Professor Colin Doherty
Professor Consultant, Clinical Medicine
Head of School of Medicine, School Office - Medicine
Biography
Colin Doherty holds the Ellen Mayston Bates Chair in Epileptology at Trinity College Dublin School of Health Sciences.He is a Consultant Neurologist and Director of the Epilepsy Service at St James's Hospital, Dublin and the Ellen Mayston Bates, Professor of Epileptology at TCD. His undergraduate degree was awarded by UCD (1991) and he trained in Medicine and Neurology at St Vincent's and Beaumont Hospitals an later at the Partners Neurology Residency Programme at Harvard Medical School, Boston (Brigham and Women's Hospital and Massachusetts General Hospital) where he was Chief Resident in my final year (1998-2001). He has completed Fellowships in Epilepsy and Cognition at MGH (2001-2003). He has published widely in the areas of brain imaging in epilepsy, the genetics of epilepsy, functional imaging of language, dementia, clinical neurology and epileptology and traumatic brain injury. In the last few years hh has become interested in the challenges of population health, health services research and care delivery in epilepsy. He published recently on national issues regarding epilepsy care including; evidence based pathways, national mortality estimates, hospital access restrictions and national prescribing rates. He has 105 peer reviewed publications, 4211 citations, a H-index of 35 and i10index of 78. Between co-applicant, Co-PI and PI grant applications he has been collaboratively responsible for >7 Million Eu in funding I has authored chapters in three textbooks and co-edited one.
He was a member of the Irish government's expert group on resource allocation in the health sector (2011). He was a member of the National Clinical Effectiveness Committee in Ireland since its inception in 2011 to 2015 and represented the RCPI on The Irish Patient Safety Steering Group 2012-2016. He was a board member of the Health Research Board (2010-15) and is a founder member and Medical Director of Epilepsy Research Ireland (ERI). He is the Irish representative to the International League Against Epilepsy (ILAE) committee for the Global Campaign Against Epilepsy and a co-applicant on a large EU funded study on the epidemiology of epilepsy in Europe (ESBASE). He was National Clinical Lead for the Epilepsy Care Programme in Ireland from 2010-2018, with a charge to develop epilepsy services nationally to improve quality of care and access for patients. He has recently moved from that role to take up a specific remit around Women's Health in Epilepsy with the evolution of the Valproate in Pregnancy story.
he states that he has learned a lot in the last five years about the urgent issue of healthcare reform and see medical education, both postgraduate and undergraduate in urgent need of firstly protection of its core mission and values but also innovation and development to meet the challenges of 21st century medical care: Amongst the challenges are underpinning the funding of basic, translation and clinical research; Teamwork and its effect of professionalism, the role of the patient in the design and delivery of healthcare, and the rise of technology.
Publications and Further Research Outputs
Peer-Reviewed Publications
Greene C., Connolly R., Brennan D., Laffan A., O'Keeffe E., Zaporojan L., O'Callaghan J., Thomson B., Connolly E., Argue R., Meaney J.F.M., Martin-Loeches I., Long A., Cheallaigh C.N., Conlon N., Doherty C.P., Campbell M., Correction to: Blood"brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment (Nature Neuroscience, (2024), 27, 3, (421-432), 10.1038/s41593-024-01576-9), Nature Neuroscience, 27, (5), 2024, p1019-
Quigley, S., Asad, M., Doherty, C., Byrne, D., Cronin, S., Kearney, H., Concurrent diagnoses of Tuberous sclerosis and multiple sclerosis, Multiple Sclerosis and Related Disorders, 71, 2023
Gander, L., Stanila, R., Doran, E., Crowley, K., Ann Healy, L., Gough, A., Sinnott, C., Behan, C., Wilson, S., Cunningham, D., Kurian, S., Cope, A., Laffan, A., O'Rourke, D., Zaporojan, L., Doherty, C.P., Living with epilepsy during COVID-19 pandemic restrictions: A longitudinal perspective, Epilepsy and Behavior, 142, 2023
Behan, C., Hynes, S., Ennis, P., Khalil, M.I., Hogan, J., Brett, F., Sweeney, K., Kilbride, R., Doherty, C.P., Neurosurgery for intractable epilepsy in pregnancy: A case report, Epilepsy and Behavior Reports, 23, 2023
Perucca, P., Stanley, K., Harris, N., McIntosh, A.M., Asadi-Pooya, A.A., Mikati, M.A., Andrade, D.M., Dugan, P., Depondt, C., Choi, H., Heinzen, E.L., Cavalleri, G.L., Buono, R.J., Devinsky, O., Sperling, M.R., Berkovic, S.F., Delanty, N., Goldstein, D.B., O'Brien, T.J., Andrade, D., Sen, A., Bazil, C.W., Boland, M., Cavalleri, G., Choi, H., Colombo, S., Costello, D., Delanty, N., Depondt, C., Devinsky, O., Doherty, C.P., Dugan, P., Frankel, W., Goldstein, D., Heinzen, E., Johnson, M., Kwan, P., Marson, T., McCormack, M., Mikati, M., O'Brien, T., Ottman, R., Pandolfo, M., Perucca, P., Petrovski, S., Radtke, R., Rees, M., Sadoway, T., Valley, N., Walley, N., Wood, N., Zuberi, S., Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy, Annals of Neurology, 93, (4), 2023, p752-761
Park, B.-Y., Larivière, S., Rodríguez-Cruces, R., Royer, J., Tavakol, S., Wang, Y., Caciagli, L., Caligiuri, M.E., Gambardella, A., Concha, L., Keller, S.S., Cendes, F., Alvim, M.K.M., Yasuda, C., Bonilha, L., Gleichgerrcht, E., Focke, N.K., Kreilkamp, B.A.K., Domin, M., Von Podewils, F., Langner, S., Rummel, C., Rebsamen, M., Wiest, R., Martin, P., Kotikalapudi, R., Bender, B., O'Brien, T.J., Law, M., Sinclair, B., Vivash, L., Kwan, P., Desmond, P.M., Malpas, C.B., Lui, E., Alhusaini, S., Doherty, C.P., Cavalleri, G.L., Delanty, N., Kälviäinen, R., Jackson, G.D., Kowalczyk, M., Mascalchi, M., Semmelroch, M., Thomas, R.H., Soltanian-Zadeh, H., Davoodi-Bojd, E., Zhang, J., Lenge, M., Guerrini, R., Bartolini, E., Hamandi, K., Foley, S., Weber, B., Depondt, C., Absil, J., Carr, S.J.A., Abela, E., Richardson, M.P., Devinsky, O., Severino, M., Striano, P., Parodi, C., Tortora, D., Hatton, S.N., Vos, S.B., Duncan, J.S., Galovic, M., Whelan, C.D., Bargalló, N., Pariente, J., Conde-Blanco, E., Vaudano, A.E., Tondelli, M., Meletti, S., Kong, X.-Z., Francks, C., Fisher, S.E., Caldairou, B., Ryten, M., Labate, A., Sisodiya, S.M., Thompson, P.M., Mcdonald, C.R., Bernasconi, A., Bernasconi, N., Bernhardt, B.C., Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy, Brain, 145, (4), 2022, p1285-1298
Behan, C., Davis, R., Vasseghi, M., Moloney, P., Amin, S., Delanty, N., Doherty, C.P., Tuberous Sclerosis: A Rare Disease with an Orphan Complex, Irish medical journal, 115, (7), 2022, p635
Altmann, A., Ryten, M., Di Nunzio, M., Ravizza, T., Tolomeo, D., Reynolds, R.H., Somani, A., Bacigaluppi, M., Iori, V., Micotti, E., Di Sapia, R., Cerovic, M., Palma, E., Ruffolo, G., Botía, J.A., Absil, J., Alhusaini, S., Alvim, M.K.M., Auvinen, P., Bargallo, N., Bartolini, E., Bender, B., Bergo, F.P.G., Bernardes, T., Bernasconi, A., Bernasconi, N., Bernhardt, B.C., Blackmon, K., Braga, B., Caligiuri, M.E., Calvo, A., Carlson, C., Carr, S.J.A., Cavalleri, G.L., Cendes, F., Chen, J., Chen, S., Cherubini, A., Concha, L., David, P., Delanty, N., Depondt, C., Devinsky, O., Doherty, C.P., Domin, M., Focke, N.K., Foley, S., Franca, W., Gambardella, A., Guerrini, R., Hamandi, K., Hibar, D.P., Isaev, D., Jackson, G.D., Jahanshad, N., Kälviäinen, R., Keller, S.S., Kochunov, P., Kotikalapudi, R., Kowalczyk, M.A., Kuzniecky, R., Kwan, P., Labate, A., Langner, S., Lenge, M., Liu, M., Martin, P., Mascalchi, M., Meletti, S., Morita-Sherman, M.E., O'Brien, T.J., Pariente, J.C., Richardson, M.P., Rodriguez-Cruces, R., Rummel, C., Saavalainen, T., Semmelroch, M.K., Severino, M., Striano, P., Thesen, T., Thomas, R.H., Tondelli, M., Tortora, D., Vaudano, A.E., Vivash, L., von Podewils, F., Wagner, J., Weber, B., Wiest, R., Yasuda, C.L., Zhang, G., Zhang, J., Leu, C., Avbersek, A., Thom, M., Whelan, C.D., Thompson, P., McDonald, C.R., Vezzani, A., Sisodiya, S.M., A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies, Neuropathology and Applied Neurobiology, 48, (1), 2022
Byrne, B., O"Carroll, R.F., Doherty, C., Sturge-Weber syndrome: Case report, literature review and proposed pregnancy care plan, Obstetric Medicine, 15, (4), 2022, p276-279
Greene, C. and Hanley, N. and Reschke, C.R. and Reddy, A. and MÀe, M.A. and Connolly, R. and Behan, C. and Oâ Keeffe, E. and Bolger, I. and Hudson, N. and Delaney, C. and Farrell, M.A. and Oâ Brien, D.F. and Cryan, J. and Brett, F.M. and Beausang, A. and Betsholtz, C. and Henshall, D.C. and Doherty, C.P. and Campbell, M., Microvascular stabilization via blood-brain barrier regulation prevents seizure activity, Nature Communications, 13, (1), 2022
