Dr. Friedrich Wetterling

• Gobbo, O.L., Wetterling, F., Vaes, P., Teughels, S., Markos, F., Edge, D., Shortt, C. M., Crosbie-Staunton, K., Radomski, M.W., Volkov, Y., Prina-Mello, A, Biodistribution and pharmacokinetic studies of SPION using particle Electron Paramagnetic Resonance, MRI and ICP-MS, Nanomedicine (Lond.), 10, 2015, p1751 - 1760Journal Article, 2015, DOI , URL
• Tozzi L., Carballedo A., Wetterling F., McCarthy H., O'Keane V., Gill M., Morris D., Fahey C., Meaney J., Frodl T., Single Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression., Neuropsychopharmacology, 41, 2016, p487-497Journal Article, 2016
• Andreas Graessl, Anjuli Ruehle, Helmar Waiczies, Ana Resetar, Stefan H Hoffmann, Jan Rieger, Friedrich Wetterling, Lukas Winter, Armin M Nagel, Thoralf Niendorf, Sodium MRI of the human heart at 7.0 T: preliminary results, NMR in Biomedicine, 2015Journal Article, 2015, DOI
• Wetterling, F., McCarthy, H., Tozzi, L., Skokauskas, N., O'Doherty J. P., Mulligan, A., Meaney, J., Fagan, A. J., Gill, M., Frodl, T., Impaired Reward Processing in the Human Prefrontal Cortex Distinguishes Between Persistent and Remittent Attention Deficit Hyperactivity Disorder, HUMAN BRAIN MAPPING, 36, (1), 2015, p4648-4663Journal Article, 2015, DOI , URL
• Giblin, S., Meldrum D., McGroarty M., O'Brien S., Rand S., Smith S., Grogan K., Wetterling F., Bone length calibration can significantly improve the measurement accuracy of knee flexion angle when using a marker-less system to capture the motion of countermovement jump, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, 2016, p392-397Journal Article, 2016, TARA - Full Text
• Wetterling F, Sheridan WS, Testani JM, Borlaug BA, Fudim M, Damman K, Gray A, Gaines P, Poloczek M, Madden S, Tucker J, Buxo T, Gaul R, Corcoran L, Sweeney F, Burkhoff D., Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation., European journal of heart failure, 25, (5), 2023, p754-763Journal Article, 2023
• Ivey-Miranda JB, Wetterling F, Gaul R, Sheridan S, Asher JL, Rao VS, Maulion C, Mahoney D, Mebazaa A, Gray AP, Burkhoff D, Cowie MR, Cox ZL, Butler J, Fudim M, McDonald K, Damman K, Borlaug BA, Testani JM., Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone., European journal of heart failure, 24, (3), 2022, p455-462Journal Article, 2022
• Wetterling F, Chatzikonstantinou E, Tritschler L, Meairs S, Fatar M, Schad LR, Ansar S., Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging., BMC neuroscience, 17, (1), 2016, p82Journal Article, 2016
• Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S., Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging., Acta physiologica (Oxford, England), 223, (1), 2018, pe12985Journal Article, 2018
• Andrew Fagan, Friedrich Wetterling, Development of sodium-MRI for stroke and tumour investigations in rodents, IRISH JOURNAL OF MEDICAL SCIENCE, Faculty of Radiologists Royal College of Surgeons in Ireland, Dublin, 25-27 September 2008, edited by Irish Journal of Medical Science , 177, (Supplement 8), Springer, 2008, ppS271 - S271Conference Paper, 2008, URL , TARA - Full Text
• Friedrich Wetterling, Judith Kisubi, Eva Haardt, Simon Konstandin, Armin Nagel, Marc Fatar, Eva Neumaier-Probst, Lothar R. Schad, Quantitative 23Na-MRI: From Pre-Clinical to Clinical Practice, 41st annual meeting of the German Association for Medical Physics (DGMP), Freiburg, Germany, 41, 2010, pp1Conference Paper, 2010, URL , TARA - Full Text
• McCarthy H., Stanley J., Piech R., Wetterling F., Skokauskas N., Mulligan A., Donohoe G., Mullins D., Kelly J., Johnson K., Fagan A., Gill M., Meaney J., Frodl T., Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood, Journal of Attention Disorders, 22, (6), 2018, 561, p570Journal Article, 2018
• Weinberger O., Winter L., Dieringer M. A., Els A., Oezerdem C., Rieger J., Kuehne A., Cassara A. M., Pfeiffer H., Wetterling F., Niendorf T., Local Multi-Channel RF Surface Coil versus Body RF Coil Transmission for Cardiac Magnetic Resonance at 3 Tesla: Which Configuration Is Winning the Game?, PLoS ONE, 11, (9), 2016, p23Journal Article, 2016, DOI , TARA - Full Text
