Professor Seamus Martin
Smurfit Professor of Medical Genetics, Genetics
Biography
Seamus Martin holds the Smurfit Chair of Genetics at Trinity College Dublin, Ireland (since 1999). He was elected to The Royal Irish Academy in 2006, to the European Molecular Biology Organization (EMBO) in 2009 and to Academia Europaea in 2023. He served as President of the European Cell Death Organization (ECDO) from 2016-2018 and was awarded an ERC Advanced grant in 2021. He co-wrote (with Pete Delves, Dennis Burton and Ivan Roitt) the 11th, 12th and 13th Editions of the classic undergraduate Immunology textbook `Essential Immunology" and has served as Editor-in-Chief of The FEBS Journal (Cambridge, UK), an international life sciences journal, since 2014 to present.
The Martin laboratory is interested in all aspects of programmed cell death, especially the links between cell death, inflammation and cancer. Some key papers: Introduction of annexin V-labelling, the gold standard for measuring apoptosis (Martin et al., 1995 J. Exp. Med.), Unravelling the apoptosis-associated caspase activation cascade (Slee et al., 1999 J. Cell Biol.), Oncogenic Ras promotes autophagic cell death (Elgendy et al., 2011 Molecular Cell), Apoptotic cells can be pro-inflammatory (Cullen et al., 2013 Molecular Cell; Henry et al., 2017 Molecular Cell), Parkin activation can promote apoptosis (Hollville et al., 2014 Molecular Cell; Carroll et al., 2014 Cell Reports) Discovery of the mechanism of activation of the IL-36 cytokine family (Henry et al., 2016 Cell Reports; Clancy et al., 2018 Cell Reports); ER Stress promotes inflammation via TRAIL receptors (Sullivan et al., 2020 Developmental Cell); IL-37 is pro-inflammatory via IL-36 receptor engagement (Sullivan et al., 2022 Science Immunology).
Necrotic cell death either instigates inflammation (in sterile injury contexts) or is a key amplifier of inflammation (during infection). In both scenarios, molecules released from dead cells (collectively called DAMPs, damage-associated molecular patterns) trigger inflammation. However, exactly what constitutes a DAMP has been the subject of much debate. We are currently exploring the idea that members of the extended IL-1 family constitute the key DAMPs and how IL-1 family cytokines become activated/inactivated. We are also actively exploring how cell stress (e.g. due to chemotherapy) triggers inflammation.
Editor-in-Chief of The FEBS Journal (since Jan 2014-present) Current and previous Editorial Board memberships: Cell Reports (Cell press), Science Signaling (AAAS), Oncogene (Deputy editor & Receiving Editor), The Journal of Biological Chemistry, Cell Death and Differentiation (Nature Publishing Group), Oncogenesis (Nature Publishing Group). "FEBS Open Bio (FEBS Press).
National and international awards: Wellcome Trust Prize Fellowship Award (1994-1996) Wellcome Trust Senior Fellow Award (1996-2001) Science Foundation Ireland Awards (2002-07, 2008-14, 2015-20) The BA Charles Darwin Award (2005) The GlaxoSmithKline Award of The Biochemical Society UK (2006) Elected to The Royal Irish Academy (2006) Elected to the European Molecular Biology Organization (EMBO) in 2009 The Boyle Medal (2015), Ireland"s highest scientific honor, awarded every 4 years. The ICDS Medal (2016), The major biannual award from the International Cell Death Society. European Research Council (ERC) Advanced Grant Awardee 2021-present Elected to Academia Europaea, 2023
Publications and Further Research Outputs
Peer-Reviewed Publications
Sullivan, G.P. and Davidovich, P. and Muñoz-Wolf, N. and Ward, R.W. and Hernandez Santana, Y.E. and Clancy, D.M. and Gorman, A. and Najda, Z. and Turk, B. and Walsh, P.T. and Lavelle, E.C. and Martin, S.J., Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement, Science immunology, 7, (78), 2022, peade5728
Wladek Minor, Mariusz Jaskolski, Seamus J. Martin, Zbigniew Dauter, Dr. Alexander Wlodawer"celebrating five decades of service to the structural biology community, The FEBS Journal, 288, (14), 2021, p4160--4164
Emir Bozkurt, Heiko Düssmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn, TRAIL signalling promotes entosis in colorectal cancer, 2020
Boeltz S, Amini P, Anders H.-J, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy D.M, Desai J, Dumych T, Dwivedi N, Gordon R.A, Hahn J, Hidalgo A, Hoffmann M.H, Kaplan M.J, Knight J.S, Kolaczkowska E, Kubes P, Leppkes M, Manfredi A.A, Martin S.J, Maueröder C, Maugeri N, Mitroulis I, Munoz L.E, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic M.Z, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik M.J, Simon H.-U, Skendros P, Stojkov D, Vandenabeele P, Berghe T.V, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M, To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps, Cell Death and Differentiation, 26, (3), 2019, p395 - 408
Martin S.J, The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled, FEBS Journal, 286, (1), 2019, p4 - 7
Gemayel R, Martin S.J, How to prepare and deliver a great talk, FEBS Journal, 286, (1), 2019, p39 - 45
Sullivan, G.P. and Davidovich, P.B. and Sura-Trueba, S. and Belotcerkovskaya, E. and Henry, C.M. and Clancy, D.M. and Zinoveva, A. and Mametnabiev, T. and Garabadzhiu, A.V. and Martin, S.J., Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation, FEBS Open Bio, 8, (5), 2018, p751-763
Martin S.J, A Guide to â~A Guide toâŠ.â articles, some thoughts on impact, and why you really should publish with The FEBS Journal, FEBS Journal, 285, (13), 2018, p2364 - 2366
Feltham, R. and Jamal, K. and Tenev, T. and Liccardi, G. and Jaco, I. and Domingues, C.M. and Morris, O. and John, S.W. and Annibaldi, A. and Widya, M. and Kearney, C.J. and Clancy, D. and Elliott, P.R. and Glatter, T. and Qiao, Q. and Thompson, A.J. and Nesvizhskii, A. and Schmidt, A. and Komander, D. and Wu, H. and Martin, S. and Meier, P., Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential, Cell Reports, 23, (2), 2018, p470-484
Sullivan G.P, Henry C.M, Clancy D.M, Mametnabiev T, Belotcerkovskaya E, Davidovich P, Sura-Trueba S, Garabadzhiu A.V, Martin S.J, Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases, Cell Death and Disease, 9, (3), 2018
Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin S.J, Steinberg F, Strisovsky K, Adrain C, ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE, eLife, 7, 2018
Clancy, D.M. and Sullivan, G.P. and Moran, H.B.T. and Henry, C.M. and Reeves, E.P. and McElvaney, N.G. and Lavelle, E.C. and Martin, S.J., Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing, Cell Reports, 22, (11), 2018, p2809-2817
Martin, S.J., The FEBS Journal in 2018 â" putting a bit of color in your life, and your figures, FEBS Journal, 285, (1), 2018, p4-7