Campbell, C., McCormack, M., Patel, S., Stapleton, C., Bobbili, D., Krause, R., Depondt, C., Sills, G.J., Koeleman, B.P., Striano, P., Zara, F., Sander, J., Lerche, H., Kunz, W.S., Stefansson, K., Stefansson, H., Doherty, C.P., Heinzen, E.L., Scheffer, I.E., Goldstein, D., O'Brien, T., Cotter, D., Berkovic, S.F., Sisodiya, S.M., Delanty, N., Cavalleri, G.L., A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam, Epilepsia, 63, (6), 2022, p1563-1570
Larivière, S., Royer, J., Rodríguez-Cruces, R., Paquola, C., Caligiuri, M.E., Gambardella, A., Concha, L., Keller, S.S., Cendes, F., Yasuda, C.L., Bonilha, L., Gleichgerrcht, E., Focke, N.K., Domin, M., von Podewills, F., Langner, S., Rummel, C., Wiest, R., Martin, P., Kotikalapudi, R., O"Brien, T.J., Sinclair, B., Vivash, L., Desmond, P.M., Lui, E., Vaudano, A.E., Meletti, S., Tondelli, M., Alhusaini, S., Doherty, C.P., Cavalleri, G.L., Delanty, N., Kälviäinen, R., Jackson, G.D., Kowalczyk, M., Mascalchi, M., Semmelroch, M., Thomas, R.H., Soltanian-Zadeh, H., Davoodi-Bojd, E., Zhang, J., Winston, G.P., Griffin, A., Singh, A., Tiwari, V.K., Kreilkamp, B.A.K., Lenge, M., Guerrini, R., Hamandi, K., Foley, S., Rüber, T., Weber, B., Depondt, C., Absil, J., Carr, S.J.A., Abela, E., Richardson, M.P., Devinsky, O., Severino, M., Striano, P., Tortora, D., Kaestner, E., Hatton, S.N., Vos, S.B., Caciagli, L., Duncan, J.S., Whelan, C.D., Thompson, P.M., Sisodiya, S.M., Bernasconi, A., Labate, A., McDonald, C.R., Bernasconi, N., Bernhardt, B.C., Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression, Nature Communications, 13, (1), 2022
Sisodiya, S.M., Whelan, C.D., Hatton, S.N., Huynh, K., Altmann, A., Ryten, M., Vezzani, A., Caligiuri, M.E., Labate, A., Gambardella, A., Ives-Deliperi, V., Meletti, S., Munsell, B.C., Bonilha, L., Tondelli, M., Rebsamen, M., Rummel, C., Vaudano, A.E., Wiest, R., Balachandra, A.R., Bargalló, N., Bartolini, E., Bernasconi, A., Bernasconi, N., Bernhardt, B., Caldairou, B., Carr, S.J.A., Cavalleri, G.L., Cendes, F., Concha, L., Desmond, P.M., Domin, M., Duncan, J.S., Focke, N.K., Guerrini, R., Hamandi, K., Jackson, G.D., Jahanshad, N., Kälviäinen, R., Keller, S.S., Kochunov, P., Kowalczyk, M.A., Kreilkamp, B.A.K., Kwan, P., Lariviere, S., Lenge, M., Lopez, S.M., Martin, P., Mascalchi, M., Moreira, J.C.V., Morita-Sherman, M.E., Pardoe, H.R., Pariente, J.C., Raviteja, K., Rocha, C.S., Rodríguez-Cruces, R., Seeck, M., Semmelroch, M.K.H.G., Sinclair, B., Soltanian-Zadeh, H., Stein, D.J., Striano, P., Taylor, P.N., Thomas, R.H., Thomopoulos, S.I., Velakoulis, D., Vivash, L., Weber, B., Yasuda, C.L., Zhang, J., Thompson, P.M., McDonald, C.R., Abela, E., Absil, J., Adams, S., Alhusaini, S., Alvim, M., Balestrini, S., Bender, B., Bergo, F., Bernardes, T., Calvo, A., Carreno, M., Cherubini, A., David, P., Davoodi-Bojd, E., Delanty, N., Depondt, C., Devinsky, O., Doherty, C., França, W.C., Franceschet, L., Hibar, D.P., Ishikawa, A., Kaestner, E., Langner, S., Liu, M., Mirandola, L., Naylor, J., Nazem-Zadeh, M.-R., O'Brien, T.J., Ribeiro, L.F., Richardson, M., Rosenow, F., Severino, M., Shuai, C., Tortora, D., von Podewils, F., Vos, S.B., Wagner, J., Zhang, G., The ENIGMA-Epilepsy working group: Mapping disease from large data sets, Human Brain Mapping, 43, (1), 2022, p113-128
Banks, J., Doherty, C.P., CoVID Tracker Ireland: What is its Function?, Irish Medical Journal, 115, (1), 2022
Greene, C., Connolly, R., Brennan, D., Laffan, A., O'Keeffe, E., Zaporojan, L., Connolly, E., Cheallaigh, C.N., Conlon, N., Doherty, C., Campbell, M., Blood-brain barrier disruption in Long COVID-associated cognitive impairment, ResearchSquare, 2022
Doherty C, Nowacki AS, McAndrews MP, McDonald CR, Reyes A, Kim MS, Hamberger M, Najm I, Bingaman W, Jehi L, Busch RM, Response: Predicting mood decline following temporal lobe epilepsy surgery in adults., Epilepsia, 2021
Harford, D.A. and Delaney, C. and O'Callaghan, J. and Hudson, N. and Connolly, R. and Doyle, S. and Farrell, M. and Doherty, C.P. and Cahill, M. and Campbell, M., Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo- Drusen?, Ophthalmic Surgery Lasers and Imaging Retina, 52, (12), 2021, p666-671
Scarboro CG, Ruzsa SM, Doherty CJ, Kudenov MW, Quantification of gray mold infection in lettuce using a bispectral imaging system under laboratory conditions., Plant direct, 2021
Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A., Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction, Brain, 2021
COVIDSurg Collaborative, GlobalSurg Collaborative , SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study., The British journal of surgery, 2021
Fitzsimons, M., Power, K., McCrea, Z., Kiersey, R., White, M., Dunleavy, B., O'Donoghue, S., Lambert, V., Delanty, N., Doherty, C.P., Democratizing epilepsy care: Utility and usability of an electronic patient portal, Epilepsy and Behavior, 122, 2021
Linehan, C., Benson, A., Gunko, A., Christensen, J., Sun, Y., Tomson, T., Marson, A., Forsgren, L., Trinka, E., Iliescu, C., Althoehn Sonderup, J., Werenberg Dreier, J., Sandu, C., Leanca, M., Rainer, L., Kobulashvili, T., Granbichler, C.A., Delanty, N., Doherty, C., Staines, A., Shahwan, A., Baker, G., Bolger, E., Jennum, P.J., Ilescu, C., Malmgren, K., Marson, A., Kjellberg, J., Kerr, M., Covanis, A., Sales, F., Mameniskiene, R., Ekman, M., Ryvlin, P., Holmgaard, M.N., Granbichler, C., Exploring the prevalence and profile of epilepsy across Europe using a standard retrospective chart review: Challenges and opportunities, Epilepsia, 62, (11), 2021, p2651-2666
Delaney, C. and Farrell, M. and Doherty, C.P. and Brennan, K. and Oâ Keeffe, E. and Greene, C. and Byrne, K. and Kelly, E. and Birmingham, N. and Hickey, P. and Cronin, S. and Savvides, S.N. and Doyle, S.L. and Campbell, M., Attenuated CSF-1R signalling drives cerebrovascular pathology, EMBO Molecular Medicine, 13, (2), 2021
Quinn N, García-Gutiérrez L, Doherty C, von Kriegsheim A, Fallahi E, Matallanas D, IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway, 2021
McGillivray MK, Haldane C, Doherty C, Berger MJ, Evaluation of muscle strength following peripheral nerve surgery: a scoping review., PM & R : the journal of injury, function, and rehabilitation, 2021
Doran E, Barron E, Healy L, O'Connor L, Synnott C, Ni Cheallaig, Doherty C, Improving access to epilepsy care for homeless patients in the Dublin Inner City: a collaborative quality improvement project joining hospital and community care, British Jorurnal of Medicine Open Quality, 2021, pe001367-
Doherty C, Quinn N, Mistry S, Diacono J, Walker R, Harrison A, Bateman N, Bruce I, LID Study: Plasma lidocaine levels following airway topicalisation for paediatric microlaryngobronchoscopy (MLB), 2021
Osborne D, Doherty C, Blame the pandemic: Why you need to raise your fees for 2021., The Canadian veterinary journal = La revue veterinaire canadienne, 2021
Doherty CA, Diegmiller R, Kapasiawala M, Gavis ER, Shvartsman SY, Coupled oscillators coordinate collective germline growth., Developmental cell, 2021
Loaiza VM, Doherty C, Howlett P, The long-term consequences of retrieval demands during working memory., Memory & cognition, 2021
Büttner F, Howell DR, Doherty C, Blake C, Ryan J, Delahunt E, Clinical Detection and Recovery of Vestibular and Oculomotor Impairments Among Amateur Athletes Following Sport-Related Concussion: A Prospective, Matched-Cohort Study., The Journal of head trauma rehabilitation, 2021
Bheemanahalli R, Knight M, Quinones C, Doherty CJ, Jagadish SVK, Genome-wide association study and gene network analyses reveal potential candidate genes for high night temperature tolerance in rice., Scientific reports, 2021
Doran, E.M., Stanila, R.M., Healy, L.A., Hynes, S.F., Doherty, C.P., Computed tomography and emergency department frequency in homeless patients with seizures, Seizure, 91, 2021, p72-74
McKenna MC, Al-Hinai M, Bradley D, Doran E, Hunt I, Hutchinson S, Langan Y, O'Rourke D, Qasem R, Redmond J, Troy E, Doherty CP., Patients' Experiences of Remote Neurology Consultations during the COVID-19 Pandemic, European Neurology, 83, (6), 2021, p622 - 625
Gleichgerrcht, E., Munsell, B.C., Alhusaini, S., Alvim, M.K.M., Bargalló, N., Bender, B., Bernasconi, A., Bernasconi, N., Bernhardt, B., Blackmon, K., Caligiuri, M.E., Cendes, F., Concha, L., Desmond, P.M., Devinsky, O., Doherty, C.P., Domin, M., Duncan, J.S., Focke, N.K., Gambardella, A., Gong, B., Guerrini, R., Hatton, S.N., Kälviäinen, R., Keller, S.S., Kochunov, P., Kotikalapudi, R., Kreilkamp, B.A.K., Labate, A., Langner, S., Larivière, S., Lenge, M., Lui, E., Martin, P., Mascalchi, M., Meletti, S., O'Brien, T.J., Pardoe, H.R., Pariente, J.C., Xian Rao, J., Richardson, M.P., Rodríguez-Cruces, R., Rüber, T., Sinclair, B., Soltanian-Zadeh, H., Stein, D.J., Striano, P., Taylor, P.N., Thomas, R.H., Elisabetta Vaudano, A., Vivash, L., von Podewills, F., Vos, S.B., Weber, B., Yao, Y., Lin Yasuda, C., Zhang, J., Thompson, P.M., Sisodiya, S.M., McDonald, C.R., Bonilha, L., Altmann, A., Depondt, C., Galovic, M., Thomopoulos, S.I., Wiest, R., Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study, NeuroImage: Clinical, 31, 2021
