Professor Matthew Campbell
Professor, Genetics
Professor, Trinity Inst. of Neurosciences (TCIN)
Publications and Further Research Outputs
Peer-Reviewed Publications
Cathomas F, Lin HY, Chan KL, Li L, Parise LF, Alvarez J, Durand-de Cuttoli R, Aubry AV, Muhareb S, Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Pérez C, Parise EM, Wilk CM, Kaster MP, Wang J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez N, Campbell M, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ., Circulating myeloid-derived MMP8 in stress susceptibility and depression., Nature, 626, (8001), 2024, p1108-1115
Cafri, N. and Mirloo, S. and Zarhin, D. and Kamintsky, L. and Serlin, Y. and Alhadeed, L. and Goldberg, I. and Maclean, M.A. and Whatley, B. and Urman, I. and Doherty, C.P. and Greene, C. and Behan, C. and Brennan, D. and Campbell, M. and Bowen, C. and Ben-Arie, G. and Shelef, I. and Wandschneider, B. and Koepp, M. and Friedman, A. and Benninger, F., Imaging bloodâ"brain barrier dysfunction in drug-resistant epilepsy: A multi-center feasibility study, Epilepsia, 2024
Vázquez-Liébanas E, Mocci G, Li W, Laviña B, Reddy A, O'Connor C, Hudson N, Elbeck Z, Nikoloudis I, Gaengel K, Vanlandewijck M, Campbell M, Betsholtz C, Mäe MA., Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage., Cell reports, 43, (3), 2024, p113911
Greene, C. and Rebergue, N. and Fewell, G. and Janigro, D. and Godfrin, Y. and Campbell, M. and Lemarchant, S., NX210c drug candidate peptide strengthens mouse and human blood-brain barriers, Fluids and Barriers of the CNS, 21, (1), 2024
Hashimoto Y, Campbell M., Eyes on glutamate in angiogenesis and barrier formation., Neuron, 112, (12), 2024, p1895-1897
Hashimoto Y, Greene C, Hanley N, Hudson N, Henshall D, Sweeney KJ, O'Brien DF, Campbell M., Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier., Fluids and barriers of the CNS, 21, (1), 2024, p52
Hashimoto Y, Besmond C, Boddaert N, Munnich A, Campbell M., A loss of function mutation in CLDN25 causing Pelizaeus-Merzbacher-like leukodystrophy., Human molecular genetics, 33, (12), 2024, p1055-1063
Greene C., Connolly R., Brennan D., Laffan A., O'Keeffe E., Zaporojan L., O'Callaghan J., Thomson B., Connolly E., Argue R., Meaney J.F.M., Martin-Loeches I., Long A., Cheallaigh C.N., Conlon N., Doherty C.P., Campbell M., Correction to: Blood"brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment (Nature Neuroscience, (2024), 27, 3, (421-432), 10.1038/s41593-024-01576-9), Nature Neuroscience, 27, (5), 2024, p1019-
Greene C, Connolly R, Brennan D, Laffan A, O'Keeffe E, Zaporojan L, O'Callaghan J, Thomson B, Connolly E, Argue R, Meaney JFM, Martin-Loeches I, Long A, Cheallaigh CN, Conlon N, Doherty CP, Campbell M., Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment., Nature neuroscience, 27, (3), 2024, p421-432
ORiordan, M.M. and Behan, C. and OLeary, F. and Hudson, N. and Doherty, C.P. and Cahill, M.T. and Campbell, M., Multimodal Analysis of the Retinal Manifestations of Tuberous Sclerosis Complex: A Case Series, Ophthalmic Surgery Lasers and Imaging Retina, 55, (10), 2024, p568-574
Porkoláb G, Mészáros M, Szecskó A, Vigh JP, Walter FR, Figueiredo R, Kálomista I, Hoyk Z, Vizsnyiczai G, Gróf I, Jan JS, Gosselet F, Pirity MK, Vastag M, Hudson N, Campbell M, Veszelka S, Deli MA., Synergistic induction of blood-brain barrier properties., Proceedings of the National Academy of Sciences of the United States of America, 121, (21), 2024, pe2316006121
Wakonigg Alonso C, McElhatton F, O'Mahony B, Campbell M, Pollak TA, Stokes PRA., The blood-brain barrier in bipolar disorders: A systematic review., Journal of affective disorders, 361, 2024, p434-444
Henderson, J. and O'Callaghan, J. and Campbell, M., Gene therapy for glaucoma: Targeting key mechanisms, Vision Research, 225, (108502), 2024
Greene C, Connolly R, Brennan D, Laffan A, O'Keeffe E, Zaporojan L, O'Callaghan J, Thomson B, Connolly E, Argue R, Meaney JFM, Martin-Loeches I, Long A, Cheallaigh CN, Conlon N, Doherty CP, Campbell M., Author Correction: Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment., Nature neuroscience, 27, (5), 2024, p1019
Dion-Albert, L. and Dudek, K.A. and Russo, S.J. and Campbell, M. and Menard, C., Neurovascular adaptations modulating cognition, mood, and stress responses, Trends in Neurosciences, 46, (4), 2023, p276-292
Muñoz-Wolf, N. and Ward, R.W. and Hearnden, C.H. and Sharp, F.A. and Geoghegan, J. and O'Grady, K. and McEntee, C.P. and Shanahan, K.A. and Guy, C. and Bowie, A.G. and Campbell, M. and Roces, C.B. and Anderluzzi, G. and Webb, C. and Perrie, Y. and Creagh, E. and Lavelle, E.C., Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles, Cell Reports Medicine, 4, (1), 2023
Brennan, D. and Delaney, C. and Farrell, M. and Campbell, M. and Doherty, C.P., Polypathology-associated neurodegeneration after remote head injury, Clinical Neuropathology, 42, (6), 2023, p201-211
