Professor Daniel J Kelly

• Cunniffe, G.M., Vinardell, T., Murphy, J.M., (...), O'Brien, F.J., Kelly, D.J., Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing, Acta Biomaterialia, 23, 2015, p82-90Journal Article, 2015, DOI , TARA - Full Text
• Sridharan, R., Cameron, A.R., Kelly, D.J., Kearney, C.J., O'Brien, F.J., Biomaterial based modulation of macrophage polarization: A review and suggested design principles, Materials Today, 18, (6), 2015, 313-325Journal Article, 2015, DOI , TARA - Full Text
• Gannon, A.R., Nagel, T., Bell, A.P., Avery, N.C., Kelly, D.J., The changing role of the superficial region in determining the dynamic compressive properties of articular cartilage during postnatal development, Osteoarthritis and Cartilage, 23, (6), 2015, p975-984Journal Article, 2015, DOI
• Luo L., Thorpe S.D., Buckley C.T. and Kelly D.J. , The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells, Biomedical Materials, 21, (10(5)), 2015, p055011Journal Article, 2015, DOI
• Mesallati T., Buckley C.T. and Kelly D.J. , Engineering cartilaginous grafts using chondrocyte-laden hydrogels supported by a superficial layer of stem cells, Journal of Tissue Engineering and Regenerative Medicine , 5, (18), 2016, p2353-2362Journal Article, 2016, DOI
• Sheehy E.J., Mesallati T., Vinardell T., Kelly L., Buckley C.T. and Kelly D.J., Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx, BioResearch, 4, (1), 2015, p229 - 241Journal Article, 2015, DOI , TARA - Full Text
• Burke D, Kelly D.J, A mechanobiological model of endothelial cell migration and proliferation, Computer Methods in Biomechanics and Biomedical Engineering, 19, (1), 2016, p74 - 83Journal Article, 2016, DOI , URL
• Mesallati T, Sheehy E.J, Vinardell T, Buckley C.T, Kelly D.J, Tissue engineering scaled-up, anatomically shaped osteochondral constructs for joint resurfacing, European Cells and Materials, 30, 2015, p163 - 186Journal Article, 2015, URL , TARA - Full Text
• Cunniffe G.M, Vinardell T, Thompson E.M, Daly A.C, Matsiko A, O'Brien F.J, Kelly D.J, Chondrogenically primed mesenchymal stem cell-seeded alginate hydrogels promote early bone formation in critically-sized defects, European Polymer Journal, 72, 2015, p464 - 472Journal Article, 2015, DOI , URL
• Luo L, Eswaramoorthy R, Mulhall K.J, Kelly D.J, Decellularization of porcine articular cartilage explants and their subsequent repopulation with human chondroprogenitor cells, Journal of the Mechanical Behavior of Biomedical Materials, 55, 2015, p21 - 31Journal Article, 2015, DOI , URL
• Olvera D, Daly A, Kelly D.J, Mechanical testing of cartilage constructs, Methods in Molecular Biology, 1340, 2015, p279-287Journal Article, 2015, DOI , URL
• Broderick J.M, Kelly D.J, Mulhall K.J, Optimizing stem cell engineering for orthopaedic applications, Journal of the American Academy of Orthopaedic Surgeons, 22, (1), 2014, p63 - 65Journal Article, 2014, DOI , URL
• Nagel T, Kelly D.J, The composition of engineered cartilage at the time of implantation determines the likelihood of regenerating tissue with a normal collagen architecture, Tissue Engineering - Part A, 19, (7-8), 2013, p824 - 833Journal Article, 2013, DOI , URL
• Cummins F, Reilly P.O', Flannery O, Kelly D, Kenny P, Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty, Acta Orthopaedica, 82, (4), 2011, p433 - 437Journal Article, 2011, DOI , URL
• Boccaccio A, Kelly D.J, Pappalettere C, A mechano-regulation model of fracture repair in vertebral bodies, Journal of Orthopaedic Research, 29, (3), 2011, p433 - 443Journal Article, 2011, DOI , URL
• Nagel T, Kelly D.J, The influence of fiber orientation on the equilibrium properties of neutral and charged biphasic tissues., Journal of biomechanical engineering, 132, (11), 2010, p114506-Journal Article, 2010, URL
• Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Patient specific finite element modelling of the carotid bifurcation, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p529-530Journal Article, 2009
• Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C., Kelly, D.J., Mechanical characterization of fresh human carotid atherosclerotic plaque, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART B), 2009, p1307-1308Journal Article, 2009
• O'Reilly, A., Kelly, D.J., Role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects, Journal of Orthopaedic Research, 34, (6), 2015, p1026-36Journal Article, 2015, DOI
• Kasiri, S., Kelly, D.J., An argument for the use of multiple segment stents in curved arteries, Journal of Biomechanical Engineering, 133, (8), 2011Journal Article, 2011
• Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., A comparative study of shear stresses in collagen-glycosaminoglycan and calcium phosphate scaffolds in bone tissue-engineering bioreactors, Tissue Engineering - Part A, 15, (5), 2009, p1141-1149Journal Article, 2009
• Byrne, D.P., Lacroix, D., Planell, J.A., Kelly, D.J., Prendergast, P.J., Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: Application of mechanobiological models in tissue engineering, Biomaterials, 28, (36), 2007, p5544-5554Journal Article, 2007
• Guerin, S.R., MacNiochaill, R., O'Reilly, P., O'Byrne, J., Kelly, D.J., A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface, Bio-Medical Materials and Engineering, 17, (6), 2007, p379-386Journal Article, 2007
• Crawford, A., Kelly, D.J., Dickinson, S.C., Sims, T.J., Mundy, J., Hollander, A.P., Prendergast, P.J., Hatton, P.V., Matrix proteins as predictive markers of the mechanical strength of engineered cartilage, European Cells and Materials, 11, (SUPPL.2), 2006Journal Article, 2006
• Daly, A.C., Cunniffe, G.M., Sathy, B.N., Jeon, O., Alsberg, E., Kelly, D.J., 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering, Advanced Healthcare Materials, 5, (18), 2016, p2353-2362Journal Article, 2016, DOI , TARA - Full Text
• OReilly, A., Hankenson, K.D., Kelly, D.J., A computational model to explore the role of angiogenic impairment on endochondral ossification during fracture healing, Biomechanics and Modeling in Mechanobiology, 15, 2016, p1279-1294Journal Article, 2016, DOI , TARA - Full Text
• Thompson, E.M., Matsiko, A., Kelly, D.J., Gleeson, J.P., O'Brien, F.J., An Endochondral Ossification-Based Approach to Bone Repair: Chondrogenically Primed Mesenchymal Stem Cell-Laden Scaffolds Support Greater Repair of Critical-Sized Cranial Defects Than Osteogenically Stimulated Constructs in Vivo, Tissue Engineering - Part A, 22, (5-6), 2016, p556-567Journal Article, 2016, DOI
• Luo, L., O'Reilly, A.R., Thorpe, S.D., Buckley, C.T., Kelly, D.J., Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels, Journal of Tissue Engineering and Regenerative Medicine, 11, (9), 2017, p2613-2628Journal Article, 2017, DOI
• Almeida, H.V., Eswaramoorthy, R., Cunniffe, G.M., Buckley, C.T., O'Brien, F.J., Kelly, D.J., Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration, Acta Biomaterialia, 36, 2016, p55-62Journal Article, 2016, DOI , TARA - Full Text
• Gonzalez-Fernandez, T., Tierney, E.G., Cunniffe, G.M., O'Brien, F.J., Kelly, D.J., Gene Delivery of TGF-ß3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering, Tissue Engineering - Part A, 22, (9-10), 2016, p776-787Journal Article, 2016, DOI , TARA - Full Text
• Pauly, H.M., Kelly, D.J., Popat, K.C., Trujillo, N.A., Dunne, N.J., McCarthy, H.O., Haut Donahue, T.L., Mechanical properties and cellular response of novel electrospun nanofibers for ligament tissue engineering: Effects of orientation and geometry, Journal of the Mechanical Behavior of Biomedical Materials, 61, 2016, p258-270Journal Article, 2016, DOI
• Steward, A.J., Kelly, D.J., Wagner, D.R., Purinergic Signaling Regulates the Transforming Growth Factor-ß3-Induced Chondrogenic Response of Mesenchymal Stem Cells to Hydrostatic Pressure, Tissue Engineering - Part A, 22, (11-12), 2016, p831-839Journal Article, 2016, DOI
• Almeida, H.V., Mulhall, K.J., O'Brien, F.J., Kelly, D.J., Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds, Journal of Tissue Engineering and Regenerative Medicine, 2016, p1-9-Journal Article, 2016, DOI , TARA - Full Text
• Verrier, S., Alini, M., Alsberg, E., Buchman, S.R., Kelly, D., Laschke, M.W., Menger, M.D., Murphy, W.L., Stegemann, J.P., Schütz, M., Miclau, T., Stoddart, M.J., Evans, C., Tissue engineering and regenerative approaches to improving the healing of large bone defects, European Cells and Materials, 32, 2016, p87-110Journal Article, 2016, URL , TARA - Full Text
• O'Reilly, A., Kelly, D.J., Unravelling the Role of Mechanical Stimuli in Regulating Cell Fate During Osteochondral Defect Repair, Annals of Biomedical Engineering, 44, (2), 2016, 3446-3459Journal Article, 2016, DOI , TARA - Full Text
• Mauck, R., Kelly, D., Editorial. The mechanical behaviour of cells, tissues and biomaterials, Journal of the mechanical behavior of biomedical materials, 38, 2014Journal Article, 2014
• Steward, A.J., Kelly, D.J., Wagner, D.R., Calcium signaling is a key regulator of mesenchymal stem cell response to hydrostatic pressure, ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 A, 2013Journal Article, 2013
• Gannon, A.R., Kelly, D.J., The changing depth dependant properties of articular cartilage during postnatal development, ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 A, 2013Journal Article, 2013
• Sheehy, E.J., Vinardell, T., Buckley, C.T., Kelly, D.J., Towards engineering whole bones via endochondral ossification, ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 B, 2013Journal Article, 2013
• Jacobs, C.R., Kelly, D.J., Cell mechanics: The role of simulation, Computational Methods in Applied Sciences, 20, 2011, p1-14Journal Article, 2011
• Steward, A.J., Thorpe, S.D., Vinardell, T., Buckley, C.T., Wagner, D.R., Kelly, D.J., Cell-Matrix interactions regulate mesenchymal stem cell response to extrinsic mechanical signals, 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011Journal Article, 2011
• Nagel, T., Kelly, D.J., Compaction and anisotropy induced by remodeling of the collagen network's state of tension-compression transition, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p597-598Journal Article, 2011
• Burke, D., Kelly, D.J., Could substrate stiffness and oxygen tension regulate stem cell differentiation during fracture healing?, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p609-610Journal Article, 2011
• Early, M., Kelly, D.J., Why are rates of restenosis higher in peripheral arteries than coronary arteries? A computational study, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p385-386Journal Article, 2009
• Lu, L., Chu, J., Rajalakshmanan, E., Mulhall, K., Kelly, D. J., Engineering tissues that mimic the zonal nature of articular cartilage using decellularized cartilage explants seeded with adult stem cells., ACS Biomaterials Science & Engineering , 2016Journal Article, 2016, DOI
• Rodenas-Rochina, J., Kelly, D.J., Gomez Ribelles, J., Lebourg, M. , Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells, Biomedical Physics & Engineering Express , 2, 2016, p035005Journal Article, 2016, DOI
• O'Reilly, A., Kelly, D.J, The role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects., Journal of Orthopaedic Research , 34, (6), 2016, p1026-36Journal Article, 2016, DOI , TARA - Full Text
• Daly, A.C., Critchley, S.E., Rencsok, E.M., Kelly, D.J., A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage, Biofabrication, 8, (4), 2016, p045002-Journal Article, 2016, DOI
• Saha, A., Rolfe, R., Carroll, S., Kelly, D.J., Murphy, P., Chondrogenesis of embryonic limb bud cells in micromass culture progresses rapidly to hypertrophy and is modulated by hydrostatic pressure, Cell and Tissue Research, 368, (1), 2017, p47-59Journal Article, 2017, DOI , URL
• Kelly, D.J., Barrie, M.B., Ross, R.A., Temple, B.A., Moses, L.M., Bausch, D.G., Housing equity for health equity: A rights-based approach to the control of Lassa fever in post-war Sierra Leone, BMC International Health and Human Rights, 2013Journal Article, 2013
• Daly A.C, Cunniffe G.M, Sathy B.N, Jeon O, Alsberg E, Kelly D.J, 3D Bioprinting: 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering (Adv. Healthcare Mater. 18/2016), Advanced Healthcare Materials, 5, (18), 2016, p2352-Journal Article, 2016, DOI , URL
• Almeida H.V, Cunniffe G.M, Vinardell T, Buckley C.T, O'Brien F.J, Kelly D.J, Coupling Freshly Isolated CD44⁺ Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis, Advanced Healthcare Materials, 4, (7), 2015, p1043 - 1053Journal Article, 2015, DOI , URL
• Henrique V. Almeida, Anna D. Dikina, Kevin J. Mulhall, Fergal J. O"Brien, Eben Alsberg, Daniel J. Kelly, Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells, ACS Biomaterials Science & Engineering, 3, (6), 2017, p1075-1082Journal Article, 2017, DOI , TARA - Full Text
• Cunniffe G.M, Díaz-Payno P.J, Ramey J.S, Mahon O.R, Dunne A, Thompson E.M, O'Brien F.J, Kelly D.J, Growth plate extracellular matrix-derived scaffolds for large bone defect healing, European Cells and Materials, 33, 2017, p130 - 142Journal Article, 2017, DOI , URL , TARA - Full Text
• Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 114, (10), 2017, p2400 - 2411Journal Article, 2017, URL
• Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691Journal Article, 2017, DOI
• Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238Journal Article, 2017, DOI , TARA - Full Text
• Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764Journal Article, 2017, DOI , TARA - Full Text
• Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436Journal Article, 2017, DOI , TARA - Full Text
• Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 11, 2017, p1700118 -Journal Article, 2017, DOI , TARA - Full Text
• DJ Kelly and PJ Prendergast, Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects, Journal of Biomechanics, 38, (7), 2005, p1413 - 1422Journal Article, 2005, DOI , URL , TARA - Full Text
• DJ Kelly and PJ Prendergast, Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis, Medical & Biological Engineering & Computing, 45, (1), 2004, p9 - 13Journal Article, 2004, DOI , URL
• Kelly, D J; Prendergast, P J; Blayney, A W, The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses, Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology, 24, (1), 2003, p11 - 19Journal Article, 2003, URL , TARA - Full Text
• Prendergast, P J; Kelly, D J; Rafferty, M; Blayney, A W, The effect of ventilation tubes on stresses and vibration motion in the tympanic membrane: a finite element analysis, Clinical Otolaryngology And Allied Sciences, 24, (6), 1999, p542 - 548Journal Article, 1999, DOI , URL
• Vedicherla S.V., Romanazzo S., Kelly D.J., Buckley C.T.* and Moran C.J.* , Chondrocyte based Intraoperative Processing Strategies for the Biological Augmentation of a Polyurethane Meniscal Replacement, Connective Tissue Research , 59, (4), 2017, 381-392Journal Article, 2017, DOI , TARA - Full Text
• Carroll, S.F., Buckley, C.T. and Kelly, D.J., Cyclic tensile strain can play a role in directing both intramembranous and endochondral ossification of mesenchymal stem cells., Frontiers in Bioengineering and Biotechnology, section Tissue Engineering and Regenerative Medicine. , 5, 2017, p73-Journal Article, 2017, DOI , TARA - Full Text
• Lebre, F., Sridharan, R., Sawkins, M.J., Kelly, D.J., O'Brien, F.J. and Lavelle, E.C., The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation, Scientific Reports, 7, (1), 2017, p2922 -Journal Article, 2017, DOI , URL , TARA - Full Text
• Pauly, H.M. and Sathy, B.N. and Olvera, D. and McCarthy, H.O. and Kelly, D.J. and Popat, K.C. and Dunne, N.J. and Haut Donahue, T.L., Hierarchically Structured Electrospun Scaffolds with Chemically Conjugated Growth Factor for Ligament Tissue Engineering, Tissue Engineering - Part A, 23, (15-16), 2017, p823-836Journal Article, 2017, DOI , URL , TARA - Full Text
• Olvera, D. and Sathy, B.N. and Carroll, S.F. and Kelly, D.J., Modulating microfibrillar alignment and growth factor stimulation to regulate mesenchymal stem cell differentiation, Acta Biomaterialia, 64, 2017, p148-160Journal Article, 2017, DOI , URL , TARA - Full Text
• Do Amaral, R.J.F.C. and Almeida, H.V. and Kelly, D.J. and O'Brien, F.J. and Kearney, C.J., Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy, Stem Cells International, 2017, 2017, p6843727-Journal Article, 2017, DOI , URL , TARA - Full Text
• Mahon, O.R. and O'Hanlon, S. and Cunningham, C.C. and McCarthy, G.M. and Hobbs, C. and Nicolosi, V. and Kelly, D.J. and Dunne, A., Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner, Acta Biomaterialia, 65, 2018, p426-435Journal Article, 2018, DOI , URL
• Andrew C Daly, Binulal N Sathy and Daniel J Kelly, Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions, Journal of Tissue Engineering, 6, 2018, p1-12Journal Article, 2018, DOI , TARA - Full Text
• De Oliveira, F.C.S. and Olvera, D. and Sawkins, M.J. and Cryan, S.-A. and Kimmins, S.D. and Da Silva, T.E. and Kelly, D.J. and Duffy, G.P. and Kearney, C. and Heise, A., Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling, Biomacromolecules, 18, (12), 2017, p4292-4298Journal Article, 2017, DOI , URL , TARA - Full Text
• Freeman, F.E. and Kelly, D.J., Tuning alginate bioink stiffness and composition for controlled growth factor delivery and to spatially direct MSC Fate within bioprinted tissues, Scientific Reports, 7, (1), 2017, p17042 -Journal Article, 2017, DOI , URL , TARA - Full Text
• Mulvihill, J.J.E. and Raykin, J. and Snider, E.J. and Schildmeyer, L.A. and Zaman, I. and Platt, M.O. and Kelly, D.J. and Ethier, C.R., Development of a Platform for Studying 3D Astrocyte Mechanobiology: Compression of Astrocytes in Collagen Gels, Annals of Biomedical Engineering, 46, (2), 2018, p365-374Journal Article, 2018, DOI , URL , TARA - Full Text
• Daly, A.C. and Freeman, F.E. and Gonzalez-Fernandez, T. and Critchley, S.E. and Nulty, J. and Kelly, D.J., 3D Bioprinting for Cartilage and Osteochondral Tissue Engineering, Advanced Healthcare Materials, 6, (22), 2017, p1700298 -Journal Article, 2017, DOI , URL , TARA - Full Text
• O'Reilly, A. and Kelly, D.J., A Computational Model of Osteochondral Defect Repair Following Implantation of Stem Cell-Laden Multiphase Scaffolds, Tissue engineering. Part A, 23, (1-2), 2017, p30-42Journal Article, 2017, DOI , URL , TARA - Full Text
• Almeida, H.V. and Sathy, B.N. and Dudurych, I. and Buckley, C.T. and O'Brien, F.J. and Kelly, D.J., Anisotropic Shape-Memory Alginate Scaffolds Functionalized with Either Type I or Type II Collagen for Cartilage Tissue Engineering, Tissue engineering. Part A, 23, (1-2), 2017, p55-68Journal Article, 2017, DOI , URL , TARA - Full Text
• S.Romanazzo, S.Vedicherla, C. Moran, D.J. Kelly, Meniscus ECM functionalized hydrogels containing infrapatellar fat pad derived stem cells for bioprinting of regionally defined meniscal tissue, J Tissue Eng Regen Med. , 2017, p1-10Journal Article, 2017, DOI , TARA - Full Text
• Amos Matsiko, Emmet M. Thompson, Cai Lloyd-Griffith, Gráinne M. Cunniffe, Tatiana Vinardell, John P. Gleeson, Daniel J. Kelly, Fergal J. O'Brien,, An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair, Journal of Tissue Engineering & Regenerative Medicine, 2018, pe2147-e2150Journal Article, 2018, DOI , TARA - Full Text
• Grainne Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly, 3D Bioprinting of PCL Reinforced Gene Activated Bioinks for Musculoskeletal Tissue Engineeringetal Tissue Engineering, Journal of Tissue Engineering, 2017, p1-Journal Article, 2017, TARA - Full Text
• D.J. Kelly, P.J. Prendergast, Variations in chondrocyte deformation throughout cartilage during loading: A poroelastic finite element analysis, ACTA of Bioengineering and Biomechanics: Proceedings of the 13th Conference of European Society of Biomechanics, 2003, 2003Meeting Abstract, 2003
• DJ Kelly, PJ Prendergast, A Mechanobiological analysis of osteochondral defect repair, Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, California, 2004, 2004Poster, 2004
• M Moretti, D Wendt, S C Dickinson, T J Sims, A P Hollander, D J Kelly, P J Prendergast, M Heberer, I Martin, Effects of in vitro pre-culture on the in vivo development of human engineered cartilage in an ectopic model, Tissue Engineering, 11, (9-10), 2005, p1421 - 1428Journal Article, 2005, DOI , URL
• Daly AC, Pitacco P, Nulty J, Cunniffe GM, Kelly DJ, 3D printed microchannel networks to direct vascularisation during endochondral bone repair, Biomaterials, 162, 2018, p34-46Journal Article, 2018, DOI , TARA - Full Text
• Ryan, A.J. and Kearney, C.J. and Shen, N. and Khan, U. and Kelly, A.G. and Probst, C. and Brauchle, E. and Biccai, S. and Garciarena, C.D. and Vega-Mayoral, V. and Loskill, P. and Kerrigan, S.W. and Kelly, D.J. and Schenke-Layland, K. and Coleman, J.N. and O'Brien, F.J., Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity, Advanced Materials, 30, (15), 2018, p1706442-Journal Article, 2018, DOI , URL
• , Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering, Tissue Engineering Part A, 2017Journal Article, 2017
• Susan E. Critchley, Rajalakshmanan Eswaramoorthy, Daniel J. Kelly, Low-oxygen conditions promote synergistic increases in chondrogenesis during co-culture of human osteoarthritic stem cells and chondrocytes, Journal of Tissue Engineering and Regenerative Medicine, 12, (4), 2018, 1074-1084Journal Article, 2018, DOI
• McMillan, A. and Nguyen, M.K. and Gonzalez-Fernandez, T. and Ge, P. and Yu, X. and Murphy, W.L. and Kelly, D.J. and Alsberg, E., Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering, Biomaterials, 161, 2018, p240-255Journal Article, 2018, DOI , URL
• Kelly, D.J. and O'Brien, F.J. and Prendergast, P.J., A Short History of Bioengineering Research in Ireland, Journal of Biomechanical Engineering, 140, (2), 2018, p021005Journal Article, 2018, DOI , URL
• Teixeira, B.N. and Aprile, P. and Mendonça, R.H. and Kelly, D.J. and Thiré, R.M.d.S.M., Evaluation of bone marrow stem cell response to PLA scaffolds manufactured by 3D printing and coated with polydopamine and type I collagen, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2018Journal Article, 2018, DOI , URL
• Cunniffe, G.M. and Gonzalez-Fernandez, T. and Daly, A. and Sathy, B.N. and Jeon, O. and Alsberg, E. and Kelly, D.J., * Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering, Tissue engineering. Part A, 23, (17-18), 2017, p891-900Journal Article, 2017, DOI , URL
• O'Reilly, A. and Kelly, D.J., A computational model of osteochondral defect repair following implantation of stem cell-laden multiphase scaffolds, Tissue Engineering - Part A, 23, (1-2), 2017, p30-42Journal Article, 2017, DOI , URL
• 1. Critchley, S., Cunniffe, G.M., O'Reilly, A., Diaz-Payno, P.J., McAlinden, A., Withers, D., Almeida, H.V., Alsberg, E., Kelly, D.J , Regeneration of osteochondral defects using developmentally inspired cartilaginous templates, Tissue Engineering Part A , 2018Journal Article, 2018, TARA - Full Text
• Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ, Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials. , 188, 2019, p63-73Journal Article, 2019, DOI , TARA - Full Text
• Rathan S., Dejob L., Schipani R., Haffner B., Mobius M.E., Kelly D.J., Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering, Advanced Healthcare Materials, 2019Journal Article, 2019, DOI , TARA - Full Text
• Gonzalez-Fernandez T, Rathan S, Hobbs C, Pitacco P, Freeman F.E, Cunniffe G.M, Dunne N.J, McCarthy H.O, Nicolosi V, O'Brien F.J, Kelly D.J, Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues, Journal of Controlled Release, 301, 2019, p13 - 27Journal Article, 2019, DOI , URL , TARA - Full Text
• Olvera D, Schipani R, Sathy B.N, Kelly D.J, Electrospinning of highly porous yet mechanically functional microfibrillar scaffolds at the human scale for ligament and tendon tissue engineering, Biomedical materials (Bristol, England), 14, (3), 2019, p035016-Journal Article, 2019, DOI , URL