Gale C, Quigley MA, Placzek A, Knight M, Ladhani S, Draper ES, Sharkey D, Doherty C, Mactier H, Kurinczuk JJ, The ability of the neonatal immune response to handle SARS-CoV-2 infection - Authors' reply., The Lancet. Child & adolescent health, 2021
Larivière, S., Royer, J., Rodríguez-Cruces, R., Caligiuri, M.E., Gambardella, A., Concha, L., Keller, S.S., Cendes, F., Yasuda, C.L., Bonilha, L., Gleichgerrcht, E., Focke, N.K., Domin, M., von Podewills, F., Langner, S., Rummel, C., Wiest, R., Martin, P., Kotikalapudi, R., O'Brien, T.J., Sinclair, B., Vivash, L., Desmond, P.M., Lui, E., Vaudano, A.E., Meletti, S., Tondelli, M., Alhusaini, S., Doherty, C.P., Cavalleri, G.L., Delanty, N., Kälviäinen, R., Jackson, G.D., Kowalczyk, M., Mascalchi, M., Semmelroch, M., Thomas, R.H., Soltanian-Zadeh, H., Davoodi-Bojd, E., Zhang, J., Kreilkamp, B.A.K., Lenge, M., Guerrini, R., Hamandi, K., Foley, S., Rüber, T., Weber, B., Depondt, C., Absil, J., Carr, S.J.A., Abela, E., Richardson, M.P., Devinsky, O., Severino, M., Striano, P., Tortora, D., Hatton, S.N., Vos, S.B., Caciagli, L., Duncan, J.S., Whelan, C.D., Thompson, P.M., Sisodiya, S.M., Bernasconi, A., Labate, A., McDonald, C.R., Bernasconi, N., Bernhardt, B.C., Structural network alterations in focal and generalized epilepsy follow axes of epilepsy risk gene expression: An ENIGMA study, bioRxiv, 2021
Speaker SL, Doherty CM, Pfoh E, Dunn A, Hair B, Daboul L, Shaker V, Rothberg M, Social Behaviors Associated With a Positive COVID-19 Test Result., Cureus, 2021
Hughes, J.E., Buckley, N., Looney, Y., Kirwan, G., Curran, S., Doherty, C.P., Mullooly, M., Bennett, K.E., Awareness, knowledge and practice of healthcare professionals following implementation of a Pregnancy Prevention Program for sodium valproate in Ireland: a multi-stakeholder cross-sectional study, Expert Opinion on Drug Safety, 20, (8), 2021, p965-977
Doherty C, Nowacki AS, Pat McAndrews M, McDonald CR, Reyes A, Kim MS, Hamberger M, Najm I, Bingaman W, Jehi L, Busch RM, Predicting mood decline following temporal lobe epilepsy surgery in adults., Epilepsia, 2021
Mizrahi Rodriguez K, Lin S, Wu AX, Han G, Teesdale JJ, Doherty CM, Smith ZP, Leveraging Free Volume Manipulation to Improve the Membrane Separation Performance of Amine-Functionalized PIM-1., Angewandte Chemie (International ed. in English), 2021
Büttner F, Howell DR, Iverson GL, Doherty C, Blake C, Ryan J, Delahunt E, Participation in pre-injury level sport one-year following sport-related concussion: A prospective, matched cohort study., Journal of science and medicine in sport, 2021
Cervenka, M.C., Wood, S., Bagary, M., Balabanov, A., Bercovici, E., Brown, M.-G., Devinsky, O., Di Lorenzo, C., Doherty, C.P., Felton, E., Healy, L.A., Klein, P., Kverneland, M., Lambrechts, D., Langer, J., Nathan, J., Munn, J., Nguyen, P., Phillips, M., Roehl, K., Tanner, A., Williams, C., Zupec-Kania, B., International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies, Neurology: Clinical Practice, 11, (5), 2021, p385-397
Quinn NP, García-Gutiérrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks DB, Matallanas D, IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway., Cells, 2021
Jacquemard T, Doherty CP, Fitzsimons MB, The anatomy of electronic patient record ethics: a framework to guide design, development, implementation, and use., BMC medical ethics, 2021
Büttner F, Howell DR, Doherty C, Blake C, Ryan J, Delahunt E, Longitudinal Vestibular and Oculomotor Impairments Among Amateur Athletes 1 Year Following Sport-Related Concussion: A Prospective Follow-Up., The Journal of head trauma rehabilitation, 2021
Jack Banks, Derek Corrigan, Roger Grogan, Hany El-Naggar, Máire White, Elisabeth Doran, Cara Synnott, Mary Fitzsimons, Norman Delanty, Colin P. Doherty, LoVE in a time of CoVID: Clinician and patient experience using telemedicine for chronic epilepsy management. Epilepsy and Behaviour, Epilepsy and behaviour, 2020
McCrea Z, Power K, Kiersey R, White M, Breen A, Murphy S, Healy L, Kearney H, Dunleavy B, O'Donoghue S, Lambert V, Delanty N, Doherty C, Fitzsimons M, Coproducing health and well-being in partnership with patients, families, and healthcare providers: A qualitative study exploring the role of an epilepsy patient portal., Epilepsy & behavior : E&B, 2020
Power K, McCrea Z, White M, Breen A, Dunleavy B, O'Donoghue S, Jacquemard T, Lambert V, El-Naggar H, Delanty N, Doherty C, Fitzsimons M, The development of an epilepsy electronic patient portal: Facilitating both patient empowerment and remote clinician-patient interaction in a post-COVID-19 world., Epilepsia, 2020
Jacquemard T, Doherty CP, Fitzsimons MB, Examination and diagnosis of electronic patient records and their associated ethics: a scoping literature review., BMC medical ethics, 2020
Gardner RC, Rivera E, O'Grady M, Doherty C, Yaffe K, Corrigan J, Bogner J, Kramer J, Wilson F, Screening for lifetime history of traumatic brain injury among American and Irish adults ar risk for dementia: Development and validation of a web-based survey, Journal of Alzheimer's Disease, 2020
Elashkar AH, Parasar D, Muñoz-Castro A, Doherty CM, Cowan MG, Dias HVR, Isolable 1-Butene Copper(I) Complexes and 1-Butene/Butane Separation Using Structurally Adaptable Copper Pyrazolates., ChemPlusChem, 2020
Tiernan S, Meagher A, O'Sullivan D, O'Keeffe E, Kelly E, Wallace E, Doherty CP, Campbell M, Liu Y, Domel AG, Concussion and the severity of head impacts in mixed martial arts., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 234, 2020, 1472 - 1483
O'Keeffe, E. and Kelly, E. and Liu, Y. and Giordano, C. and Wallace, E. and Hynes, M. and Tiernan, S. and Meagher, A. and Greene, C. and Hughes, S. and Burke, T. and Kealy, J. and Doyle, N. and Hay, A. and Farrell, M. and Grant, G.A. and Friedman, A. and Veksler, R. and Molloy, M.G. and Meaney, J.F. and Pender, N. and Camarillo, D. and Doherty, C.P. and Campbell, M., Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury, Journal of neurotrauma, 37, (2), 2020, p347-356
Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, dummy-AUTHOR_name, Seshadri S, Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults., Nature communications, 2020
Hatton SN, Huynh KH, Bonilha L, Abela E, Alhusaini S, Altmann A, Alvim MKM, Balachandra AR, Bartolini E, Bender B, Bernasconi N, Bernasconi A, dummy-AUTHOR_name, McDonald CR, White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study., Brain : a journal of neurology, 2020
O'Gorman, P., Strahan, O., Ferguson, D., Monaghan, A., Kennedy, M., Forde, C., Melo, A., Doherty, D., O'Brien, K., McKiernan, S., Kenny, R., Coen, R.F., Doherty, C., Bergin, C., Gormley, J., Norris, S. , Improvement in cognitive impairment following a 12-week aerobic exercise intervention in individuals with non-cirrhotic chronic hepatitis C., Journal of Viral Hepatitis , 2020
Benson KA, White M, Allen NM, Byrne S, Carton R, Comerford E, Costello D, Doherty C, Dunleavey B, El-Naggar H, Gangadharan N, Heavin S, Kearney H, Cavalleri GL, A comparison of genomic diagnostics in adults and children with epilepsy and comorbid intellectual disability., European journal of human genetics : EJHG, 2020
Steinhoff BJ, Christensen J, Doherty CP, Majoie M, De Backer M, Hellot S, Leunikava I, Leach JP, Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: Second interim analysis of 6-month data from a prospective observational study in Europe., Epilepsy research, 2020
Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, dummy-AUTHOR_name, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)"Genetics working group, The genetic architecture of the human cerebral cortex., Science (New York, N.Y.), 2020
Banks J, Corrigan D, Grogan R, El-Naggar H, White M, Doran E, Synnott C, Fitzsimons M, Delanty N, Doherty CP, LoVE in a time of CoVID: Clinician and patient experience using telemedicine for chronic epilepsy management., Epilepsy & behavior : E&B, 2020
Kelleher E, McNamara P, Dunne J, Fitzmaurice B, Heron EA, Whitty P, Walsh R, Mooney C, Hogan D, Conlon N, Gill M, Vincent A, Doherty CP, Corvin A., Prevalence of N-Methyl-d-Aspartate Receptor antibody (NMDAR-Ab) encephalitis in patients with first episode psychosis and treatment resistant schizophrenia on clozapine, a population based study., Schizophrenia research, 222, 2020, p455-461
Banks J, Varley J, Fitzsimons M, Doherty CP, Self-reported antiepilepsy medication adherence and its connection to perception of medication error., Epilepsy & behavior : E&B, 2020
Laksari K, Fanton M, Wu LC, Nguyen TH, Kurt M, Giordano C, Kelly E, O'Keeffe E, Wallace E, Doherty C, Campbell M, Tiernan S, Grant G, Ruan J, dummy-AUTHOR_name, Camarillo DB, Multi-Directional Dynamic Model for Traumatic Brain Injury Detection., Journal of neurotrauma, 2020
Niestroj LM, Perez-Palma E, Howrigan DP, Zhou Y, Cheng F, Saarentaus E, Nürnberg P, Stevelink R, Daly MJ, Palotie A, Lal D, Epi25 Collaborative, Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17"458 subjects., Brain : a journal of neurology, 2020
