Medicine

Contact Us School of Medicine
Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

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Professor Ross Mc Manus

Professor Ross Mc Manus

Professor in Molecular Medicine


Publications and Further Research Outputs

  • Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J, Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus., Gastroenterology, 148, (2), 2015, p367-78Journal Article, 2015, DOI , TARA - Full Text
  • Bowes, J. Budu-Aggrey, A. Huffmeier, U. Uebe, S. Steel, K. Hebert, H.L. Wallace, C. Massey, J. Bruce, I.N. Bluett, J. Feletar, M. Morgan, A.W. Marzo-Ortega, H. Donohoe, G. Morris, D.W. Helliwell, P. Ryan, A.W. Kane, D. Warren, R.B. Korendowych, E. Alenius, G.-M. Giardina, E. Packham, J. McManus, R. Fitzgerald, O. McHugh, N. Brown, M.A. Ho, P. Behrens, F. Burkhardt, H. Reis, A. Barton, A., Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis, Nature Communications, 6, 2015, p6046-Journal Article, 2015, DOI , URL , TARA - Full Text
  • Coleman C, Quinn E.M, Ryan A.W, Conroy J, Trimble V, Mahmud N, Kennedy N, Corvin A.P, Morris D.W, Donohoe G, O'Morain C, MacMathuna P, Byrnes V, Kiat C, Trynka G, Wijmenga C, Kelleher D, Ennis S, Anney R.J.L, McManus R, Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci, European Journal of Human Genetics, 24, 2016, p291 - 297Journal Article, 2016, DOI , URL , TARA - Full Text
  • Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., The Journal of allergy and clinical immunology, 2015Journal Article, 2015, DOI , TARA - Full Text
  • Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22Journal Article, 2016, DOI
  • Quinn EM, McManus R, Quality Control and Analysis of NGS RNA Sequencing Data., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p217-32Journal Article, 2015, DOI
  • Coleman C, Quinn EM, McManus R, Quality Control Procedures for High-Throughput Genetic Association Studies., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p203-15Journal Article, 2015, DOI
  • Molloy B, Freeley M, Long A, McManus R, Candidate Gene Knockdown in Celiac Disease., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p159-73Journal Article, 2015, DOI
  • Molloy B, McManus R, Cloning Gene Variants and Reporter Assays., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p117-30Journal Article, 2015, DOI
  • Quinn EM, Coleman C, Molloy B, Dominguez Castro P, Cormican P, Trimble V, Mahmud N, McManus R, Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFN" Regulation., PloS One, 10, (10), 2015, pe0140049Journal Article, 2015, DOI , TARA - Full Text
  • Bowes J, Loehr S, Budu-Aggrey A, Uebe S, Bruce IN, Feletar M, Marzo-Ortega H, Helliwell P, Ryan AW, Kane D, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, Brown MA, Behrens F, Burkhardt H, McHugh N, Huffmeier U, Ho P, Reis A, Barton A., PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus, Annals of the Rheumatic Diseases, 74, 2015, p1882 - 1885Journal Article, 2015, DOI , TARA - Full Text
  • Candidate Gene Knockdown in Celiac Disease. in, Methods in Molecular Biology, 2015, pp159 - 173, [Molloy B, Freeley M, Long A, McManus R]Book Chapter, 2015, URL
  • Eleanor Molloy, Michelle Walsh, Response, J Perinatol, 25, (5), 2005, p360--360Journal Article, 2005
  • Windle HJ*, Ang YS*, Athie Morales V, McManus R*, Kelleher DP , Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals, Gut, 54, (1), 2005, p25 - 32Journal Article, 2005, DOI , TARA - Full Text
  • Kelly E, Sievers F, McManus R. , Haplotype frequency estimation error analysis in the presence of missing genotype data., BMC Bioinformatics, 5, (1), 2004, p188 - 203Journal Article, 2004, DOI
  • Ryan AW, Thornton JM, Brophy K, Daly JS, O' Morain C, McLoughlin RM, Kennedy NP, Abuzakouk M, Stevens FM, Feighery C, Kelleher D, McManus R. , Haplotype variation at the IBD5 locus (5q31) in coeliac disease in the Irish population. , Tissue Antigens, 64, (2), 2004, p195 - 198Journal Article, 2004, DOI
  • Arnott IDR, Nimmo ER, Drummond HE, Fennell J, Smith BR, MacKinlay E, Morecroft J, Anderson N, O'Sullivan M, O'Morain C, Kelleher D, McManus R, Satsangi J., NOD2/CARD15, TLR4 and CD14 Mutations in Scottish and Irish Patients with Crohn's disease: Evidence for Genetic Heterogeneity within Europe., Genes and Immunity, 5, (5), 2004, p417 - 425Journal Article, 2004, DOI
  • Goulding C, McManus R, Murphy A, MacDonald GS, Barrett S, Crowe J, Hegarty J, McKiernan S, Kelleher D., The CCR5-delta32 Mutation- Impact on disease outcome in individuals with hepatitis C infection from a single source, Gut, 54, (8), 2005, p1157 - 1161Journal Article, 2005, DOI
  • Ryan BM, Molloy AM, McManus R, Arfin Q, Kelleher D, Scott JM, Weir DG. , The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: Role in tumor development and significance of allelic loss in tumor progression , International Journal of Gastrointestinal Cancer , 30, (3), 2001, p105 - 111Journal Article, 2001, DOI
  • ID Arnott, ER Nimmo, HE Drummond, J Fennell, BR Smith, E MacKinlay, J Morecroft, N Anderson, D Kelleher, M O'Sullivan, R McManus, J Satsangi, NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: Evidence for genetic heterogeneity within Europe? , Genes and Immunity, 5, 2004, p417 - 425Journal Article, 2004
  • Duggan, E., Caraher, E., Gately, K., O'Dwyer, M., McGovern, E., Kelleher, D., McManus, R., Ryan, T., Tumor necrosis factor-" and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery, Critical Care Medicine, 34, (8), 2006, p2134-2139Journal Article, 2006
