Dr. Hugh Kearney

• de Looze, C. and Beausang, A. and Cryan, J. and Loftus, T. and Buckley, P.G. and Farrell, M. and Looby, S. and Reilly, R. and Brett, F. and Kearney, H., Machine learning: a useful radiological adjunct in determination of a newly diagnosed glioma†s grade and IDH status, Journal of Neuro-Oncology, 2018, p491-499Journal Article, 2018, DOI , URL
• Benson KA, White M, Allen NM, Byrne S, Carton R, Comerford E, Costello D, Doherty C, Dunleavey B, El-Naggar H, Gangadharan N, Heavin S, Kearney H, Cavalleri GL, A comparison of genomic diagnostics in adults and children with epilepsy and comorbid intellectual disability., European journal of human genetics : EJHG, 2020Journal Article, 2020
• McCrea Z, Power K, Kiersey R, White M, Breen A, Murphy S, Healy L, Kearney H, Dunleavy B, O'Donoghue S, Lambert V, Delanty N, Doherty C, Fitzsimons M, Coproducing health and well-being in partnership with patients, families, and healthcare providers: A qualitative study exploring the role of an epilepsy patient portal., Epilepsy & behavior : E&B, 2020Journal Article, 2020
• Hugh Kearney, Jane Cryan, Alan Beausung, Seamus Looby, Francesca M. Brett, Reactive gliosis mimicking tumor recurrence " a case series documenting MRI abnormalities and neuropathological correlates, Clinical Neuropathology, 37, (05), 2018, p97--104Journal Article, 2018
• Francesca M. Brett, Hugh Kearney, Neuropathology correlates of cognitive assessments, Irish Journal of Medical Science (1971 -), 187, (3), 2018, p835--844Journal Article, 2018
• Siew Mei Yap, Mark S. Etzelmueller, Clodagh O'Keeffe, Maria Gaughan, Hugh Kearney, Niall Tubridy, Richard B. Reilly, Christopher McGuigan, Postural stability is a valid and meaningful disability metric in progressive MS with potential for use in neuroprotective therapy trials, Multiple Sclerosis and Related Disorders, 52, 2021, p102946Journal Article, 2021, DOI
• Schwarz, N., Seiffert, S., Pendziwiat, M., Rademacher, A., Brünger, T., Hedrich, U.B.S., Augustijn, P.B., Baier, H., Bayat, A., Bisulli, F., Buono, R.J., Bruria, B.Z., Doyle, M.G., Guerrini, R., Heimer, G., Iacomino, M., Kearney, H., Klein, K.M., Kousiappa, I., Kunz, W.S., Lerche, H., Licchetta, L., Lohmann, E., Minardi, R., McDonald, M., Montgomery, S., Mulahasanovic, L., Oegema, R., Ortal, B., Papacostas, S.S., Ragona, F., Granata, T., Reif, P.S., Rosenow, F., Rothschild, A., Scudieri, P., Striano, P., Tinuper, P., Tanteles, G.A., Vetro, A., Zahnert, F., Zara, F., Lal, D., May, P., Muhle, H., Helbig, I., Weber, Y., Heterozygous variants in KCNC2 cause a broad spectrum of epilepsy phenotypes associated with characteristic functional alterations, medRxiv, 2021Journal Article, 2021, DOI
• , The Human Phenotype Ontology in 2021., Nucleic acids research, 2021Journal Article, 2021, DOI
• , Location-specific reflex epilepsy: a novel reflex epilepsy phenotype., Epilepsy & behavior reports, 2020Journal Article, 2020, DOI
• Hugh Kearney, Tucker Price, Jane Cryan, Alan Beausang, Seamus Looby, Francesca M. Brett, Michael Farrell, Acute multiple sclerosis lesion pathology does not predict subsequent clinical course"a biopsy study, Irish Journal of Medical Science (1971 -), 188, (4), 2019, p1427--1434Journal Article, 2019, DOI
• , Spatial distribution of multiple sclerosis lesions in the cervical spinal cord., Brain : a journal of neurology, 2019Journal Article, 2019, DOI
• , Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks., NeuroImage, 2018Journal Article, 2018, DOI
