Dr. Dania Movia

Adjunct Assistant Professor, Radiation Therapy

dmovia@tcd.ie ie.linkedin.com/pub/dania-movia/3a/51b/725/

Biography

Dr. Dania Movia is a dynamic Assistant Professor in Biomedical & Health Services at the Department of Biology, Maynooth University. She also serves as Principal Investigator at the Kathleen Lonsdale Institute for Human Health Research, where her groundbreaking work continues to advance the respiratory research field. In addition, Dr Movia holds the position of Adjunct Assistant Professor at the Discipline of Radiation Therapy, Trinity College Dublin, Ireland, further solidifying her presence in the academic and research communities. Dr Movia's academic journey began with a degree in Chemistry and Pharmaceutical Technologies, which she earned from the University of Trieste, Italy, in 2007. She went on to obtain her PhD from Trinity College Dublin in 2012. Trinity College later conferred upon her a Special Purpose Certificate in Academic Practice in 2018, and a Master of Arts (jure officii) in 2023 as a recognition of her ongoing contributions to the College. A dedicated member of numerous esteemed professional organizations, Dr Movia plays a key role in shaping the future of cancer research and alternatives to animal testing. Her affiliations include the Irish Lung Cancer Alliance (ILCA), Cancer Trials Ireland, the European Association for Cancer Research (EACR), and the European Society for Alternatives to Animal Testing (EUSAAT), the European 3Rs Society that actively promotes the implementation of the 3Rs Principle (Reduce, Refine and Replace) in animal research. She also lends her expertise to the scientific advisory panels of Animal-Free Research UK and FRAME-UK and contributes to the COST Action CA21139 initiative - "3Rs Concepts to Improve the Quality of Biomedical Science (IMPROVE)." With over 50 peer-reviewed publications to her name, Dr. Movia is a prolific contributor to scientific literature. In her editorial roles, she has served as Guest Editor for Animals (MDPI) and Frontiers in Bioengineering and Biotechnology, and she co-edited the book Cancer Cell Culture in the renowned Methods in Molecular Biology series published by Springer Nature. This work, featuring contributions from 38 international experts, stands as a testament to her collaborative spirit and leadership in the field. She currently serves as an Associate Editor for Frontiers in Pharmacology, continuing to influence and guide cutting-edge research. Dr Movia's commitment to scientific excellence, her diverse roles, and her dedication to fostering innovation through sustainable animal-free research make her a leader in the biomedical field.

Dr Dania Movia is an Assistant Professor of the Discipline of Radiation Therapy. She is also Principal Investigator of the Laboratory for Biological Characterisation of Advanced Materials (LBCAM) at the Trinity Translational Medicine Institute (TTMI), associated with the Trinity St James's Cancer Institute.

She received her PhD at Trinity College Dublin in 2012, and subsequently she was awarded a Special Purpose Certificate in Academic Practice by the same university in 2018.

Dr Movia champions the reduction and replacement of animal testing via research and training of young scientists. Her current research work focuses on developing new, non-animal methodologies (NAMs) that can replace animal studies in cancer and lung toxicity research. These technologies are based on human cells growing as complex, 3D in vitro tissues, outside the human body.

Dr Movia has received support and funding from several organisations including the Irish Research Council (IRC), Science Foundation Ireland (SFI), Animal-Free Research UK, the Johns Hopkins Center for Alternatives to Animal Testing Award (CAAT), and the European Commission. She has authored more than 40 peer-reviewed publications, edited 1 e-book and she has acted as Guest Editor in "Animals" (MDPI) and "Front. Bioeng. Biotechnol." (Frontiers) journals. She is currently editing a book for the book series Methods in Molecular Biology, published by Springer Nature.

Dr Movia is part of the Scientific Advisory Panel of Animal-Free Research UK and FRAME. She is also a member of a number of professional bodies and organisations, which include the Irish Lung Cancer Alliance (ILCA) and Cancer Trials Ireland.

Dr Movia lectures in the Trinity BSc in Radiation Therapy and in the MSc in Molecular Medicine.

An updated list of her publications can be found at: https://scholar.google.com/citations?user=T60uEacAAAAJ&hl=en&oi=ao

Dr Dania Movia Assistant Professor in Biomedical & Health Services at the Department of Biology at Maynooth University. Adjunct Assistant Professor at Radiation Therapy of Trinity College Dublin.