• Sridharan R, Cavanagh B, Cameron A.R, Kelly D.J, O'Brien F.J, Material stiffness influences the polarization state, function and migration mode of macrophages, Acta Biomaterialia, 89, 2019, p47 - 59Journal Article, 2019, DOI , URL
• Sathy B.N, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy H.O, Dunne N, Jeon O, Alsberg E, Donahue T.L.H, Kelly D.J, Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells, Acta Biomaterialia, 88, 2019, p314 - 324Journal Article, 2019, DOI , URL , TARA - Full Text
• Daly A.C, Kelly D.J, Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers, Biomaterials, 197, 2019, p194 - 206Journal Article, 2019, DOI , URL , TARA - Full Text
• Sridharan R, Ryan E.J, Kearney C.J, Kelly D.J, O'Brien F.J, Macrophage Polarization in Response to Collagen Scaffold Stiffness Is Dependent on Cross-Linking Agent Used to Modulate the Stiffness, ACS Biomaterials Science and Engineering, 5, (2), 2019, p544 - 552Journal Article, 2019, DOI , URL
• Pauly H, Kelly D, Popat K, Easley J, Palmer R, Haut Donahue T.L, Mechanical properties of a hierarchical electrospun scaffold for ovine anterior cruciate ligament replacement, Journal of Orthopaedic Research, 37, (2), 2019, p421 - 430Journal Article, 2019, DOI , URL
• Iglesias C, Luo L, Martínez J, Kelly D.J, Taboada J, Pérez I, Obtaining the sGAG distribution profile in articular cartilage color images, Biomedizinische Technik, 2019Journal Article, 2019, DOI , URL
• Browe, D.C. and Mahon, O.R. and Díaz-Payno, P.J. and Cassidy, N. and Dudurych, I. and Dunne, A. and Buckley, C.T. and Kelly, D.J., Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering, Journal of Biomedical Materials Research - Part A, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• McDermott, A.M. and Herberg, S. and Mason, D.E. and Collins, J.M. and Pearson, H.B. and Dawahare, J.H. and Tang, R. and Patwa, A.N. and Grinstaff, M.W. and Kelly, D.J. and Alsberg, E. and Boerckel, J.D., Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration, Science Translational Medicine, 11, (495), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Mahon, O.R. and Kelly, D.J. and McCarthy, G.M. and Dunne, A., Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization, Osteoarthritis and Cartilage, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Schipani, R. and Nolan, D.R. and Lally, C. and Kelly, D.J., Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering, Connective Tissue Research, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Freeman, F.E. and Browe, D.C. and Diaz-Payno, P.J. and Nulty, J. and Von Euw, S. and Grayson, W.L. and Kelly, D.J., Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering, European Cells and Materials, 38, 2019, p168-187Journal Article, 2019, DOI , URL , TARA - Full Text
• Eamon J. Sheehy, Daniel J. Kelly, Fergal J. O' Brien, Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies, Materials Today Bio, 2019, p100009Journal Article, 2019, DOI , TARA - Full Text
• Extrusion-based additive manufacturing techniques for biomedical applications in, editor(s)Dermot Brabazon , Encyclopedia of Materials: Composites, Philadelphia, Elsevier, 2020, ppIn Press - [Tadayyon G, Kelly DJ, Monaghan MG]Book Chapter, 2020
• Olwyn R. Mahon, Daniel J. Kelly, Geraldine, M. McCarthy and Aisling Dunne, Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism , Osteoarthritis and Cartilage, 28, (5), 2020, 603-612Journal Article, 2020, DOI , TARA - Full Text
• Olwyn R. Mahon, David C. Brow, Tomas Gonzalez-Fernandez, Pierluca Pitaccoc, Ian T. Whelan, Stanislas Von E, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston. H. G. Mills , Daniel J. Kelly and Aisling Dunne, Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner, Biomaterials, 239, 2020, p119833-Journal Article, 2020, DOI , TARA - Full Text
• Rossana Schipani, Stefan Scheurer, Romain Florentin, Susan E Critchley and Daniel J Kelly, Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites , Biofabrication, 12, (3), 2020, p1--Journal Article, 2020, URL , TARA - Full Text
• Kian F. Eichholz and Stanislas Von Euw and Ross Burdis and Daniel J. Kelly and David A. Hoey, Development of a New Bone"Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating, Advanced Healthcare Materials, 2020, p2001102Journal Article, 2020, TARA - Full Text
• O†doherty, M. and Mulholland, E.J. and Chambers, P. and Pentlavalli, S. and Ziminska, M. and Chalanqui, M.J. and Pauly, H.M. and Sathy, B.N. and Donahue, T.H. and Kelly, D.J. and Dunne, N. and McCarthy, H.O., Improving the intercellular uptake and osteogenic potency of calcium phosphate via nanocomplexation with the RALA peptide, Nanomaterials, 10, (12), 2020, p1-16Journal Article, 2020, DOI , URL , TARA - Full Text
• Sridharan, R. and Genoud, K.J. and Kelly, D.J. and O'Brien, F.J., Hydroxyapatite Particle Shape and Size Influence MSC Osteogenesis by Directing the Macrophage Phenotype in Collagen-Hydroxyapatite Scaffolds, ACS Applied Bio Materials, 3, (11), 2020, p7562-7574Journal Article, 2020, DOI , URL
• Olvera, D. and Sathy, B.N. and Kelly, D.J., Spatial Presentation of Tissue-Specific Extracellular Matrix Components along Electrospun Scaffolds for Tissue Engineering the Bone-Ligament Interface, ACS Biomaterials Science and Engineering, 6, (9), 2020, p5145-5161Journal Article, 2020, DOI , URL
• Critchley, S. and Sheehy, E.J. and Cunniffe, G. and Diaz-Payno, P. and Carroll, S.F. and Jeon, O. and Alsberg, E. and Brama, P.A.J. and Kelly, D.J., 3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects, Acta Biomaterialia, 113, 2020, p130-143Journal Article, 2020, DOI , URL , TARA - Full Text
• Lemoine, M. and Casey, S.M. and O†Byrne, J.M. and Kelly, D.J. and O†Brien, F.J., The development of natural polymer scaffold-based therapeutics for osteochondral repair, Biochemical Society Transactions, 48, (4), 2020, p1433-1445Journal Article, 2020, DOI , URL
• Freeman, F.E. and Pitacco, P. and van Dommelen, L.H.A. and Nulty, J. and Browe, D.C. and Shin, J.-Y. and Alsberg, E. and Kelly, D.J., 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration, Science Advances, 6, (33), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Díaz-Payno, P.J. and Browe, D.C. and Cunniffe, G.M. and Kelly, D.J., The identification of articular cartilage and growth plate extracellular matrix-specific proteins supportive of either osteogenesis or stable chondrogenesis of stem cells, Biochemical and Biophysical Research Communications, 528, (2), 2020, p285-291Journal Article, 2020, DOI , URL , TARA - Full Text
• Von Euw, S. and Azaïs, T. and Manichev, V. and Laurent, G. and Pehau-Arnaudet, G. and Rivers, M. and Murali, N. and Kelly, D.J. and Falkowski, P.G., Solid-State Phase Transformation and Self-Assembly of Amorphous Nanoparticles into Higher-Order Mineral Structures, Journal of the American Chemical Society, 142, (29), 2020, p12811-12825Journal Article, 2020, DOI , URL , TARA - Full Text
• Westin, C.B. and Nagahara, M.H.T. and Decarli, M.C. and Kelly, D.J. and Moraes, Ã'.M., Development and characterization of carbohydrate-based thermosensitive hydrogels for cartilage tissue engineering, European Polymer Journal, 129, (109637), 2020Journal Article, 2020, DOI , URL
• Freeman, F.E. and Brennan, M.Ã . and Browe, D.C. and Renaud, A. and De Lima, J. and Kelly, D.J. and McNamara, L.M. and Layrolle, P., A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect, Frontiers in Bioengineering and Biotechnology, 8, (230), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Gouveia, P.J. and Hodgkinson, T. and Amado, I. and Sadowska, J.M. and Ryan, A.J. and Romanazzo, S. and Carroll, S. and Cryan, S.-A. and Kelly, D.J. and O'Brien, F.J., Development of collagen-poly(caprolactone)-based core-shell scaffolds supplemented with proteoglycans and glycosaminoglycans for ligament repair, Materials Science and Engineering C, (111657), 2020Journal Article, 2020, DOI , URL
• Tomas Gonzalez‐Fernandez Daniel J. Kelly Fergal J. O'Brien, Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions, Advanced Therapeutics, 1, (7), 2018Journal Article, 2018, DOI , TARA - Full Text
• Whelan IT, Moeendarbary E, Hoey DA, Kelly DJ., Biofabrication of vasculature in microphysiological models of bone., Biofabrication, 13, (3), 2021Journal Article, 2021, DOI , TARA - Full Text
• Freeman F.E., Burdis R., Kelly D.J., Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors, Trends in Molecular Medicine, 27, (7), 2021, p700 - 711, p700-711Journal Article, 2021, DOI , TARA - Full Text
• Freeman F.E., Burdis R., Mahon O.R., Kelly D.J., Artzi N., A Spheroid Model of Early and Late-Stage Osteosarcoma Mimicking the Divergent Relationship between Tumor Elimination and Bone Regeneration, Advanced Healthcare Materials, 2021Journal Article, 2021, DOI , TARA - Full Text
• Carroll SF, Buckley CT, Kelly DJ., Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins., Frontiers in bioengineering and biotechnology, 9, 2021, p591126Journal Article, 2021, DOI , TARA - Full Text
• Behan, K. and Dufour, A. and Garcia, O. and Kelly, D., Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering, Biomolecules, 12, (2), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Burdis, R. and Chariyev-Prinz, F. and Kelly, D.J., Bioprinting of biomimetic self-organised cartilage with a supporting joint fixation device, Biofabrication, 14, (1), 2022Journal Article, 2022, DOI , URL
• Pauly, H. and Fischenich, K. and Kelly, D. and Popat, K. and Easley, J. and Palmer, R.H. and Haut Donahue, T.L., The Effect of Anterior Cruciate Ligament Reconstruction with an Electropsun Scaffold on Tibiofemoral Contact Mechanics, Annals of Biomedical Engineering, 49, (12), 2021, p3748-3759Journal Article, 2021, DOI , URL
• Freeman, F.E. and Pitacco, P. and van Dommelen, L.H.A. and Nulty, J. and Browe, D.C. and Shin, J.-Y. and Alsberg, E. and Kelly, D.J., Development of a 3D Bioprinted Scaffold with Spatio-temporally Defined Patterns of BMP-2 and VEGF for the Regeneration of Large Bone Defects, Bio-protocol, 11, (21), 2021Journal Article, 2021, DOI , URL
• Shanley, L.C. and Mahon, O.R. and Kelly, D.J. and Dunne, A., Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages, Acta Biomaterialia, 133, 2021, p208-221Journal Article, 2021, DOI , URL , TARA - Full Text
• Levingstone, T.J. and Moran, C. and Almeida, H.V. and Kelly, D.J. and O'Brien, F.J., Layer-specific stem cell differentiation in tri-layered tissue engineering biomaterials: Towards development of a single-stage cell-based approach for osteochondral defect repair, Materials Today Bio, 12, (100173), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• McDermott, A.M. and Eastburn, E.A. and Kelly, D.J. and Boerckel, J.D., Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage, Journal of Biomechanics, 125, (110580), 2021Journal Article, 2021, DOI , URL
• Wang, B. and Díaz-Payno, P.J. and Browe, D.C. and Freeman, F.E. and Nulty, J. and Burdis, R. and Kelly, D.J., Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues, Acta Biomaterialia, 128, 2021, p130-142Journal Article, 2021, DOI , URL , TARA - Full Text
• Nulty, J. and Burdis, R. and Kelly, D.J., Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering, Frontiers in Bioengineering and Biotechnology, 9, (661989), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Sadowska, J.M. and Genoud, K.J. and Kelly, D.J. and O'Brien, F.J., Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue, Materials Today, 46, 2021, p136-154Journal Article, 2021, DOI , URL
• Nulty, J. and Freeman, F.E. and Browe, D.C. and Burdis, R. and Ahern, D.P. and Pitacco, P. and Lee, Y.B. and Alsberg, E. and Kelly, D.J., 3D bioprinting of prevascularised implants for the repair of critically-sized bone defects, Acta Biomaterialia, 126, 2021, p154-169Journal Article, 2021, DOI , URL , TARA - Full Text
• Burdis, R. and Kelly, D.J., Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues, Acta Biomaterialia, 126, 2021, p1-14Journal Article, 2021, DOI , URL , TARA - Full Text
• Jadwiszczak, J. and Kelly, D.J. and Guo, J. and Zhou, Y. and Zhang, H., Plasma Treatment of Ultrathin Layered Semiconductors for Electronic Device Applications, ACS Applied Electronic Materials, 3, (4), 2021, p1505-1529Journal Article, 2021, DOI
• Sridharan, R. and Kelly, D.J. and O'Brien, F.J., Substrate Stiffness Modulates the Crosstalk between Mesenchymal Stem Cells and Macrophages, Journal of Biomechanical Engineering, 143, (3), 2021Journal Article, 2021, DOI , URL
• Aprile, P. and Kelly, D.J., Hydrostatic Pressure Regulates the Volume, Aggregation and Chondrogenic Differentiation of Bone Marrow Derived Stromal Cells, Frontiers in Bioengineering and Biotechnology, 8, (619914), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Dufour, A. and Gallostra, X.B. and O'Keeffe, C. and Eichholz, K. and Von Euw, S. and Garcia, O. and Kelly, D.J., Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage, Biomaterials, 283, (121405), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Wang, B. and Chariyev-Prinz, F. and Burdis, R. and Eichholz, K. and Kelly, D.J., Additive manufacturing of cartilage-mimetic scaffolds as off-the-shelf implants for joint regeneration, Biofabrication, 14, (2), 2022Journal Article, 2022, DOI , URL
• Browe, D.C. and Díaz-Payno, P.J. and Freeman, F.E. and Schipani, R. and Burdis, R. and Ahern, D.P. and Nulty, J.M. and Guler, S. and Randall, L.D. and Buckley, C.T. and Brama, P.A.J. and Kelly, D.J., Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair, Acta Biomaterialia, 143, 2022, p266-281Journal Article, 2022, DOI , URL , TARA - Full Text
• Eichholz K.F., Goncalves I., Barcelo X., Federici A.S., Hoey D.A., Kelly D.J., How to design, develop and build a fully-integrated melt electrowriting 3D printer, Additive Manufacturing, 58, 2022Journal Article, 2022, DOI , TARA - Full Text
• Browe D.C., Burdis R., Diaz-Payno P.J., Freeman F.E., Nulty J.M., Buckley C.T., Brama P.A.J., Kelly D.J., Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds, Materials Today Bio, 16, 2022Journal Article, 2022, DOI , TARA - Full Text
• Burdis, R. and Chariyev-Prinz, F. and Browe, D.C. and Freeman, F.E. and Nulty, J. and McDonnell, E.E. and Eichholz, K.F. and Wang, B. and Brama, P. and Kelly, D.J., Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing, Biomaterials, 289, (121750), 2022Journal Article, 2022, DOI , URL
• Eichholz, K.F. and Freeman, F.E. and Pitacco, P. and Nulty, J. and Ahern, D. and Burdis, R. and Browe, D.C. and Garcia, O. and Hoey, D.A. and Kelly, D.J., Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects, Biofabrication, 14, (4), 2022Journal Article, 2022, DOI , URL
• Merrild, N.G. and Holzmann, V. and Ariosa-Morejon, Y. and Faull, P.A. and Coleman, J. and Barrell, W.B. and Young, G. and Fischer, R. and Kelly, D.J. and Addison, O. and Vincent, T.L. and Grigoriadis, A.E. and Gentleman, E., Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model, Acta Biomaterialia, 149, 2022, p179-188Journal Article, 2022, DOI , URL
• Díaz-Payno, P.J. and Browe, D.C. and Freeman, F.E. and Nulty, J. and Burdis, R. and Kelly, D.J., Gremlin-1 Suppresses Hypertrophy of Engineered Cartilage In Vitro but Not Bone Formation In Vivo, Tissue Engineering - Part A, 28, (15-16), 2022, p724-736Journal Article, 2022, DOI , URL
• Paetzold, R. and Coulter, F.B. and Singh, G. and Kelly, D.J. and O'Cearbhaill, E.D., Fused filament fabrication of polycaprolactone bioscaffolds: Influence of fabrication parameters and thermal environment on geometric fidelity and mechanical properties, Bioprinting, 27, (e00206), 2022Journal Article, 2022, DOI , URL
• Barceló, X. and Eichholz, K.F. and Garcia, O. and Kelly, D.J., Tuning the Degradation Rate of Alginate-Based Bioinks for Bioprinting Functional Cartilage Tissue, Biomedicines, 10, (7), 2022Journal Article, 2022, DOI , URL
• Aprile, P. and Whelan, I.T. and Sathy, B.N. and Carroll, S.F. and Kelly, D.J., Soft Hydrogel Environments that Facilitate Cell Spreading and Aggregation Preferentially Support Chondrogenesis of Adult Stem Cells, Macromolecular Bioscience, 22, (6), 2022Journal Article, 2022, DOI , URL
• Pitacco, P. and Sadowska, J.M. and O'Brien, F.J. and Kelly, D.J., 3D bioprinting of cartilaginous templates for large bone defect healing, Acta Biomaterialia, 2022Journal Article, 2022, DOI , URL
• Zhang, Y.S. and Haghiashtiani, G. and HÃŒbscher, T. and Kelly, D.J. and Lee, J.M. and Lutolf, M. and McAlpine, M.C. and Yeong, W.Y. and Zenobi-Wong, M. and Malda, J., 3D extrusion bioprinting, Nature Reviews Methods Primers, 1, (1), 2021Journal Article, 2021, DOI , URL
• Amin, B. and Shahzad, A. and Kelly, D. and O'Halloran, M. and Adnan Elahi, M., Anthropomorphic calcaneus phantom for microwave bone imaging applications, IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, 5, (3), 2021, p206-213Journal Article, 2021, DOI , URL
• Amin, B. and Sheridan, C. and Kelly, D. and Shahzad, A. and O'halloran, M. and Elahi, M.A., Microwave bone imaging: experimental evaluation of calcaneus bone phantom and imaging prototype, (9385055), 2020Conference Paper, 2020, DOI , URL
• Barceló, X. and Eichholz, K.F. and Gonçalves, I.F. and Garcia, O. and Kelly, D.J., Bioprinting of structurally organized meniscal tissue within anisotropic melt electrowritten scaffolds, Acta Biomaterialia, 158, 2023, p216-227Journal Article, 2023, DOI , URL
• Shanley, L.C. and Mahon, O.R. and O'Rourke, S.A. and Neto, N.G.B. and Monaghan, M.G. and Kelly, D.J. and Dunne, A., Macrophage metabolic profile is altered by hydroxyapatite particle size, Acta Biomaterialia, 2023Journal Article, 2023, DOI , URL
• Guler, S. and Eichholz, K. and Chariyev-Prinz, F. and Pitacco, P. and Aydin, H.M. and Kelly, D.J. and Vargel, Ä°., Biofabrication of Poly(glycerol sebacate) Scaffolds Functionalized with a Decellularized Bone Extracellular Matrix for Bone Tissue Engineering, Bioengineering, 10, (1), 2023Journal Article, 2023, DOI , URL
• Levingstone, T.J. and Sheehy, E.J. and Moran, C.J. and Cunniffe, G.M. and Diaz Payno, P.J. and Brady, R.T. and Almeida, H.V. and Carroll, S.F. and O'Byrne, J.M. and Kelly, D.J. and Brama, P.A. and O†Brien, F.J., Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model, Biomaterials and Biosystems, 8, (100066), 2022Journal Article, 2022, DOI , URL
• Baptista, L.S. and Porrini, C. and Kronemberger, G.S. and Kelly, D.J. and Perrault, C.M., 3D organ-on-a-chip: The convergence of microphysiological systems and organoids, Frontiers in Cell and Developmental Biology, 10, (1043117), 2022Journal Article, 2022, DOI , URL
• Whelan IT, Burdis R, Shahreza S, Moeendarbary E, Hoey DA, Kelly DJ., A microphysiological model of bone development and regeneration., Biofabrication, 2023Journal Article, 2023, DOI
• Kelly, D.J. and Zenobi-Wong, M., Editorial: Special Issue on biofabrication of cartilage, bone and their interface, Biofabrication, 15, (3), 2023Journal Article, 2023, DOI , URL
• Joyce, M. and Hodgkinson, T. and Lemoine, M. and González-Vázquez, A. and Kelly, D.J. and O'Brien, F.J., Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects, European cells & materials, 45, 2023, p158-172Journal Article, 2023, DOI , URL
• Barceló, X. and Garcia, O. and Kelly, D.J., Chondroitinase ABC Treatment Improves the Organization and Mechanics of 3D Bioprinted Meniscal Tissue, ACS Biomaterials Science and Engineering, 9, (6), 2023, p3488-3495Journal Article, 2023, DOI , URL
• Freeman, F.E. and Dosta, P. and Shanley, L.C. and Ramirez Tamez, N. and Riojas Javelly, C.J. and Mahon, O.R. and Kelly, D.J. and Artzi, N., Localized Nanoparticle-Mediated Delivery of miR-29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth, Advanced Materials, 35, (23), 2023Journal Article, 2023, DOI , URL
• Chariyev-Prinz, F. and Szojka, A. and Neto, N. and Burdis, R. and Monaghan, M.G. and Kelly, D.J., An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis, Journal of Biomechanics, 154, (111590), 2023Journal Article, 2023, DOI , URL
• Wang, B. and Barceló, X. and Von Euw, S. and Kelly, D.J., 3D printing of mechanically functional meniscal tissue equivalents using high concentration extracellular matrix inks, Materials Today Bio, 20, (100624), 2023Journal Article, 2023, DOI , URL
• Burdis, R. and Kronemberger, G.S. and Kelly, D.J., Engineering High-Quality Cartilage Microtissues Using Hydrocortisone Functionalized Microwells, Tissue Engineering - Part C: Methods, 29, (4), 2023, p121-133Journal Article, 2023, DOI , URL
• Chariyev-Prinz, F. and Neto, N. and Monaghan, M.G. and Kelly, D.J., Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure, Journal of Tissue Engineering and Regenerative Medicine, 2023, (9976121), 2023Journal Article, 2023, DOI , URL
• Gierlich, P. and Donohoe, C. and Behan, K. and Kelly, D.J. and Senge, M.O. and Gomes-Da-Silva, L.C., Antitumor Immunity Mediated by Photodynamic Therapy Using Injectable Chitosan Hydrogels for Intratumoral and Sustained Drug Delivery, Biomacromolecules, 25, (1), 2024, p24-42Journal Article, 2024, DOI , URL
• Angelica S Federici, Brooke Tornifoglio, Caitríona Lally, Orquidea Garcia, Daniel J Kelly, David A Hoey, Melt electrowritten scaffold architectures to mimic tissue mechanics and guide neo-tissue orientation, Journal of the Mechanical Behavior of Biomedical Materials, 150, 2024, p1 - 15Journal Article, 2024, DOI , TARA - Full Text
• Kian F Eichholz, Pierluca Pitacco, Ross Burdis, Farhad Chariyev-Prinz, Xavier Barceló, Brooke Tornifoglio, Ryan Paetzold, Orquidea Garcia, Daniel J Kelly, Integrating Melt Electrowriting and Fused Deposition Modeling to Fabricate Hybrid Scaffolds Supportive of Accelerated Bone Regeneration, Advanced Healthcare Materials, 13, 2023, p1 - 14Journal Article, 2023
• Salinas-Fernandez, S. and Garcia, O. and Kelly, D.J. and Buckley, C.T., The influence of pH and salt concentration on the microstructure and mechanical properties of meniscus extracellular matrix-derived implants, Journal of Biomedical Materials Research - Part A, 112, (3), 2024, p359-372Journal Article, 2024, DOI , URL , TARA - Full Text
• Sadowska, J.M. and Power, R.N. and Genoud, K.J. and Matheson, A. and González-Vázquez, A. and Costard, L. and Eichholz, K. and Pitacco, P. and Hallegouet, T. and Chen, G. and Curtin, C.M. and Murphy, C.M. and Cavanagh, B. and Zhang, H. and Kelly, D.J. and Boccaccini, A.R. and O'Brien, F.J., A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles, Advanced Materials, 36, (6), 2024Journal Article, 2024, DOI , URL
• Burdis, R. and Gallostra, X.B. and Kelly, D.J., Temporal Enzymatic Treatment to Enhance the Remodeling of Multiple Cartilage Microtissues into a Structurally Organized Tissue, Advanced Healthcare Materials, 13, (3), 2024Journal Article, 2024, DOI , URL
• Baptista, L.S. and Porrini, C. and S. Kronemberger, G. and Kelly, D.J. and Perrault, C.M., Corrigendum: 3D organ-on-a-chip: the convergence of microphysiological systems and organoids (Frontiers in Cell and Developmental Biology, (2022), 10, (1043117), 10.3389/fcell.2022.1043117), Frontiers in Cell and Developmental Biology, 12, (1365671), 2024Journal Article, 2024, DOI , URL
• Barceló, X. and Eichholz, K. and Gonçalves, I. and Kronemberger, G.S. and Dufour, A. and Garcia, O. and Kelly, D.J., Bioprinting of scaled-up meniscal grafts by spatially patterning phenotypically distinct meniscus progenitor cells within melt electrowritten scaffolds, Biofabrication, 16, (1), 2024Journal Article, 2024, DOI , URL
• O'Keeffe, C. and Taylor, D. and Lally, C. and Kelly, D.J., Morphological induced improvements in the bulk mechanical properties of chemically etched additively manufactured Ti-6Al-4V micro-struts, Additive Manufacturing, 75, (103748), 2023Journal Article, 2023, DOI
• O'Keeffe C., Kotlarz M., Goncalves I.F., Lally C., Kelly D.J., Chemical etching of Ti-6Al-4V biomaterials fabricated by selective laser melting enhances mesenchymal stromal cell mineralization, Journal of Biomedical Materials Research - Part A, 2024Journal Article, 2024, DOI , TARA - Full Text
• Federici, A.S., Tornifoglio, B., Lally, C., Garcia, O., Kelly, D.J., Hoey, D.A., Melt electrowritten scaffold architectures to mimic vasculature mechanics and control neo-tissue orientation, bioRxiv, 2023Journal Article, 2023, DOI