  • Mahabeleshwar, G., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z., Haldar, S., Atkins, G., Wong, H., Lingrel, J., Jain, M., The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock, Immunity, 34, (5), 2011, p715-728Journal Article, 2011
  • Mahabeleshwar, G.H., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z., Haldar, S.M., Atkins, G.B., Wong, H.R., Lingrel, J.B., Jain, M.K., The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock, Immunity, 35, (1), 2011Journal Article, 2011
  • Ryan, A.W., Hughes, D.A., Tang, K., Kelleher, D.P., Ryan, T., McManus, R., Stoneking, M., Natural selection and the molecular basis of electrophoretic variation at the coagulation F13B locus, European Journal of Human Genetics, 17, (2), 2009, p219-227Journal Article, 2009
  • O'Dwyer, M.J., Mankan, A.K., Ryan, A.W., Lawless, M.W., Stordeur, P., Kelleher, D., McManus, R., Ryan, T., Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis, International Journal of Immunogenetics, 35, (4-5), 2008, p279-285Journal Article, 2008
  • Ryan AW, Thornton JM, Brophy K, Daly JS, McLoughlin RM, O' Morain C, Abuzakouk M, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R., Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1., Tissue Antigens, 65, (2), 2005, p150 - 155Journal Article, 2005, DOI
  • Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338Journal Article, 2016, DOI , URL
  • Budu-Aggrey A, Bowes J, Loehr S, Uebe S, Zervou M.I, Helliwell P, Ryan A.W, Kane D, Korendowych E, Giardina E, Packham J, McManus R, Fitzgerald O, McHugh N, Behrens F, Burkhardt H, Huffmeier U, Ho P, Martin J, Castañeda S, Goulielmos G, Reis A, Barton A, Replication of a distinct psoriatic arthritis risk variant at the IL23R locus, Annals of the Rheumatic Diseases, 75, (7), 2016, p1417 - 1418Journal Article, 2016, DOI , URL , TARA - Full Text
  • Radian S, Diekmann Y, Gabrovska P, Holland B, Bradley L, Wallace H, Stals K, Bussell AM, McGurren K, Cuesta M, Ryan AW, Herincs M, Hernández-Ramírez LC, Holland A, Samuels J, Aflorei ED, Barry S, Dénes J, Pernicova I, Stiles CE, Trivellin G, McCloskey R, Azjensztejn M, Abid N, Akker SA, Mercado M, Cohen M, Thakker RV, Baldeweg S, Barkan A, Musat M, Levy M, Orme S, Unterländer M, Burger J, Kumar AV, Ellard S, McPartlin J, McManus R, Linden GJ, Atkinson B, Balding D, Agha A, Thompson CJ, Hunter SJ, Thomas MG, Morrison PJ, Korbonits M., Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland, Human Mutation, 2017, p78-85Journal Article, 2017, DOI , TARA - Full Text
  • Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert H.L, Wallace C, Massey J, Bruce I.N, Bluett J, Feletar M, Morgan A.W, Marzo-Ortega H, Donohoe G, Morris D.W, Helliwell P, Ryan A.W, Kane D, Warren R.B, Korendowych E, Alenius G.-M, Giardina E, Packham J, McManus R, Fitzgerald O, McHugh N, Brown M.A, Ho P, Behrens F, Burkhardt H, Reis A, Barton A, Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis (Nature Communications (2015) 6 (6046) DOI:10.1038/ncomms7046), Nature Communications, 6, 2015Journal Article, 2015, DOI , URL
  • Dominguez Castro P, Harkin G, Hussey M, Christopher B, Kiat C, Chin JL, Trimble V, McNamara D, MacMathuna P, Egan B, Ryan B, Kevans D, Farrell R, Byrnes V, Mahmud N, McManus R. , Changes in Presentation of Celiac Disease in Ireland From the 1960s to 2015, Clinical Gastroenterology and Hepatology, 15, (1), 2017, p864 - 871Journal Article, 2017, DOI
  • Bowes J, Ashcroft J, Dand N, Jalali-najafabadi F, Bellou E, Ho P, Marzo-Ortega H, Helliwell P, Feletar M, Ryan A, Kane D, Korendowych E, Simpson M, Packham J, McManus R, Brown M, Smith C, Barker J, McHugh N, FitzGerald O, Warren R, Barton A. , Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis , Annals of Rheumatic Diseases, 76, (10), 2017, p1774 - 1779Journal Article, 2017, DOI , TARA - Full Text
  • Romero-Ortuno R, Kenny RA, McManus R, Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans, Experimental Gerontology, 129, 2019, p110781 -Journal Article, 2019, DOI , URL
  • Coakley JD, Breen EP, Moreno-Olivera A, Al-Harbi AI, Melo AM, O'Connell B, McManus R, Doherty DG, Ryan T., Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis, PLoS One, 14, (10), 2019, pe0224276-Journal Article, 2019, DOI
  • Castro P.D., Harkin G., Hussey M., Christopher B., Kiat C., Chin J.L., Trimble V., McNamara D., MacMathuna P., Egan B., Ryan B., Kevans D., Abuzakouk M., Farrell R., Feighery C., Byrnes V., Mahmud N., McManus R., Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing, United European Gastroenterology Journal, 8, (2), 2020, p148 - 156Journal Article, 2020, DOI
  • Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Deirdre McNamara, Padraic MacMathuna, Brian Egan, David Kevans, Richard Farrell, Valerie Byrnes, Ross McManus, A Description of the clinical phenotype of coeliac disease in Ireland; Cross-sectional Study and 55 Year Perspective., Gastroenterology, American Gastroenterology Society/ Digestive Disease Week, San Diego, California, USA, 25 May 2016, 150, (4), Elsevier , 2016, ppS-205 - S-206Oral Presentation, 2016, DOI , URL
  • A. Budu-Aggrey, J. Bowes, S. Lohr, S. Uebe, M.I. Zervou, P. Helliwell, A.W. Ryan, D. Kane, E. Korendowych, E. Giardina, J. Packham, R. McManus, O. FitzGerald, N. McHugh, F. Behrens, H. Burkhardt, U. Huffmeier, P. Ho, J. Martin, S. Castañeda, G. Goulielmos, A. Reis, A. Barton, Replication of A Distinct Psoriatic Arthritis Risk Variant at IL23R, Annals of the Rheumatic Diseases, EULAR - Annual European Congress of Immunology, Frankfurt, Germany, 3 June 2016, 75, (S2), BMJ Journals, 2016, pp667 - 668Poster, 2016, DOI
  • Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Jun Liong Chin, Deirdre McNamara, Padraic MacMathuna, Brian J. Egan, Barbara Ryan, David Kevans, Richard Farrell, Valerie Byrnes, Ross McManus, Pattern of Thyroid Disease Presentation in a Cohort of Celiac Patients Diagnosed from 1960-2015, Gastroenterology, American Gastroenterology Society/ Digestive Disease Week, Chicago, IL, USA, 7 May 2017, 152, (5), Elsevier , 2017, ppS484 - S484Poster, 2017, DOI
  • Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Jun Liong Chin, Deirdre McNamara, Padraic MacMathuna, Brian J. Egan, Barbara Ryan, David Kevans, Richard Farrell, Valerie Byrnes, Ross McManus, Co-Existence of Celiac Disease and other Immune-Mediated Conditions in Celiac Patients, Gastroenterology, American Gastroenterology Society/ Digestive Disease Week, Chicago, IL, USA, 7 May 2017, 152, (5), Elsevier , 2017, ppS483 - S484Poster, 2017, DOI
  • Ryan BM, Lefort L, McManus R, Daly J, Keeling PW, Weir DG, Kelleher D, A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up, Gut, 52, (1), 2003, p101-108Journal Article, 2003, DOI , TARA - Full Text
  • Ryan BM, McManus R, Daly JS, Keeling NWP, Weir DG, Lefort F, Kelleher D, Serum mutant K-ras in the colorectal adenoma-to-carcinoma sequence. Implications for diagnosis, postoperative follow-up, and early detection of recurrent disease, Annals of the New York Academy of Sciences, 906, 2000, p29-30Journal Article, 2000, URL
  • L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90Journal Article, 1997, DOI
  • R. McManus, M. Moloney, M. Borton, A. Finch, Y. T. Chuan, E. Lawlor, D. G. Weir and D. Kelleher, Association of celiac disease with microsatellite polymorphisms close to the tumor necrosis factor genes, Human Immunology, 45, (1), 1996, p24-31Journal Article, 1996, DOI
  • B. M. Ryan, R. McManus, J. S. Daly, E. Carton, P. W. Keeling, J. V. Reynolds and D. Kelleher, A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma, British Journal of Cancer, 85, (10), 2001, p1499-1503Journal Article, 2001, DOI
  • R. McManus, A. G. Wilson, J. Mansfield, D. G. Weir, G. W. Duff and D. Kelleher, TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype, European Journal of Immunology, 26, (9), 1996, p2113-2118Journal Article, 1996, DOI , URL
  • S. Lynch, D. Kelleher, R. McManus and C. O'Farrelly, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation, European journal of immunology, 25, (5), 1995, p1143-1147Journal Article, 1995, DOI
  • Lakhani SR, Gusterson BA, Jacquemier J, Sloane JP, Anderson TJ, van de Vijver MJ, Farid LM, Venter D, Freeman A, Antoniou A, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, McManus R, Scherneck S, Ponder BAJ,. Futreal PA, Peto J, Stoppa-Lyonnet D, BignonY-J, Struewing JP, Bishop DT, Klijn JGM, Devilee P, Cornelisse CJ, Lasset C, Lenoir G, Barkardottir RB, Egilsson V, Hamann U, Chang-Claude J, Sobol H, Weber B, Easton DF, Stratton MR , The Pathology of Familial Breast Cancer: Histological Features of Cancers in Families not due to Mutations in BRCA1 or BRCA2 , Cliniical Cancer Research, 6, (3), 2000, p782 - 789Journal Article, 2000, URL
  • Lakhani SR, Sloane JP, Gusterson BA, Anderson TJ, Jacquemier J, van de Vijver MJ, Farid LM, Venter D, Antoniou A, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, Mc Manus R, Scherneck S, Ponder BA, Ford D, Peto J, Stoppa-Lyonnet D, Stratton MR, Easton DF, et al. , Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations, Journal of the National Cancer Institute, 90, (15), 1998, p1138 - 1145Journal Article, 1998, URL
  • Easton D, Steele L, Fields P, Ormiston W, Averill D, Daly PA, Mc Manus R, Neuhausen SL, Ford D, Wooster R, Cannon-Albright LA, Stratton MR, Goldgar DE, Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12-13, American Journal of Human Genetics, 61, (1), 1997, p120 - 128Journal Article, 1997, URL
  • The Breast Cancer Linkage Consortium. (Lakhani SR, Sloane JP, Gusterson BA, Anderson TJ, Jacquemier J, van de Vijver MJ, Farid LM, Venter D, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, Mc Manus R, et al.), Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases, Lancet, 349, (9064), 1997, p1505 - 1510Journal Article, 1997, DOI
  • Wooster R, Neuhausen SL, Mangion J, Quirk Y, Ford D, Collins N, Nguyen K, Seal S, Tran T, Averill D, Fields P, Marshall G, Narod S, Lenoir GM, Lynch H, Feunteun J, Devilee P, Cornelisse CJ, Menko FH, Daly PA, Ormiston W, Mc Manus R, Pye C, Lewis CM, Cannon-Albright LA, Peto J, Ponder BAJ, Skolnick MH, Easton DF, Goldgar DE, Stratton MR, Localisation of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13, Science, 265, (5181), 1994, p2088 - 2090Journal Article, 1994, DOI
  • Stratton MR, Ford D, Neuhasen S, Seal S, Wooster R, Friedman LS, King MC, Egilsson V, Devilee P, Mc Manus R, Daly PA, Smyth E, Ponder BAJ, Peto, J, Cannon- Albright L, Easton DF, Goldgar DE, Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q, Nature Genetics, 7, (1), 1994, p103 - 107Journal Article, 1994, DOI
  • Collins N, Mc Manus R, Wooster R, Mangion J, Seal S, Lakhani SR, Ormiston W, Daly PA, Ford D, Easton DF, Stratton MR, Consistent loss of the wild type chromosome in breast cancers from BRCA2 gene carriers, Oncogene, 10, (8), 1995, p1673 - 1675Journal Article, 1995
  • Brophy K, Ryan AW, Thornton JM, Daly JS, McLoughlin R, O' Morain C, Abuzakouk M, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R, Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population., Genes and Immunity, 7, (1), 2006, p19 - 26Journal Article, 2006, DOI
