Dr. Conor Finlay
Senior Research Fellow, Trinity Translational Medicine Institute
Biography
I started my career at Trinity College Dublin under Prof Kingston Mills, where I used pre-clinical models of autoimmunity to identify pathways that shut down inflammation. I focused on how anti-inflammatory `type 2" immune responses regulated the inflammatory `type 1" responses. My interest in type 2 immune responses and myeloid cells brought me to a world-leading macrophage lab at the University of Manchester, under Prof Judi Allen. In Manchester, I retrained in bioinformatics, enabling me to understand project delivery from a multi-disciplinary point of view. Most recently, I moved into translational research at the Trinity Translational Medicine Institute (TTMI) gaining skills in patient-focused research, including in clinical data analysis and study design and facilitating collaboration with clinician-scientitst.
Publications and Further Research Outputs
Peer-Reviewed Publications
Finlay, Conor M and Allen, Judith E, IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging., Immunity, 57, (3), 2024, p403--406
Ridge, Katie and Moran, Barry and Alvarado-Vazquez, P. Abigail and Hallgren, Jenny and Little, Mark A. and Irvine, Alan D. and O'Farrelly, Cliona and Dunne, Jean and co-senior). Finlay, Conor M (co-corresponding & and Conlon, Niall, Lin-CD117+CD34+FceRI+ progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti-IgE therapy, Allergy, In Press, 2024
Han Jichan, Gallerand Alexandr, Erlich Emma C, Helmink Beth A, Mair Iri, Li Xi, Eckhouse Shaina R, Dimou Francesca M, Shakhsheer Baddr A, Phelps Hannah M, Chan Mandy M, Mintz Rachel L, Lee Daniel D, Schilling Joel D, Finlay Conor M, Allen Judith E, Jakubzick Claudia V, Else Kathryn J, Onufer Emily J, Zhang Na, Randolph Gwendalyn J, Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species, Nature Immunology, 25, (1), 2024, p155 - 165
Tachó-Piñot R, Stamper CT, King JI, Matei-Rascu V, Richardson E, Li Z, Roberts LB, Bassett JW, Melo-Gonzalez F, Fiancette R, Lin IH, Dent A, Harada Y, Finlay C, Mjösberg J, Withers DR, Hepworth MR., Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3., Cell reports, 42, (11), 2023, p113425
Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H.K. Chan, Jesuthas Ajendra, Alistair Chenery, Anya Morrison, Irem Kaymak, Emma L. Houlder, Syed Murtuza Baker, Ben R. Dickie, Louis Boon, Joanne E. Konkel, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Rückerl, Judith Allen, T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity, Immunity, 2023
Caitlin M. McManus, Tiffany Bouchery, Mona Suleiman, Anna O. Kildemoes, Annabel Ferguson, Tao Wang, Conor M. Finlay, Ryan Chan, Tess Renahan, Ananya Mukundan, Gyaviira Nkurunungi, Sarah D. Bobardt, Hydra 2022: return of the interactive conference on helminth parasitology after the pandemic, Trends in Parasitology, 2022
Fiancette R, Finlay CM, Willis C, Bevington SL, Soley J, Ng STH, Baker SM, Andrews S, Hepworth MR, Withers DR., Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity., Nature immunology, 22, (10), 2021, p1245-1255
Cunningham Kyle , Finlay Conor , Mills Kingston H, Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease, Journal of Immunology, 206, (7), 2021, p1618 - 1630
Finlay, C.M. and Cunningham, K.T. and Doyle, B. and Mills, K.H.G., IL-33-stimulated murine mast cells polarize alternatively activated macrophages, which suppress T cells that mediate experimental autoimmune encephalomyelitis, Journal of Immunology, 205, (7), 2020, p1909-1919
Finlay Conor , Allen Judith, The immune response of inbred laboratory mice to Litomosoides sigmodontis : A route to discovery in myeloid cell biology, Parasite Immunology, 42, (7), 2020, pe12708 - e12708
McEntee, C.P. and Finlay, C.M. and Lavelle, E.C., Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation, Frontiers in Immunology, 10, (JUN), 2019
Czajkowska Beata I, Finlay Conor , Jones Glyni, Brown Terence A, Diversity of a cytokinin dehydrogenase gene in wild and cultivated barley, PLOS one, 14, (12), 2019, pe0225899 - e0225899
Campbell Sharon , Knipper Johanna , Ruckerl Domini, Finlay Conor , Logan Nicol, Minutti Carlos , Mack Matthia, Jenkins Stephen , Taylor Matthew , Allen Judith, Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection, eLife, 7, 2018, pe30947 - e30947
Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923-
Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 -
Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714
Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992
Finlay CM, Walsh KP, Mills KH, Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases., Immunological reviews, 259, (1), 2014, p206-30
Coleman, M.M., Finlay, C.M., Moran, B., Keane, J., Dunne, P.J., Mills, K.H., The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis, FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413-424
Walsh, KP, Brady, MT, Finlay, CM, Boon, L, Mills, KH, Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses., Journal of Immunology , 183, (3), 2009, p1577 - 1586
Non-Peer-Reviewed Publications
Animal Models of ANCA Vasculitis in, editor(s)Aman Sharma , Textbook of Systemic Vasculitis 2nd Edition, 2023, [Conor M Finlay, Mark A Little]
CP McEntee, S Houston, CM Finlay, S Rossi, G Liu, TN Shaw, J Casulli, M Fife, C Smedley, View ORCID ProfileTS Griffith, View ORCID ProfileM Pepper, T Hussell, PM Hansbro, View ORCID ProfileJ-M Schwartz, H Paidassi, MA Travis, A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFß, BioRxiv, (2023.03.02.527395), 2023
