Professor Sarah Doyle

• Campbell, M., Doyle, S., Humphries, P. , IL-18: A new player in immunotherapy for age-related macular degeneration?, Expert Review of Clinical Immunology, 10, (10), 2014, p1273-1275Journal Article, 2014, DOI
• Campbell, M., Doyle, S.L., Ozaki, E., (...), Humphries, M.M., Humphries, P. , An overview of the involvement of interleukin-18 in degenerative retinopathies., Advances in experimental medicine and biology, 801, 2014, p409-415Journal Article, 2014, DOI
• Ozaki, E., Campbell, M., Kiang, A.S., (...), Doyle, S.L., Humphries, P. , Inflammation in age-related macular degeneration., Advances in experimental medicine and biology, 801, 2014, p229-235Journal Article, 2014, DOI
• Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG, TRAM is required for TLR2 endosomal signaling to type I IFN induction., Journal of immunology (Baltimore, Md. : 1950), 193, (12), 2014, p6090-102Journal Article, 2014, DOI , TARA - Full Text
• Ozaki E, Campbell M, Doyle S.L, Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives, Journal of Inflammation Research, 8, 2015, p15 - 27Journal Article, 2015, DOI , URL , TARA - Full Text
• Doyle S.L, Adamson P, López F.J, Humphries P, Campbell M, Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration, Nature Medicine, 20, (12), 2014, p1376 - 1377Journal Article, 2014, DOI , URL
• Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors. in, Toll Like receptors, 2016, pp65-77 , [Husebye H, Doyle SL]Book Chapter, 2016, DOI
• Doyle SL, López FJ, Humphries P, Adamson P, Campbell M, Author Response: The Role of IL-18 in the Treatment of AMD., Invest Ophthalmol Vis Sci, 56, (3), 2015, p8237-8Journal Article, 2015, DOI
• Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M, IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates., Invest Ophthalmol Vis Sci, 56, (9), 2015, p5424-30Journal Article, 2015, DOI
• Celkova L, Doyle SL, Campbell M, NLRP3 Inflammasome and Pathobiology in AMD., J. Clin. Med. , 4, (1), 2015, p172-192Journal Article, 2015, DOI , TARA - Full Text
• Yuan H, Wilson CM, Xia J, Doyle SL, Li S, Fales AM, Liu Y, Ozaki E, Mulfaul K, Hanna G, Palmer GM, Wang LV, Grant GA, Vo-Dinh T, Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor., 2014Journal Article, 2014
• Theodoropoulou S, Copland D.A, Liu J, Wu J, Gardner P.J, Ozaki E, Doyle S.L, Campbell M, Dick A.D, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye, Journal of Pathology, 241, (1), 2017, p45 - 56Journal Article, 2017, DOI , URL
• Gray P, Dunne A, Brikos C, Jefferies C.A, Doyle S.L, O'Neill L.A.J, Erratum: MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction (Journal of Biological Chemistry (2006) 281 (10489-10495) DOI: 10.1074/jbc.M508892200), Journal of Biological Chemistry, 291, (50), 2016, p26240-Journal Article, 2016, DOI , URL
• Immunobiology of Age-related macular degeneration in, Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2017, pp1 - 6, [Ufret-Vincenty, R.L., Doyle, S.L.]Book Chapter, 2017
• Connolly E, Rhatigan M, O'Halloran AM, Muldrew KA, Chakravarthy U, Cahill M, Kenny RA, Doyle SL., Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population, British Journal of Ophthalmology, 102, (12), 2018, p1691 - 1695Journal Article, 2018, DOI , URL
• Kiva Brennan, Bobby D. O"Leary, Danielle Mc Laughlin, Eamon P. Breen, Emma Connolly, Nusrat Ali, David N. O"Driscoll, Ema Ozaki, Rebecca Mahony, Kelly Mulfaul, Aoife M. Ryan, Aine Ni Chianain, Alison McHugh, Eleanor J. Molloy, Andrew E. Hogan, Sri Paran, Fionnuala M. McAuliffe, Sarah L. Doyle, Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation, The Journal of Immunology, 2018, pji1700956Journal Article, 2018
• Toll-Like Receptors and Age-Related Macular Degeneration in, Retinal Degenerative Diseases, 2018, pp19--28 , [Kelly Mulfaul, Maedbh Rhatigan, Sarah Doyle]Book Chapter, 2018
• 7. S Doyle, PS Adamson, FJ Lopez, P Humphries, M Campbell , IL-18 promotes wound healing and has anti-angiogenic properties in the eye., Investigative Ophthalmology & Visual Science, ARVO, Orlando, 56 (7), , 2014, pp2462-2462Conference Paper, 2014
