Welcome to the Martin Lab
Trinity College Dublin

Sullivan, G. P., Davidovich, P., Muñoz-Wolf, N., Ward, R. W., Hernandez Santana, Y. E., Clancy, D. M., ..., SJ Martin (2022) Myeloid cell–derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement. Science Immunology 7,78: eade5728.

Frezza, V., Najda, Z., Davidovich, P., Sullivan, G. P. Martin SJ (2022) IL-1α and IL-36 family cytokines can undergo processing and activation by diverse allergen-associated proteases Frontiers in Immunology 13, 3331.

Martin SJ, Frezza, V., Davidovich, P., Najda, Z., & Clancy, D. M, (2022) IL-1 family cytokines serve as activity recognition receptors for aberrant protease activity indicative of danger Cytokine 157, 155935.

Sullivan, G. P., O’Connor, H., Henry, C. M., Davidovich, P., Clancy, D. M., Albert, M. L., ..., Martin SJ (2020) TRAIL receptors serve as stress-associated molecular patterns to promote ER-stress-induced inflammation Developmental Cell 714-730.

Clancy, D. M., Sullivan, G. P., Moran, H. B., Henry, C. M., Reeves, E. P., McElvaney, N. G., ..., Martin SJ (2018) Extracellular neutrophil proteases are efficient regulators of IL-1, IL-33, and IL-36 cytokine activity but poor effectors of microbial killing Cell Reports 22, 2937-2950.

Kearney CJ and Martin SJ (2017) An Inflammatory Perspective on Necroptosis. Molecular Cell 65, 965-973.

Henry CM and SJ Martin (2017) Caspase-8 acts in a Non-Enzymatic Role as a Scaffold for assembly of a pro-inflammatory 'FADDosome' complex in response to TRAIL stimulation. Molecular Cell 65, 715-729.

Henry CM, Sullivan GP, Clancy DM, Afonina IS, Kulms D, and SJ Martin. (2016) Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines. Cell Reports 14, 708-22.

Afonina IS, Müller C, Martin SJ, Beyaert R. (2015) Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme. Immunity 42, 991-1004.

Cullen SP, Kearney CJ, Clancy DM, and SJ Martin (2015) Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis. Cell Reports 11, 1535-48.

Hollville, E., Carroll, R. and S.J. Martin (2014) Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy. Molecular Cell 55, 451-466.

Carroll, R., Hollville, E. and S.J. Martin (2014) Parkin sensitizes towards apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell Reports, 9, 1538-53.

Carroll, R. and S. J. Martin (2013) Autophagy and Multiple Myeloma: What makes you Stronger Can Also Kill you. Cancer Cell, 23, 425-6.

Cullen, SP, Henry CM, Kearney, CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, and Martin SJ (2013) Fas/CD95-Induced Chemokines can Serve as 'Find-Me' Signals for Apoptotic Cells. Molecular Cell, 49, 1034-1048.

Hollville, E. and S.J. Martin (2012) Greasing the path to Bax/Bak activation and apoptosis. Cell 148, 845-846.

Martin SJ, Henry CM, Cullen SP. (2012) A perspective on mammalian caspases as positive and negative regulators of inflammation. Molecular Cell 46, 387-97

Martin, S.J. (2010) Opening the cellular poison cabinet. Science 330, 1330-1331.

Elgendy, M., Sheridan, C., Brumatti, G. and S.J Martin (2011) Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival. Molecular Cell 42, 23-35.

Cullen, S.P., Henry, C.M. and S. J. Martin (2011) Staying alive: defensive strategies in the Bcl-2 family playbook. Molecular Cell 44, 509-510.

Afonina, I.A., Tynan, G.A., Logue, S. E., Cullen, S.P., Bots, M., Lüthi, A. U., Reeves, E. P., McElvaney, N. G., Medema, J. P., Lavelle, E. C. and S.J. Martin (2011) Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1α. Molecular Cell, 44, 265-278.

Lüthi, A.U., Cullen, S.P., McNeela, E.A., Duriez, P.J., Afonina, I.S., Sheridan, C., Brumatti, G., Taylor, R.C., Kersse, K., Vandenabeele, P., Lavelle, E.C. and S. J. Martin. (2009) Suppression of IL-33 Bioactivity through Proteolysis by Apoptotic Caspases. Immunity, 31, 84-98.

Autret, A. and S.J. Martin. (2009) Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Molecular Cell, 36, 355-363

Taylor, R. C, Cullen, S. P. and S.J. Martin. (2008) Apoptosis: demolition at the cellular level. Nature Reviews, Molecular & Cell Biology 9, 231-241.

Sheridan, C., Delivani, P., Cullen, S .P. & S.J. Martin (2008) Bax or Bak-dependent mitochondrial fission can be uncoupled from cytochrome c release. Molecular Cell 31, 570-585.

Cullen S.P., Adrain, C., Luthi, A. U., Duriez, P. J., and S.J. Martin. (2007) Human and Murine Granzyme B Exhibit Divergent Substrate Preferences. Journal of Cell Biology, 176, 435.

Delivani, P., Adrain, C., Taylor, RC., Duriez, P.J & S.J. Martin (2006) Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Molecular Cell 21, 761-773.