Lay, C.S. and Thomas, D.A. and Evans, J.P. and Campbell, M. and McCombe, K. and Phillipou, A.N. and Gordon, L.J. and Jones, E.J. and Riching, K. and Mahmood, M. and Messenger, C. and Carver, C.E. and Gatfield, K.M. and Craggs, P.D., Erratum: Development of an intracellular quantitative assay to measure compound binding kinetics (Cell Chemical Biology (2022) 29(2) (287â"299.e8), (S2451945621003585), (10.1016/j.chembiol.2021.07.018)), Cell Chemical Biology, 2023, p1692
Oâ Callaghan, J. and Delaney, C. and Oâ Connor, M. and van Batenburg-Sherwood, J. and Schicht, M. and LÃŒtjen-Drecoll, E. and Hudson, N. and Dhubhghaill, S.N. and Humphries, P. and Stanley, C. and Keravala, A. and Chalberg, T. and Lawrence, M.S. and Campbell, M., Matrix metalloproteinase-3 (MMP-3)â"mediated gene therapy for glaucoma, Science Advances, 9, (16), 2023
Hashimoto Y, Greene C, Munnich A, Campbell M, The CLDN5 gene at the blood-brain barrier in health and disease., Fluids and barriers of the CNS, 2023
Oâ Riordan, M.M. and Cahill, M.T. and Campbell, M. and Kearney, H., Evaluation of Inflammation in the Peripheral Multiple Sclerosis Retina Using Ultra-Widefield Optical Coherence Tomography: A Pilot Study, Ophthalmic Surgery Lasers and Imaging Retina, 54, (10), 2023, p586-588
Oâ Riordan, M. and Hudson, N. and Oâ Callaghan, J. and Campbell, M. and Cahill, M., Near-Complete Drusen Resolution With Brolucizumab: A Mechanism for Proinflammatory Mediated Drusen Clearance?, Ophthalmic Surgery Lasers and Imaging Retina, 54, (6), 2023, p371-374
Desguerre, I. and Aubart, M. and Hashimoto, Y. and Poirier, K. and Kaminska, A. and Alison, M. and Boddaert, N. and Munnich, A. and Campbell, M., Reply: De novo mutations in CLDN5: alternating hemiplegia of childhood or not?, Brain, 146, (8), 2023, pE59-E60
Greene, C. and Campbell, M., Immunohistochemical Analysis of Tight Junction Proteins, Methods in Molecular Biology, 2492, 2022, p307-314
Hashimoto, Y. and Poirier, K. and Boddaert, N. and Hubert, L. and Aubart, M. and Kaminska, A. and Alison, M. and Desguerre, I. and Munnich, A. and Campbell, M., Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia, Brain : a journal of neurology, 145, (10), 2022, p3374-3382
Boyce, M. and Xin, Y. and Chowdhury, O. and Shang, P. and Liu, H. and Koontz, V. and Strizhakova, A. and Nemani, M. and Hose, S. and Zigler, J.S. and Campbell, M. and Sinha, D. and Handa, J.T. and Kaarniranta, K. and Qian, J. and Ghosh, S., Microgliaâ"Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model, Cells, 11, (22), 2022
Dion-Albert, L. and Cadoret, A. and Doney, E. and Kaufmann, F.N. and Dudek, K.A. and Daigle, B. and Parise, L.F. and Cathomas, F. and Samba, N. and Hudson, N. and Lebel, M. and Aardema, F. and Ait Bentaleb, L. and Beauchamp, J. and Bendahmane, H. and Benoit, E. and Bergeron, L. and Bertone, A. and Bertrand, N. and Berube, F.-A. and Blanchet, P. and Boissonneault, J. and Bolduc, C.J. and Bonin, J.-P. and Borgeat, F. and Boyer, R. and Breault, C. and Breton, J.-J. and Briand, C. and Brodeur, J. and Brule, K. and Brunet, L. and Carriere, S. and Chartrand, C. and Chenard-Soucy, R. and Chevrette, T. and Cloutier, E. and Cloutier, R. and Cormier, H. and Cote, G. and Cyr, J. and David, P. and De Benedictis, L. and Delisle, M.-C. and Deschenes, P. and Desjardins, C.D. and Desmarais, G. and Dubreucq, J.-L. and Dumont, M. and Dumais, A. and Ethier, G. and Feltrin, C. and Felx, A. and Findlay, H. and Fortier, L. and Fortin, D. and Fortin, L. and Francois, N. and Gagne, V. and Gagnon, M.-P. and Gignac-Hens, M.-C. and Giguere, C.-E. and Godbout, R. and Grou, C. and Guay, S. and Guillem, F. and Hachimi-Idrissi, N. and Herry, C. and Hodgins, S. and Homayoun, S. and Jemel, B. and Joyal, C. and Kouassi, E. and Labelle, R. and Lafortune, D. and Lahaie, M. and Lahlafi, S. and Lalonde, P. and Landry, P. and Lapaige, V. and Larocque, G. and Larue, C. and Lavoie, M. and Leclerc, J.-J. and Lecomte, T. and Lecours, C. and Leduc, L. and Lelan, M.-F. and Lemieux, A. and Lesage, A. and Letarte, A. and Lepage, J. and Levesque, A. and Lipp, O. and Luck, D. and Lupien, S. and Lusignan, F.-A. and Lusignan, R. and Luyet, A.J. and Lynhiavu, A. and Melun, J.-P. and Morin, C. and Nicole, L. and Noel, F. and Normandeau, L. and Oâ Connor, K. and Ouellette, C. and Parent, V. and Parizeau, M.-H. and Pelletier, J.-F. and Pelletier, J. and Pelletier, M. and Plusquellec, P. and Poirier, D. and Potvin, S. and Prevost, G. and Prevost, M.-J. and Racicot, P. and Racine-Gagne, M.-F. and Renaud, P. and Ricard, N. and Rivet, S. and Rolland, M. and Sasseville, M. and Safadi, G. and Smith, S. and Smolla, N. and Stip, E. and Teitelbaum, J. and Thibault, A. and Thibault, L. and Thibault, S. and Thomas, F. and Todorov, C. and Tourjman, V. and Tranulis, C. and Trudeau, S. and Trudel, G. and Vacri, N. and Valiquette, L. and Vanier, C. and Villeneuve, K. and Villeneuve, M. and Vincent, P. and Wolfe, M. and Xiong, L. and Zizzi, A. and Campbell, M. and Turecki, G. and Mechawar, N. and Menard, C., Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue, Nature Communications, 13, (1), 2022
