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Professor Kevin Devine
Fellow Emeritus, Genetics

Publications and Further Research Outputs

Peer-Reviewed Publications

Prunty, M.P. and Noone, D. and Devine, K.M., The distinct PhoPR mediated responses to phosphate limitation in Bacillus subtilis subspecies subtilis and spizizenii stem from differences in wall teichoic acid composition and metabolism, Molecular Microbiology, 109, (1), 2018, p23-40 Journal Article, 2018 DOI

Devine, K.M., Activation of the PhoPR-mediated response to phosphate limitation is regulated by wall teichoic acid metabolism in Bacillus subtilis, Frontiers in Microbiology, 9, (NOV), 2018 Journal Article, 2018 TARA - Full Text DOI

Salzberg L.I, Botella E, Hokamp K, Antelmann H, Maaà S, Becher D, Noone D, Devine K.M, Genome-wide analysis of phosphorylated PhoP binding to chromosomal DNA reveals several novel features of the PhoPR-mediated phosphate limitation response in Bacillus subtilis, Journal of Bacteriology, 197, (8), 2015, p1492 - 1506 Journal Article, 2015 DOI URL

McClean, D., McNally, L., Salzberg, L.L., Devine, K.M., Brown, S.P. & Donohue, I., Single gene locus changes perturb complex microbial communities as much as apex predator loss, Nature Communications, 6, 2015, 8235 Journal Article, 2015 DOI

Noone, D, Salzberg, LI, Botella, E, Basell, K, Becher, D, Antelmann, H, Devine, KM, A Highly Unstable Transcript Makes CwlO D, L-Endopeptidase Expression Responsive to Growth Conditions in Bacillus subtilis, JOURNAL OF BACTERIOLOGY, 196, (2), 2014, p237-247 Journal Article, 2014 DOI TARA - Full Text

Noone D, Salzberg L.I, Botella E, BÀsell K, Becher D, Antelmann H, Devine K.M, A highly unstable transcript makes CwlO D,L-endopeptidase expression responsive to growth conditions in bacillus subtilis, Journal of Bacteriology, 196, (2), 2014, p237 - 247 Journal Article, 2014 URL DOI

Botella, E., Devine, S.K., Hubner, S., (...), Noone, D., Devine, K.M., PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellular PAS domain during the PhoPR-mediated phosphate limitation response of Bacillus subtilis, Molecular Microbiology, 94, (6), 2014, p1242-1259 Journal Article, 2014 DOI

Salzberg, L.I., Powell, L., Hokamp, K., Botella, E., Noone, D., Devine, K.M. 2013, The WalRK (YycFG) and σI RsgI regulators cooperate to control CwlO and LytE expression in exponentially growing and stressed Bacillus subtilis cells, Molecular Microbiology, 87, (1), 2013, p180-195 Journal Article, 2013 DOI

Kevin M. Devine, Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research, Molecular Microbiology, 83, (1), 2012, p10-13 Journal Article, 2012 TARA - Full Text

Celikel, R., Veldore, V.H., Mathews, I., Devine, K.M., Varughese, K.I., ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain, Acta Crystallographica Section D: Biological Crystallography, 68, (7), 2012, p839-845 Journal Article, 2012 DOI

Noone D, Botella E, Butler C, Hansen A, Jende I, Devine KM, Signal perception by the secretion stress-responsive CssRS two-component system in Bacillus subtilis., Journal of bacteriology, 194, (7), 2012, p1800-1814 Journal Article, 2012 TARA - Full Text DOI

Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P, Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis., Science (New York, N.Y.), 335, (6072), 2012, p1103-1106 Journal Article, 2012 DOI

Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E, Hessling B, Kleijn RJ, Le Chat L, Lecointe F, Mäder U, Nicolas P, Piersma S, Rügheimer F, Becher D, Bessieres P, Bidnenko E, Denham EL, Dervyn E, Devine KM, Doherty G, Drulhe S, Felicori L, Fogg MJ, Goelzer A, Hansen A, Harwood CR, Hecker M, Hubner S, Hultschig C, Jarmer H, Klipp E, Leduc A, Lewis P, Molina F, Noirot P, Peres S, Pigeonneau N, Pohl S, Rasmussen S, Rinn B, Schaffer M, Schnidder J, Schwikowski B, Van Dijl JM, Veiga P, Walsh S, Wilkinson AJ, Stelling J, Aymerich S, Sauer U, Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism., Science (New York, N.Y.), 335, (6072), 2012, p1099-103 Journal Article, 2012 DOI

