Medicine

Contact Us School of Medicine
Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

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medadmin@tcd.ie
Professor Michael Rowan

Professor Michael Rowan

Fellow Emeritus, Pharmacology & Therapeutics

Fellow Emeritus

http://people.tcd.ie/mrowan

Publications and Further Research Outputs

  • O'Malley, T.T. Oktaviani, N.A. Zhang, D. Lomakin, A. O'Nuallain, B. Linse, S. Benedek, G.B. Rowan, M.J. Mulder, F.A.A. Walsh, D.M., Aß dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies, Biochemical Journal, 461, (3), 2014, p413 - 426Journal Article, 2014, DOI , URL
  • Welzel, A.T. Maggio, J.E. Shankar, G.M. Walker, D.E. Ostaszewski, B.L. Li, S. Klyubin, I. Rowan, M.J. Seubert, P. Walsh, D.M. Selkoe, D.J., Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity, Biochemistry, 53, (24), 2014, p3908 - 3921Journal Article, 2014, DOI , URL , TARA - Full Text
  • Hu, N.-W. Nicoll, A.J. Zhang, D. Mably, A.J. O'Malley, T. Purro, S.A. Terry, C. Collinge, J. Walsh, D.M. Rowan, M.J., MGlu5 receptors and cellular prion protein mediate amyloid-ß- facilitated synaptic long-term depression in vivo, Nature Communications, 5, 2014Journal Article, 2014, DOI , URL , TARA - Full Text
  • Klyubin, I. Nicoll, A.J. Khalili-Shirazi, A. Farmer, M. Canning, S. Mably, A. Linehan, J. Brown, A. Wakeling, M. Brandner, S. Walsh, D.M. Rowan, M.J. Collinge, J., Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity, Journal of Neuroscience, 34, (18), 2014, p6140 - 6145Journal Article, 2014, DOI , URL , TARA - Full Text
  • Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang Y, Rowan M.J, Anwyl R, Han Y, Wang Q, Protection against ß-amyloid-induced synaptic and memory impairments via altering ß-amyloid assembly by bis(heptyl)-cognitin, Scientific Reports, 5, 2015, p10256-Journal Article, 2015, DOI , URL , TARA - Full Text
  • Levites Y, O-Nuallain B, Puligedda R.D, Ondrejcak T, Adekar S.P, Chen C, Cruz P.E, Rosario A.M, Macy S, Mably A.J, Walsh D.M, Vidal R, Solomon A, Brown D, Rowan M.J, Golde T.E, Dessain S.K, A human monoclonal IgG that binds Aß assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo, Journal of Neuroscience, 35, (16), 2015, p6265 - 6276Journal Article, 2015, DOI , URL
  • Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms., The Journal of biological chemistry, 290, (47), 2015, p28343 - 28352Journal Article, 2015, DOI , TARA - Full Text
  • Miller, A.M., Begley, E., Coen, R.F., Doyle, M., Dunne, J., Hutchinson, S., Kennelly, S.P., Kenny, R.A., Killeen, R.P., O'Dwyer, S., O'Neill, C., O'Sullivan, S.S., Rowan, M.J., Sheehy, N., McGuigan, C., Lawlor, B.A. , Clinical consensus guidelines on the application of cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: recommendations of the Irish Network for Biomarkers in Neurodegeneration., Irish Medical Journal, 109, (10), 2016, p1-13Journal Article, 2016, URL
  • Zhang D, Jin B, Ondrejcak T, Rowan M.J, Opposite in vivo effects of agents that stimulate or inhibit the glutamate/cysteine exchanger system xcâ, ' on the inhibition of hippocampal LTP by AÃ , Hippocampus, 26, (12), 2016, p1655 - 1665Journal Article, 2016, DOI , URL
  • McGahon B, Holscher C, McGlinchey L, Rowan MJ, Lynch MA., Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus., Learning and Memory, 3, (4), 1997, p296 - 304Journal Article, 1997, DOI , URL
  • Zhang, D. and Qi, Y. and Klyubin, I. and Ondrejcak, T. and Sarell, C.J. and Cuello, A.C. and Collinge, J. and Rowan, M.J., Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal studies, Neuropharmacology, 121, 2017, p231-246Journal Article, 2017, DOI , URL
  • Zhang, D. and Mably, A.J. and Walsh, D.M. and Rowan, M.J., Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- A nd TNFα-Mediated Synaptic Plasticity Disruption in the Rat Hippocampus, Cerebral Cortex, 27, (7), 2017, p3724-3735Journal Article, 2017, DOI , URL
  • Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms, Journal of Biological Chemistry, 290, (47), 2015, p28343 - 28352Journal Article, 2015, URL
  • O'Riordan KJ, Hu NW, Rowan MJ, Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo, Scientific Reports, 8, (1), 2018, p4391Journal Article, 2018, DOI , TARA - Full Text
  • Balschun, D. and Rowan, M.J., Hippocampal synaptic plasticity in neurodegenerative diseases: AÃ , tau and beyond, Neuroforum, 2018Journal Article, 2018, DOI , URL
  • Qi, Y. and Klyubin, I. and Claudio Cuello, A. and Rowan, M.J., NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo, Neurobiology of Disease, 114, 2018, p24-30Journal Article, 2018, DOI , URL
  • Hu NW, Corbett GT, Moore S, Klyubin I, O"Malley TT, Walsh DM, Livesey FJ, Rowan MJ, Extracellular forms of Aß and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity, Cell Reports, 23, (7), 2018, p1932-1938Journal Article, 2018, DOI , TARA - Full Text
  • O'Riordan, K.J. and Hu, N.-W. and Rowan, M.J., AÃ Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus, Cell Reports, 22, (8), 2018, p2094-2106Journal Article, 2018, DOI , URL , TARA - Full Text
  • Ondrejcak T, Hu N.-W, Qi Y, Klyubin I, Corbett G.T, Fraser G, Perkinton M.S, Walsh D.M, Billinton A, Rowan M.J, Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo, Neurobiology of Disease, 127, 2019, p582 - 590Journal Article, 2019, DOI