Greene, C. and Hanley, N. and Reschke, C.R. and Reddy, A. and MÀe, M.A. and Connolly, R. and Behan, C. and Oâ Keeffe, E. and Bolger, I. and Hudson, N. and Delaney, C. and Farrell, M.A. and Oâ Brien, D.F. and Cryan, J. and Brett, F.M. and Beausang, A. and Betsholtz, C. and Henshall, D.C. and Doherty, C.P. and Campbell, M., Microvascular stabilization via blood-brain barrier regulation prevents seizure activity, Nature Communications, 13, (1), 2022
Lay, C.S. and Thomas, D.A. and Evans, J.P. and Campbell, M. and McCombe, K. and Phillipou, A.N. and Gordon, L.J. and Jones, E.J. and Riching, K. and Mahmood, M. and Messenger, C. and Carver, C.E. and Gatfield, K.M. and Craggs, P.D., Development of an intracellular quantitative assay to measure compound binding kinetics, Cell Chemical Biology, 29, (2), 2022, p287-299.e8
Amoo, M. and O'Halloran, P.J. and Henry, J. and Ben Husien, M. and Brennan, P. and Campbell, M. and Caird, J. and Curley, G.F., Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations, Journal of Neurotrauma, 39, (1-2), 2022, p20-34
Ozaki, E. and Delaney, C. and Campbell, M. and Doyle, S.L., Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration, Experimental Eye Research, 217, (108953), 2022
Chang, J.-H. and Greene, C. and Frudd, K. and Araujo dos Santos, L. and Futter, C. and Nichols, B.J. and Campbell, M. and Turowski, P., Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier, Cell Reports Medicine, 3, (1), 2022
Gibbons, L. and Ozaki, E. and Greene, C. and Trappe, A. and Carty, M. and Coppinger, J.A. and Bowie, A.G. and Campbell, M. and Doyle, S.L., SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration, Frontiers in Neuroscience, 16, (852114), 2022
Cassidy, P.S. and Kelly, R.A. and Reina-Torres, E. and Sherwood, J.M. and Humphries, M.M. and Kiang, A.-S. and Farrar, G.J. and O'Brien, C. and Campbell, M. and Stamer, W.D. and Overby, D.R. and Humphries, P. and O'Callaghan, J., siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model, Molecular Therapy - Methods and Clinical Development, 20, 2021, p86-94
Scott, L.M. and Vincent, E.E. and Hudson, N. and Neal, C. and Jones, N. and Lavelle, E.C. and Campbell, M. and Halestrap, A.P. and Dick, A.D. and Theodoropoulou, S., Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors, JCI Insight, 6, (8), 2021
Amoo, Michael and Henry, Jack and O'Halloran, Philip J and Brennan, Paul and Husien, Mohammed Ben and Campbell, Matthew and Caird, John and Javadpour, Mohsen and Curley, Gerard F, S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy, Neurosurgical review, 2021
Li, Xiaoqing and Vemireddy, Vamsidhara and Cai, Qi and Xiong, Hejian and Kang, Peiyuan and Li, Xiuying and Giannotta, Monica and Hayenga, Heather N and Pan, Edward and Sirsi, Shashank R and Mateo, Celine and Kleinfeld, David and Greene, Chris and Campbell, Matthew and Dejana, Elisabetta and Bachoo, Robert and Qin, Zhenpeng, Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles, Nano letters, 21, (22), 2021, p9805â"9815
Reschke, C.R. and Silva, L.F.A. and Vangoor, V.R. and Rosso, M. and David, B. and Cavanagh, B.L. and Connolly, N.M.C. and Brennan, G.P. and Sanz-Rodriguez, A. and Mooney, C. and Batool, A. and Greene, C. and Brennan, M. and Conroy, R.M. and RÃŒber, T. and Prehn, J.H.M. and Campbell, M. and Pasterkamp, R.J. and Henshall, D.C., Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy, Molecular Therapy, 29, (6), 2021, p2041-2052
O'Leary, Fionn and Campbell, Matthew, The blood-retina barrier in health and disease, The FEBS journal, 2021
Harford, D.A. and Delaney, C. and O'Callaghan, J. and Hudson, N. and Connolly, R. and Doyle, S. and Farrell, M. and Doherty, C.P. and Cahill, M. and Campbell, M., Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo- Drusen?, Ophthalmic Surgery Lasers and Imaging Retina, 52, (12), 2021, p666-671
Delaney, C. and Farrell, M. and Doherty, C.P. and Brennan, K. and Oâ Keeffe, E. and Greene, C. and Byrne, K. and Kelly, E. and Birmingham, N. and Hickey, P. and Cronin, S. and Savvides, S.N. and Doyle, S.L. and Campbell, M., Attenuated CSF-1R signalling drives cerebrovascular pathology, EMBO Molecular Medicine, 13, (2), 2021
Hudson, Natalie and Campbell, Matthew, Tight Junctions of the Neurovascular Unit, Frontiers in molecular neuroscience, 14, 2021, p752781
Kelly, Ruth A and Perkumas, Kristin M and Campbell, Matthew and Farrar, G Jane and Stamer, W Daniel and Humphries, Pete and O'Callaghan, Jeffrey and O'Brien, Colm J, Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma, International journal of molecular sciences, 22, (17), 2021
Goncalves, Andreia and Dreffs, Alyssa and Lin, Cheng-Mao and Sheskey, Sarah and Hudson, Natalie and Keil, Jason and Campbell, Matthew and Antonetti, David A, Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes, Diabetes, 70, (7), 2021, p1549â"1560
