Trinity Centre for Biomedical Engineering

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Professor Paula Murphy

Professor Paula Murphy

Professor, Zoology

Biography

Paula Murphy's research interests are in the genetic regulation of embryonic development, and she has been carrying out research in this field since starting postgraduate studies towards her doctoral degree in 1987. The relationship between gene expression patterns and gene function has been a prominent part of her work, and detailed expression analysis is one of her specialisations. The focus of her current research is on understanding the molecular basis of tissue formation and morphogenesis in the vertebrate embryo, in particular how mechanical signals integrate with molecular pathways in guiding spatially organized tissue differentiation. She uses mouse and chick animal models to reveal the effects of disrupting regulatory mechanisms to test functional hypotheses; making use of mutant mouse lines. The research team is currently pioneering approaches to specifically manipulate gene function using CRISPR interference directly in vivo in the chick embryo. This permits targeting of specific tissues in a whole embryo context. The lab specializes in imaging molecular events within the 3D morphological context of the embryo. Her research career spans experience in a number of top international research institutions (Medical Research Council HUman Genetics Unit, Edinburgh; The University of Rome (La Sapienza); Ecole Normale Supeieur, Paris; The biotechnology Institute of Oslo, University of Oslo) and she continues to collaborate with international colleagues in the US and Europe.

Publications and Further Research Outputs

  • Rolfe, R.A., Kenny, E.M., Cormican, P., Murphy, P., Transcriptome analysis of the mouse E14.5 (TS23) developing humerus and differential expression in muscle-less mutant embryos lacking mechanical stimulation, Genomics Data, 2, 2014, p32-36Journal Article, 2014, DOI , URL , TARA - Full Text
  • Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J, Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis., American journal of physiology. Renal physiology, 311, (1), 2016, pF35-F45Journal Article, 2016, DOI , URL
  • Mc Laughlin D, Murphy P, Puri P, Notochord manipulation does not impact oesophageal and tracheal formation from isolated foregut in 3D explant culture., Pediatric surgery international, 32, (1), 2016, p29-35Journal Article, 2016, DOI , URL
  • Shea CA, Rolfe RA, Murphy P, The importance of foetal movement for co-ordinated cartilage and bone development in utero : clinical consequences and potential for therapy., Bone & joint research, 4, (7), 2015, p105-16Journal Article, 2015, DOI , URL , TARA - Full Text
  • Mohammadkhah M, Murphy P, Simms C.K, The in vitro passive elastic response of chicken pectoralis muscle to applied tensile and compressive deformation, Journal of the Mechanical Behavior of Biomedical Materials, 62, 2016, p468 - 480Journal Article, 2016, DOI , URL
  • Saha, A., Rolfe, R., Carroll, S., Kelly, D.J., Murphy, P., Chondrogenesis of embryonic limb bud cells in micromass culture progresses rapidly to hypertrophy and is modulated by hydrostatic pressure, Cell and Tissue Research, 368, (1), 2017, p47-59Journal Article, 2017, DOI , URL
  • Mohammadkhah M, Simms C.K, Murphy P, Visualisation of Collagen in fixed skeletal muscle tissue using fluorescently tagged Collagen binding protein CNA35, Journal of the Mechanical Behavior of Biomedical Materials, 66, 2017, p37 - 44Journal Article, 2017, DOI , URL
  • Murphy, P., Dowds, B.C., McConnell, D.J., Devine, K.M. , Oxidative stress and growth temperature in Bacillus-Subtilis, Journal OF Bacteriology, 169, (12), 1987, p5766 - 5770Journal Article, 1987, URL
  • Mohammadkhah M, Murphy P, Simms CK., Collagen fibril organization in chicken and porcine skeletal muscle perimysium under applied tension and compression., Journal of the Mechanical Behavior of Biomedical Materials, 77, 2018, p734 - 744Journal Article, 2018, DOI , URL
