Dr. Conor Finlay
Senior Research Fellow, Trinity Translational Medicine Institute
Email cofinlay@tcd.ie Phone https://github.com/Conorisco/CVBiography
I started my career at Trinity College Dublin under Prof Kingston Mills, where I used pre-clinical models of autoimmunity to identify pathways that shut down inflammation. I focused on how anti-inflammatory `type 2" immune responses regulated the inflammatory `type 1" responses. My interest in type 2 immune responses and myeloid cells brought me to a world-leading macrophage lab at the University of Manchester, under Prof Judi Allen. In Manchester, I retrained in bioinformatics, enabling me to understand project delivery from a multi-disciplinary point of view. Most recently, I moved into translational research at the Trinity Translational Medicine Institute (TTMI) gaining skills in patient-focused research, including in clinical data analysis and study design and facilitating collaboration with clinician-scientitst.
Publications and Further Research Outputs
- Han Jichan, Gallerand Alexandr, Erlich Emma C, Helmink Beth A, Mair Iri, Li Xi, Eckhouse Shaina R, Dimou Francesca M, Shakhsheer Baddr A, Phelps Hannah M, Chan Mandy M, Mintz Rachel L, Lee Daniel D, Schilling Joel D, Finlay Conor M, Allen Judith E, Jakubzick Claudia V, Else Kathryn J, Onufer Emily J, Zhang Na, Randolph Gwendalyn J, Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species, Nature Immunology, 25, (1), 2024, p155 - 165Journal Article, 2024, DOI
- Ridge, Katie and Moran, Barry and Alvarado-Vazquez, P. Abigail and Hallgren, Jenny and Little, Mark A. and Irvine, Alan D. and O'Farrelly, Cliona and Dunne, Jean and co-senior). Finlay, Conor M (co-corresponding & and Conlon, Niall, Lin-CD117+CD34+FceRI+ progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti-IgE therapy, Allergy, In Press, 2024Journal Article, 2024
- Finlay, Conor M and Allen, Judith E, IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging., Immunity, 57, (3), 2024, p403--406Journal Article, 2024, DOI , URL
Research Expertise
I am a Cellular Immunologist and bioinformatician who combines molecular, in vivo and translational research. My main reserach interest is in the differentiation and function of monocnuclear phagocytes (monocytes, macrophages and dendritic cells) in tissues during inflammation. I am particularly interested in how classically inflammatory "Type 1" immune responses and anti-inflammatory "Type 2" immmune response affect the differentiation paths that macrophages take in tissues. To study these concepts in diseases of two organs, the Kidney and the pleural cavity. I have a long-term interests in cell-cell interactions during infection and autoimmunity, particularly in how T cells instuct myeloid cells like macrophages, neutrophils, eosinophils and mast cells.
Recognition
- Best presentation from selected abstracts - Irish Society of Immunology 2019
- Visiting student training scheme - Weizmann Institute of Science 2015
- Valdicotrian - Biochemistry with Immunology degree 2007