Botella, E., Noone, D., Salzberg, L.I., Hokamp, K., Devine, S.K., Fogg, M., Wilkinson, A.J., Devine, K.M., High-resolution temporal analysis of global promoter activity in Bacillus subtilis, Methods in Microbiology, 39, 2012, p1-26 Journal Article, 2012 DOI

Botella E, Hübner S, Hokamp K, Hansen A, Bisicchia P, Noone D, Powell L, Salzberg LI, Devine KM, Cell envelope gene expression in phosphate-limited Bacillus subtilis cells., Microbiology (Reading, England), 157, (Pt 9), 2011, p2470-2484 Journal Article, 2011 TARA - Full Text DOI

Bisicchia P, Bui NK, Aldridge C, Vollmer W, Devine KM, Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology., Molecular microbiology, 81, (1), 2011, p157-178 Journal Article, 2011 DOI

Foy N, Jester B, Conant GC, Devine KM, The T box regulatory element controlling expression of the class I lysyl-tRNA synthetase of Bacillus cereus strain 14579 is functional and can be partially induced by reduced charging of asparaginyl-tRNAAsn., BMC Microbiology, 10, (1), 2010, p196 Journal Article, 2010 URL TARA - Full Text DOI

Botella E, Fogg M, Jules M, Piersma S, Doherty G, Hansen A, Denham EL, Le Chat L, Veiga P, Bailey K, Lewis PJ, van Dijl JM, Aymerich S, Wilkinson AJ, Devine KM, pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis., Microbiology (Reading, England), 156, (Pt 6), 2010, p1600-8 Journal Article, 2010 DOI TARA - Full Text

Paola Bisicchia, Eric Botella and Kevin M. Devine, Suite of novel vectors for ectopic insertion of GFP, CFP and IYFP transcriptional fusions in single copy at the amyE andbglSloci in Bacillus subtilis, Plasmid, 64, (3), 2010, p143-149 Journal Article, 2010 TARA - Full Text

Bisicchia P, Lioliou E, Noone D, Salzberg LI, Botella E, Hübner S, Devine KM, Peptidoglycan metabolism is controlled by the WalRK (YycFG) and PhoPR two-component systems in phosphate-limited Bacillus subtilis cells., Molecular microbiology, 75, (4), 2010, p972-89 Journal Article, 2010

Jende I, Varughese KI, Devine KM, Amino acid identity at one position within the alpha1 helix of both the histidine kinase and the response regulator of the WalRK and PhoPR two-component systems plays a crucial role in the specificity of phosphotransfer., Microbiology (Reading, England), 156, (Pt 6), 2010, p1848-59 Journal Article, 2010 DOI TARA - Full Text

Dubrac S, Bisicchia P, Devine KM, Msadek T, A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway., Molecular microbiology, 70, (6), 2008, p1307-22 Journal Article, 2008

Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Söll D, From one amino acid to another: tRNA-dependent amino acid biosynthesis., Nucleic acids research, 36, (6), 2008, p1813-25 Journal Article, 2008

Westers L, Westers H, Zanen G, Antelmann H, Hecker M, Noone D, Devine KM, van Dijl JM, Quax WJ, Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome., Proteomics, 8, (13), 2008, p2704-13 Journal Article, 2008

Bisicchia P, Noone D, Lioliou E, Howell A, Quigley S, Jensen T, Jarmer H, Devine KM, The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis., Molecular microbiology, 65, (1), 2007, p180-200 Journal Article, 2007

Howell A, Dubrac S, Noone D, Varughese KI, Devine K, Interactions between the YycFG and PhoPR two-component systems in Bacillus subtilis: the PhoR kinase phosphorylates the non-cognate YycF response regulator upon phosphate limitation., Molecular microbiology, 59, (4), 2006, p1199-215 Journal Article, 2006