Kong XZ, ENIGMA Laterality Working Group, Francks C, Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research., Human brain mapping, 2020
Doherty C, Joorabchi A, Megyesi P, Flynn A, Caulfield B, Physiotherapists' Use of Web-Based Information Resources to Fulfill Their Information Needs During a Theoretical Examination: Randomized Crossover Trial., Journal of medical Internet research, 2020
Larivière S, Rodríguez-Cruces R, Royer J, Caligiuri ME, Gambardella A, Concha L, Keller SS, Cendes F, Yasuda C, Bonilha L, Gleichgerrcht E, Focke NK, dummy-AUTHOR_name, Bernhardt BC, Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study., Science advances, 2020
Varley J, Kiersey R, Power R, Byrne JP, Doherty C, Saris J, Lambert V, Fitzsimons M, Igniting intersectoral collaboration in chronic disease management: a participatory action research study on epilepsy care in Ireland., Journal of interprofessional care, 2019
Power R, Byrne JP, Kiersey R, Varley J, Doherty CP, Lambert V, Heffernan E, Saris AJ, Fitzsimons M, Are patients ready for integrated person-centered care? A qualitative study of people with epilepsy in Ireland., Epilepsy & behavior : E&B, 2019
Epi25 Collaborative. Electronic address: s.berkovic@unimelb.edu.au, Epi25 Collaborative, Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals., American journal of human genetics, 2019
Heavin SB, McCormack M, Wolking S, Slattery L, Walley N, Avbersek A, Novy J, Sinha SR, Radtke R, Doherty C, Auce P, Craig J, Johnson MR, dummy-AUTHOR_name, Delanty N, Genomic and clinical predictors of lacosamide response in refractory epilepsies., Epilepsia open, 2019
Doherty C.P, Rheims S, Assenza G, Boero G, Chaves J, McMurray R, Villanueva V, Eslicarbazepine acetate in epilepsy patients with psychiatric comorbidities and intellectual disability: Clinical practice findings from the Euro-Esli study, Journal of the Neurological Sciences, 402, 2019, p88 - 99
Graham M, Wallace E, Doherty C, McCann A, Naci L, From Awareness to Prognosis: Ethical Implications of Uncovering Hidden Awareness in Behaviorally Nonresponsive Patients., Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees, 2019
Delaney S, O'Connor G, Reardon W, Murphy SJX, Tierney S, Ryan BM, Delaney H, Doherty CP, Guiney M, Brennan P, Tobin WO, McCabe DJH., Extracranial and Intracranial Vasculopathy With "Moyamoya Phenomenon" in Association With Alagille Syndrome., Frontiers in neurology, 9, 2019, p1194
Delanty N, White M, Benson K, McCormack M, Heavin S, Comerford E, Gangadharan N, Power K, Dunleavey B, El-Naggar H, Doherty C, Greally M, dummy-AUTHOR_name, Fitzsimons M, Development of a genomics module within an epilepsy-specific electronic health record: Toward genomic medicine in epilepsy care., Epilepsia, 2019
Alhusaini S, Kowalczyk M.A, Yasuda C.L, Semmelroch M.K, Katsurayama M, Zabin M, Zanão T, Nogueira M.H, Alvim M.K.M, Ferraz V.R, Tsai M.-H, Fitzsimons M, Lopes-Cendes I, Doherty C.P, Cavalleri G.L, Cendes F, Jackson G.D, Delanty N, Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients, Neurology, 92, (4), 2019, pE351 - E358
Doherty, C.P., O'Keeffe. E., Keaney, J., Lawlor, B.A., Coen, R.F., Farrell, M., Campbell, M., Neuropolypathology as a result of severe traumatic brain injury? , Clinical Neuropathology, 38, (1), 2019, p14 - 22
Byrne JP, Power R, Kiersey R, Varley J, Doherty CP, Saris AJ, Heffernan E, Lambert V, Fitzsimons M, Corrigendum to "The rhetoric and reality of integrated patient-centered care for healthcare providers: An ethnographic exploration of epilepsy care in Ireland" [Epilepsy & Behavior (2019) 87-92]., Epilepsy & behavior : E&B, 2019
Higgins A, Downes C, Varley J, Doherty C, Begley C, Elliott N, Supporting and empowering people with epilepsy: Contribution of the Epilepsy Specialist Nurses (SENsE study), Seizure: European Journal of Epilepsy, 71, 2019, p42 - 49
Byrne J.-P, Power R, Kiersey R, Varley J, Doherty C.P, Saris A.J, Lambert V, Fitzsimons M, The rhetoric and reality of integrated patient-centered care for healthcare providers: An ethnographic exploration of epilepsy care in Ireland, Epilepsy and Behavior, 94, 2019, p87 - 92
Agnes Higgins, Carmel Downes, Jarleth Varley, Colin P. Doherty, Cecily Begley, Naomi Elliott, Evidence‐based practice among epilepsy specialist nurses in the Republic of Ireland: Findings from the SENsE study, Journal of Nursing Management, 27, 2019, p840 - 847
Crotty GF, Doherty C, Solomon IH, Berry JD, Samuels MA, Learning from history: Lord Brain and Hashimoto's encephalopathy., Practical neurology, 2019
Stevelink R, Pangilinan F, Jansen FE, Braun KPJ, International League Against Epilepsy Consortium on Complex Epilepsies, Molloy AM, Brody LC, Koeleman BPC., Assessing the genetic association between vitamin B6 metabolism and genetic generalized epilepsy., Molecular genetics and metabolism reports, 21, 2019, p100518
Silvennoinen K, de Lange N, Zagaglia S, Balestrini S, Androsova G, Wassenaar M, Auce P, Avbersek A, Becker F, Berghuis B, Campbell E, Coppola A, dummy-AUTHOR_name, EpiPGX Consortium, Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy., Epilepsia open, 2019
Leu, C., Stevelink, R., Smith, A.W., Goleva, S.B., Kanai, M., Ferguson, L., Campbell, C., Kamatani, Y., Okada, Y., Sisodiya, S.M., Cavalleri, G.L., Koeleman, B.P.C., Lerche, H., Jehi, L., Davis, L.K., Najm, I.M., Palotie, A., Daly, M.J., Busch, R.M., Lal, D., Feng, Y.-C.A., Howrigan, D.P., Abbott, L.E., Tashman, K., Cerrato, F., Churchhouse, C., Gupta, N., Neale, B.M., Berkovic, S.F., Goldstein, D.B., Lowenstein, D.H., Cossette, P., Cotsapas, C., De Jonghe, P., Dixon-Salazar, T., Guerrini, R., Hakonarson, H., Heinzen, E.L., Helbig, I., Kwan, P., Marson, A.G., Petrovski, S., Kamalakaran, S., Stewart, R., Weckhuysen, S., Depondt, C., Dlugos, D.J., Scheffer, I.E., Striano, P., Freyer, C., Krause, R., May, P., McKenna, K., Regan, B.M., Bellows, S.T., Bennett, C.A., Johns, E.M.C., Macdonald, A., Shilling, H., Burgess, R., Weckhuysen, D., Bahlo, M., O'Brien, T.J., Todaro, M., Stamberger, H., Andrade, D.M., Sadoway, T.R., Mo, K., Krestel, H., Gallati, S., Papacostas, S.S., Kousiappa, I., Tanteles, G.A., Šterbová, K., Vlcková, M., Sedlácková, L., Laššuthová, P., Klein, K.M., Rosenow, F., Reif, P.S., Knake, S., Kunz, W.S., Zsurka, G., Elger, C.E., Bauer, J., Rademacher, M., Pendziwiat, M., Muhle, H., Rademacher, A., Van Baalen, A., Von Spiczak, S., Stephani, U., Afawi, Z., Korczyn, A.D., Kanaan, M., Canavati, C., Kurlemann, G., Müller-Schlüter, K., Kluger, G., Häusler, M., Blatt, I., Lemke, J.R., Krey, I., Weber, Y.G., Wolking, S., Becker, F., Hengsbach, C., Rau, S., Maisch, A.F., Steinhoff, B.J., Schulze-Bonhage, A., Schubert-Bast, S., Schreiber, H., Borggräfe, I., Schankin, C.J., Mayer, T., Korinthenberg, R., Brockmann, K., Dennig, D., Madeleyn, R., Kälviäinen, R., Auvinen, P., Saarela, A., Linnankivi, T., Lehesjoki, A.-E., Rees, M.I., Chung, S.-K., Pickrell, W.O., Powell, R., Schneider, N., Balestrini, S., Zagaglia, S., Braatz, V., Johnson, M.R., Auce, P., Sills, G.J., Baum, L.W., Sham, P.C., Cherny, S.S., Lui, C.H.T., Barišic, N., Delanty, N., Doherty, C.P., Shukralla, A., McCormack, M., El-Naggar, H., Canafoglia, L., Franceschetti, S., Castellotti, B., Granata, T., Zara, F., Iacomino, M., Madia, F., Vari, M.S., Mancardi, M.M., Salpietro, V., Bisulli, F., Tinuper, P., Licchetta, L., Pippucci, T., Stipa, C., Muccioli, L., Minardi, R., Gambardella, A., Labate, A., Annesi, G., Manna, L., Gagliardi, M., Parrini, E., Mei, D., Vetro, A., Bianchini, C., Montomoli, M., Doccini, V., Marini, C., Suzuki, T., Inoue, Y., Yamakawa, K., Birute, T., Ruta, M., Algirdas, U., Ruta, P., Jurgita, G., Ruta, S., Sadleir, L.G., King, C., Mountier, E., Caglayan, S.H., Arslan, M., Yapici, Z., Yis, U., Topaloglu, P., Kara, B., Turkdogan, D., Gundogdu-Eken, A., Bebek, N., Ugur-Iseri, S., Baykan, B., Salman, B., Haryanyan, G., Yücesan, E., Kesim, Y., Özkara, Ç., Sheidley, B.R., Shain, C., Poduri, A., Buono, R.J., Ferraro, T.N., Sperling, M.R., Lo, W., Privitera, M., French, J.A., Schachter, S., Kuzniecky, R.I., Devinsky, O., Hegde, M., Khankhanian, P., Helbig, K.L., Ellis, C.A., Spalletta, G., Piras, F., Piras, F., Gili, T., Ciullo, V., Polygenic burden in focal and generalized epilepsies, Brain, 142, (11), 2019, p3473-3481
Zaporojan, L. and McNamara, P.H. and Williams, J.A. and Bergin, C. and Redmond, J. and Doherty, C.P., Seizures in HIV: The case for special consideration, Epilepsy and Behavior Case Reports, 10, 2018, p38-43
Graham, M., Doherty, C., & Naci, L, Using neuroimaging to detect covert awareness and determine prognosis of comatose patients: informing surrogate decision-makers of individual patient results., Seminars in Neurology, 38, (5), 2018, p555-560
Higgins, A., Downes, C., Varley, J., Tyrell, E., Normand, C., Doherty, C., Begley, C. & Elliott, N, Patients with epilepsy care experiences: Comparison between services with and without an epilepsy specialist nurse., Epilepsy & Behavior, 85, 2018, p85 - 94
Kong, X.-Z., Mathias, S.R., Guadalupe, T., (...), Hedberg, M., Orhan, F. , Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium, Proceedings of the National Academy of Sciences of the United States of America, 115, (22), 2018, pE5154-E5163
