Medicine

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Level 1
Trinity Biomedical Sciences Institute
Trinity College
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Professor Padraic Fallon

Professor Padraic Fallon

Professor of Translational Immunology

Interim IMM Director

Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is Professor of Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema), inflammatory bowel disease (ulcerative colitis and Crohn's disease).,as well as haemophilia .

Since 2007, Prof Fallon has generated over €13 million of funding as Principal Investigator supporting research programmes on inflammatory diseases, clinical immunology and infections (helminths and COVID-19). The main diseases addressed are fibrotic disorders, allergic lung and skin inflammation, inflammatory bowel disease and haemophilia. The research on inflammatory diseases is across the human lifespan; from studies on skin diseases in infants, asthma in adults to the metabolic syndrome in the elderly.

Prof Fallon has delivered a number of seminal discoveries across the field of immunology. He is an author of ~220 papers peer-reviwed publications in the leading scientifc journals. Fallon and Luke O"Neill, also Trinity College, are the only scientists in Ireland that have been ranked in top 1% of scientists in the world by citations for publications from 2018-2022 in immunology (Clarivate Analytics).

Publications and Further Research Outputs

  • Cluxton, C.D., Caffrey, B.E., Kinsella, G.K., (...), Fares, M.A., Fallon, P.G., Functional conservation of an ancestral Pellino protein in helminth species, Scientific Reports, 5, 2015, p11687-Journal Article, 2015, DOI , TARA - Full Text
  • Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., Journal of Allergy and Clinical Immunology, 137, (2), 2015, 482-491Journal Article, 2015, DOI , TARA - Full Text
  • Walker JA, Oliphant CJ, Englezakis A, Yu Y, Clare S, Rodewald HR, Belz G, Liu P, Fallon PG, McKenzie AN, Bcl11b is essential for group 2 innate lymphoid cell development, The Journal of Experimental Medicine, 212 , (6), 2015, -Journal Article, 2015, DOI , TARA - Full Text
  • Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne KJ., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer, Molecular Cancer, ( ), 2015, p0.1186/s12943-015-0310-8Journal Article, 2015, DOI , TARA - Full Text
  • Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG., Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells., European Journal of Immunology, 2015Journal Article, 2015, DOI , TARA - Full Text
  • MacLeod AK, Fallon PG, Sharp S, Henderson CJ, Wolf CR, Huang JT., An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes., Molecular & Cellular Proteomics, 2015Journal Article, 2015, DOI , TARA - Full Text
  • Fernandes P, O'Donnell C, Lyons C, Keane J, Regan T, O'Brien S, Fallon P, Brint E, Houston A, Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation., The Journal of Immunology, 2014Journal Article, 2014, DOI
  • Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., The Journal of allergy and clinical immunology, 2015Journal Article, 2015, DOI , TARA - Full Text
  • Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT., IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation., Mucosal Immunology, (Jan 27), 2016, p1193-1204Journal Article, 2016, DOI
  • Patrick T. Walsh, Padraic G. Fallon, The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases, Ann N Y Acad Sci, 2016Journal Article, 2016, DOI
  • Schwartz, C., O'Grady, K., Lavelle, E.C., Fallon, P.G., Interleukin 33: An innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer, European Journal of Immunology, 46, (5), 2016, p1091-1100Journal Article, 2016, DOI
  • Kennedy, E.A., Connolly, J., Hourihane, J.O., Fallon, P.G., McLean, W.H.I., Murray, D., Jo, J.-H., Segre, J.A., Kong, H.H., Irvine, A.D., Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year, Journal of Allergy and Clinical Immunology, 139, (1), 2017, p166-172Journal Article, 2017, DOI , TARA - Full Text
  • O'Sullivan J., O'Sullivan J., Aguila S., Aguila S., McRae E., Ward S., Ward S., Rawley O., Fallon P., Brophy T., Brophy T., Preston R., Preston R., Brady L., Sheils O., Chion A., Chion A., O'Donnell J., O'Donnell J., O'Donnell J., N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor, Journal of Thrombosis and Haemostasis, 14, (12), 2016, p2446-2457Journal Article, 2016, DOI
  • Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS., N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance., Blood, 128, (15), 2016, p1959-1968Journal Article, 2016, DOI
  • Fleury, O.M., McAleer, M.A., Feuillie, C., Formosa-Dague, C., Sansevere, E., Bennett, D.E., Towell, A.M., McLean, W.H.I., Kezic, S., Robinson, D.A., Fallon, P.G., Foster, T.J., Dufrêne, Y.F., Irvine, A.D., Geoghegan, J.A., Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis, Infection and Immunity, 85, (6), 2017, ppii: e00994-16Journal Article, 2017, TARA - Full Text
  • Ward, Soracha E and O'Sullivan, Jamie M and Drakeford, Clive and Aguila, Sonia and Jondle, Christopher N and Sharma, Jyotika and Fallon, Padraic G and Brophy, Teresa M and Preston, Roger J S and Smyth, Paul and Sheils, Orla and Chion, Alain and O'Donnell, James S, A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance, Blood, 2017Journal Article, 2017, DOI , URL
  • Fallon, P.G. and Lavin, M. and O'Donnell, J.S., SIPPET: insights into factor VIII immunogenicity, Journal of Thrombosis and Haemostasis, 16, (1), 2018, p36-38Journal Article, 2018, DOI , URL
  • Oleszycka, E., McCluskey, S., Sharp, F.A., Muñoz-Wolf, N., Hams, E., Gorman, A.L., Fallon, P.G. and Lavelle EC., The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses., European Journal of Immunology, 2018, 705-715Journal Article, 2018, DOI
  • Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG., The helminth T2 RNase "1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30, (2), 2016, p824-835Journal Article, 2016, DOI
  • Halim TY, Hwang YY, Scanlon ST, Zaghouani H, Garbi N, Fallon PG, McKenzie AN., Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses., Nature immunology, 17, (1), 2016, p57-64Journal Article, 2016, DOI
  • Jarrett R, Salio M, Lloyd-Lavery A, Subramaniam S, Bourgeois E, Archer C, Cheung KL, Hardman C, Chandler D, Salimi M, Gutowska-Owsiak D, de la Serna JB, Fallon PG, Jolin H, Mckenzie A, Dziembowski A, Podobas EI, Bal W, Johnson D, Moody DB, Cerundolo V, Ogg G., Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase., Science translational medicine, 8, (325), 2016, p325ra18Journal Article, 2016, DOI
  • Floudas A, Amu S, Fallon PG., New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression., Journal of clinical immunology, 36 Suppl 1, 2016, p25-33Journal Article, 2016, DOI
  • Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ., Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation., Science translational medicine, 7, (303), 2015, p303ra140Journal Article, 2015, DOI
  • Hams E, Bermingham R, Fallon PG., Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis., Frontiers in immunology, 6, 2015, p597Journal Article, 2015, DOI , TARA - Full Text
  • Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, Yang X, Nakamura M, Wang J, Zhuang R, Morikawa H, Xue Y, Braun H, Beyaert R, Samani N, Nakae S, Hams E, Dissing S, Fallon PG, Langer R, Cao Y., The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages., Nature communications, 7, 2016, p11385Journal Article, 2016, DOI , TARA - Full Text
  • Korniotis S, Gras C, Letscher H, Montandon R, Mégret J, Siegert S, Ezine S, Fallon PG, Luther SA, Fillatreau S, Zavala F., Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells., Nature communications, 7, 2016, p12134Journal Article, 2016, DOI