Amoo, M. and Henry, J. and Pender, N. and Brennan, P. and Campbell, M. and Javadpour, M., Blood-brain barrier permeability imaging as a predictor for delayed cerebral ischaemia following subarachnoid haemorrhage. A narrative review, Acta Neurochirurgica, 163, (5), 2021, p1457-1467
Hashimoto, Yosuke and Campbell, Matthew and Tachibana, Keisuke and Okada, Yoshiaki and Kondoh, Masuo, Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier, Biological & pharmaceutical bulletin, 44, (10), 2021, p1380â"1390
Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A., Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction, Brain, 2021
Naylor, A. and Hopkins, A. and Hudson, N. and Campbell, M., Tight junctions of the outer blood retina barrier, International Journal of Molecular Sciences, 21, (1), 2020
Ozaki, Ema, Gibbons, Luke, Neto, Nuno GB, Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew and Doyle, Sarah L, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020
Kiang, A.-S. and Kenna, P.F. and Humphries, M.M. and Ozaki, E. and Koenekoop, R.K. and Campbell, M. and Jane Farrar, G. and Humphries, P., Properties and therapeutic implications of an enigmatic d477g rpe65 variant associated with autosomal dominant retinitis pigmentosa, Genes, 11, (12), 2020, p1-21
Hashimoto, Y. and Campbell, M., Tight junction modulation at the blood-brain barrier: Current and future perspectives, Biochimica et Biophysica Acta - Biomembranes, 1862, (9), 2020
Laksari K, Fanton M, Wu LC, Nguyen TH, Kurt M, Giordano C, Kelly E, O'Keeffe E, Wallace E, Doherty C, Campbell M, Tiernan S, Grant G, Ruan J, dummy-AUTHOR_name, Camarillo DB, Multi-Directional Dynamic Model for Traumatic Brain Injury Detection., Journal of neurotrauma, 2020
Kenna, P.F. and Humphries, M.M. and Kiang, A.-S. and Brabet, P. and Guillou, L. and Ozaki, E. and Campbell, M. and Jane Farrar, G. and Koenekoop, R. and Humphries, P., Advanced late-onset retinitis pigmentosa with dominant-acting D477G RPE65 mutation is responsive to oral synthetic retinoid therapy, BMJ Open Ophthalmology, 5, (1), 2020
Tiernan S, Meagher A, O'Sullivan D, O'Keeffe E, Kelly E, Wallace E, Doherty CP, Campbell M, Liu Y, Domel AG, Concussion and the severity of head impacts in mixed martial arts., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 234, 2020, 1472 - 1483
Hudson, N. and Cahill, M. and Campbell, M., Inner blood-retina barrier involvement in dry age-related macular degeneration (AMD) pathology, Neural Regeneration Research, 15, (9), 2020, p1656-1657
Greene, C. and Hanley, N. and Campbell, M., Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders, Translational Psychiatry, 10, (1), 2020
Veksler, R. and Vazana, U. and Serlin, Y. and Prager, O. and Ofer, J. and Shemen, N. and Fisher, A.M. and Minaeva, O. and Hua, N. and Saar-Ashkenazy, R. and Benou, I. and Riklin-Raviv, T. and Parker, E. and Mumby, G. and Kamintsky, L. and Beyea, S. and Bowen, C.V. and Shelef, I. and O'Keeffe, E. and Campbell, M. and Kaufer, D. and Goldstein, L.E. and Friedman, A., Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players, Brain, 143, (6), 2020, p1826-1842
O'Keeffe, E. and Kelly, E. and Liu, Y. and Giordano, C. and Wallace, E. and Hynes, M. and Tiernan, S. and Meagher, A. and Greene, C. and Hughes, S. and Burke, T. and Kealy, J. and Doyle, N. and Hay, A. and Farrell, M. and Grant, G.A. and Friedman, A. and Veksler, R. and Molloy, M.G. and Meaney, J.F. and Pender, N. and Camarillo, D. and Doherty, C.P. and Campbell, M., Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury, Journal of neurotrauma, 37, (2), 2020, p347-356
Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL., Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration., Cell reports, 30, (7), 2020, p2209-2224.e5
Greene, C. and Campbell, M. and Janigro, D., Fundamentals of Brain-Barrier Anatomy and Global Functions, 2019, 3-20pp
O'Connor, C. and Ramanath, N. and Campbell, M., Pharmacokinetics of Systemic Drug Delivery, 2019, 39-56pp
Farrell, M. and Aherne, S. and O'Riordan, S. and O'Keeffe, E. and Greene, C. and Campbell, M., Blood-brain barrier dysfunction in a boxer with chronic traumatic encephalopathy and schizophrenia, Clinical Neuropathology, 38, (2), 2019, p51-58
Hudson, N. and Celkova, L. and Hopkins, A. and Greene, C. and Storti, F. and Ozaki, E. and Fahey, E. and Theodoropoulou, S. and Kenna, P.F. and Humphries, M.M. and Curtis, A.M. and Demmons, E. and Browne, A. and Liddie, S. and Lawrence, M.S. and Grimm, C. and Cahill, M.T. and Humphries, P. and Doyle, S.L. and Campbell, M., Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy, JCI Insight, 4, (15), 2019, p130273-
Crosbie, D.E. and Keaney, J. and Tam, L.C.S. and Daniel Stamer, W. and Campbell, M. and Humphries, P., Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI, Magnetic Resonance Imaging, 59, 2019, p10-16
