Dr. Roisin Mc Mackin

• McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B., Neurophysiological markers of network dysfunction in neurodegenerative diseases, Neuroimage Clin, 22, 2019, p101706-Journal Article, 2019, URL , TARA - Full Text
• McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Lalor EC, Muthuraman M, Hardiman O, Nasseroleslami B, Dysfunction of attention switching networks in amyotrophic lateral sclerosis. , Neuroimage Clin, 22, 2019, p101707-Journal Article, 2019, DOI , TARA - Full Text
• Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Lalor EC, Hardiman O, Nasseroleslami B., Patterned functional network disruption in amyotrophic lateral sclerosis. , Human Brain Mapping, 40, (16), 2019, p4827 - 4842Journal Article, 2019, URL
• McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis., Cerebral cortex (New York, N.Y. : 1991), 2020Journal Article, 2020, DOI
• Calvert GHM, McMackin R, Carson RG., Probing interhemispheric dorsal premotor-primary motor cortex interactions with threshold hunting transcranial magnetic stimulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 131, (11), 2020, p2551-2560Journal Article, 2020, DOI
• McMackin R, Dukic S, Costello E, Pinto-Grau M, Keenan O, Fasano A, Buxo T, Heverin M, Reilly RB, Pender N, Hardiman O, Nasseroleslami B, Sustained attention to response task-related beta oscillations relate to performance and provide a functional biomarker in ALS., Journal of neural engineering, 18, (2), 2021, p026006Journal Article, 2021, DOI
• McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. , Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis., Neurobiol Aging, 104, 2021, p57-70Journal Article, 2021
• Costello E, Rooney J, Pinto-Grau M, Burke T, Elamin M, Bede P, McMackin R, Dukic S, Vajda A, Heverin M, Hardiman O, Pender N. , Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study. , J Neurol Neurosurg Psychiatry. , 92, (5), 2021, p460-465Journal Article, 2021, TARA - Full Text
• Dukic S, McMackin R, Costello E, Metzger M, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, McLaughlin R, Pender N, Bede P, Muthuraman M, van den Berg L, Hardiman O, Nasseroleslami B., Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis., Brain : a journal of neurology, (awab3222), 2021Journal Article, 2021, DOI
• McMackin R, Bede P, Ingre C, Malaspina A, Hardiman O., Biomarkers in amyotrophic lateral sclerosis: current status and future prospects., Nat Rev Neurol., 2023Journal Article, 2023, URL
• Metzger M, Dukic S, McMackin R, Giglia E, Mitchell M, Bista S, Costello E, Peelo C, Tadjine Y, Sirenko V, Plaitano S, Coffey A, McManus L, Farnell Sharp A, Mehra P, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis., Hum Brain Mapp., 2023Journal Article, 2023, DOI
• Dukic S, Fasano A, Coffey A, Buxó T, McMackin R, Chipika R, Heverin M, Bede P, Muthuraman M, Lowery M, Carson RG, Hardiman O, Nasseroleslami B., Electroencephalographic ß-band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis., Eur J Neurol., 2024Journal Article, 2024, DOI , URL
• Roisin McMackin, Yasmine Tadjine, Antonio Fasano, Matthew Mitchell, Mark Heverin, Friedemann Awiszus, Bahman Nasseroleslami, Richard G Carson, Orla Hardiman, Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS, Clinical Neurophysiology Practice, 13, (9), 2024, p120 - 129Journal Article, 2024, DOI , URL , TARA - Full Text

Dr McMackin's research includes the use of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to investigate neural network function in health and neurodegenerative diseases. Her research aims are (i) to improve understanding of the cellular, neurochemical and and network physiology captured by electrophysiological measurements and (ii) to use electrophysiological measurements to progress understanding of neurodegenerative disease mechanisms, to identify diagnostic and prognostic biomarkers and to improve the outcome measures used to test potential therapies in neurological clinical trials. Dr McMackin has a particular interest in amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease, and Huntington's Disease. Dr McMackin is also actively involved in preclinical drug development wet lab studies.

Genetics, Medical and biomedical engineering, Medical, health and life sciences, Psychology and cognitive sciences, Neurosciences, Pharmacology and pharmaceutical sciences,

• Barbara Ryan Prize (TCD) 2015
• Trinity College Dublin Non-Foundation Scholarship 2014
• Eli Lilly Chemistry Prize 2013
• Neuroscience Ireland Early Career Investigator Award 2022
• Julian Boldy Prize (TCD) 2013
• Trinity College Dublin University Gold Medal 2016
• Omniscient Neurotechnology Infinitome Imaging Award 2021
• Brainbox Research Challenge Award 2020

• Neuroscience Ireland Present
• Irish Electrophysiology Research Clinic Present
• Royal Academy of Medicine in Ireland Present

• Trinity College Dublin Representative of the Neuroscience Ireland Committee 14/08/2023
• Coordinator of Civic Engagement activities for the Discipline of Physiology 01/2024