• Wang, B., Barceló, X., Euw, S.V., Kelly, D.J., 3D Printing of Mechanically Functional Meniscal Tissue Equivalents Using High Concentration Extracellular Matrix Inks, SSRN, 2022Journal Article, 2022
• Nulty, J., Freeman, F.E., Browe, D.C., Burdis, R., Ahern, D.P., Pitacco, P., Lee, Y.B., Alsberg, E., Kelly, D.J., 3D Bioprinting of Prevascularised Implants for the Repair of Critically Sized Bone Defects, SSRN, 2020Journal Article, 2020, DOI
• Burdis, R., Kelly, D.J., Biofabrication and Bioprinting Using Cellular Aggregates and Microtissues for the Engineering of Musculoskeletal Tissues, SSRN, 2020Journal Article, 2020, DOI
• Amin, B., Kelly, D., Shahzad, A., O'Halloran, M., Elahi, M.A., Microwave calcaneus phantom for bone imaging applications, 14th European Conference on Antennas and Propagation, EuCAP 2020, 2020Journal Article, 2020, DOI
• Gierlich, P., Donohoe, C., Behan, K., Kelly, D.J., Senge, M.O., Gomes"da"Silva, L.C., Systemic anti"tumor immunity mediated by photodynamic therapy using injectable chitosan hydrogels for intra"tumoral and sustained drug delivery, ChemRxiv, 2022Journal Article, 2022, DOI
• Susan E. Critchley, Rajalakshmanan Eswaramoorthy, Daniel J. Kelly, Low"oxygen conditions promote synergistic increases in chondrogenesis during co"culture of human osteoarthritic stem cells and chondrocytes, Journal of Tissue Engineering and Regenerative Medicine, 12, (4), 2018, p1074--1084Journal Article, 2018, DOI
• McDermott, A.M., Herberg, S., Mason, D.E., Pearson, H.B., Dawahare, J.H., Collins, J.M., Tang, R., Patwa, A.N., Grinstaff, M.W., Kelly, D.J., Alsberg, E., Boerckel, J.D., Recapitulating bone development for tissue regeneration through engineered mesenchymal condensations and mechanical cues, bioRxiv, 2017Journal Article, 2017, DOI
• Vázquez-García, I., Uhlitz, F., Ceglia, N., Lim, J.L.P., Wu, M., Mohibullah, N., Ruiz, A.E.B., Boehm, K.M., Bojilova, V., Fong, C.J., Funnell, T., Grewal, D., Havasov, E., Leung, S., Pasha, A., Patel, D.M., Pourmaleki, M., Rusk, N., Shi, H., Vanguri, R., Williams, M.J., Zhang, A.W., Broach, V., Chi, D., da Cruz Paula, A., Gardner, G.J., Kim, S.H., Lennon, M., Roche, K.L., Sonoda, Y., Zivanovic, O., Kundra, R., Viale, A., Derakhshan, F.N., Geneslaw, L., Maroldi, A., Nunez, R., Pareja, F., Stylianou, A., Vahdatinia, M., Bykov, Y., Grisham, R.N., Liu, Y.L., Lakhman, Y., Nikolovski, I., Kelly, D., Gao, J., Schietinger, A., Hollmann, T.J., Bakhoum, S.F., Soslow, R.A., Ellenson, L.H., Abu-Rustum, N.R., Aghajanian, C., Friedman, C.F., McPherson, A., Weigelt, B., Zamarin, D., Shah, S.P., Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes, bioRxiv, 2021Journal Article, 2021, DOI
• O"Keeffe, C., Zhang, W., Johnston, R.D., Promoppatum, P., Taylor, D., Lally, C., Kelly, D.J., Feature Size Specific Processing Parameters for Additively Manufactured Ti-6al-4v Micro-Strut Lattices, SSRN, 2024Journal Article, 2024, DOI , TARA - Full Text
• Federici, A., Garcia, O., Kelly, D.J., Hoey D.A.,, Muticomponent Melt-Electrowritten Vascular Graft to Mimic and Guide Regeneration of Small Diameter Blood Vessels, Advanced Functional Materials, 2409883, 2024Journal Article, 2024, DOI , URL , TARA - Full Text
• Joyce, M. and Hodgkinson, T. and Intini, C. and Dixon, J.E. and Kelly, D.J. and O†Brien, F.J., GENE ACTIVATED REINFORCED SCAFFOLDS FOR SOX9 DELIVERY TO ENHANCE REPAIR OF LARGE LOAD BEARING ARTICULAR CARTILAGE DEFECTS, European Cells and Materials, 47, 2024, p91-108Journal Article, 2024, DOI , URL
• Kronemberger GS, Spagnuolo FD, Karam AS, Chattahy K, Storey KJ, Kelly DJ., Rapidly Degrading Hydrogels to Support Biofabrication and 3D Bioprinting Using Cartilage Microtissues, ACS Biomater Sci Eng., 2024, p1--Journal Article, 2024, DOI , TARA - Full Text
• Kelly DJ, Prendergast PJ, Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair, Tissue Engineering, 12, (9), 2006, p2509 - 2519Journal Article, 2006, DOI , URL , TARA - Full Text
• Marenzana, M, Kelly, DJ, Prendergast, PJ, Brown, RA, A collagen-based interface construct for the assessment of cell-dependent mechanical integration of tissue surfaces, Cell and Tissue Research, 327, (2), 2007, p293 - 300Journal Article, 2007, DOI , URL
• Stents in, editor(s)Akay M , Wiley Encyclopaedia of Biomedical Engineering, John Wiley & Sons, 2006, [C Lally, DJ Kelly, PJ Prendergast]Book Chapter, 2006, URL
• Byrne, DP, Lacroix, D, Kelly, DJ, Plannel, J, Prendergast, PJ, Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus, and dissolution rate of a scaffold: application of mechanobiological models in tissue engineering, Biomaterials, 28, (36), 2007, p5544 - 5554Journal Article, 2007, DOI , URL
• Boccaccio, A., Pappalettere, C., Kelly, D.J, The influence of expansion rates on mandibular distraction osteogenesis: a computational analysis, Annals of Biomedical Engineering, 35, (11), 2007, p1940 - 1960Journal Article, 2007, DOI , URL , TARA - Full Text
• Guerin, S., O'Reilly, P., O'Byrne, J., Kelly, D.J, Hydrogen peroxide as a clinical irrigation solution: A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface, Biomedical Materials and Engineering, 17, (6), 2007, p379 - 386Journal Article, 2007, URL , TARA - Full Text
• Boccaccio A, Prendergast PJ, Pappalettere C, Kelly DJ, Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period, Medical and Biological Engineering and Computing, 46, (3), 2008, p283 - 298Journal Article, 2008, DOI , URL , TARA - Full Text
• Vard, J.P., Kelly, D.J., Blayney, A.W. and Prendergast, P.J. , The influence of ventilation tube design on the magnitude of stress imposed at the implant/tympanic membrane interface, Medical Engineering and Physics, 30, (2), 2008, p154-163Journal Article, 2008, DOI , URL , TARA - Full Text
• D.J. Kelly, A. Crawford, S.C. Dickinson, T.J. Sims, A.P. Hollander, P.J. Prendergast and P.V. Hatton, Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage, Journal of Materials Science: Materials in Medicine, 18, (2), 2007, p273-281Journal Article, 2007, DOI , URL , TARA - Full Text
• D.P. Byrne, D. Lacroix, D.J. Kelly and P.J. Prendergast, The effect of loading on bone regeneration in a regular structured scaffold, Proceedings of the 3rd International Conference on Computational Bioengineering, 3rd International Conference on Computational Bioengineering, Universidad Central de Venezuela, Caracas , edited by M. Cerrolaza , 2007, pp215-220Conference Paper, 2007
• Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., A comparative study of shear stresses in collagen-GAG and calcium phosphate scaffolds in bone tissue-engineering bioreactors., Tissue Engineering Part A, 15, (5), 2009, p1141-1149Journal Article, 2009, DOI , URL
• Jungreuthmayer, C., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model., Medical Engineering and Physics , 31, (4), 2009, p420-427Journal Article, 2009, DOI , URL , TARA - Full Text
• Pericevic, I., Lally, C., Toner, D., Kelly, D.J. , The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents, Medical Engineering and Physics , 31, (4), 2009, p428-433Journal Article, 2009, DOI , URL , TARA - Full Text
• Buckley, C.T., Thorpe, S.D., O'Brien, F.J., Robinson, A.J., Kelly, D.J. , The effect of concentration, cooling rate and cell seeding density on the initial mechanical properties of agarose hydrogels., Mechanical Behaviour of Biomedical Materials , 2, (5), 2009, p512 - 521Journal Article, 2009, DOI , TARA - Full Text
• Thorpe, S. D., Buckley, C. T., Vinardell, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 337, (2), 2008, p458-462Journal Article, 2008, DOI , URL , TARA - Full Text
• Mechanobiological models of Skeletal Tissue Differentiation in, editor(s)Tomasz Lekszycki & Pawel Maldyk , Biomaterials in Orthopaedic Practice, Warsaw, Polish Academy of Sciences,, 2005, pp1 - 20, [DJ Kelly]Book Chapter, 2005, TARA - Full Text
• Modelling the response of cells to mechanical stimulation in, editor(s)Józef Joachim Telega , Modelling in Biomechanics: Lecture Notes 19 of AMAS, Warsaw, Institute of Fundamental Technological Research, 2004, pp159-189 , [PJ Prendergast, DJ Kelly, JG McGarry.]Book Chapter, 2004
• Vinardell, T., Thorpe, S., Buckley, C., Kelly, D.J., Chondrocytes demonstrate superior integration than mesenchymal stem cells in a cartilage explant defect model., Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009Meeting Abstract, 2009
• Haut Donadue, T., Thorpe, S., Buckley, C., Kelly, D.J., The Response of Inner vs. Outer Zone Meniscal Cells to Unconfined Compression. , Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009Meeting Abstract, 2009
• Thorpe, S., Vinardell, T., Buckley, C., Kelly, D.J., Dynamic Compressive Loading can Inhibit Chondrogenesis of Bone Marrow Derived Mesenchymal Progenitor Cells, Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009Meeting Abstract, 2009
• Buckley, C., Thorpe, S., Kelly, D.J. , The Effect of Dynamic Rotational Culturing on Chondrocytes in a Microchannel Agarose Hydrogel Environment., Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009Meeting Abstract, 2009
• Buckley, C., Gallagher, J., Thorpe, S., Kelly, D.J. , In vitro dynamic loading of micro-channelled chondrocyte seeded hydrogel constructs. , 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008Conference Paper, 2008
• Pericevic, I., Lally, C., Toner, D., Kelly, D.J., FE analysis of stent expansion considering the influence of plaque composition and inflation pressure., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008Conference Paper, 2008
• Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J, A comparative numerical 3D CFD of two tissue engineering scaffolds subjected to fluid flow., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008Conference Paper, 2008
• Early, M., Kelly, D.J, Influence of stent type and arterial properties and geometry on stent-artery interactions, 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008Conference Paper, 2008
• Kearney, P., Lally, C., Kelly, D.J., An iterative diffusive-convective model of drug transport and binding in the artery wall, 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008Conference Paper, 2008
• Byrne, D. P., Lacroix, D., Kelly, D. J., Prendergast, P. J., Modelling cell dispersal in the fracture callus., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008Conference Paper, 2008
• Early, M. & Kelly, DJ, A study of the factors affecting stresses in peripheral arteries following stent placement, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp58-59Conference Paper, 2007
• Jungreuthmayer, C., Jaasma, M.J., Kelly, D.J., O'Brien, F.J., 3D numerical simulation of a flow perfusion bioreactor for bone tissue engineering, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp108-109Conference Paper, 2007
• Byrne, D.P., Lacroix, D., Kelly, D.J., Prendergast, P.J., Finite element modeling of dissolution of a regular structured scaffold for tissue engineering, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp134-135Conference Paper, 2007
• Kelly, D.J. & Boccaccio, A, Tissue differentiation and bone regeneration in an osteootmized and distracted mandible, Journal of Biomechanics, Proceedings of the V World Congress of Biomechanics, Munich, Germany, 39, (Supp 1), 2006, ppS415Conference Paper, 2006
• Early, M., Kelly, D.J., An analysis of stresses in peripheral arteries following stenting using the finite element method, Journal of Biomechanics, Proceedings of the V World Congress of Biomechanics, Munich, Germany, 39, (Supp 1), 2006, ppS328Conference Paper, 2006
• Kelly, D.J. & Prendergast, P.J., Computational optimization of the mechanical properties for a scaffold used in osteochondral defect repair, American Society of Mechanical Engineers Summer Bioengineering Meeting, 52, 2006Meeting Abstract, 2006
• Prendergast, P.J., Kelly, D.J., McMahon, L.A., Campbell, V.A. , A computational optimization of scaffolds for tissue engineering of cartilage., Tissue Engineering, Abstracts of 8th TESI Annual Meeting 2005, Shanghai, China, October 22-25, 12, 2006, pp1024Meeting Abstract, 2006
• Byrne, D.P., Prendergast, P.J., Kelly, D.J., Optimisation of scaffold porosity using a stochastic model for cell proliferation and migration in mechanobiological simulations, Journal of Biomechanics , Proceedings of the V World Congress of Biomechanics, Munich, Germany., 39, (1), 2006, ppS413Conference Paper, 2006
• Prendergast, P.J., Kelly, D.J., Perez, M.A., Computational models for the study of the mechanobiology of bone regeneration, European Society of Biomechanics Thematic Workshop: Mechanobiology of Cells and Tissue Regeneration, Leuven, Aug 2005, 2005, pp29-30Conference Paper, 2005
• Kelly, D.J. & Prendergast, P.J. , Using a mechano-regulation model for tissue differentiation to design an optimised scaffold for osteochondral defect repair, Proceedings of the 14th Conference of the European Society of Biomechanics, 14th Conference of the European Society of Biomechanics, S-Hertogenbosch, The Netherlands, 2004Conference Paper, 2004
• Kelly, D.J. & Prendergast, P.J., A mechanobiological analysis of osteochondral defect repair, Trans. U.S. 48th Orthopaedic Research Society, 14th Conference of the European Society of Biomechanics, San Francisco, 2003, pp666Conference Paper, 2003
• Moretti, M., Wendt, D., Dickinson, S., Hollander, A., Kelly, D.J., Prendergast, P.J., Herberer, M. & Martin, I. , In vivo development of human engineered cartilage is enhanced by the in vivo pre-culture, only under specific conditions., Trans. U.S. 48th Orthopaedic Research Society, 14th Conference of the European Society of Biomechanics, San Francisco, 2003, pp698Conference Paper, 2003
• Kelly, D.J. & Prendergast, P.J., The influence of defect size and scaffold material properties on osteochondral defect repair., Proceedings of the 2003 Annual Fall Meeting of the Biomedical Engineering Society, Proceedings of the 2003 Annual Fall Meeting of the Biomedical Engineering Society, 2003Conference Paper, 2003
• Kelly, D.J. & Prendergast, P.J. , Variations in chondrocyte deformation throughout cartilage during loading: a poroelastic finite element analysis. , Acta of Biomechanics and Bioengineering, 4, (1), 2002, pp439-440Conference Paper, 2002
• Kelly, D.J. & Prendergast, P.J., An investigation of middle-ear biomechanics using finite element modelling,, American Society of Mechanical Engineers Summer Bioengineering Meeting, 50, 2001, pp369-370Conference Paper, 2001
• Kelly, D.J., Prendergast, P.J., Rafferty, M. & Blayney, A.W., Grommet design affects the vibratory motion of the tympanic membrane, Proceedings of the 12th Conference of the European Society of Biomechanics, 12th Conference of the European Society of Biomechanics, Royal Academy of Medicine in Ireland, Dublin, 2000, pp191Conference Paper, 2000
• Reilly, G., Fitzpatrick, D.(ed.), Proceedings of Bioengineering in Ireland, 2008, 97 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Proceedings of Bioengineering in Ireland, Dublin, 2008, 2008, 49 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Proceedings of Bioengineering in Ireland, Dublin, 2008, 7 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2008, 31 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2008, 44 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, 2008, 59 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2008, 30 pProceedings of a Conference, 2008
• Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , Dublin, 2008, 28 pProceedings of a Conference, 2008
• Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 78 pProceedings of a Conference, 2007
• Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 77 pProceedings of a Conference, 2007
• Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 33 pProceedings of a Conference, 2007
• Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 63 pProceedings of a Conference, 2007
• Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 75 pProceedings of a Conference, 2007
• McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 106 pProceedings of a Conference, 2006
• McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 115 pProceedings of a Conference, 2006
• McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 56 pProceedings of a Conference, 2006
• McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 82 pProceedings of a Conference, 2006
• Vard, J.P., Prendergast, P.J., Kelly, D. & Blayney, A.J., Investigating the theory of grommet induced tympanosclerosis using finite element analysis, Proceedings of Bioengineering in Ireland , Bioengineering in Ireland , edited by FitzPatrick, D.P., Senouci, M., , 2005, pp7Conference Paper, 2005
• Kelly, D.J., Waller, M.A., Dickinson, S.C., Hollander, A.P., Crawford, A.C., Hatton, P.V. & Prendergast, P.J., Can a functional engineered cartilage tissue be grown in a static culture?, Proceedings of Bioengineering in Ireland, Bioengineering in Ireland, edited by Fitzpatrick, D.P., McCormack, B.A.O., McCormack, D. , 2004, pp20Conference Paper, 2004
• Kelly, D.J. & Prendergast, P.J. , The poor quality repair tissue that forms in osteochonrdal defects can be attributed to the local mechanical environment within the defect, Proceedings of Bioengineering in Ireland, Bioengineering in Ireland, edited by Fitzpatrick, D.P., McCormack, B.A.O., McCormack, D. , 2003, pp75Conference Paper, 2003
• Lyons, A.D., Lally, C., Kelly, D.J., Lang, E., Blayney, A.W. & Prendergast, P.J. , Elasticity of tragal cartilage and Temporalis Fascia, and tympanic membrane vibration after tympanoplasty using these tissues, Proceedings of Bioengineering in Ireland, Bioengineering in Ireland, edited by Fitzpatrick, D.P., McCormack, B.A.O., McCormack, D. , 2003, pp57Conference Paper, 2003
• Buckley, C.T., Thorpe, S.D., Kelly, D.J. , Engineering of large cartilaginous constructs through the use of microchanneled hydrogels and rotational culture, Tissue Engineering A, 15, (11), 2009, p3213-3220Journal Article, 2009, DOI , TARA - Full Text
• Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. , Tensile and compressive properties of fresh human carotid atherosclerotic plaques. , Journal of Biomechanics, 42, (16), 2009, p2760-2767Journal Article, 2009, DOI , TARA - Full Text
• Buckley C.T., Thorpe S.D. and Kelly D.J., The Influence of Dynamic Rotational Culturing on Chondrocyte Seeded Microchanneled Agarose Hydrogels, Tissue Engineering Part A, 15, (11), 2009, p3213-3220Journal Article, 2009
• Vinardell T., Thorpe S.D., Buckley C.T. and Kelly D.J. , Chondrogenesis and integration of bone marrow derived mesenchymal stem cells and chondrocytes within an in vitro cartilage defect repair model. , Annals of Biomedical Engineering , 37, (12), 2009, p2556 - 2565Journal Article, 2009
• Computational techniques for selection of biomaterial scaffolds for tissue engineering in, editor(s)P.R. Fernandes, P. Bártolo , Advances on Modelling in Tissue Engineering , Berlin, Springer, 2011, [Checa, S, Sandino, C, Byrne DP, Kelly, DJ, Lacroix, D & Prendergast, PJ]Book Chapter, 2011
• Vinardell, T; Thorpe, S D; Buckley, C T; Kelly, D J, Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model, Annals of Biomedical Engineering, 37, (12), 2009, p2556-2565Journal Article, 2009, DOI , URL , TARA - Full Text
• Thomas Nagel and Daniel J. Kelly, Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair, Biomechanics and Modeling in Mechanobiology, 9, (3), 2009, p359-372Journal Article, 2009, DOI , URL , TARA - Full Text
• Partap, S., Plunkett, N.A., Kelly, D.J., O'Brien, F.J. , Stimulation of Osteoblasts Using Rest Periods during Bioreactor Culture on Collagen-Glycosaminoglycan Scaffolds., Journal of Material Science, 21, (8), 2010, p2325-2330Journal Article, 2010, DOI , URL
• Buckley, C T; Vinardell, T; Thorpe, S D; Jones, E; McGonagle, D; Kelly, D J. , Functional Properties of Cartilaginous Tissues Engineered From Infrapatellar Fat Pad Derived Mesenchymal Stem Cells. , Journal of Biomechanics , 43, (5), 2010, p920-926Journal Article, 2010, DOI , URL , TARA - Full Text
• Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Stress analysis in patient-specific models of carotid bifurcation: automated geometry reconstruction based on in vivo CT images, Computers in Biology and Medicine , 2010Journal Article, 2010
• Early, M., Kelly, D.J. , The role of vessel geometry and material properties on the mechanics of stenting in the coronary and peripheral arteries., Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224, (3), 2010, p465-476Journal Article, 2010, DOI , URL
• Michael Early; Catriona Lally; Patrick J. Prendergast; Daniel J. Kelly, Stresses in peripheral arteries following stent placement: a finite element analysis, Computer Methods in Biomechanics and Biomedical Engineering, 12, (1), 2009, p25 - 33Journal Article, 2009, DOI , URL , TARA - Full Text
• Vinardell T, Thorpe S, Buckley C, Kelly D. , Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 3rd UK Mesenchymal Stem Cell Meeting, Sheffield, UK, 2009Meeting Abstract, 2009
• Vinardell T, Thorpe S, Buckley C, Kelly D., Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, USA, 2009Meeting Abstract, 2009
• Vinardell T, Buckley C, Thorpe S, Kelly D , Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., European Cells and Materials , X European Cells and Materials Conference, Stem Cells for musculoskeletal regeneration, Davos, Switzerland, June 29- July 1, 18, (1), 2009, pp63Meeting Abstract, 2009
• Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA , 2010Meeting Abstract, 2010
• Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 3rd International Conference on Mechanics of Biomaterials and Tissues, Clearwater Beach, USA, 2009Oral Presentation, 2009
• Meyer EG, Buckley CT, Thorpe SD, Kelly DJ., Low oxygen tension: A more potent chondrogenic stimulus than dynamic compression for bone marrow derived MSCs in agarose hydrogel culture., . 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6 - 9, 2010Meeting Abstract, 2010
• Meyer EG, Haugh MG, Buckley CT, Kelly DJ., Monolayer expansion and cell seeding density influence the functional properties of cartilaginous tissues engineered using MSCs., Orthopedic Research Society Meeting, New Orleans, LA, 2010Meeting Abstract, 2010
• Buckley CT, Thorpe SD, O'Brien FJ, Robinson AJ, Kelly DJ, The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels., Journal of the Mechanical Behavior of Biomedical Materials, 2, (5), 2009, p512-21Journal Article, 2009, DOI , URL
• Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents., Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, (1921), 2010, p2919-35Journal Article, 2010, DOI , URL , TARA - Full Text
• Nagel, T., Kelly, D.J. , The Influence of Fibre Orientation on the Equilibrium Properties of Neutral and Charged Biphasic Tissues, Journal of Biomechanical Engineering , 132, (11), 2010, p1-19Journal Article, 2010, DOI , URL
• Daniel J. Kelly, Christopher R. Jacobs, The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells, Birth Defects Research Part C: Embryo Today: Reviews, 90, (1), 2010, p75-85Journal Article, 2010, DOI , URL , TARA - Full Text
• Meyer EG, Buckley CT, Thorpe SD, Kelly DJ., Low oxygen tension is a more potent promoter of chondrogenic, Journal of Biomechanics, 43, (13), 2010, p2516-2523Journal Article, 2010, DOI , URL , TARA - Full Text
• A. Boccaccio , D.J. Kelly & C. Pappalettere, A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies, Journal of Orthopaedic Research, 29, (3), 2010, p433-443Journal Article, 2010, DOI , URL , TARA - Full Text
• T. Vinardell, C.T. Buckley, S. D. Thorpe, and D. J. Kelly, Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad, Journal of Tissue Engineering and Regenerative Medicine, 5, (9), 2011, p673-683Journal Article, 2011, DOI , URL , TARA - Full Text
• Buckley CT, Vinardell T, Kelly DJ., Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes., Osteoarthritis Cartilage., 18, (10), 2010, p1345-1354Journal Article, 2010, DOI , URL , TARA - Full Text