Altmann, A., Ryten, M., Nunzio, M.D., Ravizza, T., Tolomeo, D., Reynolds, R.H., Somani, A., Bacigaluppi, M., Iori, V., Micotti, E., Botía, J.A., Absil, J., Alhusaini, S., Alvim, M.K.M., Auvinen, P., Bargallo, N., Bartolini, E., Bender, B., Bergo, F.P.G., Bernardes, T., Bernasconi, A., Bernasconi, N., Bernhardt, B.C., Blackmon, K., Braga, B., Caligiuri, M.E., Calvo, A., Carlson, C., Carr, S.J., Cavalleri, G.L., Cendes, F., Chen, J., Chen, S., Cherubini, A., Concha, L., David, P., Delanty, N., Depondt, C., Devinsky, O., Doherty, C.P., Domin, M., Focke, N.K., Foley, S., Franca, W., Gambardella, A., Guerrini, R., Hamandi, K., Hibar, D.P., Isaev, D., Jackson, G.D., Jahanshad, N., Kalviainen, R., Keller, S.S., Kochunov, P., Kotikalapudi, R., Kowalczyk, M.A., Kuzniecky, R., Kwan, P., Labate, A., Langner, S., Lenge, M., Liu, M., Martin, P., Mascalchi, M., Meletti, S., Morita, M.E., O'Brien, T.J., Pariente, J.C., Richardson, M.P., Rodriguez-Cruces, R., Rummel, C., Saavalainen, T., Semmelroch, M.K., Severino, M., Striano, P., Thesen, T., Thomas, R.H., Tondelli, M., Tortora, D., Vaudano, A.E., Vivash, L., von Podewils, F., Wagner, J., Weber, B., Wiest, R., Yasuda, C.L., Zhang, G., Zhang, J., Leu, C., Avbersek, A., Thom, M., Whelan, C.D., Thompson, P., McDonald, C., Vezzani, A., Sisodiya, S.M., A systems-level analysis highlights microglial activation as a modifying factor in common forms of human epilepsy, bioRxiv, 2018
Whelan, C.D. and Altmann, A. and BotÃa, J.A. and Jahanshad, N. and Hibar, D.P. and Absil, J. and Alhusaini, S. and Alvim, M.K.M. and Auvinen, P. and Bartolini, E. and Bergo, F.P.G. and Bernardes, T. and Blackmon, K. and Braga, B. and Caligiuri, M.E. and Calvo, A. and Carr, S.J. and Chen, J. and Chen, S. and Cherubini, A. and David, P. and Domin, M. and Foley, S. and França, W. and Haaker, G. and Isaev, D. and Keller, S.S. and Kotikalapudi, R. and Kowalczyk, M.A. and Kuzniecky, R. and Langner, S. and Lenge, M. and Leyden, K.M. and Liu, M. and Loi, R.Q. and Martin, P. and Mascalchi, M. and Morita, M.E. and Pariente, J.C. and RodrÃguez-Cruces, R. and Rummel, C. and Saavalainen, T. and Semmelroch, M.K. and Severino, M. and Thomas, R.H. and Tondelli, M. and Tortora, D. and Vaudano, A.E. and Vivash, L. and Von Podewils, F. and Wagner, J. and Weber, B. and Yao, Y. and Yasuda, C.L. and Zhang, G. and Bargalló, N. and Bender, B. and Bernasconi, N. and Bernasconi, A. and Bernhardt, B.C. and BlÃŒmcke, I. and Carlson, C. and Cavalleri, G.L. and Cendes, F. and Concha, L. and Delanty, N. and Depondt, C. and Devinsky, O. and Doherty, C.P. and Focke, N.K. and Gambardella, A. and Guerrini, R. and Hamandi, K. and Jackson, G.D. and KÀlviÀinen, R. and Kochunov, P. and Kwan, P. and Labate, A. and McDonald, C.R. and Meletti, S. and O'Brien, T.J. and Ourselin, S. and Richardson, M.P. and Striano, P. and Thesen, T. and Wiest, R. and Zhang, J. and Vezzani, A. and Ryten, M. and Thompson, P.M. and Sisodiya, S.M., Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study, Brain, 141, (2), 2018, p391-408
Higgins, A., Downes, C., Varley, J., Doherty, C. P., Begley, C., & Elliott, N., Rising to the challenge: Epilepsy specialist nurses as leaders of service improvements and change (SENsE study)., Seizure: European Journal of Epilepsy, 63, 2018, p40 - 47
International League Against Epilepsy Consortium on Complex Epilepsies., Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies., Nature communications, 9, (1), 2018, p5269
Williams, J. and Doherty, J. and Di Blasi, C. and Mabarak, D. and Kennedy, U. and Doherty, C.P., Seizure care in the emergency department. Identifying and bridging the gaps. A study of care and outcomes from 644 seizure presentations, Epilepsy and Behavior, 78, 2018, p226-231
Williams, J. and Petrov, G. and Kennedy, U. and Halpenny, J. and Doherty, C.P., Moving evidence based guidelines for seizures into practice in the emergency department: What's stopping us?, Epilepsy and Behavior, 72, 2017, p72-77
McDermott A, Zaporojan L, McNamara P, Doherty C.P, Redmond J, Forde C, Gormley J, Egaña M, Bergin C, The effects of a 16-week aerobic exercise programme on cognitive function in people living with HIV, AIDS Care , 29, (6), 2017, p. 667-674
Jennifer Williams, Gerard Mullins, Norman Delanty, Peter Bede, Colin Doherty , The spectrum of peri-ictal MRI changes; four Illustrative cases., Seizure: European Journal of Epilepsy , 50, 2017, p189-193
McNamara, P.H. and Coen, R. and Redmond, J. and Doherty, C.P. and Bergin, C., A high prevalence rate of a positive screen for cognitive impairment in patients with human immunodeficiency virus attending an Irish clinic, Open Forum Infectious Diseases, 4, (1), 2017, p1-9
Williams JA, Bede P, Doherty CP, An exploration of the spectrum of peri-ictal MRI change; a comprehensive literature review., Seizure, 50, 2017, p19-32
Lynn E, Lyons S, Langan Y, Craig S, Doherty C, The role of alcohol dependency in deaths among people with epilepsy recorded by the National Drug-Related Deaths Index (NDRDI) in Ireland, 2004-2013, Seizure, 45, 2017, p52 - 55
Kinsella JA, Oliver Tobin W, Tierney S, Feeley TM, Egan B, Coughlan T, Ronan Collins D, O'Neill D, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJH, Assessment of 'on-treatment platelet reactivity' and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis., J Neurol Sci., 376, 2017, p133 - 139
Androsova, G., Krause, R., Borghei, M., Wassenaar, M., Auce, P., Avbersek, A., Becker, F., Berghuis, B., Campbell, E., Coppola, A., Francis, B., Wolking, S., Cavalleri, G.L., Craig, J., Delanty, N., Koeleman, B.P.C., Kunz, W.S., Lerche, H., Marson, A.G., Sander, J.W., Sills, G.J., Striano, P., Zara, F., Sisodiya, S.M., Depondt, C., Brodie, M.J., Chinthapalli, K., de Haan, G.-J., Doherty, C., Gudmundsson, L.J., Heavin, S., Ingason, A., Johnson, M., Kennedy, C., Krenn, M., McCormack, M., O'Brien, T.J., Pandolfo, M., Pataraia, E., Petrovski, S., Rau, S., Sargsyan, N., Slattery, L., Stefánsson, K., Stern, W., Tostevin, A., Willis, J., Zimprich, F., Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis, Epilepsia, 58, (10), 2017, p1734-1741
Keller C, Arsenault S, Lamothe M, Bostan SR, O'Donnell R, Harbison J, Doherty CP., Patient safety ward round checklist via an electronic app: implications for harm prevention., Ir J Med Sci, 2017
Haque, A. and Doherty, C. and Williams, J., Non-attendance of vulnerable populations within epilepsy outpatient services in Ireland, Irish Journal of Medical Science, 2017, p1-4
Doherty C.P, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries M.M, Molloy M.G, Meaney J.F, Farrell M, Campbell M, Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy, Journal of Neuropathology and Experimental Neurology, 75, (7), 2016, p656 - 662
Alhusaini S, Whelan C.D, Doherty C.P, Delanty N, Fitzsimons M, Cavalleri G.L, Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings, Cerebral Cortex, 26, (3), 2016, p1234 - 1241
Murphy S, Bennett K, Doherty C.P, Prescribing trends for sodium valproate in Ireland, Seizure, 36, 2016, p44 - 48
Doherty CP, Hardiman O., Handboook of Neurodegeneration, 1&2, UK, Springer Verlag, 2016
Kenny RA, Brignole M, Dan GA, Deharo JC, van Dijk JG, Doherty C, Hamdan M, Moya A, Parry SW, Sutton R, Ungar A, Wieling W; External contributors to the Task Force:, Asgari M, Baron-Esquivias G, Blanc JJ, Casagranda I, Cunnigham C, Fedorowski A, Furlan R, Gall N, De Lange FJ, Mcmahon G, Mitro P, Pietrucha A, Podoleanu C, Raviele A, Benditt D, Krahn A, Morillo CA, Olshansky B, Raj S, Sheldon R, Shen WK, Sun B, Hachul D, Abe H, Furukawa T;, Syncope Unit: rationale and requirement - the European Heart Rhythm Association position statement endorsed by the Heart Rhythm Society, Europace, 17, (9), 2015, p1328 - 1340
Bennett, L., Bergin, M., Gooney, M., (...), Synnott, C., Wells, J.S.G., Epilepsy services in Ireland: 'A survey of people with epilepsy in relation to satisfaction, preferences and information provision', Epilepsy Research, 113, 2015, p11-18
Kinsella JA, Tobin WO, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Feeley TM, Egan B, O'Neill D, Collins DR, Coughlan T, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJ, Increased thrombin generation potential in symptomatic versus asymptomatic moderate or severe carotid stenosis and relationship with cerebral microemboli., Journal of Neurology, Neurosurgery, and Psychiatry, 86, 2015, p460-467
Whelan C.D, Alhusaini S, O'Hanlon E, Cheung M, Iyer P.M, Meaney J.F, Fagan A.J, Boyle G, Delanty N, Doherty C.P, Cavalleri G.L, White matter alterations in patients with MRI-negative temporal lobe epilepsy and their asymptomatic siblings, Epilepsia, 56, (10), 2015, p1551 - 1561
International League Against Epilepsy Consortium on Complex Epilepsies, Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies., The Lancet. Neurology, 13, (9), 2014, p893-903
