Professor Tríona Lally

Professor in BioEngineering, Mechanical, Manuf & Biomedical Eng

lallyca@tcd.ie 3531896 3159 http://www.mee.tcd.ie/biomaterials/People/CLally

Biography

Dr. Caitríona Lally received her BEng (Mechanical Engineering) and MEng (Biomedical Engineering) degrees from University of Limerick and later obtained a PhD from Trinity College Dublin in the area of arterial biomechanics and cardiovascular stenting. In March 2004 she took up a lecturing position in the School of Mechanical & Manufacturing Engineering at Dublin City University, and was appointed senior lecturer in 2014. In 2015, she joined the Department of Mechanical & Manufacturing Engineering in Trinity College Dublin as a Professor in Bioengineering where she continues to carry out research focused on arterial tissue mechanics, vascular imaging, vascular mechanobiology and tissue engineering. She has secured considerable research funding from SFI, Enterprise Ireland and the IRC and was awarded an ERC starting grant in 2014.

Publications and Further Research Outputs

Peer-Reviewed Publications
Non-Peer-Reviewed Publications

Flamini V, Creane A.P, Kerskens C.M, Lally C, Imaging and finite element analysis: A methodology for non-invasive characterization of aortic tissue, Medical Engineering and Physics, 37, (1), 2015, p48 - 54Journal Article, 2015, DOI , URL
McCartney, W.T., Galvin, E., Cummins, C., Lally, C., Mac Donald, B.J., Use of a biodegradable magnesium implant for Osseous fixation in four cases, International Journal of Applied Research in Veterinary Medicine, 13, (3), 2015, p171-174Journal Article, 2015
Zahedmanesh, H., Van Oosterwyck, H., Lally, C., A multi-scale mechanobiological model of in-stent restenosis: deciphering the role of matrix metalloproteinase and extracellular matrix changes, Computer Methods in Biomechanics and Biomedical Engineering, 17, (8), 2014, p813-828Journal Article, 2014
Brackmann, C., Dahlberg, J.-O., Vrana, N.E., Lally, C., Gatenholm, P., Enejder, A., Non-linear microscopy of smooth muscle cells in artificial extracellular matrices made of cellulose, Journal of Biophotonics, 5, (5-6), 2012, p404-414Journal Article, 2012
Campbell, E.M., Cahill, P.A., Lally, C., Investigation of a small-diameter decellularised artery as a potential scaffold for vascular tissue engineering; biomechanical evaluation and preliminary cell seeding, Journal of the Mechanical Behavior of Biomedical Materials, 14, 2012, p130-142Journal Article, 2012
Redmond, E.M., Lally, C., Cahill, P.A., Hemodynamic control of vascular smooth muscle function, Muscle, 2, 2012, p1231-1242Journal Article, 2012
Zahedmanesh, H., Lally, C., A multiscale mechanobiological modelling framework using agent-based models and finite element analysis: Application to vascular tissue engineering, Biomechanics and Modeling in Mechanobiology, 11, (3-4), 2012, p363-377Journal Article, 2012
Guha, S., Cullen, J.P., Morrow, D., Colombo, A., Lally, C., Walls, D., Redmond, E.M., Cahill, P.A., Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: Role in cell proliferation and survival, Basic Research in Cardiology, 106, (5), 2011, p773-785Journal Article, 2011
Zahedmanesh, H., MacKle, J.N., Sellborn, A., Drotz, K., Bodin, A., Gatenholm, P., Lally, C., Bacterial cellulose as a potential vascular graft: Mechanical characterization and constitutive model development, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 97 B, (1), 2011, p105-113Journal Article, 2011
Colombo, A., Zahedmanesh, H., Toner, D.M., Cahill, P.A., Lally, C., A method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments, Journal of the Mechanical Behavior of Biomedical Materials, 3, (6), 2010, p470-477Journal Article, 2010
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Patient specific finite element modelling of the carotid bifurcation, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p529-530Journal Article, 2009
Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C., Kelly, D.J., Mechanical characterization of fresh human carotid atherosclerotic plaque, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART B), 2009, p1307-1308Journal Article, 2009
Zahedmanesh, H., Lally, C., Determination of the influence of stent strut thickness using the finite element method: Implications for vascular injury and in-stent restenosis, Medical and Biological Engineering and Computing, 47, (4), 2009, p385-393Journal Article, 2009
Zahedmanesh, H., Gatenholm, P., Lally, C., Bacterial cellulose: A potential vascular graft and tissue engineering scaffold, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p519-520Journal Article, 2009