  • Pratik Narendra Pratap Singh, Claire Shea, Shashank Kumar Sonker, Rebecca Rolfe, Ayan Ray, Sandeep Kumar, Pankaj Gupta, Paula Murphy, Amitabha Bandyopadhyay, Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement, Development, 145, (5), 2018, pdev153460-Journal Article, 2018, DOI , URL
  • Rolfe R., Shea C., Singh P., Bandyopadhyay A., Murphy P., Uncovering the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint, Philosophical Transactions B, 373, (1759), 2018, p1 - 12Journal Article, 2018, DOI
  • Rolfe RA, Shea CA, Singh PNP, Bandyopadhyay A, Murphy P, Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint, Philisophical Transactions of the Royal society, 2018Journal Article, 2018, DOI , URL , TARA - Full Text
  • Dowds, B.C., Murphy, P., McConnell, D.J. and Devine, K.M., Relationship among oxidative stress, growth cycle and sporulation in Bacillus subtilis, Journal of Bacteriology, 169, (12), 1987, p5771 - 5775Journal Article, 1987, URL
  • Murphy, P., Davidson, D.R. and Hill, R.E., Segment specific expression of a homeobox-containing gene in the mouse hindbrain, Nature, 341, 1989, p156 - 159Journal Article, 1989, DOI , URL
  • Murphy, P. and Hill, R.E., Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segementation of the hindbrain, Development, 111, (1), 1991, p61 - 74Journal Article, 1991, URL , TARA - Full Text
  • Morriss-Kay, G.M., Murphy, P., Hill, R.E. and Davidson, D.R., Effects of retinoic acid excess on expression oh Hox 2.9 and Krox 20 and on morphological segmentation in the hindbrain of mouse embryos, EMBO Journal, 10, 1991, p2985 - 2995Journal Article, 1991
  • Retinoid induced alterations of segmental organisation and gene expression in the mouse hindbrain. in, editor(s)G.M.Morriss-Kay (ed.) , Retinoids in normal development and teratogenesis, Oxford, Oxford University Press, 1992, pp229 - 240, [Murphy, P., Morriss-Kay, G.M., Hill, R.E. and Davidson, D.R.]Book Chapter, 1992
  • Multiple myogenic cell precursors and their possible role in muscle histogenesis in, editor(s)A.M.Kelly and H.M.Blau (eds.) , Neuromuscular development and disease, New York, Raven Press, 1992, pp183 - 195, [Cossu, G., Cusella-De Angelis, M.G., De Angelis, L., Mezzogiorno, A., Murphy, P., Coletta, M., Vivarelli, E., Bouche, M. and Molinaro, M.]Book Chapter, 1992
  • Becker, N., Setanidou, T., Murphy, P., Mattei, M.G., Topilko, P., Nieto, A., Wilkinson, D.G., Charnay, P. and Gilardi-Hebenstreit, P., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain, Mechanisms of Development, 47, (1), 1994, p3 - 17Journal Article, 1994, DOI , URL
  • Murphy, P., Topilko, P., Schneider-Maunoury, Seitanidou, T. and Charnay, P., The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development., Development, 122, (9), 1996, p2847 - 2857Journal Article, 1996, URL , TARA - Full Text
  • Topilko, P., Murphy, P. and Charnay, P., Embryonic development of Schwann cells: multiple roles for neuregulins along the pathway, Molecular and Cellular Neuroscience, 8, (2-3), 1996, p71 - 75Journal Article, 1996, DOI , URL
  • Skammelsrud, N., Martin, E.R., Murphy, P., Khuu, C., Frengen, E. and Kolsto, A-B., The gene for human transcription factor TCF11 is located telomeric to D17S1827, BTR and HP1Hsb on chromosome 17q22, Genetic Analysis, 15, (6), 1999, p217 - 222Journal Article, 1999, DOI , URL
  • Cossu, G., De Angelis, L., Borello, U., Berarducci, B., Buffa, V., Sonnino, C., Coletta, M., Vivarelli, E., Bouche, M., Lattanzi, L., Tosoni, D., Di Donna, S., Berghella, L., Salvatori, G., Murphy, P., Cusella-De Angelis, M.G. and Molinaro, M., Determination, diversification and multipotency of mammalian myogenic cells., International Journal of Developmental Biology, 44, 2000, p699 - 706Journal Article, 2000, URL , TARA - Full Text
  • Husberg, C., Murphy, P., Martin, E. and Kolsto, A.B., Two domains of the human bZIP transcription factor TCF11 are necessary for transactivation, Journal of Biological Chemistry, 276, (21), 2001, p17641 - 17652Journal Article, 2001, DOI , URL , TARA - Full Text