Galluzzi, L. and Vitale, I. and Aaronson, S.A. and Abrams, J.M. and Adam, D. and Agostinis, P. and Alnemri, E.S. and Altucci, L. and Amelio, I. and Andrews, D.W. and Annicchiarico-Petruzzelli, M. and Antonov, A.V. and Arama, E. and Baehrecke, E.H. and Barlev, N.A. and Bazan, N.G. and Bernassola, F. and Bertrand, M.J.M. and Bianchi, K. and Blagosklonny, M.V. and Blomgren, K. and Borner, C. and Boya, P. and Brenner, C. and Campanella, M. and Candi, E. and Carmona-Gutierrez, D. and Cecconi, F. and Chan, F.K.-M. and Chandel, N.S. and Cheng, E.H. and Chipuk, J.E. and Cidlowski, J.A. and Ciechanover, A. and Cohen, G.M. and Conrad, M. and Cubillos-Ruiz, J.R. and Czabotar, P.E. and Dâ Angiolella, V. and Dawson, T.M. and Dawson, V.L. and de Laurenzi, V. and de Maria, R. and Debatin, K.-M. and DeBerardinis, R.J. and Deshmukh, M. and Di Daniele, N. and Di Virgilio, F. and Dixit, V.M. and Dixon, S.J. and Duckett, C.S. and Dynlacht, B.D. and El-Deiry, W.S. and Elrod, J.W. and Fimia, G.M. and Fulda, S. and GarcÃa-Sáez, A.J. and Garg, A.D. and Garrido, C. and Gavathiotis, E. and Golstein, P. and Gottlieb, E. and Green, D.R. and Greene, L.A. and Gronemeyer, H. and Gross, A. and Hajnoczky, G. and Hardwick, J.M. and Harris, I.S. and Hengartner, M.O. and Hetz, C. and Ichijo, H. and JÀÀttelÀ, M. and Joseph, B. and Jost, P.J. and Juin, P.P. and Kaiser, W.J. and Karin, M. and Kaufmann, T. and Kepp, O. and Kimchi, A. and Kitsis, R.N. and Klionsky, D.J. and Knight, R.A. and Kumar, S. and Lee, S.W. and Lemasters, J.J. and Levine, B. and Linkermann, A. and Lipton, S.A. and Lockshin, R.A. and López-OtÃn, C. and Lowe, S.W. and Luedde, T. and Lugli, E. and MacFarlane, M. and Madeo, F. and Malewicz, M. and Malorni, W. and Manic, G. and Marine, J.-C. and Martin, S.J. and Martinou, J.-C. and Medema, J.P. and Mehlen, P. and Meier, P. and Melino, S. and Miao, E.A. and Molkentin, J.D. and Moll, U.M. and Muñoz-Pinedo, C. and Nagata, S. and Nuñez, G. and Oberst, A. and Oren, M. and Overholtzer, M. and Pagano, M. and Panaretakis, T. and Pasparakis, M. and Penninger, J.M. and Pereira, D.M. and Pervaiz, S. and Peter, M.E. and Piacentini, M. and Pinton, P. and Prehn, J.H.M. and Puthalakath, H. and Rabinovich, G.A. and Rehm, M. and Rizzuto, R. and Rodrigues, C.M.P. and Rubinsztein, D.C. and Rudel, T. and Ryan, K.M. and Sayan, E. and Scorrano, L. and Shao, F. and Shi, Y. and Silke, J. and Simon, H.-U. and Sistigu, A. and Stockwell, B.R. and Strasser, A. and Szabadkai, G. and Tait, S.W.G. and Tang, D. and Tavernarakis, N. and Thorburn, A. and Tsujimoto, Y. and Turk, B. and Vanden Berghe, T. and Vandenabeele, P. and Vander Heiden, M.G. and Villunger, A. and Virgin, H.W. and Vousden, K.H. and Vucic, D. and Wagner, E.F. and Walczak, H. and Wallach, D. and Wang, Y. and Wells, J.A. and Wood, W. and Yuan, J. and Zakeri, Z. and Zhivotovsky, B. and Zitvogel, L. and Melino, G. and Kroemer, G., Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death and Differentiation, 2018, p1-56
Ioanna Oikonomidi and Emma Burbridge and Miguel Cavadas and Graeme Sullivan and Danielle Clancy and Blanka Collis and Jana Brezinova and Jana Humpolickova and Tianyi Hu and Andrea Bileck and Christopher Gerner and Alfonso Bolado and Alex von Kriegsheim and Kvido Strisovsky and Seamus J Martin and Colin Adrain, iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE, eLIFE, 2018
Chenette, E.J. and Martin, S.J., 50Â years of The FEBS Journal: looking back as well as ahead, FEBS Journal, 284, (24), 2017, p4162-4171
Gemayel, R. and Martin, S.J., Writing a successful fellowship or grant application, FEBS Journal, 284, (22), 2017, p3771-3777
Clancy, D.M. and Henry, C.M. and Sullivan, G.P. and Martin, S.J., Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines, FEBS Journal, 284, (11), 2017, p1712-1725
Henry, C.M. and Martin, S.J., Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory â FADDosomeâ Complex upon TRAIL Stimulation, Molecular Cell, 65, (4), 2017, p715-729.e5
Iurlaro, R. and PÃ"schel, F. and León-Annicchiarico, C.L. and O'Connor, H. and Martin, S.J. and Palou-Gramón, D. and Lucendo, E. and Muñoz-Pinedo, C., Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors, Molecular and Cellular Biology, 37, (10), 2017, e00479-16
Martin, S.J., The FEBS Journal in 2017: quality is its own reward, FEBS Journal, 284, (1), 2017, p4-6
Tiago Clemente, Narcisio J Vieira, Juan P Cerliani, Colin Adrain, Alexander Luthi, Mariana R Dominguez, Monica Yon, Fernanda C Barrence, Thalita B Riul, Richard D Cummings, Telma M Zorn, Sebastian Amigorena, Marcelo Dias-Baruffi, Maurício M Rodrigues, Seamus J Martin, Gabriel A Rabinovich, Gustavo P Amarante-Mendes, Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery, Cell Death and Disease, 8, (12), 2017, pe3176
Kearney, C.J. and Martin, S.J., An Inflammatory Perspective on Necroptosis, Molecular Cell, 65, (6), 2017, p965-973
Clancy D.M, Martin S.J, Getting a gRIP on Flu by Casting the DAI, Cell Host and Microbe, 20, (5), 2016, p552 - 554
Chenette, E.J. and Martin, S.J., Words of Advice: for what it's worth, our tuppenceworth, FEBS Journal, 283, (21), 2016, p3856
Chipuk J.E, Martin S.J, Special Issue on Cell Death: Murder, mystery (and a little bit of mayhem) in Manhattan, FEBS Journal, 2016, p2565 - 2567
Clancy D.M, Henry C.M, Davidovich P.B, Sullivan G.P, Belotcerkovskaya E, Martin S.J, Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs, FEBS Open Bio, 6, (4), 2016, p338 - 348
Martin S.J, Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system, FEBS Journal, 2016, p2599 - 2615
Seamus J. Martin, The FEBS Journalin 2016: read, reflect and don't feed the wolves, FEBS Journal, 283, (1), 2016, p4--8
Henry C.M, Sullivan G.P, Clancy D.M, Afonina I.S, Kulms D, Martin S.J, Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines, Cell Reports, 14, (4), 2016, p708 - 722
Cullen S.P, Kearney C.J, Clancy D.M, Martin S.J, Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis, Cell Reports, 11, (10), 2015, p1535 - 1548
Kearney CJ, Cullen SP, Tynan GA, Henry CM, Clancy D, Lavelle EC, Martin SJ, Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production., Cell death and differentiation, 22, 2015, p1313-1327
Galluzzi L, Pietrocola F, Bravo-San Pedro J.M, Amaravadi R.K, Baehrecke E.H, Cecconi F, Codogno P, Debnath J, Gewirtz D.A, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri M.C, Martin S.J, Penninger J, Piacentini M, Rubinsztein D.C, Simon H.-U, Simonsen A, Thorburn A.M, Velasco G, Ryan K.M, Kroemer G, Autophagy in malignant transformation and cancer progression, EMBO Journal, 34, (7), 2015, p856 - 880
Cullen SP, Martin SJ., Fas and TRAIL 'death receptors' as initiators of inflammation: Implications for cancer., Semin Cell Dev Biol., 39, 2015, p26-34
Seamus J. Martin, John Hardy is the UK's first Breakthrough Prize laureate, FEBS Journal, 282, (24), 2015, p4641--4642
Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP, A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence., Genes & Development, 29, (21), 2015, p2231-43
Afonina I.S, Müller C, Martin S.J, Beyaert R, Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme, Immunity, 42, (6), 2015, p991 - 1004
Martin S, Dudek-Peri- A.M, Maes H, Garg A.D, Gabrysiak M, Demirsoy S, Swinnen J.V, Agostinis P, Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells, Biochemical Pharmacology, 93, (3), 2015, p290 - 304
Martin S.J, The FEBS Journal in 2015: Onwards and upwards, FEBS Journal, 282, (1), 2015, p1 - 3
Kearney, C.J., Cullen,. S.P., Clancy, D., Martin, S. J., RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis, FEBS Journal, 281, (21), 2014, p4921-4934
Martin,Seamus J. S.J., The FEBS Journal: Passing the editorial baton, FEBS Journal, 281, (1), 2014, p1-2
C Muñoz-Pinedo and S J Martin, Autosis: A new addition to the cell death tower of babel, Cell Death and Disease, 5, (7), 2014, pe1319-
Davidovich, P., Kearney, C.J., Martin, S.J., Inflammatory outcomes of apoptosis, necrosis and necroptosis, Biological Chemistry, 395, (10), 2014, p1163-1171
Hollville,Ã milie E., Carroll,Richard G. R.G., Cullen,Sean P. S.P., Martin,Seamus J. S.J., Bcl-2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1-dependent mitophagy, Molecular Cell, 55, (3), 2014, p451-466
