Medicine

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Trinity Biomedical Sciences Institute
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Professor Frances Duane

Professor Frances Duane

Clinical Associate Professor, Radiation Therapy

Biography

Professor Duane is a Consultant Radiation Oncologist at St. Luke's Radiation Oncology Network (SLRON), St. Luke's Hospital and St James's Hospital and a Clinical Associate Professor at Trinity College Dublin. She completed the Radiation Oncology National Training Programme in Ireland in 2014 and a 4-year Medical Research Council Clinical Oncology Research Fellowship in the UK. She holds a DPhil degree in breast cancer radiotherapy from the University of Oxford and her clinical research focuses on improving the quality of care received by patients with breast cancer. She is currently Co-Chair of the Breast Radiotherapy Group at the St. Luke's Radiation Oncology Network, Co-Chair of the Cancer Trials Ireland Breast Disease Specific Site Group, a member of the Cancer Trials Ireland Safety Monitoring Committee, a member of the National Cancer Control Programme Breast Radiotherapy Guidelines Group and Proton Therapy Group. She is also member of the Michael Moriarty Research Laboratory Scientific Committee at St. Luke's Hospital. She has a keen interest in medical education and enjoys supervising undergraduate and postgraduate students. She is currently Academic Teaching Lead for Radiation Oncology on the St. James's Hospital campus, the Radiation Oncology National Training Programme Co-Ordinator, RCSI and directs the St. Luke's Hospital Multidisciplinary Transition Year Programme at St. Luke's Hospital, Rathgar.