  • Ondrejcak T, Klyubin I, Corbett G.T, Fraser G, Hong W, Mably A.J, Gardener M, Hammersley J, Perkinton M.S, Billinton A, Walsh D.M, Rowan M.J, Cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau in vivo, Journal of Neuroscience, 38, (50), 2018, p10595 - 10606Journal Article, 2018, DOI , URL
  • O'Riordan K.J, Hu N.-W, Rowan M.J, AÃ Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus, Cell Reports, 22, (8), 2018, p2053 - 2065Journal Article, 2018, DOI , URL
  • Hu Z, Yu P, Zhang Y, Yang Y, Zhu M, Qin S, Xu JT, Duan D, Wu Y, Wang D, Rowan MJ and Hu NW, Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease, Translational Psychiatry, 12, (1), 2022Journal Article, 2022, DOI
  • Qi Y, Klyubin I, Ondrejcak T, Hu NW, Rowan Mj, Enduring glucocorticoid-evoked exacerbation of synaptic plasticity disruption in male rats modelling early Alzheimer's disease amyloidosis, Neuropsychopharmacology, 46, (12), 2021, p2170 - 2179Journal Article, 2021, DOI
  • Sosulina, L. and Mittag, M. and Geis, H.-R. and Hoffmann, K. and Klyubin, I. and Qi, Y. and Steffen, J. and Friedrichs, D. and Henneberg, N. and Fuhrmann, F. and Justus, D. and Keppler, K. and Cuello, A.C. and Rowan, M.J. and Fuhrmann, M. and Remy, S., Hippocampal hyperactivity in a rat model of Alzheimer†s disease, Journal of Neurochemistry, 157, (6), 2021, p2128-2144Journal Article, 2021, DOI , URL
  • Babiloni, C. and Blinowska, K. and Bonanni, L. and Cichocki, A. and De Haan, W. and Del Percio, C. and Dubois, B. and Escudero, J. and Fernández, A. and Frisoni, G. and Guntekin, B. and Hajos, M. and Hampel, H. and Ifeachor, E. and Kilborn, K. and Kumar, S. and Johnsen, K. and Johannsson, M. and Jeong, J. and LeBeau, F. and Lizio, R. and Lopes da Silva, F. and Maestú, F. and McGeown, W.J. and McKeith, I. and Moretti, D.V. and Nobili, F. and Olichney, J. and Onofrj, M. and Palop, J.J. and Rowan, M. and Stocchi, F. and Struzik, Z.M. and Tanila, H. and Teipel, S. and Taylor, J.P. and WeiergrÀber, M. and Yener, G. and Young-Pearse, T. and Drinkenburg, W.H. and Randall, F., What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons, Neurobiology of Aging, 85, 2020, p58-73Journal Article, 2020, DOI , URL
  • Qi, Y. and Klyubin, I. and Hu, N.-W. and Ondrejcak, T. and Rowan, M.J., Pre-plaque Aß-Mediated Impairment of Synaptic Depotentiation in a Transgenic Rat Model of Alzheimer's Disease Amyloidosis, Frontiers in Neuroscience, 13, (861), 2019Journal Article, 2019, DOI
  • Yin Yang, Tomas Ondrejcak, Neng-Wei Hu, Sadia Islam, Eugene O'Rourke, Richard Reilly, Colm Cunningham, Michael Rowan, Igor Klyubin, Gamma-patterned sensory stimulation reverses synaptic plasticity deficits in rat models of early Alzheimer's disease, European Journal of Neuroscience, 58, (6), 2023, p3402 - 3411Journal Article, 2023, DOI
  • O'Connor, J. J., Rowan, M. J. and Anwyl, R. , Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation, Nature, 367, (6463), 1994, p557 - 559Journal Article, 1994, DOI
  • Xu, L., Anwyl, R. and Rowan, M. J. , Behavioural stress facilitates the induction of long-term depression in the hippocampus, Nature, 387, 1997, p497 - 500Journal Article, 1997, DOI
  • Xu, L., Anwyl, R. and Rowan, M. J. , Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus, Nature, 394, 1998, p891 - 894Journal Article, 1998, DOI
  • Kim, J. H., Anwyl, R., Suh, Y. H., Djamgoz, M. B. and Rowan, M. J. , Use-dependent effects of amyloidogenic fragments of ß-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo, Journal of Neuroscience , 21, (4), 2001, p1327 - 1333.Journal Article, 2001, URL
  • Walsh, D. M., IKlyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J. and Selkoe, D. J. , Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416, (6880), 2002, p535 - 539.Journal Article, 2002, DOI
  • Li, S., Cullen, W. K., Anwyl, R. and Rowan, M. J., Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty, Nature Neuroscience, 6, 2003, p526 - 531Journal Article, 2003, DOI
  • Zhang Y, Yang Y, Hu Z, Zhu M, Qin S, Yu P, Li B, Xu J, Ondrejcak T, Klyubin I and Rowan MJ, Hu NW, Long-term depression-inducing low frequency stimulation enhances p-Tau181 and p-Tau217 in an age-dependent manner in live rats, Journal of Alzheimer's Disease, 89, (1), 2022, p335--350Journal Article, 2022, DOI
  • Klyubin I, Ondrejcak T, Hu NW, Rowan MJ, Glucocorticoids, synaptic plasticity and Alzheimer's disease, Current Opinion in Endocrine and Metabolic Research, 25, 2022, p100365Journal Article, 2022, DOI
  • Ondrejcak T, Klyubin I, Hu NW, O'Malley TT, Corbett GT, Winters R, Perkinton MS, Billinton A, Prenderville JA, Walsh DM, Rowan MJ, Tau and amyloid ß protein in patient-derived aqueous brain extracts act concomitantly to disrupt LTP in vivo, The Journal of Neuroscience, 43, (32), 2023, p5870--5879Journal Article, 2023, DOI
  • Hu Z, Ondrejcak T, Yu P, Zhang Y, Yang Y, Klyubin I, Rowan MJ, Kennelly SP, Hu NW, Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease?, Neural Regeneration Research, 18, (6), 2023, p1213-1219Journal Article, 2023, DOI
  • O'Riordan KJ, Hu NW, Rowan MJ, Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus., Cell reports, 22, (8), 2018, p2053 - 2065Journal Article, 2018, DOI
  • Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ, mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo, Nature communications, 4, (5), 2014, p3374Journal Article, 2014, DOI
  • Ondrejcak T, Klyubin I, Hu NW, Yang Y, Zhang Q, Rodriguez BJ and Rowan MJ, Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins, Philosophical Transactions of the Royal Society B, (379), 2024, p20230234Journal Article, 2024, DOI
  • Neng-Wei Hu, Tomas Ondrejcak, Igor Klyubin, Yin Yang, Dominic M. Walsh, Frederick J. Livesey, and Michael J. Rowan, Patient-derived tau and amyloid-ß facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response, Brain Communications, 2024, p10.1093/braincomms/fcae333Journal Article, 2024, DOI , TARA - Full Text
  • Harney SC, Rowan MJ and Anwyl R, Long-Term Depression of NMDA receptor-mediated synaptic transmission is dependent upon activation of mGluR5 and is altered to LTP by low intracellular calcium buffering, Journal of Neuroscience, 26, (4), 2006, p1128 - 1132Journal Article, 2006, DOI
  • Wang Q, Wu J, Rowan MJ and Anwyl R , Beta-amyloid inhibition of LTP is mediated via tumor necrosis factor, European Journal of Neuroscience, 22, (11), 2005, p2827 - 2832Journal Article, 2005, DOI
  • Rowan MJ, Klyubin I, Wang Q, Anwyl R., Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies, Biochemical Society Transactions, 33, (Part 4), 2005, p563 - 567Journal Article, 2005, URL
  • Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ., Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo, Nature Medicine, 11, (5), 2005, p556 - 561Journal Article, 2005, DOI
  • Rowan MJ, Klyubin I, Wang Q, Anwyl R., Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity, Experimental Gerontology, 39, (11-12), 2004, p1661 - 1667Journal Article, 2004, DOI
  • Ovsepian SV, Anwyl R, Rowan MJ., Endogenous acetylcholine lowers the threshold for long-term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study, European Journal of Neuroscience, 20, (5), 2004, p1267 - 1275Journal Article, 2004, DOI
  • Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ , Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo, European Journal of Neuroscience, 19, (10), 2004, p2839 - 2846Journal Article, 2004, DOI
  • Wang Q, Rowan MJ, Anwyl R, Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide, The Journal of Neuroscience, 24, (27), 2004, p6049 - 6056Journal Article, 2004, DOI , TARA - Full Text
  • Wang Q, Walsh DM, Rowan MJ, Selkoe DJ and Anwyl R , Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid {beta}-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5, Journal of Neuroscience, 24, (13), 2004, p3370 - 3378Journal Article, 2004, DOI
  • Wu J., Rush AM, Rowan MJ and Anwyl R, Synaptically stimulated induction of group I metabotropic glutamate receptor-dependent long-term depression and depotentiation is inhibited by prior activation of metabotropic glutamate receptors and protein kinase C , Neuroscience, 123, (2), 2004, p507 - 514Journal Article, 2004, DOI
  • Wu J, Rowan MJ and Anwyl R., An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro, Neuropharmacology, 46, (3), 2004, p311 - 317Journal Article, 2004, DOI
  • Rowan MJ, Klyubin I, Cullen WK, Anwyl R., Synaptic plasticity in animal models of early Alzheimer's disease, Philosophical Transactions of the Royal Society B: Biological Sciences, 358, (1432), 2003, p821 - 828Journal Article, 2003, DOI
  • Gisabella B, Rowan MJ, Anwyl R., Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro, Neuroscience , 121, (2), 2003, p297 - 305Journal Article, 2003, DOI
  • Li S, Cullen WK, Anwyl R and Rowan MJ , Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty, Nature Neuroscience, 6, (5), 2003, p526 - 531Journal Article, 2003, DOI
  • N. A. Breakwell, M. J. Rowan, and R. Anwyl , (+)-MCPG Blocks Induction of LTP in CA1 of Rat Hippocampus via Agonist Action at an mGluR Group II Receptor , Journal of Neurophysiology, 79, (3), 1998, p1270 - 1276Journal Article, 1998, URL
  • Wang Y, Rowan MJ, Anwyl R., (RS)-alpha-Methyl-4-carboxyphenylglycine inhibits long-term potentiation only following the application of low frequency stimulation in the rat dentate gyrus in-vitro, Neuroscience Letters, 197, (3), 1995, p207 - 210Journal Article, 1995
  • W.L. Lee, R. Anwyl and M. Rowan, 4-aminopyridine-mediated increase in long-term potentiation in CA1 of the rat hippocampus, Neuroscience Letters, 70, (1), 1986, p106 - 109Journal Article, 1986, DOI
  • Manahan-Vaughan D, Anwyl R, Rowan MJ., 5-HT1A receptor-mediated inhibition in the hippocampus of the alert rat--effects of repeated gepirone treatment., European Journal of Pharmacology, 260, (2-3), 1994, p149 - 155Journal Article, 1994, DOI
  • C Hölscher, L McGlinchey, R Anwyl, and M J Rowan, 7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat., Learning & Memory, 2, 1996, p267 - 278Journal Article, 1996, DOI
  • S. Li, R. Anwyl, M. J. Rowan, A persistent reduction in short-term facilitation accompanies long-term potentiation in the CA1 area in the intact hippocampus, Neuroscience, 100, (2), 2000, p213 - 220Journal Article, 2000, DOI
