Dr. Elaine Kenny
Adjunct Associate Professor, Trinity Translational Medicine Institute
Publications and Further Research Outputs
Peer-Reviewed Publications
Hong Lee, S., Byrne, E.M., Hultman, C.M., Kähler, A., Vinkhuyzen, A.A., Ripke, S., Andreassen, O.A., Frisell, T., Gusev, A., Hu, X., Karlsson, R., Mantzioris, V.X., McGrath, J.J., Mehta, D., Stahl, E.A., Zhao, Q., Kendler, K.S., Sullivan, P.F., Price, A.L., O'Donovan, M., Okada, Y., Mowry, B.J., Raychaudhuri, S., Wray, N.R., Agartz, I., Amin, F., Azevedo, M.H., Bass, N., Black, D.W., Blackwood, D.H.R., Bruggeman, R., Buccola, N.G., Choudhury, K., Cloninger, C.R., Corvin, A., Craddock, N., Daly, M.J., Datta, S., Donohoe, G.J., Duan, J., Dudbridge, F., Fanous, A., Freedman, R., Freimer, N.B., Friedl, M., Gill, M., Gurling, H., Haan, L.D., Hamshere, M.L., Hartmann, A.M., Holmans, P.A., Kahn, R.S., Keller, M.C., Kenny, E., Kirov, G.K., Krabbendam, L., Krasucki, R., Lawrence, J., Lencz, T., Levinson, D.F., Lieberman, J.A., Lin, D.-Y., Linszen, D.H., Magnusson, P.K.E., Maier, W., Malhotra, A.K., Mattheisen, M., Mattingsdal, M., McCarroll, S.A., Medeiros, H., Melle, I., Milanova, V., Myin-Germeys, I., Neale, B.M., Ophoff, R.A., Owen, M.J., Pimm, J., Purcell, S.M., Puri, V., Quested, D.J., Rossin, L., Ruderfer, D., Sanders, A.R., Shi, J., Sklar, P., St Clair, D., Scott Stroup, T., Van Os, J., Visscher, P.M., Wiersma, D., Zammit, S., Byerley, W., Cahn, W., Cantor, R.M., Cichon, S., Cormican, P., Curtis, D., Djurovic, S., Escott-Price, V., Gejman, P.V., Georgieva, L., Giegling, I., Hansen, T.F., Ingason, Andrés, Kim, Y., Konte, B., Lee, P.H., McIntosh, A., McQuillin, A., Morris, D.W., Nöthen, M.M., O'Dushlaine, C., Olincy, A., Olsen, L., Pato, C.N., Pato, M.T., Pickard, B.S., Posthuma, D., Rasmussen, H.B., Rietschel, M., Rujescu, D., Schulze, T.G., Silverman, J.M., Thirumalai, S., Werge, T., Louis Bridges, S., Choi, H.K., Coenen, M.J.H., De Vries, N., Dieud, P., Greenberg, J.D., Huizinga, T.W.J., Padyukov, L., Siminovitch, K.A., Tak, P.P., Worthington, J., De Jager, P.L., Denny, J.C., Gregersen, P.K., Klareskog, L., Mariette, X., Plenge, R.M., Van Laar, M., Van Riel, P., New data and an old puzzle: The negative association between schizophrenia and rheumatoid arthritis, International Journal of Epidemiology, 44, (5), 2015, p1706-1721
Aloraifi F, McDevitt T, Martiniano R, McGreevy J, McLaughlin R, Egan CM, Cody N, Meany M, Kenny E, Green AJ, Bradley DG, Geraghty JG, Bracken AP., Detection of novel germline mutations for breast cancer in non-BRCA1/2 families., FEBS J., 282, (17), 2015, p3424 - 3437
Andreev D., O'Connor P., Fahey C., Kenny E., Terenin I., Dmitriev S., Cormican P., Morris D., Shatsky I., Baranov P., Translation of 5' leaders is pervasive in genes resistant to eIF2 repression, eLife, 4, 2015, pe03971
Kenny EM, Cormican P, Furlong S, Heron E, Kenny G, Fahey C, Kelleher E, Ennis S, Tropea D, Anney R, Corvin AP, Donohoe G, Gallagher L, Gill M, Morris DW, Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders., Molecular psychiatry, 19, 2014, p872-879