Kinsella JA, Tobin WO, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Feeley TM, Egan B, O'Neill D, Collins RD, Coughlan T, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJ, Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups., European Journal of Neurology, 2014, p460-467
Boronat, S., Shaaya, E.A., Doherty, C.M., Caruso, P., Thiele, E.A., Tuberous sclerosis complex without tubers and subependymal nodules: A phenotype-genotype study, Clinical Genetics, 86, (2), 2014, p149-154
Scanlon, C. Ronan, L. Doherty, C.P. Cavalleri, G.L. Tirupati, S. Alhusaini, S. Maguire, S. Delanty, N. Iyer, P.M. Chaila, E. Fitzsimons, M., MRI-Based Brain Structure Volumes in Temporal Lobe Epilepsy Patients and their Unaffected Siblings: A Preliminary Study, Journal of Neuroimaging, 23, (1), 2013, p64 - 70
Donohue F, Doherty C, Langan Y, White M, Morrow S, White M, Hayes CB , Mortality from SUDEP and Status Epilepticus in Ireland, Irish Medical Journal, 106, (3), 2013, p91 - 92
Mc Cormack O, Cooney JM, Doherty CP, Muldoon C, Reynolds JV, Paraneoplastic limbic encephalitis from esophagogastric squamous cell carcinoma successfully managed by radical gastrectomy., Surgery, 154, (3), 2013, p638-40
Lauhoff, P., Murphy, N., Doherty, C., Horgan, N.F., A controlled clinical trial investigating the effects of cycle ergometry training on exercise tolerance, balance and quality of life in patients with Parkinson's disease., Disability and rehabilitation, 35, (5), 2013, p382-387
Alhusaini, S. Ronan, L. Scanlon, C. Whelan, C.D. Doherty, C.P. Delanty, N. Fitzsimons, M., Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy, Epilepsia, 54, (9), 2013, pe138 - e141
Donohue, F., Doherty, C., Langan, Y., White, M., White, M., Morrow, S., Hayes, C., Mortality due to sudep and status epilepticus, Irish Medical Journal, 106, (3), 2013, p1-2
McNamara PH, Toner M, Kearns G, Keohane C, Daly P, Doherty CP, Focal seizures secondary to cortical dysplasia associated with isolated oral morphea and odontogenic carcinoma., Seizure : the journal of the British Epilepsy Association, 22, (2), 2013, p159-61
, Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A, Brain : a journal of neurology, 2013
Alhusaini S, Scanlon C, Ronan L, Maguire S, Meaney JF, Fagan AJ, Boyle G, Borgulya G, Iyer PM, Brennan P, Costello D, Chaila E, Fitzsimons M, Doherty CP, Delanty N, Cavalleri GL, Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy., PloS one, 8, (4), 2013, pe61880
O'Connor, G. Doherty, C.P., Folic acid: When to supplement and by how much, European Neurological Journal, 4, (2), 2013
Kinsella J, Tobin W, Tierney S, Feeley T, Egan B, Collins D, Coughlan T, O'Neill D, Harbison J, Madhavan P, Moore D, O'Neill S, Colgan M, Doherty C, Murphy R, Saqqur M, Moran N, Hamilton G, McCabe D, Increased platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study., Journal of Thrombosis and Haemostasis : JTH, 11, (7), 2013, p1407-16
Iyer PM, McNamara PH, Fitzgerald M, Smyth L, Dardis C, Jawad T, Plunkett PK, Doherty CP,, A seizure care pathway in the emergency department: preliminary quality and, Epilepsy Research and Treatment, (Epub May 29 2012 ), 2012, p273175
Alhusaini, S. Doherty, C.P. Scanlon, C. Ronan, L. Maguire, S. Borgulya, G. Brennan, P. Delanty, N. Fitzsimons, M. Cavalleri, G.L., A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis, Epilepsy Research, 99, (1-2), 2012, p156 - 166
, A seizure care pathway in the emergency department: preliminary quality and safety improvements, Epilepsy research and treatment, 2012
Campbell M, Hanrahan F, Gobbo OL, Kelly ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW, Kerskens CM, Cahalan SD, Callanan JJ, Wallace E, Grant GA, Doherty CP, Humphries P, Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury., Nature communications, 3, 2012, p849
McNamara, P. Redmond, J. Bergin, C. Doherty, C., The case for cognitive screening in HIV clinics, Irish Medical Journal, 105, (7), 2012
Alhusaini, S. Doherty, C.P. Palaniyappan, L. Scanlon, C. Maguire, S. Brennan, P. Delanty, N. Fitzsimons, M. Cavalleri, G.L., Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis, Epilepsia, 53, (6), 2012, p995 - 1003
Omer TA, Fitzgerald DE, Sheehy N, Doherty CP, Neurosyphilis presenting with unusual hippocampal abnormalities on magnetic resonance imaging and positron emission tomography scans: a case report., Journal of medical case reports, 6, (1), 2012, p389
Ronan, L. Alhusaini, S. Scanlon, C. Doherty, C.P. Delanty, N. Fitzsimons, M., Widespread cortical morphologic changes in juvenile myoclonic epilepsy: Evidence from structural MRI, Epilepsia, 53, (4), 2012, p651 - 658
Coker, M.F. Bhargava, S. Fitzgerald, M. Doherty, C.P., What do people with epilepsy know about their condition? Evaluation of a subspecialty clinic population, Seizure, 20, (1), 2011, p55 - 59
Omer, T.A. Doherty, C., Posterior reversible encephalopathy syndrome (PRES) complicating the 'legal high' mephedrone, BMJ Case Reports , 2011
Naughton, M., Coen, R.F., Doherty, C., Lawlor, B.A, An unusual cause of autobiographical memory loss, Irish Journal of Psychological Medicine, 28, (2), 2011, p97 - 99
Ronan, L. Scanlon, C. Murphy, K. Maguire, S. Delanty, N. Doherty, C.P. Fitzsimons, M., Cortical curvature analysis in MRI-negative temporal lobe epilepsy: A surrogate marker for malformations of cortical development, Epilepsia, 52, (1), 2011, p28 - 34
Kasperavi-iüte, D. Catarino, C.B. Heinzen, E.L. Depondt, C. Cavalleri, G.L. Caboclo, L.O. Tate, S.K. Jamnadas-Khoda, J. Chinthapalli, K. Clayton, L.M.S. Shianna, K.V. Radtke, R.A. Mikati, M.A. Gallentine, W.B. Husain, A.M. Alhusaini, S. Leppert, D. Middleton, L.T. Gibson, R.A. Johnson, M.R. Matthews, P.M. Hosford, D. Heuser, K. Amos, L. Ortega, M. Zumsteg, D. Wieser, H.-G. Steinhoff, B.J. Krämer, G. Hansen, J. Dorn, T. Kantanen, A.-M. Gjerstad, L. Peuralinna, T. Hernandez, D.G. Eriksson, K.J. Kälviäinen, R.K. Doherty, C.P. Wood, N.W. Pandolfo, M. Duncan, J.S. Sander, J.W. Delanty, N. Goldstein, D.B. Sisodiya, S.M., Common genetic variation and susceptibility to partial epilepsies: A genome-wide association study, Brain, 133, (7), 2010, p2136 - 2147
Breen, P., Murphy, K., Browne, G., Molloy, F., Reid, V., Doherty, C., Delanty, N., Connolly, S., Fitzsimons, M., Formative evaluation of a telemedicine model for delivering clinical neurophysiology services part II: The referring clinician and patient perspective, BMC Medical Informatics and Decision Making, 10, (1), 2010
Dunlea, O. Doherty, C.P. Farrell, M. Fitzsimons, M. O'Brien, D. Murphy, K. MacMackin, D. Pender, N. Staunton, H. Phillips, J. Delanty, N., The Irish epilepsy surgery experience: Long-term follow-up, Seizure, 19, (4), 2010, p247 - 252
Breen, P. Murphy, K. Browne, G. Molloy, F. Reid, V. Doherty, C. Delanty, N. Connolly, S. Fitzsimons, M., Formative evaluation of a telemedicine model for delivering clinical neurophysiology services part I: Utility, technical performance and service provider perspective, BMC Medical Informatics and Decision Making, 10, (1), 2010, p48-
Heinzen, E.L. Radtke, R.A. Urban, T.J. Cavalleri, G.L. Depondt, C. Need, A.C. Walley, N.M. Nicoletti, P. Ge, D. Catarino, C.B. Duncan, J.S. Kasperavi-iute, D. Tate, S.K. Caboclo, L.O. Sander, J.W. Clayton, L. Linney, K.N. Shianna, K.V. Gumbs, C.E. Smith, J. Cronin, K.D. Maia, J.M. Doherty, C.P. Pandolfo, M. Leppert, D. Middleton, L.T. Gibson, R.A. Johnson, M.R. Matthews, P.M. Hosford, D. Kälviäinen, R. Eriksson, K. Kantanen, A.-M. Dorn, T. Hansen, J. Krämer, G. Steinhoff, B.J. Wieser, H.-G. Zumsteg, D. Ortega, M. Wood, N.W. Huxley-Jones, J. Mikati, M. Gallentine, W.B. Husain, A.M. Buckley, P.G. Stallings, R.L. Podgoreanu, M.V. Delanty, N. Sisodiya, S.M. Goldstein, D.B., Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes, AJHG, 86, (5), 2010, p707 - 718
O'Connor, G. Ryan, T. Redmond, J. Doherty, C., The value of motor response versus neuroimaging in predicting outcome post cardiac arrest: A retrospective study, Journal of Neurology, 257, (8), 2010, p1400 - 1401
Buckley, A. Fitzgerald, M. Hoerold, D. Davey, G.P. Doherty, C., Effects of the anticonvulsant topiramate on language abilities in people with epilepsy: A cross-sectional study, Irish Journal of Psychological Medicine, 27, (4), 2010, p179 - 183
Sundram, F. Cannon, M. Doherty, C.P. Barker, G.J. Fitzsimons, M. Delanty, N. Cotter, D., Neuroanatomical correlates of psychosis in temporal lobe epilepsy: Voxel-based morphometry study, The British Journal of Psychiatry, 197, (6), 2010, p482 - 492
Richard AP Roche, Sinéad L Mullally, Jonathan P McNulty, Judy Hayden, Paul Brennan, Colin P Doherty, Mary Fitzsimons, Deirdre McMackin, Julie Prendergast, Sunita Sukumaran, Maeve A Mangaoang, Ian H Robertson and Shane M O'Mara, Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain , BMC Neuroscience , 10, 2009, art. no. 136
Lynch, J.M. Tate, S.K. Kinirons, P. Weale, M.E. Cavalleri, G.L. Depondt, C. Murphy, K. O'Rourke, D. Doherty, C.P. Shianna, K.V. Wood, N.W. Sander, J.W. Delanty, N. Goldstein, D.B. Sisodiya, S.M., No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy, Epilepsy Research, 83, (1), 2009, p44 - 51