Galluzzi,Lorenzo L., Bravo-San Pedro,José Manuel Bravo San J.M.B.S., Vitale,Ilio I., Aaronson,S. A. S.A., Abrams,J. M. J.M., Adam,D. D., Alnemri,Emad S. E.S., Altucci,L. L., Andrews,David William A D.W.A., Annicchiarico-Petruzzelli,M. M., Baehrecke,Eric H. E.H., Bazán,Nicolás G. N.G., Bertrand,M. J. M.J., Bianchi,K. K., Blagosklonny,Mikhail V. M.V., Blomgren,K. K., Borner,Christoph M B C.M.B., Bredesen,Dale E. D.E., Brenner,C. C., Campanella,M. M., Candi,Eleonora E., Cecconi,F. F., Chan,F. K. F.K., Chandel,N. S. N.S., Cheng,E. H. E.H., Chipuk,Jerry E Edward J.E., Cidlowski,John Anthony J.A., Ciechanover,Aaron J. A.J., Dawson,T. M. T.M., Dawson,V. L. V.L., De Laurenzi,Vincenzo V., De Maria,Ruggero R., Debatin,K. M. K.M., Di Daniele,Nicola Di N.D., Dixit,V. M. V.M., Dynlacht,Brian David B.D., El-Deiry,Wafik S. W.S., Fimia,Gian MarÃa G.M., Flavell,R. A. R.A., Fulda,Simone S., Garrido,C. C., Gougeon,Marie Lise M.L., Green,Douglas R. D.R., Gronemeyer,Hinrich J. H.J., Hajnóczky,György G., Hardwick,J. M. J.M., Hengartner,Michael Otmar M.O., Ichijo,H. H., Joseph,B. B., Jost,P. J. P.J., Kaufmann,T. T., Kepp,Oliver O., Klionsky,Daniel J. D.J., Knight,Richard Austen R.A., Kumar,Sharad S., Lemasters,John J. J.J., Levine,B. B., Linkermann,Andreas A., Lipton,S. A. S.A., Lockshin,R. A. R.A., López-OtÃn,Carlos C., Lugli,Enrico E., Madeo,Frank F. F.F., Malorni,Walter W., Marine,Jean Christophe W J.C.W., Martin,Seamus J. S.J., Martinou,J. C. J.C., Medema,Jan Paul J.P., Meier,P. P., Melino,S. S., Mizushima,N. N., Möll,Ute M. U.M., Muñoz-Pinedo,Cristina C., Nuñez,G. G., Oberst,A. A., Panaretakis,Theocharis T., Penninger,Josef Martin J.M., Peter,M. E. M.E., Piacentini,Mauro M., Pinton,Paolo P., Prehn,Jochen H M J.H.M., Puthalakath,Hamsa H., Rabinovich,Gabriel Adrián G.A., Ravichandran,K. S. K.S., Rizzuto,Rosario R. R.R., Rodrigues,C. M. C.M., Rubinsztein,David C. D.C., Rudel,T. T., Shi,Y. Y., Simon,H. U. H.U., Stockwell,B. R. B.R., Szabadkai,György G., Tait,S. W. S.W., Tang,H. L. H.L., Tavernarakis,Nektarios N., Tsujimoto,Y. Y., Vanden Berghe,Tom T., Vandenabeele,Peter P., Villunger,A. A., Wagner,E. F. E.F., Walczak,H. H., White,E. E., Wood,W. G. W.G., Yuan,J. J., Zakeri,Z. Z., Zhivotovsky,Boris D. B.D., Melino,Gerry G., Kroemer,Guido G., Essential versus accessory aspects of cell death: recommendations of the NCCD 2015, Cell Death and Differentiation, 2014
Carroll,Richard G. R.G., Hollville,Ã milie E., Martin,Seamus S., Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1, Cell Reports, 9, (4), 2014, p1538-1553
Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ, Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells., Molecular cell, 49, 2013, p1-15
Henry,Conor M. C.M., Hollville,Ã milie E., Martin,Seamus J. S.J., Measuring apoptosis by microscopy and flow cytometry, Methods, 61, (2), 2013, p90-97
Kearney CJ, Sheridan C, Cullen SP, Tynan GA, Logue SE, Afonina IS, Vucic D, Lavelle EC, Martin SJ, Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production., The Journal of biological chemistry, 288, (7), 2013, p4878-4890
Martin,Seamus J. S.J., Henry,Conor M. C.M., Distinguishing between apoptosis, necrosis, necroptosis and other cell death modalities, Methods, 61, (2), 2013, p87-89
Carroll RG, Martin SJ, Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You., Cancer cell, 23, (4), 2013, p425-426
Kearney,Conor J. C.J., Martin,Seamus J. S.J., Competition for growth factors: A lot more death with a little less Aktion, Cell Death and Differentiation, 20, (10), 2013, p1291-1292
Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., (...), Zuckerbraun, B., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, (4), 2012, p445-544
Martin SJ, Henry CM, Cullen SP, A perspective on mammalian caspases as positive and negative regulators of inflammation., Molecular cell, 46, (4), 2012, p387-397
Martin, S.J., Henry, C.M., Cullen, S.P., A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation, Molecular Cell, 46, (4), 2012, p387-397
Hollville, E., Martin, S.J., Greasing the path to BAX/BAK activation, Cell, 148, (5), 2012, p845-846
Walsh JG, Logue SE, Luthi AU, Martin SJ, Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme., The Journal of Biological Chemistry, 286, (37), 2011, p32513-32524
Cullen SP, Henry CM, Martin SJ, Staying alive: defensive strategies in the BCL-2 family playbook., Molecular cell, 44, (4), 2011, p509-10
Afonina, I.S., Tynan, G.A., Logue, S. E., Cullen, S.P., Bots, M., Lüthi, A.U., Reeves, E.P., McElvaney, N.G., Medema, J.P., Lavelle, E.C. and Martin, S.J., Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1, Molecular Cell, 44, (2), 2011, p465 - 478
Elgendy, M, Sheridan, C, Brumatti, G, Martin, SJ, Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival, Molecular Cell, 42, (1), 2011, p23-35
Martin, S.J., Oncogene-induced autophagy and the Goldilocks principle, Autophagy, 7, (8), 2011, p922-923
Martin, S.J. , Mitochondrial fusion : Bax to the Fussure, Developmental Cell, 20, (2), 2011, p142-143
Martin, S.J., Opening the cellular poison cabinet., Science, 330, 2010, p1330-1331
Clare Sheridan and Seamus J. Martin, Mitochondrial fission/fusion dynamics and apoptosis, Mitochondrion, 10, (6), 2010, p640-648
Sheridan, C., Brumatti G., Elgendy, M., Brunet, M. and S. J. Martin., An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs., Oncogene, 29, 2010, p6428-6441
von Kampen O, Lipinski S, Till A, Martin S.J., Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P., The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling, The Journal of Biological Chemistry, 285, 2010, p19921-19926
Sheridan, C, Brumatti, G, Elgendy, M, Brunet, M, Martin, SJ, An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs, Oncogene, 29, (49), 2010, p6428-6441
Afonina, I., Cullen S. P and S. J. Martin., Cytotoxic and non cytotoxic roles of the CTL/NK proteases granzyme B. , Immunological Reviews, 235, (1), 2010, p105-116
Autret A, Martin SJ, Bcl-2 family proteins and mitochondrial fission/fusion dynamics., Cellular and molecular life sciences : CMLS, 67, (10), 2010, p1599-1606
Cullen SP, Brunet M, Martin SJ, Granzymes in cancer and immunity., Cell death and differentiation, 2010, p616-623
Carney, K., Latkowski, S., Maldonado-Basilio, R., Landais, P., Lennox, R., Bradley, A.L., Characterization of a multi-electrode bulk-SOA for low NF in-line amplification in passive optical networks, Prodeedings of 12th International Conference on Transparent Optical Network, 12th International Conference on Transparent Optical Networks, ICTON , Munich; Germany, 27 Jun - 1 Jul, 2010, ppart. no. 5549103
Von Kampen, O., Lipinski, S., Till, A., Martin, S.J., Nietfeld, W., Lehrach, H., Schreiber, S., Rosenstiel, P., Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling, Journal of Biological Chemistry, 285, (26), 2010, p19921-19926
Autret A, Martin SJ, Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis., Molecular cell, 36, (3), 2009, p355-63
Adrain C, Martin SJ, Apoptosis: calling time on apoptosome activity., Science signaling, 2, (91), 2009, ppe62
Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, and Seamus J. Martin, Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases, Immunity, 31, (1), 2009, p84-98
Logue SE, Elgendy M, Martin SJ, Expression, purification and use of recombinant annexin V for the detection of apoptotic cells., Nature protocols, 4, (9), 2009, p1383-95
SP Cullen, SJ Martin, Caspase activation pathways: some recent progress, Cell Death and Differentiation, 16, (7), 2009, p935 - 938
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G, Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes., Cell death and differentiation, 16, (8), 2009, p1093-1107
Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ, Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival., PloS one, 4, (3), 2009, pe5055
Cullen SP, Afonina IS, Donadini R, Lüthi AU, Medema JP, Bird PI, Martin SJ, Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing., The Journal of biological chemistry, 284, (8), 2009, p5137-5147
Logue SE, Martin SJ., Caspase activation cascades in apoptosis., Biochem Soc Trans. , 36 , (1), 2008, p1-9.