Morris DW, Pearson RD, Cormican P, Kenny EM, O'Dushlaine CT, Perreault LP, Giannoulatou E, Tropea D, Maher BS, Wormley B, Kelleher E, Fahey C, Molinos I, Bellini S, Pirinen M, Strange A, Freeman C, Thiselton DL, Elves RL, Regan R, Ennis S, Dinan TG, McDonald C, Murphy KC, O'Callaghan E, Waddington JL, Walsh D, O'Donovan M, Grozeva D, Craddock N, Stone J, Scolnick E, Purcell S, Sklar P, Coe B, Eichler EE, Ophoff R, Buizer J, Szatkiewicz J, Hultman C, Sullivan P, Gurling H, McQuillin A, St Clair D, Rees E, Kirov G, Walters J, Blackwood D, Johnstone M, Donohoe G, O'Neill FA, Kendler KS, Gill M, Riley BP, Spencer CC, Corvin A, An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis., Human molecular genetics, 23, (12), 2014, p3316-26
Douglas A., Vance D., Kenny E., Morris D., Maxwell A., Maxwell A., McKnight A., Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population, Scientific Reports, 4, 2014
Rolfe RA, Kenny EM, Cormican P, Murphy P, Transcriptome analysis of the mouse E14.5 (TS23) developing humerus and differential expression in muscle-less mutant embryos lacking mechanical stimulation., Genomics data, 2, 2014, p32-6
Rolfe RA, Nowlan NC, Kenny EM, Cormican P, Morris DW, Prendergast PJ, Kelly D, Murphy P., Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways., BioMedCentral Genomics, 15, 2014, p1 - 23
Quinn EM, Cormican P, Kenny EM, Hill M, Anney R, Gill M, Corvin A, Morris DW. , Development of strategies for SNP detection in RNA-seq data: application to lymphoblastoid cell lines and evaluation using 1000 genomes data., PLos One, 2013
Kenna KP, McLaughlin RL, Byrne S, Elamin M, Heverin M, Kenny EM, Cormican P, Morris DW, Donaghy CG, Bradley DG, Hardiman O, Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing., Journal of medical genetics, 50, (11), 2013, p776-83
Lee, S.H., Ripke, S., Neale, B.M., (...), Kendler, K.S., Wray, N.R., Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs, Nature Genetics , 45, (9), 2013, p984-994
Lips ES, Cornelisse LN, Toonen RF, Min JL, Hultman CM, Holmans PA, O'Donovan MC, Purcell SM, Smit AB, Verhage M, Sullivan PF, Visscher PM, Posthuma D, Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia., Molecular Psychiatry, 17, (10), 2012, p996-1006
Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG, Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows., BMC genomics, 13, (1), 2012, p489
Connell S, Meade KG, Allan B, Lloyd AT, Kenny E, Cormican P, Morris DW, Bradley DG, O'Farrelly C, Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing., PloS one, 7, (8), 2012, pe40409
Kenny EM, Cormican P, Gilks WP, Gates AS, O'Dushlaine CT, Pinto C, Corvin AP, Gill M, Morris DW, Multiplex Target Enrichment Using DNA Indexing for Ultra-High Throughput SNP Detection., DNA research : an international journal for rapid publication of reports on genes and genomes, 18, (1), 2011, p31-38
Anney RJ, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L; Autism Genome Project, Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders., Eur J Human Genetics, 19, (10), 2011, p1082 - 1089
Hill MJ, Kenny E, Roche S, Morris DW, Corvin A, Hawi Z, Gill M, Anney RJ, Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: evidence of cis-acting variation and tissue specific regulation., Psychiatric genetics, 21, (6), 2011, p281-286
Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J, Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Chróinín MN, Kennedy BN, Lynch S, Green A, Ennis S, First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype., Human mutation, 32, (12), 2011, p1417-26