  • Coakley J.D., Breen E., Moreno-Olivera A., Al-Harbi A., Melo A., O'Connell B., McManus R., Doherty D., Ryan T. , Innate lymphocyte Th1 and Th17 responses in elderly hospitalised patients with infection and sepsis., Vaccines, 8, (2), 2020, p311-Journal Article, 2020, DOI , URL
  • Ní Chonchubhair H.M., Duggan S.N., Egan S.M., Kenyon M., O'Toole D., McManus R., Conlon K.C. , A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland., HPB Journal, 2020Journal Article, 2020
  • Feighery, C.F. and McManus, R., Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on Nutrition and autoimmune disease, Proceedings of the Nutrition Society, 68, (2), 2009, p122-126Journal Article, 2009, DOI , URL
  • Mankan, A.K. and Lawless, M.W. and Gray, S.G. and Kelleher, D. and McManus, R., NF-κB regulation: The nuclear response, Journal of Cellular and Molecular Medicine, 13, (4), 2009, p631-643Journal Article, 2009, DOI , URL
  • Azim, K. and McManus, R. and Brophy, K. and Ryan, A. and Kelleher, D. and Reynolds, J.V., Genetic polymorphisms and the risk of infection following esophagectomy. Positive association with TNF-α gene -308 genotype, Annals of Surgery, 246, (1), 2007, p122-128Journal Article, 2007, DOI , URL
  • Windle, H.J. and Ang, Y.S. and Morales, V.A. and McManus, R. and Kelleher, D., Erratum: Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals (Gut (January 2005) 54 (25-32)), Gut, 54, (4), 2005, p568Journal Article, 2005, DOI , URL
  • Lakhani, S.R. and Gusterson, B.A. and Jacquemier, J. and Sloane, J.P. and Anderson, T.J. and Van De Vijver, M.J. and Venter, D. and Freeman, A. and Antoniou, A. and McGuffog, L. and Smyth, E. and Steel, C.M. and Haites, N. and Scott, R.J. and Goldgar, D. and Neuhausen, S. and Daly, P.A. and Ormiston, W. and McManus, R. and Scherneck, S. and Ponder, B.A.J. and Futreal, P.A. and Peto, J. and Stoppa-Lyonnet, D. and Bignon, Y.-J. and Struewing, J.P. and Bishop, D.T. and Klijn, J.G.M. and Devilee, P. and Cornelisse, C.J. and Lasset, C. and Lenoir, G. and Barkardottir, R.B. and Egilsson, V. and Hamann, U. and Chang-Claude, J. and Sobol, H. and Weber, B. and Easton, D.F. and Stratton, M.R., The pathology of familial breast cancer: Histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2, Clinical Cancer Research, 6, (3), 2000, p782-789Journal Article, 2000, URL
  • King, S. and Holleran, L. and Mothersill, D. and Patlola, S. and Rokita, K. and McManus, R. and Kenyon, M. and McDonald, C. and Hallahan, B. and Corvin, A. and Morris, D. and Kelly, J. and McKernan, D. and Donohoe, G., Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6, Brain, Behavior, and Immunity, 98, 2021, p388-396Journal Article, 2021, DOI , URL
  • Mothersill, D. and King, S. and Holleran, L. and Dauvermann, M. and Patlola, S. and Rokita, K. and McManus, R. and Keynon, M. and McDonald, C. and Hallahan, B. and Corvin, A. and Morris, D. and Kelly, J. and McKernan, D. and Donohoe, G., Interleukin 6 predicts increased neural response during face processing in a sample of individuals with schizophrenia and healthy participants: A functional magnetic resonance imaging study, NeuroImage: Clinical, 32, (102851), 2021Journal Article, 2021, DOI , URL
  • Wood, A. and Runciman, R. and Wylie, K.R. and McManus, R., An update on female sexual function and dysfunction in old age and its relevance to old age psychiatry, Aging and Disease, 3, (5), 2012, p373-384Journal Article, 2012, URL
  • HÃŒffmeier, U. and Uebe, S. and Ekici, A.B. and Bowes, J. and Giardina, E. and Korendowych, E. and Juneblad, K. and Apel, M. and McManus, R. and Ho, P. and Bruce, I.N. and Ryan, A.W. and Behrens, F. and Lascorz, J. and Böhm, B. and Traupe, H. and LohmaN, J. and Gieger, C. and Wichman, H.-E. and Herold, C. and Steffens, M. and Klareskog, L. and Wienker, T.F. and FitzGerald, O. and Alenius, G.-M. and McHugh, N.J. and Novelli, G. and Burkhardt, H. and Barton, A. and Reis, A., CoMon variants at TRAF3IP2 are aSociated with susceptibility to psoriatic arthritis and psoriasis, Nature Genetics, 42, (11), 2010, p996-999Journal Article, 2010, DOI , URL
  • Kenyon, M. and Maguire, S. and Rueda Pujol, A. and O†Shea, F. and McManus, R., The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease, Rheumatology International, 42, (12), 2022, p2085-2095Journal Article, 2022, DOI , URL
  • Soomro, M. and Stadler, M. and Dand, N. and Bluett, J. and Jadon, D. and Jalali-najafabadi, F. and Duckworth, M. and Ho, P. and Marzo-Ortega, H. and Helliwell, P.S. and Ryan, A.W. and Kane, D. and Korendowych, E. and Simpson, M.A. and Packham, J. and McManus, R. and Gabay, C. and Lamacchia, C. and Nissen, M.J. and Brown, M.A. and Verstappen, S.M.M. and Van Staa, T. and Barker, J.N. and Smith, C.H. and Chalmers, R. and Flohr, C. and Watson, K. and Prieto-Merino, D. and Alabas, O. and Barker, J. and Becher, G. and Bewley, A. and Burden, D. and Morrison, S. and Laws, P. and Evans, I. and Griffiths, C. and Ahmed, S. and Kirby, B. and Kleyn, E. and Lawson, L. and Mackenzie, T. and McPherson, T. and McElhone, K. and Murphy, R. and Ormerod, A. and Owen, C. and Reynolds, N. and Rashid, A. and Smith, C. and Warren, R. and Burden, D. and Smith, C. and Siebert, S. and Brown, S. and McAteer, H. and Schofield, J. and Dand, N. and FitzGerald, O. and McHugh, N. and Warren, R.B. and Bowes, J. and Barton, A., Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling, Arthritis and Rheumatology, 74, (9), 2022, p1535-1543Journal Article, 2022, DOI , URL
  • Shraim, R. and Macdonnchadha, C. and Vrbanic, L. and McManus, R. and Zgaga, L., Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research, Nutrients, 14, (13), 2022Journal Article, 2022, DOI , URL