  • Johnsen, O. and Murphy, P., Prydz, H. and Kolsto, A-B., Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription, Nucleic Acids Research, 26, (2), 1998, p512 - 520Journal Article, 1998, URL , TARA - Full Text
  • Murphy, P. and Kolsto, A.B., Expression of the bZIP transcription factor TCF11 and its potential dimerisation partners during development, Mechanisms of Development, 97, (1-2), 2000, p141 - 148.Journal Article, 2000, DOI , URL
  • Myhrstad, M., Husberg, C., Murphy, P., Moskaug, J.O. and Kolsto, A.B., TCF11/Nrf1 over-expression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine sythetase (GCS) heavy subunit promoter., Biochimica Biophysica Acta, 1517, (2), 2001, p212 - 219Journal Article, 2001, DOI , URL
  • Husberg, C., Murphy, P., Bjorgo, E., Kalland, K-H. and Kolsto, A-B., Cellular localisation and nuclear export of the human bZIP transcription factor TCF11, Biochimica Biophysica Acta, 1640, (2-3), 2003, p143 - 151Journal Article, 2003, DOI , URL
  • V Sotiriou, RA Rolfe, P Murphy, NC Nowlan, Effects of abnormal muscle forces on prenatal joint morphogenesis in mice, Jounral of Orthopaedic Research, 37, (11), 2019, p2287 - 2296Journal Article, 2019, DOI , TARA - Full Text
  • Shea C.A., Rolfe R.A., McNeill H., AND Murphy P., Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation, Developmental Dynamics , 249, (4), 2020, p523 - 542Journal Article, 2020, DOI , TARA - Full Text
  • Rolfe, RA. Scanlon-O' Callaghan, D. and Murphy P., Joint development recovery on resumption of embryonic movement following paralysis, Disease Models and Mechanisms , 14, (4), 2021, phttps://doi.org/10.1242/dmm.04Journal Article, 2021, URL , TARA - Full Text
  • Rolfe, RA. Shea, CA. and Murphy P., Geometric analysis of chondrogenic self-organisation of embryonic limb bud cells in micromass culture., Cell and Tissue Research , 2022Journal Article, 2022, TARA - Full Text
  • Shea, C.A. and Murphy, P , The Primary Cilium on Cells of Developing Skeletal Rudiments; Distribution, Characteristics and Response to Mechanical Stimulation, Frontiers in Cell and developmental Biology , 2021, phttps://doi.org/10.3389/fcell.Journal Article, 2021, URL
  • Peterson BE., Rolfe RA., Kunselman A., Murphy P., and Szczesny S., Mechanical Stimulation via Muscle Activity is Necessary for the Maturation of Tendon Multiscale Mechanics during Embryonic Development, Frontiers in Cell and Developmental Biology , 2021, p10.3389/fcell.2021.725563Journal Article, 2021, DOI , URL , TARA - Full Text
  • Darker CD., Mullin M., Doyle L., Tanner M., McGrath D., Doherty L., Dreyer-Gibney K., Barret EM., Flynn D., Ivers J, Burke E, Ryan M., McCarron M., Murphy P., et alia, Developing a healthy university campus in Trinity College Dublin - overview and an outline process evaluation , Health Promotion International, 2021Journal Article, 2021, DOI , URL
  • Murphy P., Armit C., Hill B., Venkataraman S., Frankel P., Baldock R. and Davidson D. , Integrated analysis of Wnt signalling system component gene expression, Development , 149, (16), 2022, pdoi: 10.1242/dev.200312. EpubJournal Article, 2022, TARA - Full Text
  • Hill, Bill. Husz, Zost. Armit, Chris. Davidson, Duncan R. Murphy, Paula. Baldock, Richard A., WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data, 2022Journal Article, 2022, DOI , TARA - Full Text
  • Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions in, editor(s)Boris Kablar , Roles of Skeletal Muscle in Organ Development, Springer Nature, 2023, [Paula Murphy and Rebecca Rolfe]Book Chapter, 2023, DOI , TARA - Full Text
  • Gallagher, S,. Murphy, P., Implementing inter-institutional lifelong sustainability education: The UNI-ECO e-learning case study, Irish Journal of Academic Practice, 11, (2), 2024Journal Article, 2024, URL
  • Rolfe RA, Basturkmen ET, Sliney L, Hayden G, Dunne N, Buckley N, McCarthy H, Szczesney SE and Murphy P., Embryo movement is required for limb tendon maturationJournal Article