Howell, A., Dubrac, S., Noone, D. and Devine, K.M. , The essential YycFG TCS of B. subtilis interacts at two levels with the PhoPR TCS, one of which involves phosphorylation of the yycF response regulator by the PhoR sensor kinase., Molecular Microbiology, 2005 Journal Article, 2005

Hallin, P.F., Nielsen, N., Devine, K.M., Binnewies, T.T., Willenbrock, H. and Ussery, D. , Genome Update: base skews in 200+ bacterial chromosomes. , Microbiology, 151, (3), 2005, p633 - 637 Journal Article, 2005

Ataide,S.F., Jester, B.C., Devine, K.M. and Ibba, M. , Stationary phase expression and aminoacylation of a tRNA-like small RNA., EMBO Reports, 6, (8), 2005, p742 - 747 Journal Article, 2005

Howell A, Dubrac S, Andersen KK, Noone D, Fert J, Msadek T, Devine K , Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach, Molecular Microbiology, 49, (6), 2003, p1639 - 1655 Journal Article, 2003

Kobayashi, K., Ehrlich S.D., Albertini A., Amati G., Andersen K.K., Arnaud M., Asai K., Ashikaga S., Aymerich S., Bessieres P., Boland F., Brignell S. C., Bron S., Bunai K., Chapuis J., Christiansen L.C., Danchin A., Débarbouillé M., Dervyn E., Deuerling E., Devine K. M., Devine, S.K., Dreesen, O., Errington J., Fillinger S., Foster S.J., Fujita Y., Galizzi A., Gardan R., Eschevins C., Fukushima T., Haga K., Harwood C. R., Hecker M., Hosoya D., Hullo M.F., Kakeshita H., Karamata D., Kasahara Y., Kawamura F., Koga K., Koski, P., Kuwana R., Imamura D., Ishimaru M., Ishikawa S., Ishio I., Le Coq D, Mason A., Mauël C., Meima R., Mellado R.P., Moir A., Moriya S., Nagakawa E., Nanamiya H., Nakai S., Nygaard P., Ogura M., Ohanan T., O'Reilly, M., O'Rourke M., Pragai Z., Pooley H.M., Rapoport G., Rawlins, J.P., Rivas L.A., Rivolta C., Sadaie A., Sadaie Y., Sarvas M., Sato T., Saxild H.H., Scanlan E., Schumann W., Seegers J.F.M.L., Sekiguchi J., Sekowska A., Séror S., Simon M., Stragier P., Studer R., Takamatsu H., Tanaka T., Takeuchi M., Thomaides, H.B., Vagner V., van Dijl JM., Watabe K., Wipat A., Yamamoto H., Yamamoto M., Yamamoto Y., Yamane K., Yata K., Yoshida K., Yoshikawa H., Zuber U. and Ogasawara, N. , Essential Genes in Bacillus sutbilis. , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, (8), 2003, p4678 - 4683 Journal Article, 2003 URL

Jester, B. C., J. D. Levengood, H. Roy, M. Ibba and Kevin M. Devine., Non-orthologous displacement of lysyl-tRNA synthetase prevents infiltration of the genetic code by lysine analogues. , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, (24), 2003, p14351 - 14356 Journal Article, 2003 DOI TARA - Full Text

Westers, H., Dorenbos, R., van Dijl, J.M., Kabel, J., Flanagan, T., Devine, Kevin M., Jude, F., Séror, S.J., Beekman, A.C., Darmon, E., Eschevins, C., de Jong, A., Bron, S., Kuipers, O.P., Albertini, A. M., Antelmann, H., Hecker, M., Zamboni, N., Sauer, U., Bruand, C., Ehrlich, S.D., Alonso, J.C., Salas, M., and Quax, W.J. , Genome engineering reveals large dispensable regions in Bacillus subtilis., Molecular Biology and Evolution , 20, (12), 2003, p2076 - 2090 Journal Article, 2003

Antelmann, H., Darmon, E., Noone, D., Veening, J-M., Bron, S., Kuipers, O., Devine, K.M., Hecker, M. and van Dijl, J.M. , The extracellular proteome of Bacillus subtilis under secretion stress conditions., Molecular Microbiology , 49, (1), 2003, p143 - 156 Journal Article, 2003