• Gros, C., de Leener, B., Badji, A., Maranzano, J., Eden, D., Dupont, S.M., Talbott, J., Zhuoquiong, R., Liu, Y., Granberg, T., Ouellette, R., Tachibana, Y., Hori, M., Kamiya, K., Chougar, L., Stawiarz, L., Hillert, J., Bannier, E., Kerbrat, A., Edan, G., Labauge, P., Callot, V., Pelletier, J., Audoin, B., Rasoanandrianina, H., Brisset, J.-C., Valsasina, P., Rocca, M.A., Filippi, M., Bakshi, R., Tauhid, S., Prados, F., Yiannakas, M., Kearney, H., Ciccarelli, O., Smith, S., Treaba, C.A., Mainero, C., Lefeuvre, J., Reich, D.S., Nair, G., Auclair, V., McLaren, D.G., Martin, A.R., Fehlings, M.G., Vahdat, S., Khatibi, A., Doyon, J., Shepherd, T., Charlson, E., Narayanan, S., Cohen-Adad, J., Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks, arXiv, 2018Journal Article, 2018
• Kearney, H., Cahalane, A.M., Killeen, R.P., McGuigan, C., Correction to: MRI and multiple sclerosis"the evolving role of MRI in the diagnosis and management of MS: a clinician"s perspective (Irish Journal of Medical Science (1971), (2018), 187, 2, (493-498), 10.1007/s11845-017-1691-z), Irish Journal of Medical Science, 187, (2), 2018, p499Journal Article, 2018, DOI
• , Fully automated grey and white matter spinal cord segmentation., Scientific reports, 2016Journal Article, 2016, DOI
• Kearney, H., Krakar, A., Drazyk, A., Maloney, E., Callanan, I., Tubridy, N., An audit of the effectiveness of large group neurology tutorials for irish undergraduate medical students, Irish Medical Journal, 109, (7), 2016, p438Journal Article, 2016
• , Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis., NeuroImage. Clinical, 2015Journal Article, 2015, DOI
• , Getting a handle on complicated migraine., BMJ case reports, 2015Journal Article, 2015, DOI
• , The patient knows best: significant change in the physical component of the Multiple Sclerosis Impact Scale (MSIS-29 physical)., Journal of neurology, neurosurgery, and psychiatry, 2007Journal Article, 2007, DOI
• Kearney, H., Delanty, N., Felbamate in an adult population with severe refractory epilepsy, Irish Medical Journal, 102, (10), 2009Journal Article, 2009
• Siew Mei Yap and Laura Davenport and Clodagh Cogley and Fiona Craddock and Alex Kennedy and Maria Gaughan and Hugh Kearney and Niall Tubridy and Cé, Word finding, prosody and social cognition in multiple sclerosis, Journal of Neuropsychology, 2022Journal Article, 2022, DOI
• , Vaccine hesitancy among people with multiple sclerosis., Multiple sclerosis and related disorders, 2021Journal Article, 2021, DOI
• David Lewis"Smith, Peter D. Galer, Ganna Balagura, Hugh Kearney, Shiva Ganesan, Mahgenn Cosico, Margaret O'Brien, Priya Vaidiswaran, Roland Krause, Colin A. Ellis, Rhys H. Thomas, Peter N. Robinson, Ingo Helbig, Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable, Epilepsia, 62, (6), 2021, p1293--1305Journal Article, 2021, DOI
• Yiannakas MC, Kearney H, Samson RS, Chard DT, Ciccarelli O, Miller DH, Wheeler-Kingshott CA., Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: a pilot study with application to magnetisation transfer measurements., NeuroImage, 63, (3), 2012, p1054-1059Journal Article, 2012, DOI
• Kearney H, O'Dowd S, Murray B, Kavanagh E, O'Connell M, Lynch T., Re-emergence of artistic traits in a patient with frontotemporal dementia., Clinical neurology and neurosurgery, 114, (4), 2012, p417-420Journal Article, 2012, DOI
• Kearney H, Murray B, Kavanagh E, O'Rourke K, Kelly P, Lynch T., Autoimmune encephalopathy presenting as a 'posterior circulation stroke'., Journal of neurology, 258, (2), 2011, p330-332Journal Article, 2011, DOI