Gallagher, A., Chu-Shore, C.J., Montenegro, M.A., Major, P., Costello, D.J., Lyczkowski, D.A., Muzykewicz, D., Doherty, C., Thiele, E.A., Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex, Epilepsy Research, 87, (2-3), 2009, p197-202
Kinirons, P. Doherty, C.P., Status epilepticus: A modern approach to management, European Journal of Emergency Medicine: , 15, (4), 2008, p187 - 195
Dardis, S. Farid, S. Doherty, C., Re: New lessons: Classic treatments in convulsive status epilepticus, Irish Medical Journal, 101, (2), 2008
Rational Approach to Status Epilepticus in, editor(s)Jacqueline French and Norman Delanty , Therapeutic Strategies in Epilepsy , USA, Clinical Publishing, 2008, [Doherty C]
Cavalleri, G.L. Walley, N.M. Soranzo, N. Mulley, J. Doherty, C.P. Kapoor, A. Depondt, C. Lynch, J.M. Scheffer, I.E. Heils, A. Gehrmann, A. Kinirons, P. Gandhi, S. Satishchandra, P. Wood, N.W. Anand, A. Sander, T. Berkovic, S.F. Delanty, N. Goldstein, D.B. Sisodiya, S.M., A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy, Epilepsia, 48, (4), 2007, p706 - 712
Shahwan, A. Murphy, K. Doherty, C. Cavalleri, G.L. Muckian, C. Dicker, P. McCarthy, M. Kinirons, P. Goldstein, D. Delanty, N., The controversial association of ABCB1 polymorphisms in refractory epilepsy: An analysis of multiple SNPs in an Irish population, Epilepsy Research, 73, (2), 2007, p192 - 198
McHugh, J.C. Singh, H.W. Phillips, J. Murphy, K. Doherty, C.P. Delanty, N., Outcome measurement after vagal nerve stimulation therapy: Proposal of a new classification, Epilepsia, 48, (2), 2007, p375 - 378
O'Rourke, D. Delanty, N. Doherty, C. White, M. Flynn, C., Potential efficacy of zonisamide in refractory juvenile myoclonic epilepsy: Retrospective evidence from an Irish compassionate-use case series, Irish Medical Journal, 100, (4), 2007
Connolly RM, Doherty CP, Beddy P, O'Byrne K, Chemotherapy induced reversible posterior leukoencephalopathy syndrome., Lung cancer (Amsterdam, Netherlands), 56, (3), 2007, p459-63
Cavalleri, G.L. Weale, M.E. Shianna, K.V. Singh, R. Lynch, J.M. Grinton, B. Szoeke, C. Murphy, K. Kinirons, P. O'Rourke, D. Ge, D. Depondt, C. Claeys, K.G. Pandolfo, M. Gumbs, C. Walley, N. McNamara, J. Mulley, J.C. Linney, K.N. Sheffield, L.J. Radtke, R.A. Tate, S.K. Chissoe, S.L. Gibson, R.A. Hosford, D. Stanton, A. Graves, T.D. Hanna, M.G. Eriksson, K. Kantanen, A.-M. Kalviainen, R. O'Brien, T.J. Sander, J.W. Duncan, J.S. Scheffer, I.E. Berkovic, S.F. Wood, N.W. Doherty, C.P. Delanty, N. Sisodiya, S.M. Goldstein, D.B., Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study, The Lancet Neurology, 6, (11), 2007, p970 - 980
Ronan, L. Murphy, K. Delanty, N. Doherty, C. Maguire, S. Scanlon, C. Fitzsimons, M., Cerebral cortical gyrification: A preliminary investigation in temporal lobe epilepsy, Epilepsia, 48, (2), 2007, p211 - 219
Kinirons, P. McCarthy, M. Doherty, C.P. Delanty, N., Predicting drug-resistant patients who respond to add-on therapy with levetiracetam, Seizure, 15, (6), 2006, p387 - 392
Cummins, F., Doherty, C., Dilley, L., Phrase-final pitch discrimination in english, Proceedings of the International Conference on Speech Prosody, 2006
Ronan, L. Doherty, C.P. Delanty, N. Thornton, J. Fitzsimons, M., Quantitative MRI: A reliable protocol for measurement of cerebral gyrification using stereology, Magnetic Resonance Imaging, 24, (3), 2006, p265 - 272
Kinirons, P. Cavalleri, G.L. Shahwan, A. Wood, N.W. Goldstein, D.B. Sisodiya, S.M. Delanty, N. Doherty, C.P., Examining the role of common genetic variation in the -2 subunit of the GABAA receptor in epilepsy using tagging SNPs, Epilepsy Research, 70, (2-3), 2006, p229 - 238
Kinirons, P. Cavalleri, G.L. O'Rourke, D. Doherty, C.P. Reid, I. Logan, P. Liggan, B. Delanty, N., Vigabatrin retinopathy in an irish cohort: Lack of correlation with dose, Epilepsia, 47, (2), 2006, p311 - 317
Kinirons, P. Cavalleri, G.L. Singh, R. Shahwan, A. Acheson, J.F. Wood, N.W. Goldstein, D.B. Sisodiya, S.M. Doherty, C.P. Delanty, N., A pharmacogenetic exploration of vigabatrin-induced visual field constriction, Epilepsy Research, 70, (2-3), 2006, p144 - 152
The Neurology of Thyroid Disease in, editor(s)John Noseworthy , Neurological Therapeutics, Principles and Practice , USA, Mayo Clinic Publications, 2006, pp1455 - 1463, [Doherty CP]
Doherty, C.P., Possibly, probably definitely, Hashimoto encephalopathy, Journal of the Neurological Sciences, 228, (1), 2005, p1 - 2
Doherty, C., Goh, S., Poussaint, T.Y., Erdag, N., Thiele, E.A., Prognostic significance of tuber count and location in tuberous sclerosis complex, Journal of Child Neurology, 20, (10), 2005, p837-841
Doherty, C.P. Cole, A.J. Grant, P.E. Fischman, A. Dooling, E. Hoch, D.B. White, T.H. Cosgrove, G.R., Multimodal longitudinal imaging of focal status epilepticus, Canadian Journal of Neurological Sciences, 31, (2), 2004, p276 - 281
Doherty, C.P. West, W.C. Dilley, L.C. Shattuck-Hufnagel, S. Caplan, D., Question/statement judgments: An fMRI study of intonation processing, Human Brain Mapping, 23, (2), 2004, p85 - 98
Paulus, W. Nolte, K.W. Doherty, C.P. Folkerth, R., Neuropathology of Hashimoto's encephalopathy [7] (multiple letters), J Neurol Neurosurg Psychiatry , 74, (7), 2003, p1009-
Portera-Cailliau, C. Doherty, C.P. Buonanno, F.S. Feske, S.K., Middle cerebral artery territory infarction sparing the precentral gyrus: Report of three cases, J Neurol Neurosurg Psychiatry , 74, (4), 2003, p510 - 512
Oster, J. Doherty, C. Grant, P.E. Simon, M. Cole, A.J., Diffusion-weighted imaging abnormalities in the splenium after seizures, Epilepsia, 44, (6), 2003, p852 - 854
Doherty, C.P. Fitzsimons, M. Meredith, G. Thornton, J. McMackin, D. Farrell, M. Phillips, J. Staunton, H., Rapid stereological quantitation of temporal neocortex in TLE, Magnetic Resonance Imaging, 21, (5), 2003, p511 - 518
Doherty, C.P. Schlossmacher, M. Torres, N. Bromfield, E. Samuels, M.A., Hashimoto's encephalopathy mimicking Creutzfeldt-Jakob disease: Brain biopsy findings [6], J Neurol Neurosurg Psychiatry , 73, (5), 2002, p601 - 602
St. George, E.J. Plowman, P.N. Doherty, C.P. Hoch, D. Cole, A.J. Richards, T.A. Stephen, L.J. Brodie, M.J. Wiebe, S. Blume, W.T. Engel Jr., J., Surgery for temporal-lobe epilepsy [3] (multiple letters), New England Journal of Medicine, 346, (4), 2002, p292 - 295
, Surgery for temporal-lobe epilepsy, The New England journal of medicine, 2002
Erickson, A.B., Hayashi, J., Doherty, C., Pierach, C.A., Lohiya, G.-S., Kassirer, J.P., Free meals from the pharmaceutical industry, Journal of the American Medical Association, 285, (2), 2001, p164-166
, The requirement for ictal EEG recordings prior to temporal lobe epilepsy surgery, Archives of neurology, 2001
Bothwell, S., Meredith, G.E., Phillips, J., Staunton, H., Doherty, C., Grigorenko, E., Glazier, S., Deadwyler, S.A., O'Donovan, C.A., Farrell, M., Neuronal hypertrophy in the neocortex of patients with temporal lobe epilepsy, Journal of Neuroscience, 21, (13), 2001, p4789-4800
Doherty, C., Neurologic manifestations of thyroid disease, Neurologist, 7, (3), 2001, p147 - 157
Doherty, C., Free meals from the pharmaceutical industry., Journal of the American Medical Association, 285, (2), 2001
Doherty, C.P. Cole, A.J. Cendes, F. Andermann, F. Dubeau, F., The requirement for ictal EEG recordings prior to temporal lobe epilepsy surgery [3] (multiple letters), Archives of Neurology, 58, (4), 2001, p678 - 680
Erickson, A.B., Hayashi, J., Doherty, C., Pierach, C.A., Lohiya, G.-S., Kassirer, J.P., Free meals from the pharmaceutical industry [2] (multiple letters), JAMA, 285, (2), 2001, p164-166
, Accuracy and validity of stereology as a quantitative method for assessment of human temporal lobe volumes acquired by magnetic resonance imaging, Magnetic resonance imaging, 2000
Doherty, C.P. Fitzsimons, M. Asenbauer, B. McMackin, D. Bradley, R. King, M. Staunton, H., Prosodic preservation in Landau-Kleffner syndrome: A case report, European Journal of Neurology, 6, (2), 1999, p227 - 234
, Radiological determination of the posterior limits of the temporal lobe for volumetric analysis, Brain research. Brain research protocols, 1999
Doherty, C.P. Fitzsimons, M. Asenbauer, B. Staunton, H., Discrimination of prosody and music by normal children, European Journal of Neurology, 6, (2), 1999, p221 - 226
O'Riordan, J.I. Doherty, C. Javed, M. Brophy, D. Hutchinson, M. Quinlan, D., Do Alpha-Blockers Have a Role in Lower Urinary Tract Dysfunction in Multiple Sclerosis?, The Journal of Urology, 153, (4), 1995, p1114 - 1116
Cullinan, C., Doherty, C., Kellett, J., Letter to the editor - Thrombotic Stroke as a Complication of Heparin-induced Thrombocytopenia, Irish Journal of Medical Science, 163, (6), 1994, p314
O'Riordan, J. Javed, M. Doherty, C. Hutchinson, M., Worsening of myasthenia gravis on treatment with imipenem/cilastatin [4], Journal of Neurology Neurosurgery and Psychiatry, 57, (3), 1994, p383-
Non-Peer-Reviewed Publications