  • O'Connor JJ, Rowan MJ, Anwyl R., Actions of 5-HT1 ligands on excitatory synaptic transmission in the hippocampus of alert rats., British Journal of Pharmacology, 101, (1), 1990, p171 - 177Journal Article, 1990, URL
  • A. M. Rush, J. Wu, M. J. Rowan, R. Anwyl, Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus, Neuroscience, 105, (2), 2001, p335 - 341Journal Article, 2001, DOI
  • Christian Hölscher, Roger Anwyl and Michael J. Rowan, Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo, European Journal of Pharmacology, 322, (2-3), 1997, p155 - 163Journal Article, 1997, DOI
  • Rush AM, Wu J, Rowan MJ and Anwyl, R, Group I Metabotropic Glutamate Receptor (mGluR)-Dependent Long-Term Depression Mediated via p38 Mitogen-Activated Protein Kinase Is Inhibited by Previous High-Frequency Stimulation and Activation of mGluRs and Protein Kinase C in the Rat Dentate Gyrus In Vitro , Journal of Neuroscience , 22, (12), 2002, p6121 - 6128Journal Article, 2002, URL
  • Shakesby AC, Anwyl R and Rowan MJ , Overcoming the effects of stress on synaptic plasticity in the intact hippocampus:rapid action of serotonergic and antidepressant agents, Journal of Neuroscience , 22, (9), 2002, p3638 - 3644Journal Article, 2002, URL
  • Walsh DM Klyubin I, Fadeeva JV, Cullen WK, Wolfe MS, Anwyl R, Rowan MJ and Selkoe DJ, Naturally secreted oligomers of the Alzheimers amyloid B-protein inhibit hippocampal long-term potentiation in vivo, Nature, 416, 2002, p535 - 539Journal Article, 2002, DOI
  • Carney R, Dardis C, Cullen WK, Felipo V, Anwyl R, Rowan MJ, Early spatial memory deficit induced by 2,5-hexanedione in the rat., Toxicology Letters, Mar 10, 128, (1-3), 2002, p107 - 115Journal Article, 2002, DOI
  • Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ, The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention., Biochemical Society Transactions , 33, (5), 2005, p1087 - 1090Journal Article, 2005, URL
  • Chang L, Wang Q, Wu J, Rowan M, Anwyl R, Investigation of the mechanisms underlying Group I-mediated LTD in the dentate gyrus, 1826, 2005, -Miscellaneous, 2005, DOI
  • Wang Q, Harney S, Wu J, Rowan M, Anwyl R, Role of group I mGluRs in the beta-amyloid inhibition of LTP, 1826, 2005, -Miscellaneous, 2005, DOI
  • Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang LY, Anwyl R, Selkoe DJ, Rowan MJ, Natural, cell-derived Aβ oligomers: their production, biological activity and inhibition , 1826, 2004, -Miscellaneous, 2004, URL
  • Klyubin I, Walsh DM, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ, Anti-Aβ antibodies prevention block of long-term potentiation in the CA1 area of rat hippocampus in vivo by naturally produced Aβ oligomers , 1826, 2004, -Miscellaneous, 2004, URL
  • Kotilinek LA, Wang QW, Westerman MA, Lim GP, Falinska A, Simonyi A, Younkin LH, Younkin SG, Sun GY, Rowan M, Cleary J, Frautschy SA, Cole GM, Anwyl R, Ashe KH, NSAIDs improve amyloid beta protein-induced deficits in memory and synaptic plasticity, 1826, 2004, -Miscellaneous, 2004, DOI
  • Wu J, Rowan MJ, Anwyl R, Long-term potentiation is mediated by multiple kinase cascades involving CaMKII or either PKA or p42/44 MAPK in the adult rat dentate gyrus in vitro, Journal of Neurophysiology, 95, (6), 2006, p3519 - 3527Journal Article, 2006, DOI
  • O'Reilly MA, Cunningham CJ, Lawlor BA, Walsh CD, Rowan MJ, The effect of the menstrual cycle on electrophysiological and behavioral measures of memory and mood, Psychophysiology, 41, (4), 2004, p592 - 603Journal Article, 2004, DOI
  • Klyubin, I, Wang, Q, Reed, MN, Irving, EA, Upton, N, Hofmeister, J, Cleary, JP, Anwyl, R, Rowan, MJ, Protection against Abeta-mediated rapid disruption of synaptic plasticity and memory by memantine., Neurobiology of Aging, 32, 2011, p614 - 633Journal Article, 2011, DOI
  • Welsby, PJ, Rowan, MJ, Anwyl, R, Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus., The European Journal of Neuroscience, 29, (1), 2009, p65-75Journal Article, 2009, DOI
  • Ryan, B, Musazzi, L, Mallei, A, Tardito, D, Gruber, SH, El Khoury, A, Anwyl, R, Racagni, G, Mathé, AA, Rowan, MJ, Popoli, M, Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression., International Journal of Neuropsychopharmacology, 12, (4), 2009, p553-559Journal Article, 2009, DOI , URL , TARA - Full Text
  • Hu, NW, Smith, IM, Walsh, DM, Rowan, MJ, Soluble amyloid-ß peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo, Brain, 131, (9), 2008, p2414 - 2424Journal Article, 2008, DOI
  • Ryan, BK, Anwyl, R, Rowan, MJ, 5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress., Neuropharmacology, 55, (2), 2008, p175-182Journal Article, 2008, DOI
  • Shankar, GM, Li, S, Mehta, TH, Garcia-Munoz, A, Shepardson, NE, Smith, I, Brett, FM, Farrell, MA, Rowan, MJ, Lemere, CA, Regan, CM, Walsh, DM, Sabatini, BL, Selkoe, DJ, Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory., Nature Medicine, 14, (8), 2008, p837-842Journal Article, 2008, DOI , URL , TARA - Full Text
  • Wang, Q.-W., Rowan, M.J., Anwyl, R., Inhibition of LTP by beta-amyloid is prevented by activation of β2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway , Neurobiology of Aging, 30, (10), 2009, p1608-1613Journal Article, 2009, DOI
  • Ondrejcak T, Klyubin I, Hu NW, Barry AE, Cullen WK, Rowan MJ, Alzheimer's disease amyloid ß-protein and synaptic function, NeuroMolecular Medicine, 12, (1), 2010, p13 - 26Journal Article, 2010, DOI
