Unnatural DNA analogues for enhanced stability and new functionality

DNA damage repair enzymes play crucial roles in cell maintenance. These enzymes play critical roles in DNA repair, immune system development and telomere maintenance. We aim to create tools based on modified DNA structures to study these key enzymes.

These tools will lead to a greater understanding of the activity and function of DNA damage repair enzymes in a cellular context. This understanding will underpin and enable research into accelerated aging, cures for developmental defects caused by enzymatic dysfunction, and more effective DNA interstrand cross-linking cancer therapies.