• Thorpe, S. D., Buckley, C. T., Vinardel, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , The response of bone marrow derived mesenchymal stem cells to dynamic compression following TGF-â3 induced chondrogenic differentiation, Annals of Biomedical Engineering , 38, (9), 2010, p2896-2909Journal Article, 2010, DOI
• Kasiri, S., Kelly, D.J. Taylor, D. , Can The Theory of Critical Distances Predict the Failure of Shape Memory Alloys?, Computer Methods in Biomechanics and Biomedical Engineering , 14, (6), 2011, p491-496Journal Article, 2011, DOI
• Meyer E.G., Buckley C.T., Thorpe, S.D. and Kelly D.J. , Low Oxygen Tension is a More Potent Regulator of Chondrogenic Differentiation Than Dynamic Compression for Bone Marrow Derived Mesenchymal Stem Cells., Tissue Engineering and Regenerative Medicine International Society - EU Meeting, Galway, Ireland, 2010Conference Paper, 2010
• Sheehy, E.J., Buckley C.T., and Kelly D.J. , Cartilaginous tissue engineering using chondrocytes and bone marrow derived MSCs by a combination of rotational culture and modified scaffold architecture, Tissue Engineering and Regenerative Medicine International Society - EU Meeting, Galway, Ireland,, 2010Oral Presentation, 2010
• Nagel, T., Kelly D.J., Modelling the Evolution of Tissue Phenotype and Structure During Skeletal Regeneration, Tissue Engineering and Regenerative Medicine International Society - EU Meeting, Galway, Ireland, 2010Conference Paper, 2010
• Mesallati, T.S., Buckley, C.T., Kelly, D.J., The effect of introducing microchannels into dynamically compressed chondrocyte-seeded hydrogels, 8th International Conference on Cell & Stem Cell Engineering (ICCE), , Dublin, 11-12th June 2010. , 2010Oral Presentation, 2010
• Meyer E.G., Buckley C.T., Kelly D.J, The Effect of Cyclic Hydrostatic Pressure and Low Oxygen Tension on the Chondrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells., 8th International Conference on Cell & Stem Cell Engineering (ICCE), , Dublin, 11-12th June, 2010Oral Presentation, 2010
• Meyer E.G., Haugh M.G., Buckley C.T. and Kelly D.J. , Monolayer expansion and cell seeding density influence the functional properties of cartilaginous tissues engineered using MSCs., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, March 6 - 9, 2010Meeting Abstract, 2010
• Meyer E.G., Buckley C.T., Thorpe S.D. and Kelly D.J., Low oxygen tension: A more potent chondrogenic stimulus than dynamic compression for bone marrow derived MSCs in agarose hydrogel culture., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010Meeting Abstract, 2010
• Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic Compression Post TGF-â3 Induced Differentiation Augments Chondrogenesis of Mesenchymal Stem Cells., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010Meeting Abstract, 2010
• Partap S, Plunkett N, Kelly DJ, O'Brien F., Rest Periods During Bioreactor Culture Restore Mechanosensitivity and Enhance Osteogenesis, 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010Poster, 2010
• Vinardell T, Buckley C.T. and Kelly D.J. , Mechanical Behaviour of Cartilaginous Tissues Engineered from Mesenchymal Stem Cells Isolated from Different Tissue Sources, Third International Conference on Mechanics of Biomaterials and Tissues, Clearwater Beach, Florida, USA, 13 - 17 December , 2009Meeting Abstract, 2009
• Thorpe, S., Buckley, C., Kelly, D.J., Chondrogenesis of Mesenchymal Stem Cells is Differentially Regulated by Temporal Application of Dynamic Compression, ECM X: Stem Cells for Musculoskeletal Regeneration, Davos, Switzerland, 2009Meeting Abstract, 2009
• E.G. Meyer, C.T. Buckley, A.J. Steward, D.J. Kelly, The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells, Journal of the Mechanical Behavior of Biomedical Materials, 4, (7), 2011, p1257-1265Journal Article, 2011, DOI , URL , TARA - Full Text
• Sheehy E.J., Buckley C.T. and Kelly D.J., Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions., Tissue Engineering & Regenerative Medicine., 5, (9), 2011, p747-758Journal Article, 2011, DOI
• Mesallati T., Buckley C.T., Nagel T. and Kelly D.J., Introducing microchannels into chondrocyte-seeded agarose hydrogels influences matrix accumulation in response to dynamic compression and TGF-â3 stimulation., IFMBE Proceedings , 8th International Conference on Cell & Stem Cell Engineering (ICCE) , 30, 2011, pp26-30Conference Paper, 2011, DOI
• Thorpe S.D., Buckley C.T., and Kelly D.J., Can dynamic compression in the absence of growth factors induce chondrogenic differentiation of bone marrow derived MSCs encapsulated in agarose hydrogels?, IFMBE Proceedings, IFMBE, 30, 2011, pp43-46Conference Paper, 2011
• Meyer, E.G., Buckley, C.T., and Kelly, D.J. , The Effect of Cyclic Hydrostatic Pressure on the Functional Development of Cartilaginous Tissues Engineered Using Bone Marrow Derived Mesenchymal Stem Cells., ASME 2011 Summer Bioengineering Conference, Pennsylvania, US, June 22nd-25th, ASME, 2011Meeting Abstract, 2011
• Thorpe S.D., Buckley C.T., Steward, A.J and Kelly D.J. , Cell-Matrix Interactions Modulate Mesenchymal Stem Cell Response To Dynamic Compression, ASME 2011 Summer Bioengineering Conference, Pennsylvania, USA, June 22nd-25th, ASME, 2011Meeting Abstract, 2011
• Vinardell T., Buckley C.T., Meyer E.G. and Kelly D.J. , Hydrostatic pressure and TGF-beta3 interact to regulate chondrogenesis of joint derived mesenchymal stem cells., Tissue Engineering and Regenerative Medicine International Society (TERMIS), Granada, Spain, 7th-10th June, 2011Meeting Abstract, 2011
• Buckley, C.T., Meyer, E.G. and Kelly, D.J. , Expansion in the Presence of FGF-2 Modulates the Temporal Development of Cartilaginous Tissues Engineered Using Infrapatellar Fat Pad Derived MSCs, Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA, January 13th-16th, 2011Meeting Abstract, 2011
• Meyer, E.G., Buckley, C.T., and Kelly, D.J. , The Functional Properties of Cartilaginous Tissues Engineered Using Bone-Marrow Derived MSCs Improve As They Are Scaled Towards Geometries of Clinical Relevance. , Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA., January 13th-16th, 2011Meeting Abstract, 2011
• Sheehy, E.J., Vinardell, T., Meyer, E.G., Buckley, C.T. and Kelly, D.J. , The oxygen environment regulates mesenchymal stem cell expansion and chondrogenic differentiation in an in vitro cartilage defect model., Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA, January 13th-16th, 2011Meeting Abstract, 2011
• Buckley C.T., Vinardell T. and Kelly D.J., Infrapatellar Fat Pad Derived MSCs as a Potential Alternative to Chondrocytes for Cartilage Repair- Chondrogenesis in a Physiologically Relevant Low Oxygen Tension Environment., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April, 2010Meeting Abstract, 2010
• Meyer E.G., Buckley C.T., Haugh M.G. and Kelly D.J., The influence of expansion on the resulting functional properties of cartilaginous tissues generated from MSCs., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April , 2010Meeting Abstract, 2010
• Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic compression of mesenchymal stem cells following cytokine induced differentiation augments glycosaminoglycan synthesis., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April, 2010Meeting Abstract, 2010
• Haugh, M.G., Meyer, E.G., Thorpe, S.D., Vinardell, T., Duffy, G.P. and Kelly, D.J., Temporal and Spatial Changes in Cartilage-Matrix Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression., Tissue Engineering Part A , 23-24, 2011, p3085-3093Journal Article, 2011, DOI
• Early, M., Kelly D.J. , The consequences of the mechanical environment of peripheral arteries for nitinol stenting., Medical and Biological Engineering and Computing, 49, (11), 2011, p1279-1288Journal Article, 2011, DOI
• Hoey, D.A., Kelly, D.J., Jacobs, C.R., A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 412, (1), 2011, p182-187Journal Article, 2011, DOI , URL , TARA - Full Text
• Nagel, T., Kelly, D.J., Remodelling of collagen fibre transition stretch and angular distribution in soft biological tissues and cell-seeded hydrogels., Biomechanics and Modeling in Mechanobiology, 11, (3-4), 2012, p325-339Journal Article, 2012, DOI
• Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J., Inelasticity of Human Carotid Atherosclerotic Plaque. , Annals of Biomedical Engineering, 39, (9), 2011, p2445-2455Journal Article, 2011, DOI
• Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Nagel, T., Kelly, D.J., Prediction of fibre architecture and adaptation in diseased carotid bifurcations. , Biomechanics and Modeling in Mechanobiology , 10, (6), 2011, p831-843Journal Article, 2011, DOI
• Zahedmanesh, H., Kelly, D.J., Lally, C. , Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy, Journal of Biomechanics, 43, (11), 2010, p2126-2132Journal Article, 2010, DOI
• Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. , Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography., Computers in Biology and Medicine, 40, (4), 2010, p419-429Journal Article, 2010, DOI
• Cell mechanics: The role of stimulation. In: Advances on modeling in tissue engineering. in, Computational Methods in Applied Science, 20, 1-14, Nova Publishers, 2011, [Jacobs, CR, Kelly DJ. ]Book Chapter, 2011
• Computational modelling in tissue engineering; providing light in times of darkness. in, editor(s)Alyssa D. Murphy , Computational Fluid Dynamics: Theory, Analysis and Applications, Nova Science Publishers., 2011, pp1 - 70, [McCoy, R., Kelly, DJ, O'Brien, F.J. ]Book Chapter, 2011
• C.T. Buckley, D.J. Kelly, Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs, Journal of the Mechanical Behavior of Biomedical Materials, 11, 2012, p102-111Journal Article, 2012, DOI , TARA - Full Text
• Cummins F, Reilly PO, Flannery O, Kelly D, Kenny P, Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty. A human cadaveric mechanical study., Acta Orthopaedica, 82, (4), 2011, p433-7Journal Article, 2011, DOI , URL , TARA - Full Text
• Ahearne M, Buckley CT, Kelly DJ, A growth factor delivery system for chondrogenic induction of infrapatellar fat pad-derived stem cells in fibrin hydrogels., Biotechnology and Applied Biochemistry, 58, (5), 2011, p345-352Journal Article, 2011, DOI
• Tatiana Vinardell, Rebecca A. Rolfe, Conor T. Buckley, Eric G. Meyer, Mark Ahearne, Paula Murphy and Daniel J. Kelly, Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells, European Cells and Materials, 23, 2012, p121 - 134Journal Article, 2012
• Nagel T, Kelly DJ, Mechanically induced structural changes during dynamic compression of engineered cartilaginous constructs can potentially explain increases in bulk mechanical properties., Journal of the Royal Society, Interface / the Royal Society, 9, (69), 2012, p777-89Journal Article, 2012, DOI , URL , TARA - Full Text
• Thomas Nagel, Daniel J. Kell, Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations, Journal of the Mechanical Behavior of Biomedical Materials, 9, 2012, p122-129Journal Article, 2012, DOI , URL , TARA - Full Text
• A.J. Steward, S.D. Thorpe, C.T. Buckley, D.R. Wagner, D.J. Kelly, Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure, Acta Biomaterialia, 8, (6), 2012, p2153-2159Journal Article, 2012, DOI , TARA - Full Text
• Eoghan Maher, Arthur Creane, Caitríona Lally, Daniel J. Kelly, An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue, Journal of the Mechanical Behavior of Biomedical Materials, 12, 2012, p9-19Journal Article, 2012, DOI , URL , TARA - Full Text
• T. E. Martin, D. J. Kelly, N. T. Keogh, D. Heriyadi, H. A. Singer & G. A. Blackburn, The avifauna of Lambusango Forest Reserve, Buton Island, south-east Sulawesi, with additional sightings from southern Buton, Forktail, 28, 2012, p107 - 112Journal Article, 2012
• Vinardell T, Rolfe RA, Buckley CT, Meyer EG, Ahearne M, Murphy P, Kelly DJ, Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells., European Cells & Materials, 23, 2012, p121-134Journal Article, 2012, DOI , URL , TARA - Full Text
• Thorpe SD, Buckley CT, Steward AJ, Kelly DJ, European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate., Journal of biomechanics, 45, (15), 2012, p2483-2492Journal Article, 2012, DOI , TARA - Full Text
• Haugh, M.G., Thorpe, S.D., Vinardell, T., Duffy, G.P. and Kelly, D.J. , The application of plastic compression to modulate fibrin hydrogel mechanical properties., Journal of the Mechanical Behavior of Biomedical Materials, 16, 2012, p66-72Journal Article, 2012, DOI
• Gannon AR, Nagel T, Kelly DJ, The role of the superficial region in determining the dynamic properties of articular cartilage., Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 20, (11), 2012, p1417-1425Journal Article, 2012, DOI , TARA - Full Text
• O'Heireamhoin S, Buckley CT, Jones E, McGonagle D, Mulhall KJ, Kelly DJ, Recapitulating Aspects of the Oxygen and Substrate Environment of the Damaged Joint Milieu for Stem Cell-Based Cartilage Tissue Engineering., Tissue engineering. Part C, Methods, 19, (2), 2013, p117-127Journal Article, 2013, DOI , TARA - Full Text
• Burke DP, Kelly DJ, Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: a mechanobiological model., PloS one, 7, (7), 2012, pe40737Journal Article, 2012, DOI , TARA - Full Text
• Boccaccio A, Kelly DJ, Pappalettere C, A model of tissue differentiation and bone remodelling in fractured vertebrae treated with minimally invasive percutaneous fixation., Medical & biological engineering & computing, 50, (9), 2012, p947-959Journal Article, 2012, DOI
• Liu Y, Buckley CT, Downey R, Mulhall KJ, Kelly DJ, The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad-derived stem cells., Tissue engineering. Part A, 18, (15-16), 2012, p1531-1541Journal Article, 2012, DOI , TARA - Full Text
• Vinardell T, Sheehy EJ, Buckley CT, Kelly DJ, A comparison of the functionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cell sources., Tissue engineering. Part A, 18, (11-12), 2012, p1161-1170Journal Article, 2012, DOI
• Maher E, Early M, Creane A, Lally C, Kelly DJ, Site specific inelasticity of arterial tissue., Journal of biomechanics, 45, (8), 2012, p1393-1399Journal Article, 2012, DOI , TARA - Full Text
• Buckley CT, Meyer EG, Kelly DJ, The influence of construct scale on the composition and functional properties of cartilaginous tissues engineered using bone marrow-derived mesenchymal stem cells., Tissue engineering. Part A, 18, (3-4), 2012, p382-396Journal Article, 2012, DOI , TARA - Full Text
• Sheehy EJ, Buckley CT, Kelly DJ, Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells., Biochemical and biophysical research communications, 417, (1), 2012, p305-310Journal Article, 2012, DOI
• Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations., Biomechanics and Modeling in Mechanobiology, 11, (6), 2012, p869-882Journal Article, 2012, DOI
• Kasiri, S., Kelly DJ. , An Argument for the Use of Multiple Segment Stents in Curved Arteries, Journal of Biomechanical Engineering, 133, (8), 2011, p084501Journal Article, 2011, DOI , TARA - Full Text
• Steward AJ, Wagner DR, Kelly DJ, The pericellular environment regulates cytoskeletal development and the differentiation of mesenchymal stem cells and determines their response to hydrostatic pressure., European cells & materials, 25, 2013, p167-178Journal Article, 2013, URL , TARA - Full Text
• Mesallati, T., Buckley, C.T., Nagel, T., Kelly, D.J., Scaffold architecture determines chondrocyte response to externally applied dynamic compression. , Biomechanics and Modeling in Mechanobiology, 12, (5), 2013, p889-899Journal Article, 2013, DOI
• Sheehy EJ, Vinardell T, Buckley CT, Kelly DJ, Engineering osteochondral constructs through spatial regulation of endochondral ossification., Acta biomaterialia, 9, (3), 2013, p5484-5492Journal Article, 2013, DOI , TARA - Full Text
• Nagel, T., Kelly, D.J. , The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture., Tissue Engineering Part A, 19, (7-8), 2013, 824-833Journal Article, 2013, DOI , TARA - Full Text
• Computational Mechanobiology in Cartilage and Bone Tissue Engineering: From Cell Phenotype to Tissue Structure in, Studies in Mechanobiology, Tissue Engineering and Biomaterials, Springer, 2012, pp341-377 , [Nagel, T., Kelly, D.J.]Book Chapter, 2012, DOI
• Patient Specific Computational Modeling in Cardiovascular Mechanics in, Patient-Specific Computational Modeling, 2012, pp61-79 , [A Creane, DJ Kelly, C Lally. ]Book Chapter, 2012, DOI
• Ahearne M, Kelly DJ, A comparison of fibrin, agarose and gellan gum hydrogels as carriers of stem cells and growth factor delivery microspheres for cartilage regeneration., Biomedical materials (Bristol, England), 8, (3), 2013, p035004Journal Article, 2013, DOI
• Thorpe SD, Nagel T, Carroll SF, Kelly DJ, Modulating Gradients in Regulatory Signals within Mesenchymal Stem Cell Seeded Hydrogels: A Novel Strategy to Engineer Zonal Articular Cartilage., PloS one, 8, (4), 2013, pe60764Journal Article, 2013, DOI , TARA - Full Text
• Burke, D., Dishowitz, M., Sweetwyne, M., Miedel, E., Hankenson, K.D., Kelly, D.J., The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice, Journal of Orthopaedic Research, 31, (10), 2013, 1585-1596Journal Article, 2013, DOI
• Nagel, T., Kelly, D.J., Altering the swelling pressures within in vitro engineered cartilage is predicted to modulate the configuration of the collagen network and hence improve tissue mechanical properties, Journal of the Mechanical Behavior of Biomedical Materials, 22, 2013, p22-29Journal Article, 2013, DOI
• Boccaccio, A., Kelly, D.J., Pappalettere, C., A mechano-regulation model to optimize design of minimally invasive percutaneous fixation devices for treatment of fractured vertebrae, Conference Proceedings of the Society for Experimental Mechanics Series, 2013 Annual Conference on Experimental and Applied Mechanics; , Lombard, IL; United States, 3-5 June, 3, 2014, pp93-98Conference Paper, 2014, DOI
• Nagel, T., Kolditz, O., Kelly, D.J., Enhanced poromechanical properties of tissue engineered cartilage via swelling induced collagen remodelling, Poromechanics V - Proceedings of the 5th Biot Conference on Poromechanics, 5th Biot Conference on Poromechanics, BIOT 2013;, Vienna, 10-12 July, 2013, pp2158-2165Conference Paper, 2013, DOI
• Steward, A.J., Wagner, D.R., Kelly, D.J., Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression, Journal of the Mechanical Behavior of Biomedical Materials , 2013Journal Article, 2013, DOI , TARA - Full Text
• Cilla, M., Peña, E., Martínez, M.A., Kelly, D.J., Comparison of the vulnerability risk for positive versus negative atheroma plaque morphology, Journal of Biomechanics , 46, (7), 2013, p1248-1254Journal Article, 2013, DOI
• Liu, Y., Buckley, C.T., Mulhall, K.J., Kelly, D.J., Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells, Biomaterials Science, 1, (7), 2013, p745-752Journal Article, 2013, DOI , TARA - Full Text
• Carroll, S.F., Buckley, C.T., Kelly, D.J., Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad. , Journal of Biomechanics, 47, (9), 2014, p2115 - 2121Journal Article, 2014, TARA - Full Text
• Rolfe RA, Nowlan NC, Kenny EM, Cormican P, Morris DW, Prendergast PJ, Kelly D, Murphy P., Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways., BioMedCentral Genomics, 15, 2014, p1 - 23Journal Article, 2014, TARA - Full Text
• Rolfe, RA, Nowlan, NC, Kenny, EM, Cormican, P, Morris, DW, Prendergast, PJ, Kelly, D, Murphy, P, Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways, BMC Genomics, 15, 2014, p48-Journal Article, 2014, DOI , TARA - Full Text
• Ahearne M, Liu Y, Kelly DJ, Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair, Tissue Engineering Part A, 20, (5-6), 2014, p930 - 939Journal Article, 2014, DOI , TARA - Full Text
• Sheehy EJ, Mesallati T, Vinardell T, Kelly DJ, Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels., Acta biomaterialia, 13, 2015, p245-253Journal Article, 2015, DOI , TARA - Full Text
• Steward AJ, Kelly DJ, Mechanical regulation of mesenchymal stem cell differentiation., Journal of anatomy, 227, (6), 2015, 717-731Journal Article, 2015, DOI
• Thompson EM, Matsiko A, Farrell E, Kelly DJ, O'Brien FJ, Recapitulating endochondral ossification: a promising route to in vivo bone regeneration., Journal of tissue engineering and regenerative medicine, 9, (8), 2015, p889-902Journal Article, 2015, DOI
• Almeida HV, Liu Y, Cunniffe GM, Mulhall KJ, Matsiko A, Buckley CT, O'Brien FJ, Kelly DJ, Controlled release of transforming growth factor-ß3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells., Acta biomaterialia, 10, (10), 2014, p4400-9Journal Article, 2014, DOI , TARA - Full Text
• Burke DP, Khayyeri H, Kelly DJ, Substrate stiffness and oxygen availability as regulators of mesenchymal stem cell differentiation within a mechanically loaded bone chamber., Biomechanics and modeling in mechanobiology, 14, (1), 2014, p93-105Journal Article, 2014, DOI , TARA - Full Text
• Liu Y, Buckley CT, Almeida HV, Mulhall KJ, Kelly DJ, Infrapatellar Fat Pad-Derived Stem Cells Maintain Their Chondrogenic Capacity in Disease and Can be Used to Engineer Cartilaginous Grafts of Clinically Relevant Dimensions., Tissue engineering. Part A, 20, (21-22), 2014, p3050-62Journal Article, 2014, DOI , TARA - Full Text
• Burke D, Dishowitz M, Sweetwyne M, Miedel E, Hankenson KD, Kelly DJ, The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice., Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31, (10), 2013, p1585-96Journal Article, 2013
• Sheehy EJ, Vinardell T, Toner ME, Buckley CT, Kelly DJ, Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation., PloS one, 9, (3), 2014, pe90716Journal Article, 2014, DOI , TARA - Full Text
• Steward AJ, Wagner DR, Kelly DJ, Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression., Journal of the mechanical behavior of biomedical materials, 38, 2014, p174-82Journal Article, 2014, DOI , TARA - Full Text
• Mesallati T, Buckley CT, Kelly DJ, A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes., Tissue engineering. Part C, Methods, 20, (1), 2014, p52-63Journal Article, 2014, DOI , TARA - Full Text
• Almeida, A.V, Cunniffe, G.M., Vinardell, T., Buckley, C.T., O'Brien, F.J., Kelly, D.J. , Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis. , Advanced Healthcare Materials, 4, (7), 2015, 1043-1053Journal Article, 2015, DOI , TARA - Full Text
• Gannon, A, Nagel, T., Kelly, D.J., Postnatal changes to the mechanical properties of articular cartilage are driven by the evolution of its collagen network, European Cells and Materials, 29, 2015, p105-123Journal Article, 2015, DOI , TARA - Full Text
• Steward,Andrew J. A.J., Kelly,Daniel John D.J., Wagner,Diane R. D.R., The role of calcium signalling in the chondrogenic response of mesenchymal stem cells to hydrostatic pressure, European Cells and Materials, 28, 2014, p358-371Journal Article, 2014
• Liu,Yurong Y., Buckley,Conor Timothy C.T., Almeida,Henrique V. H.V., Mulhall,Kevin J. K.J., Kelly,Daniel John D.J., Infrapatellar fat pad-derived stem cells maintain their chondrogenic capacity in disease and can be used to engineer cartilaginous grafts of clinically relevant dimensions, Tissue Engineering - Part A, 20, (21-22), 2014, p3050-3062Journal Article, 2014, DOI
• Mesallati,Tariq T., Buckley,Conor Timothy C.T., Kelly,Daniel John D.J., Engineering articular cartilage-like grafts by self-assembly of infrapatellar fat pad-derived stem cells, Biotechnology and Bioengineering, 111, (8), 2014, p1686-1698Journal Article, 2014, DOI
• Rolfe,Rebecca A. , Nowlan,Niamh C. , Kenny,Elaine M. , Cormican,Paul , Morris,Derek W. , Prendergast, Patrick J. ., Kelly, Daniel John ., Murphy, P., Identification of mechanosensitive genes during skeletal development: Alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways, BMC Genomics, 15, (1), 2014, p48-Journal Article, 2014, DOI , URL , TARA - Full Text
• Ahearne,Mark M., Liu,Yurong Y., Kelly,Daniel John D.J., Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair, Tissue Engineering - Part A, 20, (5-6), 2014, p930-939Journal Article, 2014, DOI

