Professor Veronica Ann Campbell

• Endocannabinoids and Alzheimer's Disease in, editor(s)Liana Fattore , Cannabinoids in Neurologic and Mental Disease, Elsevier Academic Press, 2015, ppChapter 2 - [SG Fagan, VA Campbell]Book Chapter, 2015
• Xue, F. Lennon, A.B. McKayed, K.K. Campbell, V.A. Prendergast, P.J., Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells, Computer Methods in Biomechanics and Biomedical Engineering, 18, (5), 2015, p468 - 476Journal Article, 2015, DOI , URL , TARA - Full Text
• Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 54, (7), 2017, p5730 - 5739Journal Article, 2017, DOI , URL
• Darren S. D. Martin, Peter E. Lonergan, Barry Boland, Marie P. Fogarty, Marcella Brady, David F. Horrobin, Veronica A. Campbell, and Marina A. Lynch, Apoptotic changes in the aged brain are triggered by interleukin-1 beta-induced activation of P38 and reversed by treatment with eicosapentaenoic acid, Journal of Biological Chemistry, 277, (37), 2002, p34239 - 34246Journal Article, 2002, DOI , URL
• Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch, Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's immune modulation therapy, Neuroimmunomodulation, 10, (1), 2002, p40 - 46Journal Article, 2002, DOI , URL
• Campbell, Veronica; Lynch, Marina A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1[beta] in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, NEUROREPORT, 9, (9), 1998, p1923 - 1927Journal Article, 1998, URL
• Vereker E, Campbell V, Roche E, McEntee E, Lynch MA., Lipoplysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1, Journal of Biological Chemistry, 275, (34), 2000, p26252 - 26258Journal Article, 2000, DOI , URL
• V. A. Campbell, R. Segurado and M. A. Lynch, Regulation of intracellular Ca2+ concentration by interleukin-1â in rat cortical synaptosomes: an age-related study , Neurobiology of Aging, 19, (6), 1998, p575 - 579Journal Article, 1998, DOI , URL
• Prina_Mello, A, Farrell, E, Prendergast, PJ, Campbell, V, Coey, JMD, Effects of static magnetic fields on Primary cortical neurons, Physica Scripta, T118, 2005, p205 - 207Journal Article, 2005, DOI , URL
• Prina-Mello A., Farrell E., Prendergast P.J., Campbell V., Coey J.M.D. , Influence of Strong Static Magnetic Fields on Primary Cortical Neurons, Bioelectromagnetics, 27, (1), 2006, p35 - 42Journal Article, 2006, DOI , URL
• Veronica Campbell and Marina A. Lynch , The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1beta in rat cortical synaptosomes, Cytokine, 12, (5), 2000, p487 - 490Journal Article, 2000, DOI , URL
• Haugh O, Penman J, Irving AJ, Campbell VA., The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions., Curr Drug Targets, 17, (16), 2016, p1834 - 1840Journal Article, 2016
• McKayed K, Prendergast PJ, Campbell VA., Aging enhances the vulnerability of mesenchymal stromal cells to uniaxial tensile strain-induced apoptosis., Journal Biomechanics, 49, (3), 2016, p458 - 462Journal Article, 2016, DOI
• Boland, B. and Campbell, V. , Aß-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L., Neurobiology of Aging , 25, (1), 2004, p83 - 91Journal Article, 2004, DOI
• Downer E., Fogarty M.P. and Campbell, V.A , Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons , British Journal of Pharmacology , 140, (3), 2003, p547 - 557Journal Article, 2003, URL
• Fogarty, M.P., Downer, E. and Campbell, V. , Characterisation of the role of JNK isoforms in ß-amyloid-mediated p53 activation and apoptosis. , Biochemical Journal , 371, 2003, p779 - 789Journal Article, 2003
• Boland, B and Campbell, V, beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase., Neurobiology of Aging , 24, (1), 2003, p179 - 186Journal Article, 2003, URL
• MacManus A., Ramsden, M., Murray M., Pearson H.A and Campbell V , ) Enhancement of 45Ca2+ influx and voltage-dependent Ca2+ channel activity by ß-amyloid(1-40) in rat cortical synaptosomes and cultured cortical neurones: modulation by the proinflammatory cytokine interleukin-1ß, Journal of Biological Chemistry , 275, 2000, p4713 - 4718Journal Article, 2000, URL