  • Rolfe RA, Basturkmen EB, Sliney L, Hayden G, Dunne N, Buckley N, McCarthy H, Szczesney SE, and Murphy P., Embryo Movement is required for limb tendon maturation, Frontiers in Cell and Developmental Biology, 2024Journal Article, 2024, DOI
  • Lioubinski O, Alonso MT, Alvarez Y, Vendrell V, Garrosa M, Murphy P, Schimmang T., FGF signalling controls expression of vomeronasal receptors during embryogenesis., Mechanisms of Development, 123, (1), 2006, p17 - 23Journal Article, 2006, DOI , URL
  • Ugo Borello, Barbara Berarducci, Paula Murphy, , The Wnt/ß-catenin pathway regulates the Shh-mediated Myf5 , Development, 133, 2006, p3723 - 3732Journal Article, 2006, DOI , URL , TARA - Full Text
  • Nowlan N., Murphy P. and Prendergast P. , Computation of stresses in the growing embryonic chick limb. , II International Conference on Computational Bioengineering, II International Conference on Computational Bioengineering, Lisbon, Portugal, September 14-16 2005, edited by H Rodrigues et al. , 2005, pp861 - 872Conference Paper, 2005
  • Suzanne F. C. Miller, Kristen Summerhurst, Annette E. Rünker, Géraldine Kerjan, Roland H. Friedel, Alain Chédotal, Paula Murphy and Kevin J. Mitchell, Expression of Plxdc2/TEM7R in the developing nervous system of the mouse, Mechanisms of Development, 7, (5), 2007, p635 - 644Journal Article, 2007, DOI , URL
  • Nowlan, NC, Murphy, P, Prendergast, PJ, Mechanobiology of embryonic limb development, Annals of the New York Academy of Sciences, 1101, 2007, p389 - 411Journal Article, 2007, DOI , URL , TARA - Full Text
  • Foolen J., van Donkelaar C., Nowlan N., Murphy P., Huiskes R. and Ito K., Collagen orientation in periosteum and perichondrium is aligned with preferential directions of tissue growth., Journal of Orthopaedic Research, 26, (9), 2008, p1263 - 1268Journal Article, 2008, DOI , URL
  • Sato H., Murphy P., Giles S., Bannigan J., Takayasu H. and Puri P., Visualising expression patterns of Shh and Foxf1 genes in the foregut and lung buds by Optical Projection Tomography. , Pediatric Surgery International, 24, (1), 2008, p3 - 11Journal Article, 2008, DOI , URL
  • Kristen Summerhurst, Margaret Stark, James Sharpe, Duncan Davidson and Paula Murphy, 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts 19)., Gene Expression Patterns, 8, (5), 2008, p331 - 348Journal Article, 2008, DOI , URL , TARA - Full Text
  • Malcolm E. Fisher, Allyson K. Clelland, Andrew Bain, Richard A. Baldock, Paula Murphy, Helen Downie, Cheryll Tickle, Duncan R. Davidson and Richard A. Buckland., Integrating technologies for comparing 3D gene expression domains in the developing chick limb, Developmental Biology, 317, (1), 2008, p13 - 23Journal Article, 2008, DOI , URL
  • Nowlan N, Murphy P, Prendergast PJ, Dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones, Journal of Biomechanics, 41, (3), 2008, p249 - 258Journal Article, 2008, DOI , URL , TARA - Full Text
  • N. Nowlan, P. Murphy and P.J. Prendergast, Mechanical stimuli resulting from embryonic muscle contractions promote avian periosteal bone collar formation', Summer Bioengineering Conference,, Colorado , American Society of Mechanical Engineers, 2007Conference Paper, 2007
  • Nowlan, N.C. , Murphy P. and Prendergast, P.J., Mechanical Stimuli Resulting From Embryonic Muscle Contractions Promote Avian Periosteal Bone Collar Formation, Proceedings of the 2007 Summer Bioengineering Conference of the American Society of Mechanical Engineering, 2007 Summer Bioengineering Conference of the American Society of Mechanical Engineering, American Society of Mechanical Engineering, 2005, pp833-834Conference Paper, 2005
  • Nowlan, N.C. , Murphy P. and Prendergast, P.J., The characterisation of mechanical stresses in the growing avian embryonic limb, Proceedings of the 5th World Congress of Biomechanics, 5th World Congress of Biomechanics, 2006Conference Paper, 2006
