Microbiology

Contact Us Department of Microbiology
Moyne Institute of Preventive Medicine
School of Genetics and Microbiology
Trinity College Dublin
Dublin 2
Ireland

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magoverj@tcd.ie Gaeilge
Dr. Alastair Fleming

Dr. Alastair Fleming

Associate Professor, Microbiology

3531896 3112http://www.tcd.ie/Microbiology/research/alastair-fleming/

Publications and Further Research Outputs

  • Fleming, AB, Beggs S, Church M, Tsukihashi Y, Pennings S., The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene., Biochim Biophys Acta - Gene regulatory Mechanisms, 1839, (11), 2014, p1242 - 1255Journal Article, 2014, DOI , TARA - Full Text
  • Conor Young, Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae, Trinity College Dublin, 2015Thesis, 2015
  • Young, Conor P and Hillyer, Cory and Hokamp, Karsten and Fitzpatrick, Darren J and Konstantinov, Nikifor K and Welty, Jacqueline S and Ness, Scott A and Werner-Washburne, Margaret and Fleming, Alastair B and Osley, Mary Ann, Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast, BMC genomics, 18, (1), 2017, p107Journal Article, 2017, DOI , URL
  • Michael Church, Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Trinity College Dublin, 2015Thesis, 2015
  • Church M, Smith KC, Alhussain MM, Pennings S, Fleming AB., Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene, Nucleic Acids Research, 45, (8), 2017, p4413 - 4430Journal Article, 2017, URL
  • Church MC, Fleming AB, A role for histone acetylation in regulating transcription elongation., Transcription, 2018Review Article, 2018, DOI
  • Kröger C, Schauer K, Clerkin S, Maertlbauer E and Fleming AB, Draft Genome Sequence and Annotation of Acinetobacter junii MHI21018, Isolated from Bovine Colostrum, Microbiology Resource Announcements, 2019Journal Article, 2019, DOI
  • Frawley D, Greco C, Oakley B, Alhussain MM, Fleming AB, Keller NP, Bayram Ö.Cell , The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus., Cellular Microbiology, 22, (6), 2020, p1-14Journal Article, 2020, DOI
  • Frawley D, Stroe MC, Oakley BR, Heinekamp T, Straßburger M, Fleming AB, Brakhage AA, Bayram Ö, The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus., Frontiers in Microbiology, 11, (811), 2020, p10.3389/fmicb.2020.00811Journal Article, 2020
  • Silva LP, Frawley D, Assis LJ, Tierney C, Fleming AB, Bayram O, Goldman GH, Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources., mSphere, 5, (5), 2020, p1-14Journal Article, 2020
  • Nicole Byrne, Investigating the interplay between the Tup1-Cyc8 and Swi-Snf chromatin remodelling complexes in Saccharomyces cerevisiae, University of Dublin, Trinity College Dublin, 2021Thesis, 2021
  • Mohamed Alhussain, Investigating chromatin remodelling by the Tup1-Cyc8 and Swi-Snf complexes in Saccharomyces cerevisiae, University of Dublin, Trinity College Dublin, 2020Thesis, 2020
  • Karahoda, B. and Pardeshi, L. and Ulas, M. and Dong, Z. and Shirgaonkar, N. and Guo, S. and Wang, F. and Tan, K. and Sarikaya-Bayram, Ã-. and Bauer, I. and Dowling, P. and Fleming, A.B. and Pfannenstiel, B.T. and Luciano-Rosario, D. and Berger, H. and Graessle, S. and Alhussain, M.M. and Strauss, J. and Keller, N.P. and Wong, K.H. and Bayram, Ã-., The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis, Nucleic acids research, 50, (17), 2022, p9797-9813Journal Article, 2022, DOI , URL
  • Barski, A. and Chepelev, I. and Liko, D. and Cuddapah, S. and Fleming, A.B. and Birch, J. and Cui, K. and White, R.J. and Zhao, K., Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes, Nature Structural and Molecular Biology, 17, (5), 2010, p629-634Journal Article, 2010, DOI , URL
  • Brenda Lee, Distinct phenotypes and transcriptomes of tup1 and cyc8 mutants suggest novel roles for TUP1 and CYC8 in Saccharomyces cerevisiae, Trinity College Dublin, 2023Thesis, 2023
  • Lee B, Church M, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB., Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex., PLoS genetics, 19, (8), 2023, pe1010876Journal Article, 2023, DOI
  • Karahoda B, Pfannenstiel BT, Sarikaya-Bayram Ö, Dong Z, Ho Wong K, Fleming AB, Keller NP, Bayram Ö., The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus., Fungal genetics and biology : FG & B, 169, 2023, p103836Journal Article, 2023, DOI
  • Pranay Agarwal, Investigating Tup1-Cyc8 complex function in Saccharomyces cerevisiae following the confirmation and characterization of a TUP1 conditional mutant, Trinity College Dublin, 2022Thesis, 2022
  • Patrícia Alves de Castro , Camila Figueiredo Pinzan , Thaila Fernanda Dos Reis , Clara Valero , Norman Van Rhijn , Carla Menegatti , Ivan Lucas de Freitas Migliorini , Michael Bromley , Alastair B Fleming , Aimee M Traynor , Özlem Sarikaya-Bayram , Özgür Bayram , Iran Malavazi , Frank Ebel , Júlio César Jerônimo Barbosa , Taícia Fill , Monica Tallarico Pupo , Gustavo H Goldman, Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection, Nature Communications, 15, (1), 2024, p1 - 18Journal Article, 2024, DOI , URL , TARA - Full Text