Sheridan C, Martin SJ, Commitment in apoptosis: slightly dead but mostly alive., Trends in cell biology, 18, (8), 2008, p353-357
Sheridan C, Delivani P, Cullen SP, Martin SJ, Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release., Molecular Cell, 31, (4), 2008, p570-85
Cullen SP, Lüthi AU, Martin SJ, Analysis of apoptosis in cell-free systems., Methods (San Diego, Calif.), 44, (3), 2008, p273-279
Martin SJ., Improvement by death in immunity., Cell Death Differ., 15, (2), 2008, p221-2
Sheridan C, Brumatti G, Martin SJ, Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim., The Journal of biological chemistry, 283, (32), 2008, p22128-35
Adrain, C., Martin, S.J., Caspases: Agents of Defense and Destruction, Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts, 1, 2008, p259-281
Lüthi, A.U., Cullen, S.P., Martin, S.J., Chapter Seventeen Two-Dimensional Gel-Based Analysis of the Demolition Phase of Apoptosis, Methods in Enzymology , 442, 2008, p343-354
Taylor RC, Cullen SP, Martin SJ., Apoptosis: controlled demolition at the cellular level., Nature Reviews in Molecular Cell Biology, 9, (3), 2008, p231 - 241
Walsh JG, Cullen SP, Sheridan C, Lüthi AU, Gerner C, Martin SJ, Executioner caspase-3 and caspase-7 are functionally distinct proteases., Proceedings of the National Academy of Sciences of the United States of America, 105, (35), 2008, p12815-12819
Martin SJ., Getting the measure of apoptosis., Methods, 44, (3), 2008, p197-9
Cullen SP, Martin SJ, Mechanisms of granule-dependent killing., Cell death and differentiation, 15, (2), 2008, p251-62
Lüthi AU, Cullen SP, Martin SJ, Two-dimensional gel-based analysis of the demolition phase of apoptosis., Methods in enzymology, 442, 2008, p343-54
Brumatti G, Sheridan C, Martin SJ., Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells., Methods., 44, (3), 2008, p235-40
Cullen SP, Adrain C, Lüthi AU, Duriez PJ, Martin SJ, Human and murine granzyme B exhibit divergent substrate preferences., The Journal of Cell Biology, 176, (4), 2007, p435 - 444
Lüthi AU, Martin SJ., The CASBAH: a searchable database of caspase substrates., Cell Death and Differentiation, 14, (4), 2007, p641 - 650
Taylor RC, Brumatti G, Ito S, Hengartner MO, Derry WB, Martin SJ., Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease., J. Biol. Chem., 282, (20), 2007, p15011 - 15021
Adrain, C. and S. J. Martin , Double knockout blow for caspases. , Science, 311, 2006, p785 - 786
Adrain, C., Duriez, P. J., Brumatti, G., Delivani, P., and S. J. Martin , The cytotoxic lymphocyte protease, Granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics., J. Biol. Chem, 281, (12), 2006, p8118 - 8125
Adrain, C., Brumatti, G. and S. J, Martin, Apoptosomes: caspase activation platforms to die from., TRENDS IN BIOCHEMICAL SCIENCES, 31, (5), 2006, p243 - 247
Delivani P, Martin SJ., Mitochondrial membrane remodeling in apoptosis: an inside story., Cell Death Differ. , 13, (12), 2006, p2007-10
Delivani, P., Adrain, C., Taylor, RC., Duriez, P.J & S. J. Martin , Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics., MOLECULAR CELL, 21, (6), 2006, p761 - 773
Peter J. Delves, Seamus J. Martin, Dennis Burton & Ivan M. Roitt, ESSENTIAL IMMUNOLOGY, 11th Edition, UK, Blackwell Scientific, 2006
Adrain, C., Murphy, B.M., Martin, S.J., Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B, Journal of Biological Chemistry, 280, (6), 2005, p4663-4673
Kroemer G, Martin SJ., Caspase-independent cell death., NATURE MEDICINE, 11, (7), 2005, p725 - 730
Adrain, C., Murphy, B. M., and S. J. Martin , Molecular Ordering of the Caspase Activation cascade Initiated by the CTL/NK Protease Granzyme B., J. Biol. Chem, 280, (6), 2005, p4663 - 4673
Taylor RC, Adrain C, Martin SJ, Proteases, proteasomes and apoptosis: breaking Ub is hard to do., CELL DEATH & DIFFERENTIATION, 12, (9), 2005, p1213 - 1217
Brunner T, Martin SJ, c-Myc - Where death and division collide, CELL CYCLE, 3, (4), 2004, p456 - 459
Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ, Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (26), 2004, p26906 - 26914
Martin SJ, An Apollon vista of death and destruction, NATURE CELL BIOLOGY, 6, (9), 2004, p804 - 806
Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K, Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex , J. Biol. Chem, 279, (19), 2004, p19665 - 19682
Murphy BM, Creagh EM, Martin SJ, Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36916 - 36922
Munarriz, E., Barcaroli, D., Stephanou, A., Townsend, P.A., Maisse, C., Terrinoni, A., Neale, M., Martin, S. J., Latchman, D. S., Knight, R.A., Melino, G. and De Laurenzi, V. , PIAS-1 Is a Check Point Regulator Which Affects Exit from G1 and G2 by Sumoylation of p73., Molecular and Cellular Biology, 24, (24), 2004, p10593 - 10610
Yang J.Y., Michod D., Walicki J., Murphy B.M., Kasibhatla S., Martin S. J., and Widmann C. , Partial Cleavage of RasGAP by Caspases Is Required for Cell Survival in Mild Stress Conditions., Molecular and Cellular Biology, 24, (23), 2004, p10425 - 10436
Adrain C, Creagh EM, Cullen SP, Martin SJ, Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36923 - 36930
Munarriz, E., Barcaroli, D., Stephanou, A., Townsend, P.A., Maisse, C., Terrinoni, A., Neale, M.H., Martin, S.J., Latchman, D.S., Knight, R.A., Melino, G., De Laurenzi, V., PIAS-1 is a checkpoint regulator which affects exit from G
Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ, Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes, EMBO JOURNAL, 23, (10), 2004, p2134 - 2145
Adrain C, Creagh EM, Martin SJ, Defying death: showing Bcl-2 the way home, NATURE CELL BIOLOGY, 5, (1), 2003, p9 - 11
Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SK, Iodine-124 labelled Annexin-V as a potential radiotracer to study apoptosis using positron emission tomography, APPLIED RADIATION AND ISOTOPES, 58, (1), 2003, p55 - 62
Creagh, E. M. and S. J. Martin., Cell stress-associated caspase activation: Intrinsically complex? , SCIENCE Stke, 175, 2003, p1 - 11