Publications and Further Research Outputs

  • Boekel NB*, Duane FK*, Jacobse JN, Hauptmann M, Schaapveld M, Sonke GS, Gietema JA, Hooning MJ, Seynaeve CM, Maas AHEM, Darby SC, Aleman BMP, van Leeuwen FE, Heart failure after treatment for breast cancer, Eur J Heart Fail, 22, 2020, p366 - 374Journal Article, 2020, DOI
  • Duane FK, McGale P, Teoh S, Mortimer C, Broggio J, Darby SC, Dodwell D, Lavery B, Oliveros S, Vallis KA, Taylor CW, International Variation in Criteria for Internal Mammary Chain Radiotherapy., Clin Oncol (R Coll of Radiol), 7, 2019, p453 - 461Journal Article, 2019, DOI
  • Duane FK, McGale P, Brønnum D, Cutter DJ, Darby SC, Ewertz M, Hackett S, Hall P, Lorenzen EL, Rahimi K, Wang Z, Warren S, Taylor CW, Cardiac Structure Doses in Women Irradiated for Breast Cancer in the Past and Their Use in Epidemiological Studies., Pract Rad Oncol, 9, 2019, p158 - 171Journal Article, 2019, DOI
  • Duane FK, Dodwell D, Chua BH, Axillary conservation in women with 1-2 sentinel node-positive breast cancer: Further research is needed, J Med Imaging Radiat Oncol, 63, 2018, p151 - 153Journal Article, 2018, DOI
  • Jacobse JN*, Duane FK*, Boekel NB, Schaapveld M, Hauptmann M, Hooning MJ, Seynaeve CM, Baaijens MHA, Gietema JA, Darby SC, van Leeuwen FE, Aleman BMP, Taylor CW, Radiation Dose-Response for Risk of Myocardial Infarction in Breast Cancer Survivors., Int J Radiat Oncol Biol Phys, 103, 2018, p595 - 604Journal Article, 2018, DOI
  • Boekel NB, Jacobse JN, Schaapveld M, Hooning MJ, Gietema JA, Duane FK, Taylor CW, Darby SC, Hauptmann M, Seynaeve CM, Baaijens MHA, Sonke GS, van Leeuwen FE, Cardiovascular disease incidence after internal mammary chain irradiation and anthracycline-based chemotherapy for breast cancer., Br J Cancer, 199, 2018, p408 - 418Journal Article, 2018, DOI
  • Taylor C, McGale P, Brønnum D, Correa C, Cutter D, Duane FK, Gigante B, Jensen MB, Lorenzen E, Rahimi K, Wang Z, Darby SC, Hall P, Ewertz M, Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study With Individual Patient Data., J Clin Oncol, 36, 2018, p2288 - 2296Journal Article, 2018, DOI
  • Aznar MC*, Duane FK*, Darby SC, Wang Z, Taylor CW, Exposure of the lungs in breast cancer radiotherapy: A systematic review of lung doses published 2010-2015, Radiother Oncol, 126, 2018, p148 - 154Journal Article, 2018, DOI , URL
  • Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials, J Clinical Oncol, 35, 2017, p1641 - 1649Journal Article, 2017, DOI
  • Duane F, Aznar MC, Bartlett F, Cutter DJ, Darby SC, Jagsi R, Lorenzen EL, McArdle O, McGale P, Myerson S, Rahimi K, Vivekanandan S, Warren S, Taylor CW, A cardiac contouring atlas for radiotherapy., Radiother Oncol, 122, 2017, p416 - 422Journal Article, 2017, DOI
  • Taylor CW, Wang Z, Macaulay E, Jagsi R, Duane F, Darby SC, Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013., Int J Radiat Oncol Biol Phys, 93, 2015, p845 - 853Journal Article, 2015, DOI
  • Duane F, McVeigh E, Dunne M, Faul C, McArdle O, Target coverage and brachial plexus dose in regional adjuvant radiotherapy for breast cancer., Radiother Oncol, ESTRO Forum, (106), 2013, ppS398Poster, 2013, DOI
  • Duane FK, Langan B, Gillham C, Walsh L, Rangaswamy G, Lyons C, Dunne M, Walker C, McArdle O, Impact of delineation uncertainties on dose to organs at risk in CT-guided intracavitary brachytherapy, Brachytherapy, 13, 2014, p210 - 218Journal Article, 2014, DOI
  • Skourou C, McVeigh E, Duane F, Murphy J, Dosimetric differences in forward planned IMRT calculated and delivered with dynamic fields or with multiple static subfields: a multimodality comparison. , Int J Radiat Oncol Biol Phys, ASTRO, 84, 2012, ppS777Poster, 2012, DOI
  • Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials, The Lancet, 383, 2014, p2127 - 2135Journal Article, 2014, DOI
  • D Dodwell and C Taylor and P McGale and C Coles and F Duane and R Gray and T Kühn and C Hennequin and S Oliveros and Y Wang and J Overgaard and P Poortmans and T Whelan, Abstract GS4-02: Regional lymph node irradiation in early stage breast cancer: An EBCTCG meta-analysis of 13,000 women in 14 trials, General Session Abstracts, 2019Journal Article, 2019, DOI
  • Monaghan O, O'Dwyer N, Dunne M, Nugent J, Coughlan N, Nolan A, Gilbert F, Glynn A, Duane F, Parkes C, Brennan S., Factors associated with feeding tube requirement in Oropharyngeal Cancer treated with IMRT, Radiotherapy and Oncology, 161, (Supplement, S802-S80), 2021Poster, 2021, DOI
  • Duane F*, Kerr A*, Wang Z, Darby S, Ntentas G, Aznar M, Taylor C., Exposure of the oesophagus in breast cancer radiotherapy: A systematic review of oesophagus doses published 2010-2020, Radiotherapy and Oncology, 164, 2021, p261 - 267Journal Article, 2021, DOI
  • Kerr A, Dodwell D, McGale P, Holt F, Duane F, Mannu G, Darby S, Taylor CW, Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality, Cancer Treatment Reviews, 105, (102375), 2022Journal Article, 2022, DOI
  • Kearney M, Keys M, Faivre-Finn C, Wang Z, Aznar MC, Duane F, Exposure of the Heart in Lung Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2013 to 2020, Radiotherapy and Oncology, 172, 2022, p118 - 125Journal Article, 2022, DOI
  • Frances K.Duane, Naomi B.Boekel, Judy N.Jacobse, ZheWang, Berthe M.P.Aleman, Sarah C.Darby, Michael Schaapveld, Flora E.van Leeuwen, Margreet H.A.Baaijens, SamanthaWarren, Carolyn W.Taylor, Exposure of the heart and cardiac valves in women irradiated for breast cancer 1970-2009, Clinical and Translational Radiation Oncology, 36, 2022, p132 - 139Journal Article, 2022, DOI