  • Wang, Q., Klyubin, I., Wright, S., Griswold-Prenner, I., Rowan, M.J., Anwyl, R., αv integrins mediate beta-amyloid induced inhibition of long-term potentiation , Neurobiology of Aging , 29, (10), 2008, p1485-1493Journal Article, 2008, DOI
  • Wu, J., Harney, S., Rowan, M.J., Anwyl, R., Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro , Neuroscience Letters, 436, (2), 2008, p235-238Journal Article, 2008, DOI , URL
  • Kotilinek, L.A., Westerman, M.A., Wang, Q., Panizzon, K., Lim, G.P., Simonyi, A., Lesne, S., Agnieszka Falinska, Linda H. Younkin, Steven G. Younkin, Michael Rowan, James Cleary, Roi Ann Wallis, Grace Y. Sun, Greg Cole, Sally Frautschy, Roger Anwyl and Ashe, K.H., Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity , Brain , 131, (3), 2008, p651-664Journal Article, 2008, DOI , URL , TARA - Full Text
  • Hayes, J., Li, S., Anwyl, R., Rowan, M.J., A role for protein kinase A and protein kinase Mζ in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo, Neuroscience , 151, (2), 2008, p604-612Journal Article, 2008, DOI
  • Amico, F., Spowart-Manning, L., Anwyl, R., Rowan, M.J., Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat , European Journal of Pharmacology , 577, (1-3), 2007, p71-77Journal Article, 2007, DOI
  • Rowan, M.J., Klyubin, I., Wang, Q., Hu, N.W., Anwyl, R., Synaptic memory mechanisms: Alzheimer's disease amyloid ß-peptide-induced dysfunction, Biochemical Society Transactions, 35, (5), 2007, p1219-1223Journal Article, 2007, DOI
  • Welsby, P.J., Rowan, M.J., Anwyl, R., Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP , Neuropharmacology , 53, (1), 2007, p188-195Journal Article, 2007, DOI
  • Li, S., Cullen, W.K., Anwyl, R., Rowan, M.J., Muscarinic acetylcholine receptor-dependent induction of persistent synaptic enhancement in rat hippocampus in vivo , Neuroscience, 144, (2), 2007, p754-761Journal Article, 2007, DOI
  • Wang, Q., Chang, L., Rowan, M.J., Anwyl, R., evelopmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus , Neuroscience, 144, (1), 2007, p110-118Journal Article, 2007, DOI
  • Welsby, P., Rowan, M., Anwyl, R., Nicotinic receptor-mediated enhancement of long-term potentiation involves activation of metabotropic glutamate receptors and ryanodine-sensitive calcium stores in the dentate gyrus , European Journal of Neuroscience , 24, (11), 2006, p3109-3118Journal Article, 2006, DOI
  • Cooke, S.F., Wu, J., Plattner, F., Errington, M., Rowan, M., Peters, M., Hirano, A., Karl D. Bradshaw, Roger Anwyl, Timothy V. P. Bliss and Giese, K.P., Autophosphorylation of αCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse , Journal of Physiology , 574, (3), 2006, p805-818Journal Article, 2006, DOI
  • Salami, M., Rowan, M.J., Dose dependent effect of memantine on long-term potentiation in the CA1 area of the hippocampus , Yakhteh , 8, (29), 2006, p17-22+65Journal Article, 2006
  • Hu NW, Klyubin I, Anwyl R, Rowan MJ, GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo, Proceedings of the National Academy of Sciences of the United States of America, 106, (48), 2009, p20504 - 20509Journal Article, 2009, TARA - Full Text
  • Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ, Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization., The Journal of Neuroscience, 28, (16), 2008, p4231-7Journal Article, 2008, DOI , URL , TARA - Full Text
  • Anwyl, R., Rowan, M.J., Neurophysiological evidence for tricyclic antidepressant-induced decreased beta-adrenergic responsiveness in the rat hippocampus , Brain Research, 300, (1), 1984, p192-194Journal Article, 1984, DOI
  • Rowan, M.J., Anwyl, R., The effect of prolonged treatment with tricyclic antidepressants on the actions of 5-hydroxytryptamine in the hippocampal slice of the rat, Neuropharmacology, 24, (2), 1985, p131-137Journal Article, 1985, DOI
  • Anwyl, R., Rowan, M.J., Frequency-dependent block of field potentials in the rat hippocampal slice caused by tricyclic antidepressants, British Journal of Pharmacology, 86, (1), 1985, p201-208Journal Article, 1985, URL
  • Rowan, M.J., Anwyl, R., Neurophysiological effects of buspirone and isapirone in the hippocampus: Comparison with 5-hydroxytryptamine, European Journal of Pharmacology, 132, (1), 1986, p93-96Journal Article, 1986, DOI
  • Lee WL, Anwyl R, Rowan M., Caffeine inhibits post-tetanic potentiation but does not alter long-term potentiation in the rat hippocampal slice, Brain Research, 426, (2), 1987, p250-256Journal Article, 1987, DOI
  • Anwyl, R., Walshe, J., Rowan, M., Electroconvulsive treatment reduces long-term potentiation in rat hippocampus , Brain Research , 435, (1-2), 1987, p377-379Journal Article, 1987, DOI
  • Rowan, M.J., O'Conner, J.J., Anwyl, R., Changes in auditory evoked responses and in the inhibitory action of 5-hydroxytryptophan following chronic treatment with imipramine in the rat , Psychopharmacology , 96, (3), 1988, p408-413Journal Article, 1988, DOI
  • Mulkeen, D., Anwyl, R., Rowan, M., The effects of external calcium on long-term potentiation in the rat hippocampal slice , Brain Research, 447, (2), 1988, p234-238Journal Article, 1988, DOI