  • Dring MM, Goulding CA, Trimble VI, Keegan D, Ryan AW, Brophy KM, Smyth CM, Keeling PWN, O'Donoghue D, O'Sullivan M, O'Morain C, Mahmud N, Wikström A-C, Kelleher D, McManus R., The Pregnane X Receptor Locus is Associated with susceptibility to inflammatory bowel disease., Gastroenterology, 130, (2), 2006, p341 - 348Journal Article, 2006, DOI
  • Duggan E, Caraher E, Gately C, O'Dwyer M, McGovern E, Kelleher D, McManus R, Ryan T, Tumour necrosis factor alpha and Interleukin10 gene expression after cardiac surgery: The protective role of Interleukin 10, Critical Care Medicine , 34, (8), 2006, p2134 - 2139Journal Article, 2006, DOI
  • Mattiangeli V, Ryan AW, McManus R, Bradley DG, A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population, Genome Biology, 7, (8), 2006, pR74-Journal Article, 2006, DOI
  • O'Dwyer MJ, Mankan AK, Stordeur P, O'Connell B, Duggan E, White M, Kelleher DP, McManus R, Ryan T, The occurrence of severe sepsis is related to distinct patterns of cytokine gene expression, Shock, 26, (6), 2006, p544 - 550Journal Article, 2006, DOI
  • Ryan R*, Thornton J*, Duggan E, McGovern E, O'Dwyer MJ, Ryan AW, Kelleher D, McManus R, Ryan T, Gene polymorphism and requirement for vasopressor infusion after cardiac surgery, Annals of Thoracic Surgery, 82, (3), 2006, p895 - 901Journal Article, 2006, DOI
  • Phillips CP, Lopez-Miranda J, Perez-Jimenez F, McManus R & Roche HM, Genetic and Nutrient Determinants of the Metabolic Syndrome, Current Opinion in Cardiology , 2, (3), 2006, p185 - 193Journal Article, 2006, DOI
  • O'Dwyer MJ, Dempsey F, Crowley V, Kelleher DP, McManus R, Ryan T., Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study., Critical Care, 10, (5), 2006, pR139Journal Article, 2006, DOI , TARA - Full Text
  • O'Dwyer MJ, Mankan AK, Stordeur P, O'Connell B, Duggan E, White M, Kelleher DP, McManus R, Ryan T., The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression., Shock, 26, (6), 2006, p544 - 550Journal Article, 2006
  • Duggan E, O'Dwyer M, Caraher E, Diviney D, McGovern E, Kelleher D, McManus R, Ryan T, Coagulopathy After Cardiac Surgery May Be Influenced by a Functional Plasminogen Activator Inhibitor Polymorphism, Anesthesia & Analgesia , 104, (6), 2007, p1343 - 1347Journal Article, 2007, DOI , TARA - Full Text
  • Zhao Y, Terron-Kwiatkowski A, Liao H, Lee SP, Allen MH, Hull PR, Campbell LE, Trembath RC, Capon F, Griffiths CE, Burden D, McManus R, Hughes R, Kirby B, Fitzgerald O, Kane D, Barker JN, Palmer CN, Irvine AD, McLean WHI , Filaggrin null alleles are not associated with psoriasis, Journal of Investigative Dermatology , 127, (8), 2007, p1878 - 1882Journal Article, 2007, DOI
  • Azim K, McManus R, Brophy K, Ryan A, Kelleher D, Reynolds JV, Genetic Polymorphisms and the Risk of Infection Following Esophagectomy , Annals of Surgery, 246, (1), 2007, p122 - 128Journal Article, 2007, DOI
  • van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, , A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21., Nature Genetics, 39, (7), 2007, p827 - 829Journal Article, 2007, DOI , TARA - Full Text
  • Ryan AW, Mapp J, Moyna S, Mattiangeli V, Kelleher D, Bradley DG, McManus R, Levels of inter-population differentiation among different functional classes of immunologically important genes, Genes and Immunity, 7, (2), 2006, p179 - 183Journal Article, 2006, DOI
  • O'Dwyer MJ, Dempsey F, Crowley V, Kelleher D, McManus R, Ryan T., Septic shock correlates with ADMA levels which may be influenced by a polymorphism in DDAH II: a prospective observational study, Critical Care, 10, (5), 2006, pR139 article numberJournal Article, 2006, DOI
  • O'Dwyer MJ, Mankan AK, Stordeur P, White W, Lawless MW, O'Connell B, Kelleher D, McManus R*, Ryan T* , Variability in IL-23 and IL-27 gene expression may determine patient response to a septic insult, Intensive Care Medicine, 34, (4), 2008, p683 - 691Journal Article, 2008, DOI
  • White M, Mankan A, Lawless MW, O'Dwyer MJ, McManus R, Ryan T, Mortality in humans with pneumonia and sepsis is related to an uncompensated anti-inflammatory response to infection, Archives of Internal Medicine, 168, (13), 2008, p1468 - 1469Journal Article, 2008, URL
  • Murphy G, Thornton J, McManus R, Swan N, Ryan B, Hughes D, O'Morain C, O'Sullivan M, Association of gastric disease with polymorphisms in the inflammatory related genes IL-1B, IL-1RN, IL-10, TNF and TLR4 , European Journal of Gastroenterology and Hepatology, 21, (6), 2009, p630-635Journal Article, 2009, DOI
  • Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA,Todd JA, Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease, New England Journal of Medicine, 359, (26), 2008, p2767 - 2777Journal Article, 2008, DOI
  • Mankan, A.K., Lawless, M.W., Gray, S.G., Kelleher, D., McManus, R., NF-κB regulation: The nuclear response , Journal of Cellular and Molecular Medicine , 13, (4), 2009, p631-643Journal Article, 2009, DOI , URL , TARA - Full Text
  • Romanos J, van Diemen CC, Nolte IM, Trynka G, Zhernakova A, Fu J, Bardella MT, Barisani D, McManus R, van Heel DA, Wijmenga C., Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease, Gastroenterology , 137, (133), 2009, p834-840Journal Article, 2009, DOI
  • Feighery CF, McManus R., Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease'. Recent advances in genetic understanding of coeliac disease. , Proceedings of the Nutrition Society, 68, (2), 2009, p122-126Journal Article, 2009, DOI , URL , TARA - Full Text
  • Szabo de Edelenyi F, Goumidi L, Bertrais S, Phillips C, MacManus R, Roche H, Planells R, Lairon D., Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest. , Genes and Nutrition, 3, (3-4), 2008, p173-176Journal Article, 2008, DOI