• Kearney H, Mallon P, Kavanagh E, Lawler L, Kelly P, O'Rourke K., Amnestic syndrome due to meningovascular neurosyphilis., Journal of neurology, 257, (4), 2010, p669-671Journal Article, 2010, DOI
• Valsasina P, Gobbi C, Zecca C, Rovira A, Sastre-Garriga J, Kearney H, Yiannakas M, Matthews L, Palace J, Gallo A, Bisecco A, Gass A, Eisele P, Filippi M, Rocca MA, MAGNIMS Study Group;., Characterizing 1-year development of cervical cord atrophy across different MS phenotypes: A voxel-wise, multicentre analysis., Multiple sclerosis (Houndmills, Basingstoke, England), 28, (6), 2022, p885-899Journal Article, 2022, DOI
• Rocca MA, Valsasina P, Meani A, Gobbi C, Zecca C, Rovira A, Sastre-Garriga J, Kearney H, Ciccarelli O, Matthews L, Palace J, Gallo A, Bisecco A, Lukas C, Bellenberg B, Barkhof F, Vrenken H, Preziosa P, Filippi M, MAGNIMS Study Group., Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis., Neurology, 96, (11), 2021, pe1561-e1573Journal Article, 2021, DOI
• Togher Z, Fullam S, Callanan I, Kearney H, Tubridy N., An evaluation of optimal tutorial methodologies for neurology teaching at undergraduate level : Optimal tutorial methods for neurology., Ir J Med Sci, 190, (3), 2021, p965-969Journal Article, 2021, DOI
• Elseed M, Baheerathan A, Kearney H, Abkur T., Reversible splenial lesion syndrome., British journal of hospital medicine (London, England : 2005), 80, (12), 2019, p734-735Journal Article, 2019, DOI
• Rocca MA, Valsasina P, Meani A, Gobbi C, Zecca C, Rovira À, Montalban X, Kearney H, Ciccarelli O, Matthews L, Palace J, Gallo A, Bisecco A, Gass A, Eisele P, Lukas C, Bellenberg B, Barkhof F, Vrenken H, Preziosa P, Comi G, Filippi M, MAGNIMS Study Group., Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS., Neurology, 93, (20), 2019, pe1852-e1866Journal Article, 2019, DOI
• Kearney H, Byrne S, Cavalleri GL, Delanty N., Tackling Epilepsy With High-definition Precision Medicine: A Review., JAMA neurology, 76, (9), 2019, p1109-1116Journal Article, 2019, DOI
• Kearney H., Reader response: Subcutaneous ofatumumab in patients with relapsing-remitting multiple sclerosis: The MIRROR study., Neurology, 92, (11), 2019, p542-543Journal Article, 2019, DOI
• Lorigan J, Kearney H, Grimes B, Heffernan J, Beausang A, Cryan J, Farrell MA, Brett FM., Evaluation of the specificity of the central diagnostic criterion for chronic traumatic encephalopathy., Ir J Med Sci, 188, (3), 2019, p993-998Journal Article, 2019, DOI
• Kearney H., Clinical monitoring of multiple sclerosis should routinely include spinal cord imaging - No., Multiple sclerosis (Houndmills, Basingstoke, England), 24, (12), 2018, p1537-1539Journal Article, 2018, DOI
• Frazer B, Kearney H, Cryan J, Beausang A, Brett F, Farrell MA, Buckley PG., Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas., Clinical neuropathology, 37, (4), 2018, p182-185Journal Article, 2018, DOI
• Al Hussona M, Kearney H, Fisher A, Lynch J, Looby S, Delanty N., New onset seizures as a sole clinical presentation of multiple sclerosis., Multiple sclerosis (Houndmills, Basingstoke, England), 25, (2), 2019, p295-299Journal Article, 2019, DOI
• Kearney H, Beausang A., A 3-year old female with an atypical pineal tumor., Clinical neuropathology, 37, (3), 2018, p156-158Journal Article, 2018, DOI
• Kearney H, Cryan JB, Looby S, Brett FM, Farrell MA, Buckley PG., The DNA copy number landscape of a collision tumor., Clinical neuropathology, 37, (2), 2018, p68-73Journal Article, 2018, DOI
• Kearney H, Cahalane AM, Killeen RP, McGuigan C., Correction to: MRI and multiple sclerosis-the evolving role of MRI in the diagnosis and management of MS: a clinician's perspective., Ir J Med Sci, 187, (2), 2018, p499Journal Article, 2018, DOI
