TCD Campus Company, Opsona Therapeutics Secures €33m Funding

Posted on: 07 May 2013

Opsona Therapeutics, a Trinity College campus biotechnology company focused on novel therapeutic and preventative approaches to autoimmune and inflammatory diseases announced the completion of an €33m financing. Opsona Therapeutics was founded in 2004 by three of Trinity College Dublin’s immunologists: Professor of Biochemistry, Luke O’Neill and Professor of Experimental Immunology, Kingston Mills – both at the School of Biochemistry and Immunology along with  former Professor of Medicine, Dermot Kelleher.

Opsona is developing new treatments for inflammatory diseases and will use the proceeds to conduct a two-part multi-centered, double blinded and placebo controlled clinical study to evaluate the safety, tolerability and efficacy of its lead product OPN-305 in renal transplant patients at high risk of Delayed Graft Function (DGF). This is the first clinical indication for OPN-305, a fully human monoclonal IgG4 antibody targeting Toll-like-receptor-2 (TLR2). Opsona recently completed a successful Phase I clinical trial in healthy human volunteers and has also demonstrated activity in preclinical animal models and ex-vivo studies. This first-in-class inhibitor of TLR2 has the advantage of inhibiting multiple cytokines leading to the pathogenesis of the complex inflammatory response in various diseases (ischemia/reperfusion injuries, rheumatoid arthritis, diabetes, lupus, nephritis and various cancers) and has therefore a potentially broad application potential.

The company raised €33 million in an oversubscribed Series C financing. The participants in this Series C financing include existing investors, Novartis Venture Fund, Fountain Healthcare Partners, Roche Venture Fund and Seroba Kernel Life Sciences. The new investors joining the consortium are BB Biotech Ventures, Sunstone Capital, Baxter Ventures, Amgen Ventures, and EMBL Ventures.

Dr. Martin Welschof, CEO of Opsona, commented: “The innate immune system represents a new frontier in targeting inflammatory diseases, and the quality of venture and corporate investors in this funding round is a demonstration of Opsona’s expertise and capabilities in this highly promising field. “