• Campbell, V.A., Tetrahydrocannabinol-induced apoptosis in cultured cortical neurons is associated with cytochrome c release and caspase-3 activation, Neuropharmacology , 40, (5), 2001, p702 - 709Journal Article, 2001, DOI , URL
• Scaffolds and cells: preliminary biomechanical analysis and results for the use of a collagen-GAG scaffold for bone tissue engineering in, editor(s)P.J Prendergast & P.E McHugh , Topics in Bio-Mechanical Engineering, Dublin, TCBE & NCBES, 2004, pp167 - 183, [F.J. O'Brien, E. Farrell, M.A. Waller, I. Connell, D. O'Mahoney, J.P. McGarry, B.P. Murphy, P.E. McHugh, V.A. Campbell, P.J. Prendergast ]Book Chapter, 2004
• Minogue, A.M., Schmid, A.W., Fogarty, M.F., Moore, A.C., Campbell, V.A. and Herron, C.E., Activation of the JNK signalling cascade mediates the effect of A beta on LTP and cell death in hippocampus: a role for IL-1 beta, J. Biol. Chem., 278, (30), 2003, p27971 - 27980Journal Article, 2003, DOI , URL
• Nolan, Y., Martin, D.S.D., Campbell, V.A., and Lynch, M.A., Evidence of a protective effect of phosphatidylserine on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus, J. Neuroimmunol., 151, (Issues 1-2,), 2004, p12-23Journal Article, 2004, DOI , URL
• Nolan Y, Campbell VA, Bolton AE, Lynch MA, Evidence of an anti-inflammatory role for Vasogen's immune modulation therapy, Neuroimmunomodulation, 12, (2), 2005, p113 - 116Journal Article, 2005, DOI , URL
• Campbell, V., Beddy, P., Foley, A., Bakhle, Y.S. and Bell, C, Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK1 receptor number. , European Journal of Pharmacology , 401, (1), 2000, p109 - 114Journal Article, 2000, DOI
• Campbell, V. and Lynch, M.A , The role of ceramide in the interleukin-1ß-mediated modulation of [Ca2+]i in rat cortical synaptosomes., Cytokine, 12, (5), 2000, p487 - 490Journal Article, 2000, DOI
• Campbell, V. and Lynch, M.A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1ß in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, Neuroreport , 9, (9), 1998, p1923 - 1927Journal Article, 1998, URL
• Wyatt, C.N., Campbell, V., Page, K.M., Berrow, N.S., Terracciano, C.M., Naqvi, N., MacLeod, K.T. and Dolphin A.C, Voltage-dependent binding and calcium channel current inhibition by an anti-?1D subunit antibody in rat dorsal root ganglion neurones and guinea-pig myocytes, Journal of Physiology, 502, (2), 1997, p307 - 320Journal Article, 1997, DOI
• Brice, N.L., Berrow, N.S., Campbell, V., Page, K.M., Tedder, I. and Dolphin, A.C , Importance of the different beta subunits in the membrane expression of the alpha1A and alpha2 calcium channel subunits: studies using a depolarization-sensitive alpha1A antibody., European Journal of Neuroscience , 9, (4), 1997, p749 - 759Journal Article, 1997
• Campbell, V., Berrow, N.S., Brickley, K,. Page, K.M., Wade, R. and Dolphin, A.C , Voltage-dependent calcium channel ß-subunits, in combination with ?1-subunits, have a GTPase activating effect to promote the hydrolysis of GTP by G?o in rat frontal cortex., FEBS Letters , 370, (1-2), 1995, p135 - 140Journal Article, 1995, DOI
• Campbell, V., Berrow, N.S., Fitzgerald, E., Brickley, K. and Dolphin, A., Inhibition of the interaction of G protein Go with calcium channels by the calcium channel ß-subunit in rat sensory neurones., Journal of Physiology , 485, (2), 1995, p365 - 372Journal Article, 1995, DOI
• Brickley, K., Campbell, V., Berrow, N., Leach, R., Norman, R.I., Wray, D. and Dolphin, A.C. , Use of site-directed antibodies to probe the topology of the ?2-subunit of the voltage-dependent Ca2+ channel. , FEBS Letters , 364, (2), 1995, p129 - 133Journal Article, 1995, DOI
• Berrow, N.S., Campbell, V., Fitzgerald, E.M., Brickley, K. and Dolphin, A.C , Antisense depletion of the ß-subunits modulates the biophysical and pharmacological properties of neuronal calcium channels., Journal of Physiology , 482, (3), 1995, p481 - 491Journal Article, 1995, URL