• Portmann D.; Huy P.T.B.; Aran J.M.; Blayney A.W.; Fraysse B.; Katz B.H.; Kelly D.J.; Prendergast P.J., The symphonix symposium understanding the ear advances in knowledge, Revue de Laryngologie Otologie Rhinologie, 121, (1), 2000, p65 - 72Journal Article
• McCartan B, Editorial, Journal of the Irish Dental Association, 21, 1975, p120 - 121Journal Article
• Mechanobiological Models of Skeletal Tissue Differentiation in, editor(s)Tomasz Lekszycki & Pawel Maldyk , Biomaterials in Orthopaedic Practice, Warsaw, Polish Academy of Sciences, 2005, pp49 - 68, [Kelly DJ]Book Chapter
• Modelling the response of cells to mechanical stimulation in, editor(s)Józef Joachim Telega , Modelling in Biomechanics, Warsaw, Polish Academy of Sciences, 2005, pp159 - 189, [Prendergast, PJ, Kelly, DJ, McGarry, JG]Book Chapter
• Kelly DJ., Linear elastic analysis and building a finite element model, Workshop of the European Society of Biomechanics, Dublin, Ireland, August 26-28, 2007Invited Talk
• Kelly DJ., Tissue differentiation steps towards bone formation., European Cells and Materials Conference on Bone Tissue Engineering,, Davos, Switzerland, June 25-28, 2007Invited Talk
• Kelly DJ., Mechanobiological models of skeletal tissue differentiation. , Biomaterials in Orthopaedic Practice Workshop, Warsaw, Poland, June , 2005Invited Talk
• Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010Oral Presentation
• Vinardell T, Thorpe S, Buckley C, Kelly D. , Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 15th Annual Conference of the Section of Bioengineering, Limerick, Ireland, edited by McGloughlin and M. Walsh , 2009Oral Presentation
• Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010Conference Paper
• Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010Invited Talk
• Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010Invited Talk
• Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010Invited Talk
• Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009Invited Talk
• Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009Invited Talk
• Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009Invited Talk
• Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009Invited Talk
• Kelly DJ., In vitro and in silico models of cell based therapies for cartilage repair , QUB Biomaterials Symposium & Workshop, Queens University Belfast, April 7, 2009Invited Talk
• Kelly DJ., Computational Modelling in the Design of Scaffolds for Bone and Cartilage Tissue Engineering., Institution of Mechanical Engineers Seminar: Computer Simulations in Medical Engineering, London, Nov 19, 2008Invited Talk
• Kelly DJ., Linear elastic analysis and building a finite element model, 2007 Workshop of the European Society of Biomechanics, Dublin, Ireland, August 26-28, 2007Invited Talk
• Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010Oral Presentation