  • Nowlan, N.C., Murphy P. and Prendergast, P.J., The calculation of mechanical stresses in the growing avian embryonic limb using optical projection tomography, Proceedings of the 2006 Summer Bioengineering Conference of the American Society of Mechanical Engineering, Summer Bioengineering Conference of the American Society of Mechanical Engineering, 2006Conference Paper, 2006
  • Nowlan, N.C. , Murphy P. and Prendergast, P.J. , The influence of mechanical forces in the growing embryonic limb, Proceedings of the 52 nd Annual Meeting of the Orthopaedic Research Society , 52 nd Annual Meeting of the Orthopaedic Research Society , Orthopaedic Research Society , 2006, pp31Conference Paper, 2006
  • Nowlan, N.C., Murphy P. and Prendergast, P.J, Computation of stresses in the growing embryonic chick limb, Proceedings of the 2 nd International Conference on Computational Bioengineering , 2nd International Conference on Computational Bioengineering , edited by Rodrigues, et al., , 2, IST Press. Lisbon., 2005, pp861-872Conference Paper, 2005
  • Foolen, J., van Donkelaar, Corrinus C., Murphy, Paula, Huiskes, Rik, Ito, Keita, Residual periosteum tension is insufficient to directly modulate bone. , Journal of Biomechanics, 42, (2), 2009, p152 - 157Journal Article, 2009, DOI , URL
  • Dalton Victoria S., Borich Suzanne M., Murphy P. and Roberts B.L., Brain-Derived Neurotrophic Factor mRNA expression in the Brain of the Teleost Fish, Anguilla anguilla, the European eel., Brain, Behaviour and Evolution, 73, (1), 2009, p43 - 58Journal Article, 2009, DOI , URL
  • Nowlan, N., Prendergast P.J. and Murphy, P., Identification of Mechanosensitive Genes during Embryonic Bone Formation. , PLoS Computational Biology, 4, (12), 2008, pe1000250-Journal Article, 2008, TARA - Full Text
  • Karen A. Roddy, Niamh C Nowlan, Patrick J. Prendergast, and Paula Murphy, 3D representation of the developing chick knee joint: a novel approach integrating multiple components, Journal of Anatomy, 214, (3), 2009, p374 - 387Journal Article, 2009, DOI , URL
  • Vendrell V., Summerhurst K, Sharpe J, Davidson D, Murphy P, Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo, Gene Expression Patterns, 2009Journal Article, 2009, DOI , TARA - Full Text
  • Sato, H., Murphy, P., Hajduk, P., Takayasu, H., Kitagawa, H. and Puri, P. , Sonic hedgehog gene expression in nitrofen induced hypoplastic lungs in mice. , Pediatric Surgery International, 25, (11), 2009, p967 - 971Journal Article, 2009, DOI
  • Hajduk P, Murphy P, Puri P., Fgf10 gene expression is delayed in the embryonic lung mesenchyme in the adriamycin mouse model., Paediatric Surgery International, 26, (1), 2009, p23 - 27Journal Article, 2009, DOI
  • Niamh C. Nowlan, Céline Bourdon, Shahragim Tajbakhsh, Gérard Dumas, Patrick J. Prendergast and Paula Murphy, Developing bones are differentially affected by compromised skeletal muscle formation, Bone, 46, 2010, p1275-1285Journal Article, 2010, DOI , TARA - Full Text
  • Hajduk P, Murphy P, Puri P, Mesenchymal expression of Tbx4 gene is not altered in Adriamycin mouse model., Pediatric surgery international, 26, (4), 2010, p407-11Journal Article, 2010, DOI
  • Nowlan, N. C., Sharpe, J., Prendergast P.J. and Murphy P. , Mechanobiology of Embryonic Skeletal Development: Insights from Animal Models., Birth Defects Research Part C: Embryo Today, 90, (3), 2010, p203-213Journal Article, 2010, DOI
  • Karen A. Roddy, Geraldine M. Kelly, Maarten H. van Esc, Paula Murphy, and Patrick J. Prendergast, Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint, Journal of Biomechanics, 44, (11), 2011, p143-149Journal Article, 2011, TARA - Full Text
  • Takayasu H, Murphy P, Sato H, Doi T, Puri P., Embryonic Wnt gene expression in the nitrofen-induced hypoplastic lung using 3-dimensional imaging, Journal of Paediatric Surgery, 45, (11), 2010, p2129 - 2135Journal Article, 2010, DOI
  • Miller-Delaney, S., Lieberam, I., Jessell, T., Murphy P. and Mitchell, K. , Plxdc2 is a mitogen for neural progenitors, PLoS ONE, 6, (1), 2011, pe14565Journal Article, 2011, DOI , URL , TARA - Full Text