Research Expertise
Description
I am a Cellular Immunologist and bioinformatician who combines molecular, in vivo and translational research. My main reserach interest is in the differentiation and function of monocnuclear phagocytes (monocytes, macrophages and dendritic cells) in tissues during inflammation. I am particularly interested in how classically inflammatory "Type 1" immune responses and anti-inflammatory "Type 2" immmune response affect the differentiation paths that macrophages take in tissues. To study these concepts in diseases of two organs, the Kidney and the pleural cavity. I have a long-term interests in cell-cell interactions during infection and autoimmunity, particularly in how T cells instuct myeloid cells like macrophages, neutrophils, eosinophils and mast cells.Projects
- Title
- Macrophages in type 2 immunity: unravelling susceptibility and resistance to tissue nematode infection
- Summary
- Helminth infection is characterised by a type 2 immune response with polarisation of macrophages toward an M(IL-4) phenotype. It is increasingly recognised that macrophage functionality relies not only on direct cytokine signals but cellular origin and tissue environment. This programme is built around the pleural cavity, a tissue containing two predominant macrophage populations: monocyte-derived small cavity macrophages (SCMac) and large cavity macrophages (LCMac) which have a 'residency' gene expression module, conferred by the tissue niche. We will use the filarial nematode Litmosoides sigmodontis (Lito) as a model of pleural infection and as a tool to study M(IL-4) cells more generally. Mirroring divergent outcomes in human filariasis, susceptibility to Lito infection is dependent on host genotype, with striking differences in M(IL-4) cells between resistant and susceptible strains of mice. In resistant C57BL/6 mice LCMac expand greatly through proliferation and become M(IL-4) polarised. In susceptible BALB/c mice there are relatively more SCMac like cells which appear incapable of acquiring a full LCMac-residency or M(IL-4) programme. Aim 1 seeks to explain if strain differences are a result of intrinsic differences in macrophage programming, alterations of the tissue niche or due to differences in Th2 cell activity. The next 2 aims focus on resistant C57BL/6 mice as a model of type 2 immunity culminating in worm killing. Aim 2 looks upstream of macrophages to identify the cell-cell interactions in the pleural cavity and essential co-factors that drive M(IL-4) polarisation and proliferation. Aim 3 will look downstream of M(IL-4) cells to assess their contribution to worm killing and tissue integrity in the pleural cavity using mice which lack specific residency, M(IL-4) or proliferation gene modules. This programme will advance our knowledge of the activation and function of M(IL-4) cells and provide novel information on the function of the pleural space.
- Funding Agency
- Medical Research Council
- Title
- COVID-19 Strategic Partnership
- Summary
- Work package 2 'Immune responses and disease pathogenesis in COVID-19 patients
- Funding Agency
- SFI
- Date From
- 01/03/2021
- Title
- Nanoparticle modulation of neutrophil and monocyte responses to ANCA'
- Summary
- ANCA Vasculitis is a potentially lethal autoimmune disease, whereby the immune system is triggered to self-destruct - the systems normally primed to fight infection and cancer cells are incorrectly activated, resulting in damage to the blood vessels and eventually organ destruction, such as kidney failure. Auto-antibodies (proteins against oneself) bind to immune cells (neutrophils and monocytes) in the blood, improperly activating these cells and driving the development of ANCA vasculitis. The exact cause of ANCA vasculitis has yet to be discovered. Evidence suggests there is a complex interaction between a person's genetic make-up and unknown triggers in their environment. Silica dust, a common occupational hazard for construction workers amongst others, is the leading proposed environmental toxin. However, how exposure to silica influences the development of ANCA-vasculitis is unknown. We will address this by exploring the effects of silica on the same auto antibody-activated immune cells, which underpin ANCA vasculitis. These experiments will help explain the early events in ANCA vasculitis and may help to identify new treatments for this disease.
- Funding Agency
- TTMI - internal
- Date From
- 19/04/2021
- Title
- Understanding mast cells and their progenitors in Telangiectasia Macularis Eruptiva Perstans (TMEP)'
- Funding Agency
- TTMI - Internal
- Title
- Mapping human macrophage anti-microbial function in pleural infection.
- Funding Agency
- Trinity College Dublin
Recognition
Awards and Honours
Best presentation from selected abstracts - Irish Society of Immunology
Visiting student training scheme - Weizmann Institute of Science
Valdicotrian - Biochemistry with Immunology degree
Best Undergraduate Research Poster Prize - School of Biochemistry and Immunology
TBSI Post-Doc Research Day - Runner up talk prize
Wiley Top Cited Article Award - Parasite Immunology
EFIS/EJI Travel/Abstract Award Winners Presenting at Cytokines 2021
Memberships
British society of Immunology