Bone and cartilage tissue engineering My lab has demonstrated that it is possible to engineer zonal tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization (10.1371/journal.pone.0060764). We have demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process (10.1016/j.actbio.2012.11.008). We have also shown that it is possible to scale-up such developmentally inspired processes to regenerate large bone defects (10.1016/j.biomaterials.2018.01.057), or tissue engineer entire new bones (10.1089/biores.2015.0014) or biological implants for whole joint resurfacing (10.1016/j.biomaterials.2022.121750). To extend the utility of this strategy, we have used 3D bioprinting to engineer scaled-up hypertrophic cartilage templates for bone organ engineering (10.1002/adhm.201600182) and large bone defect repair (10.1016/j.actbio.2022.07.037). We have also used phenotypically distinct microtissues within microphysiological models of bone (10.1088/1758-5090/acd6be) and as biological building blocks for the biofabrication of osteochondral grafts for synovial joint regeneration (10.1016/j.biomaterials.2022.121750). Single stage strategies for bone and cartilage repair In 2010 I was awarded a European Research Council (ERC) starter grant to develop novel stem cell based therapies to regenerate damaged articular cartilage. To realise the goals of this project, we first developed a range of decellularized extracellular matrix (ECM) derived scaffolds for articular cartilage (10.1016/j.actbio.2014.05.030 & 10.1016/j.mtbio.2022.100343), bone (10.22203/eCM.v033a10) and osteochondral defect repair (10.1016/j.biomaterials.2018.09.044 & 10.1016/j.actbio.2022.03.009), and have tested these scaffolds in relevant pre-clinical animal models. We have also demonstrated that the source tissue of ECM scaffolds plays a key role in regulating the phenotype of both macrophages and skeletal stem cells (10.1016/j.regen.2021.100041). We recently completed an ERC proof-of-concept to address challenges with the clinical translation of this project (10.1016/j.mtbio.2022.100343), and have recently established a TCD spin-out company (in partnership with NLC Health) to move this technology into the clinic. 3D (bio)printing for the regeneration of musculoskeletal tissues In recent years we have utilised emerging biofabrication and bioprinting strategies to engineer prevascularised implants for bone repair (10.1016/j.actbio.2021.03.003) and structurally organised articular cartilage (10.1016/j.biomaterials.2018.12.028 & 10.1016/j.biomaterials.2022.121405) and meniscus tissue (10.1016/j.actbio.2022.12.047). As part of my ERC consolidator grant, we modified such inks for gene (10.1016/j.jconrel.2019.03.006 & 10.1089/ten.tea.2016.0498) and growth factor (10.1016/j.actbio.2021.04.016 & 10.1038/s41598-017-17286-1) delivery. Furthermore, we bioprinted implants containing spatiotemporally defined patterns of growth factors and demonstrated that printed constructs containing a gradient of VEGF, coupled with spatially defined BMP-2 localization and release kinetics, accelerated large bone defect healing 10.1126/sciadv.abb5093). We have also used 3D printing techniques to produce fibre-reinforced cartilaginous templates, and assessed the efficacy of such constructs in a caprine model of osteochondral defect repair (10.1016/j.actbio.2020.05.040). We have also demonstrated how emerging additive manufacturing techniques such as melt electrowriting (10.1016/j.addma.2022.102998) can be used to produce scaffolds capable of directing angiogenesis and the regeneration of large bone defects (10.1088/1758-5090/ac88a1 & 10.1002/adhm.202302057).