Flamini, V., Kerskens, C., Lally, C., An anisotropic structural model of the aortic wall based on tensile tests and non-invasive 3D fibre analysis using diffusion tensor imaging, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p411-412Journal Article, 2009
Lally, C., Sellborn, A., Bodin, A., Bäckdahl, H., Gatenholm, P., Risberg, B., Mechanical characterization of bacterial cellulose tubes for vascular tissue engineering, 8th World Biomaterials Congress 2008, 2, 2008Journal Article, 2008
Colombo, A., Cahill, P.A., Lally, C., An analysis of the strain field in biaxial Flexcell membranes for different waveforms and frequencies, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 222, (8), 2008, p1235-1245Journal Article, 2008
Lally, C., Dolan, F., Prendergast, P.J., Erratum to "Cardiovascular stent design and vessel stresses: A finite element analysis". [Journal of Biomechanics 38 (2005) 1574-1581] (DOI:10.1016/j.jbiomech.2004.07.022), Journal of Biomechanics, 39, (9), 2006Journal Article, 2006
David Nolan, Caitriona Lally, A Mechanobiological Framework for the Prediction of In-Stent Restenosis; Insights into the role of load induced damage in restenotic growth, The Virtual Physiological Human Conference, Amsterdam, 26/09/2016, edited by Alfons Hoekstra , 2016Conference Paper, 2016, TARA - Full Text
Robert Gaul, Thomas Sinnott, Caitriona Lally, The automated characterisation of collagen fibre orientation in arteries using small angle light scattering, UK Society for Biomaterials, Belfast, Ireland, 2015Poster, 2015, TARA - Full Text
Syed Salman Shahid, Christian Kerskens, Robert Gaul, Vittoria Flamini, Caitriona Lally, Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging, European Society for Magnetic Resonance in Medicine and Biology , Vienna, Austria, 29-09-2017, 2016Poster, 2016, TARA - Full Text
Shahid, Syed Salman, Christian, Kerskens, Caitriona, Lally, Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall, Bioengineering in Ireland, Belfast, 20-10-2017, 2017Oral Presentation, 2017, TARA - Full Text
Syed salman Shahid, Christian Kerskens, Robert Gaul, Caitriona Lally, Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging, European Molecular Imaging Meeting, Germany, 5-04-2017, 2017Poster, 2017, TARA - Full Text
David R. Nolan, Caitríona Lally, An Investigation of Damage Mechanisms in Mechanobiological Models of In-Stent Restenosis, Journal of Computational Science, 2017Journal Article, 2017, URL , TARA - Full Text
David Nolan; Caitríona Lally, An in-silico investigation into the influence of endothelial denudation on the progression on in-stent restenosis, European Society of Biomechanics, Seville, 2017Meeting Abstract, 2017, TARA - Full Text
David Nolan, Assessment of a Clinically Relevant Geometric Measure for Identifying Vulnerable Carotid Plaques, Bioengineering in Ireland, Belfast, 2017Meeting Abstract, 2017, TARA - Full Text
Robert Gaul, Caitriona Lally, Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design, Summer Biomechanics, Bioengineering and Biotransport Conference 2017, Arizona, USA, June 2017, 2017Oral Presentation, 2017, TARA - Full Text
Robert Gaul, David Nolan, Caitriona Lally, Collagen fibre characterisation in arterial tissue under load using SALS, Journal of the Mechanical Behavior of Biomedical Materials, 75, 2017, p359 - 368Journal Article, 2017, URL , TARA - Full Text
Syed Salman Shahid, Robert Gaul, Christian Kerskens, Vittoria Flamini, Caitriona Lally, Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging - Comparison of intact vs. open cut tissue , Physics in Medicine and Biology, 62, (23), 2017, p8850 - 8868Journal Article, 2017, URL , TARA - Full Text
Coupled Finite Element-Agent Based Models for the Simulation of Vascular Growth and Remodeling in, editor(s)Miguel Cerrolaza Sandra J. Shefelbine Diego Garzon-Alvarado , Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes, Elsevier, 2017, pp283 - 298, [David Nolan, Caitriona Lally]Book Chapter, 2017
Lally, C, Reid, AJ, Prendergast, PJ, Elastic behaviour of porcine coronary arteries under uniaxial and equibiaxial tension, Annals of Biomedical Engineering, 32, 2004, p1355 - 1364Journal Article, 2004
Robert Gaul, David Nolan, Tomasso Ristori, Carlijn Bouten, Sandra Loerakker, Caitriona Lally, Strain Mediated Arterial Degradation is Critically Influenced by Matrix Content and Collagen Crimp, Proceedings of the 24th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Meath, Ireland, 2018Oral Presentation, 2018, TARA - Full Text