  • Nowlan N.C., Dumas, G., Tajbakhsh S., Prendergast P. And Murphy P. , Passive Movement Due to External Mechanical Stimulation Plays a Role in Embryonic Skeletal Development. , Biomechanics and Modeling in Mechanobiology , epub ahead of print, 2011Journal Article, 2011
  • Roddy KA, Prendergast PJ, Murphy P, Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos., PloS one, 6, (2), 2011, pe17526Journal Article, 2011, DOI , TARA - Full Text
  • Piotr Hajduk, Hideaki Sato, Prem Puri and Paula Murphy , Abnormal Notochord Branching is Associated with Foregut Abnormalities in an Adriamycin Treated Mouse Model, PLoS ONE, 6, (11, e27635), 2011Journal Article, 2011, TARA - Full Text
  • Nowlan, N.C., Dumas, G., Tajbakhsh, S., Prendergast, P.J., Murphy, P. , Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis , Biomechanics and Modeling in Mechanobiology, 11, (1-2), 2011, p207-219Journal Article, 2011, TARA - Full Text
  • Nowlan, N.C. , Prendergast, P.J. , Tajbakhsh, S., Murphy, P., Identifying candidate mechanoregulators of skeletal development, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, 11th ASME Summer Bioengineering Conference, SBC2009, Lake Tahoe, 17-21 June, PART A,, 2009, pp149-150Conference Paper, 2009
  • Hajduk, Piotr; May, Alison; Puri, Prem; Murphy, Paula , The Effect of Adriamycin Exposure on the Notochord of Mouse Embryos, Birth Defects Research Part B: Developmental and Reproductive Toxicology , 95, 2012, p175 - 183Journal Article, 2012, DOI
  • Martin, Audrey; Maher, Stephanie; Summerhurst, Kristen; Davidson, Duncan; Murphy, Paula , Differential deployment of Paralogous Wnt genes in the Mouse and Chick Embryo during Development. , Evolution and Development, 142, 2012, p178 - 196Journal Article, 2012, DOI
  • Tatiana Vinardell, Rebecca A. Rolfe, Conor T. Buckley, Eric G. Meyer, Mark Ahearne, Paula Murphy and Daniel J. Kelly, Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells, European Cells and Materials, 23, 2012, p121 - 134Journal Article, 2012
  • Hajduk P, Sato H, Puri P, Murphy P, Abnormal notochord branching is associated with foregut malformations in the adriamycin treated mouse model., PloS one, 6, (11), 2011, pe27635Journal Article, 2011, DOI , TARA - Full Text
  • Mc Laughlin, Danielle, Hajduk, Piotr, Murphy, Paula, Puri, Prem, Adriamycin-Induced Models of VACTERL Association, Molecular Syndromology, 4, (1-2), 2013, p46 - 62Journal Article, 2013, DOI
  • Rolfe Rebecca, Roddy Karen, and Murphy Paula, Mechanical Regulation of Skeletal Development , Current Osteoporosis Reports, 11, (2), 2013, p107 - 116Journal Article, 2013, DOI , URL , TARA - Full Text
  • Sato H, Murphy P, Giles S, Bannigan J and Puri P, Optical Projection Tomography as a new tool for visualising gene expression, Reproductive toxicology , 24, (1), 2007, p66 - 66Journal Article, 2007
  • Wong, F., Welten, M.C.M., Anderson, C., Bain, A.A., Liu, J., Wicks, M.N., Pavlovska, G., (...), Burt, D.W., eChickAtlas: An introduction to the database, Genesis, 51, (5), 2013, p365-371Journal Article, 2013, DOI
  • Rolfe RA, Nowlan NC, Kenny EM, Cormican P, Morris DW, Prendergast PJ, Kelly D, Murphy P., Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways., BioMedCentral Genomics, 15, 2014, p1 - 23Journal Article, 2014, TARA - Full Text
  • Mc Laughlin D, Murphy P, Puri P, Altered Tbx1 gene expression is associated with abnormal oesophageal development in the adriamycin mouse model of oesophageal atresia/tracheo-oesophageal fistula., Paediatric Surgery International, 30, (2), 2014, p143 - 149Journal Article, 2014
  • Sato H, Hajduk P, Furuta S, Wakisaka M, Murphy P, Puri P, Kitagawa H, Effect of abnormal notochord delamination on hindgut development in the Adriamycin mouse model., Pediatric Surgery International , 29, (11), 2013, p1209 - 1216Journal Article, 2013
  • Hill, Bill. Husz, Zost. Armit, Chris. Davidson, Duncan R. Murphy, Paula. Baldock, Richard A., WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data, biorXiv , 2022Journal Article