Murphy, B.M., O'Neill, A.J., Adrain, C., Watson, R.W.G., Martin, S.J., The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome c, Journal of Experimental Medicine, 197, (5), 2003, p625-632
Murphy, B. M., O'Neill, A. J., Adrain, C., Watson, R. W. G. and S. J. Martin , The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c., THE JOURNAL OF EXPERIMENTAL MEDICINE, 197, 2003, p625 - 632
Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EO, In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope , BRITISH JOURNAL OF CANCER, 89, (7), 2003, p1327 - 1333
Brona M. Murphy, Seamus J. Martin, Caspases, Essentials of Apoptosis, 2003, p3--12
Hill MM, Adrain C, Martin SJ., Portrait of a killer: the mitochondrial apoptosome emerges from the shadows., Molecular Interventions , 3, 2003, p19 - 26
Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity., Immunological reviews, 193, 2003, p10-21
Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity, IMMUNOLOGICAL REVIEWS, 193, (1), 2003, p10 - 21
Bouchier-Hayes, L & Martin SJ, CARD games in apoptosis and immunity, EMBO REPORTS, 3, (7), 2002, p616-621
van Loo G, Saelens X, van Gurp M, MacFarlane M, Martin SJ, Vandenabeele P, The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet., CELL DEATH AND DIFFERENTIATION, 9, 2002
Martin, SJ, Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. , CELL, 109, 2002
Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., The Journal of biological chemistry, 276, (47), 2001, p44069-77
Creagh EM, Martin SJ, Caspases: cellular demolition experts., BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p696 - 702
Adrain, C & Martin, SJ, The mitochondrial apoptosome: a killer unleashed by the cytochrome seas, TRENDS IN BIOCHEMICAL SCIENCES, 26, 2001
Martin, S.J., Dealing the CARDs between life and death, Trends in Cell Biology, 11, (5), 2001, p188-189
Adrain C, Martin SJ, Search for Drosophila caspases bears fruit: STRICA enters the fray, CELL DEATH & DIFFERENTIATION, 8, (4), 2001, p319 - 323
Slee EA, Adrain C, Martin SJ, Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis., Journal of Biological Chemistry, 276, 2001, p7320 - 7326
Adrain C, Creagh EM, Martin SJ, Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2, THE EMBO JOURNAL, 20, 2001, p6627 - 6636
Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ., CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 2001, p44069 - 44077
Eléouët, J.-F., Slee, E.A., Saurini, F., Castagné, N., Poncet, D., Garrido, C., Solary, E., Martin, S.J., The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis, Journal of Virology, 74, (9), 2000, p3975-3983
Slee, E.A., Keogh, S. A., and Martin, S. J, Cleavage of BID During Cytotoxic Drug and UV Radiation-Induced Apoptosis Occurs Downstream of the Point of Bcl-2 Action and is Catalysed by Caspase-3: a Potential Feedback Loop for Amplification of Apoptosis-Associated Mitochondrial Cytochrome c Release, Cell Death & Differentiation, 7, 2000, p556 - 565
Eleouet, J.-F., Slee, E. A., Saurini, F., Castagné, N., Poncet, D., Garrido, C., Solary, E. and Martin, S. J, The viral nucleoprotein of the transmissible gastroenteritis coronavirus, TGEV, is cleaved by caspases -6 and -7 during TGEV-induced apoptosis: a potential host-defense mechanism for limiting virus replication during infection, The Journal of Virology , 74, 2000, p3975 - 3983
Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ, Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis, FEBS LETTERS, 471, 2000, p93 - 98
Slee, E.A., Harte, M.T., Kluck, R.M., Wolf, B.B., Casiano, C.A., Newmeyer, D.D., Wang, H.-G., Reed, J.C., Nicholson, D.W., Alnemri, E.S., Green D.R., and Martin S.J, Ordering the Cytochrome c-Initiated Caspase Cascade: Hierarchical Activation of Caspases -2, -3, -6, -7, -8 and -10 in a Caspase-9-Dependent Manner, THE JOURNAL OF CELL BIOLOGY, 144, 1999, p281 - 292
Adrain, C., Slee, E.A., Harte, M. T., and Martin S. J, Regulation of Apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region, The Journal of Biological Chemistry , 274, 1999, p20855 - 20860
Slee, E.A., Adrain, C. and Martin, S.J, Serial killers: Ordering caspase activation events in apoptosis, Cell Death and Differentiation, 6, 1999, p1067 - 1074
Slee, E.A., Adrain, C. and Martin, S.J, Serial killers: Ordering caspase activation events in apoptosis, Cell Death and Differentiation, 6, 1999, p1067 - 1074
Slee, E.A. and Martin, S.J, Regulation of caspase activation in apoptosis; implications for transformation and drug resistance, Cytotechnology, 27, 1999, p309 - 320
Martin, S. J, Apoptosis, In The Encyclopedia of Immunology 2nd edition, 1998, p220 - 227
Slee, E.A., Harte, M.T., and Martin, S.J, A duel to the death: activated caspases meet their substrates, Sepsis , 2, 1998, p21 - 29
Slee, E.A., Harte, M.T., Martin, S.J., A Duel to the Death: Activated Caspases Meet Their Substrates, Sepsis, 2, (1), 1998, p21-29
Van Antwerp DJ, Martin SJ, Verma IM, Green DR, Inhibition of TNF-induced apoptosis by NF-kappa B, Trends in Cell Biology , 8, 1998, p107 - 111
Amarante-Mendes, GP, Finucane, DM, Martin, SJ, Cotter, TG, Salvesen, GS, Green, DR, Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death., Cell Death and Differentiation , 5, 1998, p298 - 306
Apoptosis in, editor(s)I. M. Roitt and P. J. Delves , In The Encyclopedia of Immunology 2nd edition, London, UK, Academic Press, 1998, pp220 - 227, [S. J Martin]
Kluck, R.M., Martin, S. J., Hoffman, B.M., Zhou, J.S., Green, D.R., and Newmeyer, D.D, cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. , EMBO Journal , 16, 1997, p4639 - 4649
Morphological features of apoptosis in, L.A. Herzenberg, D. M. Weir, L. Herzenberg, and C. Blackwell , In Weir's Handbook of Experimental Immunology 5th Edition , Blackwell Science, S. J Martin and Green, D. R, 1997, [S. J Martin ]
Di Stefano, L., Boland, F., A new phase extraction algorithm for phase profilometry, Machine Vision and Applications, 10, (4), 1997, p188-200.
