Competencies & Equipment

Drug design, synthesis, purification & characterisation
Conventional and microwave synthetic technologies
Combinatorial /Library design
Drug discovery from Natural Products
Structure-activity relationships
Drug stability studies
Mass spectrometry
Molecular biology, including cloning
Site-directed mutagenesis
Reporter gene expression studies
Genotyping, SNPs and VNTRs identification
Mammalian cell culture (class 10,000 clean rooms)
Protein-based assays
Cellular-based assays including:
Morphology
Anti-proliferative /cytotoxic
Cell cycle, migration
Invasion
Apoptosis /anoikis
Tubule formation & angiogenesis
Ex vivo: aortic ring assay of angiogenesis/vasculature
In vivo xenograft models for efficacy, necrosis and tumour vasculature shutdown
Quartz Crystal Microbalance with Dissipation (QCM-D)
Nano-toxicology evaluation
Tumour cell-induced platelet aggregation (TCIPA) analysis
Exosomes isolation & characterisation
Pre-formulation studies
Solid state characterisation
In vitro aerosol deposition characterisation
Pharmaceutical processing methods:
Milling
Spray drying
Freeze drying
Compaction
Thermal analysis infrared spectroscopy
Powder X-ray diffraction
Micromeritic properties analysis
Nanoparticle characterisation
Pharmacokinetic & pharmacodynamic studies
Physicochemical characterisation salts, cocrystals, amorphous, polymeric APIs forms
Spray drying
Translational clinical trials (with ICORG and first-in-man through spinouts companies)
Pharmacoeconomics
IP disclosure & patent filing

Access to Core Facilities:

Class 10,000 cleanrooms for mammalian cell culture

Microarrays, qPCR

advanced microscopy (confocal microscopy, transmission & scanning electron microscopy)

Fluorescence-activated cell sorting (FACS)

NMR, X-Ray, MS

In vivo core

The School of Pharmacy and Pharmaceutical Sciences welcomes new partners and collaborators.

The School of Pharmacy & Pharmaceutical Sciences,

Panoz Institute,

Trinity College,

Dublin 2,

Ireland.