Functional Genomics of Pathogenic Bacteria

To adapt and respond to changing conditions during infection and in the environment, bacteria possess the remarkable ability to modulate their gene expression programs quickly and efficiently. We use whole genome (Next-Generation Sequencing, RNA-seq) and gene-specific methods to study transcriptional networks, mechanisms, and antibiotic resistance of Gram-negative pathogens and their regulation (by small RNAs and protein transcription factors) to understand how bacterial pathogens sense, respond, and survive during environmental changes.