• Pearson, H.A., Campbell, V., Berrow, N., Menon-Johansson, A. and Dolphin, A.C., Modulation of voltage dependent calcium channels in cultured neurons, Annals of the New York Academy of Sciences, 747, 1994, p325 - 335Journal Article, 1994
• Campbell, V., Berrow, N. S. and Dolphin, A.C., GABAB receptor modulation of Ca2+ currents in rat sensory neurones by the G protein Go: antisense oligonucleotide studies, Journal of Physiology , 470, 1993, p1 - 11Journal Article, 1993, URL
• Modulation of voltage-dependent calcium channels by GABA receptors and G-proteins in cultured rat dorsal root ganglion neurons: relevance to transmitter release and its modulation. in, editor(s)Urban, L , Cellular Mechanisms of Sensory Transmission, Berlin, Springer-Verlag, 1994, pp47 - 61, [Dolphin, A.C., Menon-Johansson, A. Campbell, V., Berrow, N.and Sweeney, M.I ]Book Chapter, 1994
• Prina_Mello A. , Campbell V., and Coey J.M.D. , Static magnetic field effect in cells. A possible roa to cell differentiation., NSTI Nanotech 2005 , Anaheim, CA, May 2005, edited by NSTI , NSTI, 2005Conference Paper, 2005
• E. Farrell., F.J. O'Brien., P. Doyle., J. Fischer., I. Yannas., B. O'Connell., P.J. Prendergast & V.A. Campbell , A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes., Tissue Engineering, 12, (3), 2006, p459 - 468Journal Article, 2006, DOI , URL
• Prina-Mello A, Farrell E, Prendergast PJ, Campbell V, Coey JMD , Influence of strong static magnetic fields on primary cortical neurons , Bioelectromechanics, 27, 1, (Jan), 2006, p35 - 42Journal Article, 2006, DOI
• Lynch AM, Walsh C, Delaney A, Nolan Y, Campbell VA, Lynch MA , Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?, Journal of Neurochemistry, 88, (3), 2004, p635 - 646Journal Article, 2004, DOI , URL
• Prendergast PJ, Kelly DJ, McMahon LA, Campbell VA, A computational optimisation of scaffolds for tissue engineering of cartilage, Tissue Engineering, 12, (4), 2006, p1024 - 1024Journal Article, 2006, DOI
• Gowran AM, Campbell VA, Molecular mechanisms of cannabinoid-induced neurotoxicity in rat cortical neurons, European Neuropsychopharmacology, 16, (Suppl. 1), 2006, pS26 - S27Journal Article, 2006
• McCormack, R. M., Fogarty, M. P., Campbell, V. A., Beta-amyloid modulates the lysosomal system in rat cortical neurons in vitro in a p53-dependent manner, Journal of Anatomy, 205, (6), 2004, p531-532Journal Article, 2004, URL
• Farrell, E., O'Brien, F., Prendergast, P. J., Campbell, V. A., Mesenchymal stem cells and bioengineering, Journal of Anatomy, 205, (6), 2004, p504 - 536Journal Article, 2004, URL
• Farrell, E, Byrne, EM, Fischer, J, O'Brien, FJ, O'Connell, BC, Prendergast, PJ, Campbell, VA, A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds., Technology and Healthcare, 15, (1), 2007, p19 - 31Journal Article, 2007, URL , TARA - Full Text
• Downer EJ, Gowran A, Murphy AC, Campbell VA., The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Delta(9)-tetrahydrocannabinol in cultured cortical neurons, European Journal of Pharmacology , 564, (1-3), 2007, p57 - 65Journal Article, 2007, DOI
• McGarry, JG, Maguire, P, Prendergast, PJ, Campbell, VA, O'Connell, BC, Jarvis, SP, Stimulation of nitric oxide mechanotransduction in single osteoblasts using atomic force microscopy, Journal of Orthopaedic Research, 26, (4), 2008, p513 - 521Journal Article, 2008, DOI , URL
• Maguire P, Kilpatrick JI, Kelly G, Prendergast PJ, Campbell VA, O'Connell BC, Jarvis SP, Direct mechanical measurement of geodesic structures in rat meseenchymal stem cells, Human Frontiers Science Program Journal, 1, (3), 2007, p181 - 191Journal Article, 2007, DOI , URL
• Campbell VA, Gowran A., Alzheimer's disease; taking the edge off with cannabinoids?, British Journal Pharmacology, 152, (5), 2007, p655 - 662Journal Article, 2007, DOI
