Professor Jeffrey O'Sullivan
Assistant Professor in Biological Sciene, Dental Science
Assistant Professor in Biological Sciene, Sch Office - Biochemistry & Immunology
Biography
Publications and Further Research Outputs
Peer-Reviewed Publications
O'Grady I, O'Sullivan J., Alcohol consumption modulates Candida albicans-induced oral carcinogenesis and progression., Journal of oral biosciences, 2023, pS1349-0079(23)00130-5
Anderson A, O'Sullivan J., The two faces of autophagy in oral squamous cell carcinoma, Archives of Oral Biology, 2022
Magnano S, Hannon Barroeta P, Duffy R, O'Sullivan J, Zisterer DM., Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species., Toxicology and applied pharmacology, 427, 2021, p115646
Ahmed WH, Boulet N, Briot A, Ryan BJ, Kinsella GK, O'Sullivan J, Les F, Mercader-Barceló J, Henehan GTM, Carpéné C., Novel Facet of an Old Dietary Molecule? Direct Influence of Caffeine on Glucose and Biogenic Amine Handling by Human Adipocytes., Molecules (Basel, Switzerland), 26, (13), 2021
Sinevici N, Harte N, O'Grady I, Xie Y, Min S, Hun Mok K, O'Sullivan J., The novel therapeutic potential of bovine "-lactalbumin made lethal to tumour cells and oleic acid in oral squamous cell carcinoma., European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2020
Haj Ahmed W, Peiro C, Fontaine J, Ryan BJ, Kinsella GK, O'Sullivan J, Grolleau JL, Henehan GTM, Carpéné C., Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue., Medicines (Basel), 7, (4), 2020
Ibrahim O, O'Sullivan J., Iron chelators in cancer therapy., Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 33, (4-5), 2020, p201-215
O'Grady I, Anderson A, O'Sullivan J., The interplay of the oral microbiome and alcohol consumption in oral squamous cell carcinomas., Oral oncology, 110, 2020, p105011
Bennett JH, Beeley JA, Anderson P, Belfield L, Brand HS, Didilescu AC, Dymock D, Guven Y, Hector MP, Holbrook P, Jayasinghe JAP, O'Sullivan J, Riggio M, Roger-Leroi V, Scheven B, Sloan AJ, Vandamme K, Manzanares MC., A core curriculum in the biological and biomedical sciences for dentistry., European journal of dental education : official journal of the Association for Dental Education in Europe, 24, (3), 2020, p433-441
A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Jeremy D. Osko, Giulia Chemi, Stefano Federico, Alessandro Grillo, Simone Brogi, Niamh H. McCabe, Richard C. Turkington, Ola Ibrahim, Jeffrey O'Sullivan, Stefania Lamponi, Magda Ghanim, Vincent P. Kelly, Daniela Zisterer, Rebecca Amet, Patricia Hannon, Francesca Vanni, Cristina Ulivieri, Daniel Herp, Federica Sarno, Antonella Di Costanzo, Fulvio Saccoccia, Giovina Ruberti, Manfred Jung, Lucia Altucci, Sandra Gemma, Stefania Butini, David W. Christianson, and Giuseppe Campiani, Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, 2 Synthesis, Structural Analysis, and Biological Evaluation , ACS Medicinal Chemistry Letters, 2020
Carvalho LFCS, Dos Santos L, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto LPM, Martin AA, Lyng FM, Byrne HJ., Can ethanol affect the cell structure? A dynamic molecular and Raman spectroscopy study., Photodiagnosis and photodynamic therapy, 30, 2020, p101675
Sinevici N, Mittermayer S, Davey GP, Bones J, O'Sullivan J, Salivary N-glycosyalation as a biomarker of Oral Cancer: A pilot study., Glycobiology, 2019
Shanahan, P. and O'Sullivan, J. and Tipton, K.F. and Kinsella, G.K. and Ryan, B.J. and Henehan, G.T.M., Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase, Journal of Food Biochemistry, 2019, pe12697-
Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma,Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Maria Rosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Sullivan, Lucia Morbidelli, Roberta Spaccapelo, Cosima Baldari, Stefania Butini, Ettore Novellino, Giuseppe Campiani, Lucia Altucci, Michel Steinmetz, Simone Brogi, Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, European Journal of Medicinal Chemistry, 2019, p290-320
Carvalho LFCS, Bonnier F, Tellez C, Dos Santos L, O'Callaghan K, O'Sullivan J, Soares LES, Flint S, Martin AA, Lyng FM, Byrne HJ., Raman spectroscopic analysis of oral cells in the high wavenumber region., Experimental and molecular pathology, 103, (3), 2017, p255-262
Al Ghazal L, O'Sullivan J, Claffey N, Polyzois I, Comparison of two different techniques used for the maintenance ofperi-implant soft tissue health: a pilot randomized clinical trial., Acta Odontologica Scandinavica , 75, (7), 2017, p542-549
Sinevici N, O'sullivan J, Oral cancer: Deregulated molecular events and their use as biomarkers, Oral Oncology, 61, 2016, p12 - 18
Carvalho LF, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Byrne HJ, Lyng FM, Raman micro-spectroscopy for rapid screening of oral squamous cell carcinoma., Experimental and molecular pathology, 98, (3), 2015, p502-9
Carvalho L.F.C.S, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto L.P.M, Soto C.A.T, Dos Santos L, Martin A.A, Byrne H.J, Lyng F.M, Raman spectroscopic analysis of oral squamous cell carcinoma and oral dysplasia in the high-wavenumber region, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2015, 9531, 2015
O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54
Olivieri A, Tipton K, O'Sullivan J, Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine., Biochimica et biophysica acta, 1820, (4), 2012, p482-487
Olivieri A, Rico D, Khiari Z, Henehan G, O'Sullivan J, Tipton K, From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase., Journal of neural transmission (Vienna, Austria : 1996), 118, (7), 2011, p1079-1089
Aldo Olivieri, Jeff O'Sullivan, Luis Raimon Alvarez Fortuny, Itziar Larrauri Vives, Keith F. Tipton, Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions, BBA - Proteins and Proteomics, 1804, (4), 2010, p941-947
Olivieri A, O'Sullivan J, Fortuny LR, Vives IL, Tipton KF, Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions., Biochimica et biophysica acta, 1804, 2010, p941 - 947
Olivieri A, Davey G, O'Sullivan M I, Tipton K F, Boyce S, McDonald A G, O'Sullivan J(ed.), European Conference on Chemistry for Life Sciences, Poland, 2007, 2008, 51-57 p
Copper amine oxidases: structures, catalytic mechanisms and role in pathophysiology in, editor(s)Giovanni Floris Bruno Mondovi , Nomenclature and Potential Functions of the Mammalian Copper Amine Oxidases, London, Taylor & Francis Group, 2008, [Boyce S, Tipton KF, O'Sullivan M I, Davey G P, Motherway Gildea M, McDonald A G, Olivieri A, O'Sullivan J]
Andrew McDonald, Keith Tipton, Jeff O'Sullivan, Aldo Olivieri, Gavin Davey, Anne-marie Coonan and Wenhao Fu, Modelling the roles of MAO and SSAO in glucose transport, Journal of Neural Transmission, 114, (6), 2007, p783 - 786
Aldo Olivieri, Keith Tipton and Jeff O'Sullivan, L-Lysine as a recognition molecule for the VAP-1 function of SSAO, Journal of Neural Transmission, 6, (114), 2007, p747 - 749
Jeff O'Sullivan, Gavin Davey, Michael O'Sullivan and Keith F. Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, Journal of Neural Transmission, 6, (114), 2007, p751 - 756
O'Sullivan, J., O'Sullivan, M. I., Tipton, K.F., Davey, G., Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine, Journal of Neural Transmission, Suppl, (71), 2007, p105 - 112
O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF., Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do., Neurotoxicology, Jan 25, (1-2), 2004, p303 - 315
Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J, Monoamine oxidases: Certainties and uncertainties, Current Medicinal Chemistry, Aug 11, (15), 2004, p1965 - 1982
Monoamine oxidase (MAO):functions in the central nervous system in, editor(s)George Adelman And Barry H. Smith. , Encylopedia of Neuroscience 2004 , Elsevier, 2004, [Tipton KF, O'Sullivan J. Youdim MBH]
Tipton KF, O'Sullivan M, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme., Biochemical Society Transactions, Jun:31, (Pt. 3), 2003, p711 - 715
O'Sullivan J, O'Sullivan M, Tipton K F, Unzeta M, Hernandez M, Davey G, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses. , Biochemica et biophysica acta, Apr 11, (1647), 2003, p367 - 371
Non-Peer-Reviewed Publications
Magnano, S., O'Sullivan, J. and Zisterer, D.M., Pre-clinical evaluation of targeting autophagy for the treatment of Oral Squamous Cell Carcinoma , IADR Irish Divison, Belfast, November 2nd 2017, 2017
Research Expertise
Description
Oral Cancer; Oral inflammation; Amine Oxidases, Protein ScienceProjects
- Title
- The development of in-vitro models of alcohol induced oral carcinogenesis
- Funding Agency
- Dublin Dental University Hospital/ Trinity College Dublin
- Date From
- Oct 2010
- Title
- Cloning and charaterisation of dental pulp SSAO
- Title
- The role of dental pulp stem cells in neurotrophic support
- Title
- The influence of Periodontitis in Diabetes
Recognition
Representations
Irish Division IADR Council Member President 2018-19
ASEiD Council Member
Awards and Honours
Irish Society of Toxicology Scholarship
Memberships
European Association for Cancer Research
Biochemistry Society
International Association of Dental Research
Association of Basic Science Teachers in Dentistry
Institute of Physics (IoP)