Dr. Nicky O'Boyle

• Rimbi PT, O'Boyle N, Douce GR, Pizza M, Rosini R, Roe AJ., Enhancing a multi-purpose artificial urine for culture and gene expression studies of uropathogenic Escherichia coli strains., Journal of applied microbiology, 135, (4), 2024, plxae067Journal Article, 2024, DOI
• O'Boyle N, Douce GR, Farrell G, Rattray NJW, Schembri MA, Roe AJ, Connolly JPR., Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection., Proceedings of the National Academy of Sciences of the United States of America, 120, (1), 2023, pe2212175120Journal Article, 2023, DOI
• Hallam JC, Sandalli S, Floria I, Turner NCA, Tang-Fichaux M, Oswald E, O'Boyle N, Roe AJ., D-Serine reduces the expression of the cytopathic genotoxin colibactin., Microbial cell (Graz, Austria), 10, (3), 2023, p63-77Journal Article, 2023, DOI
• Connolly JPR, Turner NCA, Serrano E, Rimbi PT, Browning DF, O'Boyle N, Roe AJ., Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associated Escherichia coli., Proceedings of the National Academy of Sciences of the United States of America, 119, (45), 2022, pe2210299119Journal Article, 2022, DOI
• O'Boyle N, Roe AJ., Heterogeneity in populations of enterohaemorrhagic Escherichia coli undergoing D-serine adaptation., Current genetics, 67, (2), 2021, p221-224Journal Article, 2021, DOI
• Mordue J, O'Boyle N, Gadegaard N, Roe AJ., The force awakens: The dark side of mechanosensing in bacterial pathogens., Cellular signalling, 78, 2021, p109867Journal Article, 2021, DOI
• Connolly JPR, Roe AJ, O'Boyle N., Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria., Critical reviews in microbiology, 47, (1), 2021, p126-140Journal Article, 2021, DOI
• Fox S, Goswami C, Holden M, Connolly JPR, Mordue J, O'Boyle N, Roe A, Connor M, Leanord A, Evans TJ., A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage., Scientific reports, 10, (1), 2020, p4135Journal Article, 2020, DOI
• O'Boyle N, Turner NCA, Roe AJ, Connolly JPR., Plastic Circuits: Regulatory Flexibility in Fine Tuning Pathogen Success., Trends in microbiology, 28, (5), 2020, p360-371Journal Article, 2020, DOI
• Connolly JPR, O'Boyle N, Roe AJ., Widespread Strain-Specific Distinctions in Chromosomal Binding Dynamics of a Highly Conserved Escherichia coli Transcription Factor., mBio : Duplicate, marked for deletion, 11, (3), 2020, pe01058-20Journal Article, 2020, DOI
• O'Boyle N, Connolly JPR, Tucker NP, Roe AJ., Genomic plasticity of pathogenic Escherichia coli mediates d-serine tolerance via multiple adaptive mechanisms., Proceedings of the National Academy of Sciences of the United States of America, 117, (36), 2020, p22484-22493Journal Article, 2020, DOI
• O'Boyle N, Berry CC, Davies RL., Differentiated ovine tracheal epithelial cells support the colonisation of pathogenic and non-pathogenic strains of Mannheimia haemolytica., Scientific reports, 10, (1), 2020, p14971Journal Article, 2020, DOI
• McHugh RE, O'Boyle N, Connolly JPR, Hoskisson PA, Roe AJ., Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis., Infection and immunity, 87, (2), 2019, pe00595-18Journal Article, 2019, DOI
• Connolly JPR, O'Boyle N, Turner NCA, Browning DF, Roe AJ., Distinct intraspecies virulence mechanisms regulated by a conserved transcription factor., Proceedings of the National Academy of Sciences of the United States of America, 116, (39), 2019, p19695-19704Journal Article, 2019, DOI
• Connolly JPR, Turner NCA, Hallam JC, Rimbi PT, Flett T, McCormack MJ, Roe AJ, O'Boyle N, d-Serine induces distinct transcriptomes in diverse Escherichia coli pathotypes., Microbiology (Reading, England), 2021Journal Article, 2021, DOI
• Nicky O'Boyle, Aoife Boyd, Validation of a random Vibrio parahaemolyticus genomic library by selection of quinolone resistance in a heterologous host, Microbiology, 168, (5), 2022Journal Article, 2022, DOI
• O'Boyle N, Boyd A., Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus., Frontiers in cellular and infection microbiology, 3, 2014, p114Journal Article, 2014, DOI
• O'Boyle N, Houeix B, Kilcoyne M, Joshi L, Boyd A., The MSHA pilus of Vibrio parahaemolyticus has lectin functionality and enables TTSS-mediated pathogenicity., International journal of medical microbiology : IJMM, 303, (8), 2013, p563-573Journal Article, 2013, DOI
• O'Boyle N, Sutherland E, Berry CC, & Davies RL, Temporal dynamics of ovine airway epithelial cell differentiation at an air-liquid interface., PloS one, 12, (7), 2017, pe0181583Journal Article, 2017, DOI
• Connolly JPR, Turner NCA, Hallam JC, Rimbi PT, Flett T, McCormack MJ, Roe AJ, O'Boyle N, D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes., Microbiology, 167, (10), 2021, p001093Journal Article, 2021, URL
• Connolly JP, Slater SL, O"Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DG, Douce GR, Frankel G, Roe AJ, Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion., Nature Communications., 9, (1), 2018, p4187Journal Article, 2018
• O'Boyle N, Sutherland E, Berry CC, & Davies RL, Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface., Plos one, 13, (3), 2018, pe0193998Journal Article, 2018, URL
• O'Boyle N, Connolly JPR, & Roe AJ, Tracking elusive cargo: Illuminating spatio"temporal Type 3 effector protein dynamics using reporters., Cellular Microbiology, 20, (1), 2018, pe12797Journal Article, 2018, URL
• Connolly JPR, Turner NCA, Hallam JC, Rimbi PT, Flett T, McCormack MJ, Roe AJ, O'Boyle N, Transcriptional response to D-serine stress in distinct E. coli pathotypes, 1, MORF Open Science, 2024Dataset, 2024
• Kabo R Wale, Nicky O'Boyle, Rebecca McHugh, Ester Serrano, David Mark, Gillian R Douce, James PR Connolly, Andrew J Roe, A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens, PLoS Pathogens, 20, (10), 2024, pe1012451Journal Article, 2024
• DR Mark, N O'Boyle, KR Wale, SK Tucker, RE McHugh, AJ Roe, Aurodox inhibits type III secretion in multiple Gram-negative pathogens, Open Biology, 14, (11), 2024, p240240Journal Article, 2024