O'Dushlaine C, Kenny E, Heron E, Donohoe G, Gill M, Morris D, Consortium IS, Corvin A, Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility., Molecular Psychiatry, 16, (3), 2011, p286-292
Fitzpatrick DA, O'Brien J, Moran C, Hasin N, Kenny E, Cormican P, Gates A, Morris DW, Jones GW, Assessment of Inactivating Stop Codon Mutations in Forty Saccharomyces cerevisiae Strains: Implications for [PSI] Prion- Mediated Phenotypes., PLoS One, 6, (12, e28684), 2011
Raychaudhuri S, Korn JM, McCarroll SA, International Schizophrenia Consortium, Altshuler D, Sklar P, Purcell S, Daly MJ, Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function., PLoS genetics, 6, (9, e1001097), 2010
International Schizophrenia Consortium, Common polygenic variation contributes to risk of schizophrenia and bipolar disorder., Nature, 460, (7256), 2009, p748-752
O'Dushlaine C, Kenny E, Heron EA, Segurado R, Gill M, Morris DW, Corvin A, The SNP ratio test: pathway analysis of genome-wide association datasets., Bioinformatics, 2009
Yang MS, Morris DW, Kenny E, O'Dushalaine CT, Schwaiger S, Nangle, JM, Clarke S, Scully P, Quinn J, Meagher D, Baldwin P, Crumlish N, O'Callaghan E, Waddington JL, Gill M, Corvin A, Chitinase-3-Like1 (CHI3L1) Gene and Schizophrenia: Genetic Association and a Potential functional Mechanism. , Biological Psychaitry, 64, (2), 2008, p98 - 103
Anney, RJ, Kenny, E, O'Dushlaine, CT, Lasky-Su, J, Franke, B, Morris, DW, Neale, BM, Asherson, P, Faraone, SV, Gill, M, Non-random error in genotype calling procedures: Implications for family-based and case-control genome-wide association studies., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B, (8), 2008
Anney, RJ, Lasky-Su, J, O'Dúshláine, C, Kenny, E, Neale, BM, Mulligan, A, Franke, B, Zhou, K, Chen, W, Christiansen, H, Arias-Vásquez, A, Banaschewski, T, Buitelaar, J, Ebstein, R, Miranda, A, Mulas, F, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, J, Sonuga-Barke, E, Steinhausen, H, Asherson, P, Faraone, SV, Gill, M, Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B, (8), 2008
Lorraine O'Driscoll*, Elaine Kenny*, Jai P Mehta, Padraig Doolan, Helena Joyce, Patrick Gammell, Arnold Hill, Brendan O'Daly, Donal O'Gorman and Martin Clynes, Feasibility and Relevance of Global Expression Profiling of Gene Transcripts in Serum from Breast Cancer Patients Using Whole Genome Microarrays and Quantitative RT-PCR, Cancer Genomics and Proteomics, 5, 2008
International Schizophrenia Consortium, Rare chromosomal deletions and duplications increase risk of schizophrenia., Nature, 455, (7210), 2008, p237 - 241
Martinez V, Kennedy S, Doolan P, Gammell P, Joyce H, Kenny E, Prakash Mehta J, Ryan E, O'Connor R, Crown J, Clynes M, O'Driscoll L., Drug metabolism-related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue., Breast Cancer Research and Treatment, 2007
Roy S, Kenny E, Kennedy S, Larkin A, Ballot J, Perez De Villarreal M, Crown J, O'Driscoll L., MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer, Anticancer Research, 27, (3A), 2007, p1325 - 1330
O'Driscoll L,* Kenny E,* Perez de Villarreal M, Clynes M., Detection of Specific mRNAs in Culture Medium Conditioned by Human Tumour Cells: Potential for New Class of Cancer Biomarkers in Serum , Cancer Genomics and Proteomics, 2, 2005, p43 - 52