• McGroarty M., Meldrum D., Giblin S., French H.,Wetterling F., Variations in knee flexion measurements for overhead squat as measured with marker-based and markerless motion capture systems, Gait & Posture, 49, (S), 2016, p89 - 90Journal Article, 2016, DOI , TARA - Full Text
• McGroarty M., Giblin S., Meldrum D., Wetterling F., ACCURACY OF A LOW-COST NOVEL COMPUTER-VISION DYNAMIC MOVEMENT ASSESSMENT: POTENTIAL LIMITATIONS AND FUTURE DIRECTIONS, Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci., XL-5, (W8), 2016, p1 - 5Journal Article, 2016, DOI , TARA - Full Text
• Giblin S.,Smith M., Smith S., O'Brien S., McMorrow J. P., Meaney J., Wetterling F., Whole-Body Magnetic Resonance Imaging Enables Assessing Spatial Accuracy and Precision of Skeletal Joint Locations Inferred from Motion Capture Systems, 6th International Conference on 3D Body Scanning Technologies, Lugano, Switzerland, 27-28 October 2015, 2015, pp98 - 105Conference Paper, 2015, TARA - Full Text
• Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, MONITORING OF VOLUME STATUS USING A NOVEL SENSOR FOR THE ASSESSMENT OF INFERIOR VENA CAVA AREA AND COLLAPSIBILITY IN A PATIENT WITH HFREF RECEIVING ADVANCED HEART FAILURE THERAPIES, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1Conference Paper, 2023, TARA - Full Text
• Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, HOW INFERIOR VENA CAVA COLLAPSIBILITY INDEX FROM A NOVEL IMPLANTABLE SENSOR CORRELATES WITH ESTIMATED PLASMA VOLUME AND NT-PROBNP: A STUDY IN PATIENTS WITH CHRONIC HEART FAILURE, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1Conference Paper, 2023, TARA - Full Text
• Aristokleous N, Collopy D , Wetterling F., Sweeney F., O'Cearbhaill E., O"Rourke M., IN SILICO MODELLING OF FLOW-INDUCED COLLAPSE OF BLOOD VESSELS: A COMPARATIVE STUDY OF VOLUME STATUSES, 29th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (BinI 2024), Belfast, Northern Ireland, 26-27 January 2024, 2024Conference Paper, 2024, TARA - Full Text
• Wacker M, Wetterling F, Feczko T, Arkelius K, Arnou A, Lellouche J, Ansar S, Advanced theranostic nanocarrier-mediated delivery of NGF in a combination therapy trigger enhanced recovery after stroke, Journal of Cerebral Blood Flow & Metabolism, BRAIN and BRAIN-PET 2022, Glasgow, Scotland, 28 May - 1 June 2022, 42, (1S), 2022, pp263 - 264Conference Paper, 2022
• Raikhelkar J, Kebed K, Narang A, Kruse E, Weatherford S, Imamura T., Wetterling F, Nguyen A, Sayer G, Lang R., Uriel N., Inferior Vena Cava Collapsibility Index Assessed by 3D Echocardiography: A Novel Tool for the Assessment of Right Atrial Pressure in Heart Failure Patients, Journal of the American Society of Echocardiography, 32, (6), 2019, pp130 - 131Conference Paper, 2019
• F. Wetterling, S. Junge, A. Nauerth, I.M. Macrae, .A.J. Fagan, The Measurement of Spatially-Dependant Tissue Sodium Concentration Increase in a Rodent MCAO Stroke Model, ISMRM 17th Scientific Meeting, Honolulu, USA, 18-24th April , 2009Poster, 2009, TARA - Full Text
• F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, pp5255-Oral Presentation, 2010, TARA - Full Text
• F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, A Double-Tuned 1H/23Na Two Element Phased Array System for In Vivo 23Na Magnetic Resonance Microscopy at 7 T, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, pp5272Poster, 2010, TARA - Full Text
• F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, The Quantification of Tissue Sodium Concentration using 23Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, pp5173-Poster, 2010, TARA - Full Text
• Wetterling, F., Gallagher, L., Macrae, I. M., Junge, S. and Fagan, A. J., Regional and temporal variations in tissue sodium concentration during the acute stroke phase, Magnetic Resonance in Medicine, 67, (3), 2012, p740 - 749Journal Article, 2012, DOI , TARA - Full Text
• Wetterling et al., A double-tuned hydrogen-1/sodium-23 dual resonator system for tissue sodium concentration measurements in the rat brain via sodium mri, PHYSICS IN MEDICINE AND BIOLOGY, 55, 2010, p7681 - 7695Journal Article, 2010, DOI , URL