Campbell, M. and Doyle, S.L., Current perspectives on established and novel therapies for pathological neovascularization in retinal disease, Biochemical Pharmacology, 164, 2019, p321-325
Doherty, C.P., O'Keeffe. E., Keaney, J., Lawlor, B.A., Coen, R.F., Farrell, M., Campbell, M., Neuropolypathology as a result of severe traumatic brain injury? , Clinical Neuropathology, 38, (1), 2019, p14 - 22
Augustine, J. and Pavlou, S. and Ali, I. and Harkin, K. and Ozaki, E. and Campbell, M. and Stitt, A.W. and Xu, H. and Chen, M., IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment, Journal of Neuroinflammation, 16, (1), 2019
Hudson, N. and Campbell, M., Inner Blood-Retinal Barrier Regulation in Retinopathies, Advances in Experimental Medicine and Biology, 1185, 2019, p329-333
Greene, C. and Hanley, N. and Campbell, M., Claudin-5: Gatekeeper of neurological function, Fluids and Barriers of the CNS, 16, (1), 2019
Oâ Callaghan, J. and Campbell, M. and Humphries, P., Intracameral delivery of AAV to corneal endothelium for expression of secretory proteins, Methods in Molecular Biology, 1950, 2019, p263-270
Campbell, M. and Cassidy, P.S. and O'Callaghan, J. and Crosbie, D.E. and Humphries, P., Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension, Progress in Retinal and Eye Research, 62, 2018, p120-133
Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbroucke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Correction: Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017 [Fluids Barriers CNS 14, (2017) (31)] DOI: 10.1186/s12987-017-0079-9, Fluids and Barriers of the CNS, 15, (1), 2018, p3-
Alamillo-Ferrer, C. and Curle, J.M. and Davidson, S.C. and Lucas, S.C.C. and Atkinson, S.J. and Campbell, M. and Kennedy, A.R. and Tomkinson, N.C.O., Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines, Journal of Organic Chemistry, 83, (12), 2018, p6728-6740
Kealy, J. and Greene, C. and Campbell, M., Blood-brain barrier regulation in psychiatric disorders, Neuroscience Letters, 2018
Delaney, C. and Campbell, M., The blood brain barrier: Insights from development and ageing, Tissue Barriers, 5, (4), 2017, pe1373897 -
Theodoropoulou S, Copland D.A, Liu J, Wu J, Gardner P.J, Ozaki E, Doyle S.L, Campbell M, Dick A.D, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye, Journal of Pathology, 241, (1), 2017, p45 - 56
Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbrouke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017, Fluids and Barriers of the CNS, 14, (1), 2017, p31-
Tam L.C.S, Reina-Torres E, Sherwood J.M, Cassidy P.S, Crosbie D.E, LÃ"tjen-Drecoll E, FlÃ"gel-Koch C, Perkumas K, Humphries M.M, Kiang A.-S, O'Callaghan J, Callanan J.J, Read A.T, Ethier C.R, O'Brien C, Lawrence M, Campbell M, Stamer W.D, Overby D.R, Humphries P, Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia, Scientific Reports, 7, 2017, p40717-
O'Callaghan, J. and Crosbie, D.E. and Cassidy, P.S. and Sherwood, J.M. and FlÃŒgel-Koch, C. and LÃŒtjen-Drecoll, E. and Humphries, M.M. and Reina-Torres, E. and Wallace, D. and Kiang, A.-S. and Campbell, M. and Stamer, W.D. and Overby, D.R. and O'Brien, C. and Tam, L.C.S. and Humphries, P., Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma, Human Molecular Genetics, 26, (7), 2017, p1230-1246
C Greene, J Kealy, M M Humphries, Y Gong, J Hou, N Hudson, L M Cassidy, R Martiniano, V Shashi, S R Hooper, G A Grant, P F Kenna, K Norris, C K Callaghan, M dN Islam, S M O'Mara, Z Najda, S G Campbell, J S Pachter, J Thomas, N M Williams, P Humphries, K C Murphy, M Campbell, Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia, Molecular Psychiatry, 2017
Shah T.M, Gupta S.M, Chatterjee P, Campbell M, Martins R.N, Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimerâ s disease, Molecular Psychiatry, 22, 2017, p353-363-
Menard, C. and Pfau, M.L. and Hodes, G.E. and Kana, V. and Wang, V.X. and Bouchard, S. and Takahashi, A. and Flanigan, M.E. and Aleyasin, H. and Leclair, K.B. and Janssen, W.G. and Labonté, B. and Parise, E.M. and Lorsch, Z.S. and Golden, S.A. and Heshmati, M. and Tamminga, C. and Turecki, G. and Campbell, M. and Fayad, Z.A. and Tang, C.Y. and Merad, M. and Russo, S.J., Social stress induces neurovascular pathology promoting depression, Nature Neuroscience, 20, (12), 2017, p1752-1760
Greene C, Campbell M, Tight junction modulation of the blood brain barrier: CNS delivery of small molecules, Tissue Barriers, 4, (1), 2016, pe1138017-
Oleszycka, E., Moran, H.B.T., Tynan, G.A., Hearnden, C.H., Coutts, G., Campbell, M., Allan, S.M., Scott, C.J. and Lavelle, E.C. , IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination. , FEBS Journal, 283, (1), 2016, p9 - 24
O'Keeffe E, Campbell M, Modulating the paracellular pathway at the bloodâ"brain barrier: current and future approaches for drug delivery to the CNS, Drug Discovery Today: Technologies, 20, 2016, p35 - 39