  • Nicholson J, Nugent K, Farmer G, Monaghan O, O Driscoll H, Cleary S, McArdle O*, Duane F*. , One-Year Toxicity of Ultrahypofractionated Breast Radiotherapy (+/- Sequential Boost) and a Survey of Patient Experience., International Journal of Radiation Oncology Biology Physics , ASTRO, San Antonio, Oct 2022, 114(3); e10, 2022Poster, 2022, DOI
  • K. Nugent, E. Quinlan, S. Cleary, H. O'Driscoll, C. Rohan, J. Trousdell, J. Williams, M. Dunne, O Mc Ardle*, F.K. Duane*, Implementation of 26 Gy in five fractions over 1 week adjuvant radiotherapy for breast cancer: Prospective report of acute skin toxicity and consideration of resource implications, The Breast , 67, 2023, p55-61-Journal Article, 2023, DOI , TARA - Full Text
  • O Houlihan*, G Ntentas*, DJ Cutter, P Daly, C Gillham, O McArdle*, FK Duane*, Predicted cardiac and second cancer risks for patients undergoing VMAT for mediastinal Hodgkin lymphoma, Clinical and Translational Oncology, 2023, p1368 - 1377Journal Article, 2023, DOI
  • Holt F, Probert J, Darby S, Haviland JS, Coles CE, Kirby AM, Liu Z, Dodwell D, Ntentas G, Duane F, Taylor C., Proton Beam Therapy for Early Breast Cancer: A Systematic Review and Meta-analysis of Clinical Outcomes., International Journal of Radiation Oncology* Biology* Physics., 117, (4), 2023, p869 - 882Journal Article, 2023, DOI
  • Wheeler, G., Grassberger, C., Samers, J., Dwyer, M Zacharin, M., Wiltshire, K., Daly, P., Alvarez, B., Campbell, B.A., Kerr, A.J., Kron, T., Duane, F.K, Zacharin M, Downey P, Kyriakou E, Ronkers CM, Constine L, Heniker S. , Central Endocrine Complications Among Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review, International Journal Radiation Oncology Biology Physics , 2023, pS0360-3016(23)00416-9Journal Article, 2023, DOI
  • B.K. Linderholm, A. Valachis, V. Gordon Flote, P. Poortmans, O. Kaidar Person, E. Niligal-Yam, S. O'Reilly, F. Duane, T. Marinko, M. Ekholm, A. Andersson, J. Bergqvist, T. Foukakis, M. Kadum, K. Kulbacka-Ortiz, A. Nilsson-Ek, L. Visani, D. Lundstedt, I. Meattini, Treatment of oligometastatic breast cancer (OMBC): A randomised phase III trial comparing stereotactic ablative radiotherapy (SABR) and systemic treatment with systemic treatment alone as first-line treatment - TAORMINA, ESMO Open, ESMO, 2023, pp1;8(1).Conference Paper, 2023, DOI
  • Guhan Rangaswamy, Jill Nicholson, Orla Monaghan, Neil Wallace, Daniel Foley, Christina Skourou, Fran Duane, Brian O'Neill, Pierre Thirion, Moya Cunningham, Sinead Brennan, Orla McArdle, Contouring Workshops - The Beneficial Impact on Radiation Oncology Specialist Training in Ireland, International Journal of Radiation Oncology, Biology, Physics, 116, (3), 2023, ppe8-e9Conference Paper, 2023
  • Gerard M Walls, John O'Connor, Mark Harbinson, Eamon P McCarron, Frances Duane, Conor McCann, Peter McKavanagh, David I Johnston, Jayaraj Erekkath, Valentina Giacometti, Anna T Gavin, Jonathan McAleese, Alan R Hounsell, Aidan J Cole, Karl T Butterworth, Conor K McGarry, Gerard G Hanna, Suneil Jain, Association between statin therapy dose intensity and radiation cardiotoxicity in non-small cell lung cancer: results from the NI-HEART study, Radiotherapy and Oncology , 2023Journal Article, 2023, DOI
  • Taylor, C., Dodwell, D., McGale, P., Hills, R., Berry, R., Bradley, R., Braybrooke, J., Clarke, M., Gray, R., Holt, F., Liu, Z., Pan, H., Peto, R., Straiton, E., Bergh, J., Coles, C., Duane, F., Hennequin, C., Jones, G., Kuhn, T,, Oliveros, S., Overgaard, J., Pritchard, K., Suk, C., Swain, S., Whelan, T., Poortmans P., Radiotherapy to regional lymph nodes in early breast cacner: an individual patient data meta-analysis of 14324 women in 16 trials., Lancet, 402, 2023, p1991 - 2003Journal Article, 2023, DOI
  • Walls GM, O'Connor J, Harbinson M, Duane F, McCann C, McKavanagh P, Johnston DI, Giacometti V, McAleese J, Hounsell AR, Cole AJ, Butterworth KT, McGarry CK, Hanna GG, Jain S., The Association of Incidental Radiation Dose to the Heart Base with Overall Survival and Cardiac Events after Curative-intent Radiotherapy for Non-small Cell Lung Cancer: Results from the NI-HEART Study, Clinical Oncology (R Coll Radiol), 36, (2), 2024, p119 - 127Journal Article, 2024, DOI
  • NCCP Breast Cancer Guideline Development Group (Radiation Oncology Subgroup), National Clinical Guideline Treatment of Patients with Breast Cancer: Radiation Oncology, National Cancer Control Programme, May, 2023Report, 2023
  • F Duane, A Flavin, C Faul, C Small, R Ryan, L Murphy, E O' Toole, NCCP advice for Medical Professionals on the management of patients undergoing Breast Cancer Radiotherapy in response to the current novel coronavirus (COVID-19) outbreak, HSE Reports - Cancer Services, April, 2020Report
  • Frances Duane, Breast Cancer Radiotherapy: Exposure of the Heart and Lungs, University of Oxford, 2019Thesis
  • F Duane, 'A Cardiac Contouring Atlas for Radiotherapy', eContour.org, 2019, -Software
  • Holt F, Ivanova A, Wang Z, Darby S, Duane F, Ntentas G, Oliveros S, Lavery B, Shah K, Eichholz A, Dodwell D, Taylor C., Estimated Doses to the heart, lungs and oesophagus and risks from typical UK radiotherapy for early breast cancre during 2015-2023., Clinical Oncology (RCR), Sep;36(9):e322-e332, 2024Journal Article, DOI
  • holtJournal Article

Research Expertise

Medical, health and life sciences, Cancer,