Dr Dania Movia is an Assistant Professor in Biomedical & Health Services at the Department of Biology at Maynooth University. She is also an Adjunct Assistant Professor at the Discipline of Radiation Therapy of Trinity College Dublin. She graduated in Chemistry and Pharmaceutical Technologies in 2007 from the University of Trieste (Italy). She then obtained her PhD at Trinity College Dublin in 2012, and she was awarded a Special Purpose Certificate in Academic Practice and a Master in Arts (jure officii) by the same university in 2018 and 2023, respectively.

Dr Movia champions the reduction/replacement of animal testing via research and training of young scientists. Her current research work focuses on developing new, non-animal methodologies (NAMs) that can replace animal studies in lung cancer and lung toxicity research. Recently, she established the first wet-lab on animal-free lung translational research in the Republic of Ireland, the Humane Biomedical Research Lab, housed at the Biomedical Sciences building in the Maynooth University North Campus. Her research group collaborates closely with the LBCAM, through the exchange of expertise and research interests.

Dr Movia has received funding in excess of €2M from several national, European and international agencies, and has authored more than 45 peer-reviewed publications. She is part of several professional bodies and organisations, which include the Irish Lung Cancer Alliance and Cancer Trials Ireland, and an active member of the scientific advisory panels of Animal-Free Research UK and FRAME-UK.