  • Anwyl, R., Lee, W.-L., Rowan, M., The role of calcium in short-term potentiation in the rat hippocampal slice , Brain Research , 459, (1), 1988, p192-195Journal Article, 1988, DOI
  • Anwyl, R., Mulkeen, D., Rowan, M.J., The role of N-methyl-D-aspartate receptors in the generation of short-term potentiation in the rat hippocampus , Brain Research, 503, (1), 1989, p148-151Journal Article, 1989, DOI
  • John J. O'Connor, Michael J. Rowan and Roger Anwyl, Serotonergic involvement in the inhibitory effects of repeated buspirone treatment on synaptic transmission in the hippocampus, European Journal of Pharmacology, 167, (1), 1989, p21-29Journal Article, 1989, DOI
  • McGuinness, N., Anwyl, R., Rowan, M, The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice, NeuroReport, 2, (11), 1991, p688-690Journal Article, 1991
  • McGuinness, N., Anwyl, R., Rowan, M., Trans-ACPD enhances long-term potentiation in the hippocampus, European Journal of Pharmacology, 197, (2-3), 1991, p231-232Journal Article, 1991, DOI
  • McGuinness, N., Anwyl, R., Rowan, M., The effects of external calcium on the N-methyl-D-aspartate induced short-term potentiation in the rat hippocampal slice, Neuroscience Letters, 131, (1), 1991, p13-16Journal Article, 1991, DOI
  • McGuinness, N., Anwyl, R., Rowan, M., Inhibition of an N-methyl-D-aspartate induced short-term potentiation in the rat hippocampal slice, Brain Research, 562, (2), 1991, p335-338Journal Article, 1991, DOI
  • McGuinness, N., Anwyl, R., Rowan, M.J., Enhancement of long-term potentiation by an agonist of the metabotropic glutamate receptor in the rat hippocampal slice , Journal of Physiology, 446, 1992, p442PJournal Article, 1992
  • O'Connor, J.J., Rowan, M.J., Anwyl, R, Serotoninergic depression of auditory evoked responses recorded in the rat hippocampus: Effect of repeated buspirone treatment, Brain Research, 573, (2), 1992, p190-196Journal Article, 1992, DOI
  • O'Connor, J.J., Rowan, M.J., Anwyl, R., Erratum: Serotoningergic depression of auditory evoked responses recorded in the rat hippocampus: Effect of repeated buspirone treatment (Brain Research, 573 (1992) (190-196)), 1992, - 179Miscellaneous, 1992, DOI
  • O'Connor, J.J., Rowan, M.J., Anwyl, R., Use-dependent effects of acute and chronic treatment with imipramine and buspirone on excitatory synaptic transmission in the rat hippocampus in vivo, Naunyn-Schmiedeberg's Archives of Pharmacology, 348, (2), 1993, p158-163Journal Article, 1993
  • O'Connor, J.J., Rowan, M.J., Anwyl, R, Potentiation of the isolated NMDA receptor-mediated excitatory postsynaptic current following metabotropic glutamate receptor activation and tetanic stimulation in rat hippocampal cells, Journal of Physiology, 473, 1993, 47PJournal Article, 1993
  • O'Connor, J.J., Rowan, M.J., Anwyl, R, Long-lasting potentiation of the NMDA receptor-mediated EPSC is inhibited by metabotropic glutamate receptor antagonists in rat dentate granule cells in vitro, Journal of Physiology, 473, 1993, p170PJournal Article, 1993
  • Manahan-Vaughan, D., Anwyl, R., Rowan, M.J., Adaptive changes in 5-HT(1A) receptor-mediated hippocampal inhibition in the alert rat produced by repeated 8-OH-DPAT treatment, British Journal of Pharmacology, 112, (4), 1994, p1083-1088Journal Article, 1994
  • Wu, J., Anwyl, R., Rowan, M.J., β-amyloid-(1-40) increases long-term potentiation in rat hippocampus, European Journal of Pharmacology, 284, (3), 1995, pR1-R3Journal Article, 1995, DOI
  • O'Connor, J.J., Rowan, M.J., Anwyl, R, Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current: Investigations of the involvement of mGlu receptors, Journal of Neuroscience, 15, (3), 1995, p2013-2020Journal Article, 1995, URL
  • O'Mara, S.M., Rowan, M.J., Anwyl, R., Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus, Neuroscience, 68, (3), 1995, p621-624Journal Article, 1995, DOI
  • O'Mara, S.M., Rowan, M.J., Anwyl, R., Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro, Neuropharmacology, 34, (8), 1995, p983-989Journal Article, 1995, DOI
  • O'Connor, J.J., Wu, J., Rowan, M.J, Anwyl, R., Potentiation of N-methyl-D-aspartate-receptor-mediated currents detected using the excised patch technique in the hippocampal dentate gyrus, Neuroscience, 69, (2), 1995, p363-369Journal Article, 1995, DOI
  • Wu, J., Anwyl, R., Rowan, M.J., β-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus, NeuroReport, 6, (17), 1995, p2409-2413Journal Article, 1995
  • Manahan-Vaughan, D., Anwyl, R., Rowan, M.J, The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT(1A) receptor, European Journal of Pharmacology, 294, (2-3), 1995, p617-624Journal Article, 1995, DOI
  • Doyle, C., Hölscher, C., Rowan, M.J., Anwyl, R, The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo, Journal of Neuroscience, 16, (1), 1996, p418-424Journal Article, 1996, URL
  • Wang, Y, Wu, J., Rowan, M.J., Anwyl, R., Ryanodine produces a low frequency stimulation-induced NMDA receptor-independent long-term potentiation in the rat dentate gyrus in vitro, Journal of Physiology, 495, (3), 1996, p755-767Journal Article, 1996, URL
  • Breakwell, N.A., Rowan, M.J., Anwyl, R., Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area Ca1 of the submerged rat hippocampal slice, Journal of Neurophysiology, 76, (5), 1996, p3126-3135Journal Article, 1996, URL