Weller, G.R., Boris Kysela, Rajat Roy, Louise Tonkin, Elizabeth Scanlan, Susanne Krogh Devine, Jonathan P. Day, Adam Wilkinson, Kevin M. Devine, Richard P. Bowater, Penny Jeggo, Stephen P. Jackson and Aidan J. Doherty. , Identification of a DNA non- homologus end-joining complex in bacteria. , Science , 297, (5587), 2002, p1686 - 1689 Journal Article, 2002

Darmon, E., Noone, D., Masson, A., Bron, S., Kuipers, O., Devine, K.M. and van Dijl, M. , A novel class of heat shock and secretion stress responsive genes is controlled by the autoregulated CssR/S two-component system of Bacillus subtils., Journal of Bacteriology, 184, (20), 2002, p5661 - 5671 Journal Article, 2002

The Oxidative Stress Response in, editor(s)Schumann, W., Ehrlich, S.D. and Ogasawara, N. , Functional Analysis of Bacterial Genes: A Practical Manual, Wiley, 2001, pp215 - 227, [Scanlan, E., Hecker, M and Devine K.M. ] Book Chapter, 2001

Noone, D., A. Howell, R. Collery and K. M. Devine., YkdA and YvtA, HtrA-like serine proteases in Bacillus subtilis, engage in negative autoregulation and reciprocal cross-regulation of ykdA and yvtA gene expression , Journal of Bacteriology, 183, (2), 2001, p654 - 663 Journal Article, 2001 DOI TARA - Full Text

Screening for Increased Sensitivity or Resistance and Level of lacZ Reporter Gene Expression in Response to the Oxidizing Agents Hydrogen Peroxide and Methyl Viologen in, editor(s)Schumann, W., Ehrlich, S.D. and Ogasawara, N. , Functional Analysis of Bacterial Genes: A Practical Manual, Wiley, 2001, pp227 - 230, [Scanlan, E., O'Reilly, M., Andersen, K.K., Noone, D. and Devine, K.M.] Book Chapter, 2001

Akbar, S., Gaidenko, T.A., Kang, C.M., O'Reilly, M., Devine, K.M. and Price, C.W., New family of regulators in the environmental signaling pathway which activates the general stress transcription factor sigma(B) of Bacillus subtilis , Journal of Bacteriology, 183, (4), 2001, p1329 - 1338 Journal Article, 2001

Noone, D. Howell, A. and Devine, K.M., Expression of YkdA, a member of the HtrA family of serine proteases, is heat shock inducible and negatively autoregulated in Bacillus subtilis., Journal of Bacteriology, 182, (6), 2000, p1592 - 1599 Journal Article, 2000 URL

Krogh, S, Jorgensen, ST, Devine, KM, Lysis genes of the Bacillus subtilis defective prophage PBSX, JOURNAL OF BACTERIOLOGY, 180, (8), 1998, p2110-2117 Journal Article, 1998 TARA - Full Text

McLean, M.J., Wolfe, K.H., Devine, K.M., Base composition skews, replication orientation, and gene orientation in 12 prokaryote genomes, Journal of Molecular Evolution, 47, (6), 1998, p691 - 696 Journal Article, 1998 DOI

Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Codani JJ, Connerton IF, Cummings NJ, Daniel RA, Denizot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, KlaerrBlanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, OReilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portetelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Tognoni A, Tosato V, Uchiyama S, Vandenbol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler E, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A , The complete genome sequence of the Gram-positive bacterium Bacillus subtilis , NATURE, 390, (6657), 1997, p249 - 256 Journal Article, 1997

OReilly, M, Devine, KM, Expression of AbrB, a transition state regulator from Bacillus subtilis, is growth phase dependent in a manner resembling that of Fis, the nucleoid binding protein from Escherichia coli, JOURNAL OF BACTERIOLOGY, 179, (2), 1997, p522-529 Journal Article, 1997 TARA - Full Text

Krogh, S, OReilly, M, Nolan, N, Devine, KM, The phage-like element PBSX and part of the skin element, which are resident at different locations on the Bacillus subtilis chromosome, are highly homologous, MICROBIOLOGY-UK, 142, 1996, p2031-2040 Journal Article, 1996 TARA - Full Text