  • O'Dwyer MJ, Mankan AK, Stordeur P, White W, Lawless MW, O'Connell B, Kelleher D, McManus R*, Ryan T*. , The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression, Intensive Care Medicine, 34, (4), 2008, p683-691Journal Article, 2008, DOI
  • Ryan, A.W., O'Brien, E., Shields, D., McManus, R., Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample , Atherosclerosis , 196, (1), 2008, 465-466Journal Article, 2008, DOI
  • Mechanisms of steroid action and resistance in inflammatory bowel disease. in, editor(s)Jewell DP, Colombel, JF, Pena AS, Tromm A, Warren BS , Colitis: Diagnosis and Therapeutic Strategies, Falk Symposia, Kluwer Academic Publishers, 2006, pp87-97 , [Kelleher D, McManus R.]Book Chapter, 2006
  • Goulding, C., Murphy, A., MacDonald, G., Barrett, S., Crowe, J., Hegarty, J., McKiernan, S., (...), McManus, R. , Erratum: The CCR5-Ä32 mutation: Impact on disease outcome in individuals with hepatitis C infection from a single source (Gut (August 2005) 54 (1157-1161)), 2005, - 1508Miscellaneous, 2005, DOI
  • Kelleher D, Farrell R, McManus R., Pharmacogenetics of inflammatory bowel disease., Novartis Foundation Symposium - Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems, edited by Derek Chadwick, Jamie Goode , 263, Novartis Foundation, 2004, pp41-53Conference Paper, 2004, DOI
  • McManus R, Kelleher D , Celiac disease - the villain unmasked? (Invited commentary)., New England Journal of Medicine , 348, (25), 2003, p2573-2574Journal Article, 2003, DOI
  • Madrigal-Estebas, L., McManus, R., Byrne, B., Lynch, S., Doherty, D.G., Kelleher, D., O'Donoghue, D.P., (...), O'Farrelly, C. , Erratum: Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA transcripts: Implications for extrathymic T-cell differentiation (Human Immunology (1997) 58 (83)) , 2000, - 719Miscellaneous, 2000, DOI
  • Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R,Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML,Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA,Wapenaar MC, Deloukas P, McGinnis R, McManus R*, Wijmenga C*, van Heel DA*., Newly identified genetic risk variants for celiac disease related to the immune response., Nature Genetics, 40, 2008, p395-402Journal Article, 2008, DOI , TARA - Full Text
  • Patel KD, Murphy RT, White M, Gasparrow D, Kelleher DP, Ryan T, McManus R, Ryan AW., Interleukin 17: an unlikely marker of acute coronary syndrome?, Atherosclerosis, 205, (1), 2009, p33 - 34Journal Article, 2009
  • Patel KD, Duggan SP, Currid CA, Gallagher WM, McManus R, Kelleher D, Murphy RT, Ryan AW, High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of interferon gamma and interleukin-10 post myocardial infarction., Clinical immunology (Orlando, Fla.), 133, (2), 2009, p251-6Journal Article, 2009, DOI
  • Phillips CM, Goumidi L, Bertrais S, Field MR, Peloso GM, Shen J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults., The Journal of nutrition, 139, (11), 2009, p2011-7Journal Article, 2009, DOI
  • Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM, Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome., The American journal of clinical nutrition, 90, (6), 2009, p1665-73Journal Article, 2009, DOI
  • Phillips CM, Goumidi L, Bertrais S, Field MR, Ordovas JM, Cupples LA, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Gibney MJ, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults., The Journal of nutrition, 140, (2), 2010, p238-44Journal Article, 2010, DOI
  • Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Mehegan J, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM, Additive Effect of Polymorphisms in the IL-6, LTA, and TNF-{alpha} Genes and Plasma Fatty Acid Level Modulate Risk for the Metabolic Syndrome and Its Components., The Journal of clinical endocrinology and metabolism, 95, 2010, p1386 - 1394Journal Article, 2010, DOI
  • Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C, Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling., Gut, 58, (8), 2009, p1078-83Journal Article, 2009, DOI
  • Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Ádány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek , Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA, Multiple common variants for celiac disease influencing immune gene expression, Nature Genetics, 42, (4), 2010, p295 - 302Journal Article, 2010, DOI , URL , TARA - Full Text
  • White M, Lawless MW, O'Dwyer MJ, Grealy R, O'Connell B, Stordeur P, Kelleher D, McManus R*, Ryan T*, Transforming Growth Factor beta-1 and Interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection, Cytokine, 50, 2010, p322 - 327Journal Article, 2010, DOI
  • Phillips, CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome, Journal of Lipid Research, 51, 2010, p3500 - 3507Journal Article, 2010
  • Brophy K*, Ryan AW*, Turner G, Trimble V, Patel KD, O'Morain C, Kennedy NP, Egan B, Close E, Lawlor G, MacMathuna P, Stevens FM, Abuzakouk M, Feighery C, Kelleher D, McManus R, Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study, BMC Medical Genetics, 11, (76), 2010Journal Article, 2010, URL , TARA - Full Text
  • White M, Martin-Loeches I, Lawless MW, O'Dwyer MJ, Doherty DG, Young V, Kelleher D, McManus R, Ryan T, Hospital acquired pneumonia after lung resection surgery displays characteristic cytokine profiles, Chest, 139, 2011, p626 - 632Journal Article, 2011, DOI