Publications and Further Research Outputs

Peer-Reviewed Publications
Non-Peer-Reviewed Publications

Bianca M Rotoli, Rita Gatti, Dania Movia, Massimiliano G Bianchi, Luisana Di Cristo, Ivana Fenoglio, Fabio Sonvico, Enrico Bergamaschi, Adriele Prina-Mello, Ovidio Bussolati, Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay, Nanotoxicology, 9, (2), 2015, p230-241Journal Article, 2015, DOI
Del Canto, E., Flavin, K., Movia, D., Navio, C., Bittencourt, C., Giordani, S., Critical investigation of defect site functionalization on single-walled carbon nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74Journal Article, 2011, DOI
Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E, Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences, 150, (1), 2016, p40-53Journal Article, 2016, DOI , TARA - Full Text
Spadavecchia J, Movia D, Moore C, Maguire CM, Moustaoui H, Casale S, Volkov Y, Prina-Mello A, Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies., International journal of nanomedicine, 11, 2016, p791-822Journal Article, 2016, DOI , TARA - Full Text
Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, Janer G, Fuentes N, Vázquez-Campos S, Borges T, Silva MJ, Prina-Mello A, Movia D, Nesslany F, Ribeiro AR, Leite PE, Groenewold M, Cassee FR, Sips AJ, Dijkzeul A, van Teunenbroek T, Wijnhoven SW, Towards a nanospecific approach for risk assessment., Regulatory toxicology and pharmacology : RTP, 80, 2016, p46-59Journal Article, 2016, DOI , TARA - Full Text
Moustaoui H, Movia D, Dupont N, Bouchemal N, Casale S, Djaker N, Savarin P, Prina-Mello A, De La Chapelle M.L, Spadavecchia J, Tunable Design of Gold(III)-Doxorubicin Complex-PEGylated Nanocarrier. the Golden Doxorubicin for Oncological Applications, ACS Applied Materials and Interfaces, 8, (31), 2016, p19946 - 19957Journal Article, 2016, DOI , URL
Moore C., Movia D., Smith R., Hanlon D., Lebre F., Lavelle E., Byrne H., Coleman J., Volkov Y., McIntyre J., Industrial grade 2D molybdenum disulphide (MoS2): an in vitro exploration of the impact on cellular uptake, cytotoxicity, and inflammation, 2D Materials, 4, (2), 2017Journal Article, 2017, DOI , URL
Movia D., Di Cristo L., Alnemari R., McCarthy J. E., Moustaoui H., Lamy de la Chapelle M., Spadavecchia J., Volkov Y., Prina-Mello A., The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles, Journal of Interdisciplinary Nanomedicine, 2, (2), 2017, p110 - 130Journal Article, 2017, DOI
Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids in, editor(s)Ferreira de Castro Gomes Andreia, Sárria Pereira Passos Marisa. , Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications, InTech, 2018, [Movia D., Prina-Mello A.]Book Chapter, 2018, TARA - Full Text
Adriele Prina-Mello, Namrata Jain, Baiyun Liu, Jason I. Kilpatrick, Melissa A. Tutty, Alan P. Bell, Suzanne P Jarvis, Yuri Volkova, Dania Movia, Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D, Tissue and Cell, 50, 2018, p15 - 30Journal Article, 2018, DOI
Di Cristo, L. and Maguire, C.M. and Mc Quillan, K. and Aleardi, M. and Volkov, Y. and Movia, D. and Prina-Mello, A., Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials, International Journal of Environmental Research and Public Health, 15, (4), 2018Journal Article, 2018, DOI , URL , TARA - Full Text
Cristina Multari, Marta Miola, Sara Ferraris, Dania Movia, Kristina Žužek Rožman, Nina Kostevšek, Antonia Follenzi, Enrica Verné, Adriele Prina-Mello, Synthesis and characterization of silica-coated superparamagnetic iron oxide nanoparticles and interaction with pancreatic cancer cells, International Journal of Applied Ceramic Technology, 2018Journal Article, 2018
Luisana Di Cristo, Sarah Mc Carthy, Keith Paton, Dania Movia, Adriele Prina-Mello, Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages, 2D Materials, 2018Journal Article, 2018
Adriele Prina-Mello and Dania Movia and Despina Bazou and Yuri Volkov and Adriele Prina-Mello, Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs, Scientific Reports, 2018, p12920-Journal Article, 2018, DOI , URL , TARA - Full Text
Moustaoui H, Saber J, Djeddi I, Liu Q, Movia D, Prina-Mello A, Spadavecchia J, Lamy de la Chapelle M, Djaker N., A protein corona study by scattering correlation spectroscopy: a comparative study between spherical and urchin-shaped gold nanoparticles., Nanoscale, 11, (8), 2019, p3665-3673Journal Article, 2019, DOI