5. S Theodoropoulou, S Doyle, D Copland, J Liu, J Wu, M Campbell, A Dick, Interleukin 33/ST2 signaling regulates inflammatory response in choroidal stroma and ocular angiogenesis: implications for age‐related macular degeneration., Acta Ophthalmologica, 93, (S255), 2016
Doherty C.P, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries M.M, Molloy M.G, Meaney J.F, Farrell M, Campbell M, Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy, Journal of Neuropathology and Experimental Neurology, 75, (7), 2016, p656 - 662
Keaney J, Campbell M, The dynamic blood-brain barrier, FEBS Journal, 282, (21), 2015, p4067 - 4079
Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203
Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M, IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates., Invest Ophthalmol Vis Sci, 56, (9), 2015, p5424-30
Doyle SL, López FJ, Humphries P, Adamson P, Campbell M, Author Response: The Role of IL-18 in the Treatment of AMD., Invest Ophthalmol Vis Sci, 56, (3), 2015, p8237-8
Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M., Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier., Science Advances, 1, (8), 2015, p10.1126/sci adv.1500472
Ozaki E, Campbell M, Doyle S.L, Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives, Journal of Inflammation Research, 8, 2015, p15 - 27
Abrahams J.L, Packer N.H, Campbell M.P, Relative quantitation of multi-antennary N-glycan classes: Combining PGC-LC-ESI-MS with exoglycosidase digestion, Analyst, 140, (16), 2015, p5444 - 5449
Campbell M.P, Royle L, Rudd P.M, Glycobase and autoGU: Resources for interpreting HPLC-glycan data, Glycoinformatics: Methods in Molecular Biology, 1273, 2015, 17-28
Ranzinger R, Aoki-Kinoshita K.F, Campbell M.P, Kawano S, Lütteke T, Okuda S, Shinmachi D, Shikanai T, Sawaki H, Toukach P, Matsubara M, Yamada I, Narimatsu H, GlycoRDF: An ontology to standardize glycomics data in RDF, Bioinformatics, 31, (6), 2015, p919 - 925
Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050
York W.S, Agravat S, Aoki-Kinoshita K.F, Mcbride R, Campbell M.P, Costello C.E, Dell A, Feizi T, Haslam S.M, Karlsson N, Khoo K.-H, Kolarich D, Liu Y, Novotny M, Packer N.H, Paulson J.C, Rapp E, Ranzinger R, Rudd P.M, Smith D.F, Struwe W.B, Tiemeyer M, Wells L, Zaia J, Kettner C, MIRAGE: The minimum information required for a glycomics experiment, Glycobiology, 24, (5), 2014, p402 - 406
Ozaki, E., Campbell, M., Kiang, A.S., (...), Doyle, S.L., Humphries, P. , Inflammation in age-related macular degeneration., Advances in experimental medicine and biology, 801, 2014, p229-235
Campbell, M., Doyle, S., Humphries, P. , IL-18: A new player in immunotherapy for age-related macular degeneration?, Expert Review of Clinical Immunology, 10, (10), 2014, p1273-1275
Doyle, S.L., Adamson, P., López, F.J., Humphries, P., Campbell, M. , Interleukin-18 bioactivity and dose: Data interpretation at a crossroads, Investigative Ophthalmology and Visual Science, 55, (12), 2014, p8349
Hudson N, Powner M.B, Sarker M.H, Burgoyne T, Campbell M, Ockrim Z.K, Martinelli R, Futter C.E, Grant M.A, Fraser P.A, Shima D.T, Greenwood J, Turowski P, Differential apicobasal VEGF signaling at vascular blood-neural barriers, Developmental Cell, 30, (5), 2014, p541 - 552
Kiang, A.S., Humphries, M.M., Campbell, M., Humphries, P. , Antioxidant therapy for retinal disease., Advances in experimental medicine and biology, 801, 2014, p783-789
7. S Doyle, PS Adamson, FJ Lopez, P Humphries, M Campbell , IL-18 promotes wound healing and has anti-angiogenic properties in the eye., Investigative Ophthalmology & Visual Science, ARVO, Orlando, 56 (7), , 2014, pp2462-2462
Campbell, M., Doyle, S.L., Ozaki, E., (...), Humphries, M.M., Humphries, P. , An overview of the involvement of interleukin-18 in degenerative retinopathies., Advances in experimental medicine and biology, 801, 2014, p409-415
Doyle S.L, Adamson P, López F.J, Humphries P, Campbell M, Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration, Nature Medicine, 20, (12), 2014, p1376 - 1377
Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-
Nguyen, A.T., Campbell, M., Kiang, A.S., Humphries, M.M., Humphries, P. , Current therapeutic strategies for P23H RHO-linked RP., Advances in experimental medicine and biology, 801, 2014, p471-476
Rouine, J, Gobbo, OL, Campbell, M, Gigliucci, V, Ogden, I, Smith, KM, Duffy, P, Behan, B, Byrne, D, Kelly, ME, Blau, CW, Kerskens, CM, Harkin, A, MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI, BRITISH JOURNAL OF PHARMACOLOGY, 169, (5), 2013, p974-987
9. M Campbell, E Ozaki, MM Humphries, PS Adamson, P Humphries, NLRP3 independent mechanisms of RPE cell death, Investigative Ophthalmology & Visual Science, ARVO, Seattle, 55 (13), 2013, pp1318-1318
Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Jane Farrar G, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy., European journal of human genetics : EJHG, 21, (1), 2013, p62-8