• Title

  Deciphering Blue Ecosystem Chemical Communication Networks for Sustainable Next Generation solutions to the Antimicrobial Resistance Crisis.
  Summary
  Funding Agency

  Irish Research Council
  Date From

  02/09/24
  Date To

  02/092028
• Title

  D-serine: A dietary solution to enteric infection or a potentiator of pathogen evolution?
  Summary
  Funding Agency

  Tenovus Scotland
  Date From

  01/11/2019

Probiotics, Veterinary pathology, Veterinary bacteriology, Analytical chemistry not elsewhere classified, Genome structure and regulation, Medical biochemistry - amino acids and metabolites, Metabolomic chemistry, Infectious diseases, Medical biochemistry - carbohydrates, Medical biochemistry - inorganic elements and compounds, Molecular evolution, Separation science, Medical bacteriology, Medical biochemistry - nucleic acids, Animal cell and molecular biology, One health, Medical microbiology, Personalised medicine, Microbial genetics, Gene expression (incl. microarray and other genome-wide approaches), Animal immunology, Nutritional science, Gastroenterology and hepatology, Medical biotechnology diagnostics (incl. biosensors), Veterinary antimicrobial resistance, Microbiology, Microbial ecology, Natural products and bioactive compounds, Molecular imaging (incl. electron microscopy and neutron diffraction), Medical molecular engineering of nucleic acids and proteins, Medical biochemistry - proteins and peptides (incl. medical proteomics), Bacteriology, Medical genetics (excl. cancer genetics), Drug discovery, design and delivery, Animal physiology - cell, Agricultural, veterinary and food sciences, Metabolic medicine, Major global burdens of disease, Clinical microbiology, Animal protection (incl. pests and pathogens), Infectious agents, Genomics, Genetics,

• SEFS New Connections Grant (University College, Cork) March, 2022
• Microbiology Society Travel/Conference Grant January 2016
• SEFS New Connections Summer Research Bursary (University College, Cork) May, 2023
• Microbiology Society Travel/Conference Grant January 2018
• Federation of European Biochemical Societies Youth Travel Fund (YTF) Fellowship August, 2009
• Microbiology Society Travel/Conference Grant January 2017
• Microbiology Society Travel/Conference Grant January 2009
• Microbiology Society Travel/Conference Grant January 2016
• Microbiology Society Travel/Conference Grant January 2012
• Microbiology Society Travel/Conference Grant January 2019
• Professor L. Kieran Dunican Memorial Medal (NUI, Glaway) June, 2008
• Tenovus Scotland Pilot Grant (Tenovus Scotland) November 2019

• Irish Division of the Microbiology Society
• Microbiology Society