Milad Ghasemi, David Nolan, Caitríona Lally , An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development, Biomechanics and Modeling in Mechanobiology, 2018Journal Article, 2018, DOI , URL , TARA - Full Text
Robert Gaul, David Nolan, Tomasso Ristori, Carlijn Bouten, Sandra Loerakker, Caitriona Lally, Strain mediated Enzymatic Degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp, Acta Biomaterialia, 2018Journal Article, 2018, DOI , TARA - Full Text
Robert Gaul, David Nolan, Tomasso Ristori, Carlijn Bouten, Sandra Loerakker, Caitriona Lally, Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp, 8th World Congress of Biomechanics, Dublin, Ireland, 8-12 July, 2018Oral Presentation, 2018, TARA - Full Text
Robert Gaul, David Nolan, Caitríona Lally, The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo , Journal of Biomechanics, 2018Journal Article, 2018, TARA - Full Text
Alix Whelan, Duffy J., Gaul R.T., O'Reilly D., Nolan D.R., Gunning P., Lally C., Murphy B.P., Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium, Journal of the Mechanical Behavior of Biomedical Materials, 90, 2019, p54 - 60Journal Article, 2019, TARA - Full Text
Clarkin O.M., Wu B., Cahill P.A., Brougham D.F., Banerjee D., Brady S.A., Fox E.K., Lally C., Novel injectable gallium-based self-setting glass-alginate hydrogel composite for cardiovascular tissue engineering, Carbohydrate Polymers, 217, 2019, p152 - 159, p152-159Journal Article, 2019, DOI
Schipani, R. and Nolan, D.R. and Lally, C. and Kelly, D.J., Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering, Connective Tissue Research, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
Ghasemi M., Nolan D.R., Lally C., Assessment of mechanical indicators of carotid plaque vulnerability: Geometrical curvature metric, plaque stresses and damage in tissue fibres, Journal of the Mechanical Behavior of Biomedical Materials, 103, 2020Journal Article, 2020, DOI
Mathieu P.S., Fitzpatrick E., Di Luca M., Cahill P.A., Lally C., Resident multipotent vascular stem cells exhibit amplitude dependent strain avoidance similar to that of vascular smooth muscle cells, Biochemical and Biophysical Research Communications, 521, (3), 2020, p762 - 768, p762-768Journal Article, 2020, DOI
Alix Whelan, Elizabeth Williams, David Nolan, Bruce Murphy, Paul Gunning, David O'Reilly, Caitríona Lally, Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue, Annals of Biomedical Engineering, 49, (3), 2021, p1022 - 1032Journal Article, 2021, DOI , TARA - Full Text
Brooke Tornifoglio, Alan J. Stone, Robert D. Johnston, Salmon S. Shahid, Christian Kerskens, Caitriona Lally, Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography, Scientific Reports, 2020Journal Article, 2020, TARA - Full Text
Greg Campion, Kylie Hershberger, Alix Whelan, Jack Conroy, Caitr ona Lally & Bruce P. Murphy, A Biomechanical and Microstructural Analysis of Bovine and Porcine Pericardium for Use in Bioprosthetic Heart Valves, Structural Heart, 5, (5), 2021, p486 - 496Journal Article, 2021, DOI , TARA - Full Text
Alan J. Stone, Brooke Tornifoglio, Robert D. Johnston, Karin Shmueli, Christian Kerskens, Caitríona Lally, Quantitative susceptibility mapping of carotid arterial tissue ex vivo: assessing sensitivity to vessel microstructural composition, Magnetic Resonance in Medicine, 86, 2021, p2512 - 2527Journal Article, 2021, DOI
, Fibre orientation of fresh and frozen porcine aorta determined non-invasively using diffusion tensor imaging, Med Eng Phys, 2013Journal Article, 2013, DOI
Tornifoglio B., Johnston R.D., Stone A.J., Kerskens C., Lally C., Microstructural and mechanical insight into atherosclerotic plaques: an ex vivo DTI study to better assess plaque vulnerability, Biomechanics and Modeling in Mechanobiology, 2023Journal Article, 2023, DOI , TARA - Full Text
Tornifoglio B., Stone A.J., Kerskens C., Lally C., Ex Vivo Study Using Diffusion Tensor Imaging to Identify Biomarkers of Atherosclerotic Disease in Human Cadaveric Carotid Arteries, Arteriosclerosis, Thrombosis, and Vascular Biology, 42, (11), 2022, p1398 - 1412, p1398-1412Journal Article, 2022, DOI , TARA - Full Text
Johnston, Robert D., Ghasemi, Milad, Lally, Caitríona, Inverse material parameter estimation of patient"specific finite element models at the carotid bifurcation: The impact of excluding the zero"pressure configuration and residual stress, International Journal for Numerical Methods in Biomedical Engineering, 39, (1), 2023Journal Article, 2023, DOI , TARA - Full Text