• Heiler, Langhauser, Wetterling et al., Chemical shift sodium imaging in a mouse model of thromboembolic stroke at 9.4 T, JOURNAL OF MAGNETIC RESONANCE IMAGING, 34, 2011, p935 - 940Journal Article, 2011, DOI , URL
• Wetterling et al., The localization of focal heart activity via body surface potential measurements: tests in a heterogeneous torso phantom, PHYSICS IN MEDICINE AND BIOLOGY, 54, 2009, p5395 - 5409Journal Article, 2009, DOI , URL , TARA - Full Text
• Wetterling et al., The design of a double-tuned two-port surface resonator and its application to in vivo hydrogen- and sodium-mri, Journal of Magnetic Resonance, 217, 2012, p10 - 18Journal Article, 2012, DOI , URL
• Wetterling et al., A dual resonator system for whole-body sodium-mri at 3T, 19th ANNUAL MEETING OF THE INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, Montreal, Canada, 2011, pp471Conference Paper, 2011, URL , TARA - Full Text
• Wetterling et al., Whole-body sodium-mri at 3 T using an asymmetric birdcage resonator and short echo time sequence: first images of a male volunteer , PHYSICS IN MEDICINE AND BIOLOGY, 57, 2012, p4555 - 4567Journal Article, 2012, DOI , URL , TARA - Full Text
• Hausmann, Konstandin, Wetterling et al., Apparent diffusion coefficient and sodium concentration measurements in human prostate tissue via hydrogen-1 and sodium-23 mri in a clinical setting at 3T, INVESTIGATIVE RADIOLOGY, 47, (12), 2012, p677 - 682Journal Article, 2012, DOI , URL
• Wetterling, Ansar, Handwerker, Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems, PHYSICS IN MEDICINE AND BIOLOGY, 57, (21), 2012, p6929-46Journal Article, 2012, DOI , URL , TARA - Full Text
• El-Abyad, Kalayciyan, Schad, Wetterling, Enhancing the detector sensitivity of a radio-frequency surface resonator for potassium-39 mri at 18.7 mhz: probing different geometries at various temperatures, IEEE XPLORE, 42nd European Microwave Conference, Amsterdam, 29 Oct - 1 Nov, 2012, pp444 - 7Conference Paper, 2012, URL , TARA - Full Text
• Kalayciyan, Wetterling, Neudecker et al., Bilateral kidney sodium-MRI: Enabling accurate quantification of renal sodium concentration through a two-element phased array system, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2013Journal Article, 2013, DOI , URL
• Friedrich Wetterling, The Detection of Infarcted Stroke Tissue via Localised Sodium Concentration Measurements: A Non-Invasive Approach, Trinity College Dublin, 2009Thesis, 2009, URL , TARA - Full Text
• Wetterling, Mok, McGoldrick, Basu, Non-Destructive Investigation of Glass Fiber Reinforced Composites via Magnetic Resonance Imaging, Key Engineering Materials, 569-570, 2013, p126 - 131Journal Article, 2013, DOI , URL
• Danisch, Kalayciyan, Wetterling, Schad, Bilateral 23Na MR imaging of the breast and quantification of sodium concentration, ZEITUNG FUER MEDIZINISCHE PHYSIK, 24, (1), 2014, p65-72Journal Article, 2014, DOI , URL , TARA - Full Text
• Sack M, Wetterling F, Sartorius A, Ende G, Weber-Fahr W, Signal-to-noise ratio of a mouse brain (13) C CryoProbe system in comparison with room temperature coils: spectroscopic phantom and in vivo results., NMR in biomedicine, 27, (6), 2014, p709-15Journal Article, 2014, DOI , URL , TARA - Full Text
• Sebastian Weingärtner, Friedrich Wetterling, Simon Konstandin, Marc Fatar, Eva Neumaier-Probst, Lothar Schad, Scan time reduction in 23Na-magnetic resonance imaging using the chemical shift imaging sequence: Evaluation of an iterative reconstruction method, ZETUNG FÜR MEDIZINISCHE PHYSIK, 2014, p1 - 11Journal Article, 2014, URL
• Wetterling, F., Gallagher, W. Holmes, L., Macrae, I. M., and Fagan, A. J., Temporal water mobility and sodium intensity measurements in penumbra and core tissue during acute stroke, International Society for Magnetic Resonance in Medicine, Montreal, Canada, 2011, pp470-Conference Paper, 2011, DOI , URL , TARA - Full Text
• Friedrich Wetterling, Lindsay Gallagher, Jim Mullin, William M Holmes, Chris McCabe, I Mhairi Macrae and Andrew J Fagan, Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time, Journal of Cerebral Blood Flow and Metabolism, 35, (1), 2015, p103 - 110Journal Article, 2015, DOI , TARA - Full Text

• Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Shriram Raghunathan, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless vascular monitoring implants', USPTO, 10806352, 2020, 24 March 2024, Foundry Innovation & Research1, Ltd.,Dublin(IE)Patent, TARA - Full Text
• Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore', USPTO, 2023, 26 March 2024, Foundry Innovation and Research 1 LtdPatent, TARA - Full Text

• Title

  Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet
  Summary

  Cardiovascular diseases (CVD) are the leading cause of death with 60% of CVDs associated with coronary artery diseases (CAD). CAD is the major cause of myocardial infarction (MI), commonly known as heart attack, which can be life threatening and places a huge socio-economic burden on the EU. The most widely used therapy for CAD is revascularization, and myocardial viability is a determining factor and predictor for patient outcomes. Magnetic resonance imaging (MRI) has become a mainstay of clinical diagnosis, but so far has seen limited use in the study of the heart. Here I aim to unlock the potential of myocardial viability imaging with physiometabolic MRI to provide a new instrument for the diagnosis and assessment of therapy success of CAD. Therefore I propose a quantitative approach based on MRI of sodium (23Na) that will allow me to observe new features of the working heart, at a level of resolution that will be highly valuable in understanding, finely diagnosing, and designing treatments for CVD. To meet this goal I pursue the development of cutting edge sodium MRI technology. Its capacity for quantitative assessment of sodium tissue content will be validated in model systems and in healthy subjects. The clinical applicability of 23Na MRI for viability imaging will be examined in revascularized MI patients. For this purpose I will leverage the sensitivity gain inherent to ultrahigh field MRI (B0"7.0 T), capitalize on my outstanding expertise in the field of physiometabolic MRI and build on my interdisciplinary skills formed around MRI physics. In this project, this expertise will be taken to the next level to elucidate the progression of sodium concentration in ischemic myocardial tissue. This research will eliminate the main barriers to the study of tissue viability and will open entirely new possibilities for non-invasive, in vivo phenotyping as a tool for individualised medicine tailored to offset a major socio-economic burden on the EU induced by CVD.
  Funding Agency

  European Commission
  Date From

  1 January 2018
  Date To

  31 December 2019
• Title

  A non-invasive deep brain stimulation device
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  2013
  Date To

  2014
• Title

  Development of a nuclear magnetic resonance imaging technique for the accurate detection and quantification of tissue sodium concentration in animal models of disease.
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  01/05/2006
  Date To

  27/09/2009

Computer science - Graphics, visualisation and imaging science, Materials Science, Medical Engineering, Biotechnology and devices (including medical laboratory technologies and informatics), Electrical & electronic engineering, Other Biological Sciences, Wind Energy, Physics, Communication engineering and systems; telecommunications,

• Enterprise Ireland Commercialization Feasibility Grant (15.000EUR): A non-invasive deep brain stimulation device 2014
• Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'In vivo Hydrogen-1, Sodium-23, Phosphorus-31, and Potassium-39 Magnetic Resonance Imaging after Middle Cerebral Artery Occlusion' 2012
• Selected member (by research proposal) of the 4th excellence initiative "molecular and disease-related imaging" 2010 German research association (DFG), Aachen, Germany 2010
• AstraZeneca Award (British Chapter of the International Society for Magnetic Resonance Imaging) for 'outstanding, innovative research with potential utility in medicine or medical research' 2009
• Intel Prize at DCU Hackathon for presenting a low cost MRI solution to assess beef quality (as part of the Bó Selecta team) 2015
• Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'Temporally-resolved imaging of renal sodium-23 changes after furosemid injection' 2012
• Siemens Young Investigator Award (German Society for Medical Physics), 'Sodium Concentration as a Marker for Tissue Viability after Ischaemic Stroke' 2010
• Selected member (by research proposal) of the 4th excellence initiative for molecular and disease-related imaging; German Science Foundation (DFG), Aachen, Germany 2010
• AI Ireland award for best use of robotic process automation and cognitive Artificial Intelligence (AI) 2021
• Poster Prize (Ultra High Field Symposium, Berlin), Multi-nuclear magnetic resonance imaging at ultra-high magnetic field strength: probing sodium-23, chlorine-35, potassium-39, and phosphorus-31 signals in tissue deprived of arterial blood supply 2013
• Award for the best oral presentation from a young scientist (Association of Physical Scientists in Medicine), 'A Dual RF Resonator System for Sodium MRI' 2008