  • Taylor CT, Doherty G, Fallon PG, Cummins EP., Hypoxia-dependent regulation of inflammatory pathways in immune cells., The Journal of clinical investigation, 126, (10), 2016, p3716-3724Journal Article, 2016, DOI
  • de Kleer IM, Kool M, de Bruijn MJ, Willart M, van Moorleghem J, Schuijs MJ, Plantinga M, Beyaert R, Hams E, Fallon PG, Hammad H, Hendriks RW, Lambrecht BN., Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung., Immunity, 45, (6), 2016, p1285-1298Journal Article, 2016, DOI , TARA - Full Text
  • Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nair U, Ghneim K, Fallon PG, Sekaly RP, Barouch DH, Shalek AK, Bruckbauer A, Strid J, Batista FD., Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells., Cell, 172, (3), 2018, p517-533.e20Journal Article, 2018, DOI , TARA - Full Text
  • Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG., IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation., Journal of immunology (Baltimore, Md. : 1950), 199, (2), 2017, p707-717Journal Article, 2017, DOI
  • Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie ANJ, Fallon PG., ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control., The Journal of experimental medicine, 214, (9), 2017, p2507-2521Journal Article, 2017, DOI
  • Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM., Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion., Immunity, 47, (4), 2017, p710-722.e6Journal Article, 2017, DOI , TARA - Full Text
  • Floudas A, Cluxton CD, Fahel J, Khan AR, Saunders SP, Amu S, Alcami A, Fallon PG., Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A., PLoS neglected tropical diseases, 11, (10), 2017, pe0006012Journal Article, 2017, DOI , TARA - Full Text
  • Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC., Title: Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis., QJM : monthly journal of the Association of Physicians, 2017Journal Article, 2017, DOI
  • Schwartz, C., Hams, E., Fallon, P.G. , Helminth Modulation of Lung Inflammation, Trends in Parasitology, 2018Journal Article, 2018, DOI , TARA - Full Text
  • Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC., Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis., QJM, 2018, p217-224Journal Article, 2018, URL , TARA - Full Text
  • Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117Journal Article, 2018, DOI , URL
  • Neill, D.R. and Fallon, P.G., Innate lymphoid cells and parasites: Ancient foes with shared history, Parasite Immunology, 40, (2), 2018Journal Article, 2018, DOI , URL , TARA - Full Text
  • Vandeghinste, N. and Klattig, J. and Jagerschmidt, C. and Lavazais, S. and Marsais, F. and Haas, J.D. and Auberval, M. and Lauffer, F. and Moran, T. and Ongenaert, M. and Van Balen, M. and Dupont, S. and Lepescheux, L. and Garcia, T. and HÃ"rtle, S. and Eyerich, K. and Fallon, P.G. and Brys, R. and Steidl, S., Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis, Journal of Investigative Dermatology, 2018, p1555-1563Journal Article, 2018, DOI , URL
  • Halim, T.Y.F. and Rana, B.M.J. and Walker, J.A. and Kerscher, B. and Knolle, M.D. and Jolin, H.E. and Serrao, E.M. and Haim-Vilmovsky, L. and Teichmann, S.A. and Rodewald, H.-R. and Botto, M. and Vyse, T.J. and Fallon, P.G. and Li, Z. and Withers, D.R. and McKenzie, A.N.J., Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells, Immunity, 2018Journal Article, 2018, DOI , URL , TARA - Full Text
  • Sambit K. Nanda, Tsunehisa Nagamori, Mark Windheim, Sylvia Amu, Gabriella Aviello, Janet Patterson-Kane, J. Simon C. Arthur, Steven C. Ley, Padraic Fallon, Philip Cohen, ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism, The Journal of Immunology, 201, (11), 2018, p3373--3382Journal Article, 2018
  • Khan, A.R., Amu, S., Saunders, S.P., Hams, E., Blackshields, G., Leonard, M.O., Weaver, C.T., Sparwasser, T., Sheils, O., Fallon, P.G., Ligation of TLR7 on CD19<sup>+</sup>CD1d<sup>hi</sup> B cells suppresses allergic lung inflammation via regulatory T cells, European Journal of Immunology, 45, (6), 2015, p1842-1854Journal Article, 2015
  • Ward, J.B.J., Lawler, K., Amu, S., Taylor, C.T., Fallon, P.G., Keely, S.J., Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea, FASEB Journal, 25, (2), 2011, p535-543Journal Article, 2011
  • Zaiss, M.M., Kurowska-Stolarska, M., Böhm, C., Gary, R., Scholtysek, C., Stolarski, B., Reilly, J., Kerr, S., Millar, N.L., Kamradt, T., McInnes, I.B., Fallon, P.G., David, J.-P., Liew, F.Y., Schett, G., IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-"-mediated bone loss, Journal of Immunology, 186, (11), 2011, p6097-6105Journal Article, 2011
  • Wong, S.H., Barlow, J.L., Nabarro, S., Fallon, P.G., McKenzie, A.N.J., Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response, Immunology, 131, (1), 2010, p77-88Journal Article, 2010
  • Saunders, S.P., Barlow, J.L., Walsh, C.M., Bellsoi, A., Smith, P., McKenzie, A.N.J., Fallon, P.G., C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide (Journal of Immunology (2010) 184, (2627-2637)), Journal of Immunology, 184, (5), 2010Journal Article, 2010
  • Cummins, E.P., Seeballuck, F., Keely, S.J., Mangan, N.E., Callanan, J.J., Fallon, P.G., Taylor, C.T., The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis, Gastroenterology, 134, (1), 2008Journal Article, 2008
  • Fallon, P.G., Emson, C.L., Smith, P., McKenzie, A.N.J., IL-13 overexpression predisposes to anaphylaxis following antigen sensitization, Journal of Immunology, 166, (4), 2001, p2712-2716Journal Article, 2001
  • Townsend, M.J., Fallon, P.G., Matthews, D.J., Jolin, H.E., McKenzie, A.N.J., T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses, Journal of Experimental Medicine, 191, (6), 2000, p1069-1075Journal Article, 2000
  • Fallon, P.G., Smith, P., Dunne, D.W., Type 1 and type 2 cytokine-producing mouse CD4+and CD8+T cells in acute Schistosoma mansoni infection, European Journal of Immunology, 28, (4), 1998, p1406-1414Journal Article, 1998
  • Webster, M., Fallon, P.G., Fulford, A.J.C., Butterworth, A.E., Ouma, J.H., Kimani, G., Dunne, D.W., Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: Elevated IgE to adult worm, Parasite Immunology, 19, (7), 1997, p333-335Journal Article, 1997
  • Fallon, P.G., Sturrock, R.F., Capron, A., Niang, M., Doenhoff, M.J., Short report: Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni, American Journal of Tropical Medicine and Hygiene, 53, (1), 1995, p61-62Journal Article, 1995
  • Schwartz C, Fallon PG., Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion., Frontiers Immunology, 9, 2018, p2492-Journal Article, 2018, DOI , TARA - Full Text
  • Knolle MD, Chin SB, Rana BMJ, Englezakis A, Nakagawa R, Fallon PG, Git A, McKenzie ANJ., MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity., Frontiers Immunology, 9, 2018, p2232-Journal Article, 2018, DOI , TARA - Full Text
  • de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ., Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)., Eur J Med Chem, 162, 2019, p80 - 108Journal Article, 2019, DOI
  • Senra L, Mylonas A, Kavanagh R.D, Fallon P.G, Conrad C, Borowczyk-Michalowska J, Wrobel L.J, Kaya G, Yawalkar N, Boehncke W.-H, Brembilla N.C, IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation, Journal of Investigative Dermatology, 2019Journal Article, 2019, DOI , URL
  • Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O†Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β, Allergy: European Journal of Allergy and Clinical Immunology, 2019, p1--Journal Article, 2019, DOI , URL , TARA - Full Text
  • Nanda S.K, Nagamori T, Windheim M, Amu S, Aviello G, Patterson-Kane J, Simon C. Arthur J, Ley S.C, Fallon P, Prof P.C, Abin2 function is required to suppress DSS-induced colitis by a TPL2-independent mechanism, Journal of Immunology, 201, (11), 2018, p3373 - 3382Journal Article, 2018, DOI , URL
  • Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÃ"rtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6Journal Article, 2019, TARA - Full Text
  • Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT., Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction., Nature communications, 10, (1), 2019, p4003Journal Article, 2019, DOI , TARA - Full Text
  • Browning J, Rooney M, Hams E, Takahashi S, Mizuno S, Sugiyama F, Fallon PG, Kelly VP., Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression., Molecular biology reports, 2020Journal Article, 2020, DOI
  • Alí Alejo, Carolina Sánchez, Sylvie Amu, Padraic G. Fallon and Antonio Alcamí, Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor, Journal of Clinical Medicine, 9, (1), 2020, p1-25Journal Article, 2020, DOI , TARA - Full Text
  • Sean P. Saunders, Achilleas Floudas, Tara Moran, Ciara M. Byrne, Michael D. Rooney, Caoimhe M.R. Fahy, Joan A. Geoghegan, Yoichiro Iwakura, Padraic G. Fallon, Christian Schwartz, Dysregulated skin barrier function in Tmem79 mutant mice promotes IL"17A"dependent spontaneous skin and lung inflammation., Allergy, 2020Journal Article, 2020
  • Liam Townsend, Adam H Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig Bourke, Niall Conlon, Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health, Frontiers In Immunology, 2021Journal Article, 2021
  • Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT., SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin, Journal of Immunology, 207, (2), 2021, p651 - 660Journal Article, 2021, DOI
  • Floudas, Achilleas, Aviello, Gabriella, Schwartz, Christian, Jeffery, Ian B., O'Toole, Paul W., Fallon, Padraic G., Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis, Infection and Immunity, 87, (8), 2019Journal Article, 2019, DOI
  • Bidault G., Virtue S., Petkevicius K., Jolin H.E., Dugourd A., Guenantin A.-C., Leggat J., Mahler-Araujo B., Lam B.Y.H., Ma M.K., Dale M., Carobbio S., Kaser A., Fallon P.G., Saez-Rodriguez J., McKenzie A.N.J., Vidal-Puig A., SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation, Nature Metabolism, 3, (9), 2021, p1150 - 1162, p1150-1162Journal Article, 2021, DOI
  • Lok L.S.C., Walker J.A., Jolin H.E., Scanlon S.T., Ishii M., Fallon P.G., McKenzie A.N.J., Clatworthy M.R., Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses, Frontiers in Immunology, 12, 2021Journal Article, 2021, DOI
  • Muhandes L., Chapsa M., Pippel M., Behrendt R., Ge Y., Dahl A., Yi B., Dalpke A., Winkler S., Hiller M., Boutin S., Beissert S., Jessberger R., Fallon P.G., Roers A., Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice, Journal of Investigative Dermatology, 141, (11), 2021, p2611 - 2619.e2, p2611-2619.e2Journal Article, 2021, DOI
  • Hams E., Roberts J., Bermingham R., Fallon P.G., Functions for Retinoic Acid-Related Orphan Receptor Alpha (ROR") in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock, Frontiers in Immunology, 12, 2021Journal Article, 2021, DOI
  • Thyssen J.P., Jakasa I., Riethmuller C., Schon M.P., Braun A., Haftek M., Fallon P.G., Wroblewski J., Jakubowski H., Eckhart L., Declercq W., Koppes S., Engebretsen K.A., Bonefeld C., Irvine A.D., Keita-Alassane S., Simon M., Kawasaki H., Kubo A., Amagai M., Matsui T., Kezic S., Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice, Journal of Investigative Dermatology, 140, (3), 2020, p615 - 623.e5, p615-623.e5Journal Article, 2020, DOI
  • Fallon P.G., Schwartz C., The high and lows of type 2 asthma and mouse models, Journal of Allergy and Clinical Immunology, 145, (2), 2020, p496 - 498, p496-498Journal Article, 2020, DOI
  • Lu Y., Basatemur G., Scott I.C., Chiarugi D., Clement M., Harrison J., Jugdaohsingh R., Yu X., Newland S.A., Jolin H.E., Li X., Chen X., Szymanska M., Haraldsen G., Palmer G., Fallon P.G., Cohen E.S., McKenzie A.N.J., Mallat Z., Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages, Immunity, 52, (5), 2020, p782 - 793.e5, p782-793.e5Journal Article, 2020, DOI
  • Schwartz C., Fallon P.G., Determining Coreceptor Expression and Function in Murine ILC2 Through Flow Cytometry Characterization and Coculture Techniques, Methods in Molecular Biology, 2121, 2020, p71 - 82, p71-82Journal Article, 2020, DOI
  • McElroy AN, Invernizzi R, Laskowska JW, O'Neill A, Doroudian M, Moghoofei M, Mostafaei S, Li F, Przybylski AA, O'Dwyer DN, Bowie AG, Fallon PG, Maher TM, Hogaboam CM, Molyneaux PL, Hirani N, Armstrong ME, Donnelly SC., Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis., American journal of respiratory and critical care medicine, 2022Journal Article, 2022, DOI
  • Schwartz C, Schmidt V, Deinzer A, Hawerkamp HC, Hams E, Bayerlein J, Röger O, Bailer M, Krautz C, El Gendy A, Elshafei M, Heneghan HM, Hogan AE, O'Shea D, Fallon PG., Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity., Science translational medicine, 14, (635), 2022, peabj6879Journal Article, 2022, DOI
  • Leon, G. Hernandez-Santana, Y.E., Irwin, N., Giannoudaki, E., O'Neill, S., Czismadia, I., Gogarty, M., Lee, T.J., Ruane, D., Long, A., Fallon, P.G., Hussey, S. Walsh, P.T. , IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells., Mucosal Immunology, 2022Journal Article, 2022, TARA - Full Text
  • Matarazzo, L. and Hernandez Santana, Y.E. and Walsh, P.T. and Fallon, P.G., The IL-1 cytokine family as custodians of barrier immunity, Cytokine, 154, (155890), 2022Journal Article, 2022, DOI
  • Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Cian Mangan, Fergal Howley, Siobhan O'Regan, Noor Adeebah Mohamed Razif, Ciara Conlan, Ruth Argue, Samuel Holohan, Adam Dyer, Fara Salleh, Liam Townsend, Gerard Hughes, Colm Kerr, Derval Reidy, Alberto Sanz, Emma Connolly, Andrea Kelly, Emma Leacy, Conor Reddy, Siobhan Gargan, Eamon Breen, Heike Hawerkamp, Jean Dunne, Ignacio Martin-Loeches, Anne Marie McLaughlin, Aideen Long, Orla Shiels, Padraic Fallon, Martina Hennessy, Roman Romero-Ortuno, Ciaran Bannan, Anna Rose Prior, Ana Rakovac, William McCormack, Ross McManus, Seamus Donnelly, Colm Bergin, Mark Little, Clíona Ní Cheallaigh, Niall Conlon, Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19, HRB Open Research, 2022Journal Article, 2022, DOI
  • Runtsch, M.C. and Angiari, S. and Hooftman, A. and Wadhwa, R. and Zhang, Y. and Zheng, Y. and Spina, J.S. and Ruzek, M.C. and Argiriadi, M.A. and McGettrick, A.F. and Mendez, R.S. and Zotta, A. and Peace, C.G. and Walsh, A. and Chirillo, R. and Hams, E. and Fallon, P.G. and Jayamaran, R. and Dua, K. and Brown, A.C. and Kim, R.Y. and Horvat, J.C. and Hansbro, P.M. and Wang, C. and O'Neill, L.A.J., Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages, Cell Metabolism, 34, (3), 2022, p487-501.e8Journal Article, 2022, DOI , URL
  • Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Deirdre O'Connor, Román Romero Ortuño, Rose Anne Kenny, An examination of the prevalence of metabolic syndrome in older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing (TILDA), PLOS ONE, 2022Journal Article, 2022, DOI
  • Kevin McCarthy, Eamon Laird, Aisling M. O"Halloran, Cathal Walsh, Martin Healy, Annette L. Fitzpatrick, James B. Walsh, Belinda Hernandez, Padraic Fallon, Anne Molloy, Rose Anne Kenny, Association between vitamin D deficiency and the risk of prevalent type 2 diabetes and incident prediabetes: A prospective cohort study using data from The Irish Longitudinal Study on Ageing (TILDA), eClinical Medicine, 53, 2022, p101654Journal Article, 2022
  • Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Román Romero Ortuño, Rose Anne Kenny, Association between metabolic syndrome and risk of both prevalent and incident frailty in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA), Experimental Gerontology, 2022Journal Article, 2022, DOI