Alix Whelan, Gordon O'Brien, Anna Szagdaj, David O'Reilly, Catríona Lally, Investigation into early stage fatigue-damage accumulation in glutaraldehyde-fixed bovine pericardium using a novel equibiaxial bulge inflation system, Journal of the Mechanical Behavior of Biomedical Materials, 121, 2021Journal Article, 2021, URL
B Tornifoglio, A. J. Stone, P. Mathieu, E. Fitzpatrick, C. Kerskens, C. Lally, Exploring DTI-derived metrics to non-invasively track recellularisation in vascular tissue engineering, 2022Journal Article, 2022, DOI
E. Fitzpatrick, R. Gaul, C. Smekens, P. Mathieu, B. Meehan, B. Tornifoglio, P.A. Cahill, C. Lally, A short-term decellularisation technique for porcine carotid arteries that conveys a structural stimulus to cells, 2022Journal Article, 2022, DOI
Ruth E. Levey, Brooke Tornifoglio, Alan J. Stone, Christian Kerskens, Scott T. Robinson, Fergal B. Coulter, Robert Bagnall, Raymond O"Connor, Eimear B. Dolan, Peter Dockery, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Paul Johnson, Eoin O"Cearbhaill, Caitríona Lally, Garry P. Duffy, Towards a Whole Sample Imaging Approach Using Diffusion Tensor Imaging to Examine the Foreign Body Response to Explanted Medical Devices, Polymers, 2022Journal Article, 2022, DOI
Brooke Tornifoglio, Alan J. Stone, Pattie Mathieu, Emma Fitzpatrick, Christian Kerskens, Caitriona Lally, Measuring Vascular Graft Cellularity Non-Destructively: Merging Magnetic Resonance Imaging and Tissue Engineering, Advanced Materials Technologies, 2023Journal Article, 2023
Shahid SS, Johnston RD, Smekens C, Kerskens C, Gaul R, Tornifoglio B, Stone AJ, Lally C, Exploring arterial tissue microstructural organization using non-Gaussian diffusion magnetic resonance schemes., Scientific reports, 2021Journal Article, 2021, DOI
Angelica S Federici, Brooke Tornifoglio, Caitríona Lally, Orquidea Garcia, Daniel J Kelly, David A Hoey, Melt electrowritten scaffold architectures to mimic tissue mechanics and guide neo-tissue orientation, Journal of the Mechanical Behavior of Biomedical Materials, 150, 2024, p1 - 15Journal Article, 2024, DOI , TARA - Full Text
Matthew Laffey, Brooke Tornifoglio, Caitríona Lally, Development and Initial Characterisation of a Localised Elastin Degradation Ex Vivo Porcine Aortic Aneurysm Model, Applied Sciences, 13, (17), 2023Journal Article, 2023
Alice Hanly, Robert D Johnston, Claire Lemass, Ann Jose, Brooke Tornifoglio, Caitriona Lally, Phosphotungstic acid (PTA) preferentially binds to collagen- rich regions of porcine carotid arteries and human atherosclerotic plaques observed using contrast enhanced micro-computed tomography (CE-µCT), Frontiers in Physiology, 14, 2023Journal Article, 2023
O'Keeffe, C. and Taylor, D. and Lally, C. and Kelly, D.J., Morphological induced improvements in the bulk mechanical properties of chemically etched additively manufactured Ti-6Al-4V micro-struts, Additive Manufacturing, 75, (103748), 2023Journal Article, 2023, DOI
Brady, S.A., Fox, E.K., Laffir, F.R., Phelan, B., O"Hare, A., Lally, C., Clarkin, O.M., Surface modification of a novel glass to optimise strength and deliverability of an injectable alginate composite, Journal of Materials Science, 52, (24), 2017, p13700-13710Journal Article, 2017, DOI
Redmond, E.M., Lally, C., Cahill, P.A., Common Pathways in Cancer, Tumor Angiogenesis and Vascular Disease, Cardio-Oncology: Principles, Prevention and Management, 2016, p25-34Journal Article, 2016, DOI
Liu, Y., Zahedmanesh, H., Lally, C., Cahill, P.A., McGuinness, G.B., Compliance properties of a composite electrospun fibre - Hydrogel blood vessel scaffold, Materials Letters, 178, 2016, p296-299Journal Article, 2016, DOI
Zahedmanesh, H., Lally, C., Multiscale Modeling in Vascular Disease and Tissue Engineering, Studies in Mechanobiology, Tissue Engineering and Biomaterials, 14, 2013, p241-258Journal Article, 2013, DOI
Pierrat, B., Carroll, L., Merle, F., MacManus, D.B., Gaul, R., Lally, C., Gilchrist, M.D., Ní Annaidh, A., Mechanical Characterization and Modeling of the Porcine Cerebral Meninges, Frontiers in Bioengineering and Biotechnology, 8, 2020Journal Article, 2020, DOI
Gaul, R.T., Nolan, D.R., Ristori, T., Bouten, C.V.C., Loerakker, S., Lally, C., Pressure-induced collagen degradation in arterial tissue as a potential mechanism for degenerative arterial disease progression, Journal of the Mechanical Behavior of Biomedical Materials, 109, 2020Journal Article, 2020, DOI