Barrier modulation in drug delivery to the retina. in, Retinal Degeneration, 2013, pp371-80 , [Campbell M, Humphries MM, Humphries P]
Humphries P, Humphries MM, Tam LC, Farrar GJ, Kenna PF, Campbell M, Kiang A-S. , Hereditary retinopathies: progress in development of genetic and molecular therapies., SpringerBriefs in Genetics, Springer NY. , 2013
Campbell M, Doyle SL, An eye on the future of inflammasomes and drug development in AMD., Journal of molecular medicine (Berlin, Germany), 91, (9), 2013, p1059-70
Campbell*, M, Doyle*, SL, Ozaki, E, Salomon, RG, Mori, A, Kenna, PF, Kiang, AS, Humphries, MM, Lavelle, EC, O'Neill, LAJ, Hollyfield, JG, and Humphries, P, NLRP3 plays a protective role during the development of age related macular degeneration through the induction of IL-18 by drusen components., Nature Medicine, 18, (5), 2012, p791 - 798
Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., (...), Zuckerbraun, B., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, (4), 2012, p445-544
Tam LC, Kiang AS, Campbell M, Keaney J, Farrar GJ, Humphries MM, Kenna PF, Humphries P, Protein misfolding and potential therapeutic treatments in inherited retinopathies., Advances in experimental medicine and biology, 723, 2012, p567-72
Humphries MM, Kenna PF, Campbell M, Tam LC, Nguyen AT, Farrar GJ, Botto M, Kiang AS, Humphries P, C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa., European journal of human genetics : EJHG, 20, (1), 2012, p64-8
Nguyen AT, Campbell M, Kenna PF, Kiang AS, Tam L, Humphries MM, Humphries P, Calpain and photoreceptor apoptosis., Advances in experimental medicine and biology, 723, 2012, p547-52
Campbell M, Humphries P, The blood-retina barrier: tight junctions and barrier modulation., Advances in experimental medicine and biology, 763, 2012, p70-84
Hanrahan, F, Campbell, M, Nguyen, AT, Suzuki, M, Kiang, AS, Tam, LC, Gobbo, OL, Dhubhghaill, SN, Humphries, MM, Kenna, PF, Humphries, P, LaVail, MM, Ash, JD, Anderson, RE, Hollyfield, JG, Grimm, C, On Further Development of Barrier Modulation as a Technique for Systemic Ocular Drug Delivery, RETINAL DEGENERATIVE DISEASES, 723, 2012, p155-159
Campbell M, Hanrahan F, Gobbo OL, Kelly ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW, Kerskens CM, Cahalan SD, Callanan JJ, Wallace E, Grant GA, Doherty CP, Humphries P, Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury., Nature communications, 3, 2012, p849
Bowne, S.J., Humphries, M.M., Sullivan, L.S., Kenna, P.F., Tam, L.C.S., Kiang, A.S., Campbell, M., (...), Humphries, P. , Erratum: A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (European Journal of Human Genetics (2011) 19 (1074-1081) DOI: 10.1038/ejhg.2011.86), 2011, - 1109
Dagdan E, Morris D, Campbell M, Hill M, Rothermundt M, Kastner F, Hofoff C, Von Eiff, Krakowitzky P, Gill M, McKeon P, Roche S, Functional Assessment of a Promoter Polymorphism in S100B, a putative Risk Variant for Bipolar Disorder, Neuropsychiatric Genetics, 156, (6), 2011, p691 - 699
Bowne, SJ, Humphries, MM, Sullivan, LS, Kenna, PF, Tam, LCS, Kiang, AS, Campbell, M, Weinstock, GM, Koboldt, DC, Ding, L, Fulton, RS, Sodergren, EJ, Allman, D, Millington-Ward, S, Palfi, A, McKee, A, Blanton, SH, Slifer, S, Konidari, I, Farrar, GJ, Daiger, SP, Humphries, P, A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement, EUROPEAN JOURNAL OF HUMAN GENETICS, 19, (10), 2011, p1074-1081
Campbell M, Humphries MM, Nguyen ATH, Gobbo OL, Tam LCS, Suzuki M, Hanrahan F, Ozaki E, Farrar G-J, Kiang A-S, Kenna PF, Humphries P. , Systemic low-molecular weight drug delivery to pre-selected neuronal regions, EMBO Molecular Medicine, 3, (4), 2011, p235-245
Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE, Wnt signaling mediates pathological vascular growth in proliferative retinopathy., Circulation, 124, (17), 2011, p1871-81
Keaney J, Campbell M, Humphries P, From RNA interference technology to effective therapy: how far have we come and how far to go?, Therapeutic delivery, 2, (11), 2011, p1395-406
Campbell M, Humphries P, Size-selective and in vitro assessment of inner blood retina barrier permeability., Methods in molecular biology (Clifton, N.J.), 763, 2011, p355-67
Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P, Protection of photoreceptors in a mouse model of RP10., Advances in Experimental Medicine and Biology, 664, (Part 5), 2010, p559-65
Campbell M, Nguyen AT, Kiang AS, Tam L, Kenna PF, Dhubhghaill SN, Humphries M, Farrar GJ, Humphries P, Reversible and size-selective opening of the inner Blood-Retina barrier: a novel therapeutic strategy., Advances in Experimental Medicine and Biology, 664, (Part 3), 2010, p301-8
Campbell M, Ozaki E, Humphries P, Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach., Expert Opinion on Drug Delivery, 7, (7), 2010, p859-69
Ni Dhubhghaill SS, Cahill MT, Campbell M, Cassidy L, Humphries MM, Humphries P, The pathophysiology of cigarette smoking and age-related macular degeneration., Advances in Experimental Medicine and Biology, 664, (Part 4), 2010, p437-46