  • Flynn L, Barr MP, Baird AM, Smyth P, Casey OM, Blackshields G, Greene J, Pennington SR, Hams E, Fallon PG, O'Leary J, Sheils O, Finn SP., Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness, SCIENTIFIC REPORTS, 10, 2020, p1132-Journal Article, 2020
  • Hernández-Santana, YE, Leon, G, St Leger,D, Fallon, PG, Walsh, PT, Expression of the Interleukin-36 receptor on keratinocytes is required to orchestrate psoriasiform inflammation in mice., Life Science Alliance, 3, 2020, p201900586-Journal Article, 2020
  • Panova V, Gogoi M, Rodriguez-Rodriguez N, Sivasubramaniam M, Jolin HE, Heycock MWD, Walker JA, Rana BMJ, Drynan LF, Hodskinson M, Pannell R, King G, Wing M, Easton AJ, Oedekoven CA, Kent DG, Fallon PG, Barlow JL, McKenzie ANJ. , Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11, Mucosal Immunology, 14, 2021, p26 - 37Journal Article, 2021
  • Bone R, Fennell BJ, Tam A, Sheldon R, Nocka K, Varghese S, Chang CS, Hawerkamp HC, Yeow A, Saunders SP, Hams E, Walsh PT, Cunningham O, Fallon PG, Discovery and multi-parametric optimization of a high-affinity antibody against Interleukin-25 with neutralizing activity in a mouse model of skin inflammation. , Antibody Therapeutics, 29, 2022, p258 - 267Journal Article, 2022
  • Maquet C, Baiwir J, Loos P, Rodriguez-Rodriguez L, Javaux J, Sandor R, Perin F, Fallon PG, Mack M, Cataldo D, Gillet L, Machiels B., Ly6Chi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology, Science Immunology, 7, 2022, p3240-Journal Article, 2022
  • Schmidt V, Hogan AE, Fallon PG, Schwartz C., Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back., Frontiers in Immunology , 13, 2022, p932893-Journal Article, 2022
  • Hawerkamp HC, Fahy CMR, Fallon PG, Schwartz C, Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis, Skin Health Diseases, (16), 2022, p99-Journal Article, 2022
  • Hawerkamp HC, Fallon PG., Expelliarmus helminthus! Harry Helminth and the Goblet of Alarmins. , Immunity, 2022, p575-Journal Article, 2022
  • Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciumè G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M., When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer., Science Advances, 8, 2022, p3286-Journal Article, 2022
  • Drakeford C, Aguila S, Roche F, Hokamp K, Fazavana J, Cervantes MP, Curtis AM, Hawerkamp HC, Dhami SPS, Charles-Messance H, Hackett EE, Chion A, Ward S, Ahmad A, Schoen I, Breen E, Keane J, Murphy R, Preston RJS, O'Sullivan JM, Sheedy FJ, Fallon P, O'Donnell JS., Von Willebrand factor links primary hemostasis to innate immunity., Nature Communications, 13, 2022, p6320-Journal Article, 2022, DOI
  • Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G. Fallon, Roger J.S. Preston, John Gormley, Kevin Ryan, Niamh M. O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P. Crowley, Susan I. O'Shea, Birgit M. Reipert, Jill M. Johnsen, Steven W. Pipe, Jorge Di Paola, Peter L. Turecek, James S. O'Donnell, Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor, Journal of Thrombosis and Haemostasis, 2023Journal Article, 2023, DOI
  • Carroll, A.M., Haines, L.R., Pearson, T.W., Fallon, P.G., Walsh, C.M., Brennan, C., Breen, E. & Porter, R.K., Identification of a functioning mitochondrial uncoupling protein 1 in thymus, Journal of Biological Chemistry, 280, 2005, p155534 - 155543Journal Article, 2005, DOI , TARA - Full Text
  • Hewett, D.R., Simons, A.L., Mangan, N.E., Jolin, H.E., Green, S.M., Fallon, P.G. & McKenzie, A.N.J., Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome, Human Molecular Genetics, 14, (2), 2005, p335 - 346Journal Article, 2005, DOI , TARA - Full Text
  • Mangan, N.E., Fallon, R.E., Smith, P., Rooijen, N. McKenzie, A.N.J. & Fallon, P.G., Helminth infection protects mice from anaphylaxis via IL-10 producing B cells, Journal of Immunology, 173, 2004, p6346 - 6356Journal Article, 2004, TARA - Full Text
  • Lanoue, A., Clatworthy, M.R., Smith, P. Green, S., Townsend, M.J., Jolin, H.E., Smith, K.G.S., Fallon, P.G. & McKenzie, A.N.J., SIGN-R1 contributes to protection against lethal pneumococcal infection in mice, Journal of Experimental Medicine, 200, (11), 2004, p1383 - 1393Journal Article, 2004, DOI , TARA - Full Text
  • Bogers, J. P., Chatterjee, S., Jacobs, W., Fallon, P.G., Dunne, D.W., Langermans, J.A.M., Deelder, A., Thomas, A.W. & van Marck. E., Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni, Virchows Archiv, 445, 2004, p285 - 291Journal Article, 2004
  • Smith, P., Walsh, C.M, Mangan, N.E., Fallon, R.E., Sayers, J.R., McKenzie, A.N. & Fallon, P.G., Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages, Journal of Immunology, 173, (2), 2004, p1240 - 1248Journal Article, 2004, TARA - Full Text
  • Lauder, A.J., Jolin, H.E., Smith, P., van den Berg, J.G., Jones, A., Wisden, W., Smith. K., Dasvarma, A., Fallon, P.G. & McKenzie, A.N.J., Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines, Journal of Immunology, 173, 2004, p113 - 122Journal Article, 2004, TARA - Full Text
  • Achatz-Straussberger, G., Geisberger, R., Oberndorfer, I., Infuhr, D., Luger, E., Fallon, P., Lamers, M. & Achatz, G., Construction of a sIgE:FLAG-mIgE:GFP reporter mouse strain, International Archives of Allergy and Immunology, 130, (4), 2003, p280 - 287Journal Article, 2003, DOI
  • Jarnicki, A.G. & Fallon, P.G., T helper type-2 cytokine responses: potential therapeutic targets, Current Opinion in Pharmacology, 3, (4), 2003, p449 - 455Journal Article, 2003, DOI
  • McKenzie, A.N.J. and Fallon, P.G., Decoy receptors in the regulation of T Helper cell type 2 response, Journal of Experimental Medicine, 197, (6), 2003, p675 - 679Journal Article, 2003, DOI , TARA - Full Text
  • Fallon, P.G., Gibbons, J., Vervenne, R.A., Richardson, E.J., Fulford, A.J., Sturrock, R.F., Coulson, P.S. Deelder, A.M., Langermans, J.A.M., Thomas, A.W. & Dunne, D.W., Juvenile Rhesus monkeys have lower type 2 cytokine responses than adults following primary infection with Schistosoma mansoni, Journal of Infectious Diseases, 187, 2003, p939 - 945Journal Article, 2003, DOI
  • Brint, E.K., Fitzgerald, K.A., Smith, P., Coyle, A.J., Gutierrez-Ramos, J-C., Fallon, P.G. & O'Neill, L.A.J., Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction, Journal of Biological Chemistry, 277, (51), 2002, p49205 - 49211Journal Article, 2002, DOI , TARA - Full Text
  • Saraiva, M., Smith, P., Fallon, P.G. and Alcami, A., Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus, Journal of Experimental Medicine, 196, (6), 2002, p829 - 839Journal Article, 2002, DOI
  • Cunningham, A.F., Fallon, P.G., Khan, M., Vacheron, S., Acha-Orbea, H., MacLennan, I.C.M., McKenzie, A. & Toellmer, K-M., Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13 and B cells, Journal of Immunology, 169, 2002, p2900 - 2906Journal Article, 2002, URL
  • Fallon, P.G., Jolin, H.E., Smith, P., Emson, C.L., Townsend, M.J., Fallon, R., Smith, P. & McKenzie, A.N.J., IL-4 induces characteristic Th2 response even in the combined absence of IL-5, IL-9 and IL-13, Immunity, 17, (1), 2002, p7 - 17Journal Article, 2002, DOI , TARA - Full Text
  • Buendia, A.J., Fallon, P.G., Del Rio, L., Ortega, N., Caro, M.R., Gallego, M.C. & Salinas, J., Previous infection with the nematode Nippostrongylus brasiliensis alters the immune specific response against Chlamydophila abortus infection, Microbial Pathogenesis, 33, (1), 2002, p7 - 15Journal Article, 2002, DOI
  • Fallon, P.G., Cooper, R.O., Probert, A.J. & Doenhoff, M.J., Immune-dependent chemotherapy of schistosomiasis, Parasitology, 105, 1992, pS41 - S48Journal Article, 1992, DOI
  • Badawi, A.F., Cooper, D.P., Mostafa, M.H., Doenhoff, M.J., Probert, A., Fallon, P.G., Cooper, R, & O'Connor, P.J., Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni, Carcinogenesis, 14, (4), 1993, p653 - 657Journal Article, 1993, URL