• Campbell, M. and Doyle, S.L., Current perspectives on established and novel therapies for pathological neovascularization in retinal disease, Biochemical Pharmacology, 164, 2019, p321-325Journal Article, 2019, DOI , URL
• Brennan, K. and O'Leary, B.D. and Mc Laughlin, D. and Kinlen, D. and Molloy, E.J. and Cody, D. and Paran, S. and McAuliffe, F.M. and Hogan, A.E. and Doyle, S.L., Nucleic acid cytokine responses in obese children and infants of obese mothers, Cytokine, 119, 2019, p152-158Journal Article, 2019, DOI , URL
• Brennan, K. and Lyons, C. and Fernandes, P. and Doyle, S. and Houston, A. and Brint, E., Engagement of Fas differentially regulates the production of LPS-induced proinflammatory cytokines and type I interferons, FEBS Journal, 286, (3), 2019, p523-535Journal Article, 2019, DOI , URL
• Fahey, E. and Doyle, S.L., IL-1 family cytokine regulation of vascular permeability and angiogenesis, Frontiers in Immunology, 10, (JUN), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• CHAPTER 14: Biologicals in Retinal Therapy in, Therapies for Retinal Degeneration:Targetting common Processes, 2018, pp230-255 , [Connolly, E. and Doyle, S.L.]Book Chapter, 2018, DOI , URL
• Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT., Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction., Nature communications, 10, (1), 2019, p4003Journal Article, 2019, DOI , TARA - Full Text
• Brint, E. and Kamradt, T. and Doyle, S.L., Editorial: IL-1 Family Members in Health and Disease, Frontiers in Immunology, 10, (2596), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Ui Mhaonaigh, A. and Coughlan, A.M. and Dwivedi, A. and Hartnett, J. and Cabral, J. and Moran, B. and Brennan, K. and Doyle, S.L. and Hughes, K. and Lucey, R. and Floudas, A. and Fearon, U. and McGrath, S. and Cormican, S. and De Bhailis, A. and Molloy, E.J. and Brady, G. and Little, M.A., Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies, Frontiers in Immunology, 10, (2603), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Hudson, N. and Celkova, L. and Hopkins, A. and Greene, C. and Storti, F. and Ozaki, E. and Fahey, E. and Theodoropoulou, S. and Kenna, P.F. and Humphries, M.M. and Curtis, A.M. and Demmons, E. and Browne, A. and Liddie, S. and Lawrence, M.S. and Grimm, C. and Cahill, M.T. and Humphries, P. and Doyle, S.L. and Campbell, M., Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy, JCI Insight, 4, (15), 2019, p130273-Journal Article, 2019, DOI , URL , TARA - Full Text
• Ozaki, Ema, Gibbons, Luke, Neto, Nuno GB, Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew and Doyle, Sarah L, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL., Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration., Cell reports, 30, (7), 2020, p2209-2224.e5Journal Article, 2020, DOI , TARA - Full Text
• Wooff Y, Fernando N, Wong JHC, Dietrich C, Aggio-Bruce R, Chu-Tan JA, Robertson AAB, Doyle SL, Man SM, Natoli R., Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration., Scientific reports, 10, (1), 2020, p2263Journal Article, 2020, DOI , TARA - Full Text
• Useckaite Z, Ward MP, Trappe A, Reilly R, Lennon J, Davage H, Matallanas D, Cassidy H, Dillon ET, Brennan K, Doyle SL, Carter S, Donnelly S, Linnane B, McKone EF, McNally P, Coppinger JA., Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis., Thorax, 75, (6), 2020, p449-458Journal Article, 2020, DOI , TARA - Full Text
• Duignan S, Doyle SL, McMahon CJ., Refractory Kawasaki disease: diagnostic and management challenges., Pediatric health, medicine and therapeutics, 10, 2019, p131-139Journal Article, 2019, DOI
• Elizabeth Brint, Sarah Doyle and Thomas Kamradt , IL-1 family members in health and disease, 2019, DOI 10.3389/978-2-88963-241-1ppBook, 2019, TARA - Full Text
• Sarah Doyle, Ed Lavelle, Kieran Meade, Ciaran Harte, 'Vaccine Adjuvants', EPO, 2018Patent, 2018, URL
• Sarah Doyle, Matthew Campbell, Pete Humphries, Luke O'Neill,, 'Composition and Methods for the treatment of retinal degenerative disease', European Patent Office, EP2760465, 2020Patent, 2020, URL