  • Bowes J, Flynn E, Ho P, Aly B, Morgan AW, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, Fitzgerald O, Packham J, Bruce IN, Barton A, Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis, Annals of Rheumatic Diseases, 69, (12), 2010, p2199-2203Journal Article, 2010, DOI , URL , TARA - Full Text
  • Strange A, Capon F, Spencer CC, Knight J, Weale M, Allen M, Barton A, Band G, Bellenguez C, Bergboer J, Blackwell J, Bramon E, Bumpstead S, Casas J, Cork M, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt S, Irvine A, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus H, Mathew C, McLean W, McManus R, Mössner R, Moutsianas L, Naluai Å, Nestle F, Novelli G, Onoufriadis A, Palmer C, Perricone C, Pirinen M, Plomin R, Potter S, Pujol R, Rautanen A, Riveira-Munoz E, Ryan A, Salmhofer W, Samuelsson L, Sawcer S, Schalkwijk J, Smith C, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan A, Warren R, Weger W, Wolk K, Wood N, Worthington J, Young H, Zeeuwen P, Hayday A, Burden A, Griffiths C, Kere J, Reis A, McVean G, Evans D, Brown M, Barker J, Peltonen L, Donnelly P, Trembath R, Identification of novel psoriasis susceptibility loci and genetic interaction between HLA-C and ERAP1 provides evidence for an integrated pathogenic pathway., Nature Genetics, 42, 2010, p985 - 990Journal Article, 2010, DOI
  • Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, Juneblad K, Apel M, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Lascorz J, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Herold C, Steffens M, Klareskog L, Wienker TF, FitzGerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A, Variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis, Nature Genetics, 42, 2010, p996 - 999Journal Article, 2010, DOI
  • Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, ACC2 gene polymorphisms, metabolic syndrome and gene-nutrient interactions with dietary fat, Journal of Lipid Research, 51, (12), 2010, p3500-3507Journal Article, 2010, DOI
  • Catherine M. Phillips, Louisa Goumidi, Sandrine Bertrais, Martyn R. Field, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells and Helen M. Roche, Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk, Atherosclerosis, 214, (2), 2011, p408-414Journal Article, 2011, DOI , URL , TARA - Full Text
  • Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, Brouwer E, Posthumus MD, Remmers EF, Tucci F, Toes R, Grandone E, Mazzilli MC, Rybak A, Cukrowska B, Coenen MJ, Radstake TR, van Riel PL, Li Y, de Bakker PI, Gregersen PK, Worthington J, Siminovitch KA, Klareskog L, Huizinga TW, Wijmenga C, Plenge RM, Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci., PLoS genetics, 7, (2), 2011, pe1002004Journal Article, 2011, DOI , URL , TARA - Full Text
  • Bowes J, Eyre S, Flynn E, Ho P, Salah S, Warren RB, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, Fitzgerald O, Packham J, Morgan AW, Griffiths CE, Bruce IN, Worthington J, Barton A, Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris., Annals of the Rheumatic Diseases, 70, (6), 2011, p1016 - 1019Journal Article, 2011, DOI , URL , TARA - Full Text
  • Phillips CM, L Goumidi, Bertrais S, Field MR, McManus R, S Hercberg, Lairon D, Planells R, Roche HM, Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome, Journal of Nutritional Biochemistry, 23, (3), 2011, p239-244Journal Article, 2011, DOI
  • Catherine M Phillips, Emmanuelle Kesse-Guyot, Namanjeet Ahluwalia, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells, Helen M Roche, Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk, Atherosclerosis, 220, (2), 2012, p513-519Journal Article, 2012, DOI , TARA - Full Text
  • White M, Mahon V, Grealy R, Doherty DG, Stordeur P, Kelleher DP, McManus R, Ryan T, Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators., Critical Care (London, England), 15, (3), 2011, pR158Journal Article, 2011, DOI , URL , TARA - Full Text
  • Hughes DJ, McManus R, Neary P, O'Morain C, O'Sullivan M, Common Variation in the Vitamin D Receptor Gene and Risk of Inflammatory Bowel Disease in an Irish Case-Control Study, European Journal of Gastroenterology & Hepatology , 23, 2011, p807 - 812Journal Article, 2011, DOI
  • Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A, Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis, Annals of Rheumatic Diseases , 70, 2011, p1641 - 1644Journal Article, 2011, DOI , TARA - Full Text
  • Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy G, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK, Myeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock, Immunity, 34, 2011, p715 - 728Journal Article, 2011, DOI , TARA - Full Text
  • Babar M, Ryan AW, Anderson LA, Segurado R, Turner G, Murray LJ, Murphy SJ, Johnston BT, Comber H, Reynolds JV, McManus R, Genes of the Interleukin-18 pathway are associated with susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma, American Journal of Gastroenterology, 107, (9), 2012, p1331-1341Journal Article, 2012, DOI
  • Bowes J, Ho P, Flynn E, Marzo-Ortega H, UKRAG Consortium, Coates L, McManus R, Ryan A, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A, Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort, Annals of Rheumatic Diseases, 71, (8), 2012, p1350-1354Journal Article, 2012, DOI , TARA - Full Text
  • Knight J, Spain SL, Capon F, Hayday A, Nestle FO, Clop A, Wellcome Trust Case Control Consortium, Genetic Analysis of Psoriasis Consortium§, I-chip for Psoriasis Consortium, Barker JN. Weale ME, Trembath RC, Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis, Human Molecular Genetics, 21, (23), 2012, p5185 - 5192Journal Article, 2012, DOI , TARA - Full Text
  • Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC, Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity., Nature genetics, 44, (12), 2012, p1341-1348Journal Article, 2012, DOI
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Research Expertise

  • Title
    How immunology can help to address the COVID-19 epidemic in Ireland
    Summary
    Funding Agency
    Science Foundation Ireland
    Date From
    01 September 2020
    Date To
    31 August 2023
  • Title
    COVREs: Understanding the Host-Virus Response in Patients with Mild versus Serious Disease
    Summary
    The COVID-19 pandemic poses enormous challenges to the health of the Irish population, north and south. Developments in either jurisdiction may affect the other, necessitating disease management on an all-island basis. Susceptibility to SARS-CoV-2 and disease manifestation are affected by both genetic and environmental/demographic factors - the latter including age, gender and metabolic parameters. Host genomics from HLA/MHC alleles to genes with immune function are known to modify host response and clinical course very considerably in many infectious diseases. Thus there is enormous interest internationally in how host genetics affects COVID-19; however there is no data on the host genomics of the Irish population in relation to COVID-19 currently. This is an important and significant deficit which must be rectified to understand the pandemic dynamics in Ireland. The partners in this application, including Genuity Sciences will sequence (at no cost) whole genomes and transcriptomes of 1000 individuals from Ireland. We will also collect information on gene regulatory mechanisms (epigenetics) and the oral-microbiome. Finally we will address knowledge deficits relating to downstream immune function in these patients to generate an all-Ireland repository of genomic, transcriptomic, epigenetic and immune related data which will be an important tool to combat this disease.
    Funding Agency
    Science Foundation Ireland
    Date From
    01 December 2020
    Date To
    31 January 2021
  • Title
    Protecting the ICU - A prognostic test to predict clinical course and direct therapy in patients infected with SARS-COV2
    Summary
    SARS-COV2 infection is threatening acute hospital and intensive care unit capacity globally. There is an acute need for a prognostic test which will identify patients at either high or low risk of developing a severe response to COVID-19 infection. Such a test, by identifying whether the immune response is insufficient or excessive, could also help inform therapeutic options during disease progression, We have a long track-record of investigating immune parameters in hospitalised patients with infection and sepsis. We have previously identified a 6 cytokine signature upon admission that discriminates between patients who will experience an uneventful recovery compared to those who develop sepsis. We have also identified IL-7 as an indicator of severe disease in children with viral bronchiolitis and more recently described characteristic immune deficits in severe patients notably dominated by reduced effector T-lymphocyte differentiation. These findings indicate that defects in the immune response in the early stages of disease are strongly correlated with poor outcome. We propose to investigate patients with mild infection, severe infection and controls using a state-of-the art single cell transcriptomic analysis platform. This will allow us to identify a unique Immune response signature from different cells in patients that have mild vs those with a severe response to infection. This signature will be rapidly transformed into a simple flow cytometry or PCR based prognostic assay that can be run in hospital laboratories. This simple assay will identify individuals likely to develop a severe reaction to SARS-COV2 infection requiring ICU admission, but more importantly, will identify infected individuals that can be safely sent home to self- isolate freeing up critical hospital resources, decreasing costs and reducing the risk of viral spread. Importantly, it will also identify immune deficits in patients, informing evidence-based therapeutic options. This project can deliver a prognostic assay within 6 months.
    Funding Agency
    HRB
    Date From
    May 2020
    Date To
    Apr 2021
  • Title
    Changing Landscapes in the Health and Life Sciences: Ethical Challenges of Big Data
    Summary
    Funding Agency
    EU
    Date From
    Sept 2020
    Date To
    Aug 2023

Recognition

  • Wellcome Trust / Health Research Board 'New Blood' Fellowship 1998
  • Fellow, Trinity College Dublin 2009
  • Science Foundation Ireland Principal Investigator 2010
  • American Society of Human Genetics present
  • European Society of Human Genetics present
  • Irish Society of Human Genetics present
  • Irish Society of Immunology present
  • Member, Scientific Committee, FINBAR, all-Ireland genetic epidemiology study of oesophageal cancer 2003 - 2009
  • Member of Molecular Medicine Ireland (MMI)/Clinical Research Development Ireland (CRDI) Education Committee 2003 - 2020
  • Chairperson of Eurolife Joint Educational Programme in Translational and Experimental Medicine 2008 - 2013
  • Member of Eurolife Network of European Universities in the Life Sciences Steering Committee 2005 - 2015
  • Council member, Irish Society of Human Genetics 2004 - 2008
  • Member of LIPGENE WP1.1. Genetic association study of candidate genes in the Metabolic Syndrome in a large French cohort. 2004 - 2009
  • Coordinator, Eurolife Network 2009 - 2011
  • Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics