone-degrading Ectoenzyme for Thyrotropin-releasing Hormone-like Peptides, J. Biol. Chem, 275, 2000, p16746 - 16751
Valoti, M., Fusi, F., Frosini, M., Pessina, F., Tipton, K. F. and Sgaragli, G. P., Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl. , Eur. J. Pharmacol, 391, 2000, p199 - 206
Inhibitors of monoamine oxidase and the pressor response to dietary amines in, editor(s)K. Magyar and E.S. Vizi , Milestones in Monoamine Oxidase Research: Discovery of (-)-Deprenyl, Budapest, Hungary, Medicina Publishing House, 2000, pp19 - 32, [Tipton, K. F. ]
Davey, G. P. and Tipton, K. F., Mitochondria, cell death and DNA damage. , Radiation Research , 2, 2000, p390 - 394
Boyce, S. and Tipton, K. F., History of the enzyme nomenclature system, Bioinformatics, 16, 2000, p34 - 40
Enzyme Classification and Nomenclature in, Encyclopedia of Life Sciences, UK, Macmillan Reference Co, 2000, ppArticle 710, 13 pp , [Tipton, K. F. and Boyce, S.]
Taurine 4: Taurine and Excitable Tissues in, editor(s)L. Della Corte, R. J. Huxtable, G.P. Sgaragli and K. F. Tipton , Advances in Experimental Medicine and Biology, Dordrecht, The Netherlands , Kluwer Academic/Plenum Publishers, 2000, pp1 - 664, [ ]
Bianchi, L., Della Corte, L. and Tipton, K. F., Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and GABA during microdialysis and from superfused brain slice.s, J. Chromatogr. B, 723, 1999, p47 - 59
Bartolini, P., Tipton, K. F., Bianchi, L., Stephenson, D., Cunningham, C., and Della Corte, L., Determination of monoamine oxidase activity by hplc with fluorimetric detection. , Neurobiology, 7, 1999, p159 - 174
M .Palmi, G.T. Youmbi, F. Fusi , G.P. Sgaragli, H.B.F.Dixon, M. Frosini and K.F. Tipton, Potentiation of mitochondrial Ca2+ sequestration by taurine, Biochem. Pharmacol. , 58, 1999, p1123 - 31
Ben Ramadan, Z., Dostert, P. and Tipton, K. F., Some Peculiar aspects of monoamine oxidase inhibition, Neurobiology, 7, 1999, p123 - 134
Porter, R. K., Joyce, O. J. P., Farmer, M. K., Heneghan, R., Tipton, K. F., Andrews, J. F., McBennet, A. M., Lund, M. D., Jensen, C. H. and Melia, H. P., Indirect measurement of mitochondrial proton leak and its application. , Int. J. Obesity , 23, 1999, p1 - 7
McDonald, A. G. and Tipton, K. F., Kinetics for the numerically challenged, The Biochemist , 21, 1999, p18 - 23
Monoamine oxidases (MAO): Functions in the nervous system in, editor(s)G. Adelman and B. Smith , Encyclopedia of Neuroscience, Amsterdam, Elsevier Science BV, 1999, [Tipton, K. F., O'Brien, E. M. and Youdim, M. B. H.]
Farren, C. K. and Tipton, K. F., Trait markers for alcoholism: clinical utility. , Alc. Alcoholism , 34, 1999, p649 - 665
Monoamine oxidases (MAO): Functions in the nervous system in, editor(s)G. Adelman and B. Smith , Encyclopedia of Neuroscience, Amsterdam, Elsevier Science BV, 1999, [Tipton, K. F., O'Brien, E. M. and Youdim, M. B. H.]