Nolan, D.R., Lally, C., An investigation of damage mechanisms in mechanobiological models of in-stent restenosis, Journal of Computational Science, 24, 2018, p132-142Journal Article, 2018, DOI
Galvin, E., O'Brien, D., Cummins, C., Mac Donald, B.J., Lally, C., A strain-mediated corrosion model for bioabsorbable metallic stents, Acta Biomaterialia, 55, 2017, p505-517Journal Article, 2017, DOI
Brady, S.A., Fox, E.K., Lally, C., Clarkin, O.M., Optimisation of a novel glass-alginate hydrogel for the treatment of intracranial aneurysms, Carbohydrate Polymers, 176, 2017, p227-235Journal Article, 2017, DOI
Galvin, E., Cummins, C., Yoshihara, S., Mac Donald, B.J., Lally, C., Plastic strains during stent deployment have a critical influence on the rate of corrosion in absorbable magnesium stents, Medical and Biological Engineering and Computing, 55, (8), 2017, p1261-1275Journal Article, 2017, DOI
Bose S., Akbarzadeh Khorshidi M., Johnston R.D., Watschke B., Mareena E., Lally C., Experimental testing combined with inverse-FE for mechanical characterisation of penile tissues, Acta Biomaterialia, 179, 2024, p180 - 191, p180-191Journal Article, 2024, DOI
O'Keeffe C., Kotlarz M., Goncalves I.F., Lally C., Kelly D.J., Chemical etching of Ti-6Al-4V biomaterials fabricated by selective laser melting enhances mesenchymal stromal cell mineralization, Journal of Biomedical Materials Research - Part A, 2024Journal Article, 2024, DOI , TARA - Full Text
Federici, A.S., Tornifoglio, B., Lally, C., Garcia, O., Kelly, D.J., Hoey, D.A., Melt electrowritten scaffold architectures to mimic vasculature mechanics and control neo-tissue orientation, bioRxiv, 2023Journal Article, 2023, DOI
Lally, C, Dolan, F, Prendergast, PJ, Cardiovascular stent design and blood vessel stress: a finite element analysis, Journal of Biomechanics, 38, (8), 2005, p1574 - 1581Journal Article, 2005, DOI , URL
Hughes, C., Whelan, A., O"Reilly, D., Campbell, E., Lally, C., Aortic Valve Leaflet Assessment: Understanding the Impact of Collagen Microstructure on Leaflet Mechanical Behaviour, SSRN, 2024Journal Article, 2024, DOI
Khorshidi, M.A., Bose, S., Watschke, B., Mareena, E., Lally, C., Characterisation of Human Penile Tissue Properties Using Experimental Testing Combined with Multi-Target Inverse Finite Element Modelling, SSRN, 2024Journal Article, 2024, DOI
Akbarzadeh Khorshidi, M., Bose, S., Watschke, B., Mareena, E., Lally, C., Characterisation of human penile tissue properties using experimental testing combined with multi-target inverse finite element modelling, Acta Biomaterialia, 2024Journal Article, 2024, DOI
O"Keeffe, C., Zhang, W., Johnston, R.D., Promoppatum, P., Taylor, D., Lally, C., Kelly, D.J., Feature Size Specific Processing Parameters for Additively Manufactured Ti-6al-4v Micro-Strut Lattices, SSRN, 2024Journal Article, 2024, DOI , TARA - Full Text
Guendouz, Y., Razif, N.A.M., Bernasconi, F., O"Brien, G., Johnston, R.D., Lally, C., Inverse Finite Element Framework Combining Ultrasound Imaging and Inflation Testing of PVA Artery Phantoms, bioRxiv, 2024Journal Article, 2024, DOI
Bose, S., Khorshidi, M.A., Lally, C., Tailoring the Mechanical Properties of Macro-Porous PVA Hydrogels for Biomedical Applications, SSRN, 2024Journal Article, 2024, DOI
Fereidoonnezhad, B., Akbarzadeh Khorshidi, M., Bose, S., Watschke, B., Mareena, E., Nolan, D., Cooney, S., Lally, C., Development of in silico models to guide the experimental characterisation of penile tissue and inform surgical treatment of erectile dysfunction, Computers in Biology and Medicine, 166, 2023Journal Article, 2023, DOI
van Asten, J.G.M., Ristori, T., Nolan, D.R., Lally, C., Baaijens, F.P.T., Sahlgren, C.M., Loerakker, S., Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension, Journal of the Mechanical Behavior of Biomedical Materials, 133, 2022Journal Article, 2022, DOI
Mathieu, P.S., Fitzpatrick, E., Di Luca, M., Cahill, P.A., Lally, C., Native extracellular matrix orientation determines multipotent vascular stem cell proliferation in response to cyclic uniaxial tensile strain and simulated stent indentation, Biochemistry and Biophysics Reports, 29, 2022Journal Article, 2022, DOI
Hanly, A., Johnston, R.D., Lemass, C., Jose, A., Tornifoglio, B., Lally, C., Phosphotungstic acid (PTA) preferentially binds to collagen-rich regions of porcine carotid arteries and human atherosclerotic plaques using 3D micro-computed tomography (CE-µCT), bioRxiv, 2022Journal Article, 2022, DOI