Devine, K.M.,Wolfe, K, Bacterial genomes: A TIGR in the tank, Trends in Genetics, 11, (11), 1995, p429-431 Journal Article, 1995 DOI

McDonnell GE, Wood H, Devine KM, McConnell DJ, Genetic control of bacterial suicide: regulation of the induction of PBSX in Bacillus subtilis., Journal of bacteriology, 176, (18), 1994, p5820-30 Journal Article, 1994 TARA - Full Text

OREILLY, M, DEVINE, KM, SEQUENCE AND ANALYSIS OF THE CITRULLINE BIOSYNTHETIC OPERON ARGC-F FROM BACILLUS-SUBTILIS, MICROBIOLOGY-UK, 140, 1994, p1023-1025 Journal Article, 1994 TARA - Full Text DOI

O'Reilly, M., Woodson, K., Dowds, B.C.A., Devine, K.M., The citrulline biosynthetic operon, argC-F, and a ribose transport operon, rbs, from Bacillus subtilis are negatively regulated by Spo0A, Molecular Microbiology, 11, (1), 1994, p87-98 Journal Article, 1994 DOI

WOODSON, K, DEVINE, KM, ANALYSIS OF A RIBOSE TRANSPORT OPERON FROM BACILLUS-SUBTILIS, MICROBIOLOGY-UK, 140, 1994, p1829-1838 Journal Article, 1994 TARA - Full Text

Seery, L., Devine, K.M., Analysis of features contributing to activity of the single-stranded origin of Bacillus plasmid pBAA1, Journal of Bacteriology, 175, (7), 1993, p1988-1994 Journal Article, 1993 TARA - Full Text

Seery, L.T., Nolan, N.C., Sharp, P.M., Devine, K.M., Comparative analysis of the pC194 group of rolling circle plasmids, Plasmid , 30, (3), 1993, p185-196 Journal Article, 1993 DOI

Sharp, P.M., Nolan, N.C., Ni Cholmain, N., Devine, K.M., DNA sequence variability at the rplX locus of Bacillus subtilis, Journal of General Microbiology , 138, (1), 1992, p39-45 Journal Article, 1992 TARA - Full Text DOI

Wood HE, Devine KM, McConnell DJ, Characterisation of a repressor gene (xre) and a temperature-sensitive allele from the Bacillus subtilis prophage, PBSX., Gene, 96, (1), 1990, p83-8 Journal Article, 1990

Wood HE, Dawson MT, Devine KM, McConnell DJ, Characterization of PBSX, a defective prophage of Bacillus subtilis., Journal of bacteriology, 172, (5), 1990, p2667-74 Journal Article, 1990 TARA - Full Text

Devine KM, Hogan ST, Higgins DG, McConnell DJ, Replication and segregational stability of Bacillus plasmid pBAA1., Journal of bacteriology, 171, (2), 1989, p1166-72 Journal Article, 1989 TARA - Full Text

SHARP, PM, DEVINE, KM, CODON USAGE AND GENE-EXPRESSION LEVEL IN DICTYOSTELIUM-DISCOIDEUM - HIGHLY EXPRESSED GENES DO PREFER OPTIMAL CODONS, NUCLEIC ACIDS RESEARCH, 17, (13), 1989, p5029-5039 Journal Article, 1989 TARA - Full Text

Dowds BC, Murphy P, McConnell DJ, Devine KM, Relationship among oxidative stress, growth cycle, and sporulation in Bacillus subtilis., Journal of bacteriology, 169, (12), 1987, p5771-5 Journal Article, 1987 TARA - Full Text

Murphy P, Dowds BC, McConnell DJ, Devine KM, Oxidative stress and growth temperature in Bacillus subtilis., Journal of bacteriology, 169, (12), 1987, p5766-70 Journal Article, 1987 TARA - Full Text

McConnell DJ, Cantwell BA, Devine KM, Forage AJ, Laoide BM, O'Kane C, Ollington JF, Sharp PM, Genetic engineering of extracellular enzyme systems of Bacilli., Annals of the New York Academy of Sciences, 469, 1986, p1-17 Journal Article, 1986

Recognition

Representations

Editor of BMC Microbiology 2005 -

Associate Editor of Microbiology 2000 -