• 1. Doyle S, Mulfaul K, Fernando N, Chirco K, Connolly E, Ryan T, Ozaki E, Brennan K, Maminishkis A, Salomon R, Natoli R., TLR2 bridges oxidative damage and complement-associated pathology and is a therapeutic target for age-related macular degeneration, Investigative Ophthalmology & Visual Science. 2018 Jul 13;59(9):3475, 2018Poster, 2018
• 2. Hudson N, Celkova L, Doyle S, Campbell M, Aberrant BMAL1 dependent claudin-5 cycling induces geographic atrophy, Investigative Ophthalmology & Visual Science. 2018 Jul 13;59(9):3469-., 2018Poster, 2018
• 3. Chen M, Augustine J, Pavlou S, Ali I, Doyle S, Stitt AW, Campbell M, Xu H., Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment., . Investigative Ophthalmology & Visual Science. 2018 Jul 13;59(9):3942-., 2018Poster, 2018
• 4. Skipor-Lahuta, Janina, et al., "Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers." , Fluids and Barriers of the CNS 14.Suppl 2 (2017)., 2017Poster, 2017
• 7. Theodoropoulou S, Doyle S, Copland D, Liu J, Wu J, Campbell M, Dick AD. Role of interleukin 33 in neovascular age-related macular degeneration, . Role of interleukin 33 in neovascular age-related macular degeneration, The Lancet. 2016 Feb 25;387:S99., 2016Poster, 2016
• 8. Theodoropoulou, S. , Doyle, S. , Copland, D. , Liu, J. , Wu, J. , Campbell, M. and Dick, A., ), Interleukin 33/ST2 signaling regulates inflammatory response in choroidal stroma and ocular angiogenesis: implications for age‐related macular degeneration, Acta Ophthalmol, 93:. doi:10.1111/j.1755-3768.2015.0453, 2015Poster, 2015
• Sarah Doyle Matthew Campbell Lucia Celkova Natalie Hudson, 'Novel strategies for treating age-related macular degeneration', EPO, 18174947.4 , 2016Patent, 2016, URL
• Delaney, C. and Farrell, M. and Doherty, C.P. and Brennan, K. and O†Keeffe, E. and Greene, C. and Byrne, K. and Kelly, E. and Birmingham, N. and Hickey, P. and Cronin, S. and Savvides, S.N. and Doyle, S.L. and Campbell, M., Attenuated CSF-1R signalling drives cerebrovascular pathology, EMBO Molecular Medicine, 13, (2), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Doyle, S.L., The Persistence of Privilege for a Healthy Retina, Immunity, 53, (2), 2020, p240-242Journal Article, 2020, DOI , URL
• Harford, D.A. and Delaney, C. and O'Callaghan, J. and Hudson, N. and Connolly, R. and Doyle, S. and Farrell, M. and Doherty, C.P. and Cahill, M. and Campbell, M., Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo- Drusen?, Ophthalmic Surgery Lasers and Imaging Retina, 52, (12), 2021, p666-671Journal Article, 2021, DOI , URL
• Brennan, K, Craven, S., Cheung, M, Kane, D., Noone, E., O'Callaghan, J., Molloy, E.J., Walsh, P.T., McAuliffe, F.,Doyle, S.L. , Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines., Journal of Leukocyte Biology, 2022Journal Article, 2022, DOI , TARA - Full Text
• Gibbons, L. and Ozaki, E. and Greene, C. and Trappe, A. and Carty, M. and Coppinger, J.A. and Bowie, A.G. and Campbell, M. and Doyle, S.L., SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration, Frontiers in Neuroscience, 16, (852114), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Ozaki, E. and Delaney, C. and Campbell, M. and Doyle, S.L., Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration, Experimental Eye Research, 217, (108953), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Mulfaul, K. and Doyle, S.L., In vitro measurement of membrane attack complex in RPE cells, Bio-protocol, 11, (4), 2021Journal Article, 2021, DOI , URL
• Doyle, S.L. and Shirey, K.A. and McGettrick, A.F. and Kenny, E.F. and Carpenter, S. and Caffrey, B.E. and Gargan, S. and Quinn, S.R. and Caamaño, J.H. and Moynagh, P. and Vogel, S.N. and Neill, L.A.O., Nuclear factor κb2 p52 protein has a role in antiviral immunity through IκB kinase ε-dependent induction of Sp1 protein and interleukin 15, Journal of Biological Chemistry, 288, (35), 2013, p25066-25075Journal Article, 2013, DOI , URL
• Palsson-McDermott, E.M. and Doyle, S.L. and McGettrick, A.F. and Hardy, M. and Husebye, H. and Banahan, K. and Gong, M. and Golenbock, D. and Espevik, T. and O'Neill, L.A.J., TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway, Nature Immunology, 10, (6), 2009, p579-586Journal Article, 2009, DOI , URL