Lawrence C. S. Tam, Anna-Sophia Kiang, Matthew Campbell, James Keaney, G. Jane Farrar, Marian M. Humphries, Paul F. Kenna and Pete Humphries, Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Human Molecular Genetics, 19, (22), 2010, p4421-4436
Hanrahan, F., Humphries, P., Campbell, M., RNAi-mediated barrier modulation: Synergies of the brain and eye, Therapeutic Delivery , 1, (4), 2010, p587-594
Matthew Campbell, Anh T. H. Nguyen, Anna-Sophia Kiang, Lawrence C. S. Tam, Oliviero L. Gobbo, Christian Kerskens, Sorcha Ni Dhubhghaill, Marian M. Humphries, G.-Jane Farrar, Paul F. Kenna and Peter Humphries, An experimental platform for systemic drug delivery to the retina, Proceedings of the National Academy of Sciences of the United States, 106, (42), 2009, p17817 - 17822
O. Gobbo, M. Campbell, A.Kiang, P. Kenna, C. Kerskens, G. J. Farrar, P. Humphries, RNAi-MEDIATED REVERSIBLE OPENING OF THE BLOOD-BRAIN AND BLOODRETINA BARRIER, MRI Satellite Symposium, 2009
Campbell, M, Kiang, AS, Kenna, PF, Kerskens, C, Blau, C, O'Dwyer, L, Tivnan, A, Kelly, JA, Brankin, B, Farrar, GJ, Humphries, P, RNAi-mediated reversible opening of the blood-brain barrier., The Journal of Gene Medicine, 10, (8), 2008, p930 - 947
Tam, LC, Kiang, AS, Kennan, A, Kenna, PF, Chadderton, N, Ader, M, Palfi, A, Aherne, A, Ayuso, C, Campbell, M, Reynolds, A, McKee, A, Humphries, MM, Farrar, GJ, Humphries, P, Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)., Human Molecular Genetics, 17, (14), 2008, p2084-2100
Campbell, M, Humphries, M, Kenna, P, Humphries, P, Brankin, B, Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouse., Experimental Eye Research, 85, (5), 2007, p714-720
Campbell M, Humphries MM, Kennan A, Kenna PF, Humphries P and Brankin B., Aberrant Retinal Tight Junction and Adherens junction protein expression in an animal model of autosomal recessive retinitis pigmentosa: The Rho (-/-) mouse, Exp. Eye Res, 83, (3), 2006, p484 - 492
Non-Peer-Reviewed Publications
1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016
12. GA Grant, C Wilson, M Campbell, S Li, P Humphries, A Johnson, Reversible Opening of the Blood-brain Barrier by Targeted Suppression of Claudin 5 To Enhance Drug Delivery into Brain Tumors. , Annals of Neurology , 2012
10. C Doherty, E Wallace, M Campbell, P Humphries, Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury., Neurology 2012, SAINT JAMES HOSPITAL DUBLIN (IRELAND), 2012
Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179
Research Expertise
Projects
- Title
- Eye-D: Therapeutic target identification for degenerative eye disease
- Summary
- This project is focused on identifying the molecular cause of blindness including age related macular degeneration (AMD), glaucoma and inherited retinal diseases. It is an industry academic consortium and involves collaboration with Roche, Eli Lilly and Progressive Vision as well as a collaboration with the Irish charity Fighting Blindness Ireland.
- Funding Agency
- SFI
- Date From
- 1/11/2021
- Date To
- 31/10/2025
- Title
- Retina Rhythm:Investigating the role of the inner retina in age-related macular degeneration (AMD)
- Summary
- This is an ERC project focused on identifying the earliest causes of age related macular degeneration (AMD). The central hypothesis is that AMD is driven by a dysfunction of blood vessels in the inner retina and that regulating the integrity of these vessels may stabilise the condition.
- Funding Agency
- European Research Council
- Date From
- 1/7/2020
- Date To
- 30/6/2025
Recognition
Representations
Member of the scientific review committee of Moorfields Eye Charity, UK.
Editorial board member for Investigative Ophthalmology and Vision Science (IOVS)
Awards and Honours
Science Foundation Ireland, Young Researcher of the year
European Research Council Consolidator Award
Irish Research Council Laureate Award.
Association for Ocular Pharmacology and Therapeutics, National Eye Institute (NEI) award
Association for Research in Vision and Ophthalmology, NEI travel Award
Genentech/ARVO fellowship in recognition of my research on AMD
Science Foundation Ireland, President of Ireland Young Researcher Award (PIYRA)
"Pro-Retina" travel award for XVth International Symposium on Retinal Degenerations
Appointed Senior Research Fellow, TCD
Roche Research Award, Smurfit Institute of Genetics
Fighting Blindness Ireland Research Scholarship
Fellow of the Szeged Academy of Science, Hungary
Fellow of TCD
Memberships
Associate Editor, Fluids and Barriers of the CNS
Member of the Executive committee of FutureNeuro
Member of the SAB of the Alternating Hemiplegia of Childhood (AHCF) charity
Member of the SAB of the Moorfields Hospital Charity
Vice Chair, Sight Research UK, SAB
Associate Editor, IOVS
Member of International Society for Eye Research. 2010-present: International Brain Barriers Society (IBBS).