Kluck, R.M., Martin, S.J., Hoffman, B.M., Zhou, J.S., Green, D.R., Newmeyer, D.D., Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system, EMBO Journal, 16, (15), 1997, p4639-4649
Tan, X., Martin, S. J., Green, D. R., and Wang, Jean Y. J, Degradation of retinoblastoma protein in TNF- and CD95-induced cell death, The Journal of Biological Chemistry , 272, 1997, p9613 - 9616
McGahon, A. J., Brown, D., Martin, S. J., Amarante-Mendes, G., Cotter, T. G., Cohen, G. M., and D. R., Green, Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death, Cell Death and Differentiation , 4, 1997, p95 - 104
Corbeil, J., and Martin, S. J, Apoptosis in HIV-1 induced pathogenesis, Trends in Experimental and Clinical Medicine, 7, 1997, p61 - 71
Tan, X., Martin, S.J., Green, D.R., Wang, J.Y.J., Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death, Journal of Biological Chemistry, 272, (15), 1997, p9613-9616
Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS,, Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases, The Journal of Neuroscience , 17, 1997, p6165 - 6178
Santana, P., Pena, L. A., Haimovitz-Friedman, A., Martin, S. J., Green, D. R., Cordon-Cardo, C., Schuchman, E. H., Fuks, Z., and Kolesnick, R, Acid sphingomyelinase-deficient mice and human lymphoblasts are defective in radiation-induced apoptosis, Cell, 86, 1996, p189 - 199
Green, D. R., and Martin, S. J, Cell Death and Differentiation The ICE/Ced-3 family proteases as the apoptot , Cell Death and Differentiation, 3, 1996, p339 - 340
Casiano, C.A., Martin, S.J., Green, D.R., Tan, E.M., Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)- mediated T cell apoptosis, Journal of Experimental Medicine, 184, (2), 1996, p765-770
Green, D.R., Martin, S.J., The ICE/Ced-3-family proteases as the apoptotic executioner, Cell Death and Differentiation, 3, (3), 1996, p339-340
Van Antwerp, D., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M, Suppression of TNF-a-induced apoptosis by NFkB, SCIENCE , 274, 1996, p787 - 789
Green, D. R., McGahon, A., and Martin S. J, Regulation of apoptosis by oncogenes , Journal of Cellular Biochemistry , 60, 1996, p33 - 38
Santana, P., Peña, L.A., Haimovitz-Friedman, A., Martin, S., Green, D., McLoughlin, M., Cordon-Cardo, C., Schuchman, E.H., Fuks, Z., Kolesnick, R., Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis, Cell, 86, (2), 1996, p189-199
Casiano, C. A., Martin, S. J., Green, D. R., and Tan E. M, The Journal of Experimental Medicine Proteolysis of a subset of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis, The Journal of Experimental Medicine, 184, 1996, p765 - 770
Green, D.R., Amarante-Mende, G., Martin, S., Scissors for the executioner: central mechanisms of apoptosis in cell mediated cytotoxicity, FASEB Journal, 10, (6), 1996
Meisenholder, G. W., Martin, S. J., Green, D. R., Nordberg, J., Babior, B. M., and Gottlieb, R. A, Events in apoptosis: acidification is downstream of protease activation and Bcl-2 protection, The Journal of Biological Chemistry , 271, 1996, p16260 - 16262
Martin, S. J., Finucane, D., Amarante-Mendes, G., O'Brien, G. A., and Green, D. R, Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. , The Journal of Biological Chemistry, 271, 1996, p28753 - 28756
Martin, S. J., Amarante-Mendes, G. P., Shi, L., Chuang, T.-H., Casiano, C. A., O'Brien, G. A., Fitzgerald, P., Tan, E. M., Bokoch, G. M., Greenberg, A. H., and Green, D. R., The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. , The EMBO Journal , 15, 1996, p2407 - 2416
Martin, S.J., Green, D.R., Apoptosis during HIV infection: A cytopathic effect of HIV or an important host-defense mechanism against viruses in general?, Advances in Experimental Medicine and Biology, 374, 1995, p129-138
Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S., Nishloka, W., Brunner, T., Baier, G., Baler-Bltterlich, G., Byrd, C., Lang, F., Kolesnick, R., Altman, A., Green, D., FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway, Immunity, 2, (4), 1995, p341-351
Martin, S. J., McGahon, A. J., Nishioka, W. K., La Face, D., Guo, X., Th'ng, J., Bradbury, E. M., and Green, D. R, p34cdc2 and apoptosis, Science, 269, 1995, p106 - 107
Martin, S. J. and D. R. Green , Critical Reviews in Oncology and Hematology , Apoptosis and Cancer: The failure of controls on cell death and cell survival, 18, 1995, p616 - 621
Brunner, T., Mogil, R.J., LaFace, D., Jin Yoo, N., Mahboubl, A., Echeverri, F., Martin, S.J., Force, W.R., Lynch, D.H., Ware, C.F., Green, D.R., Cell-autonomous fas (CD95)/fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas, Nature, 373, (6513), 1995, p441-444
Martin, S. J., Reutelingsperger, C. P. M., McGahon, A. J., Rader, J., van Schie, R. C. C. A., LaFace, D., and Green, D. R, Redistribution of plasma membrane phospholipids is an early and widespread event during apoptosis: inhibition by overexpression of Bcl-2 and Abl, THE JOURNAL OF EXPERIMENTAL MEDICINE, 182, 1995, p1545 - 1556
Green, D. R., and Martin, S, The killer and the executioner: how apoptosis controls malignancy, The Current Opinion in Immunology, 7, 1995, p694 - 703
Martin, S. J., and Green, D. R, ICE/CED-3 protease (caspase) activation during apoptosis: death by a thousand cuts, Cell, 82, 1995, p349 - 352
McGahon, A. J., Nishioka, W. K., Martin, S. J., Cotter, T. G., and Green, T. G, Inhibition of Fas-induced apoptosis by Abl, The Journal of Biological Chemistry, 270, 1995, p22625 - 22631
Martin, S.J., Green, D.R., Protease activation during apoptosis: Death by a thousand cuts?, Cell, 82, (3), 1995, p349-352
Martin, S. J., Takayama, S., McGahon, A. J., Corbeil, J., Kolesnick, R. N., Reed, J. C., and Green, D. R, Inhibition of ceramide-induced apoptosis by Bcl-2, Cell Death and Differentiation, 2, 1995, p253 - 257
Brunner, T., Mogil, R., Mahboubi, A., La Face, D., Yoo, N., Echeverri, F., Martin, S. J., Force, R.W., Lynch, D. H., Ware, C., and Green, D. , Cell autonomous Fas (CD95)/Fas-ligand interaction involved in apoptosis of activated T cells, NATURE, 373, 1995, p441 - 444
Martin, S. J., Newmeyer, D. D., Mathias, S., Farschon, D., Wang, H.-G., Reed, J. C., Kolesnick, R. N., and Green, D. R, Cell-free reconstitution of Fas - UV radiation- and ceramide-induced apoptosis., The EMBO Journal, 14, 1995, p5191 - 5200
Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S. J., Brunner, T., Nishioka, W., Baier, G., Bitterlich-Baier, G., Byrd, C., Lang, F., Koelsnick, R., Altman, A., and Green, D. R, Fas-induced apoptosis is mediated by a ceramide-initiated Ras signalling pathway, IMMUNITY, 2, 1995, p341 - 351
Martin, S. J., O'Brien, G. A., McGahon, A. J., Nishioka, W. K., Saido, T., and Green, D, Proteolysis of fodrin (nonerythroid spectrin) during apoptosis, The Journal of Biological Chemistry...., 270, 1995, p6425 - 6428
McGahon, A.J., Nishioka, W.K., Martin, S.J., Mahboubi, A., Cotter, T.G., Green, D.R., Regulation of the Fas apoptotic cell death pathway by Abl, Journal of Biological Chemistry, 270, (38), 1995, p22625-22631
Vyakarnam, A., Matear, P., and S. J. Martin and Wagstaff, M, Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells, Immunology, 86, 1995, p85 - 96
Martin, S.J., Reutelingsperger, C.P.M., McGahon, A.J., Rader, J.A., Van Schie, R.C.A.A., LaFace, D.M., Green, D.R., Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl, Journal of Experimental Medicine, 182, (5), 1995, p1545-1556