• Title

  PreclinicAl Infrastructure Resource
  Summary

  A significant investment has been made in Ireland in the research underpinning the development of new medical devices and implants to treat a range of diseases - from heart failure to arthritis. In order to commercialise this basic research and to ensure its translation into the clinic, there is a clear need for improved pre-clinical facilities to assess the safety and efficacy of these new approaches. This project will enable the development of a state of the art surgical facility for the pre-clinical evaluation of Advanced Therapeutic Medicinal Products (ATMPs) and next generation medical devices.
  Funding Agency

  Science Foundation Ireland
  Date From

  Jan 2017
  Date To

  Dec 2018
• Title

  Engineering structurally anisotropic and mechanically functional musculoskeletal tissues by guiding the fusion, differentiation and (re)modelling of stem cell derived cartilage spheroids
  Summary

  Regeneration of musculoskeletal tissues requires engineered grafts that mimic the heterogeneous and anisotropic structure and mechanics of the native tissue. The goal of this project is to leverage emerging biofabrication technologies to provide physical boundary conditions and spatially localised morphogens to (stem cell derived) cartilage spheroids to guide their fusion and (re)modelling to engineer truly biomimetic articular cartilage. To realise this goal, this project will build upon applicant"s extensive expertise in bioprinting and bioink development to produce a new biofabrication platform that provides physical boundaries, matrix (re)modelling factors and spatiotemporally defined patterns of growth factors to self-organizing cellular aggregates, microtissues or organoids. To demonstrate the utility of this biofabrication platform it will be used to engineer articular cartilage grafts that mimic the depth-dependant structure, composition and mechanical properties of the native tissue. The ability to bioprint such functional tissues will transform the field of orthopaedic medicine, providing grafts to biologically resurface large areas of damaged synovial joints and thereby prevent the development of osteoarthritis " a debilitating disease affecting millions of people worldwide. The impact this project will not be limited to the orthopaedic space, as it is envisioned that these new bioprinting platforms will find numerous applications in regenerative medicine.
  Funding Agency

  Science Foundation Ireland
• Title

  A new constitutive framework to investigate the role of mechanical forces on protein synthesis and organization during differentiation of mesenchymal progenitor cells
  Summary

  It is believed that the mechanical environment of mesenchymal stem cells can influence their differentiation pathway. A number of different hypotheses have been proposed which describe how mechanical forces can regulate this pathway. It has been possible to test many of these ideas by encapsulating the hypothesis into an algorithm, and then conducting 'numerical experiments' to determine if the hypotheses on which the algorithm is based can predict realistic patterns of tissue differentiation. It is still unclear as to how the mechanical properties of tissues change during the differentiation process due to changes in protein synthesis, assembly, cross-linking, orientation etc. The hypothesis under investigation here is that mechanical forces regulate protein synthesis and organization during the differentiation of cells of the mesenchymal lineage, and hence the resulting mechanical properties of the differentiating tissue.
  Funding Agency

  IRCSET
  Date From

  2008
  Date To

  2012
• Title

  Mini Stents: A novel stent system consisting of multiple, independent stents delivered from a single device
  Summary

  While successful in preventing elastic recoil following balloon angioplasty, stenting results in increased injury and ultimately restenosis in 10-40% of cases. Complication rates are higher in long and tortuous vessels, in many cases due to the inability of a relatively stiff stent to conform to the vessel's curvature. The objective of this project is design a novel stent system that can comply with any vessel wall, regardless of its tortuosity, thereby minimising vessel injury.
  Funding Agency

  Enterprise Ireland
  Date From

  2006
  Date To

  2008
• Title

  CarBon - Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis
  Summary

  Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. Understanding and controlling the dual character of cartilage is pivotal: insufficient transition impairs bone healing, and undesired transition to bone leads to osteoarthritis. In CarBon, state of the art in vitro, in silico and in vivo models will be uniquely combined to elucidate how this transition is orchestrated and how it can be modulated. In a multifactorial approach, a network of 14 young scientists will aim to identify the biological and physical factors that determine the fate of cartilage. Knowledge from the fields of tissue engineering, cartilage and bone developmental biology and pathobiology will be combined with skills from the disciplines of cell biology, computational modelling, biotechnology (bioreactors, biomaterials) and drug discovery.
  Funding Agency

  H2020
  Date From

  Jan 2017
  Date To

  Dec 2020
• Title

  Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports
  Summary

  Osteoarthritis (OA), the most common form of arthritis, is a serious disease of the joints affecting nearly 10% of the population worldwide. The onset of OA has been associated with defects to articular cartilage that lines the bones of synovial joints. Current strategies to treat articular cartilage defects are ineffective and/or prohibitively expensive. The aim of ANCHOR is to develop and commercialise a new medicinal product for articular cartilage regeneration that recruits endogenous bone marrow derived stem cells into an extracellular matrix derived scaffold anchored to the subchondral bone by 3D printed polymeric supports. By recruiting endogenous cells into a supporting scaffold, ANCHOR will obviate the need for pre-seeding scaffolds with cells prior to implantation into cartilage defects, thereby dramatically reducing the cost and complexity of the repair procedure. It will also overcome the need for suturing of a scaffold into a cartilage defect, which is a very time consuming and technically challenging surgical procedure. Finally, the inherent chondro-inductivity of the cartilage ECM derived scaffolds developed by the applicant will maximise the potential for hyaline cartilage regeneration. The project will leverage the applicants extensive experience in ECM derived biomaterials and 3D printing to develop a new product with significant commercial potential. The impact of ANCHOR will be multi-faceted: it will transform how damaged joints are treated by orthopaedic surgeons, it will create economic value through the commercialization of IP, and most importantly it will improve patient experience and their long-term health and well-being.
  Funding Agency