Bose, S., Fereidoonnezhad, B., Khorshidi, M.A., Watschke, B., Mareena, E., Nolan, D., Cooney, S., Cullen, I.M., Lally, C., The role of tissue biomechanics in the implantation and performance of inflatable penile prostheses: current state of the art and future perspective, Sexual Medicine Reviews, 11, (3), 2023, p268-277Journal Article, 2023, DOI
McGee, O.M., Geraghty, S., Hughes, C., Jamshidi, P., Kenny, D.P., Attallah, M.M., Lally, C., An investigation into patient-specific 3D printed titanium stents and the use of etching to overcome Selective Laser Melting design constraints, Journal of the Mechanical Behavior of Biomedical Materials, 134, 2022Journal Article, 2022, DOI
Galvin, E., Jaiswal, S., Lally, C., MacDonald, B., Duffy, B., In vitro corrosion and biological assessment of bioabsorbable WE43 mg alloy specimens, Journal of Manufacturing and Materials Processing, 1, (1), 2017Journal Article, 2017, DOI
Mathieu, P.S., Fitzpatrick, E., Di Luca, M., Cahill, P.A., Lally, C., Native extracellular matrix orientation determines multipotent vascular stem cell proliferation in response to cyclic uniaxial tensile strain and simulated stent indentation, bioRxiv, 2020Journal Article, 2020, DOI
Luca, M.D., Fitzpatrick, E., Burtenshaw, D., Liu, W., Helt, J.-C., Hakimjavadi, R., Corcoran, E., Gusti, Y., Sheridan, D., Harman, S., Lally, C., Redmond, E.M., Cahill, P.A., The Calcium Binding Protein S100ß Marks Hedgehog-Responsive Perivascular Stem Cells That Contribute to Intimal Thickening following Iatrogenic Flow Restriction, SSRN, 2020Journal Article, 2020, DOI
McGuinness, G.B., Pascu, I., Lally, C., O"connor, R., Scaffold Processing Technologies for Tailored Cell Interactions, Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies, 2018, p15-50Journal Article, 2018
Nolan, D.R., Lally, C., McGarry, J.P., Understanding the deformation gradient in Abaqus and key guidelines for anisotropic hyperelastic user material subroutines (UMATs), Journal of the Mechanical Behavior of Biomedical Materials, 126, 2022Journal Article, 2022, DOI
McGee, O.M., Nolan, D.R., Mathieu, P.S., Lally, C., An in-silico Investigation Into the Role of Strain and Structure on Vascular Smooth Muscle Cell Growth, Frontiers in Bioengineering and Biotechnology, 9, 2021Journal Article, 2021, DOI
McGee, O.M., Geraghty, S., Hughes, C., Jamshidi, P., Kenny, D.P., Attallah, M.M., Lally, C., An investigation into patient-specific 3D printed titanium stents and the use of etching to overcome selective laser melting design constraints, bioRxiv, 2021Journal Article, 2021, DOI
Johnston, R.D., Gaul, R.T., Lally, C., An investigation into the critical role of fibre orientation in the ultimate tensile strength and stiffness of human carotid plaque caps, Acta Biomaterialia, 124, 2021, p291-300Journal Article, 2021, DOI
Whelan, A., Williams, E., Fitzpatrick, E., Murphy, B.P., Gunning, P.S., O'Reilly, D., Lally, C., Collagen fibre-mediated mechanical damage increases calcification of bovine pericardium for use in bioprosthetic heart valves, Acta Biomaterialia, 128, 2021, p384-392Journal Article, 2021, DOI
Ghasemi, M., Johnston, R.D., Lally, C., Development of a Collagen Fibre Remodelling Rupture Risk Metric for Potentially Vulnerable Carotid Artery Atherosclerotic Plaques, Frontiers in Physiology, 12, 2021Journal Article, 2021, DOI
Di Luca, M., Fitzpatrick, E., Burtenshaw, D., Liu, W., Helt, J.-C., Hakimjavadi, R., Corcoran, E., Gusti, Y., Sheridan, D., Harman, S., Lally, C., Redmond, E.M., Cahill, P.A., The calcium binding protein S100ß marks hedgehog-responsive resident vascular stem cells within vascular lesions, npj Regenerative Medicine, 6, (1), 2021Journal Article, 2021, DOI
Johnston, R.D., Gaul, R.T., Lally, C., An investigation into the critical role of fibre orientation in the ultimate tensile strength and stiffness of human carotid plaque caps, bioRxiv, 2020Journal Article, 2020, DOI
Whelan, A., Williams, E., Fitzpatrick, E., Murphy, B., Gunning, P.S., O"Reilly, D., Lally, C., Collagen fibre-mediated mechanical damage increases calcification of bovine pericardium for use in bioprosthetic heart valves, bioRxiv, 2020Journal Article, 2020, DOI
Prendergast, PJ, Lally, C, Daly, S, Lee, TC, Quinn, D, Dolan, F, Analysis of prolapse in cardiovascular stents: a constitutive equation for vascular tissue and finite element modelling, Journal of Biomechanical Engineering , 125, 2003, p692-699Journal Article, 2003
Pericevic, I., Lally, C., Toner, D., Kelly, D.J. , The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents, Medical Engineering and Physics , 31, (4), 2009, p428-433Journal Article, 2009, DOI , URL , TARA - Full Text