Dania Movia, Despina Bazou, Adriele Prina-Mello, ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance, BMC Cancer, 19, (1), 2019Journal Article, 2019, DOI
Dania Movia, Maroua Benhaddada, Jolanda Spadavecchia, Adriele Prina-Mello, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies , Precision Nanomedicine, 3, (2), 2020, p495 - 524Review Article, 2020
Movia D, Prina-Mello A., Preclinical Development of Orally Inhaled Drugs (OIDs)-Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?, Animals : an open access journal from MDPI, 10, (8), 2020Review Article, 2020, DOI , TARA - Full Text
Movia D, Bruni-Favier S, Prina-Mello A., In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective., Frontiers in bioengineering and biotechnology, 8, 2020, p549Journal Article, 2020, DOI , TARA - Full Text
Haddada MB, Movia D, Prina-Mello A, Spadavecchia J., Docetaxel gold complex nanoflowers: A chemo-biological evaluation for their use as nanotherapeutics., Colloids and surfaces. B, Biointerfaces, 194, 2020, p111172Journal Article, 2020, DOI
Prina-Mello, A. and Bonacina, L. and Staedler, D. and Movia, D., Editorial: Use of 3D Models in Drug Development and Precision Medicine - Advances and Outlook, 1826, 2021, -Miscellaneous, 2021, DOI
Galligioni, V. and Movia, D. and Ruiz-Perez, D. and Sanchez-Morgado, J.M. and Prina-Mello, A., The Case for Modernizing Biomedical Research in Ireland through the Creation of An Irish 3Rs Centre, Animals, 12, (9), 2022Journal Article, 2022, DOI
Singh, B. and Abdelgawad, M.E. and Ali, Z. and Bailey, J. and Budyn, E. and Civita, P. and Clift, M.J.D. and Connelly, J.T. and Constant, S. and Hittinger, M. and Kandarova, H. and Kearns, V.R. and Kiuru, T. and Kostrzewski, T. and Kress, S. and Durban, V.M. and Lehr, C.-M. and McMillan, H. and Metz, J.K. and Monteban, V. and Movia, D. and Neto, C. and Owen, C. and Paasonen, L. and Palmer, K.A. and Pilkington, G.J. and Pilkington, K. and Prina-Mello, A. and Roper, C. and Sheard, J. and Smith, S. and Turner, J.E. and Roy, I. and Tutty, M.A. and Velliou, E. and Wilkinson, J.M., Towards more predictive, physiological and animal-free in vitro models: Advances in cell and tissue culture 2020 conference proceedings, ATLA Alternatives to Laboratory Animals, 49, (3), 2021, p93-110Journal Article, 2021, DOI , URL
Tutty, M.A. and Movia, D. and Prina-Mello, A., Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials, Drug Delivery and Translational Research, 2022Review Article, 2022, DOI
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, St"pnik M, Soba"ska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H., The Rise of Three Rs Centres and Platforms in Europe., Alternatives to laboratory animals : ATLA, 50, (2), 2022, p90-120Journal Article, 2022, DOI
Special Issue "Use of 3D Models in Drug Development and Precision Medicine: Advances and Outlook", Frontiers in Bioengineering and Biotechnology, 2020-2021Editorial Board, 2020
Special Issue "Replacing Animal Testing in Research"A Scientific and Regulatory Perspective of Current Efforts Towards the 1R", Animals (MDPI), 2021-2022Editorial Board, 2021
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Spielmann H, The Current Status and Work of Three Rs Centres and Platforms in Europe., Alternatives to laboratory animals : ATLA, 2022Journal Article, 2022, DOI
Soliman, M.G. and Trinh, D.N. and Ravagli, C. and Meleady, P. and Henry, M. and Movia, D. and Doumett, S. and Cappiello, L. and Prina-Mello, A. and Baldi, G. and Monopoli, M.P., Development of a fast and simple method for the isolation of superparamagnetic iron oxide nanoparticles protein corona from protein-rich matrices, Journal of Colloid and Interface Science, 659, 2024, p503-519Journal Article, 2024, DOI , URL
Mullen, S. and Movia, D., The role of extracellular vesicles in non-small-cell lung cancer, the unknowns, and how new approach methodologies can support new knowledge generation in the field, European Journal of Pharmaceutical Sciences, 188, (106516), 2023Journal Article, 2023, DOI , URL
Movia, D. and Prina-Mello, A., A Method for Culturing 3D Tumoroids of Lung Adenocarcinoma Cells at the Airâ"Liquid Interface, Methods in Molecular Biology, 2645, 2023, p173-178Journal Article, 2023, DOI , URL
