Medicine

Contact Us School of Medicine
Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

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Dr. Igor Klyubin

Dr. Igor Klyubin

Senior Research Fellow, Pharmacology & Therapeutics

3531896 1566

Publications and Further Research Outputs

  • Yin Yang, Tomas Ondrejcak, Neng-Wei Hu, Sadia Islam, Eugene O'Rourke, Richard Reilly, Colm Cunningham, Michael Rowan, Igor Klyubin, Gamma-patterned sensory stimulation reverses synaptic plasticity deficits in rat models of early Alzheimer's disease, European Journal of Neuroscience, 58, (6), 2023, p3402 - 3411Journal Article, 2023, DOI
  • Zhang Y, Yang Y, Hu Z, Zhu M, Qin S, Yu P, Li B, Xu J, Ondrejcak T, Klyubin I and Rowan MJ, Hu NW, Long-term depression-inducing low frequency stimulation enhances p-Tau181 and p-Tau217 in an age-dependent manner in live rats, Journal of Alzheimer's Disease, 89, (1), 2022, p335--350Journal Article, 2022, DOI
  • Klyubin I, Ondrejcak T, Hu NW, Rowan MJ, Glucocorticoids, synaptic plasticity and Alzheimer's disease, Current Opinion in Endocrine and Metabolic Research, 25, 2022, p100365Journal Article, 2022, DOI
  • Ondrejcak T, Klyubin I, Hu NW, O'Malley TT, Corbett GT, Winters R, Perkinton MS, Billinton A, Prenderville JA, Walsh DM, Rowan MJ, Tau and amyloid ß protein in patient-derived aqueous brain extracts act concomitantly to disrupt LTP in vivo, The Journal of Neuroscience, 43, (32), 2023, p5870--5879Journal Article, 2023, DOI
  • Hu Z, Ondrejcak T, Yu P, Zhang Y, Yang Y, Klyubin I, Rowan MJ, Kennelly SP, Hu NW, Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease?, Neural Regeneration Research, 18, (6), 2023, p1213-1219Journal Article, 2023, DOI
  • Ondrejcak T, Klyubin I, Hu NW, Yang Y, Zhang Q, Rodriguez BJ and Rowan MJ, Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins, Philosophical Transactions of the Royal Society B, (379), 2024, p20230234Journal Article, 2024, DOI
  • Neng-Wei Hu, Tomas Ondrejcak, Igor Klyubin, Yin Yang, Dominic M. Walsh, Frederick J. Livesey, and Michael J. Rowan, Patient-derived tau and amyloid-ß facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response, Brain Communications, 2024, p10.1093/braincomms/fcae333Journal Article, 2024, DOI , TARA - Full Text
  • Klyubin, I, Wang, Q, Reed, MN, Irving, EA, Upton, N, Hofmeister, J, Cleary, JP, Anwyl, R, Rowan, MJ, Protection against Abeta-mediated rapid disruption of synaptic plasticity and memory by memantine., Neurobiology of Aging, 32, 2011, p614 - 633Journal Article, 2011, DOI
  • Hu NW, Klyubin I, Anwyl R, Rowan MJ, GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo, Proceedings of the National Academy of Sciences of the United States of America, 106, (48), 2009, p20504 - 20509Journal Article, 2009, TARA - Full Text
  • Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ, Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization., The Journal of Neuroscience, 28, (16), 2008, p4231-7Journal Article, 2008, DOI , URL , TARA - Full Text
  • Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J, Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites., Nature Communications, 2, (336), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
  • Barry, A.E., Klyubin, I., McDonald, J.M., Mably, A.J., Farrell, M.A., Scott, M., Walsh, D.M., Rowan, M.J., Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP In Vivo is prevented by immunotargeting cellular prion protein, Journal of Neuroscience, 31, (20), 2011, p7259-7263Journal Article, 2011, DOI , URL , TARA - Full Text
  • An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH, Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo., Molecular brain, 6, 2013, p47Journal Article, 2013, DOI , TARA - Full Text