  • Murphy, Paula. Summerhurst, Kristen. Brady, Gareth. Vendrell, Victor. Frankel, Patrick. Redmond, Martina. Maddock, Jessica. Killion-Connolly, Somantha. Armit, Chris. Hill, Bill. Venkatarman, Shanmugasundaram. Yiwen, Sun. Baldock, Richard. Davidson, Duncan. , Wnt Pathway Analysis mapped gene-expression data, University of Edinburgh (datashare) , 2021Dataset, DOI
  • Murphy, Paula. Summerhurst, Kristen. Brady, Gareth. Vendrell, Victor. Frankel, Patrick. Redmond, Martina. Killion-Connolly, Somantha. Armit, Chris. Hill, Bill. Venkatarman, Shanmugasundaram. Yiwen, Sun. Baldock, Richard. Davidson, Duncan. Maddock, Jessica, Wnt Pathway Analysis mapped gene-expression point-cloud data, University of Edinburgh (datashare) , 2021Dataset, DOI
  • Nowlan, N. C., P. Murphy & P. J. Prendergast. , The influence of mechanical forces in the growing embryonic limb. , Transactions of the 52nd Annual Meeting of the Orthopaedic Research Society, the 52nd Annual Meeting of the Orthopaedic Research Society, Chicago, Illinois, edited by Burr, D. B , 31, 2006, ppno. 123-Conference Paper
  • Miller S.F., Runker A.E., Kerjan G., Friedel R.H., Murphy P., Mitchell K.J., TEM7R in the developing mammalian nervous system. , International Journal of Developmental Neuroscience , 24, 2006, p598 - 598Journal Article

Research Expertise

The focus of the research is on understanding the molecular basis of tissue formation and morphogenesis in the vertebrate embryo, in particular how mechanical signals integrate with molecular pathways in guiding spatially organized tissue differentiation. The laboratory uses both mouse and chick animal models to reveal the effects of disrupting regulatory mechanisms to test functional hypotheses; making use of mutant mouse lines. This work is noteworthy for synergistic interdisciplinary collaboration, yet maintaining a focus and leadership in developmental biology. My independent research is built upon high impact work during my PhD and post-doctoral fellowships, initially establishing my independent research lab at Trinity College with a Science Foundation Ireland Principal Investigator award, using 3D imaging to integrate multiple gene expression patterns across time and space in the mouse embryo; work that has recently culminated in release of a valuable 3D mapped data resource for the Developmental Biology Community (https://journals.biologists.com/dev/article/276332/Signalling-pathway-Wnt-igration) My focus on morphogenesis of the developing limb in particular, and how spatially organized tissue specification occurs, led to collaborative research with colleagues in the Trinity Centre for Bioengineering and I have built a very successful track-record of collaborative research with engineers. These interdisciplinary collaborations have had a transformative effect, bringing a developmental biology perspective and understanding, enabling a deeper understanding of the role mechanics plays in morphogenesis. I have co-advised engineering students who have become very successful independent researchers themselves and are now using embryological models in their independent research. We have used transcriptomics to show that Wnt siganlling is central to the mechanoresponse in the skeleton and the openly available data were the 5th most highly viewed mouse data of 18,000 database entries, highlighting the utility, timeliness and quality of the work (Rolfe et al 2014). Significantly, we proposed a new model to explain the correct spatial differentiation of permanent articular cartilage at the joint and the transient cartilage that will serve as an anlage for later bone development (Rolfe et al 2018; Singh et al 2018).

Recognition

  • Fellow of Trinity College Dublin 2008
  • Science Foundation Ireland. Investigator Programme Grant September 2003 - September 2007
  • Human Frontiers Science Program fellowship 1993
  • Medical Research Council Studentship 1988
  • Norwegian Cancer Society (Den Norske Kreftforening) research grants 1996, 1997, 1998, 1999
  • EMBO long term research fellowship 1991
  • Welcome Trust Research Grant 2010-2014