Vittoria Flamini, Christian Kerskens, Kevin Mattheus Moerman, Ciaran Simms and Caitríona Lally , Imaging Arterial Fibres Using Diffusion Tensor Imaging-Feasibility Study and Preliminary Results, EURASIP Journal on Advances in Signal Processing, 2010, (904091), 2010Journal Article, 2010, DOI , URL , TARA - Full Text
Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. , Tensile and compressive properties of fresh human carotid atherosclerotic plaques. , Journal of Biomechanics, 42, (16), 2009, p2760-2767Journal Article, 2009, DOI , TARA - Full Text
Prendergast, P.J., Lally, C., Lennon, A.B., Finite element modelling of medical devices , Medical Engineering and Physics, 31, (4), 2009, 419Journal Article, 2009, DOI
Moerman, KM ; Kerskens, CM ; Lally, C ; Flamini, V ; Simms, CK , Evaluation of a Validation Method for MR Imaging-Based Motion Tracking Using Image Simulation, EURASIP Journal on Advances in Signal Processing, 2010, 2010, p942131Journal Article, 2010, DOI , TARA - Full Text
Michael Early; Catriona Lally; Patrick J. Prendergast; Daniel J. Kelly, Stresses in peripheral arteries following stent placement: a finite element analysis, Computer Methods in Biomechanics and Biomedical Engineering, 12, (1), 2009, p25 - 33Journal Article, 2009, DOI , URL , TARA - Full Text
Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents., Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, (1921), 2010, p2919-35Journal Article, 2010, DOI , URL , TARA - Full Text
Flamini V, Kerskens C, Moerman K, Simms C and Lally C, Imaging arterial fibres using diffusion tensor imaging - feasibility study & preliminary results, EURASIP Journal on Advances in Signal Processing, 2010, 2010, pArticle ID 904091Journal Article, 2010, DOI , TARA - Full Text
Boyle, C.J., Lally, C., Prendergast, P.J, Injury driven biological model of restenotic lesion development predicts the effects of stent geometry on restenosis, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, 11th ASME Summer Bioengineering Conference, SBC2009, Lake Tahoe, edited by 17-21 June , PART B, ASME, 2009, pp1055-1056Conference Paper, 2009
Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J., Inelasticity of Human Carotid Atherosclerotic Plaque. , Annals of Biomedical Engineering, 39, (9), 2011, p2445-2455Journal Article, 2011, DOI
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Nagel, T., Kelly, D.J., Prediction of fibre architecture and adaptation in diseased carotid bifurcations. , Biomechanics and Modeling in Mechanobiology , 10, (6), 2011, p831-843Journal Article, 2011, DOI
Zahedmanesh, H., Kelly, D.J., Lally, C. , Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy, Journal of Biomechanics, 43, (11), 2010, p2126-2132Journal Article, 2010, DOI
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. , Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography., Computers in Biology and Medicine, 40, (4), 2010, p419-429Journal Article, 2010, DOI
Eoghan Maher, Arthur Creane, Caitríona Lally, Daniel J. Kelly, An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue, Journal of the Mechanical Behavior of Biomedical Materials, 12, 2012, p9-19Journal Article, 2012, DOI , URL , TARA - Full Text
Maher E, Early M, Creane A, Lally C, Kelly DJ, Site specific inelasticity of arterial tissue., Journal of biomechanics, 45, (8), 2012, p1393-1399Journal Article, 2012, DOI , TARA - Full Text
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations., Biomechanics and Modeling in Mechanobiology, 11, (6), 2012, p869-882Journal Article, 2012, DOI
Flamini V, Kerskens C, Moerman K, Simms CK and Lally C, Fibre orientation of fresh and frozen porcine aorta determined non-invasively, Medical Engineering and Physics, 35, (6), 2013, 765-776Journal Article, 2013, DOI
Patient Specific Computational Modeling in Cardiovascular Mechanics in, Patient-Specific Computational Modeling, 2012, pp61-79 , [A Creane, DJ Kelly, C Lally. ]Book Chapter, 2012, DOI
Colombo, A., Guha, S., Mackle, J.N., Cahill, P.A., Lally, C., Cyclic strain amplitude dictates the growth response of vascular smooth muscle cells in vitro: Role in in-stent restenosis and inhibition with a sirolimus drug-eluting stent, Biomechanics and Modeling in Mechanobiology, 12, (4), 2013, p671-683Journal Article, 2013, DOI
Galvin, E., Morshed, M.M., Cummins, C., Daniels, S., Lally, C., MacDonald, B., Surface modification of absorbable magnesium stents by reactive ion etching, Plasma Chemistry and Plasma Processing, 33, (6), 2013, p1137-1152Journal Article, 2013, DOI

