Dr. Florian Sennlaub (Institut de la Vision, Paris) will be giving a research seminar entitled  

"How Genetic Risk Variants Drive Pathogenic Inflammation in Age-Related Macular Degeneration—A Path to Immune Restoration" this coming Friday at 11am in LB11 in the Lloyd building.

Date: Friday Jan 10th at 11am

Venue: LB11 lecture theatre, TCIN, Lloyd building

Dr. Florian Sennlaub earned his medical degree in Germany, followed by doctoral training and a Ph.D. in Paris, and completed his postdoctoral training in Montréal. In 2005, he joined INSERM and has led a research team at the Vision Institute in Paris since 2008. His laboratory investigates the role of innate immunity in retinal diseases, especially in age-related macular degeneration (AMD). His research has revealed how genetic AMD-risk variants influence innate immune cells, disrupt subretinal immune suppression, and hinder the resolution of inflammation. Collectively, his findings highlight the impact of these risk variants on inflammation in AMD, suggesting new therapeutic strategies to prevent pathogenic, non-resolving MP accumulation in AMD.

Selected Publications:

  1. Mathis, T., F…F. Sennlaub (2024). "DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration." J Clin Invest. doi : 10.1172/JCI174199
  2. Blot, G., …, F. Sennlaub and X. Guillonneau (2023). "Perilipin 2-positive mononuclear phagocytes accumulate in the diabetic retina and promote PPARgamma-dependent vasodegeneration." J Clin Invest. doi : 10.1172/JCI161348
  3. Roubeix, C., … F. Sennlaub (2024). "Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration." J Neuroinflammation. Doi : 10.1186/s12974-024-03011-z
  4. Augustin, S., … F. Sennlaub (2023). "Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker." J Neuroinflammation. Doi : 10.1186/s12974-023-02699-9
  5. Beguier, … Sennlaub F (2020). "The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination." Immunity 53(2): 429-441 e428.
  6. Calippe B, …, Sennlaub F (2017) Complement factor H inhibits CD47-mediated resolution of inflammation. Immunity. Feb 21;46(2):261-272
  7. Eandi CM, … Sennlaub F (2016). “Subretinal mononuclear phagocytes induce cone segment loss via IL-1beta”. Elife Jul 20;5. pii: e16490. doi: 10.7554/eLife.16490.
  8. Levy O, … Sennlaub F. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med. 2015; 7:211-226.
  9. Sennlaub, F., … C. Combadiere (2013). "CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice." EMBO Mol Med 5(11): 1775-1793.
  10. Combadiere, C., … Sennlaub, F. 2007. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest 117:2920-2928.