  • Fallon, P.G. & Doenhoff, M.J., Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific, American Journal of Tropical Medicine and Hygiene, 51, (1), 1994, p83 - 88Journal Article, 1994, URL
  • Fallon, P.G., McNeice, C., Probert, A.J. & Doenhoff, M.J., Quantification of praziquantel-induced damage on the surface of adult Schistosoma mansoni worms: estimation of esterase and alkaline phosphatase activity, Parasitology Research, 80, (7), 1994, p623 - 625Journal Article, 1994, DOI
  • Fallon, P.G., Smith, P., Nichols, T., Modha, J. & Doenhoff, M.J., Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase: drug-antibody synergy which acts preferentially against female worms, Parasite Immunology, 16, (10), 1994, p529 - 535Journal Article, 1994, DOI
  • Fallon, P.G. & Doenhoff, M.J., Active immunization of mice with Schistosoma mansoni worm membrane antigens enhances efficacy of praziquantel, Parasite Immunology, 17, (5), 1995, p261 - 268Journal Article, 1995, DOI
  • Fallon, P.G., Hamilton, J.V. & Doenhoff, M.J., Efficacy of treatment of murine Schistosoma mansoni infections with praziquantel and oxamniquine correlates with infection intensity: role of host antibody, Parasitology, 111, (1), 1995, p59 - 66Journal Article, 1995, DOI
  • Fallon, P.G., Sturrock, R.F., Capron, A., Niang, M. & Doenhoff, M.J., Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni, American Journal of Tropical Medicine and Hygiene, 53, (1), 1995, p61 - 62Journal Article, 1995, URL
  • Sayers, J.R., Price, H.P., Fallon, P.G. & Doenhoff, M.J., AGA/AGG codon usage in parasites: implications for gene expression in Escherichia coli, Parasitology Today, 11, (9), 1995, p345 - 346Journal Article, 1995, DOI
  • Fallon, P.G., Fookes, R.E. & Wharton, G., Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: implications for drug-antibody synergy, Parasitology, 112, 1996, p47 - 58Journal Article, 1996, DOI
  • Redman, C.A., Robertson, A., Fallon, P.G., Modha, J., Kusel, J.R., Doenhoff, M.J. & Martin, R.J., Praziquantel, an urgent and exciting challenge, Parasitology Today, 12, (1), 1996, p14 - 20Journal Article, 1996, DOI
  • Fallon, P.G., Fookes, R.E. & Doenhoff, M.J., Protection of mice against Schistosoma mansoni infection by passive transfer of sera from infected rabbits, Parasite Immunology, 18, (1), 1996, p7 - 14Journal Article, 1996, DOI
  • Millership, J., Chappell, L.H. & Fallon, P.G., Synergistic action of Cyclosporin A and polyspecific rabbit anti-sera against murine Schistosoma mansoni, Parasite Immunology, 18, (2), 1996, p71 - 77Journal Article, 1996, DOI
  • Sayers, J.R., Price, H.P., Fallon, P.G. & Doenhoff, M.J., AGA/AGG codon usage in parasites: reply, Parasitology Today, 12, 1996, p124 - 125Journal Article, 1996
  • Curtis, R.H.C., Fallon, P.G. & Doenhoff, M.J., Sm480: a high molecular weight Schistosoma mansoni antigen associated with protection, Parasite Immunology, 18, 1996, p149 - 157Journal Article, 1996, DOI
  • Fallon, P.G., Teixeria, M.M., McNeice, C., Williams, T.J., Hellewell, P.G. & Doenhoff, M.J., Enhancement of Schistosoma mansoni infectivity by intradermal injections of larval extracts: A putative role for larval protease's, Journal of Infectious Diseases, 173, (6), 1996, p1460 - 1466Journal Article, 1996, URL
  • Fallon, P.G., Tao, L-F., Ismail, M.M. & Bennett, J.M., Schistosome resistance to praziquantel: fact or artifact, Parasitology Today, 12, (8), 1996, p316 - 320Journal Article, 1996, DOI
  • Fallon, P.G., Warren, J. & Behnke, J.M., Evaluation of immune dependence of anthelmintic treatment of Heligmosomoides polygyrus in CBA/Ca mice, International Journal for Parasitology, 26, (5), 1996, p557 - 560Journal Article, 1996, DOI
  • Fallon, P.G. & Hagan, P., Blood and Guts at Bangor, Parasitology Today, 12, (12), 1996, p460 - 462Journal Article, 1996, DOI
  • Webster, M., Fallon, P.G., Fulford, A.J.C., Butterworth, A.E., Ouma, J.H., Kimani, G. & Dunne, D.W., IgG4 and IgE responses to Schistosoma mansoni adult worms after treatment, Journal of Infectious Diseases, 175, 1997, p493 - 494Journal Article, 1997
  • Fallon, P.G., Mubarak, J., Fookes, R.E., Sturrock, R.F., Butterworth, A.E., Niang, M. & Doenhoff, M.J., Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates., Experimental Parasitology, 86, (1), 1997, p29 - 36Journal Article, 1997, DOI
  • Webster, M., Fulford, A.J.C., Fallon, P.G., Butterworth, A.E., Ouma, J.H., Kimani, G. & Dunne, D.W., Effect of Praziquantel or Oxamniquine on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm, Parasite Immunology, 19, (7), 1997, p333 - 335Journal Article, 1997, DOI
  • Fallon, P.G., Richardson, E.J., Jones, F.M. & Dunne, D.W., Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni, Clinical and Diagnostic Laboratory Immunology, 5, (2), 1998, p251 - 253Journal Article, 1998, URL
  • Fallon, P.G., Smith, P. & Dunne, D.W., Type 1 and Type 2 cytokine- producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection, European Journal of Immunology, 28, (4), 1998, p1408 - 1416Journal Article, 1998, DOI
  • Pereira, C., Fallon, P.G., Cornette, J., Capron, A., Doenhoff, M.J. & Pierce, R.J., Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni., Parasitology, 117, (1), 1998, p63 - 73Journal Article, 1998, DOI , URL
  • Fallon, P.G., Schistosome resistance to praziquantel, Drug Resistance Updates, 1, (4), 1998, p236 - 241Journal Article, 1998, DOI
  • McKenzie, G.J., Emson, C.L., Bell, S.E., Fallon, P.G., Krishna, M., Zurawski, G., Murray, R. Grencis, R. & McKenzie, A.N.J., Impaired development of Th2 cells in IL-13-deficient mice, Immunity, 9, (3), 1998, p423 - 432Journal Article, 1998, DOI , TARA - Full Text
  • Hamilton, J.V., Chiodini, P.L., Fallon, P.G. & Doenhoff, M.J., Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens, Parasitology, 118, 1999, p83 - 89Journal Article, 1999, DOI
  • Fallon, P.G. & Dunne, D.W., Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection, Journal of Immunology, 162, 1999, p4122 - 4132Journal Article, 1999, URL
  • McKenzie, G.J., Fallon, P.G., Emson, C.L., Grencis, R.K. & McKenzie, A.N.J., Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T Helper cell Type 2-mediated responses, Journal of Experimental Medicine, 189, 1999, p1565 - 1572Journal Article, 1999, DOI , URL
  • Fallon, P.G., Immunopathology of schistosomiasis: a cautionary tale of mice and men, Immunology Today, 21, (1), 2000, p29 - 35Journal Article, 2000, DOI
  • Fallon, P.G., Richardson, E.J., Smith, P. & Dunne, D.W., Elevated type 1, diminished type 2 cytokines and impaired antibody responses are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice, European Journal of Immunology, 30, (2), 2000, p470 - 480Journal Article, 2000, DOI
  • Fallon, P.G., Richardson, E.J., McKenzie, G.J. & McKenzie, A.N.J., Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent, Journal of Immunology, 164, 2000, p2585 - 2591Journal Article, 2000, URL
  • Townsend, M.J., Fallon, P.G., Matthews, D.J., Jolin, H.E. & McKenzie, A.N.J., T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary Th2 responses to immunization, Journal of Experimental Medicine, 191, (6), 2000, p1069 - 1075Journal Article, 2000, DOI
  • Fallon, P.G., Smith, P, Richardson, E.J., Jones, F.M., Faulkner, H.C., Van Snick, J., Renauld, J-C, Grencis, R.K. &, Dunne, D.W., Expression of Interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections, Infection and Immunity, 68, (10), 2000, p6005 - 6011Journal Article, 2000, DOI
  • Townsend, M.J., Fallon, P.G., Matthews, D.J., Smith, P., Jolin, H.E. & McKenzie, A.N.J., IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development, Immunity, 13, (4), 2000, p573 - 583Journal Article, 2000, DOI , TARA - Full Text
  • Fallon, P.G., Allen, R.L. & Rich, T., Primitive Toll signaling: bugs, flies, worms and man, Tends in Immunology, 22, (2), 2001, p63 - 66Journal Article, 2001, DOI