McGahon, A. J., Martin, S. J., Bissonnette, R. P., Mahboubi, A., Shi, Y., Mogil, R. J., Nishioka, W. K., and D. R. Green , The end of the (cell) line: Methods for the study of apoptosis in vitro , Methods in Cell Biology, 46, 1995, p153 - 185
Martin, S.J., Green, D.R., Apoptosis and cancer: the failure of controls on cell death and cell survival, Critical Reviews in Oncology and Hematology, 18, (2), 1995, p137-153
Martin, S. J., Matear, P. M. and A. Vyakarnam, HIV-1 infection of human CD4+ T cells in vitro: Differential induction of apoptosis in these cells, Journal of Immunology , 152, 1994, p330 - 342
Martin , S. J., and Green, D. R, Apoptosis as a goal of cancer therapy, Current Opinion in Oncology, 6, 1994, p616 - 621
Martin S. J., Green, D. R., and T. G. Cotter , Dicing with death: dissecting the components of the apoptosis machinery, Trends in Biochemical Sciences, 19, 1994, p26 - 30
Martin, S. J., Vyakarnam, A., Cheingsong-Popov, R., Callow, D., Senior, J., Jones, K., Adams, S., Kingsman, A., Gotch, F., McMichael, A., Roitt, I. M., and J. N. Weber , Human HIV-seronegative volunteers immunized with recombinant p17/p24:Ty-virus like particles (p17/p24:Ty-VLP) develop p24-specific cellular and humoral immune responses, AIDS, 7, 1993, p1315 - 1323
Martin, S. J. , Programmed cell death and AIDS, SCIENCE, 262, 1993, p1355 - 1356
Martin, S.J., Vyakarnam, A., Cheingsong-Popov, R., Callow, D., Jones, K.L., Senior, J.M., Adams, S.E., Kingsman, A.J., Matear, P., Gotch, F.M., McMichael, A.J., Roitt, I.M., Weber, J.N., Immunization of human HIV-seronegative volunteers with recombinant p17/p24:Ty virus-like particles elicits HIV-1 p24-specific cellular and humoral immune responses, AIDS, 7, (10), 1993, p1315-1323
Martin, S. J, Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts, Immunology Letters, 35, 1993, p125 - 134
Martin, S.J., Apoptosis: suicide, execution or murder?, Trends in Cell Biology, 3, (5), 1993, p141-144
Martin, S. J, Apoptosis: Suicide, Execution or Murder? Conflicting evidence for protein and RNA synthesis requirements for apoptosis , Trends in Cell Biology, 3, 1993, p141 - 144
Weber, J., Kennedy, A., Callow, D., Zigmond, A., Popov, R.C., Martin, S., Vyakarnam, A., Gutch, F., McMichael, A., Adams, S., Kingsman, A., A Phase I clinical study of the safety, toxicity, and immunogenicity of the Ty,p24,VLP in healthy volunteers - Interim report, AIDS Research and Human Retroviruses, 8, (8), 1992
MARTIN, S.J., MAZDAI, G., STRAIN, J.J., COTTER, T.G., HANNIGAN, B.M., Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency, Clinical & Experimental Immunology, 83, (2), 1991, p338-343
Martin, S. J. and T. G. Cotter , Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis, International Journal of Radiation Biology , 59, 1991, p1001 - 1016
Martin, S. J., Madzai, G., Strain, J. J., Cotter, T. G. and B. M. Hannigan, Clinical and Experimental.Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency, Immunology, 83, 1991, p338 - 343
Lennon, S. V., Martin, S. J. and T. G. Cotter , apoptosis in human tumour cell lines by widely diverging stimuli , Cell Proliferation, 24, 1991, p203 - 214
Lennon, S.V., Martin, S.J., Cotter, T.G., Dose"dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli, Cell Proliferation, 24, (2), 1991, p203-214
Moriarty, M., Maher, M., Morton, G., Flavin, A., Mooney, E., Neilan, J., Nestor, P., Horgan, P.G., Kerin, M., Waldron, D., Gannon, F., Given, H., McCann, A.H., Dervan, P.A., Codd, M.B., Guillick, W.J., Carney, D.N., Horgan, P.G., O'Brien, D.P., Waldron, D.J., Mooney, E., McGuire, M., Given, H.F., Dolan, J., O'Hora, A., Droogan, O., Curran, B., Henry, K., Leader, M., Meehan, S., Magee, H., Carney, D., Dervan, P., Lawler, M., McCann, S.R., Humphries, P., Barrett, J., O'Sullivan, G., Collins, J.K., Williams, N., Daly, J., Herlyn, M., Corbally, N., Sweeney, E., Dervan, P., Carney, D.N., Sheppard, M.N., Hamid, Q., Corrin, B., Weedle, R.M., Cotter, T.G., Wilkinson, Y.A., McKenna, P.G., Hahnvajanawong, C., O'Sullivan, G., McCarthy, M., Collins, J.K., Atkinson, R.J., Pedlow, P., McQuaid, S., Johnson, P., Stuart, J., O'Meara, A., Russell, S.E.H., White, P.M., Atkinson, R.J., Hickey, G.I., Pomeroy, M., Prosser, E., Barker, F., Casey, M., Carroll, K., O'Kennedy, R., Duffy, G., Fennelly, J.J., Duffy, M.J., Reilly, D., Fennelly, J.J., O'Higgins, N., Rochfort, H., O'Neal, K.L., Hoper, M., Odling-Smee, G.W., Abram, W.P., McKenna, P.G., Mooney, E., Brougham, C., Horgan, P., Waldron, D., O'Brien, D., Kerin, M., Heyden, D.R., Given, H.F., Lanigan, D., McLean, P., Murphy, D., Donovan, M.G., Curran, B., Leader, M., Martin, A., Clynes, M., Graham, D., Curran, B., McQuaid, S., Dorman, T., Breathnach, F., Fitzgerald, R.J., Leader, M., O'Meara, A., Lennon, S.V., Martin, S.J., Cotter, T.G., Ryan, L., Kilfeather, S.A., O'Malley, K., Nolan, K.B., Croke, D.T., Helene, C., Browne, P.V., Lawler, M., McCann, S.R., Clarke, E., McCann, S.R., Glynn, J., Cotter, K., Shine, M., Cotter, T., Sweeney, E., Dervan, P., Carney, D.N., McKelvey, V.J., Stefani, L.A.J., McKenna, P.G., Ranjbar, S., Cromie, E., Eason, S., Hannigan, B.M., Corbett, A., O'Sullivan, G., Collins, J.K., O'Brien, F., O'Sullivan, G., Collins, J.K., Carney, D.N., Grogan, L., Leonard, N., Morton, G., Flavin, A., Moriarty, M., Foley-Nolan, D., McCann, A., Carney, D.N., Fennelly, J.J., Jones, M., Garrett, C., Pomeroy, M., Brennan, D.P., Powell, D., Irish association for cancer research - Proceedings of Annual Scientific Meeting, University College, Cork, 30th-31st March, 1990., Irish Journal of Medical Science, 160, (4), 1991, p116-126
Martin, S.J., Bonham, A.M., Cotter, T.G., The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells, Biochemical Society Transactions, 18, (4), 1990, p634-636
Martin, S.J., Bradley, J.G., Cotter, T.G., HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis, Clinical and Experimental Immunology, 79, (3), 1990, p448-453
Martin, S. J., Bradley, J. G. M. and T. G. Cotter , HL-60 cells induced to differentiate towards neutrophils subsequently undergo a programmed cell death (apoptosis), Clinical and Experimental Immunology, 79, 1990, p448 - 453
Martin, S. J., Lennon, S. V., Bonham, A. M. and T. G. Cotter , Induction of apoptosis (programmed cell death) in human leukaemic HL-60 cells by inhibiton of RNA or protein synthesis, The Journal of Immunology, 145, 1990, p1859 - 1867
Martin, S.J., Cotter, T.G., Specific loss of microtubules in HL-60 cells leads to programmed cell death (apoptosis), Biochemical Society Transactions, 18, (2), 1990, p299-301
Cotter, T. G., Lennon, S. V., Glynn, J. and S. J. Martin, Cell death via apoptosis and its relationship to growth development and differentiation of both tumoral and normal cells, AntiCancer Research, 10, 1990, p1153 - 1160
Martin, S. J. and T. G. Cotter , Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells, Cell and Tissue Kinetics, 23, 1990, p545 - 559
Martin, S.J., Bradley, J.G., Cotter, T.G., Identification and characterization of a low molecular mass cell surface antigen which is deposited extracellularly by differentiating U-937 cells, Biochemical Society Transactions, 17, (2), 1989, p418-419