  • Lee B, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB., The influence of flocculation upon global gene transcription in a yeast CYC8 mutant, Microbial Genomics, 10, (1), 2024, p1 - 17Journal Article, 2024, URL
  • Artem Barski, Iouri Chepelev, Joanna Birch, Suresh Cuddapah, Alastair B. Fleming, Dritan Liko, Kairong Cui, Robert J. White and Keji Zhao, Pol II and its associated epigenetic marks co-localize throughout the genome with pol III-transcribed non-coding RNA genes, Nature Molecular & Structural Biology, 17, (5), 2010, p629-634Journal Article, 2010, DOI
  • Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA., H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, Molecular Cell, 31, (1), 2008, p57 - 66Journal Article, 2008, DOI
  • Alastair Fleming and Sari Pennings, Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene., Nucleic Acids Research, 35, (16), 2007, p5520 - 5531Journal Article, 2007, DOI , TARA - Full Text
  • Osley MA, Fleming AB, Kao CF., Histone ubiquitylation and the regulation of transcription., Results and Problems in Cell Differentiation, 41, (2006), 2007, p47 - 75Journal Article, 2007, DOI
  • Tsukuda T, Fleming AB, Nickoloff JA, Osley MA., Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae., Nature, 438, (7066), 2005, p379 - 383Journal Article, 2005, DOI
  • Fleming AB, Pennings S., Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation., Yeast, XXth YGM Conference, Prague, Czech Republic, August 26-31, 18, 2001, pp95 - 96Conference Paper, 2001, URL
  • Fleming A, Osley MA., Silence of the rings., Cell, 119, (4), 2004, p449 - 451Journal Article, 2004, DOI
  • Fleming AB, Tangney M, Jørgensen PL, Diderichsen B, Priest FG., Extracellular enzyme synthesis in a sporulation-deficient strain of Bacillus licheniformis., Applied and environmental microbiology, 61, (11), 1995, p3775 - 3780Journal Article, 1995, URL , TARA - Full Text
  • Fleming, A.B. and Pennings, S. , Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation, EMBO Journal, 20, (18), 2001, p5219 - 5230Journal Article, 2001, DOI
  • Tangney, M., Fleming, A.B., Jorgensen, and Priest, F.G, You have full text access to this OnlineOpen articleRegulation of maltose metabolism in stationary phase cultures of an asporogenous mutant of Bacillus licheniformis , Journal of Applied Microbiology, 84, (2), 1998, p201 - 206Journal Article, 1998, DOI
  • Shieh, G.S., Pan, C.-H., Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., (...), Kao, C.-F., H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast, BMC Genomics, 12, 2011, part. no. 627Journal Article, 2011, DOI , TARA - Full Text
  • Haran J, Boyle H, Hokamp K, Yeomans T, Liu Z, Church M, Fleming AB, Anderson MZ, Berman J, Myers LC, Sullivan DJ, Moran GP, Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits., PLoS genetics, 10, (10), 2014, pe1004658Journal Article, 2014, DOI , URL , TARA - Full Text
  • Alastair Fleming, The epigenetic landscape of quiescent yeast cells. , University of Maynooth, 13 Feb, 2015Invited Talk
  • Alastair Fleming, Conor Young, Cory Hillyer and Mary Ann Osley, The histone modification landscape of quiescent yeast cells formed during chronological aging, Keystone Conference in Cancer Epigenetics, Santa Fe, New Mexico, USA, 20-24 March, 2013Poster
  • Alastair Fleming, Chromatin remodelling during yeast stationary phase, University of Cork, 2012Invited Talk
  • Alastair Fleming, Ursula Bond, Gary Moran and Derek Sullivan, Irish Fungal Society Meeting, 11-12 June , 2015, Trinity College DublinMeetings /Conferences Organised
  • Michael Church and Alastair Fleming, Investigating FLO1 gene regulation by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Irish Fungal Society Meeting, NUI Galway, 19-20 June, 2014, Irish Fungal SocietyInvited Talk
  • Alastair Fleming, The epigenetic landscape of quiscent yeast cells, Irish Fungal Society Meeting, 11-12 June, 2015Invited Talk
  • Suzanne Beggs and Alastair Fleming, Investigating nucleosome dynamics during transcription elongation in Saccharomyces cerevisiae, EMBO Gene Transcription in Yeast, Sant Feliu de Guíxols, Spain, 14-19 June, 2014Poster
  • Alastair Fleming, Interplay between H2B ubiquitylation and histone chaperones during transcription, Scottish Chromatin Group, MRC, Edinburgh, UK, 24 th October, 2007, Scottish Chromatin GroupInvited Talk
  • Alastair Fleming, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, CMBS seminar series, University of St. Andrews, 10th September, 2007Invited Talk
  • Alastair Fleming, Different roles for H2B ubiquitylation and H3 methylation during gene transcription in yeast, Edinburgh Systems Biology Group Meeting, University of Edinburgh, 1 November, 2007Invited Talk
  • Fleming, A.B., Kao, C.K., Hillier, C., Pickaart, M. and Osley, M. A, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, FASEB, Chromatin and transcription, Snowmass, Colorado, USA, July 7th - 12th, 2007Poster
  • Cory Hillyer, Nikifor Konstantinov, Alastair B. Fleming, and Mary Ann Osley , Histone modification patterns during development of budding yeast stationary phase, Signalling to Chromatin, Cambridge, UK, 7th - 10th Sept 2010, edited by Wellcome Trust , 2010Poster

Recognition

  • Microbiology Society 2018