• O'Regan CJ, Kearney H, Beausang A, Farrell MA, Brett FM, Cryan JB, Loftus TE, Buckley PG., Temporal stability of MGMT promoter methylation in glioblastoma patients undergoing STUPP protocol., Journal of neuro-oncology, 137, (2), 2018, p233-240Journal Article, 2018, DOI
• Abkur TM, Kearney H, Hennessy MJ., Refractory epilepsy following natalizumab associated PML., Multiple sclerosis and related disorders, 20, 2018, p1-2Journal Article, 2018, DOI
• Cahalane AM, Kearney H, Purcell YM, McGuigan C, Killeen RP., MRI and multiple sclerosis--the evolving role of MRI in the diagnosis and management of MS: the radiologist's perspective., Ir J Med Sci, 187, (3), 2018, p781-787Journal Article, 2018, DOI
• Kearney H, Cahalane AM, Killeen RP, McGuigan C., MRI and multiple sclerosis-the evolving role of MRI in the diagnosis and management of MS: a clinician's perspective., Ir J Med Sci, 187, (2), 2018, p493-498Journal Article, 2018, DOI
• Brett FM, Looby S, Chalissery A, Chen D, Heaney C, Heffernan J, Cunningham F, Howley R, Loftus T, Kearney H, Farrell MA., Brain biopsies requiring Creutzfeldt-Jakob disease precautions in the Republic of Ireland 2005-2016., Ir J Med Sci, 187, (2), 2018, p515-520Journal Article, 2018, DOI
• Cawley N, Tur C, Prados F, Plantone D, Kearney H, Abdel-Aziz K, Ourselin S, Wheeler-Kingshott CAG, Miller DH, Thompson AJ, Ciccarelli O., Spinal cord atrophy as a primary outcome measure in phase II trials of progressive multiple sclerosis., Multiple sclerosis (Houndmills, Basingstoke, England), 24, (7), 2018, p932-941Journal Article, 2018, DOI
• Abkur TM, Kearney H, Hennessy MJ., CLIPPERS and the need for long-term immunosuppression., Scottish medical journal, 62, (1), 2017, p28-33Journal Article, 2017, DOI
• Kearney H, Krakar A, Drazyk A, Maloney E, Callinan I, Tubridy N., An Audit of the Effectiveness of Large Group Neurology Tutorials for Irish Undergraduate Medical Students., Irish medical journal, 109, (7), 2016, p438Journal Article, 2016, DOI
• Abkur TM, Foran E, Kearney H, Harkin G, Byrnes V, Lynch J., Neuromyelitis optica presenting as intractable vomiting and hyperCKaemia., Journal of neurology, 263, (1), 2016, p171-173Journal Article, 2016, DOI
• Kearney H, Miszkiel KA, Yiannakas MC, Altmann DR, Ciccarelli O, Miller DH., Grey matter involvement by focal cervical spinal cord lesions is associated with progressive multiple sclerosis., Multiple sclerosis (Houndmills, Basingstoke, England), 22, (7), 2016, p910-920Journal Article, 2016, DOI
• Kearney H, Miller DH, Ciccarelli O., Spinal cord MRI in multiple sclerosis--diagnostic, prognostic and clinical value., Nature reviews. Neurology, 11, (6), 2015, p327-338Journal Article, 2015, DOI
• Quigley S, Yiannakas MC, Bede P, Meaney J, Kearney H., Neuropathologically informed imaging of cortical grey matter lesions in MS - A pilot study., Mult Scler Relat Disord., 2023Journal Article, 2023
• Quigley, S., Asad, M., Doherty, C., Byrne, D., Cronin, S., Kearney, H., Concurrent diagnoses of Tuberous sclerosis and multiple sclerosis, Multiple Sclerosis and Related Disorders, 71, 2023Journal Article, 2023, DOI
• Matthew M. O'Riordan, Mark T. Cahill, Matthew Campbell, Hugh Kearney, Evaluation of Inflammation in the Peripheral Multiple Sclerosis Retina Using Ultra-Widefield Optical Coherence Tomography: A Pilot Study, Ophthalmic Surgery, Lasers and Imaging Retina, 54, (10), 2023, p586--588Journal Article, 2023, DOI