• Kelly, A.M. and Leech, J.M. and Doyle, S.L. and McLoughlin, R.M., Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation, PLoS Pathogens, 18, (7), 2022Journal Article, 2022, DOI
• Corey TM, Woodley VV, O'Connor M, Connolly E, Doyle S, Shrader S, Phipps C, Isaac K, Lawrence M., Evaluation of the Dose-Dependent Inflammatory Response and No-Observable Adverse Effect Level of Intravitreal Endotoxin in the African Green Monkey. , Transl Vis Sci Technol., 2022Journal Article, 2022, DOI
• Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, J Biol Chem., 280, (25), 2005, p23496 - 23501Journal Article, 2005, DOI , URL , TARA - Full Text
• Millar, J. and Ozaki, E. and Campbell, S. and Duckett, C. and Doyle, S. and Cole, L.M., Multiomic Mass Spectrometry Imaging to Advance Future Pathological Understanding of Ocular Disease, Metabolites, 12, (12), 2022Journal Article, 2022, DOI , URL
• Killeen, S.L. and Mealy, G. and Brennan, K. and Cotter, P.D. and Yelverton, C. and Saldova, R. and Groeger, D. and VanSinderen, D. and Doyle, S. and McAuliffe, F.M., Impact of Bifidobacterium longum1714® on maternal cytokine response in peripheral blood mononuclear cells, Cytokine, 174, (156458), 2024Journal Article, 2024, DOI , URL
• Millar, J. and Gibbons, L. and Costa, C. and Schneider, E. and von Gerichten, J. and Bailey, M.J. and Campbell, S. and Duckett, C. and Doyle, S. and Cole, L.M., Multimodal Imaging of Metals in a Retinal Degeneration Model to Inform on Ocular Disease, Analytica, 4, (3), 2023, p264-279Journal Article, 2023, DOI , URL
• Millar, J. and Campbell, S. and Duckett, C. and Doyle, S. and Cole, L.M., MALDI and Trace Metal Analysis in Age-Related Macular Degeneration, Methods in Molecular Biology, 2688, 2023, p1-13Journal Article, 2023, DOI , URL
• Emma Connolly, Silvin P. Knight, Eoin Duggan, Siobhan Scarlett, Louise Newman, Mark Cahill, Rose Anne Kenny, Sarah L. Doyle, Roman Romero-Ortuno, Cardiovascular autonomic function and progression of age-related macular degeneration in The Irish Longitudinal Study of Ageing (TILDA), Investigative Ophthalmology & Visual Science, 2024Journal Article, 2024, DOI , TARA - Full Text
• Wooff, Y. and Fernando, N. and Wong, J.H.C. and Dietrich, C. and Aggio-Bruce, R. and Chu-Tan, J.A. and Robertson, A.A.B. and Doyle, S.L. and Man, S.M. and Natoli, R., Correction to: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration (Scientific Reports, (2020), 10, 1, (2263), 10.1038/s41598-020-58849-z), Scientific Reports, 14, (1), 2024Journal Article, 2024, DOI , URL
• Mealy, G. and Brennan, K. and Killeen, S.L. and Kilbane, M. and Yelverton, C. and Saldova, R. and Groeger, D. and VanSinderen, D. and Cotter, P.D. and Doyle, S.L. and McAuliffe, F.M., Impact of previous pregnancy and BMI on cellular and serum immune activity from early to late pregnancy, Scientific Reports, 14, (1), 2024Journal Article, 2024, DOI , URL
• Connolly, E. and El-Farouki, G. and Brennan, K. and Cahill, M. and Doyle, S.L., Poor Response to Bevacizumab Correlates With Higher IL-6 and IL-8 Aqueous Cytokines in AMD, Investigative ophthalmology & visual science, 65, (11), 2024, p37Journal Article, 2024, DOI , URL
• Silke, E. and Cahill, M. and Campbell, M. and Doyle, S.L., Inflammasomes in the pathobiology of degenerative retinopathies, 2022, 465-485ppBook, 2022, DOI , URL
• Doyle, SL and O'Neill LAJ, Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity, Biochem Pharmacol., 72, (9), 2006, p1102 - 1113Journal Article, 2006, DOI , URL
• Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O'Neill LA* and Hertzog P* , Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation, Nature Immunol., 7, (2), 2006, p148 - 155Journal Article, 2006, DOI , URL
• Doyle SL, Jefferies CA, Feighery C, O'Neill LA., Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase., Journal of Biological Chemistry, 282, (51), 2007, p36953-36960.Journal Article, 2007, DOI , TARA - Full Text