  European Research Council
  Date From

  Jan 2018
  Date To

  June 2019
• Title

  Porous decellularized hypertrophic tissue engineered cartilage as a scaffold for large bone defect healing
  Summary

  Most bones develop by endochondral ossification, the replacement of hypertrophic cartilaginous templates with bone. It has recently been demonstrated that adult human bone marrow derived mesenchymal stem cells (MSCs) can be used to engineer cartilaginous tissues that act as a template for bone formation in vivo21. While conceptually appealing as a treatment option for bone regeneration, clinical translation of any cell-based therapy is hampered by high costs and significant regulatory challenges. The hypothesis of this proposal is that a porous scaffold derived from decellularized hypertrophic cartilage engineered using allogenic bone marrow derived MSCs will be highly osteoinductive, support vascularisation, allow osteoclastic resorption and will promote bone formation by host progenitor cells. This scaffold will be compared to a highly porous collagen-hydroxyapatite scaffold which has been designed specifically for bone repair. The scaffold will be evaluated by demonstrating its ability to induce ectopic bone formation in a subcutaneous nude mouse model. If proven effective, such a treatment option would provide an off-the-shelf solution for the treatment of large bone defects.
  Funding Agency

  AO Foundation
  Date From

  01/01/2012
  Date To

  31/12/2013
• Title

  OPTIMIZING THE DESIGN OF PERIPHERAL STENTS USING FINITE ELEMENT MODELLING
  Summary

  Peripheral vascular disease (PVD) is a condition in which there is insufficient blood flow through the arms or legs, causing pain, cramping or heaviness in the muscle. Causes of PVD include atherosclerosis, scar tissue and blood clots. In patients with PVD, balloon angioplasty, with or without stenting, may be used to open up a blocked iliac or femoral artery that supplies blood to the leg; however the procedural and long-term success of peripheral stenting has been inferior to coronary stenting. Restenosis rates are high, and technical difficulties have been encountered with delivering these large stents from a balloon catheter. The objective of this project is to use finite element modelling to understand how the design of a peripheral stent influences (i) its deployment from a balloon, and (ii) the stresses developed in the vessel wall, which are known to influence restenosis rates. Ultimately the objective if this project will be to optimise the design of a peripheral stent so that it can be deployed successfully from a balloon catheter and will minimise the stresses generated in the vessel wall.
  Funding Agency

  Enterprise Ireland
  Date From

  2005
  Date To

  2007
• Title

  A decellularised extracellular matrix derived scaffold incorporating freshly isolated joint tissue derived cells as a bioactive implant for cartilage repair. (CF/2014/4325)
  Summary

  We have developed a new 'single-stage' or 'off-the-shelf' approach to articular cartilage regeneration that consists of a chondro-inductive extracellular matrix (ECM) derived scaffold seeded with freshly isolated joint tissue derived stromal cells that are processed 'in-theatre'. The primary objective of this project is to evaluate the efficacy of this 'single-stage' or 'in-theatre' therapy for articular cartilage regeneration in a large animal model study.
  Funding Agency

  Enterprise Ireland
  Date From

  2014
  Date To

  2017
• Title

  3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration. (ERC-2014-CoG -647004)
  Summary

  Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide 'off-the-shelf', patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate anatomically accurate, biomimetic constructs that can be used to regenerate both the cartilage and bone in a diseased joint. If successful, such an implant would form the basis of a truly transformative therapy for treating degenerative joint disease.
  Funding Agency

  European Research Council
  Date From

  2015
  Date To

  2020
• Title

  Development of a method to predict which carotid plaques will rupture using Computerised Tomographic Angiography(CTA) and Duplex Ultrasound(US) with Grey-Scale Median imaging, numerical modelling, tissue testing and human serum markers
  Summary

  Many atherosclerotic plaques form in arteries, some cause stenosis and symptoms of ischemia, whilst others lie in regions of expansive remodelling unrestricting blood flow. It is these vulnerable plaques that can be prone to sudden rupture and lead to an acute stroke or sudden death without warning. The aim of this project is therefore to identify the key characteristics normally associated with vulnerable carotid plaques, such as geometry and plaque material properties using CTA and Duplex US with GSM imaging techniques. It is then proposed to use these images to generate 3-D realistic numerical models of the vessel to estimate the stresses in the plaque under physiological loading conditions
  Funding Agency

  Science Foundation Ireland
  Date From

  2007
  Date To

  2010
• Title

  Printing spatially and temporally defined boundaries to direct the self-organization of cells and cellular aggregates to engineer functional tissues
  Summary

  Regeneration of musculoskeletal tissues requires engineered grafts that mimic the heterogeneous and anisotropic structure and mechanics of the native tissue. Despite decades of research, existing regenerative strategies have failed to produce tissues mimicking this exquisite structural complexity, dramatically limiting their clinical utility. Clues to addressing this grand challenge can be found in normal tissue development, which relies upon both the self-organizing potential of stem cells as well as key physical instructions from the microenvironment to establish final tissue architectures. Recognising this, the goal of 4D-BOUNDARIES is to leverage emerging 3D bioprinting technologies to provide precise physical boundary conditions and spatially localised morphogens to self-organizing cells and cellular aggregates to engineer structurally anisotropic and mechanically functional musculoskeletal tissues. To realise this goal, 4D-BOUNDARIES will build upon applicant"s extensive expertise in bioprinting and bioink development to produce two new biofabrication platforms that provide temporary guiding structures to self-organizing tissues. To demonstrate the utility of these bioprinting platforms they will be used to engineer, for the first time, patient-specific cartilage and meniscal grafts that mimic the internal and external anatomy and anisotropic mechanical properties of the native tissues. The ability to bioprint such functional tissues will transform the field of orthopaedic medicine, providing grafts to biologically resurface large areas of damaged articular cartilage and meniscus and thereby prevent the development of osteoarthritis " a debilitating disease affecting millions of people worldwide. The impact of 4D-BUNDARAIRES will not be limited to the orthopaedic space, as it is envisioned that these new bioprinting
  Funding Agency

  European Research Council
  Date From

  2021
  Date To

  2026
• Title

  Design and Manufacture of a Novel Bone-Protecting Handheld Distractor.
  Summary

  Orthopaedic bone spreaders (distractors) are surgical instruments designed for the distraction and holding apart of segments of bone and are commonly used surgical tool. Existing versions are rigid and non-jointed steel instruments which have a tendency to cut or dig into or otherwise crush or damage bone along their edges or corners, especially when placed between angled or nonparallel surfaces. Our aim is to construct a instrument which is surface conforming and evenly applies its contact stress This is intended as being protective of the pathologically fragile bone of osteoporosis which is specifically vulnerable to the kind of intra-operative damage existing instruments can inflict.
  Funding Agency

  Enterprise Ireland
  Date From

  2007
  Date To

  2008
• Title

  Mechanobiology of mesenchymal stem cells for articular cartilage repair
  Summary

  Mesenchymal stem cells (MSCs) have the ability to differentiate into distinctive end-stage cell types, such as those that synthesise specific mesenchymal tissues including cartilage, bone, tendon and muscle. MSCs have a number of advantages over primary chondrocytes for cartilage repair, including their ease of expansion and maintenance of phenotype. It has been shown that MSCs isolated from patients with knee OA show greater chondrogenic capability than primary chondrocytes obtained from articular cartilage biopsies from the same OA joints. However the clinical use of MSCs is restricted by insufficient knowledge of how the environment such cells will experience in vivo will influence the long-term stability of the repair tissue. The objective of this research is to provide a better understanding of how the mechanical loading experienced by MSCs or engineered tissues in vivo will influence their differentiation pathway and the quality and type of tissue they produce. Furthermore we wish to investigate whether the mechanical properties of scaffolds used to provide functional support to implanted cells can be optimised to promote and enhance chondrogenesis of the repair tissue.
  Funding Agency

  Science Foundation Ireland
  Date From

  2008
  Date To

  2013
• Title

  A novel device to control in situ the thermal gelation and concentration of cell-seeded hydrogels
  Summary

  It is believed that injuries to cartilage predispose a person to osteoarthritis in later life and eventually to a requirement for joint replacement surgery. Injectable chondrocyte-seeded hydrogels can potentially be used to fill cartilage defects with a functional repair tissue. Ensuring that the hydrogel has the appropriate mechanical properties in situ (e.g. stiffness, permeability, porosity) is critical for successful repair. The objective of this project is to develop a clinical device capable of controlling the hydrogel concentration and the rate of cooling during gelation in situ, which can be used to alter the depth dependant mechanical properties of the construct.
  Funding Agency

  Enterprise Ireland
  Date From

  2007
  Date To

  2009
• Title

  Melt Electrowriting of Multi-layered Scaffolds for osteochondral defect repair
  Summary

  An osteochondral (OC) defect is a focal area of joint damage that involves both the articular cartilage and the underlying subchondral bone. Such joint damage is strongly associated with the development of premature osteoarthritis, motivating the development of novel strategies to regenerate OC defects. 3D printing is enabling the manufacturing of geometrically complex biomaterial implants with user defined compositions and architectures, which can potentially be used as single stage, off-the-shelf scaffolds for treating complex injuries. Despite significant progress in this field, 3D printed scaffolds capable of regenerating OC defects remain elusive. This can potentially be linked to the spatial resolution possible using traditional additive manufacturing techniques. The melt electrowriting (MEW) technique has recently emerged as a novel additive manufacturing platform capable of producing polymeric scaffolds with fiber diameters in the submicron range in a highly controllable manner. We have recently developed MEW scaffolds that support superior bone regeneration compared to scaffolds produced using traditional additive manufacturing techniques. Furthermore, we have generated preliminary data demonstrating that multi-layered scaffolds generated by MEW are capable of enhancing the repair of critically sized OC defects in a pre-clinical large animal model. The MEMS project aims to further enhance the regenerative capacity of these MEW OC scaffolds by (i) optimising their architecture, and (ii) functionalizing their surface with extracellular matrix (ECM) components supportive of tissue-specific regeneration. The output of MEMS will be an off-the-shelf implant capable of directing endogenous OC defect regeneration without the need for delivering exogenous cells to the defect site.
  Funding Agency

  European Research Council
  Date From

  2023
  Date To

  2025
• Title

  The influence of biophysical stimuli on tissue differentiation and matrix synthesis in vitro.
  Summary

  Recent in vitro studies have demonstrated that both chondrogenesis and osteogeneis of bone marrow-derived mesenchymal stem cells (MSCs) can be induced using specific growth factors. Mechanical loading is known to influence the biosynthetic activity of osteoblasts and chondrocytes, however the effects of mechanical stimulation on regulating the differentiation pathway of MSCs remains unclear. The question that this proposal wishes to addresses is whether cartilage and bone like tissues can be selectively engineered using the same scaffold type and the same cell type (marrow-derived MSCs) by varying the mechanical environment of the cells.
  Funding Agency

  Science Foundation Ireland
  Date From

  2007
  Date To

  2010
• Title

  Design and development of a novel device to control the fabrication, confined compression and in situ delivery of cell-seeded collagen gel scaffolds
  Summary

  Tissue engineering strategies offer a potential solution for cartilage defect repair, however results to date have been mixed. Delivering a functional cell-seeded construct to the defect site would appear to be critical for successful cartilage repair. Recently it has been shown that plastic compression of collagen gel scaffolds leads to significant increase in the mechanical properties of the scaffold. The objective of this project is to develop a hand-held clinical device to control the gelation and levels of confined compression applied to cell-seeded collagen gels prior to implantation. By controlling the rate and magnitude of the confined compression, it is hypothesised that a gradient scaffold with depth dependant mechanical properties similar to normal articular cartilage can be fabricated and delivered directly to the defect site
  Funding Agency

  Enterprise Ireland
  Date From

  2008
  Date To

  2009
• Title

  A tissue engineered biological joint replacement prosthesis for the treatment of degenerative joint disease (12/IA/1554)
  Summary

  Realising an efficacious therapeutic solution for treating osteoarthritis remains elusive and is considered one of the greatest challenges in the field of orthopaedic medicine. Tissue engineering aims to replace or regenerate damaged or diseased tissues through the combined use of cells, scaffolds and physio-chemical cues. The aim of this proposal is to tissue engineer a biological joint replacement prosthesis using mesenchymal stem cells (MCSs) as the basis of a novel therapy for treating degenerative joint disease. This will be achieved in part by recapitulating key aspects of normal bone and joint development, specifically the process of endochondral ossification where a hypertrophic cartilaginous intermediary is replaced by bone. The first phase of the project will attempt to tissue engineer a hypertrophic cartilaginous construct using MSCs that mimics the anatomy of the knee joint and then demonstrate that such a construct will be replaced by bone in vivo. The second phase of the project will use MSCs to engineer a stable layer of articular cartilage on the surface of the hypertrophic construct. The final phase of the project will evaluate the potential of the proposed biological prosthesis to regenerate both the articular cartilage and underlying bone of the medial femorotibial joint.
  Funding Agency

  Science Foundation Ireland
  Date From

  2013
  Date To

  2018
• Title

  Novel mesenchymal stem cell based therapies for articular cartilage repair
  Summary

  Once damaged articular cartilage has a limited reparative capacity and thus lesions often progress to arthritis. This has motivated the development of cell based therapies for the repair of cartilage defects such as autologous chondrocyte implantation (ACI). Such therapies are limited in two ways. Firstly, they do not result in the regeneration of hyaline cartilage and hence the repair is temporary. Secondly, widespread adaptation into the clinical setting is impeded by practical issues such as the high cost and time required for culture expansion of chondrocytes. The applicant is of the belief that both issues cannot currently be addressed by a single new therapy. Therefore the proposed project will put forward separate solutions to both issues. The first theme of the project will determine whether freshly isolated (not culture expanded) infrapatellar fat pad derived cells, embedded in a hydrogel containing microbead-encapsulated growth factors, can used to engineer functional cartilage tissue. A component of this theme will involve magnetic microbead selection for cells with surface markers associated with mesenchymal stem cells (MSCs). Theme 2 of the proposed project will explore an alternative therapy for cartilage defect repair. Specifically, the objective is to tissue engineer in vitro a functional tissue with a zonal structure mimicking that of normal articular cartilage using MSCs. It is hypothesised that such a zonal structure can be generated by controlling the oxygen tension and mechanical environment within the developing tissue. The final theme of the project will be to determine if repairing high-load bearing cartilage defects using such tissue engineered grafts will result in significantly improved repair compared to ACI.
  Funding Agency

  European Research Council
  Date From

  2010
  Date To

  2015
• Title

  Computational modelling of in-stent restenosis
  Summary

  The major limitation of angioplasty with or without stenting is restenosis of the target vessel. There are a number of possible mechanisms responsible for restenosis, including neointimia formation and negative remodelling due to uncontrolled cell proliferation, migration and matrix synthesis following injury to the vessel wall. Drug-eluting stents have been successful in reducing the incidence of restenosis by targeting some (but not all) of the biological processes contributing to the condition, although even their effectiveness has recently been queried. The objective of this project is to develop a computational model of the biochemical and physical mechanisms responsible for in-stent restenosis.
  Funding Agency

  Irish Research Council for Science, Engineering and Technology
  Date From

  2006
  Date To

  2009

• Industry Engagement Award at the Trinity College Dublin Innovation Awards 2021
• Membership of the Royal Irish Academy. 2024
• Fellow of Trinity College Dublin 2010
• Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008
• European Research Council Consolidator Award 2015
• European Research Council Starter Award, 2010
• Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
• Mid-term career award from the Tissue Engineering and Regenerative Medicine International (TERMIS) EU society 2023
• Science Foundation Ireland Industry Partnership Award 2019
• Norman Gamble Award in Otology 2002
• Silver Medal, Royal Academy of Medicine in Ireland (Bioengineering Division) 2022
• European Research Council Proof of Concept Grant 2017
• Hewlett Packard Prize 1999
• One-2-Watch Award at the Trinity College Dublin Innovation Awards 2018
• Fulbright Award 2009
• European Research Council Advanced Award 2021

• Honorary Associate Professor, Royal College of Surgeons in Ireland. 2014 -
• Affiliate Associate Professor, Colorado State University, USA. 2014 -
• Honorary Associate Professor, Royal College of Surgeons in Ireland. 2014 -
• Affiliate Associate Professor, Colorado State University, USA. 2014 -