Vasilou, V., Bairoch, A., Tipton, K. F. and Nebert, D. W., Eukaryotic aldehyde dehydrogenase (ALDDH) genes: human polymorphisms and recommended nomenclature based on divergent evolution and chromosome mapping. , Pharmacogenetics , 9, 1999, p421 - 434
Kelly, J. A., Slator, G. R., Tipton, K. F., Williams, C. H. and Bauer, K., Development of a continuous, fluorometric coupled enzyme assay for thyrotropin-releasing hormone-degrading ectoenzyme, Anal. Biochem, 274, 1999, p195 - 202
Bartolini B, Tipton KF, Bianchi L, Stephenson D, Cunningham C, Della Corte L., Determination of monoamine oxidase activity by HPLC with fluorimetric detection, Neurobiology (Bp), 79, ((2)), 1999, p109-21
Strolin Benedetti, M. and Tipton, K. F., nvolvement of monooxygenases and amine oxidases in hydroxyl radical generation in vivo, Neurobiology , 7, 1999, p123 - 134
Lizcano, J. M., Tipton, K. F. and Unzeta, M., Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung, Biochem. J. , 331, 1998, p69 - 78
Farren, C. K., Clare, A. W., Tipton, K. F., and Dinan, T. G., Platelet MAO activity in subtypes of alcoholics and controls in a homogenous, J. Psychiatr. Res. , 32, 1998, p49 - 54
J.P.M. Finberg, M.B.H. Youdim, P. Riederer and K.F.Tipton (Eds), MAO ' The Mother of all Amine Oxidases, Vienna, Austria , Springer-Verlag, 1998, xix plus 355pp
Strolin Benedetti, M., Sanson, M., Bona, G., Gallina, M., Persiani S. and Tipton, K. F. , The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver., J. Neural Transm. (Suppl.), 52, 1998, p233 - 238
Glinka, Y., Tipton, K. F. and Youdim, M. B. H. , Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine, Eur. J. Pharmacol, 351, 1998, p121 - 129
Ward, R. J., McCrodden, J., Tipton, K., Sherwood, R., Keating, J., Peters, T.J. and de Witte. P., Biochemical and genetic studies on Caucasian subjectswith ethanol-induced flushing reaction, Addiction Biology , 3, 1998, p465 - 472
Fitzgerald, D., Tipton, K. F. and Lyles, G. A., Studies on the behaviour of semicarbazide-sensitive amine oxidases in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine. , J. Neural Transm. (Suppl.) , 52, 1998, p259 - 264
Cunningham, C., Tipton, K. F. and Dixon, H. B. F. , Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress, Biochem. J. , 330, 1998, p933 - 937
Strolin Benedetti, M., Sanson, M., Bona, G., Gallina, M., Persiani, S. and K.F. Tipton, K. F. , The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver, Neural Transm. (Suppl.), 52, 1998, p251 - 257
Colm Cunningham, Keith F. Tipton and Henry B.F. Dixon, Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress, Biochemical Journal, 330, 1998, p939-945.
Analysis of salsolinols, endogenous neurotoxins, in human materials in, editor(s)G.A. Qureshi, H. Parvez, P. Caudy and S. Parvez , Neurochemical markers of degenerative nervous diseases and drug addiction., The Netherlands, VSP,, 1998, pp423 - 460 , [Naoi, M., Maruyama, W., Matsubara, K., Tipton, K. F., Strolin Benedetti, M. and Parvez, H.]
Strolin Benedetti. M. and Tipton. K. F. , Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics, J. Neural Transm. (Suppl.) , 52, 1998, p149 - 171
Farren, C. K., Clare, A. W., K.F. Tipton and T.G. Dinan, Platelet MAO activity in subtypes of alcoholics and controls in a homogenous, J. Psychiatr. Res. , 32, 1998, p49 - 54
Antagonism by taurine of the ruthenium red-induced and 6-hydroxydopamine plus 1-methyl-4-phenylpyridinium-induced Ca2+ release from rat liver mitochondria in, editor(s)S. Schaffer, J.B. Lombardini and R.J. Huxtable , Taurine 3: cellular and regulatory mechanisms, New York, Plenum Press, 1998, pp91 - 98 , [Palmi, M., Youmbi, G., Fusi, F., Frosini, M., Sgaragli, G. P., Della Corte, L. and Tipton, K. F. ]
Essays in Biochemistry, (1995), Tipton, K. F., [Chief ed.], 1985-95
Journal of Neurochemistry , (1991), Tipton, K. F., [Chief ed.], 1983-91
Journal of Enzyme Inhibition; Journal of Neural Transmission , , 1990
Biochimica et Biophysica Acta , , 1985
Non-Peer-Reviewed Publications
Biochemical Journal , London, The Biochemical Society - Portland Press, [Editorial Board], -2004
Biochemical Pharmacology [1970-2004], , [eds.]
Research Expertise
Description
Enzymology: regulation, kinetics, inhibition, isolation, applications. Enzyme bioinformatics: metabolic analysis and simulation. Systems biology. Neurochemistry: depression, degenerative diseases and 'neuroprotection'. Biochemical Pharmacology: drug design, ethanol.Recognition
Representations
Molecular Enzymology Group (Chairman), (Biochemical Society)
Neurochemical Group (Chairman) (Biochemical Society)
Publications Board, (Biochemical Society)
Institute of Biology of Ireland (Chairman)
Institute of Biology of Ireland (President)
Biochemical Society (Committee)
International Society for Neurochemistry (Publications Committee)
International Union of Biochemistry & Molecular Biology: Special Interest Group on Enzymology (Chairman )
Irish Society for Toxicology (Vice-president)
Irish Society for Toxicology (President)
Beilstein International Committee on Standards for Reporting of Enzymology Data
IUBMB-IUPAC Joint Committee on Biochemical Nomenclature (responsible for Enzyme Nomenclature, Classification & Bioinformatics)
Medical Research Council (U.K.) Neurosciences Grants Committee
Multiple Sclerosis Society of Ireland: Research Committee
Member of the International Advisory Committee to the HUGO Gene Nomenclature Committee
European Society for Neurochemistry (Council)
Health Research Board (Neurosciences & Mental Health Committee)
Awards and Honours
M.R.I.A. Royal Irish Academy
RIA Biochemistry Medal, Royal Irish Academy
Memberships
International Union of Biochemistry and Molecular Biology (IUBMB)
Irish Neurosciences Discussion Group
Hungarian Pharmacological Society (Honorary Member)