• Downer EJ, Gowran A, Campbell VA., A comparison of the apoptotic effect of Delta(9)-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex., Brain Research, 1175, (1), 2007, p39 - 47Journal Article, 2007, DOI
• Gowran A, Campbell VA., A role for p53 in the regulation of lysosomal permeability by Delta(9)-tetrahydrocannabinol in rat cortical neurones; implications for neurodegeneration., Journal of Neurochemistry, 105, (4), 2008, p1513 - 1524Journal Article, 2008, DOI
• Cannabinoids and Neuroprotection in, editor(s)Attila Kofalvi , Cannabinoids and the Brain, Springer, 2008, pp317 - 330, [Veronica Campbell, Eric Downer]Book Chapter, 2008
• Kanichai M, Ferguson D, Prendergast PJ, Campbell VA, Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxia-inducible factor (HIF)-1, Journal of Cellular Physiology, 216, (3), 2008, p708 - 715Journal Article, 2008, DOI
• McMahon, L.A. , Prendergast, P.J. , Campbell, V.A., A comparison of the involvement of p38, ERK1/2 and PI3K in growth factor-induced chondrogenic differentiation of mesenchymal stem cells, Biochemical and Biophysical Research Communications , 368, (4), 2008, p990 - 995Journal Article, 2008, DOI , URL
• McMahon, L.A., Reid, A.J., Campbell, V.A. & Prendergast, P.J. , Regulatory Effects of Mechanical Strain on the Chondrogenic Differentiation of MSCs in a Collagen-GAG Scaffold: Experimental and Computational Analysis , Annals of Biomedical Engineering, 36, (2), 2008, p185-194Journal Article, 2008, DOI , URL
• P. Maguire, J.I. Kilpatrick, G. Kelly, P.J. Prendergast, V.A. Campbell, B.C. O'Connell and S.P. Jarvis, Direct mechanical measurement of geodesic structures in rat mesenchymal stem cells', Human Frontiers Science Program Journal, 1, (3), 2007, 181-191Journal Article, 2007, DOI , URL
• J.G. McGarry, P. Maguire, P.J. Prendergast, V.A. Campbell, B.C. O'Connell and S.P. Jarvis, Stimulating Nitric Oxide response in single osteoblasts using atomic force microscopy', Journal of Orthopaedic Research, 26, (4), 2008, p513-520Journal Article, 2008, DOI , URL
• Thorpe, S. D., Buckley, C. T., Vinardell, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 337, (2), 2008, p458-462Journal Article, 2008, DOI , URL , TARA - Full Text
• Prendergast, P.J., Kelly, D.J., McMahon, L.A., Campbell, V.A. , A computational optimization of scaffolds for tissue engineering of cartilage., Tissue Engineering, Abstracts of 8th TESI Annual Meeting 2005, Shanghai, China, October 22-25, 12, 2006, pp1024Meeting Abstract, 2006
• Fogarty MP, McCormack, RM, Noonan J, Murphy D, Gowran A, Campbell VA, A role for p53 in the ß-amyloid-mediated regulation of the lysosomal system, Neurobiology of Ageing, 583, (21), 2009, p3412-3418Journal Article, 2009, DOI
• Kearney M, Prendergast PJ, Campbell VA, Mechanisms of strain-mediated mesenchymal stem cell apoptosis, Journal of Biomechanical Engineering, 130, (6), 2008, pArticle number 061004Journal Article, 2008, DOI
• Byrne, E.M., Farrell, E., McMahon, L.A., Haugh, M.G., O'Brien, F.J., Campbell, V.A., Prendergast, P.J., O'Connell, B.C., Gene expression by marrow stromal cells in a porous collagen- glycosaminoglycan scaffold is affected by pore size and mechanical stimulation , Journal of Materials Science: Materials in Medicine, 19, (11-12), 2008, p3455-3463Journal Article, 2008, DOI
• McMahon, L.A., Campbell, V.A., Prendergast, P.J., Involvement of stretch-activated ion channels in strain-regulated glycosaminoglycan synthesis in mesenchymal stem cell-seeded 3D scaffolds , Journal of Biomechanics, 41, (9), 2008, p2055-2059Journal Article, 2008, DOI
• Marie P. Fogarty, Eric J. Downer and Veronica Campbell, A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the b-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons, Biochemical Journal, 371, 2003, p789-798Journal Article, 2003, DOI
• Gowran, A., Murphy, C.E., Campbell, V.A., Corrigendum to "Δ9-Tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain" [FEBS Lett. 583 (2009) 3412-3418] (DOI:10.1016/j.febslet.2009.09.056), 2010, - 239Miscellaneous, 2010, DOI