McNamara, P.H. Redmond, J.M.T. Doherty, C.P., Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod, Neurology, 81, (3), 2013, p306-
Research Expertise
Description
I have published widely in the areas of brain imaging in epilepsy, the genetics of epilepsy, functional imaging of language, dementia, clinical neurology and epileptology and traumatic brain injury. In the last few years I have become interested in the challenges of population health, health services research and care delivery in epilepsy. I have published recently on national issues regarding epilepsy care including; evidence based pathways, national mortality estimates, hospital access restrictions and national prescribing rates. I have 105 peer reviewed publications, 4211 citations, a H-index of 35 and i10index of 78. My latests research projects are 1. Brain imaging in CoVID brain Fog and Anosmia 2. Brain imaging in retired contact sports players 3. Brain imaging in patients with epilepsy and rare genetic disorders 4. Evaluating the e-health needs of the epilepsy population 5. Evaluating a patient portal for epilepsy patients 6. Evaluating an outreach service for vulnerable patients with epilepsy 7. Evaluating the mental, social and physical health of patients with epilepsy during CoVID 8. Exam sequencing for rare forms of epilepsy and intellectual disability 9. Collecting biomarkers of seizures for diagnosis and prognosisProjects
- Title
- Circulating Biomarkers in Epilepsy
- Summary
- During the first two years of operation, research in WP3, 4 and 7 led to the identification of circulating microRNAs in plasma that are biomarkers of epilepsy and acute seizures 1, three tRNA fragments (or 'tsRNAs') that increase in advance of epileptic seizures 2, and the development of rapid-detection technology for these 3,4. FutureNeuro genomics work in WP1 has shown that 1-3% of sporadic epilepsy is caused by identifiable monogenic causes (unpublished/in preparation). We also have an increased understanding of the contribution of genetic burden to disease risk. For example, over the past 3 years the community has illustrated how focal and generalised epilepsies show an enrichment for both common and rare genetic burden 5,6. The predictive ability of genetic burden for disease state will increase steadily as ever larger collaborative studies emerge. The challenge now is to understand how these signatures correlated with treatment outcome. In addition, bioinformatics studies have shown mechanistic links between some of the targets of these circulating miRNAs and proteins present in plasma that can be measured that may correlate with neurophysiological phenotypes or responses to anti-miRNA therapies in epilepsy and Rett syndrome, a neurodevelopmental disorder accompanied by seizures (Henshall/Tropea, unpublished data). There are significant industry interests in these advances with negotiations underway with UCB Pharma to perform microRNA and genetic profiling to define the molecular landscape of drug-resistant epilepsy. Together, these discoveries have led to FutureNeuro having a leading position in the area of circulating diagnostic biomarkers that was recognised during the recent two-year Site Visit. We propose to capitalise on our leading position in this field and genomics during the remaining funding period. Broadly, we want to explore the value of these biomarkers at the earliest stage of the patient journey (i.e. upon first presentation of a seizure), test the benefits of different combinations of the biomarkers for epilepsy and rare diseases (Rett syndrome), extend evidence for pathophysiological links to disease, and begin the process of commercialisation toward a clinical/diagnostic test using either existing technology or techniques developed by the Centre. Background to proposal for years 3-6 Epilepsy affects 40,000 people in Ireland and the majority will present to the emergency room at some point in the course of their illness. However, more than half of the 7,000 or so admissions in Ireland every year are not people with epilepsy but those with symptomatic seizures related to intoxication with alcohol and other drugs; head injuries; brain infections and other serious illnesses. There are also a large number of mimic syndromes such as psychogenic non-epileptic seizures, recurrent fainting and collapses of unknown cause. Finding biomarkers that can distinguish between a. Epileptic seizures and non-epileptic attacks as well as other mimic disorders. b. Epileptic seizures and symptomatic seizures (such as alcohol withdrawal seizures). c. Epileptic seizures that will result in severe refractory disease as opposed to an isolated event. would be extremely scientifically interesting, clinically valuable, timesaving and economically beneficial for the health system.
- Funding Agency
- SFI
- Date From
- Sept 2020
- Date To
- Sept 2023
- Title
- From the Outside-In' - Co-Designing Tools to Promote Independence and Wellbeing in Epilepsy Care
- Summary
- Qualitative Study 'From the Outside-In': A qualitative study involving PWE, their carers and healthcare practitioners (HCP) This study will be an in-depth examination of the thoughts, opinions and behaviours of PWE, carers and HCP with regard to how they approach self-management of the condition, what supports they use and where they believe improvement is needed. This research will utilise 'co-production' to generate ideas for the future of epilepsy care provision in Ireland. Patients seldom are given a voice when it comes to such design of healthcare services - hence the study being provisionally titled 'From the Outside-In: Co-Designing Tools to Promote Independence and Wellbeing in Epilepsy Care'. Within the cohort recruited for qualitative research will be homeless PWE, keyworkers and clinicians working with Safetynet Homeless Service. I have become a member of the All Ireland Inclusion Health forum's Research Advisory Group (AIHF RAG) with a view to researching the challenges faced specifically by homeless PWE and clinicians working in the care of homeless patients. There are three work-streams planned for this study. Work-stream 1 involves obtaining ethical approval, creating consent forms, participant information leaflets and a data protection impact assessment. It also involves design of the ethnography, interviews and focus groups.
- Funding Agency
- SFI
- Date From
- Sept 2018
- Date To
- Sept 2021
- Title
- Analysing blood-brain barrier integrity to inform on protection from CoVID-19 associated encephalopathy.
- Summary
- Rationale: The CoVID-19 virus is genetically similar to other zoonotic coronaviruses that can cause brain damage in animals. The ACE-2 receptor, thought to be the cellular invasion point, is widely expressed in the cerebral vasculature. Despite this, clinical observations in Ireland and elsewhere of the spectrum of neurological complications are large enough now to tell us, at least in this acute phase, that there is no unique neurological signature of CoVID-19 apart possibly from anosmia (loss of the sense of smell) that has been observed in 30-50% of cases. This indicates some protective processes in the human brain and the presence of anosmia points to one possible candidate, the Blood Brain Barrier (BBB) which is heterogeneous within the olfactory bulb with areas of less evolved barrier integrity. Aim: To determine the integrity of the BBB in acute and convalescent cases of CoVID-19 patients, with and without neurological symptoms in particular anosmia. Significance: A strong protective function for the BBB in supressing brain invasion may have significance for future therapies as well as policy and health service planning for any future pandemics. Objective neurological imaging combined with serological assessments may also hold enormous prognostic value in the short term.
- Funding Agency
- SFI/EI
- Date From
- August 2020
- Date To
- April 2021
Recognition
Representations
Clinical Lead for the National Epilepsy Programme
I have been a member of the board of the health research board (HRB)
I was a member of the governments National Clinical Effectiveness Committee.
Irish representative to the International League Against Epilepsy (ILAE) committee for the Global Campaign Against Epilepsy
Founder member of Epilepsy Research Ireland
Clinical Lead for Women's Health in Epilepsy
Member of Irish government's expert group on resource allocation
adjunct Professor department of Disability, University College Dublin
Awards and Honours
Epilepsy Prize Irish Neurological Association
Lundbeck Research Prize
Care Challenge Award
Fritz Dreifuss Award for Clinical Research
Merritt-Putnam Fellowship Award
Epifellows Foundation Fellowship Award 2001
AAN Resident Traveling Scholarship Award
Daniel C. Federman Award for Outstanding Clinical Teaching.
Harold Millar Medal
Memberships
Fellowship of RCPI
Fellow of the faculty of exercise and Sports medicine
American Epilepsy Society
Irish Institute of Clinical Neuroscience
Irish Epilepsy League
European Academy of Neurology