  • Doyle, C.A., Cullen, W.K., Rowan, M.J., Anwyl, R, Low-frequency stimulation induces homosynaptic depotentiation but not long-term depression of synaptic transmission in the adult anaesthetized and awake rat hippocampus in vivo, Neuroscience, 77, (1), 1997, p75-85Journal Article, 1997, DOI
  • Wang, Y, Rowan, M.J., Anwyl, R., Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores, Journal of Neurophysiology, 77, (2), 1997, p812-825Journal Article, 1997, URL
  • Wu, J., Wang, Y., Rowan, M.J., Anwyl, R, Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro, Neuroscience, 78, (2), 1997, p393-398Journal Article, 1997, DOI
  • Breakwell, N.A., Huang, L., Rowan, M.J., Anwyl, R., DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus, European Journal of Pharmacology, 322, (2-3), 1997, p173-178Journal Article, 1997, DOI
  • Xu, L, Anwyl, R., De Vry, J., Rowan, M.J., Effect of repeated ipsapirone treatment on hippocampal excitatory synaptic transmission in the freely behaving rat: Role of 5-HT(1A) receptors and relationship to anxiolytic effect, European Journal of Pharmacology, 323, (1), 1997, p59-68Journal Article, 1997, DOI
  • Huang, L., Rowan, M.J., Anwyl, R., mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD induction, in the dentate gyrus in vitro, NeuroReport, 8, (3), 1997, 687-693Journal Article, 1997, URL
  • Hölscher, C., McGlinchey, L., Anwyl, R. Rowan, M.J., HFS-induced long-term potentiation of LFS-induced depotentiation in area CA1 of the hippocampus are not good models for learning, Psychopharmacology, 130, (2), 1997, p174-182Journal Article, 1997, DOI
  • Hölscher, C., Anwyl, R., Rowan, M., Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD: Further evidence against LTP as a model for learning, NeuroReport, 8, (2), 1997, p451-454Journal Article, 1997, URL
  • Cullen, W.K., Wu, J., Anwyl, R., Rowan, M.J., β-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus, NeuroReport, 8, (1), 1997, p87-92Journal Article, 1997, URL
  • Huang, L, Breakwell, N.A., Rowan, M.J., Anwyl, R., PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro, European Journal of Pharmacology, 332, (2), 1997, p161-165Journal Article, 1997, DOI
  • Hölscher, C., Anwyl, R., Rowan, M.J., Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can be depotentiated by stimulation on the negative phase in area CA1 in vivo, Journal of Neuroscience, 17, (16), 1997, p6470-6477Journal Article, 1997, URL
  • Hölscher, C., Anwyl, R., Rowan, M.J., Block of theta-burst-induced long-term potentiation by (1S,3S)-1- aminocyclopentane-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning, Neuroscience, 81, (1), 1997, p17-22Journal Article, 1997, DOI
  • Wang Y, Wu J, Rowan MJ, Anwyl R., Conditions for the induction of long-term potentiation and long-term depression by conjunctive pairing in the dentate gyrus in vitro, Journal of Neurophysiology, 78, (5), 1997, p2569-2573Journal Article, 1997, URL
  • Wang, Y., Rowan, M.J., Anwyl, R, LTP induction dependent on activation of Ni2+-sensitive voltage-gated calcium channels, but not NMDA receptors, in the rat dentate gyrus in vitro, Journal of Neurophysiology, 78, (5), 1997, p2574-2581Journal Article, 1997, URL
  • Cullen, William K.; Suh, Yoo-Hun; Anwyl, Roger; Rowan, Michael J, Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments, NeuroReport, 8, (15), 1997, p3213-3217Journal Article, 1997, URL
  • Xu, L., Holscher, C., Anwyl, R., Rowan, M.J., Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress, Proceedings of the National Academy of Sciences of the United States of America, 95, (6), 1998, p3204-3208Journal Article, 1998, DOI
  • Wu, J., Wang, Y., Rowan, M.J., Anwyl, R., Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro, Journal of Neuroscience, 18, (10), 1998, p3589-3596Journal Article, 1998, URL
  • Kilbride, J., Huang, L, Rowan, M.J., Anwyl, R., Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV, European Journal of Pharmacology, 356, (2-3), 1998, 149-157Journal Article, 1998, DOI
  • Camodeca, N., Rowan, M.J., Anwyl, R., Induction of LTD by increasing extracellular Ca2+ from a low level in the dentate gyrus in vitro, Neuroscience Letters, 255, (1), 1998, p53-56Journal Article, 1998, DOI
  • Rowan MJ, Anwyl R, Xu L., Stress and long-term synaptic depression, Molecular Psychiatry, 3, (6), 1998, p472-474Journal Article, 1998, URL
  • Wang, Y., Wu, J., Rowan, M.J., Anwyl, R., Role of protein kinase C in the induction of homosynaptic long-term depression by brief low frequency stimulation in the dentate gyrus of the rat hippocampus in vitro, Journal of Physiology, 513, (2), 1998, p467-475Journal Article, 1998, DOI
  • Breakwell, N.A., Rowan, M.J., Anwyl, R., Erratum: (+)-MCPG blocks induction of LTP in CA 1 of rat hippocampus via agonist action at an mGluR group II receptor (Journal of Neurophysiology (March 1998) 79 (1270-1276)), 1999, - 12Miscellaneous, 1999
  • Huang, L., Killbride, J., Rowan, M.J., Anwyl, R, Activation of mGluRII induces LTD via activation of protein kinase A and protein kinase C in the dentate gyrus of the hippocampus in vitro, Neuropharmacology, 38, (1), 1999, p73-83Journal Article, 1999, DOI