• Anderson, D.G., Campbell, V.A., Forsyth, G.A., Rankin, D.W.H., Determination of the molecular structures of bis(methylsilyl) sulphide and bis(dimethylsilyl) sulphide in the gas phase by electron diffraction, supported by molecular mechanics calculations, Journal of the Chemical Society, Dalton Transactions, 7, 1990, p2125-2130Journal Article, 1990, DOI
• Cellular & Molecular Biomechanics. in, editor(s)T. Clive Lee, Peter F. Niederer , Engineering for Medics and Biologists - An ESEM Primer: Studies in health technology and informatics, Online, IOP Press Online, 2010, pp202-213 , [Campbell VA, O'Connell B]Book Chapter, 2010, URL
• Kearney EM, Farrell E, Prendergast PJ, Campbell VA, Tensile strain as a regulator of mesenchymal stem cell osteogenesis., Annals of Biomedical Engineering, 38, (5), 2010, p1767-1779Journal Article, 2010, DOI
• Downer, EJ & Campbell VA, Phytocannabinoids, CNS cells and development; a dead issue?, Drug & Alcohol Review, 29, (1), 2010, p91 - 98Journal Article, 2010, DOI
• Campbell VA, O'Connell B, Cellular and molecular biomechanics., Technology and health care , 18, (3), 2010, p233-243Journal Article, 2010, DOI
• Thorpe, S. D., Buckley, C. T., Vinardel, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , The response of bone marrow derived mesenchymal stem cells to dynamic compression following TGF-â3 induced chondrogenic differentiation, Annals of Biomedical Engineering , 38, (9), 2010, p2896-2909Journal Article, 2010, DOI
• Aoife Gowran, Katey McKayed, Manoj Kanichai, Cillian White, Nissrin Hammadi and Veronica Campbell, Tissue Engineering of Cartilage; Can Cannabinoids Help?, Pharmaceuticals, 3, (9), 2010, p2970-2985Journal Article, 2010, DOI , URL , TARA - Full Text
• Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic Compression Post TGF-â3 Induced Differentiation Augments Chondrogenesis of Mesenchymal Stem Cells., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010Meeting Abstract, 2010
• Fogarty, M.P., McCormack, R.M., Noonan, J., Murphy, D., Gowran, A., Campbell, V.A. , A role for p53 in the â-amyloid-mediated regulation of the lysosomal system , Neurobiology of Aging , 31, (10), 2010, p1774-1786Journal Article, 2010, DOI
• Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic compression of mesenchymal stem cells following cytokine induced differentiation augments glycosaminoglycan synthesis., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April, 2010Meeting Abstract, 2010
• Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA, The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats., Journal of Biological Chemistry, 287(41), (41), 2012, p34709 - 34721Journal Article, 2012, DOI
• Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation, Journal of Neuroinflammation, 9, (79), 2012Journal Article, 2012, DOI
• Noonan J, Tanveer R, Klompas A, Gowran A, McKiernan J, Campbell VA., Endocannabinoids prevent β-amyloid-mediated lysosomal destabilization in cultured neurons., Journal of Biological Chemistry, 285, (49), 2010, p38543 - 38554Journal Article, 2010, DOI
• Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation., Journal of neuroinflammation, 9, 2012, p79Journal Article, 2012, DOI , TARA - Full Text
• Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA, The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-ß and in the cortex of aged rats., The Journal of biological chemistry, 287, (41), 2012, p34709-21Journal Article, 2012, DOI
• Gowran A, McKayed K, Campbell VA, The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health., Stem cells international, 2013, 2013, p796715Journal Article, 2013, DOI , TARA - Full Text
• Fagan SG, Campbell VA., The influence of cannabinoids on generic traits of neurodegeneration, British Journal of Pharmacology, 171, (6), 2014, p1347 - 1360Journal Article, 2014