• Palsson-McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock , Espevik T and O'Neill LAJ, TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling, Nature Immunology, 10, 2009, p579 - 586Journal Article, 2009, DOI
• O'Neill LA, Bryant CE, Doyle SL, Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer., Pharmacological Reviews, 61, (2), 2009, p177-97Journal Article, 2009, DOI
• McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, (27), 2010, p20492-20498Journal Article, 2010, DOI , URL , TARA - Full Text
• Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction., The Journal of biological chemistry, 281, (15), 2006, p10489-95Journal Article, 2006, DOI
• Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, Crack PJ, Nicholson SE, Hilton DJ, O'Neill LA, Hertzog PJ, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation., Nature immunology, 7, (2), 2006, p148-55Journal Article, 2006, DOI
• Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4., The Journal of biological chemistry, 278, (28), 2003, p26258-64Journal Article, 2003, DOI
• Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928Journal Article, 2013, DOI , TARA - Full Text
• Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components., Nature medicine, 18, (5), 2012, p791-798Journal Article, 2012, DOI
• Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation., Nature communications, 3, 2012, p707Journal Article, 2012, DOI
• Campbell M, Doyle SL, An eye on the future of inflammasomes and drug development in AMD., Journal of molecular medicine (Berlin, Germany), 91, (9), 2013, p1059-70Journal Article, 2013, DOI
• Kenny, E.F., Quinn, S.R., Doyle, S.L., Vink, P.M., van Eenennaam, H., O'Neill, L.A.J., Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin, PLoS ONE, 8, (8), 2013, part. no. e74103Journal Article, 2013, DOI , TARA - Full Text
• Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA, Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15., J. Biol. Chem., 288, (35), 2013, p25066 - 25075Journal Article, 2013, TARA - Full Text
• Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-Journal Article, 2014, DOI , TARA - Full Text
• Doyle SL, Adamson P, López FJ, Humphries P, Campbell M, Interleukin-18 bioactivity and dose: data interpretation at a crossroads., Investigative ophthalmology & visual science, 55, (12), 2014, p8349-50Journal Article, 2014

• 1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016Conference Paper
• 3. Chen M, Augustine J, Pavlou S, Ali I, Doyle S, Stitt AW, Campbell M, Xu H, . Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment., . Investigative Ophthalmology & Visual Science. 2018 Jul 13;59(9):3942-., 2018Poster

Immunology, Other health sciences, Neurosciences,

• Novartis ICO Bursary Awardee 2014
• Trinity Technology transfer and innovation award nominee for "industry engagement" 2022
• Inaugral Irish Research Council (IRC) Laureate 2018
• Fritz Tobler Foundation Awardee, Retinal Degeneration (RD)2016 Sept 2016
• ARVO/Genetech AMD Basic Research Fellowship 2015
• Keystone Symposium Scholarship 2009
• Elected Fellow of Trinity College Dublin 2020
• Royal Academy of Medicine Ireland (RAMI) Research paper award winner Ophthalmology section November 2019
• Provosts Award, TCD, a competitive research award given by the president of TCD 2019
• Scince Foundation Ireland (SFI) Career Development Award recipient 2016
• International Society for Eye Research (ISER) Travel awardee 2016
• Researcher Highlight in Provost Review Annual 2014
• SFI STTF Travel Fellowship Award 2008
• ICIS Milstein Young Investigator Award recipient 2019
• TCD Technology transfer and innovation award "one-to-watch" winner 2020
• TCD Technology transfer and innovation "one-to-watch" nominee 2018
• Inaugral Pathfinder awardee 2015

• Irish Society of Immunology
• Association for Research in Vision and Ophthalmology
• International Society of Eye Research (ISER)
• Immunology Research Forum (IRF)
• International Cytokine and Interferon Society (ICIS)
• Immunometabolism Forum (IMF)
• Member of the Editorial Advisory Board for The Journal of Biochemical Pharmacology present

• Member of the Editorial Advisory Board for Biochemical Pharmacology.