  • Fallon, P.G., Emson, C.L., Smith, P. & McKenzie, A.N.J., Interleukin-13 overexpression predisposes to anaphylaxis following antigen sensitization, Journal of Immunology, 166, (4), 2001, p2712 - 2716Journal Article, 2001, URL
  • Smith, P., Dunne, D.W. & Fallon, P.G., Defective in vivo induction of functional type 2 cytokine responses in aged mice, European Journal of Immunology, 31, (5), 2001, p1495 - 1502Journal Article, 2001, DOI
  • Hawerkamp HC, Dyer AH, Patil ND, McElheron M, O'Dowd N, O'Doherty L, Mhaonaigh AU, George AM, O'Halloran AM, Reddy C, Kenny RA, Little MA, Martin-Loeches I, Bergin C, Kennelly SP, Donnelly SC, Bourke NM, Long A, Sui J, Doherty DG, Conlon N, Cheallaigh CN, Fallon PG., Characterisation of the pro-inflammatory cytokine signature in severe COVID-19., Frontiers in Immunology, 14, 2023, p1170012-Journal Article, 2023, URL
  • Roberts J, Chevalier A, Hawerkamp HC, Yeow A, Matarazzo L, Schwartz C, Hams E, Fallon PG., Retinoic Acid-Related Orphan Receptor " Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation., Journal of immunology (Baltimore, Md. : 1950), 211, (4), 2023, p626-632Journal Article, 2023, DOI
  • Yin M, Wadhwa R, Marshall JE, Gillis CM, Kim RY, Dua K, Palsson-McDermott EM, Fallon PG, Hansbro PM, O'Neill LAJ., 4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development., Journal of immunology (Baltimore, Md. : 1950), 212, (1), 2024, p13-23Journal Article, 2024, DOI
  • Klement JD, Redd PS, Lu C, Merting AD, Poschel DB, Yang D, Savage NM, Zhou G, Munn DH, Fallon PG, Liu K., Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment., Cancer cell, 41, (3), 2023, p620-636.e9Journal Article, 2023, DOI
  • Ward SE, Guest T, Byrne C, Lopes P, O'Sullivan JM, Doherty D, O'Connell D, Gutierrez Llaneza S, Chion A, Fazavana J, Fallon PG, Preston RJS, Johnsen JM, Pipe SW, Turecek PL, O'Donnell JS, iPATH Study Group., Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report., Arteriosclerosis, thrombosis, and vascular biology, 43, (4), 2023, p540-546Journal Article, 2023, DOI
  • Dietschmann A, Ruhl A, Murray PJ, Günther C, Becker C, Fallon P, Voehringer D., Th2-dependent disappearance and phenotypic conversion of mouse alveolar macrophages., European journal of immunology, 53, (10), 2023, pe2350475Journal Article, 2023, DOI
  • Lavazais S, Jargosch M, Dupont S, Labéguère F, Menet C, Jagerschmidt C, Ohm F, Kupcsik L, Parent I, Cottereaux C, Marsais F, Oste L, Van de Water A, Christophe T, De Vos S, Fallon P, Lauffer F, Clément-Lacroix P, Eyerich K, Brys R., IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases., Science translational medicine, 15, (683), 2023, peabj3289Journal Article, 2023, DOI
  • Szeto ACH, Clark PA, Ferreira ACF, Heycock M, Griffiths EL, Jou E, Mannion J, Luan SL, Storrar S, Knolle MD, Kozik P, Jolin HE, Fallon PG, McKenzie ANJ., Mef2d potentiates type-2 immune responses and allergic lung inflammation., Science (New York, N.Y.), 384, (6703), 2024, peadl0370Journal Article, 2024, DOI
  • Tchen J, Simon Q, Chapart L, Thaminy MK, Vibhushan S, Saveanu L, Lamri Y, Saidoune F, Pacreau E, Pellefigues C, Bex-Coudrat J, Karasuyama H, Miyake K, Hidalgo J, Fallon PG, Papo T, Blank U, Benhamou M, Hanouna G, Sacre K, Daugas E, Charles N., PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus., Nature communications, 15, (1), 2024, p3389Journal Article, 2024, DOI
  • Schneider AK, Domingos-Pereira S, Cesson V, Polak L, Fallon PG, Zhu J, Roth B, Nardelli-Haefliger D, Derré L., Type 2 innate lymphoid cells are not involved in mouse bladder tumor development, Frontiers in Immunology, 14, 2024, p1335326Journal Article, 2024, DOI
  • Achilleas Floudas, Gabriella Aviello, Christian Schwartz, Ian B. Jeffery, Paul W. O'Toole, Padraic G. Fallon, De'Broski R. Herbert, Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis, Infection and Immunity, 2019Journal Article, 2019
  • Jacob P. Thyssen, Ivone Jakasa, Christoph Riethmüller, Michael P. Schön, Andrea Braun, Marek Haftek, Padraic G. Fallon, Jacek Wróblewski, Hieronim Jakubowski, Leopold Eckhart, Wim Declercq, Sjors Koppes, Kristiane A. Engebretsen, Charlotte Bonefeld, Alan D. Irvine, Sokhna Keita-Alassane, Michel Simon, Hiroshi Kawasaki, Akiharu Kubo, Masayuki Amagai, Takeshi Matsui, Sanja Kezic, Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice, Journal of Investigative Dermatology, 2019Journal Article, 2019
  • Smith, P., Fallon, R.E., Mangan, N.E., Walsh, C.M., Saraiva, M., Sayers, J.R., McKenzie, A.N., Alcami, A. & Fallon P.G. , Schistosoma mansoni secretes a chemokine binding protein with anti-inflammatory activity. , Journal of Experimental Medicine , 202, (10), 2005, p1319 - 1325Journal Article, 2005, DOI
  • Mangan, N.E., Rooijen, N. McKenzie, A.N.J. & Fallon, P.G. , Helminth-modified pulmonary response protects mice from allergen-induced airway hyper-responsiveness. , The Journal of Immunology, 176, 2006, p138 - 147Journal Article, 2006, URL
  • Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN., Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion., The Journal of Experimental Medicine, 203, (4), 2006, p1105 - 1116Journal Article, 2006, DOI , TARA - Full Text
  • Fallon, P.G., Alcami. A., Pathogen-dervied immunomodulatory molecules: future immunotherapeutics?, Trends in Immunology, 27, (10), 2006, p470 - 476Journal Article, 2006, DOI
  • Fallon, P.G., Mangan, N.E., Suppression of TH2-type allergic inflammation by helminth infection., Nature Reviews in Immunology, 7, 2007, p220 - 230Journal Article, 2007, DOI
  • Smith, P., Mangan, N.E., Walsh, C.M, Fallon, R.E., van Rooijen, N., McKenzie, & Fallon, P.G. , Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. , Journal of Immunology , 178, (7), 2007, p4557 - 4566Journal Article, 2007, URL
  • Walsh, C.M, Smith, P., & Fallon, P.G. , Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice. , Parasite Immunology, 29, (6), 2007, p293 - 308Journal Article, 2007, DOI
  • Mangan, N.E., Dasvarma, A., McKenzie, A.N. & Fallon, P.G. , T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. , European Journal of Immunology , 37, (5), 2007, p1302 - 1312Journal Article, 2007, DOI
  • Walsh CM, Smith P, Fallon PG., Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice, Parasite Immunology, 29, (6), 2007, p293 - 308Journal Article, 2007, DOI
  • Moens L, Jeurissen A, Wuyts G, Fallon PG, Louis B, Ceuppens JL, Bossuyt X, Specific intracellular adhesion molecule-grabbing nonintegrin R1 is not involved in the murine antibody response to pneumococcal polysaccharides., Infection and Immunity, 75, (12), 2007, p2495 - 2506Journal Article, 2007, DOI , TARA - Full Text
  • Feighery LM, Smith P, O'Mahony L, Fallon PG, Brayden DJ., Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease., Digestive Diseases and Sciences, 53, (9), 2007, p2495 - 2506Journal Article, 2007, DOI
  • Cummins EP, Seeballuck F, Keely SJ, Mangan NE, Callanan JJ, Fallon PG, Taylor CT, The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis, Gastroenterology, 134, (1), 2008, p156 - 165Journal Article, 2008, DOI
  • Adams AE, Carroll AM, Fallon PG, Porter RK., Mitochondrial uncoupling protein 1 expression in thymocytes., Biochimica et Biophysica Acta (BBA) - Bioenergetics , 1777, (7-8), 2008, p772 - 776Journal Article, 2008, DOI , TARA - Full Text
  • Saunders SP, Walsh CM, Barlow JL, Mangan NE, Taylor PR, McKenzie AN, Smith P, Fallon PG, The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection, Infection and Immunity, 77, (1), 2009, p399 - 404Journal Article, 2009, DOI , TARA - Full Text
  • Fallon PG, Why does work on same mouse models give different results?, Nature, 454, (7205), 2008, p691 - 691Journal Article, 2008, DOI