Cannabinoid neuropharmacology; ß-amyloid; Neurodegeneration; Regulation of neuronal calcium homeostasis; Tissue engineering of bone and cartilage; Mesenchymal stem cells

• Title

  Investigation into the role of lysosomes in neuronal cell death
  Summary

  Alzheimer's disease is a devastating neurodegenerative condition which is associated with cognitive decline and neuronal loss. A neuropathological hallmark of this disease is the deposition of ß-amyloid (Aß) protein around neurons, and Aß is thought to contribute to the disease process by inducing neuronal cell death. We have identified that Aß increases intracellular Ca2+ concentration in cortical neurons (MacManus et al., 2000), leading to activation of Ca2+-dependent proteases and subsequent cell death (Boland et al., 2003). Understanding how Aß influences intracellular Ca2+ homeostasis is one of our key research questions given that dysregulation of this ion provides the basis for the "calcium hypothesis of neurodegeneration". Lysosomes are relatively understudied organelles that serve as reservoirs for Ca2+. Our recent work has demonstrated that Aß impacts on the lysosomal system, causing lysosomes to become leaky and release lysosomal proteases which then contribute to the cell death cascade (Boland et al., 2004). Events which cause the lysosomal membrane to become leaky are likely to promote the release of lysosomal Ca2+, as well as proteolytic enzymes, and contribute to the increase in intracellular Ca2+ concentration which is associated with many forms of cell death. We are currently attempting to examine the influence of Aß on lysosomal Ca2+ homeostasis since this may contribute to the induction of apoptosis that we observe following exposure of neurons to Aß in vitro .
  Funding Agency

  Enterprise Ireland
  Date From

  2003
  Date To

  2006
• Title

  Cannabinoids and neuronal fate
  Summary

  Marijuana is the most commonly used illegal drug of abuse in Ireland, particularly amongst the 14-16 year old age group. ?9-tetrahydrocannabinol (THC) is the psychoactive ingredient of marijuana and this project is concerned with furthering our understanding of the impact of THC on the brain.
  Funding Agency

  Science Foundation Ireland
  Date From

  2004
  Date To

  2007
• Title

  Effect of hypoxia on tissue engineering of bone and cartilage
  Summary

  This interdisciplinary project aims to identify the optimal conditions for inducing differentiation of adult mesenchymal stem cells along the osteogenic and chondrogenic lineages. The study will identify the signal transduction pathways involved in these processes.
  Funding Agency

  Health Research Board
  Date From

  2005
  Date To

  2008
• Title

  Cannabinoids and mesenchymal stem cell differentiation
  Summary

  The aim of this project is to examine the role of cannabinoid pathways in the control of bone and cartilage development.
  Funding Agency

  Science Foundation Ireland
  Date From

  October 2007
  Date To

  September 2009
• Title

  Do cannabinoids confer neuroprotection by stabilizing lysosomes?
  Summary
  Funding Agency

  Health Research Board
  Date From

  2009
  Date To

  2011

• Fellow of TCD 2004

• Member, Society for Neuroscience
• President, Royal Academy of Medicine in Ireland (Biomedical Sciences Section)
• Member, Physiological Society
• Secretary, Biomedical Sciences Section (Royal Academy Medicine in Ireland) 2007
• Editor, British Journal of Pharmacology
• Fellow, Royal Academy Medicine in Ireland