Dr. Mary O'Sullivan

• O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J., Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis., American Journal of Respiratory and Critical Care Medicine, 190, (12), 2014, p1430 - 1436Journal Article, 2014, URL
• Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449Journal Article, 2016, DOI , URL , TARA - Full Text
• Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379Journal Article, 2016, URL , TARA - Full Text
• Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP, Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF"B and Autophagy Dependent Bacillary Killing., PloS one, 11, (2), 2016, pe0149167Journal Article, 2016, DOI , URL , TARA - Full Text
• Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152Journal Article, 2016, URL
• O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J, Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery., Advanced Drug Delivery Reviews, 102, 2016, p33 - 54Journal Article, 2016, URL
• Cambier CJ, O'Leary SM, O'Sullivan MP, Keane J, Ramakrishnan L., Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages., Immunity, 47, (3), 2017, p552 - 565Journal Article, 2017, DOI , TARA - Full Text
• O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European Journal of Pharmaceutics and Biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165Journal Article, 2019, DOI
• O'Sullivan, M. P., O'Leary, S., Prentice, M. B., Keane, J., Macrophage Responses to a Clinical Isolate of Mycobacterium tuberculosis, Irish Journal of Medical Science, 180, 2011, pS444Journal Article, 2011
• Lawlor, C., O'Sullivan, M., O'Leary, S., Bowie, R., Keane, J., Gallagher, P. J., Cryan, S. A., A study of the interaction of novel, coated microparticles with alveolar macrophages and their application in tuberculosis treatment via inhalation, Drug Discovery Today, 15, (23-24), 2010, p1107Journal Article, 2010
• O'Sullivan, M. P., Ryan, R., O'Leary, S., Keane, J., Human Macrophages Infected with Mycobacterium tuberculosis Undergo a Non-Apoptotic Form of Cell Death., American Journal of Respiratory and Critical Care Medicine, 179, 2009Journal Article, 2009
• O'Leary S, Bahlool AZ, O'Connor G, Cryan SA, Keane JM, O'Sullivan MP., An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis., Journal of visualized experiments : JoVE, (174), 2021Journal Article, 2021, DOI
• Bahlool AZ, Fattah S, O'Sullivan A, Cavanagh B, MacLoughlin R, Keane J, O'Sullivan MP, Cryan SA., Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis., Pharmaceutics, 14, (8), 2022, p1745Journal Article, 2022, DOI
• Bahlool AZ, Grant C, Cryan SA, Keane J, O'Sullivan MP., All trans retinoic acid as a host-directed immunotherapy for tuberculosis., Curr Res Immunol, 3, 2022, p54-72Journal Article, 2022, DOI
• Bedard M, van der Niet S, Bernard EM, Babunovic GH, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB., A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages., The Journal of clinical investigation, 2023, pe161944Journal Article, 2023, DOI
• Triglia D, Gogan KM, Keane J, O'Sullivan MP., Glucose metabolism and its role in the maturation and migration of human CD1c⁺ dendritic cells following exposure to BCG., Frontiers in cellular and infection microbiology, 13, 2023, p1113744Journal Article, 2023, DOI
• Bahlool AZ, Cavanagh B, Sullivan AO, MacLoughlin R, Keane J, Sullivan MPO, Cryan SA., Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2024, p106734Journal Article, 2024, DOI
• Kelly, DM, ten Bokum, AM, O'Leary, SM, O'Sullivan, MP, Keane, J, Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection., Infection and Immunity, 76, (1), 2008, p351 - 360Journal Article, 2008, DOI , TARA - Full Text
• Tyner, JW, Uchida, O, Kajiwara, N, Kim, EY, Patel, AC, O'Sullivan, MP, Walter, MJ, Schwendener, RA, Cook, DN, Danoff, TM, Holtzman, MJ, CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection., Nature Medicine, 11, (11), 2005, p1180 - 1187Journal Article, 2005, DOI
• O'Sullivan, MP, Tyner, JW, Holtzman, MJ, Apoptosis in the airways: another balancing act in the epithelial program., American Journal of Respiratory Cell and Molecular Biology, 29, (1), 2003, p3 - 7Journal Article, 2003, DOI
• Holtzman, MJ, Morton, JD, Shornick, LP, Tyner, JW, O'Sullivan, MP, Antao, A, Lo, M, Castro, M, Walter, MJ, Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm., Physiological Reviews, 82, (1), 2002Journal Article, 2002, DOI
• O'Sullivan, MP, O'Leary, S, Kelly, DM, Keane, J, A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection., Infection and Immunity, 75, (4), 2007, p1984 - 1993Journal Article, 2007, DOI , TARA - Full Text
• Jayaraman, S, Castro, M, O'Sullivan, M, Bragdon, MJ, Holtzman, MJ, Resistance to Fas-mediated T cell apoptosis in asthma., Journal of Immunology (Baltimore, Md. : 1950), 162, (3), 1999Journal Article, 1999
• Zhang, V, O'Sullivan, M, Hussain, H, Roswit, WT, Holtzman, MJ, Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2., Biochemical and Biophysical Research Communications, 227, (2), 1996Journal Article, 1996, DOI
• Mercedes González-Juarrero, and Mary P. O'Sullivan, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells, Tuberculosis, 91, (1), 2011, p86-92Journal Article, 2011, DOI , URL , TARA - Full Text
• González-Juarrero M, O'Sullivan MP, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells., Tuberculosis (Edinburgh, Scotland), 91, (1), 2010, p86 - 92Journal Article, 2010, DOI
• Lawlor C, Kelly C, O'Leary S, O'Sullivan MP, Gallagher PJ, Keane J, Cryan SA., Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of MTb., Tuberculosis, 91, (1), 2011, p93 - 97Journal Article, 2011
• O'Leary S, O'Sullivan MP, Keane J., IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages., American Journal of Respiratory Cell and Molecular Biology, 45, (1), 2011, p172 - 180Journal Article, 2011
• Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA, The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages., Molecular Pharmaceutics, 8, (4), 2011, p1100 - 1112Journal Article, 2011, DOI
• Lawlor C, O'Sullivan MP, Rice B, Dillon P, Gallagher PJ, O'Leary S, Shoyele S, Keane J, Cryan SA, Therapeutic aerosol bioengineering of targeted, inhalable microparticle formulations to treat Mycobacterium tuberculosis (MTb)., Journal of Materials Science. Materials in Medicine, 23, (1), 2012, p89 - 98Journal Article, 2012, DOI
• Ryan RC, O'Sullivan MP, Keane J, Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells., BMC Microbiology, 11, 2011, p237-Journal Article, 2011, TARA - Full Text
• O'Sullivan M, Clancy JM, Roche JF, Corrigan OI, Controlled delivery of oestradiol-17-b from silastic implants: in vitro and in vivo evaluation., European Journal of Drug Metabolism and Pharmacokinetics, Spec No 3, 1991, p478-82Journal Article, 1991
• Verma NK, Conroy J, Lyons PE, Coleman J, O'Sullivan MP, Kornfeld H, Kelleher D, Volkov Y, Autophagy induction by silver nanowires: A new aspect in the biocompatibility assessment of nanocomposite thin films., Toxicology and Applied Pharmacology, 264, (3), 2012, p451-61Journal Article, 2012, DOI