  • Huang, L., Rowan, M.J., Anwyl, R., Induction of long-lasting depression by (+)-α-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro, European Journal of Pharmacology, 366, (2-3), 1999, p151-158Journal Article, 1999, DOI
  • Camodeca, N., Breakwell, N.A., Rowan, M.J., Anwyl, R, Induction of LTD by activation of group I mGluR in the dentate gyrus in vitro, Neuropharmacology, 38, (10), 1999, p1597-1606Journal Article, 1999, DOI
  • Huang, L.-Q., Rowan, M.J., Anwyl, R., Role of protein kinases A and C in the induction of mGluR-dependent long-term depression in the medial perforant path of the rat dentate gyrus in vitro, Neuroscience Letters, 274, (2), 1999, p71-74Journal Article, 1999, DOI
  • Breakwell, N.A. Rowan, M.J., Anwyl, R., Erratum: (+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor (Journal of Neurophysiology (March 1998) 79 (1270-1276)), 1999, - xiiMiscellaneous, 1999
  • Breakwell, N.A., Huang, L.Q., Rowan, M.J., Anwyl, R, Erratum: DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus (European Journal of Pharmacology (1997) 322 (173-178) PII: S0014299997000150), 2000, - 85Miscellaneous, 2000, DOI
  • Rush, A.M., Rowan, M.J, Anwyl, R., Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro, Neuroscience Letters, 298, (3), 2001, p175-178Journal Article, 2001, DOI
  • Wu, J, Rush, A, Rowan, M.J., Anwyl, R., MDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro, Journal of Physiology, 533, (3), 2001, p745-755Journal Article, 2001, DOI
  • Kilbride, J., Rush, A.M., Rowan, M.J., Anwyl, R., Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro, Journal of Neurophysiology, 85, (6), 2001, p2509-2515Journal Article, 2001, URL
  • Rush, A.M., Kilbride, J., Rowan, M.J., Anwyl, R., Presynaptic group III mGluR modulation of short-term plasticity in the lateral perforant path of the dentate gyrus in vitro, Brain Research, 952, (1), 2002, p38-43Journal Article, 2002, DOI
  • Lanté F, Toledo-Salas JC, Ondrejcak T, Rowan MJ, Ulrich D, Removal of Synaptic Ca2+-Permeable AMPA Receptors during Sleep., The Journal of Neuroscience , 31, (11), 2011, p3953-61Journal Article, 2011, DOI , URL , TARA - Full Text
  • Hu NW, Ondrejcak T, Rowan MJ, Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances, Pharmacology Biochemistry and Behavior, 100, (4), 2012, p855 - 862Journal Article, 2012, TARA - Full Text
  • Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J, Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites., Nature Communications, 2, (336), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
  • Barry, A.E., Klyubin, I., McDonald, J.M., Mably, A.J., Farrell, M.A., Scott, M., Walsh, D.M., Rowan, M.J., Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP In Vivo is prevented by immunotargeting cellular prion protein, Journal of Neuroscience, 31, (20), 2011, p7259-7263Journal Article, 2011, DOI , URL , TARA - Full Text
  • Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ, Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aß in vivo., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369, (1633), 2014, p20130147Journal Article, 2014, DOI , TARA - Full Text
  • An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH, Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo., Molecular brain, 6, 2013, p47Journal Article, 2013, DOI , TARA - Full Text
  • Klyubin I, Cullen WK, Hu NW, Rowan MJ, Alzheimer's disease Aß assemblies mediating rapid disruption of synaptic plasticity and memory., Molecular brain, 5, 2012, p25Journal Article, 2012, DOI , TARA - Full Text
  • Qi YJ, Hu NW, Rowan MJ, Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus., Cerebral cortex (New York, N.Y. : 1991), 23, (4), 2013, p932 - 939Journal Article, 2013, DOI , TARA - Full Text
  • O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM, A monoclonal antibody against synthetic Aß dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aß., Journal of neurochemistry, 119, (1), 2011, p189-201Journal Article, 2011, DOI
  • Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, Rowan MJ, Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus., European Journal of Pharmacology, 677, (1-3), 2012, p63 - 70Journal Article, 2012, DOI
  • Adekar SP, Klyubin I, Macy S, Rowan MJ, Solomon A, Dessain SK, O'Nuallain B, Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains., The Journal of biological chemistry, 285, (2), 2010, p1066-74Journal Article, 2010, DOI
  • Ryan BK, Vollmayr B, Klyubin I, Gass P, Rowan MJ, Persistent inhibition of hippocampal long-term potentiation in vivo by learned helplessness stress., Hippocampus, 20, (6), 2010, p758-67Journal Article, 2010, DOI

Research Expertise

  • Title
    MEMOLOAD
    Summary
    Funding Agency
    European Union Framework 7
    Date From
    2007
    Date To
    2011
  • Title
    Mechanisms of the synaptic plasticity disrupting actions of Aß
    Summary
    Funding Agency
    Science Foundation Ireland Investigator Programme Grant
    Date From
    2006
    Date To
    2010
  • Title
    Neurocardiovascular influences on cognitive functioning
    Summary
    This Translational Programme Grant is a collaboration with Prof RoseAnne Kenny and Prof Brian Lawlor
    Funding Agency
    Health Research Board
    Date From
    2006
    Date To
    2011