Downing, C.P., Boland, F.M., Foley, J.B., Improved noise canceller performance by means of an adaptive arrangement , Proceedings of IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP , 3, 1989, pp2005-2008
Fahy, E., Martin, S. J. and Mulrooney, M, Interactions of roach and bream in an Irish reservoir, Archives of Hydrobiology, 114, 1988, p291 - 309
Martin, S. J. and Fahy, E, Food and growth of cyprinids in a Co. Dublin reservoir, Irish Naturalists Journal, 22, 1986, p107 - 110
Non-Peer-Reviewed Publications
Bouchier-Hayes L & Martin SJ, CARDINAL roles in apoptosis and NFkappaB activation., Vitamins and Hormones, 67, 2004, p133 - 147
Martin, S. J. , Caspase activation cascades in apoptosis., Chemtracts-Biochemistry and Molecular Biology, 16, 2003, p352 - 360
Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin]
Caspases: Structure, activation pathways and substrates in, X.-M. Yin and Z. Dong , In Essentials of Apoptosis-A guide for basic and Clinical Research, New Jersey,USA, Humana Press, 2003, pp3 - 12, [Murphy, B.M. and S.J Martin]
Caspase cascades in apoptosis in, editor(s)M. Los and H. Walczak , In Caspases-Their role in Cell Death and Cell Survival, New York, USA, Landes Bioscience/Kluwer Academic/Plenum Publishers, 2002, pp41 - 51, [S.J Martin]
Apoptosis and Cancer: an overview in, editor(s)S. J. Martin , In Apoptosis and Cancer , Austin, Texas, USA, S.J. Martin, 1997, pp1 - 8, [S.J. Martin]
Apoptosis: an introduction in, S. J. Martin , In Apoptosis and Cancer , Austin, Texas, USA, Landes Bioscience Publishers, 1997, pp9 - 24, [Martin, S. J]
Cell-free apoptosis in, editor(s)Martin, S. J., and D. R. Green , In Techniques in Apoptosis: A User's Guide , Portland Press, London, S.J Martin and D. R. Green, 1996, [S.J Martin]
Annexin V in, editor(s)Edited by T. G. Cotter and S. J. Martin , a specific probe for apoptotic cells. In Techniques in Apoptosis: A User's Guide , Portland Press, London, S. J Martin,C.P.M, Reutelingsperger and D. R. Green, 1996, [S. J Martin]
S. J Martin,Amarante-Mendes, G. P., and Green, D. R, Cytotoxic lymphocyte killing enters the ICE age, Adv. Exp. Med. Biol, 406, 1996, p29 - 37
Martin, S. J., and Green, D. R, HIV-induced apoptosis: a cytopathic effect of HIV or an important host-defense mechanism against viruses in general, Advances in Experimental Medicine and Biology , 374, 1995, p129 - 138
Apoptosis of human leukaemia cells: Induction, morphology, and molecular mechanisms in, editor(s)F. Cope and D. Tomei , Apoptosis II: the molecular basis of apoptosis in disease , Cold Spring Harbour, Cold Spring Harbour Laboratory Press, 1994, pp185 - 229, [Martin, S. J. and Cotter, T. G. ]
Assays of cellular activity in, editor(s)PJ Delves , Cellular Immunology LabFax , Oxford, UK, Bios Scientific Publishers, 1994, pp95 - 113, [McCulloch, J. and S. J. Martin ]
S.J. Martin. and T. G. Cotter , Specific loss of microtubules leads to programmed cell death , Biochemical Society Transactions , 18, 1990, p299 - 301
Lennon, S. V., Martin, S. J. and T. G. Cotter , Induction of apoptosis (programmed cell death) in tumor cell lines by widely diverging stimuli, Biochemical Society Transactions , 18, 1990, p343 - 345
S.J Martin,J.G Bradley, M. and T. G. Cotter , Identification and characterization of a low molecular mass cell surface differentiation antigen which is deposited extracellularly by differentiating U-937 cells. , Biochemical Society Transactions , 17, 1989, p418 - 419
Apoptosis as a mode of cell death in cultures of differentiating human leukemia cells in, editor(s)K. H. Chadwick, C. Seymour, and B. Barnhart , Transformation and radiation-induced cancer, Bristol, Adam Hilger, 1989, pp25 - 32, [Cotter, T. G. and Martin, S. J.]
Research Expertise
Description
The Martin laboratory is interested in all aspects of programmed cell death, especially the links between cell death, inflammation and cancer. Some key papers: Introduction of annexin V-labelling, the gold standard for measuring apoptosis (Martin et al., 1995 J. Exp. Med.), Unravelling the apoptosis-associated caspase activation cascade (Slee et al., 1999 J. Cell Biol.), Oncogenic Ras promotes autophagic cell death (Elgendy et al., 2011 Molecular Cell), Apoptotic cells can be pro-inflammatory (Cullen et al., 2013 Molecular Cell; Henry et al., 2017 Molecular Cell), Parkin activation can promote apoptosis (Hollville et al., 2014 Molecular Cell; Carroll et al., 2014 Cell Reports) Discovery of the mechanism of activation of the IL-36 cytokine family (Henry et al., 2016 Cell Reports; Clancy et al., 2018 Cell Reports); ER Stress promotes inflammation via TRAIL receptors (Sullivan et al., 2020 Developmental Cell); IL-37 is pro-inflammatory via IL-36 receptor engagement (Sullivan et al., 2022 Science Immunology). Necrotic cell death either instigates inflammation (in sterile injury contexts) or is a key amplifier of inflammation (during infection). In both scenarios, molecules released from dead cells (collectively called DAMPs, damage-associated molecular patterns) trigger inflammation. However, exactly what constitutes a DAMP has been the subject of much debate. We are currently exploring the idea that members of the extended IL-1 family constitute the key DAMPs and how IL-1 family cytokines become activated/inactivated. We are also actively exploring how cell stress (e.g. due to chemotherapy) triggers inflammation Molecular Control of Apoptosis (programmed cell death). Natural Killer Cell and CTL proteases (particularly granzyme B) and their mode of action. The role of Bcl-2 family proteins in chemoresistance in cancer. The role of caspases in inflammation. IL-1 family cytokines and inflammation. Cell Stress and Inflammation. Cell Senescence and Inflammation. Cancer chemotherapy. Regulation of entry to cell senescence by chemotherapy.Recognition
Representations
Scientific Consultant, Clontech Inc. Palo Alto, USA.
Appointed to the Board of the European working group on Apoptosis.
Appointed to Editorial Board, Cell Death & Differentiation.
Senior Editor, 'Cell Death & Differentiation', Nature Publishing Group
Scientific Advisory Board, Association for International Cancer Research, UK.
PhD examiner for The University of Dundee, University of Bristol, University of Leicester, Dublin Institute of Technology, NUI Maynooth.
Medical Research Council, UK Appointments & Tenure committees
External Assessor for full professor & Personal Chair appointments, Scripps Institute, La Jolla, USA; University of Dundee, UK; University of Melbourne, Australia.
Awards and Honours
Institute of Biology of Ireland Gold Medal
Human Frontier Science Program Organization Long-term Fellowship Award
Wellcome Trust International Prize Travelling Fellowship Award.
Wellcome Trust Senior Fellowship in Biomedical Science
Elected to Fellowship of Trinity College Dublin.
Science Foundation Ireland Fellow
Scientific Advisory Board, Association of International Cancer Research, UK
Short-listed for The Royal Irish Academy Boyle Medal
Elected to the Board of Directors, International Cell Death Society, New York
Elected to the Board of Directors of ECDO
The BA Charles Darwin Award Lecture
GlaxoSmithKline Award (Biochemical Society UK) 2005
Memberships
American Society for Biochemistry and Molecular Biology.
American Association for the Advancement of Science.
The Biochemical Society.