  • Ruiz Marquez JF, Radics G, Windle H, Serra HO, Simplicio AL, Kedziora K, Fallon PG, Kelleher DP, Gilmer GF, Design, Synthesis, and Pharmacological Effects of a Cyclization-activated Steroid Prodrug for Colon Targeting in Inflammatory Bowel Disease, Journal of Medicinal Chemistry, 52, (10), 2009, p3205 - 3211Journal Article, 2009, DOI
  • Fallon, PG, Sasaki, T, Sandilands, A, Campbell, LE, Saunders, SP, Mangan, NE, Callanan, JJ, Kawasaki, H, Shiohama, A, Kubo, A, Sundberg, JP, Presland, RB, Fleckman, P, Shimizu, N, Kudoh, J, Irvine, AD, Amagai, M, McLean, WH, A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming., Nature Genetics, 41, (5), 2009, p602 - 608Journal Article, 2009, DOI
  • Alison E. Adams, Orla Hanrahan, Derek N. Nolan, H. Paul Voorheis, Padraic Fallon and Richard K. Porter, Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy , Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777, (2), 2008, p115 - 117Journal Article, 2008, DOI , TARA - Full Text
  • Adisakwattana P, Saunders SP, Nel HJ, Fallon PG., Helminth-derived immunomodulatory molecules., by Adisakwattana P, Saunders SP, Nel HJ, Fallon PG. , Advances in experimental medicine and biology , 666, 2009, p95-107Review, 2009, DOI
  • Pathogen-derived immunomodulatory molecules. Preface. in, editor(s)Fallon, P.G. , Pathogen-derived immunomodulatory molecules. , USA, Landes Bioscience, 2009, [Fallon, P.G.]Book Chapter, 2009
  • Smith P, Mangan NE, Fallon PG., Generation of parasite antigens for use in Toll-like receptor research., Methods Molecular Biology, 517, 2009, p401 - 413Journal Article, 2009, DOI
  • Saunders SP, Barlow JL, Walsh CM, Bellsoi A, Smith P, McKenzie AN, Fallon PG., C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide., Journal Immunology, 184, (5), 2010, p2627 - 2637Journal Article, 2010, DOI
  • Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN., Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity., Nature, 464, 2010, p1367 - 1310Journal Article, 2010, DOI , TARA - Full Text
  • Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG., Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model., Journal of Allergy and Clinical Immunology, 125, (5), 2010, p1114 - 1124Journal Article, 2010, DOI , URL , TARA - Full Text
  • Court N, Vasseur V, Vacher R, Frémond C, Shebzukhov Y, Yeremeev VV, Maillet I, Nedospasov SA, Gordon S, Fallon PG, Suzuki H, Ryffel B, Quesniaux VF., Partial Redundancy of the Pattern Recognition Receptors, Scavenger Receptors, and C-Type Lectins for the Long-TermControl of Mycobacterium tuberculosis Infection., Journal of Immunology, 184, 2010, p7057 -7070Journal Article, 2010, DOI
  • Murtaza M. Tambuwala, Eoin P. Cummins, Colin R. Lenihan, Judith Kiss, Markus Stauch, Carsten C. Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P. Saunders, Patrick H. Maxwell, Peter Carmeliet, Padraic G. Fallon, Martin Schneider, Cormac T. Taylor, Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function, Gastroenterology, 139, (6), 2010, p2093-2101Journal Article, 2010, DOI , URL , TARA - Full Text
  • Alexander Ludwig, Grant P. Otto, Kirsi Riento, Emily Hams, Padraic G. Fallon, and Ben J. Nichols, Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment, Journal of Cell Biology, 191, (4), 2010, p771-781Journal Article, 2010, DOI , URL , TARA - Full Text
  • Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207Journal Article, 2011, DOI , URL , TARA - Full Text
  • Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy, Jennifer K. Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J. O'Connell, Brian Keogh, Charles O. Morton, Thomas R. Rogers, Padraic G. Fallon, Luke A. O'Neill, Dermot Kelleher, Christine E. Loscher , A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins, PLoS Pathogens, 7, (6, e1002076), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
  • Emily Hams, Mark J. McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen and Padraic G. Fallon, Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells , The Journal of Immunology, 186, (10), 2011, p5648-5655Journal Article, 2011, URL , TARA - Full Text
  • Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne AT, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG ., The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells., Shock, 36, (3), 2011, p295-302Journal Article, 2011, DOI , URL , TARA - Full Text
  • Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG. , Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. , Journal of Immunology, 186, (8), 2011, p4631-4639Journal Article, 2011, URL , TARA - Full Text
  • Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA., SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses., Journal of Experimental Medicine, 208, (7), 2011, p1523-1531Journal Article, 2011, DOI , URL , TARA - Full Text
  • Downer EJ, Clifford E, Gran B, Nel HJ, Fallon PG, Moynagh PN , Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis., The Journal of Biological Chemistry, 286, (12), 2011, p10316-10328Journal Article, 2011, DOI , URL , TARA - Full Text
  • Enoksson M, Lyberg K, Möller-Westerberg C, Fallon PG, Nilsson G, Lunderius-Andersson C., Mast Cells as Sensors of Cell Injury through IL-33 Recognition., Journal of Immunology, 186, (4), 2011, p2523-2528Journal Article, 2011, DOI
  • Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O'Connor A, Gallagher WM, Lenihan CR, Garvey JF, Howell K, Fallon PG, Cummins EP, Taylor CT., An intact canonical NF-?B pathway is required for inflammatory gene expression in response to hypoxia., Journal of Immunology, 186, (2), 2011, p1091-1096Journal Article, 2011, DOI
  • Miajlovic H, Fallon PG, Irvine AD, Foster TJ., Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus, Journal of Allergy and Clinical Immunology, 126, (6), 2011, p1184-1190Journal Article, 2011, DOI , TARA - Full Text
  • Viejo-Borbolla A, Martinez-Martín N, Nel HJ, Rueda P, Martín R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcamí A., Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses., PLoS Pathogens, 8, (2), 2012, pFeb;8(2):e1002497Journal Article, 2012, TARA - Full Text
  • Russell SE, Moore AC, Fallon PG, Walsh PT, Soluble IL-2R" (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice., PloS one, 7, (10), 2012, pe47748Journal Article, 2012, DOI , TARA - Full Text
  • Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD, Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency., The Journal of allergy and clinical immunology, 129, (4), 2012, p1031-9.e1Journal Article, 2012, DOI , TARA - Full Text
  • Kelly OB, Mroz MS, Ward JB, Colliva C, Scharl M, Pellicciari R, Gilmer JF, Fallon PG, Hofmann AF, Roda A, Murray FE, Keely SJ., Ursodeoxycholic acid attenuates colonic epithelial secretory function., Journal of Physiology, 2013, p2307-2318Journal Article, 2013, DOI , TARA - Full Text
  • Verma NK, Dempsey E, Long A, Davies A, Barry SP, Fallon PG, Volkov Y, Kelleher D, Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-ß signaling., The Journal of biological chemistry, 287, (32), 2012, p27204-16Journal Article, 2012, DOI , TARA - Full Text
  • Yang S, Wang B, Humphries F, Jackson R, Healy M, Bergin R, Aviello G, Hall B, McNamara D, Walsh P, Russell S, Hussey S, O'Sullivan M, Darby T, Quinlan A, Shanahan F, Melgar S,Fallon PG, Moynagh P, Pellino3 ubiquitinates RIP2 and mediates NOD2-induced signaling and protective effects in colitis, Nature Immunology, 14, (9), 2013, p927 - 936Journal Article, 2013, DOI , TARA - Full Text
  • Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, Fallon PG, Walsh PT, Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by "" T Cells., Journal of immunology (Baltimore, Md. : 1950), 191, (6), 2013, p3337-3346Journal Article, 2013, DOI , TARA - Full Text