• Bradley M, Field RH, O'Rourke M, Stoke J, Murphy SM, Kearney H., Novel phenotype of SIN3A-related disorder diagnosed in adulthood with multi-system involvement., European journal of human genetics : EJHG, 32, (3), 2024, p257-259Journal Article, 2024, DOI
• Eltahir M, Abkur T, Kearney H, Rice CM., Lingual epilepsy due to cortical demyelination involving the frontal operculum., Practical neurology, 24, (3), 2024, p248-249Journal Article, 2024, DOI
• Dungan L, Dunne J, Savio M, Kalaszi M, McElheron M, Lynagh Y, O'Driscoll K, Roche C, Qureshi A, Crowley B, Conlon N, Kearney H., Disease-Modifying Treatments for Multiple Sclerosis Affect Measures of Cellular Immune Responses to EBNA-1 Peptides., Neurology(R) neuroimmunology & neuroinflammation, 11, (3), 2024, pe200217Journal Article, 2024, DOI
• Carton RJ, Doyle MG, Kearney H, Steward CA, Lench NJ, Rogers A, Heinzen EL, McDonald S, Fay J, Lacey A, Beausang A, Cryan J, Brett F, El-Naggar H, Widdess-Walsh P, Costello D, Kilbride R, Doherty CP, Sweeney KJ, O'Brien DF, Henshall DC, Delanty N, Cavalleri GL, Benson KA., Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis., Epilepsia, 65, (5), 2024, p1451-1461Journal Article, 2024, DOI
• Moloney PB, Kearney H, Benson KA, Costello DJ, Cavalleri GL, Gorman KM, Lynch BJ, Delanty N., Everolimus precision therapy for the GATOR1-related epilepsies: A case series., European journal of neurology, 30, (10), 2023, p3341-3346Journal Article, 2023, DOI
• B. Dwyer, C. Flynn, S. Murphy, I. Callanan, H. Kearney, A Quality Improvement Project on Seizure Referral Triage: Preliminary Outcomes and Implications for Further Research, Irish Medical Journal, 115, (5), 2022, p600 - 603Journal Article, 2022, URL
• Kohler S., Gargano M., Matentzoglu N., Carmody L.C., Lewis-Smith D., Vasilevsky N.A., Danis D., Balagura G., Baynam G., Brower A.M., Callahan T.J., Chute C.G., Est J.L., Galer P.D., Ganesan S., Griese M., Haimel M., Pazmandi J., Hanauer M., Harris N.L., Hartnett M.J., Hastreiter M., Hauck F., He Y., Jeske T., Kearney H., Kindle G., Klein C., Knoflach K., Krause R., Lagorce D., McMurry J.A., Miller J.A., Munoz-Torres M.C., Peters R.L., Rapp C.K., Rath A.M., Rind S.A., Rosenberg A.Z., Segal M.M., Seidel M.G., Smedley D., Talmy T., Thomas Y., Wiafe S.A., Xian J., Yuksel Z., Helbig I., Mungall C.J., Haendel M.A., Robinson P.N., The human phenotype ontology in 2021, Nucleic Acids Research, 49, (D1), 2021, pD1207 - D1217, pD1207-D1217Journal Article, 2021, DOI
• Meldrum D., Kearney H., Hutchinson S., McCarthy S., Quinn G., Wearable sensor and smartphone assisted vestibular physical therapy for multiple sclerosis: usability and outcomes, Frontiers in Rehabilitation Sciences, 5, 2024Journal Article, 2024, DOI
• Almudena Otálora-Alcaraz, Thomas Reilly, Martí Oró-Nolla, Melody Cui Sun, Lisa Costelloe, Hugh Kearney, Pabitra H. Patra, Eric J. Downer, The NLRP3 inflammasome: a central player in multiple sclerosis, Biochemical Pharmacology, ((in press)), 2024Journal Article, 2024, DOI

I am a neurologist working in St James's Hospital and run the multiple sclerosis (MS) service. Arising from my clinical work my research interests are based in MS and link to clinical observations. There are two research priorities that my work focuses on: delay to diagnosis and misdiagnosis. To address these problems I am developing new diagnostic biomarkers through clinically based research.

Neurosciences,

• Harold Miller Prize at INA 2018
• Harold Miller Prize at INA 2015
• Neuropathology fellowship award 2018

• American Academy of Neurology
• Irish Institute of Clinical Neuroscience
• European Academy of Neurology