Robert Gaul, Caitriona Lally, Strain mediated enzyme degradation of arterial tissue characterised by small angle light scattering, Proceedings of the 23rd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland., Belfast, Ireland, 2017Oral Presentation, TARA - Full Text
Robert Gaul, Caitriona Lally, Load induced changes in collagen fibre architecture in arteries characterised by small angle light scattering, Proceedings of the 22nd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2016Oral Presentation, TARA - Full Text
Robert Gaul, Caitriona Lally, The use of small angle light scattering for the characterisation of collagen fibre orientation in arteries, Proceedings of the 21st Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Kildare, Ireland, 2015Oral Presentation, TARA - Full Text
Alix Whelan, Robert Gaul, Paul Gunning, Caitriona Lally, Investigation of Collagen Fibre Orientation in Bovine Pericardium, Proceedings of the 23rd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Belfast, 20/01/17, 2017Oral Presentation, TARA - Full Text
Simulation of in-stent restenosis for the design of cardiovascular stents in, G. Holzpafel & R. Ogden , Mechanics of Biological Tissue, Springer, 2006, pp255 - 267, [Lally, C, Prendergast, PJ]Book Chapter

Research Expertise

Keywords

Cardiovascular medicine and haematology, Medical and biomedical engineering, Condensed matter physics,

Recognition

Career Start Grant (DCU) 2005
ERC PoC grant 2021
Royal Society of Medicine in Ireland, 1st prize for best student paper 2004
Senior author on research paper which was awarded 2nd prize for the Engineers Ireland - IMECHE Young Engineers Research Award 2012
Royal Society of Medicine in Ireland, 2nd prize for best student paper 2002
ERC Starting Grant 2014
Bernard Crossland Symposium, 2nd prize for best student paper 2002
Sylvestor O'Halloran Surgical Meeting, 1st prize in poster presentation 2002

Member of the Institution of Engineers of Ireland (MIEI) Present
PI in the Trinity Centre for Biomedical Engineering Present
PI in the SFI AMBER Centre Present
Member of the committee for the Biomedical Division of the Institute of Engineers of Ireland 2009
Member of the European Society of Biomechanics present
Member of the Royal Academy of Medicine of Ireland (RAMI) and President of the Bioengineering section (2023-) Present

Research Committee Member
Research Committee Member