  • Gleeson EM, O'Donnell JS, Hams E, Ni Ainle F, Kenny BA, Fallon PG, Preston RJ. , Activated Factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine prodution from LPS-stimulated myeloid cells., Haematologica, 99, (1), 2014, p185 - 193Journal Article, 2014, DOI , TARA - Full Text
  • Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67Journal Article, 2014, DOI , TARA - Full Text
  • Saunders, S.P., Goh, C.S.M., Brown, S.J., Palmer, C.N.A., Porter, R.M., Cole, C., Campbell, L.E., Gierlinski, M., Barton, G.J., Schneider, G., Balmain, A., Prescott, A.R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y.-A., Tavendale, R., Mukhopadhyay, S., Turner, S.W., Madhok, V.B., Sullivan, F.M., Relton, C., Burn, J., Meggitt, S., Smith, C.H., Allen, M.A., Barker, J.N.W.N., Reynolds, N.J., Cordell, H.J., Irvine, A.D., McLean, W.H.I., Sandilands, A., Fallon, P.G., Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects, Journal of Allergy and Clinical Immunology, 132, (5), 2013, p1121-1129Journal Article, 2013, DOI , TARA - Full Text
  • Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-Journal Article, 2014, DOI , TARA - Full Text
  • Khan AR, Amu S, Saunders SP, Fallon PG, The generation of regulatory B cells by helminth parasites., Methods in molecular biology (Clifton, N.J.), 1190, 2014, p143-62Journal Article, 2014, DOI
  • Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, Huang LC, Johnson D, Scanlon ST, McKenzie AN, Fallon PG, Ogg GS, A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis., The Journal of experimental medicine, 210, (13), 2013, p2939-50Journal Article, 2013, DOI , TARA - Full Text
  • Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG, IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis., Proceedings of the National Academy of Sciences of the United States of America, 111, (1), 2014, p367-72Journal Article, 2014, DOI , TARA - Full Text
  • Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN., MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion., Immunity, 41, 2014, p283 - 295Journal Article, 2014, TARA - Full Text
  • Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Löhning M, Belkaid Y, Fallon PG, Powrie F., The alarmin IL-33 promotes regulatory T-cell function in the intestine., Nature, Jul 16, 2014Journal Article, 2014, DOI , TARA - Full Text
  • Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC., Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis., Aging Cell, 14, 2014, p69 - 708Journal Article, 2014, DOI , TARA - Full Text
  • Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778Journal Article, 2014, DOI , TARA - Full Text
  • Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA., Btk regulates macrophage polarization in response to lipopolysaccharide., PloS One, 21, 2014, pe85834.Journal Article, 2014, DOI , TARA - Full Text
  • Hams E, Locksley RM, McKenzie AN, Fallon PG., Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice., Journal of Immunology, 191, 2013, p5349 - 5353Journal Article, 2013, DOI , TARA - Full Text
  • Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT., Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways., Proc Natl Acad Sci U S A, 110, 2013, p18490 - 18495Journal Article, 2013, DOI , TARA - Full Text
  • Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, Donowitz M, Fallon PG, Keely SJ., Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo., Gut, 63, 2014, p808 - 817Journal Article, 2014, DOI , TARA - Full Text
  • O'Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, Simpson AJ, Millar AB, McGrath EE, Whyte MK, Hirani N, Hogaboam CM, Donnelly SC., The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis., Am J Respir Crit Care Med., 188, 2013, p1442 - 1450Journal Article, 2013, DOI
  • Hams E, Aviello G, Fallon PG., The schistosoma granuloma: friend or foe?, Front Immunol, 15, 2013, p48-Journal Article, 2013, DOI , TARA - Full Text
  • Aviello G, Amu S, Saunders SP, Fallon PG., A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner., Phytother Res., 28, 2014, p300 - 304Journal Article, 2014, DOI , TARA - Full Text
  • Sedhom MA, Pichery M, Murdoch JR, Foligné B, Ortega N, Normand S, Mertz K, Sanmugalingam D, Brault L, Grandjean T, Lefrancais E, Fallon PG, Quesniaux V, Peyrin-Biroulet L, Cathomas G, Junt T, Chamaillard M, Girard JP, Ryffel B., Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice., Gut, 62, 2013, p1714 - 1723Journal Article, 2013, DOI , TARA - Full Text
  • Scalfone LK, Nel HJ, Gagliardo LF, Cameron JL, Al-Shokri S, Leifer CA, Fallon PG, Appleton JA., Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis., Infect Immun, 81, 2013, p1354 - 1363Journal Article, 2013, DOI , TARA - Full Text
  • Knosp CA, Schiering C, Spence S, Carroll HP, Nel HJ, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald DC, Powrie F, Fallon PG, Johnston JA, Kissenpfennig A., Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2., J. Immunol., 190, 2013, p3235 - 3245Journal Article, 2013, DOI , TARA - Full Text
  • Khan AR, Fallon PG., Helminth therapies: translating the unknown unknowns to known knowns., Int. J. Para., 2013, p293 - 299Review Article, 2013, DOI , TARA - Full Text
  • Enoksson M, Möller-Westerberg C, Wicher G, Fallon PG, Forsberg-Nilsson K, Lunderius-Andersson C, Nilsson G., Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent., Blood, 121, 2013, p530 - 536Journal Article, 2013, DOI , TARA - Full Text
  • Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H, Kubota Y., Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies., Am. J. Path., 181, 2012, p969 - 977Journal Article, 2012, DOI
  • Young A, Linehan E, Hams E, O'Hara Hall AC, McClurg A, Johnston JA, Hunter CA, Fallon PG, Fitzgerald DC., Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27., J. Immunol., 186, 2012, p2079 - 2083Journal Article, 2012, DOI
  • Hams E, Fallon PG., Innate type 2 cells and asthma. , Curr. Opin. Pharmacol., 12, 2012, p503 - 509Review Article, 2012, DOI
  • Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN., The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α., J Biol Chem., 287, 2012, p25440 - 25553Journal Article, 2012, DOI
  • Bowie RV, Donatello S, Lyes C, Owens MB, Babina IS, Hudson L, Walsh SV, O'Donoghue DP, Amu S, Barry SP, Fallon PG, Hopkins AM., Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier., Am J Physiol Gastrointest Liver Physiol., 302, 2012, p781 - 791Journal Article, 2012, DOI
  • Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD., The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses., Science, 335, 2012, p984 - 989Journal Article, 2012, DOI
  • Wong SH, Walker JA, Jolin HE, Drynan LF, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, McKenzie AN., Transcription factor RORα is critical for nuocyte development., Nature Immunology, 13, 2012, p229 - 236Journal Article, 2012, DOI
  • Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN., Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia., Nat Commun, 3, 2012, p1119Journal Article, 2012, DOI
  • Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P., Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice., PloS Pathog, 8, 2012, p1002883Journal Article, 2012, DOI , TARA - Full Text
  • Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT, Regulation of IL-1ß-induced NF-"B by hydroxylases links key hypoxic and inflammatory signaling pathways., Proceedings of the National Academy of Sciences of the United States of America, 110, (46), 2013, p18490-5Journal Article, 2013, DOI , TARA - Full Text
  • Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG, PD-L1(hi) B cells are critical regulators of humoral immunity., Nature communications, 6, 2015, p5997Journal Article, 2015, DOI , TARA - Full Text

Recognition

  • Member Royal Irish Academy (MRIA) 2014
  • Stokes Professorship from Science Foundation Ireland. 2008
  • Fellow Trinity College Dublin (FTCD) 2009