• Regulation of epithelial-leukocyte interaction and epithelial immune-response genes in, Asthma and Rhinitis, Cambridge, MA, Blackwell Scientific, 2000, pp784 - 800, [MJ Holtzman, M Castro, DC Look, M O'Sullivan, MJ Walter]Book Chapter

• Title

  Leveraging autophagy to direct an inhales TB vaccine to dendritic cell autophagosomes for better antigen presentation
  Summary
  Funding Agency

  Dean's Research Initiatives Research Fund
  Date From

  2016
  Date To

  2017
• Title

  Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
  Summary
  Funding Agency

  TTMI BEHR funding
• Title

  Defining the role of human dendritic cell subsets in host immune responses to mycobacterial infection.
  Summary
  Funding Agency

  HRB
  Date From

  2013
  Date To

  31-12-2017
• Title

  Development of inhaled medicines for treatment of Tuberculosis
  Summary
  Funding Agency

  HRB
  Date From

  2012
  Date To

  2016
• Title

  Particle engineering to target interferon-gamma to alveolar macrophages for the adjunct treatment of multi-drug resistant tuberculosis
  Summary
  Funding Agency

  HRB
  Date From

  2007
  Date To

  2011
• Title

  Correcting Pulmonary Immunity through manipulation of CFTR
  Summary
  Funding Agency

  HRCI/HRB
  Date From

  2021
  Date To

  2023
• Title

  Immunometabolic manipulation of pulmonary immunity - towards TB host directed therapy
  Summary
  Funding Agency

  HRB
  Date From

  2019
• Title

  The mechanism of macrophage cell death in response to M. tuberculosis infection and its role in the fate of mycobacteria
  Summary
  Funding Agency

  SFI
  Date From

  2008
  Date To

  2012
• Title

  Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
  Summary
  Funding Agency

  Trinity Translational Medicine Institute Bursary
• Title

  Towards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection
  Summary
  Funding Agency

  Health Research Board/ Irish Thoracic Society
  Date From

  1-1-2017
  Date To

  31-12-2018

Immunology, Medical and biomedical engineering, Biochemistry and cell biology,

• Dean's Research Initiatives Research Fund Bursary February 2016
• American Thoracic Society Travel Award 2007
• Irish Thoracic Society Award for Best Oral Presentation 2008

• American Thoracic Society
• American Association for the Advancement of Science Present

• Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
• Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
• Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
• Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
• Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
• Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004