Ripoll-Viladomiu, I. and Prina-Mello, A. and Movia, D. and Marignol, L., Extracellular vesicles and the â six Rsâ in radiotherapy, Cancer Treatment Reviews, 129, (102799), 2024Journal Article, 2024, DOI , URL
Preface in, editor(s)Raquel de Pedro Ricoy, Isabelle Perez and Christine Wilson , Interpreting and Translating in Public Service Settings Policy, Practice, Pedagogy, Manchester, St. Jerome, 2009, ppvii - viii, [Lorraine Leeson ]Book Chapter, 2009
Movia D., Del Canto E. and Giordani S., Spectroscopy of Single-Walled Carbon Nanotubes in Aqueous Surfactant Dispersion, physica status solidi (b), 246, (11-12), 2009, p2704 - 2707Journal Article, 2009, DOI , TARA - Full Text
Movia, D., Prina-Mello, A. , Volkov, Y. , Giordani, S, Determination of spiropyran cytotoxicity by high content screening and analysis for safe application in bionanosensing, Chemical Research in Toxicology , 23, (9), 2010, p1459 - 1466Journal Article, 2010, DOI , URL , TARA - Full Text
Movia D., Del Canto E., Giordani S., Purified and Oxidized Single Walled Carbon Nanotubes as Robust Near IR Fluorescent Probes for Molecular Imaging, Journal of Physical Chemistry C, 114, (43), 2010, p18407-18413Journal Article, 2010, DOI
Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, p502386Journal Article, 2011, DOI , TARA - Full Text
Del Canto E., Flavin K., Movia D., Navio C., Bittencourt C., Giordani S., A Critical Investigation of Defect Site Functionalization on Single Walled Carbon Nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74Journal Article, 2011, DOI
Toxicity of carbon nanotubes in, Handbook of Green Chemistry - Green Processes (- Green Nanoscience), Germany, Wiley - VCH, 2013, pp175 - 216 , [Movia D. and Giordani S.]Book Chapter, 2013
Del Canto E., Flavin K., Movia D., Giordani S., Oxidized Single-Walled Carbon Nanotubes: removal of carbonaceous functionalized material by washing with solvents or base, MRS Proceedings, 1362, 2011, pmrss11-1362-qq09-44Journal Article, 2011, DOI
Movia D, Prina-Mello A, Bazou D, Volkov Y, Giordani S, Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models., ACS Nano, 5, (11), 2011, p9278-9290Journal Article, 2011, DOI
Del Canto E., Natali M., Movia D. and Giordani S., Photo-controlled Uptake and Release of Zinc Metal Ions by Spiropyran receptors anchored to Single-Walled Carbon Nanotubes, Phys. Chem. Chem. Phys. , 14, (17), 2012, p6034 - 6043Journal Article, 2012, DOI , TARA - Full Text
Multilayered nanoparticles for personalized medicine: translation into clinical markets in, editor(s)Raj Bawa, Gerald F. Audette, Israel Rubinstein , Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications, Pan Stanford Publishing, 2016, pp299 - 318, [Dania Movia, Craig Poland, Lang Tran, Yuri Volkov, Adriele Prina-Mello]Book Chapter, 2016, DOI
Bashir Mustafa Mohamed, Dania Movia, Anton Knyazev, Dominique Langevin, Anthony Mitchell Davies, Adriele Prina-Mello, Yuri Volkov, Citrullination as early-stage indicator of cell response to Single-Walled Carbon Nanotubes, Scientific Reports, 3, (1124), 2013, p1 - 7Journal Article, 2013, DOI
Anja Schinwald, Fiona A Murphy, Adriele Prina-Mello, Craig A Poland, Fiona Byrne, Dania Movia, James R Glass, Janet C Dickerson, David A Schultz, Chris E Jeffree, William Macnee, Ken Donaldson, The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma, Toxicological Sciences, 128, (2), 2012, p461 - 470Journal Article, 2012, DOI
Mahfoud, O.K., Rakovich, T.Y., Prina-Mello, A., Movia, D., Alves, F., Volkov, Y., Detection of ErbB2: Nanotechnological solutions for clinical diagnostics, RSC Advances, 4, (7), 2014, p3422-3442Review Article, 2014, DOI , TARA - Full Text
Singh, M., Movia, D., Mahfoud, O.K., Volkov, Y., Prina-Mello, A., Silver nanowires as prospective carriers for drug delivery in cancer treatment: An in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts, European Journal of Nanomedicine, 5, (4), 2013, p195-204Journal Article, 2013, DOI
Catherine A Schütz, Davide Staedler, Kieran Crosbie-Staunton, Dania Movia, Catherine Chapuis Bernasconi, Blanka Halamoda Kenzaoui, Adriele Prina-Mello, Lucienne Juillerat-Jeannere, Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles, International Journal of Nanomedicine, 9, 2014, p3481 - 3498Journal Article, 2014, DOI , TARA - Full Text

Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016Report
Gavigan-Imedio J.D., Movia D., Volkov Y., Prina-Mello A., Nanomedicine translational oncology: a perspective to cancer treatment, EuroNanoForum, Dublin, Ireland, June 2013, 2013Oral Presentation
Movia D., Del Canto E., Giordani S., Purified and Oxidized SWNTs: potential NIR fluorescence probes for molecular imaging, ChemOnTubes 2010, Arcachon, France, 11-15/04/2010, 2010Oral Presentation

Research Expertise

Dr Dania Movia is a passionate advocate for transforming biomedical research by reducing and replacing animal testing through sustainable research and the education of young scientists on new preclinical technologies. Her work is driven by a commitment to advancing science in a more sustainable direction, focusing on the development of New Approach Methodologies (NAMs) designed to replace animal studies in the fields of lung cancer and lung toxicity research. As the founder and lead of the Humane Biomedical Research Group, Dr Movia has established Ireland's first wet-lab dedicated entirely to animal-free respiratory research. The lab's groundbreaking mission is to accelerate the translation of preclinical data into effective clinical treatments for patients with respiratory diseases - without the use of animal experimentation. Through this pioneering initiative, Dr Movia aims to foster long-term therapeutic responses, ensuring that innovations in research directly benefit patient care. Her efforts have garnered international recognition and substantial financial support, with over €23 million in research funding, including more than €2 million allocated directly to her as Principal Investigator. This funding comes from a wide array of prestigious national, European, and international organizations, including the Irish Research Council, Science Foundation Ireland, the Johns Hopkins Center for Alternatives to Animal Testing, Animal-Free Research UK, and the European Commission. Dr Movia's leadership in humane science is not only advancing the field but is also shaping the future of biomedical research by setting a new standard for ethical, innovative, and sustainable approaches to disease treatment. Research areas: 1. In vitro New Approach Methodologies (NAMs) 2. Alternatives to animal research and 3Rs principle 3. Lung cancer research 4. Inhalation toxicology 5. Oncological nanomedicine 6. Risk assessment of nanomaterials 7. Nanotechnology An up-to-date list of her publications can be found at: https://scholar.google.com/citations?user=T60uEacAAAAJ&hl=en&oi=ao

Title

Towards a kinder yet impactful way to conduct lung cancer research

Summary

Funding Agency

School of Medicine, Trinity College Dublin

Date From

2022

Date To

2023
Title

Developing in vitro non-animal methods (NAMs) for mimicking human lung tumour complexity

Summary

Funding Agency

Enterprise Ireland

Date From

2020

Date To

2021
Title

Photochromic Network Polymers and Supramolecular Modification of Single-Walled Carbon Nanotubes

Summary

Funding Agency

Irish Research Council

Date From

2008

Date To

2012
Title

Capturing human tumour complexity in 3D lung cancer models for predicting drugs' efficacy in patient

Summary

Funding Agency

Enterprise Ireland

Date From

2018

Date To

2018
Title

Extracellular vesicles in Non-Small-Cell Lung Cancer - Finding allies among the enemies

Summary

Funding Agency

Science Foundation Ireland

Date From

2022

Date To

2026
Title

INEDITED - Improve NanomEDIcine Translation into clinical lung cancEr Drugs

Summary

Funding Agency

Irish Research Council

Date From

2015

Date To

2017
Title

Risk Management of Biomaterials (BIORIMA)

Summary

Funding Agency

European Union

Date From

2017

Date To

2022
Title

Developing novel inhaled bioengineered Extracellular Vesicle RNA based advanced therapeutics, delivered by tailored aerosol delivery technology for the treatment of lung cancer (INSPIRE)

Summary

Funding Agency

European Commission

Date From

2022

Date To

2025
Title

Pre-clinical models for predicting the toxicity, absorption and biodistribution of inhaled nanomaterials in humans

Summary

Funding Agency

Johns Hopkins University Center for Alternatives to Animal Testing (CAAT)

Date From

2018

Date To

2020

Pharmacology and pharmaceutical sciences, Nanotechnology, Cancer,

Recognition

Best Material Science Poster, 33rd Annual Microscopy Society of Ireland (MSI) meeting 2009
Paper of the Year 2012, Society of Toxicology Board 2012
Research Award in recognition for the publication of an internationally peer-reviewed publication of the highest quality. 2012

Irish Lung Cancer Alliance (ILCA) member Present
Cancer Trials Ireland membership Present
EACR (European Association for Cancer Research) membership Present

Review Editor, Predictive Toxicology, specialty section of the Frontiers in Pharmacology journal. 2021
Guest Editor, Animals (MDPI) journal - Topic title: Replacing Animal Testing in Research"A Scientific and Regulatory Perspective of Current Efforts Towards the 1R. 2021
Scientific Advisory Panel member, Animal-Free Research UK. 2019
Topic Editor for the Frontiers in Bioengineering and Biotechnology journal (Topic: Use of 3D Models in Drug Development and Precision Medicine: Advances and Outlook). 2019
Scientific Advisory Panel member, FRAME UK 2021
Reviewer for several international scientific journals. A list is available at: http://www.webofscience.com/wos/author/record/T-6552-2018 Present